<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAX6</accession>
    <name>A0A132PAX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_35980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000061">
        <property type="protein sequence ID" value="KWX19417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067860049.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19417">
        <property type="protein sequence ID" value="KWX19417"/>
        <property type="gene ID" value="AFM11_35980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6573"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="451" mass="49105" checksum="8A011C1DB2945156" modified="2016-06-08" version="1">MTTGKDVDSSLVEVDSTVEMAEALRASGAVDDLLAQIDSGEVALTGEGGLLPGLIKLALERGLAAELTDHLGYEKGDPIGRALPNARNGSSPKTVQTEAGPVPLDVPRDRDGSFTPTLVPKGQRRIGGLDDMIISLYAGGMTLRDIQFHLASTIGTEVSHETISKIVDEISDEVLAWQRRPLEPLYPVIYLDAMIVKVKDGGHTRNKAAHIAVGVDMDGIKHVLGIWVQPNEGASFWASVCSDLANRGVKDVLIVCCDGLTGFPEAIAATWSAAAVQTCVVHLIRNALRFVSYGDRKAVAAALKPVYTAPSVDAARAELDLFAASELGKNNPTVTKAFERAWEQFVPFLAFPPELRRVIYTTNSIESLNYQMRKVIKNRGQFPNDASVVKLLWLAICNIEDKRAAERAKERGQKLCRTAPGRLVEGQVVTNWKKALEQLTLVYPDRIERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBB3</accession>
    <name>A0A132PBB3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34740</name>
        <name evidence="4" type="ORF">AWC31_10885</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859455.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10885"/>
    <dbReference type="EnsemblBacteria" id="KWX19619">
        <property type="protein sequence ID" value="KWX19619"/>
        <property type="gene ID" value="AFM11_34740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08984">
        <property type="protein sequence ID" value="ORX08984"/>
        <property type="gene ID" value="AWC31_10885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5295"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="117"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX08984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="456" mass="47907" checksum="502438A21A3BFC6F" modified="2016-06-08" version="1">MTAGTSRTGKPLAAAAIAQLESDGVATLIGTVVNPAGLTHAKTVPLRRMGIFADPGLGASPVFHAFTIDQTGIVFGDAISVVGDQRIRIDLGALRILGDGLAWAPGAFYNQDGTPDPYCSRGVLQRVADRLDAAGLTALVGHELEFVLVGEDGSRLPSVSWAQYGLAGLLEFEGFVRDVMNAATSSGVTIEQFHPEYGANQFEISLSPQQPVAAADQLVLMRIIVGRVARRYGMRVSLSPVPFADSVGSGSHQHFSLGRGDVPVFSGGSAARGMTPEGESALAGLLAGLPAAQGVLCGSVVSGLRIQPGHWAGAHNCWGTENREAAVRFLIGGPSNPYGANVEVKVIDPSANPYLATATILGLAHHGIEKNLPLPSEVSVDPSSLSDDERTEQNVALLPSRQIDALAALDESELIRGILGNQVVDAVLAVRRYEHEKFGDLDPESLADRFRMAWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBM8</accession>
    <name>A0A132PBM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859210.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19726">
        <property type="protein sequence ID" value="KWX19726"/>
        <property type="gene ID" value="AFM11_34350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5215"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="74" mass="7712" checksum="06FE79DD043CC542" modified="2016-06-08" version="1">MRAPDEPQFNVCPNASRPGLVHFSIGSGRDLFAITPELAEHLADELLAAAGAARRASGSEGEIARAAAEVARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBT3</accession>
    <name>A0A132PBT3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34125</name>
        <name evidence="3" type="ORF">AWC31_02575</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859083.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02575"/>
    <dbReference type="EnsemblBacteria" id="KWX19789">
        <property type="protein sequence ID" value="KWX19789"/>
        <property type="gene ID" value="AFM11_34125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11044">
        <property type="protein sequence ID" value="ORX11044"/>
        <property type="gene ID" value="AWC31_02575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5162"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="238" mass="25084" checksum="2A547DDDD68DE143" modified="2016-06-08" version="1">MQIAIVLYPSFTALDFIGPYEVLRALPDAEVRFVWHEPGPITADSGVLLVGATHSFDETPAPDVVLVPGGPGTVTTARDEKVLDWLRRVHPGATWTASVCSGSVVLAAAGLLDGKRATSHWSTLSALKAFGVTPVGDQRIVHEGDVITAAGVSAGIDLGMWLAGQIGGEAKAKAIQLMIEYDPQPPFDSGHMSKASATTKAAATALLGRDMIKPELLKDSVLLAWDRAIAKVRGRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC33</accession>
    <name>A0A132PC33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_34010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02460"/>
    <dbReference type="EnsemblBacteria" id="KWX19797">
        <property type="protein sequence ID" value="KWX19797"/>
        <property type="gene ID" value="AFM11_34010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5139"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="367" mass="36875" checksum="A1C9C1444D3FD39B" modified="2016-06-08" version="1">MRAAVFDGDGSITVETVDLAAPGPGEVRVKVAAAGVCHSDLHVTTRAWDVPAPVVLGHEGSGVVTAVGAGVDDLEPGDHVVLSWVPGCGECRACKAGRPAQCSLVASVVAAGGTLYDGTTRLSNERGPIHHYLGVSSYAEQVVVPRSGAIKVRKDAPLEDIAIVGCAIATGVGAVRNTAGVQPGSTVAVIGCGGVGLACVQGARLAGAERIVAVDVVAEKLDLARKLGATDVVDASATDDVVAALRDVVADGFDYVFDAIGKIVTTEQAIAALGLGGAAVIVGLPPAGERATFDPLALAEGDQRILGSNYGSAVPERDIPALVDEVMAGNLDLASMISGRRPLDEAAAALDDLAAGHALRQLLIPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCJ2</accession>
    <name>A0A132PCJ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_32370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858055.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19495"/>
    <dbReference type="EnsemblBacteria" id="KWX20061">
        <property type="protein sequence ID" value="KWX20061"/>
        <property type="gene ID" value="AFM11_32370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4802"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="118"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="225"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="362" mass="39771" checksum="E1273721B50C26D3" modified="2016-06-08" version="1">MDFRDSPEEAAFRDRLRAWLADNAASFKASGDDYWARQGEWHQALYAAGFFGTSWPKEFGGQELPPVYDVIVDEELARAGAPPRPSLGYLVVGLGHHGSKELQQRFLPGMINGTERWCQGFSEPGAGSDLASLTTTATRDGDNYIINGHKIWTSYSDVADWCLVLARTDRDVPRHKGISAFIVSMHQDSIEQRPLQMINGVTTEFGQVAFDGAVVPASQMVGEPGDGWRLAMTVVSHEREPSTLGYSARYGKLVREMASRVDGRAPEELAWAAVQAEMLRLHVRRRLSEQLDGIKHGPQGSLDKLLMTWVEQSVGHAALAVTGTKDPELLSAYLYSRAQSVMGGTSQIQKNIIASRILGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCJ6</accession>
    <name>A0A132PCJ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858447.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32335"/>
    <dbReference type="EnsemblBacteria" id="KWX20036">
        <property type="protein sequence ID" value="KWX20036"/>
        <property type="gene ID" value="AFM11_32890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4907"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="330" mass="34974" checksum="2A219C3BEB6CEE36" modified="2016-06-08" version="1">MREVAAAASVSVGTVSNVLNAPDKVAPATVARVQAAIDRLGFVRNDAARQLKAGRSRSVGLVVLDIGNPFFTDIARAAERRAGEHDLTVLLGTSDDDTDRERAYIDAFDEQRVFGLLVSPVGEDLQRLTALHERGTPVVLVDRDGSGTPFDSVAVDDVAGARLAVEHLCATGRRRIAFVGGPGTLRQIRDRRRGAAAAIAEIPGAELEIIDTTAPSVQAGSAVGEQLRQRAPRDRPDGVFCANDLLAIGVLQALSLIGGLRVPDDMALVGYDDIDFARSAVVPLTSVRQPTRAIGSTAVDLLIAASEDSVRRRPKHVVFQPELIVRGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCR5</accession>
    <name>A0A132PCR5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858191.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19800"/>
    <dbReference type="EnsemblBacteria" id="KWX20106">
        <property type="protein sequence ID" value="KWX20106"/>
        <property type="gene ID" value="AFM11_32665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4861"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="278"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="362"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="535" mass="58054" checksum="1543A874225CB10C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCV2</accession>
    <name>A0A132PCV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20146">
        <property type="protein sequence ID" value="KWX20146"/>
        <property type="gene ID" value="AFM11_31880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4702"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="129"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="292" mass="31835" checksum="080EFC04C2A42214" modified="2016-06-08" version="1">MTTAPLDDVTETVRGKYDKLTNSQKRIAEMIIEDPEFVAFATVDKLASRLDVAASTVVRFAYKLGLDGYQDLQERIRRQIREQYRAVGEEGATPTSHLAGTPFQASLDNDFSHLQRTARALDREALEKAVTALAEAEHVYITGDLTSYCLAYFTAIAVGRARDRVRLVRADAEGATALLEMGPDDVLLAFTFPPYSRNVLRVVDWAVRRRTLTIGVTDAAISPVGQRVSIVLSVMAGGIGPQNTLVPGMAVANALVNGLFERNEDVSVDRYKAVGSLAADWDLFVLGPDNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD08</accession>
    <name>A0A132PD08_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_33710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08045"/>
    <dbReference type="EnsemblBacteria" id="KWX19852">
        <property type="protein sequence ID" value="KWX19852"/>
        <property type="gene ID" value="AFM11_33710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5078"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="510" mass="54941" checksum="1C1C0C6B91AA5C09" modified="2016-06-08" version="1">MVRIASVAALGGLLFGYDSAVINGAVAALQDEFAINDVTLGFAVASALLGAAVGALTAGRLADKIGRRSVMKLAAVLFFVSAIGTAFATHIWLVVIFRIVGGLGVGVASVIAPTYIAETAPPRIRGRLGSLQQLAIVTGIFLSLSIDYLLAHLAGGSREELWLGMAAWRWMFLVMAVPAVVYGVLAYTIPESPRYLVAQFRIPEARRVLTMLLGEKNLEITIHRIEDSLKSEKPPSWQDLLKPRLPGMSASSFTAWVRRYLWWLMLLFIVLAVVAVFFGWWLLALVFGALGVGVAVIGGLYGIVWVGLGLSIFQQFVGINVIFYYSNVLWEAVGFDESQAFTITVITSVTNIVTTLIAIALIDKIGRKPLLLIGSTGMAVTLGTMAVIFGTAPQVDGQPQLSGAAGPIALIAANLFVVAFGMSWGPVVWVLLGEMFPNRIRAAALGLAAAGQWVANWLITVSFPELRNVLGVAYGFYALCAVLSFIFVWRWVEETKGKHLEDMHAEALRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD23</accession>
    <name>A0A132PD23_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS glucose transporter subunit IIBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_31360</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857465.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25515"/>
    <dbReference type="EnsemblBacteria" id="KWX20238">
        <property type="protein sequence ID" value="KWX20238"/>
        <property type="gene ID" value="AFM11_31360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4178"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="18"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="446"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX20238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="521" mass="55246" checksum="91E46C0769B65F0D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDN2</accession>
    <name>A0A132PDN2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856754.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20438">
        <property type="protein sequence ID" value="KWX20438"/>
        <property type="gene ID" value="AFM11_30085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3911"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="945"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1743" mass="193634" checksum="5CEAE7E7CABC6644" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDT8</accession>
    <name>A0A132PDT8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32015"/>
    <dbReference type="EnsemblBacteria" id="KWX20132">
        <property type="protein sequence ID" value="KWX20132"/>
        <property type="gene ID" value="AFM11_31790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4685"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026820">
        <property type="entry name" value="VioB/RebD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12902">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like" evidence="1">
        <location>
            <begin position="39"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="443" mass="48775" checksum="E72FD27148D69197" modified="2016-06-08" version="1">MTYAVARPGRAGAITTADEVTIPDLGNWPTARDKMRILLETAAEIEHALLVQYLYAAFSLKARGEVSDAAQKAALKMWKDLLVETATDEMGHLMTVQNLLLAVGLPPNLEREDFPPRKDLYPFTLHLEPLTQRSLAKYVAAEAPRDADIDDIVALAADAAGTAVNRVGALYGLLGVVFSTEQEVLDGGSISQDWDDTLRLYAGAAYEQDPDRASWHLTDDVIDRNTLARQGDGTDWLNNGVPIHRIADRTGARSAILDIAVQGEGPSEGGIESHFDRYHNMFVGQNGVKKFPPDDFVATRPLPVDPVASSFTEPRTRAWAELADLRYELMLGFIEHYLLTSDVDERRKASSWALEEMFQLAAMNEALVKLPGPGVVAFGLPHTLHLPADPAERWALHRARTEKSLVHVAQMRLEPLDTAHPILASLSDEDTRRLADMPVPLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE75</accession>
    <name>A0A132PE75_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856671.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25350"/>
    <dbReference type="EnsemblBacteria" id="KWX20630">
        <property type="protein sequence ID" value="KWX20630"/>
        <property type="gene ID" value="AFM11_30010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3894"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="56"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="408" mass="44939" checksum="3958E81C1F3E4457" modified="2016-06-08" version="1">MTTTEAPVKFEYDRIPYLVAYQNNSSVRDVYGGVAELVVLESYLLKPKARPSDTVLVFMHPIGGGAYLPMINALARAGHHVIYCNSRFRGTDSALLMEKVVEDLGECIKDAKNCLGYEKVVLAGWSGGGSLSVFYQQQAQHPTVTASPSGDGPDLTKLGLIPADGIMLLAAHISRHGTMTEWMDASILDENDPTKRDPELDLYNPDNPNQPPYTPEFLERYRRAQIARNRRITKWVKDKLAELKAAGRPDDEFAFVVHGTMADPRWLDPTVDPNERTPGTCYLGDPQVVNMSPVGLARFCTLRSWLSQWSYDDANGDAVKAGPDIAVPALVIGNLADDACTPSHTRRLYEAIGHPDKEMHEIPGANHYYSGPDQRDKLRQAVEVCTDWLHRHGFSSAGGTATTGDSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE91</accession>
    <name>A0A132PE91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856711.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25120"/>
    <dbReference type="EnsemblBacteria" id="KWX20643">
        <property type="protein sequence ID" value="KWX20643"/>
        <property type="gene ID" value="AFM11_29780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3848"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="21059" checksum="052496821CF2A69A" modified="2016-06-08" version="1">MAPVRGRPRSFDRDAALDKAIRLFWERGFEATSTRDLSSALGVGIPSIYAAFGDKQQLFTEAVAVYDTRYGGFIEAALTEEPTARRAVARILTEAPGRYTRRGLPSGCLVVSGDDGTADEAVKACLRRIRRQKTDMLADKIRTDIAAGDLPDDTDARALAQYVMTTLSGIAQAASDGTSRAMLDRVAAIALRAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEF1</accession>
    <name>A0A132PEF1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040625.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20718">
        <property type="protein sequence ID" value="KWX20718"/>
        <property type="gene ID" value="AFM11_29340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3757"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="60" mass="7288" checksum="A7009F42A26A92E2" modified="2016-06-08" version="1">MRPGASLVGYHRERGYRHDELLDLGYIKYTLVNESTQHPLFLWRRRTQRPIIRDGYRQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF53</accession>
    <name>A0A132PF53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_28270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855926.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10820"/>
    <dbReference type="EnsemblBacteria" id="KWX20965">
        <property type="protein sequence ID" value="KWX20965"/>
        <property type="gene ID" value="AFM11_28270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3528"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="213" mass="23711" checksum="54964D46675DAE94" modified="2016-06-08" version="1">MVDTVKRPYRSELRAAQAAETRRAVVAAAARLFVEHGYRATTIDAVAAAAGVSRKTVFSSGGGKVDLLKLAVDWAVAGDDQPVGLADRDPITRLFDHDDPVRLLRGWARLLADIDVRTARLFRAVEIAADEDPDAARLLAELHRQRLDGARRVVKHLRERNALTAHRRPGDAVDVAWLATDPVLFDRLVRERGWTVRRFADWLGETLVRELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFH8</accession>
    <name>A0A132PFH8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27195</name>
        <name evidence="4" type="ORF">AWC31_07125</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855336.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07125"/>
    <dbReference type="EnsemblBacteria" id="KWX21063">
        <property type="protein sequence ID" value="KWX21063"/>
        <property type="gene ID" value="AFM11_27195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09961">
        <property type="protein sequence ID" value="ORX09961"/>
        <property type="gene ID" value="AWC31_07125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3314"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="250" mass="26982" checksum="138903B0611D3FE4" modified="2016-06-08" version="1">MAKSRTAAETKAAKAEAKAARKAASKQRRSQLWQAFQMQRKEDKRLLPYMIGAFVLIVAIAVVAGVLIGGFTMYTLIPLGVVLGALVAFIIFGRRAQKSVYRKAEGQTGAAAWALDNLRGKWRVTPGVAATGHFDAVHRVIGRPGVIFVAEGSPARVKPLLAQEKKRTARLVGDTPIYDIVVGNGEGEVPLSKLERHLTKLPANITAKQMDSLESRLAALGTKVGPAAMPKGPMPAQAKMRGVQRTVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFM7</accession>
    <name>A0A132PFM7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">murD</name>
        <name evidence="17" type="ORF">AFM11_27480</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855491.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07415"/>
    <dbReference type="EnsemblBacteria" id="KWX21113">
        <property type="protein sequence ID" value="KWX21113"/>
        <property type="gene ID" value="AFM11_27480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3370"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="122"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="317"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KWX21113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="491" mass="49699" checksum="B09684F9834AEA1C" modified="2016-06-08" version="1">MSESDLAPLTTGAPVLVTGAGITGRAVLAALAPLGVAATLTDDSPTALTALAQQGVAVMDPAGAVERISDFVLVVTSPGFAPSAPVPAAAAAAGVPIWGDVELAWRLDAAGRFGTPRRWLVVTGTNGKTTTTSMLHDMLVADGRRSLLCGNIGEPVLAVLDRPAELLAVELSSFQLHWAPSLRPEAGVVLNVAEDHLDWHGSMDAYARDKARVLDGRVAVAGLDDPVAAGLLATAAAPVHVGFRLGEPAAGELGVRADKLVDRAFGDGVELADTGSIGVAGPVGVLNALAAAALARAVGVAPQSIAAALASFQVGAHRAEVVGMGDGVRYVDDSKATNPHAAQASITAYERVVWIAGGLLKGASVDELVRQVANRLAGAVLIGRDRYLVAEALSRHAPDVPVVELVTGEDSGVLETNESTESNDVHVTRVIEVGGRSVSDAVMAAAVGAARELASPGDTVLLAPAGASFDQFSGYGQRGDAFAAAVRAAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFV3</accession>
    <name>A0A132PFV3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855015.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22720"/>
    <dbReference type="EnsemblBacteria" id="KWX21226">
        <property type="protein sequence ID" value="KWX21226"/>
        <property type="gene ID" value="AFM11_26615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3194"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="281" mass="30130" checksum="F1C8EAF449AB8130" modified="2016-06-08" version="1">MNVGDAGAAGQATPGPGHPFVVAHRGASADRPEHTLAAYDLALREGADGVECDVRLTRDGHLVCVHDRRIDRTSTGSGLVSEMTLAELRKLDYGSWHASSRVEGGNGETGLLTLDDLVALVLDWNRPVKLFIETKHPVRYGALVENKVLALLHRYGIAAPPSADLSRAVVMSFSAAAVWRIRRAAPMLPTVLLGETSRYLGGSAATTVGATAVGPSIATLREHPELVDRAAAQGRALYCWTVDHYEDVRFCRDIGVAWVATNHPGRTKDWLQNGLTGAGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFV4</accession>
    <name>A0A132PFV4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855049.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22655"/>
    <dbReference type="EnsemblBacteria" id="KWX21239">
        <property type="protein sequence ID" value="KWX21239"/>
        <property type="gene ID" value="AFM11_26680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3207"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="467"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="518" mass="58548" checksum="A8A614F7C38BE696" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG04</accession>
    <name>A0A132PG04_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22600"/>
    <dbReference type="EnsemblBacteria" id="KWX21278">
        <property type="protein sequence ID" value="KWX21278"/>
        <property type="gene ID" value="AFM11_26735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3218"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="677" mass="74358" checksum="5D70C341F602246A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG78</accession>
    <name>A0A132PG78_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854512.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36145"/>
    <dbReference type="EnsemblBacteria" id="KWX21331">
        <property type="protein sequence ID" value="KWX21331"/>
        <property type="gene ID" value="AFM11_25750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3014"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="320" mass="34008" checksum="40CEEAF91A5F5F35" modified="2016-06-08" version="1">MRAVLIVNPNATSTTPAGRDLLAHALESRVTLTVAHTDHRGHAIEIARDAARDGVDVLIVHGGDGTVNEVVNGVLPTCGTRPDAASAPAVAVVPGGSANVFARALGISPDPIEATNQLVDLLSDYRKGRPWRRIGLMDCGERWGVFTAGMGVDGDVVAAVEAQRAKGRKVTAGRYIRVAVRQFLASARKEPELTLHLPGIEPITGVHFAFVSNSSPWTYANTRPVWTNPGTTFETGLGVFATTSMNLWANLRLVRQMVAKNPRITGKHLIRNDDVSTVTVTSDTPVSCQIDGDYAGLRESVTFTAVPDALCVVAPPAKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGJ7</accession>
    <name>A0A132PGJ7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Muconolactone Delta-isomerase</fullName>
            <shortName evidence="7">MIase</shortName>
            <ecNumber evidence="5 7">5.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_25785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate</text>
            <dbReference type="Rhea" id="RHEA:12348"/>
            <dbReference type="ChEBI" id="CHEBI:58425"/>
            <dbReference type="ChEBI" id="CHEBI:58736"/>
            <dbReference type="EC" id="5.3.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Aromatic compound metabolism; beta-ketoadipate pathway; 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the muconolactone Delta-isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.4" evidence="5 7"/>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854524.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36110"/>
    <dbReference type="EnsemblBacteria" id="KWX21337">
        <property type="protein sequence ID" value="KWX21337"/>
        <property type="gene ID" value="AFM11_25785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3021"/>
    <dbReference type="UniPathway" id="UPA00157">
        <property type="reaction ID" value="UER00260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016159">
        <property type="term" value="F:muconolactone delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042952">
        <property type="term" value="P:beta-ketoadipate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026029">
        <property type="entry name" value="MLI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003464">
        <property type="entry name" value="Muconolactone_d_Isoase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02426">
        <property type="entry name" value="MIase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001486">
        <property type="entry name" value="CatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03221">
        <property type="entry name" value="muco_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="93" mass="10906" checksum="9D9A502F97A0E352" modified="2016-06-08" version="1">MLFHVRMDVHLPPDMDPDTRTHLVAREKAYSQQLQRSGKWPHIWRIVGEYSNFSIFDVESNDELHNLISGLPLFPYMDIHVTPLARHPSDVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGT4</accession>
    <name>A0A132PGT4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854274.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27675"/>
    <dbReference type="EnsemblBacteria" id="KWX21536">
        <property type="protein sequence ID" value="KWX21536"/>
        <property type="gene ID" value="AFM11_25355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2433"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="168" mass="18136" checksum="E146B8BE9127186D" modified="2016-06-08" version="1">MQATELSEHAAGVAISVIVNGRLVQRTVPPRLMLADFLRDELGLTGTHLGCEHGVCGACSVFVDGRSMRTCLMLAVQVDGLRVTTVEGLDEFEETRRLRQAFSERGGLQCGFCTPGFLVTAVELLRDPNTDKPLTEDSVREALSGNICRCTGYQGIMQAVLDAADCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGZ3</accession>
    <name>A0A132PGZ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854115.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27270"/>
    <dbReference type="EnsemblBacteria" id="KWX21477">
        <property type="protein sequence ID" value="KWX21477"/>
        <property type="gene ID" value="AFM11_25015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2364"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="80" mass="8414" checksum="A4C7A71C8FA12BB4" modified="2016-06-08" version="1">MVQAYVLIQTEVGRAEVVAKQLAALPGVISAEYVTGPYDVVLRISAETLTALQSDVMPSVQQVTGITRTLTCPIANGAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGZ5</accession>
    <name>A0A132PGZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853595.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24015"/>
    <dbReference type="EnsemblBacteria" id="KWX21619">
        <property type="protein sequence ID" value="KWX21619"/>
        <property type="gene ID" value="AFM11_24115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2182"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="253"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="508" mass="54638" checksum="5ADB18FA8121640E" modified="2016-06-08" version="1">MRSPLVIAVDCSTTAAKAIIVDAKGDLVGTGAQALETRTPAPHWFEQEAPDWWTATDEAVRQALSEIDDRGAVAAICVTHQRETFVCLDVDEKPIRPAILWMDGRADAETRRYGTQRVELLSGKPADITPGLYKLLWLRDHEPDTMARCHRIADVHTYLTHAMTGQWVSSSASVDPLALIDQATGDYSGELLELAGLNRGQFPDLVPTGTSLGPLRPEIAESWGLNGDVVVVAGTGDGQAAGLGLGVTDPGVAYLVLGTAVVIGAEMTSYLPSRAYRSMISAMPGQTTAETFSSSGTYLPTWFRTEFGDPDLGGAPDPRLERDAAALPVGSEGLLTLPYWNGAQTPHWDSQASGITIGWRGCHTKAHMYRSLLEGIAFELRMQLDGLEEARGERVEVLRAMGGGARSVLWTQILADVFGRPLEVCASGEVSALGAAAVALTAIGEFTSIPEAAAAVARTDAVIEPRTDAAGRYAELRALYQRIFTETRDMLHTLHDLGQHHETRGDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHL2</accession>
    <name>A0A132PHL2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_23555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853245.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28280"/>
    <dbReference type="EnsemblBacteria" id="KWX21825">
        <property type="protein sequence ID" value="KWX21825"/>
        <property type="gene ID" value="AFM11_23555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2066"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="430" mass="45947" checksum="4F2EB8DB5BC3E5EF" modified="2016-06-08" version="1">MTVIDDGSKVGTVRPAKVAFASFVGTAIEWYDFFIFGTAAALVFGVAFFPTLSPLSGTLAAFATFGVAFVSRPAGAIVFGHFGDRIGRKKMLVFSLVLMGSATVMIGLIPTYDQIGLAAPILLVIARLLQGFAVGGEWGGAVLMAVEHAPARRRAFYGSFPQAGVPAGLVLATLAFLIVERLPDEDLMAWGWRVPFLASSALLLVGMYVRLKVTESPEFERVRRSEKIVQRPIVSVLRFQWRPLAVGVFTQAASLVPFYLVTVFVLSYGPKELGLSREKILLSLLAACVLDIVTVPYASIVADRVGPRKMLIYGSVYMSAIGYPFFWLLQTGNGWAVLLAMILIVTIGHAVTYSAVAAYVAGLFPADVRYTGASVAYQMGGVVFSAPAPFIAVTLASSIPGYWALAAYLATACAATVLVLTFSKTAKVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHN1</accession>
    <name>A0A132PHN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_23485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853210.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28210"/>
    <dbReference type="EnsemblBacteria" id="KWX21813">
        <property type="protein sequence ID" value="KWX21813"/>
        <property type="gene ID" value="AFM11_23485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2052"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="27758" checksum="AAFC62EEB43A1ED6" modified="2016-06-08" version="1">MALETRDLVVQFPGKQEPTLKSISMTIPDGSFAVLVGASGSGKSTLLHCLAGLITPTSGIVTDNGEPVTEPNPRRGVAFQRDVLFPWMSVADNIDFALAARKVRKPERHDRIHELLDLVGLHAEVARQRPTELSGGMRQRVSIARVLAGEPTVMLMDEPFAALDALTRLRMQDLLIDLWTRLNRTIVFVTHDIDEAIRLADSVSVLRDGQIVDHIANPLSRPRPADTLADQAGYSDIRKTLHHQLGIDHAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHN2</accession>
    <name>A0A132PHN2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853307.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28385"/>
    <dbReference type="EnsemblBacteria" id="KWX21845">
        <property type="protein sequence ID" value="KWX21845"/>
        <property type="gene ID" value="AFM11_23665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2089"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="26840" checksum="B9F923EF17FB870F" modified="2016-06-08" version="1">MSRPVALITGPTSGLGAGFARRYALEGYDLVLVARDAARLEQLAGELQHEAGATVEVIPADLAVAADRAKVADRLRAGVQVLVNNAGFGTSGEFWTADFAQLQAQLDVNVTAVMELTHAALPSMIDARSGSVINVASVAGLLPGRGSTYSASKAWVIAFSEGLANGLHSTGVGVHALCPGFVHTEFHARAGIDMAGTPSFLWLEVDDVVRDCLAGVAAGKVVIVPGLQYKALTTGGRMVPRNLVRAITKVVGKGRERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHR4</accession>
    <name>A0A132PHR4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_22250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852663.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08960"/>
    <dbReference type="EnsemblBacteria" id="KWX21899">
        <property type="protein sequence ID" value="KWX21899"/>
        <property type="gene ID" value="AFM11_22250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1800"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012700">
        <property type="entry name" value="CP_lyase_PhnK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037116">
        <property type="entry name" value="CP_lyase_PhnK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="45"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="280" mass="29722" checksum="26BEAA8FCB9C19EF" modified="2016-06-08" version="1">MTATAIAEWDSERALVPPAPVLSVRGLSHRFGPGCDRCVDSTGEAAGTNRCSACGSVIAVHDASFDAGPDEVLGIVGESGSGKTTLLRCLHLDLVPEHGSILVGEHPIERSAVLMVHQNALAAGLYPRLAAESNVAERLLGSGARQFADIHARVAELLGELGLRSERHTDALMTFSGGMQQRVQLARALVDPPQVLLLDEPTTGLDPSVQADLLEVVGRVTENLSSATIVVSHDLAAVRILASRIVVLHHGRIVEHGIAEQVLEDPRHPYTQLLVSSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHU4</accession>
    <name>A0A132PHU4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852726.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08775"/>
    <dbReference type="EnsemblBacteria" id="KWX21929">
        <property type="protein sequence ID" value="KWX21929"/>
        <property type="gene ID" value="AFM11_22435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1837"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="25835" checksum="FF86459EA5D582EF" modified="2016-06-08" version="1">MAAAAKLHRHVGRRRAARFLAEGPNLVEAALRRGLVSEVFATESALDRFGAMLDGAAVELVTERAAKALSDTVTPVGLVAVCRLPEVSLDEVLAAAPQLIAVPVQISEPGNAGTLIRVADAMGAAAVVLAGNSVDPYNSKCLRASAGSIFSIPVISEPDEAGAVQRLRAAGLQVLATTVDGEVDLDRADLSMPTAWLFGPEAHGLPGELAAMADHRVHIPMPGRAESLNIASAASICLYQSARAHRAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHU9</accession>
    <name>A0A132PHU9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853471.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24265"/>
    <dbReference type="EnsemblBacteria" id="KWX21582">
        <property type="protein sequence ID" value="KWX21582"/>
        <property type="gene ID" value="AFM11_23890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2136"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="221" mass="23021" checksum="1507D11E61790E82" modified="2016-06-08" version="1">MDTVEYAPGRLADVFGEPSQPTALFWHGMQPDSRAAVRVLAEAVADLDLAVIAPDWNSRNADGGRADLINSVEFARKQADGLILIGWSLGGVAAAGLTLRAAEFDVRVLHTVCLGGAFMAPDPISGGHVLDQVPDGASPASFTLLVGDADDVVPVSAATEFAAALRARDWRVDIVEVAADHGSIAGARYDPAAERYEPADDAATHAVVRDVAARIATAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHV6</accession>
    <name>A0A132PHV6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplT</name>
        <name evidence="8" type="ORF">AFM11_22440</name>
        <name evidence="9" type="ORF">AWC31_08770</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852728.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08770"/>
    <dbReference type="EnsemblBacteria" id="KWX21930">
        <property type="protein sequence ID" value="KWX21930"/>
        <property type="gene ID" value="AFM11_22440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10240">
        <property type="protein sequence ID" value="ORX10240"/>
        <property type="gene ID" value="AWC31_08770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1838"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX10240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="129" mass="14437" checksum="8559F860076DF984" modified="2016-06-08" version="1">MARVKRALNAQKKRRTVLKASKGYRGQRSRLYRKAKEQQLHSLTYAYRDRRARKGEFRKLWISRINAAARANDITYNRLIQGLKAAGIEVDRKNLAEIAVSDPTAFAALVEAAKAALPEDVNAPSGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHY7</accession>
    <name>A0A132PHY7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="7" type="ORF">AFM11_22445</name>
        <name evidence="8" type="ORF">AWC31_08765</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852730.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08765"/>
    <dbReference type="EnsemblBacteria" id="KWX21931">
        <property type="protein sequence ID" value="KWX21931"/>
        <property type="gene ID" value="AFM11_22445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10239">
        <property type="protein sequence ID" value="ORX10239"/>
        <property type="gene ID" value="AWC31_08765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1839"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX10239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="64" mass="7305" checksum="9D7E5A3F76573339" modified="2016-06-08" version="1">MPKAKTHSGASKRFRRTGTGKIVRQKANRRHLLEHKPSKRTRRLDGRTVVATNDNGRINKMLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI98</accession>
    <name>A0A132PI98_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_21395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852317.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04210"/>
    <dbReference type="EnsemblBacteria" id="KWX22070">
        <property type="protein sequence ID" value="KWX22070"/>
        <property type="gene ID" value="AFM11_21395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1627"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="27"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="438" mass="47337" checksum="7080B7D2EB2111B5" modified="2016-06-08" version="1">MTHGKPGREPDPAPRGRSRATRIRWAVAVFCAVGLAINYIDRSAVSVSLPFMTEDFHLTPTEKGLILSAFSWSYALMQIPAGRLIDRFGERVMFGASVLVWSLFTGATGVVNSFGALLGLRLGLGVGEAGAYPAAAKTVSHWFPLRLRSRATSVYDSGARIGSAAATPLIALIIGLWGWRAAFLFAGALGVLWAIGWWAWYRRPEVMSGVNEAELAIIHESHKEQAATNLDPTAKPMRLVELFRRRTVWGMMLGFFCLNFMITFFLTWFPSYLVEERGFDLLKLGVFGMIPPLAAILGSWIGGFVGDYLLARGWSLNRVRKTCLVGGMLVCSVIALAAVAPQAWQALTLMSISYAASAFTIVTIWCLPADVVDSSTVASLGATQNFFSNIGSALSPIVIGALYGATGSFEFPLVLTGVVVVAGALCFGLLIKRVEPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PID6</accession>
    <name>A0A132PID6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852413.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04530"/>
    <dbReference type="EnsemblBacteria" id="KWX22119">
        <property type="protein sequence ID" value="KWX22119"/>
        <property type="gene ID" value="AFM11_21725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1693"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="106" mass="11130" checksum="75AD72D604A29051" modified="2016-06-08" version="1">MPKVVFITLDGASRIVDAQAGESVMAAAVRNGIPGIIGECGGNCSCATCHVYVDDEFISAVGSVGDMEDDLLDLGVADRRPGSRLSCQIQVTEDLDGLTVRMPEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PII4</accession>
    <name>A0A132PII4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="9" type="ORF">AFM11_21955</name>
        <name evidence="10" type="ORF">AWC31_04760</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852491.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04760"/>
    <dbReference type="EnsemblBacteria" id="KWX22160">
        <property type="protein sequence ID" value="KWX22160"/>
        <property type="gene ID" value="AFM11_21955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10600">
        <property type="protein sequence ID" value="ORX10600"/>
        <property type="gene ID" value="AWC31_04760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1739"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="112"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX10600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="342" mass="36935" checksum="9D36AF050A624AD9" modified="2016-06-08" version="1">MNIDMAALHAIEADKGITVDVVVETIKSALLTAYRHTEGHEPDARIDIDRKTGVVKVIARQTDADGNVIHEWDDTPEGFGRIAATTARQVILQRLRDAENEKNYGEFSAREGDIVAGVIQRDARANARGLVVVRMGSETKGSEGVIPSAEQVPGERYEHGDRLRCYVVGVTRGAREPLITLSRTHPNLVRKLFSLEVPEIADGSVEIVAVAREAGHRSKIAVTSRVPGLNAKGACIGPMGQRVRNVMSELSGEKIDIIDYDEDPSRFVANALSPAKVVSVSVIDEAGRAARVVVPDFQLSLAIGKEGQNARLAARLTGWRIDIRSDAAPAPDSDARHGAVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIQ6</accession>
    <name>A0A132PIQ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852553.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04885"/>
    <dbReference type="EnsemblBacteria" id="KWX22191">
        <property type="protein sequence ID" value="KWX22191"/>
        <property type="gene ID" value="AFM11_22125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1773"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="389" mass="42112" checksum="C011D0367BD24B88" modified="2016-06-08" version="1">MTVTLHWFLPTYGDSRFIVGGGHGTPAGAAHSDRDASIDYLASIVRAAETFGFTGALIPTGAWCEDAFITASLLARETTSLAFLVAFRPGLVSPTLSAQMAATFARHAPGRILLNVVVGGEAHEQRAFGDHLDKDARYARCDEFLDVVRRLWAGETVTHRGQYIDVEEASLALPPNPVPPLYFGGSSTAAGPVAARHSDVYLTWGEPPEAVREKIDWIRALGEEQGRKLRFGIRLHTISRDTSEEAWAQADRLVAALDEDTVRTAQQGLARSQSEGQRRMLALHEANRRNGTWSDARSLEIAPNLWSGVGLVRGGAGTALVGSHTEVADRIAEYAAIGIDEFIFSGYPHLEELFWFGEGVVPILRKRGLFDNGARSAAPASIPFVGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIQ7</accession>
    <name>A0A132PIQ7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_20630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852022.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06045"/>
    <dbReference type="EnsemblBacteria" id="KWX22248">
        <property type="protein sequence ID" value="KWX22248"/>
        <property type="gene ID" value="AFM11_20630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1463"/>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1059"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX22248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1169" mass="124991" checksum="D7821FC87895F03F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIX2</accession>
    <name>A0A132PIX2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribodipyrimidine photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_21550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852599.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04365"/>
    <dbReference type="EnsemblBacteria" id="KWX22214">
        <property type="protein sequence ID" value="KWX22214"/>
        <property type="gene ID" value="AFM11_21550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1658"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="443" mass="49654" checksum="686E9DEE2AF88203" modified="2016-06-08" version="1">MPTLLWFRRDLRCHDHPALLDAAQHDGDVLGCYVLDPRLTASSGARRLQYLHAALHELRDSLGGRLLVTRGRPEKRIPAVAHAIGAASVHVSQDFSPFGRRRDDAVRAALGDVPLCATGSPYLVSPGRITKPDGTPYQVFTPFFQAWRRHGWRPPAKSGPDSARWMDPAAVPHGTEIPRATGVLEVAPGESAARAQWVAFVRDDLAGYATDRNRPDLDATSRMSAHLKFGAIHPRTMAADLDGRRTGADAYLRELAFRDFYAAVLHHWPDSAWWNWNRDFDAIETDDGDDAKEAFEAWKAGMTGFPIVDAGMRQLVQTGFMHNRVRMIVASFLVKDLHLPWQWGARWFLDQLVDGDMANNQHGWQWAAGCGTDAAPYFRVFNPTLQGAKFDPDGAYIRRWVPELAHVDDVHKLDGSRPAPYPQPIVDHSQERLEALRRYRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIY8</accession>
    <name>A0A132PIY8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852189.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06465"/>
    <dbReference type="EnsemblBacteria" id="KWX22328">
        <property type="protein sequence ID" value="KWX22328"/>
        <property type="gene ID" value="AFM11_21100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1567"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="418" mass="44415" checksum="4CDCB087E75DC4DD" modified="2016-06-08" version="1">MPDVVFPLDSTKKFTEQEKLGHNRWHPDIPAAVTVKKGDSFRVHCREWFDGAIVNDDSADDILNAPLTTVHVLSGPIAVEGAKPGDLLIVDILDVGPIPQEDSGPLAGQGWGYTGIFPTQNGGGFLTEQFPDAYKAIWDFSGQHATSRHVPGVEFTGIVHPGLMGTAPSAKLLSTWNTREAALIATDPDRVPPLALPPEPQDAILGGLTGDAFTKAAAEAARTAPPRENGGNQDIKNLTKGSRVFYPVFVDGANLSVGDLHFSQGDGEITFCGAIEMGGFIDLRVDVIPGGMETYGVSENAIFMPGNTDPQYSEWLAFSGTSVTLDGEQRYLDSHLSYQRACLHAIDYLTKFGYSPEQAYLLLGAAPIEGRLSGVVDIPNACATVYIPTAIFDFPVAPSAAGPVKIDPGIGAPHSSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ15</accession>
    <name>A0A132PJ15_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_21070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852178.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06435"/>
    <dbReference type="EnsemblBacteria" id="KWX22325">
        <property type="protein sequence ID" value="KWX22325"/>
        <property type="gene ID" value="AFM11_21070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1561"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="186" mass="20162" checksum="9F297E895620E93C" modified="2016-06-08" version="1">MARTPDPAKREELLQAVVGYLEERGIGDMSLAPMAQALGTSKRMLLYYFGDRAELLAQALDASRPRLGEMFHDVTTPAEFVEAARNLWRELTRGAEHRSVRLLLQVLSLAVTDPETYGPSARDAVDVMVEPISLALRAIGYGDEAAARATLVVSGLRGLCQDALVTKDRSRVDAAAELLIAAAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJQ8</accession>
    <name>A0A132PJQ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_18890</name>
        <name evidence="7" type="ORF">AWC31_14980</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851554.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_14980"/>
    <dbReference type="EnsemblBacteria" id="KWX22580">
        <property type="protein sequence ID" value="KWX22580"/>
        <property type="gene ID" value="AFM11_18890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17741">
        <property type="protein sequence ID" value="ORX17741"/>
        <property type="gene ID" value="AWC31_14980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1113"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="15"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX17741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="220" mass="23588" checksum="BF097788C39AA64A" modified="2016-06-08" version="1">MQYLLTHLDDLWALTVIHLRLSLVPIVLGLLIAVPLGALVQRTTTLRRLTTVTASIIFTIPSLALFVVLPLIIPTRILDEANVIVALTLYTTALLVRAVPEALDAVPEHVRDAATAIGYRPLVRMLKVELPLAIPVLVAGVRVVAVTNISMVSVGSVIGIGGLGTWFTEGYQSNKSDQIIAGIIAIFVLAIVIDTLIMLIGKAITPWTRQPRASKVKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJS3</accession>
    <name>A0A132PJS3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18900</name>
        <name evidence="2" type="ORF">AWC31_14990</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851557.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_14990"/>
    <dbReference type="EnsemblBacteria" id="KWX22581">
        <property type="protein sequence ID" value="KWX22581"/>
        <property type="gene ID" value="AFM11_18900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17742">
        <property type="protein sequence ID" value="ORX17742"/>
        <property type="gene ID" value="AWC31_14990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1115"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009467">
        <property type="entry name" value="Glycolipid-bd_prot_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06475">
        <property type="entry name" value="Glycolipid_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX17742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="202" mass="22183" checksum="153CF71727791EA9" modified="2016-06-08" version="1">MSEEARTSETESAWPAVLTWRAHDVPRMESVRVQLSGNRIKAYGRIVAAATTSHPAFSASYDLVTDESGATKRLSLTVTLAERERQLSIARDEESMWLVQDHTQTKRSDYGGAVDVDVIFSPFFNALPIRRMGLHQRADSVTLPVAYVRLPELTVETATISYSSAGADLEAGIKLHSPVAETTITVDSDGFIVDYPGLAERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK27</accession>
    <name>A0A132PK27_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06520"/>
    <dbReference type="EnsemblBacteria" id="KWX22372">
        <property type="protein sequence ID" value="KWX22372"/>
        <property type="gene ID" value="AFM11_21155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1578"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="194"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="422" mass="44829" checksum="848B7738B843AEDF" modified="2016-06-08" version="1">MRELRDQFSGALASAVDLYRDLHRHPELSMQEHRTQEVLRAALNRTSAAVRECADTGLVAVLRNGRGPVIAMRADIDALPLPEFTGLAYASRAVGTLPDGRQTPVMHACGHDVHASALVAALTQLDRRRDTWSGTLVAVFQPGEETGVGAAAMIEDGLFDATGMPDAIYAQHVTSGPIGLLVCRPGYFLSHQRSWRITVDGHGGHASRPHLAKDPVVASAAMIVRLQAIVSREIDPLRMAVLSVGSIHGGTASNIIPDRVTFTVTTRNYEPAVGDRLVSAMHRVIAAEAAASEVHAQIDAVSEIPACSNDPDETANVCRGLASLFGAAAVRSPDDPLPASDDFSQYSRQLGIPSVIWNFGCQEPSLFGDGDDVPRNHTSRFAPHPDAVTVGAAAAVAVVRERCAIAGSKMQSLRDGAEVGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK54</accession>
    <name>A0A132PK54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851682.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15385"/>
    <dbReference type="EnsemblBacteria" id="KWX22644">
        <property type="protein sequence ID" value="KWX22644"/>
        <property type="gene ID" value="AFM11_19300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1193"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="PTHR10801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="466" mass="52667" checksum="D0E5570D791260FA" modified="2016-06-08" version="1">MSVASTDAQAVHAAGVERLLDSYRAIPPTATVRLAKPTSNLFRKRAKSTAKGLDTSGLTGVIGVDAAAQTADVAGMCTYEDLVAATLPYGLAPLVVPQLKTITLGGAVTGLGIESTSFRNGLPHESVLEMDILTGSGEIVTASPHQNADLFRAFPNSYGTLGYSTRLRIELEPVTPFVALRHLRFHTLTDLISTMDRIIETGGLNGERVDYLDGVVFSAAESYLCVGFKTKTAGPVSDYTGQQIYYRSIQHPGGNGAEKHDRLTIHDYLWRWDTDWFWCSRAFGAQHPLIRRFWPRRYRRSSFYWKLIGYDQRFNIADRIEKRQGRPPRERVVQDIEVPIERCVEFLDWFLENVPIEPLWLCPLRLRDDSNQGAAWPLYPLRAHHTYVNVGFWSSVPVGPEEGYTNRRIERKVDELEGHKSLYSDAFYSREQFDDLYGGEAYKTVKKMYDPDSRLLDLYSKAVQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK97</accession>
    <name>A0A132PK97_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851767.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22684">
        <property type="protein sequence ID" value="KWX22684"/>
        <property type="gene ID" value="AFM11_19530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1239"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="229" mass="24277" checksum="C1D931CB6F149232" modified="2016-06-08" version="1">MSITIAANPYVWPYDGDIPSGRTALINIDWQVDFCGEGGYVDAMGYDLSLVRTPLGPAREVLAAARAAGLFVIHTREGHRPDLSDLPANKRWRSAQIGAEIGSSGPCGRILTRGEPGWQLVPEMAPLPGEPVIDKPGKGSFYATDLDLILRGNGITHIIFTGITTDVCVHTTMRDANDRGYECLVVSDATGATDYANHVAALNMITMQGGVFGAHATSADVVAALKGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKN5</accession>
    <name>A0A132PKN5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylglutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17565</name>
        <name evidence="4" type="ORF">AWC31_05085</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851407.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05085"/>
    <dbReference type="EnsemblBacteria" id="KWX22909">
        <property type="protein sequence ID" value="KWX22909"/>
        <property type="gene ID" value="AFM11_17565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10702">
        <property type="protein sequence ID" value="ORX10702"/>
        <property type="gene ID" value="AWC31_05085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.868"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010167">
        <property type="entry name" value="NH2A_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602">
        <property type="entry name" value="PTHR30602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX10702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="160" mass="17946" checksum="E1B0C4D30B75CD17" modified="2016-06-08" version="1">MRRARTSDVPAIKGLVDIYAGKILLEKNLVTLYEAVQEFWVAELDGELVGCGALHVLWSDLGEVRTVAVHPKVRGAGVGHLLVERLLDVARDLHLQRIFVLTFEVEFFSRHGFEEIDGTPVTAEVFEEMCRSYDTGVAEFLDLSYVKPNTLGNTRMLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKW9</accession>
    <name>A0A132PKW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-oxalocrotonate tautomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851699.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15425"/>
    <dbReference type="EnsemblBacteria" id="KWX22652">
        <property type="protein sequence ID" value="KWX22652"/>
        <property type="gene ID" value="AFM11_19340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1201"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-oxalocrotonate_tautomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="65" mass="7457" checksum="5E1B127754B49580" modified="2016-06-08" version="1">MPNVEVTIAQGRSPEQIRAMMHEVHEAVLRTVDTQPEHIRVIVREVPRTHWATGDLTIAEMKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL96</accession>
    <name>A0A132PL96_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850943.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01890"/>
    <dbReference type="EnsemblBacteria" id="KWX23116">
        <property type="protein sequence ID" value="KWX23116"/>
        <property type="gene ID" value="AFM11_17310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.815"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026353">
        <property type="entry name" value="Hypoxan-DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04274">
        <property type="entry name" value="hypoxanDNAglyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="162" mass="17934" checksum="83321C6CBADA6F43" modified="2016-06-08" version="1">MADILYGLAPIADARSRVLILGNMPSAMSLASQQYYGNPRNAFWRITAEILGFDHQAPYLERVAALQNHGVAVWDVLRSCRRVGSLDSAVERDTMVPNAFDAFFAKHDRITRLVFNGAAAEANYRRLVAEPPMPTVRVPSTSPAQTMRYADKLAAWRAALAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLB3</accession>
    <name>A0A132PLB3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850993.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19910"/>
    <dbReference type="EnsemblBacteria" id="KWX23140">
        <property type="protein sequence ID" value="KWX23140"/>
        <property type="gene ID" value="AFM11_16410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.630"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="20913" checksum="575D6D5ED149D2DF" modified="2016-06-08" version="1">MAGERPGGRTAAVREAVLRAAADLLIETGLEGLELTAVAERAEVGKSTVYRRWGSVPALVADMLADMAEQSSPRAESGSLRTDLRANATLVRRTLTDPRQGPLFKAIIAAATCDRRTADALQVFYDRRIAEWAGCVVDAIDRGEAPPGTDAAAAIRQVSAPLYYQFLTSTRPLTAADAERAVDATIAAIAAGVYVAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLF2</accession>
    <name>A0A132PLF2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18025</name>
        <name evidence="3" type="ORF">AWC31_12095</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851232.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12095"/>
    <dbReference type="EnsemblBacteria" id="KWX22832">
        <property type="protein sequence ID" value="KWX22832"/>
        <property type="gene ID" value="AFM11_18025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18729">
        <property type="protein sequence ID" value="ORX18729"/>
        <property type="gene ID" value="AWC31_12095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.961"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021443">
        <property type="entry name" value="DUF3093"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11292">
        <property type="entry name" value="DUF3093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="159" mass="17640" checksum="67E4D9ECB6269631" modified="2016-06-08" version="1">MSDTRATTQTVRYRERLWVPWWWTLPAAILAGIIALEVGMGVSGMPKWVPYAVLFPVAAAVLMWFSKTELRVVSRPGGETEVWVGQAHLPTSVISRTAEVPRSAKSAALGRQLDPAAYVVHRAWVGPMVLLVLDDPDDPTPYWLVSTRHPDRLLSALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLM7</accession>
    <name>A0A132PLM7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugal transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850314.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16090"/>
    <dbReference type="EnsemblBacteria" id="KWX23255">
        <property type="protein sequence ID" value="KWX23255"/>
        <property type="gene ID" value="AFM11_15675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7258"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022399">
        <property type="entry name" value="HlxAse/secretion_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03819">
        <property type="entry name" value="heli_sec_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="58"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="386" mass="40255" checksum="328CE792227A2F13" modified="2016-06-08" version="1">MSTSLIDRVRERLVAETAPLSPDVVAAAIRAESGGLLGDTEVLSNLRVLQTELTGAGILEPLLYADGTTDVLVTAPDAVWVDDGDGLRRTGIRFADEAAVRRLAQRLALLAGRRLDEAQPWVDGQLSGIGAFTVRLHAVLPPVAAGGTCVSLRVLRPATQNLDSLTRSGAIAPAAAELLRAIIAARLAFLISGGTGCGKTTLLSAALGGVAEHERIVCVEDAAELAPSHPHVVKLVARGANVEGVGEITVRDLVRQALRMRPDRIVVGEVRGAEVVDLLAALNTGHDGGAGTVHANSPAEVPARLEALGALGGLDRPALYSQLAAAVQVLLHVGRDRTGRRRLAEIAVLRRTGDGALDVLTAWHADTGFGRGADILQQLIVDRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLS7</accession>
    <name>A0A132PLS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850416.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16545"/>
    <dbReference type="EnsemblBacteria" id="KWX23305">
        <property type="protein sequence ID" value="KWX23305"/>
        <property type="gene ID" value="AFM11_15970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7319"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="253" mass="28135" checksum="E90803C889667340" modified="2016-06-08" version="1">MVTDLLTHRGGHGAPIVLVHGLMGRGSTWSRQLPWLTALGEVYTYDAPWHRGREVPDPYPISTERFVADLGDAVATLARPAALVGHSMGALHSWCLAASRPDLVTAVVVEDMAPDFRGRTTGPWEPWVHALPVEFRSAQEVYDEFGPVAGQYFLEAFDRTDTGWRLHGHPQWWLDIAAEWGRRDYWGQWRSVQVPTLLLEAGNSVAPAGQMRQMGETGHRTTYLHVAGAGHLIHDEQPQIYRDAVTAFLAALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMG9</accession>
    <name>A0A132PMG9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall synthesis protein Wag31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Antigen 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_14355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DivIVA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849800.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18465"/>
    <dbReference type="EnsemblBacteria" id="KWX23464">
        <property type="protein sequence ID" value="KWX23464"/>
        <property type="gene ID" value="AFM11_14355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6979"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="88" mass="9779" checksum="52254E8211649E4C" modified="2016-06-08" version="1">MSAMSRVLTAEDVRNAEFSKPPIGKRGYDKKSVDDFLQLVARRLDGLGHLSADDVRNIGFPKPPMFQRGYDEDEVDALLDAVVATLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMP9</accession>
    <name>A0A132PMP9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850078.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18430"/>
    <dbReference type="EnsemblBacteria" id="KWX23595">
        <property type="protein sequence ID" value="KWX23595"/>
        <property type="gene ID" value="AFM11_14390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6986"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="206" mass="22540" checksum="A8D3CBE64C7E8569" modified="2016-06-08" version="1">MSSASDDVWEVMSTCRTIRRFTDEPVDDAVLNRCLQAAAWAPSGANAQAWRFVVLRSPEQRAVVAKAAAQALAVIEPVYGVSRPADDDTSRRARTNRATYELHDRAGEFTSVLFTQQKFPTASELLLGGSIFPAMQNFLLAARAQGLGACLTSWASYGGEQLIRDAVGVPPDWMLAGHVVVGWPRGRHGPVRRRPLGELVATDYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMV8</accession>
    <name>A0A132PMV8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkyl hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_12795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849077.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03115"/>
    <dbReference type="EnsemblBacteria" id="KWX23671">
        <property type="protein sequence ID" value="KWX23671"/>
        <property type="gene ID" value="AFM11_12795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6651"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453426" evidence="4">
        <location>
            <begin position="32"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="51"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="210" mass="22589" checksum="8692DAFA0DE6C724" modified="2016-06-08" version="1">MRGFVARGCIGVLAALLALLTGCSTGDDAVAQGGTFEFVAPGGKTDIFYDPPEKRGRPGALTGPDLLDPTKTISLDDFAGKVVVINVWGQWCGPCRTEITELQQVYEATRSAGVAFLGIDVRDNNREAAVDFVTDRKVTFPSIYDPPMRTMIAFGGKYPTTVIPSTVVLDRQHRVAAVFLRELLAEDLQPLVLRLAAEPAEAPAPQESQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMZ1</accession>
    <name>A0A132PMZ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09420"/>
    <dbReference type="EnsemblBacteria" id="KWX23412">
        <property type="protein sequence ID" value="KWX23412"/>
        <property type="gene ID" value="AFM11_14050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6914"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="206" mass="22462" checksum="0AA48714B00060F1" modified="2016-06-08" version="1">MSMTDSPLDGLLARAGGVRGLVYSGLPVTTFALTSAVFGRIPATIAALTTAALVLGWQLLRRESTRPALWGFAGVAVCAGLALVTGQAKDFYLPGIWMYFLTATLFTVSIVVRRPLVGVVWAWVTGRDGTWRRIPRVRLAFDVVTAVMATVSWSRFLVQYYLYDTDQESLLAIARIAMGWPLFLVTTAAILLVVRYAIRTLAQSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNC0</accession>
    <name>A0A132PNC0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1942 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849434.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03810"/>
    <dbReference type="EnsemblBacteria" id="KWX23793">
        <property type="protein sequence ID" value="KWX23793"/>
        <property type="gene ID" value="AFM11_13565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6808"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015250">
        <property type="entry name" value="MPT63-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09167">
        <property type="entry name" value="DUF1942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453203" description="DUF1942 domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1942" evidence="4">
        <location>
            <begin position="38"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="344" mass="32608" checksum="6A68EA13EBAF11C6" modified="2016-06-08" version="1">MKISTFTAAVAAALATAGAAGTAGMATAFADAAATASSQLGSQAKLENGAVVQAWTISDLKPSSDTIPYAVRGTLWEATATDEAIQGSVTPIVSNLNARAADGENYRVLFQVATPQGVNPATLAQGQKTTGKVYFDVTGDKPTSVVYNAGGQDLATWTAPAPSAPAPSGSRSVPIRSAPVATAPAAPVTSTPAPAAPAPVPAANTPAPAATAPGAGTRATDLPGSTVDAPLPEGSQGTPLPADAPGTPLPADAPAPEGSQGTPLPAGVQVAPAPAAPAPAAPAPAAPAPGAPAAPAPAPAPAAPPAPGAPAPTTPVPAGTEAPPLTAGGIPTLVPAAVQGTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PND8</accession>
    <name>A0A132PND8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="9" type="ORF">AFM11_14995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850006.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17910"/>
    <dbReference type="EnsemblBacteria" id="KWX23562">
        <property type="protein sequence ID" value="KWX23562"/>
        <property type="gene ID" value="AFM11_14995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7109"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="151" mass="15974" checksum="2AB6AE20562232D2" modified="2016-06-08" version="1">MKLILTAEVEHLGVAGDTVEVKDGYGRNYLLPRGLAIVASRGAERQADEIRRARESKAIRGLEHANELKTALENLGEVSLPVNAAADTGKLFGSVTAADVVSVIKKAGGPNLDKRTVQLPKAHIKSVGTHPVTVKLHTGVEAKVSLNVIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNH2</accession>
    <name>A0A132PNH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849535.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23843">
        <property type="protein sequence ID" value="KWX23843"/>
        <property type="gene ID" value="AFM11_13875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6871"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="59"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="395" mass="43528" checksum="0598B0F3A3398184" modified="2016-06-08" version="1">MTLRDRQLIAGFDDLDVSRMQRRTGVKWARATQAAALPAWVADMDFPLAPPIRRALTELVDSGDLGYPNWLAGTPLRAEFAHRMNDRYGWQLDPSAVREQTDLIQALQLILRLSTTPGDAVAIQTPNYPPFLATLRTMRLKTVELPFTDTDTGWALDFDEIQRAFQEHRPRVLILVNPHNPTGRVHTRAELQRIAAIADEFDLLVISDEIHAELTYAPHQHIPFASVSSAAAARTVTITSAGKAFNIAGLRCAVVHYGDRSLLERRDAEPPDLYGAVSVPGVVATLAAWRHGGEWQDTLIGVLERNRDRVHGTLADAVPGARHHKPEATYLSWFDVSRLGIDDPVDRILRTGGVMVDGGSAFGHSGAHRIRINFATAAPILDRILSGIADGLTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNI7</accession>
    <name>A0A132PNI7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_10995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847998.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31260"/>
    <dbReference type="EnsemblBacteria" id="KWX23906">
        <property type="protein sequence ID" value="KWX23906"/>
        <property type="gene ID" value="AFM11_10995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6275"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="PTHR11271:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="64"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="454" mass="49086" checksum="DE9FD30FCC495A8D" modified="2016-06-08" version="1">MTRAYRGHLMHIGGNPELADVRDWLVSEPDGVVVVDDTGRITYSGAYADRPGDDAETVDFRPAFLLPGFVDTHIHFPQTYCTDAYGGGRLLDWLARCVFPAEAKLADPAYAQQAARDFCRRRISVGTTTALVFGSAFPHAQDALFSESIRTGLRTISGRGIQTVGPPSAGPLLTDETTAISLAVAEIDRWHGADTGDPATAFVHAAVVPRFALSVTAQTLHALGEVYDSVRDRGVYFHTHLNENVDEVAAVHETYGVRTYLDTYDGRFGGGSTPAGKTLLGPRSVLAHAVHCTADELARMAETATSIAHCPTSQLFLGSGVMPWRSTVRSRVNVSLGTDVSAGDEWLMPRVLNDCFKVHMSEPGDHAVALHPAELLFTATLAGARALDLEARIGNLDVGKEADFVVVDPHHQELLAETLAQIENGDRDRLLFTLLMGMRDDAVVQVYVKGRKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNK7</accession>
    <name>A0A132PNK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848077.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30735"/>
    <dbReference type="EnsemblBacteria" id="KWX23929">
        <property type="protein sequence ID" value="KWX23929"/>
        <property type="gene ID" value="AFM11_11165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6310"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="139" mass="14494" checksum="1BA29F39C389FD40" modified="2016-06-08" version="1">MATQTENVIYTAKTHTTGGRQGESYSSDGNLDIQLTPPGGNGSGTNPEQLFAAGWSACFLSAMGLTAGKHNVKLPTDTAVDAEVDLLNTDGAFSLQARLNVTIPGVDRETAQAIVDDAHQVCPYSKATRGNVDVTLNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNV9</accession>
    <name>A0A132PNV9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848398.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30290"/>
    <dbReference type="EnsemblBacteria" id="KWX24029">
        <property type="protein sequence ID" value="KWX24029"/>
        <property type="gene ID" value="AFM11_11735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6425"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="106" mass="11708" checksum="F5CC47DDB0BE255A" modified="2016-06-08" version="1">MAEVRDIPDARQYEITVDGEHAGLIDYVDTEGQRILYHTEIDDKFGGQGLAGTLVEQALADTRAAGKRIVPVCPYIAKYVKRHHDYDDILDPVTPDAVATVKARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNW3</accession>
    <name>A0A132PNW3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848389.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30305"/>
    <dbReference type="EnsemblBacteria" id="KWX24026">
        <property type="protein sequence ID" value="KWX24026"/>
        <property type="gene ID" value="AFM11_11720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6422"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021798">
        <property type="entry name" value="AftD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11847">
        <property type="entry name" value="DUF3367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1360"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1395" mass="146104" checksum="E8C376253D248DBD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNW8</accession>
    <name>A0A132PNW8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphotriesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_11740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="2">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848401.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30280"/>
    <dbReference type="EnsemblBacteria" id="KWX24030">
        <property type="protein sequence ID" value="KWX24030"/>
        <property type="gene ID" value="AFM11_11740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6426"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00530">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017947">
        <property type="entry name" value="AryldialkylPase_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01322">
        <property type="entry name" value="PHOSPHOTRIESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1 3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="323" mass="35463" checksum="F3B060E961592B7D" modified="2016-06-08" version="1">MPTVNTASGTIDTADLGVTLMHEHVFIMSTELTQNYPESWGDEAGREADAIARLNELKARGVDTIVDLTVIGLGRYIPRIARIAAATDLNIVVATGLYTYNDIPMTFHFRGPAMGGSEPMTEMFVRDIDHGIADTGIKAAILKCATDEPGVTPGVERVLRAVAQAHRQTGVPISTHTHAATRRGLEQQQIFADEGVDLSRVVIGHSGDTTDIGYLEELIANGSYIGMDRFGVDVFLPFAERVQTVATMCERGHADRMVLSHDTWCYFDALPDEMTSKALPNSHYLHIHNDVIPALKDRGVTDEQINTMLVDNPRRIFDRKGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP64</accession>
    <name>A0A132PP64_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848563.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24083">
        <property type="protein sequence ID" value="KWX24083"/>
        <property type="gene ID" value="AFM11_12025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6484"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="120" mass="13228" checksum="E55CE37C82355189" modified="2016-06-08" version="1">MTDERSDVTSETPEEGGPDDTLSPSEATDSDEVANADGDEVVDPPEDWQAADETEPEESLDRKLEAEEPDVSAQEPAPRDIDETAAAPRDVEIVHPDDRREDRPDDRPDDGEESLFPVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPF5</accession>
    <name>A0A132PPF5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">nadE</name>
        <name evidence="8" type="ORF">AFM11_09515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847143.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05710"/>
    <dbReference type="EnsemblBacteria" id="KWX24226">
        <property type="protein sequence ID" value="KWX24226"/>
        <property type="gene ID" value="AFM11_09515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5940"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041856">
        <property type="entry name" value="NAD+_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="366"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="490"/>
            <end position="493"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="683" mass="75205" checksum="E22E59BAC23E422C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPL7</accession>
    <name>A0A132PPL7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848783.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09570"/>
    <dbReference type="EnsemblBacteria" id="KWX24147">
        <property type="protein sequence ID" value="KWX24147"/>
        <property type="gene ID" value="AFM11_12410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6561"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="222" mass="23035" checksum="7FB0C95D1E06E577" modified="2016-06-08" version="1">MAIASPVSERLTVTALLLLTLATGIVDAISVLVLGHVFVANMTGNVIFLGFWFVPHSGVDLTAAVVAFAGFVAGTVLGGRLARHIDSHVRTWLTVALGVEVVMLTALSVLAGTGVLRYHDNSKLFLIAGLALTFGIQNATARQFGIQELSTTVLTSTIVGIGFDSRLAGGTGQREKLRYAVVATMCGGAVIGATLSRFTVAPVIALAAVVVAISALIFRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ05</accession>
    <name>A0A132PQ05_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_10690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847753.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19205"/>
    <dbReference type="EnsemblBacteria" id="KWX24420">
        <property type="protein sequence ID" value="KWX24420"/>
        <property type="gene ID" value="AFM11_10690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6178"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="64" mass="6964" checksum="E2A7C1015F552CDC" modified="2016-06-08" version="1">MRVRVDEDRCAGHGMCLTLCPEVFEMSEDGWAVADPEGVPAGLEDAAREAVENCPERAISEIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQY8</accession>
    <name>A0A132PQY8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_08815</name>
        <name evidence="7" type="ORF">AWC31_13555</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846628.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13555"/>
    <dbReference type="EnsemblBacteria" id="KWX24750">
        <property type="protein sequence ID" value="KWX24750"/>
        <property type="gene ID" value="AFM11_08815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18341">
        <property type="protein sequence ID" value="ORX18341"/>
        <property type="gene ID" value="AWC31_13555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5611"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="5">
        <location>
            <begin position="163"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX18341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="282" mass="29704" checksum="3767FD5D2A9C70C0" modified="2016-06-08" version="1">MSDPKYGYIGLGNMGAPMAKRLVEWPGGLTVFDVRTEAMTPLVELGATVADDVGDVAQADIISITVLNDEQVRDVVGQLSEHVKPGTVIAIHSTISPETAVELADQLRPKDIHIVDAPVSGGGAAAEKGELAVMVGADREVYERIKPAFKQFASMVIHAGEPGAGTRMKLARNMLTFVGYAAACEAMKLAEASGINLQQLGRVVRHTDALTSGPGAIMVRDNMAELTPDNFLYDSFTHARGLGEKDLSLALGLGDAVGVDLPLAQVALQRLADGLGVPHTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR80</accession>
    <name>A0A132PR80_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_07650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846910.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22145"/>
    <dbReference type="EnsemblBacteria" id="KWX24836">
        <property type="protein sequence ID" value="KWX24836"/>
        <property type="gene ID" value="AFM11_07650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5379"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003510">
        <property type="entry name" value="Fumarate_red_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02300">
        <property type="entry name" value="Fumarate_red_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000180">
        <property type="entry name" value="FrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="124" mass="14032" checksum="FBF47A66DDA5CEF4" modified="2016-06-08" version="1">MPEYRAPMPMLWWAKRRSYLVFMLRELSSVFVAWSVVYLAVGVWAVGGGNYQQFLDFSANPVVVVLNVVTLCFLLLHTITWLGLAPHAIVIHLRGRRVPERTVLAGHYVAWLVVSAIIAWVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRE0</accession>
    <name>A0A132PRE0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_05605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845040.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24918">
        <property type="protein sequence ID" value="KWX24918"/>
        <property type="gene ID" value="AFM11_05605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4311"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="20981" checksum="E0FFCDF7F893704C" modified="2016-06-08" version="1">MREPVGKLSPALLAATVQTLRQSGPRQFSLTAVADAAGVSRGTVHNALGTRERAIEIALEHLTSGFLEALAVQVQRADSLAGQVAAAAVLICAHRRQSDAVSPRGINESILVLLLRNTGDDLIRQSIDFWKPLIRAAQARGEVDARLTPARAAEWIVRLLFSFELLPPMGVNLDSARAVRRFVSDHIIDGLGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRF6</accession>
    <name>A0A132PRF6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_05735</name>
        <name evidence="9" type="ORF">AWC31_11595</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000002">
        <property type="protein sequence ID" value="ORX19208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845082.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11595"/>
    <dbReference type="EnsemblBacteria" id="KWX24938">
        <property type="protein sequence ID" value="KWX24938"/>
        <property type="gene ID" value="AFM11_05735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19208">
        <property type="protein sequence ID" value="ORX19208"/>
        <property type="gene ID" value="AWC31_11595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4338"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX19208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="102" mass="10452" checksum="B019CD9C5A548EBB" modified="2016-06-08" version="1">MTITGIISAILIGIVVGVIGRLVVPGRQPIGFLVTILVGIVSAFIGSAIARALGIPTVTNGIDWLELLVQVIVAALGVALVAALMGRRRTGIMGGRRSGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRN8</accession>
    <name>A0A132PRN8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">AFM11_06045</name>
        <name evidence="9" type="ORF">AWC31_29615</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845180.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29615"/>
    <dbReference type="EnsemblBacteria" id="KWX24993">
        <property type="protein sequence ID" value="KWX24993"/>
        <property type="gene ID" value="AFM11_06045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13925">
        <property type="protein sequence ID" value="ORX13925"/>
        <property type="gene ID" value="AWC31_29615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4401"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX13925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="160" mass="16259" checksum="43A94552D14AD7EF" modified="2016-06-08" version="1">MSGGAGVPELPQIDASNVKLAIVASTWHTKICDALLDGARKVAADAGIAEPTVVRVLGAIEIPVVAQALAATHDAVVALGVVIRGQTPHFDYVCDAVTQGLTRVSLDASTPVANGVLTTDTEEQALDRAGLPSSTEDKGAQAAAAALSTALTLRELRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRW4</accession>
    <name>A0A132PRW4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05730</name>
        <name evidence="3" type="ORF">AWC31_11590</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000002">
        <property type="protein sequence ID" value="ORX19207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845080.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11590"/>
    <dbReference type="EnsemblBacteria" id="KWX24937">
        <property type="protein sequence ID" value="KWX24937"/>
        <property type="gene ID" value="AFM11_05730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19207">
        <property type="protein sequence ID" value="ORX19207"/>
        <property type="gene ID" value="AWC31_11590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4337"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX19207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="157" mass="17576" checksum="66F617E432A6AC8F" modified="2016-06-08" version="1">MTNALNLNAPVDTLAMDFTREFNAPVAALFRAHAEPDLVKQWLGPHGLEMQIERWDFETGGGYRYVHSDQSGEYRFNGVFHTVRPNELIIQTFEFEGAPDMVNIEFMWFEDLGGGRSSLRGRSICPNTDARDALLSSGMEGGMVDGYDKLDALLPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS24</accession>
    <name>A0A132PS24_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpA</name>
        <name evidence="9" type="ORF">AFM11_06955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845515.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28695"/>
    <dbReference type="EnsemblBacteria" id="KWX25151">
        <property type="protein sequence ID" value="KWX25151"/>
        <property type="gene ID" value="AFM11_06955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4590"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="262" mass="26998" checksum="E648F95D199D9448" modified="2016-06-08" version="1">MSRLAELFDTCRAEGRAALIGYLPTGFPDVPTSIAAMTTMVESGCDLVEVGVPYSDPGMDGPTIAAATEAALAGGVRVRDTLAAVEAISNAGGRAVVMTYWNPVLRKGVDTFARDLAAAGGYGLITPDLIPEEADEWFAASEAHKLDRIFLVAPSSTPERLAATVQASRGFVYAASTMGVTGARDAVSSAAPELVRRVREVSDIPVGVGLGVRSGEQAAQIGSYADGVIVGSALVSALQSGLDSVRALTEELANGVRQRISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS67</accession>
    <name>A0A132PS67_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="8">MTHase</shortName>
            <ecNumber evidence="3 8">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 8">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_06750</name>
        <name evidence="15" type="ORF">AWC31_28900</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3 8"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845442.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28900"/>
    <dbReference type="EnsemblBacteria" id="KWX25114">
        <property type="protein sequence ID" value="KWX25114"/>
        <property type="gene ID" value="AFM11_06750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13808">
        <property type="protein sequence ID" value="ORX13808"/>
        <property type="gene ID" value="AWC31_28900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4549"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="13">
        <location>
            <begin position="99"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="242"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="306"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="376"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX25114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX13808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="580" mass="64209" checksum="64E3C1574071EB89" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSB1</accession>
    <name>A0A132PSB1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845685.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17475"/>
    <dbReference type="EnsemblBacteria" id="KWX25200">
        <property type="protein sequence ID" value="KWX25200"/>
        <property type="gene ID" value="AFM11_07240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4648"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="309" mass="33242" checksum="CCE94D56AF5D9D54" modified="2016-06-08" version="1">MDVADLNFFLAVARTGGVSRAATELLTVQSNVSSRIRALEDELGVALFRRHARGMTLTASGQLLVPYAERITQLMRELTQVVRDEGDPSGRVSIGSMESTAGLRLPKVLSSFSADCPKVDLTLSIDTTDALIGQVLDQRLDGAFVCGPVRDPELAAEPVFLEQLVVVGDASVVDLDGALMRRCPPRILVLKAGCAYRGRLEKLYEDRDLPAPSILELSNLDGILGCVAAGMGTTLLPLAVVTASPLASTLTVHHPPPEIARAQTVFVRRRDAVETPAIARFLACAREATSRELLQAVDRHTVEPDRLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSD0</accession>
    <name>A0A132PSD0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ileS</name>
        <name evidence="14" type="ORF">AFM11_06665</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845376.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29010"/>
    <dbReference type="EnsemblBacteria" id="KWX25097">
        <property type="protein sequence ID" value="KWX25097"/>
        <property type="gene ID" value="AFM11_06665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4532"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="706"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="624"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX25097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1046" mass="117669" checksum="57F6F39378F90A00" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSH9</accession>
    <name>A0A132PSH9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_06495</name>
        <name evidence="4" type="ORF">AWC31_29180</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845859.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29180"/>
    <dbReference type="EnsemblBacteria" id="KWX25255">
        <property type="protein sequence ID" value="KWX25255"/>
        <property type="gene ID" value="AFM11_06495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13956">
        <property type="protein sequence ID" value="ORX13956"/>
        <property type="gene ID" value="AWC31_29180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4492"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045745">
        <property type="entry name" value="HTH_58_Actinobacteria-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19575">
        <property type="entry name" value="HTH_58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_58" evidence="2">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX13956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="64" mass="7189" checksum="8D7E9ECDA36F08CD" modified="2016-06-08" version="1">MKETNKTRDELLNELRRAYEGGASIRSLVARTGRSYGSIHSLLRESGTTMRSRGGPNHRTKTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSL0</accession>
    <name>A0A132PSL0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_06160</name>
        <name evidence="12" type="ORF">AWC31_29515</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845215.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29515"/>
    <dbReference type="EnsemblBacteria" id="KWX25012">
        <property type="protein sequence ID" value="KWX25012"/>
        <property type="gene ID" value="AFM11_06160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13909">
        <property type="protein sequence ID" value="ORX13909"/>
        <property type="gene ID" value="AWC31_29515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4424"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX25012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX13909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="77" mass="8113" checksum="AD8ACA23FD7B7D24" modified="2016-06-08" version="1">MELALQIVLVVTSVLVVLLVLLHRAKGGGLSTLFGGGVQSSLSGSTVVEKNLDRLTFFVTGIWVVSIIGVALQIKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSZ1</accession>
    <name>A0A132PSZ1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_03890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844250.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21275"/>
    <dbReference type="EnsemblBacteria" id="KWX25415">
        <property type="protein sequence ID" value="KWX25415"/>
        <property type="gene ID" value="AFM11_03890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2656"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="315" mass="33315" checksum="3DD73F8A48E467E3" modified="2016-06-08" version="1">MTTPPKAPEVPIPYTAVVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVAAEAAEAGAERLIIITSEGKDGVVAHFVEDLVLEGTLEARGKKTMLEKVRRAPALIKVESVVQAEPLGLGHAVSCVEPALSPDEDAIVVLLPDDLVLPTGVLETMSKVRAKRGGSVLCAIEVPGDKISAYGVFDVEPVPDAANPNVLRVKGMVEKPKAEDAPSPYAAAGRYVLDRAIFDALRRVTRGAGGEIQLTDAIALLIEEGHPVHVVVHRGARHDLGNPGGYLKAAVDFALERDDYGPELRQWLVERLGLAEREVGGSTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT62</accession>
    <name>A0A132PT62_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_03695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844152.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21460"/>
    <dbReference type="EnsemblBacteria" id="KWX25387">
        <property type="protein sequence ID" value="KWX25387"/>
        <property type="gene ID" value="AFM11_03695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2615"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="303" mass="32817" checksum="9CFFA379BA79372B" modified="2016-06-08" version="1">MIRSDNDSWDLASSVGATATVVAAQRAIAARGPDPLIHDPYAEPLVRAVGSDTSIRMLDAPTDEESGAYGLKQVAEAMAVRTRFFDKLFADAAAAGVRQAVILASGLDTRAYRLEWPAGTVVYEIDQPAVIEFKTNTLAGLGAYPSAERRTISIDLRDDWPKALLDSGFDRNQPTAWIAEGLLIYLPPQAQDRLFDNITQLSAPGSHLATEYIPDAAAFSDSRSRRVSDGFHRFGFDGQLSDLVYEGERSDVTDYLSAHGWDVTSQTLEEVYAANGFELPGDDMFAAFADARTVSATLRATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT78</accession>
    <name>A0A132PT78_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844608.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20415"/>
    <dbReference type="EnsemblBacteria" id="KWX25548">
        <property type="protein sequence ID" value="KWX25548"/>
        <property type="gene ID" value="AFM11_04730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2827"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="177" mass="19425" checksum="C3280ADCF56187E6" modified="2016-06-08" version="1">MLSTVPTVAPSFVPAVSAPTRLRLPDLLNTTDRAADDVLSGRYDRMLRGLPEDERWYTRLVGNDELDVWLISWVPDRSTELHDHGGSLGALTVVSGTLTETRWDGEGLKRRQLSAGSQAAFPLGWVHDVVRAPGPVSGPTLSVHAYSPPLTAMSYYEVTSRNTLRRSRTELTDAPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTA4</accession>
    <name>A0A132PTA4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Steroid delta-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04830</name>
        <name evidence="3" type="ORF">AWC31_20315</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844643.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20315"/>
    <dbReference type="EnsemblBacteria" id="KWX25566">
        <property type="protein sequence ID" value="KWX25566"/>
        <property type="gene ID" value="AFM11_04830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16401">
        <property type="protein sequence ID" value="ORX16401"/>
        <property type="gene ID" value="AWC31_20315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2847"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="123" mass="13120" checksum="CFCF4B07FFB5C6D1" modified="2016-06-08" version="1">MSHDAAALETFVKRYLDTCAKGVAADIAALYAEDATLEDPVGSGEVHIGRQAIEGFYKNIEAAGGISTELLSFRPGGTEAAFVFAITIGGAMRIEPIEVMTFDDDGQITSMKAYWSPADIKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTL1</accession>
    <name>A0A132PTL1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25678">
        <property type="protein sequence ID" value="KWX25678"/>
        <property type="gene ID" value="AFM11_03760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2629"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="348"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="449" mass="49378" checksum="069B64F948B4DB72" modified="2016-06-08" version="1">MLALYQVFEETGALIAASSHDALTLPDLMEVAMLRERIQRAHGAVDNVIIARMSAEATPQAMGGNSMRDVLVNCLRISRAEAGRRIADAADLGPRRAVNGESLQPKLPRTAAAQSRGEIGTEHVRVIRKFFASLPGWVGADDRAKAEAILARSAPRLSPDELRQATDRMLMTIDPDGKPPSDADRARRRYLYVGKQGPDGMSEVRGLIDPEARAVWDAISAKWAAPGMCNPDDETPCVDGEPDKEAVERDSRTQIQRNHDAFKAVGRAMLASGELGQHNGLPCTVVVTTTLAEIESGEGWAVTGGGSMLPMSDVIRLAGHAHHYLCVYESHTEVPMYLGRTKRVASPGQRIVLYARDRGCTRPGCTAPPYWCEVHHRDKDWIAGGHTNVDELTLACKPDHRLLTNKGWKTRIRKDGRTEWIPPPQLDTGQARVNEYHHPERYFDGPECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTL8</accession>
    <name>A0A132PTL8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844871.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21455"/>
    <dbReference type="EnsemblBacteria" id="KWX25676">
        <property type="protein sequence ID" value="KWX25676"/>
        <property type="gene ID" value="AFM11_03700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2616"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="105"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="456" mass="49837" checksum="67D168A430635B1A" modified="2016-06-08" version="1">MVRTHTVVAGETLSALALRFYGEAELYPLIATASGIPNPDVVNVGQPLVFPDFTRYTVGAGDTLSAVAQRFYGDAALARFIAGASGTNTSASLAAGQRLIIPDIARHRVVAGDTLAALAARFYGNASFHPLLATVNGIANPDVINVGQVLVVFTGRSDGFGLRIVDRNENDPLLWYYRFQTAAVGWNPGVNVLLPDDYRTSGRTYPVLYLFHGGGPDADFRSFDFMGIRDWTAGKPIIVVMPDGGHAGWYSNPVTSFVGPRNWETFHIAQLLPWIDANFRTFAEYDGRAVCGFSMGGFGALKYAAKYFGHFASVSSHSGPASLRRDFGLVVHWANITSAVLDLAGGTVYGAPFWDQARVSADNPVERIESYRNKRIFLLAGTSPDPLNWFDSVNETQVLAGQREFRERLGQAGIPHEWHEVPGGHIFRPDMFIRDLDGIIARLRHAEIARTTDELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTU5</accession>
    <name>A0A132PTU5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diacylglyceryl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844443.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20905"/>
    <dbReference type="EnsemblBacteria" id="KWX25472">
        <property type="protein sequence ID" value="KWX25472"/>
        <property type="gene ID" value="AFM11_04250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2727"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="261" mass="28268" checksum="122BAF4EE28F7EA5" modified="2016-06-08" version="1">MEPVWQVGPATVPVHGLFVALGVFAAMLVFIAEARRRGAVNEQSVVAVAGALVGGAIGMRLSGWAQHLDFSANPSLAQAWQFGSRSILGGLLGAYLGVLVAKRLGGYRGKTGDLFAPAVALGMAIGRIGCHLTEAPGRPTTLPWGIHAPATTPECPGCVAGQAMHPSFLYEIAFQLTAFAILLWLRNRISHPGELFVIYIAGYAAFRFLVEFVRANDTVWLDLTRPQWFLLPSLLIIGIRLWYGHRHGYYRPAARNQEVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTY9</accession>
    <name>A0A132PTY9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842266.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33605"/>
    <dbReference type="EnsemblBacteria" id="KWX25809">
        <property type="protein sequence ID" value="KWX25809"/>
        <property type="gene ID" value="AFM11_00490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.100"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="298" mass="32524" checksum="494CF404B62962DA" modified="2016-06-08" version="1">MARTDGDTWDLASSVGSTATGVAASRALATKQPDPLINDPYADALVNAVGLEHFIKLANGELCVEGDQMLDRQRMCEQIAVRTRFFDDFFSAAGAAGIRQAVILASGLDTRAYRLNWSPGTVVFEVDQPEVIEFKSQTLAKLGAEPGAERRAVAIDLRDDWPAALRAAGFDPSAPTAWIAEGLLIYLPPDAQDRLFDNITALSAPGSRLATEHMDMNMLSEEWTKKVSEWSKRVGSEVDLKDLFYSGERHTARDYLSSHGWQVTVESTRDAYAGNGFELPEDLAELAGDSGYLSAQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU31</accession>
    <name>A0A132PU31_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842391.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25851">
        <property type="protein sequence ID" value="KWX25851"/>
        <property type="gene ID" value="AFM11_00725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.149"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="259" mass="26966" checksum="F00BDBCFE479AEDA" modified="2016-06-08" version="1">MTQLDLTGRTAIITGASRGIGLAAAQAIAAAGGNVVLTSRRQEAADEAAAEVDGNAVGVAAHAVDEKAAQRCVDLTLERFGSIDILVNNVGTNPSYGPVIDQDHARFTKTFDVNLWAPILWTSLATRAWMGEHGGAVVNTASIGGMGFEANLGLYNASKAALIHLTKQLALELSPKVRVNGVAPGVVRTRLAEALWKEHEDQLNSATPLARIGEPDDVGSAIAFLVSDAAGWVTGETFVIDGGQRLGDARLFRSGAGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU78</accession>
    <name>A0A132PU78_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842308.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33680"/>
    <dbReference type="EnsemblBacteria" id="KWX25824">
        <property type="protein sequence ID" value="KWX25824"/>
        <property type="gene ID" value="AFM11_00565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.116"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="306"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="402" mass="43579" checksum="81639EC85572B0C7" modified="2016-06-08" version="1">MTTKRDLASIDLTADRELALLRELIQAASSGPGVEPLAAAAARMITAATATDVCFVHVLDDSDRSLTLTGATPPFDREVGKIRLPLGQGISGWVASHREPVVISHDKEADPRYLPFESLRGRDFTSMVSVPMETGPGGLVGVLNVHTVHRREFTARDVELLVVIGRLIAGALHQARLHRQLVARERAHENFVEQVIEAQELERRRLAADIHDGISQRLVTLSYRLDAAARAVGEPTTVAEQLDKARELVDLTLQEARAAISGLRPPVLDDLGLSGGLASLARSIPRVELEVDLAETRVPDHIELALYRIAQECLQNVVKHAEATRAKLTFAVEDGVARLEIVDDGKGFDTFEHPLGSDETSGYGLLSMAERAEIVGGRLNIRSRPGTGTTVTATIPLPSVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUM6</accession>
    <name>A0A132PUM6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842803.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25974">
        <property type="protein sequence ID" value="KWX25974"/>
        <property type="gene ID" value="AFM11_01495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.306"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="267" mass="29759" checksum="D055EA22ACB690E6" modified="2016-06-08" version="1">MTNTMTVNGVQIAFVDEGLEPGPVIVPLTGWAHDHRAFDRLVPHLIPKHRVVRVCWRGHGPDRTPVGDFGVAEQVADTIALLDALEIETFVPVAHAHGGWAALDIAEQLGPDRVPAVMILDLIMTPAPPEFVAGLHAIQQRETWLAGRDGLVQSWLDGSDNPAVRYHMQHEAGGFGFDMWSRACRVIEDAYNTWGSPMGRMEKLGQPRPIRHVFSHPKVPEYDGLHDEFRSRNPWFSYTRLPGETHFPGIELPEHVAAELTDLLSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUQ2</accession>
    <name>A0A132PUQ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_02175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843110.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34955"/>
    <dbReference type="EnsemblBacteria" id="KWX26071">
        <property type="protein sequence ID" value="KWX26071"/>
        <property type="gene ID" value="AFM11_02175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.445"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="41"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="204"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="306"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX26071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="542" mass="57602" checksum="35F04EDFD893E1D2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUT7</accession>
    <name>A0A132PUT7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_02315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843200.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35095"/>
    <dbReference type="EnsemblBacteria" id="KWX26096">
        <property type="protein sequence ID" value="KWX26096"/>
        <property type="gene ID" value="AFM11_02315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.474"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="254"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1501" mass="161247" checksum="94EFAE463784E573" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV31</accession>
    <name>A0A132PV31_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843575.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26219">
        <property type="protein sequence ID" value="KWX26219"/>
        <property type="gene ID" value="AFM11_00730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.150"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="37518" checksum="C9AF48DFACEC774A" modified="2016-06-08" version="1">MTEVCDIAGVDTGAVSDWFTALGIDFAAPLRFQRIGLGQSNLTYRVTDADDRAWVLRRPPLGHLLASAHDVVREARIIAALARTDVPVPRMLGVTTEYADVPLVLMEFVDGLVVDTMDVAEALTPQQRRQIAMSLPRTLAKIHAVDLAEVGLADLASHKPYAQRQLKRWAGQWELSKTRELPALDDLTRRLAAAAPEQREISLVHGDFHLRNLITSRVSGEVIATLDWELSTLGDPLADMGSLLTYWPEPGEATSGDFAPSTLDGFPDRAEMARLYLEATGRDSAGLQYWHVLGLWKLAIIAEGVMRRAMEEPQNKAAAGTPTVARIDALVDKARQIADSAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV49</accession>
    <name>A0A132PV49_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33930"/>
    <dbReference type="EnsemblBacteria" id="KWX26221">
        <property type="protein sequence ID" value="KWX26221"/>
        <property type="gene ID" value="AFM11_00895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.185"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023840">
        <property type="entry name" value="T7SS_Rv3446c"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03931">
        <property type="entry name" value="T7SS_Rv3446c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="372" mass="39418" checksum="A1DAAE0D3350DBB2" modified="2016-06-08" version="1">MEIGPVTVRGPGTVSPEYAMAAVECIDDTTVLVGEQPMAVDDLWVEVIAAAAGAEVDALTLVCPTWWTADRIARIQSAVGGRAENRVLQRVHKLTADRADTSWAVVEIAVELVLVSRGDAEPVALVRWGEDDVLAQSVVDAVDGAGEVIVDAPAEVPGARALGRLVAGRIGDRGACVTMADPALLRREIATAHTEPELRRTRPSRRGSAVCAAVIALCAALAVSLPDRPQPAEPMAVLVEGRVGVQVPVGWTVQRITSGPGSARVEVVSNTDPAVAVHLTQSPVSDTPAAETLRRALDEQPAGVFVDFNPTDRIAERQVITYREVRAERHVQWAVLVDGPLRIAIGCQNPPGRDDLVRAACDMAVRSAHAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAU3</accession>
    <name>A0A132PAU3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000051">
        <property type="protein sequence ID" value="KWX19443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003887006.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19443">
        <property type="protein sequence ID" value="KWX19443"/>
        <property type="gene ID" value="AFM11_35815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6242"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="156" mass="16560" checksum="766CA57972E07BED" modified="2016-06-08" version="1">MGCGPDNPHGLQLVVYRCGEQVYADATFDERHIGAPGLAHGGAVAAACDDVLGFTLWIAGTPAVTRSLTVEYLLPVPLHQPHRITAHITERNGRALHVRATGTGTDGVTRFTASAVFVVVSTEHFAAHGDLAAFDSLLERFTRSSRAHADPHDPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAU8</accession>
    <name>A0A132PAU8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_35805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000050">
        <property type="protein sequence ID" value="KWX19449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19449">
        <property type="protein sequence ID" value="KWX19449"/>
        <property type="gene ID" value="AFM11_35805"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1048"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2101"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1028"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1083"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="2136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="3237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX19449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="3237" mass="348035" checksum="5EDDCBB496557B75" modified="2016-06-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB03</accession>
    <name>A0A132PB03_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoadipate enol-lactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000044">
        <property type="protein sequence ID" value="KWX19515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040849.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19515">
        <property type="protein sequence ID" value="KWX19515"/>
        <property type="gene ID" value="AFM11_35505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5835"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012788">
        <property type="entry name" value="Decarb_PcaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02425">
        <property type="entry name" value="decarb_PcaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="297"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="393" mass="41134" checksum="344CDA545FAAE95C" modified="2016-06-08" version="1">MTIPALATIDFGGPDGAPVLVLGPSLGTSAATLWSAAAGWLSAHARVVGWDLPGHGRGGPGEPFTIAELAVAVLALADDMHAETFHYAGDSLGGCVGLQLMLDAPQRVDSATLLGTGALIGTPAGWLERAATVRAEGVETLLSGAAQRWFAPGFVDRQPGVGAALLDTLSHTDPESYAQACEALAAFDVSDRLREIVTPVLAVAGSADVPTPPESLRRIASGVQDGDLVVLDGVGHLAPAEAPDRVAGLIAEQVGIPQPATRTVEDVCRAGMAIRRQVLGDGHVDRAIAGTTDMTADFQHLITQYAWGTIWTRPGLDLRSRSMITLTALVARGHREELAMHLRAARRNGLSNDEIKELLMQTAIYCGVPDANSAFRIAAEVLPEFDEDERASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB51</accession>
    <name>A0A132PB51_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_35205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="146324">
        <property type="entry name" value="M.MwoCDC01ORF35205P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19540">
        <property type="protein sequence ID" value="KWX19540"/>
        <property type="gene ID" value="AFM11_35205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5771"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX19540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="303" mass="33775" checksum="5D9593A7A9389CD6" modified="2016-06-08" version="1">MRRRGYDALMAAKGQLHRMLTDGVVHGDAAKLLPKLPPGSVDLFFTSPPYADARAYSRIHPDHYVEWFLPLAEQMLTATAETGSLVINIKNRVANRGELRGQRHPYVYQLVLALQQMGWRWIETYIWAKPNAVPGRFGPRTKDAFEYVYHFARGERPYFDLDAVRVPYKADAAEIARRALDSNGRRTTAAGFGRDRTKTYLHGGADPGNVVSVPQTYNQHRGVAHTAAMPEGLAEFFIRCASPKGGLVVDPFAGSGTTVVVARRYDRQAIGFELHEDYAKEARKRIVADKADDPAVDLHAVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB80</accession>
    <name>A0A132PB80_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859645.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19566">
        <property type="protein sequence ID" value="KWX19566"/>
        <property type="gene ID" value="AFM11_35085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5745"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="249" mass="26939" checksum="EDEAE503065F3235" modified="2016-06-08" version="1">MLSSILGSSPDAELKRARLFFWAVILLSSATSIAGNGAHTWVAADVTIPRELATAVAIAPPVFLILCIEGIATLIRTLYKATWLFWVNVAMTTVLATFAFILSFEALRDLAIGAGIPRELAFMWPVIVDVATAIATCAVVYLSRYRGNNLPTVEDDTENNAADGDAQDEIPDDSSGLTAITLREEHAQRAATIRSRRKLRKSTDDVQRVLALSDSGKTVDDIATITQMHPSTVRRILGTDRGTVALQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBD2</accession>
    <name>A0A132PBD2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvP</name>
        <name evidence="9" type="ORF">AFM11_34865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859505.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11005"/>
    <dbReference type="EnsemblBacteria" id="KWX19639">
        <property type="protein sequence ID" value="KWX19639"/>
        <property type="gene ID" value="AFM11_34865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5322"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX19639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="948" mass="101405" checksum="132650A9F2D9B9C3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBD4</accession>
    <name>A0A132PBD4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859482.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10945"/>
    <dbReference type="EnsemblBacteria" id="KWX19628">
        <property type="protein sequence ID" value="KWX19628"/>
        <property type="gene ID" value="AFM11_34800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5309"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="160" mass="17259" checksum="D14380FE809511E5" modified="2016-06-08" version="1">MAISDDDLSHLRRCVELAAEALEDGDEPFGSILVDESGATLFEDRNRVKDGDATQHPEFAIARWAVNRLDPPQRARATVYTSGEHCPMCAAAHAWVGLGRIVYATSSEQLTGWLLEWGAPPARVAGLPITTVAPGAQVEGPVDEFAEPMKALYAAKFQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBU8</accession>
    <name>A0A132PBU8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">thrS</name>
        <name evidence="13" type="ORF">AFM11_35715</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000047">
        <property type="protein sequence ID" value="KWX19462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859918.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12675"/>
    <dbReference type="EnsemblBacteria" id="KWX19462">
        <property type="protein sequence ID" value="KWX19462"/>
        <property type="gene ID" value="AFM11_35715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5879"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="248"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX19462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="684" mass="76556" checksum="E5EB1E165EBB69C3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC66</accession>
    <name>A0A132PC66_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858876.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07975"/>
    <dbReference type="EnsemblBacteria" id="KWX19827">
        <property type="protein sequence ID" value="KWX19827"/>
        <property type="gene ID" value="AFM11_33780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5093"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="331" mass="33740" checksum="C281042038671C75" modified="2016-06-08" version="1">MAALVLLFTAGCSSNPADTPPPTIEPAQAAVSPPVTATPDGQVRPVTGHAQAAVFDAATSTLAVLGPGPDGQSSLTLLAGTAPPRTVLLESKATALSGDGRGGLLLPTRGGYFRVDLARAAAKPERVGIDGQQDVDFTAIAVRADGKLVLGSADGAVYTLDGPTTVGARLKIFARVDSLVTQGNTAVVLDRGQTSVTTVDADGTEADHALRAGEGATTMTTDPQGRILVADTRGDGLLVFGTDPLILRQRYPVRGAPYGLAGSPGLAWVSETATNTVIGYDLDTGIPVEKVRYRTVQQPNSLAYDDKADTLYVVSGSGAGVQVIANAAVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCK9</accession>
    <name>A0A132PCK9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32385</name>
        <name evidence="3" type="ORF">AWC31_19510</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX17022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858061.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19510"/>
    <dbReference type="EnsemblBacteria" id="KWX20063">
        <property type="protein sequence ID" value="KWX20063"/>
        <property type="gene ID" value="AFM11_32385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17022">
        <property type="protein sequence ID" value="ORX17022"/>
        <property type="gene ID" value="AWC31_19510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4805"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="103" mass="10896" checksum="7AB0E1438F80F272" modified="2016-06-08" version="1">MTAEATPAGETGGKVTIVFDREQASVPRRQGETLLESARRAGMTPPFSCEAGNCGTCMAKLLEGTATMRVNDALDDDEVADGYVLTCQAVPDCDSITVSYDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCV6</accession>
    <name>A0A132PCV6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_31965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857819.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31930"/>
    <dbReference type="EnsemblBacteria" id="KWX20160">
        <property type="protein sequence ID" value="KWX20160"/>
        <property type="gene ID" value="AFM11_31965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4719"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="209" mass="23010" checksum="848E5311DFD9E18D" modified="2016-06-08" version="1">MESSSSQRAYQLTKDQILSGEVRGGQLLSEVEVAGQLGISRTPVHEAFLRLAAEDLLDLLPRRGAVVIPVPSREATDLLEMRLALETAAVRRLCRSPETVDQLFTELTDLVAEQRRVAGDTQQFAAADDAFHRRIVEVAGNSIAQRFYGSLSDRQRRMMADAARSDSARLTELVNEHGRLAEAIGRRDVAAFEAALLAHLEATYRVVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCV8</accession>
    <name>A0A132PCV8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C56</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857816.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31935"/>
    <dbReference type="EnsemblBacteria" id="KWX20159">
        <property type="protein sequence ID" value="KWX20159"/>
        <property type="gene ID" value="AFM11_31960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4718"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="8"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="186" mass="19818" checksum="6B9CE57FA66810C8" modified="2016-06-08" version="1">MSQVLDGKKIAILATDGVERRELTEPRDAVRNAGGTTELLSLKSDAIDARDHDLQPAGTYDVDRPVAKAKVDEFDGLVIPGGTVNADKLRSDSDAVSFVRDFVESGKPVGVICHGPWTLVEAGVAKGRTLTSYPSLRTDLRNAGANVVDQELVVDGNLMTSRSPDDLPAFCAAIVEAFAKERAPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDF0</accession>
    <name>A0A132PDF0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homocitrate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_30915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857190.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26635"/>
    <dbReference type="EnsemblBacteria" id="KWX20363">
        <property type="protein sequence ID" value="KWX20363"/>
        <property type="gene ID" value="AFM11_30915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4085"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LeuA_dimer" evidence="3">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="158" mass="16551" checksum="F86360FEE6D852D9" modified="2016-06-08" version="1">MFPSSTPQAPSFAANFTAPLPRDLRSLGDTTCWDAFLAEFAPSAGPLRLGHWACTDNADRLGPQARRYQATLAIGDTISTSTAAASGPVAALTEMLYQRGIAVETTSFHQLPTGGQTATFIKGSDGVHTQWAMGLADDPEQSALRAVIACANRLLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDI9</accession>
    <name>A0A132PDI9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3298 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857292.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26830"/>
    <dbReference type="EnsemblBacteria" id="KWX20398">
        <property type="protein sequence ID" value="KWX20398"/>
        <property type="gene ID" value="AFM11_31120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4128"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453216" description="DUF3298 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="2">
        <location>
            <begin position="150"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="24893" checksum="AC7029D049FB1DA2" modified="2016-06-08" version="1">MRIPPVLALIAAGLLGGWGGLPTAAAQTACAELGGTVDQDQVCQVHTTNAAYTLDYTFPEGYPDQQAITGYLIQTRDGFVNVSDMPGSRDQPYVLDARGTAYTSGAPGLPPRTQSLVLEVYQNVGGAHPQTWYKAFNYDLLTRAPITFDRLFKPGTRPLDVIFPIVQRELQKQSGVEQAIPQSVGLDPTHYQNFAITDDSVIFFFGQGELLSEAAGATQASVPRSALAAMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDK8</accession>
    <name>A0A132PDK8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857986.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20042">
        <property type="protein sequence ID" value="KWX20042"/>
        <property type="gene ID" value="AFM11_32225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4773"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="233" mass="25667" checksum="15B5D705039272F3" modified="2016-06-08" version="1">MTAPGTPNVFSSKADVAYAELRRLILNGGLPAGSRLAQYELAEQWRMSITPVREAIRRLSGEGLIEIDNHKDARVSAIGADEARQLFEVRLALEPAAVALAAERRTDDDIAVMKSALSQLVPVTREWGEEGLCAHSAFHRTLYVASHNDVMIKTLDDLWAKSDRYRRLGLMLPAGDEPRIIDFNQHHQMLELVIDRNAAEAQALARLHIENSLTASAIDALEDDLPAPRSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE09</accession>
    <name>A0A132PE09_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel protein MscS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_29620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856470.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24960"/>
    <dbReference type="EnsemblBacteria" id="KWX20563">
        <property type="protein sequence ID" value="KWX20563"/>
        <property type="gene ID" value="AFM11_29620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3815"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="314" mass="34487" checksum="817D92991671440A" modified="2016-06-08" version="1">MHVYNLAFEWTDTNRHWLIEVPVRIVAYIVIALIARYVLHRLIDRATTGRPHKAGAAPDQEKTKPPLLRHLRDRTPKAAGGQRIAERRQQRAQTIGSVLKSTVSIVLLVWVVLTVLNVLGVNIAPFIASAGVVGLAIGFGAQNLVRDFVTGVFMLLEDQYGVGDNVDLGEAVGEVQSVGLRITTVRDIDGTLWYVRNGEIARVGNMSQEYAVARIEVPVALTADIDRAEEVAVEAAEAAIADPSLANKVLGKPEMLGVQELSPDLLKLRMTVKTKPNAQWAVQRKLRREVLRSYDEHGIDLPYPSGRFQAVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE25</accession>
    <name>A0A132PE25_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">prfB</name>
        <name evidence="7" type="ORF">AFM11_31255</name>
        <name evidence="8" type="ORF">AWC31_25405</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857417.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25405"/>
    <dbReference type="EnsemblBacteria" id="KWX20222">
        <property type="protein sequence ID" value="KWX20222"/>
        <property type="gene ID" value="AFM11_31255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14532">
        <property type="protein sequence ID" value="ORX14532"/>
        <property type="gene ID" value="AWC31_25405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4156"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX14532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="368" mass="41233" checksum="965F647FE4CF0EFB" modified="2016-06-08" version="1">MDPDRQADIAALDTTLTTVERVLDVDGLRGRIERLEAEASDPNLWDDQTRAQKVTSELSHAQGELRRVEDLRSRLDDLPVLYELASEEGGADELAEADAERKKLREDIEAMEVRTLLSGEYDEREAVVTIRSGAGGVDAADWAEMLMRMYIRWAEQHKYPVEVFDTSYAEEAGIKSATFAVHAPFAYGTLSVEQGTHRLVRISPFDNQSRRQTSFADVEVLPVVETTDHIDIPETDVRVDVYRSSGPGGQSVNTTDSAVRLTHIPTGIVVTCQNEKSQLQNKVSAMRVLQAKLLERKRLEERAELDALKGDGGSSWGNQMRSYVLHPYQMVKDLRTEFEVGNPAAVLDGDIDGFLEAGIRWRNRKDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE39</accession>
    <name>A0A132PE39_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_29880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856600.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25220"/>
    <dbReference type="EnsemblBacteria" id="KWX20606">
        <property type="protein sequence ID" value="KWX20606"/>
        <property type="gene ID" value="AFM11_29880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3868"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="35686" checksum="05BF6C23549E31BA" modified="2016-06-08" version="1">MRAVVYPEVGVVPAVVDVADPECADDGVIVEVAATGVCRSDWHAWRGHDPVELPIIPGHEFAGVIAAVGADVSGWQVGDRVTTPFVLGCGRCEFCLAGDAQVCPDQLQPGFTLSGTFAQQVAVPRAQFNLVRLPDTVSFVAAASLGCRFATSFRAVVTHGRVQPGQWVAVHGCGGVGLSAVMIAKAFKAKVIAIDVSVEALAIAGRLGADELVNDNETPDPATEIVRRTGGVHIGIDAVGHPALAAASVSSLRRRGRHIQVGLLLGAAAQTAFPMDRVIAQELVILGSHGMPAVDYPAMLELLASGALDPEQLVTRRIGLDGAGAALADMDNPVGHGMTIIEPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-02-10" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEC3</accession>
    <name>A0A132PEC3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20675">
        <property type="protein sequence ID" value="KWX20675"/>
        <property type="gene ID" value="AFM11_29040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3690"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="142" mass="15869" checksum="6413E05194BE4F0D" modified="2016-06-08" version="1">MDRSAFIPEFFSHVDAKEFNWVKAQLADDCLIADPGMCARGPQAVVDWMSSFMRAFPDMQHRPFQILADDDQAAFLIEITGNHTGSLALSDGNVLPPTGRALKLTISEFWKFTEGKVSEYRVIYDRIEFLAQIGIDAVPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEL8</accession>
    <name>A0A132PEL8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856734.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20432">
        <property type="protein sequence ID" value="KWX20432"/>
        <property type="gene ID" value="AFM11_30045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3902"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="391" mass="43698" checksum="AFA9EDE0253F9EDB" modified="2016-06-08" version="1">MEDEIARRPMVVMSYGMGVDSTAILLRWLTDPSSRDFDLGDLVVLTAHTGDEFDETMRDVEEVVLAEMRRHCVRFVQVGRSQRATTASGEGVVVLDDSTKPDRLYASSGYKLSDEMLSAGTIPQIGGARICSIHAKANCLEPVIASITAGRRYRHVLGFEAGEKARAAKDALFNTEQRVGWYPLIDWDWDRNRCREFVAHVTGRTWTKSACSYCVFAMTNRSGQQAVIERYRREPAAAARALLLETVARSLNERQTLIAGTSVAALIARADLAEAQERFEAMLDNCEHAVYEVRRLTRKSSKRPDGRGLTARSVRSTVRGTRPQMHDALRGFPGRRQVGADGIVRHVVRERSCGLPAIEHFYVVCPAVVDDKERAGFDTWWQEATTDAVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEN1</accession>
    <name>A0A132PEN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856189.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20796">
        <property type="protein sequence ID" value="KWX20796"/>
        <property type="gene ID" value="AFM11_28610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3602"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="30"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="303" mass="34838" checksum="497CCF4301A8ECE7" modified="2016-06-08" version="1">MTDKKIQISVGIDVDSCAGWLGSYGGQDSPNDMQRGVFAGEVGVPRMLKLLERRNIVSTWFWPGHSIETFPKQAEMCVDAGHEIGAHGYSHENPRSLSQEQERDVMAKSVKLVEQLTGARPKGYVAPWWEMSEHTASILKEYDFSYDHSQNYNDFVPFYARVGDEWTPIDTLKPAAHWMKPLKHGHEIDLVEFCGNWYVDDLPPMMFIKSHPNSHGFVNPRDIEQLWNDQFDWVYRELDYAVIPMTLHPDVSGRPQVLLMLERLLDRWASFDGVEFVTMAKAADEFRARYPFGQPTRPDCVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEV6</accession>
    <name>A0A132PEV6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_27660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855650.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10195"/>
    <dbReference type="EnsemblBacteria" id="KWX20878">
        <property type="protein sequence ID" value="KWX20878"/>
        <property type="gene ID" value="AFM11_27660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3406"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="363" mass="39378" checksum="1B862FFE6206E54A" modified="2016-06-08" version="1">MAEHDAGDEPTRVDEQRGAEQTQEKAQAPHPDDPRKPDSPDDLTKASWWYVLRKTAREFSADQCTDLAAALTYYAVLSLFPALLVMVSLLGVFGQGQRTTDAMLEAAGDVVPASALDLLRQPIEQVVESPSAGVTLLVGVLGALWSASGYVGAFGRAMNRIYEVGEGRPAWKLRPQQLLLTLVALILAAAVAFMLAVSGPVAETLGNIIGLGSAAQTAWAIAKWPVILVFVMLAVAILYYATPNVKQPKFRWLSIGSAVAIVVWVIASVGFGFYVSNFGSYNKTYGALAGVIVFLLWLWLTNLALLFGAELDAELERGRQLQAGIPAERDLQLPPKDTRVIEKNEAAEEKYVKLGRRLRRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF03</accession>
    <name>A0A132PF03_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856163.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20787">
        <property type="protein sequence ID" value="KWX20787"/>
        <property type="gene ID" value="AFM11_28540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3586"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006160">
        <property type="entry name" value="SCFA_transpt_AtoE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41983">
        <property type="entry name" value="PTHR41983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02667">
        <property type="entry name" value="SCFA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="475" mass="51288" checksum="C9A110FE932EEB2E" modified="2016-06-08" version="1">MSQATQQRETFLQRIAGGLSRWSLRWVPDAWVVVVLLTFVVFLLAFFLGPGELGLGKAGDLIAGWGDGFWELLEFGMQMAMIMLTGFVVATSPPFRRVLTWVADRPKGPKSAVAVMAATSMILVLVNWGLGLIGSAVLVRYMAARQPKVDYRLLVAAAYLGMAGTWHAGLSASAPLLVATPGNFAEEFYGRLIPVSETIFSPFNVVLTLVVIVLWVVMTPLLHPREDQTVPPPEGIAEADDVDEESVRAEGPGAATAPARLTPAMRIENSHWVNMVIGGVGLIYLAIYFTGLEGGILSGITLNTVNFIFLFIGILLHGTPASLLKQAERGGAFAWGIIIQFPFYAGILGIITATGFSERIAGWFTAIANEHTFPVMTYWYSGLVNLFVPSGGSKFAIEAPYIAEAAQNLGVSPELTVIAYAWGDMATDAIQPFWALPLLAIARLGFRDVMGFLLTLFIAYAVVVSGAFLVAPFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFB3</accession>
    <name>A0A132PFB3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_28175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX21003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856031.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10725"/>
    <dbReference type="EnsemblBacteria" id="KWX21003">
        <property type="protein sequence ID" value="KWX21003"/>
        <property type="gene ID" value="AFM11_28175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3510"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453045" evidence="4">
        <location>
            <begin position="40"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="136"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="259" mass="26875" checksum="591A8A14E88AE7B5" modified="2016-06-08" version="1">MLSTPSPTTRTVRVSVLKVFAAVGVAVLALASSVNVAQAGVSTGATAAKIEPAAGDVVGVAHPVTVTFTAPVTDRQAAEKSLRVSSTSTPTGEFTWLSDDVMQWTPDQFWPAHSTISVAAGGAKTSFETGAAVVGVADIDAHTFTVSIDDEVVREMPASMGKPKFPTPTGTFTALSKEPVVVMDSRTIGIPLSDPEGYKLTVNDAVRVTWGGVYVHGAPWSVGSQGYANVSHGCINLSPDNAAWYFETVSVGDPIIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFE7</accession>
    <name>A0A132PFE7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multidrug MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_27210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855345.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07140"/>
    <dbReference type="EnsemblBacteria" id="KWX21066">
        <property type="protein sequence ID" value="KWX21066"/>
        <property type="gene ID" value="AFM11_27210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3317"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="247"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="31365" checksum="199BA7F467F8F94D" modified="2016-06-08" version="1">MAVVAIAGSSGLIGSALASALRASDHRVLRIVRRAPSNGDELFWNPDTGEFDAGALHGVDVVVNLCGVNVGEKRWSGAFKQSLRDSRIGPTEVLAGAVADAGVPVLVNASAVGFYGDTRDHITDETAPAGQGFLARLCQDWEAATAPATAAGSRVVLLRTGLVLAQAGGMLSRLKPLFSFGLGARLGNGRQYLPWISLEDEIRAVLFTMWTDAVSGPVNLTGPAPVTNAEFTAALGRALNRPTPMIVPGFALRAVLGEFADEGLLAGQRAIPAVLERSGFVFHHNTVREALAHATAPKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFL9</accession>
    <name>A0A132PFL9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855526.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07475"/>
    <dbReference type="EnsemblBacteria" id="KWX21125">
        <property type="protein sequence ID" value="KWX21125"/>
        <property type="gene ID" value="AFM11_27540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3382"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="222" mass="23965" checksum="297F2331A9EC1C27" modified="2016-06-08" version="1">MSAWSVRRDVARTFQDRREAGQVLAQRLVSYRGDPDVLVLGLARGGVPIAWEVASFLDAPLDVFLVRKLGVPQWQELAMGALASGGGVVINDSLVRRLGISEDQVAEAIRRETVELERRERAYRGDRPAPDLTDRTVILVDDGIATGSSMLAAVRAVRAARRVVVAVPVGPATVCSQLNSEADEVVCASTPMDFESVGQAFADFHQVSDDEVRRLLAAPTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFQ5</accession>
    <name>A0A132PFQ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_26255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854831.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23345"/>
    <dbReference type="EnsemblBacteria" id="KWX21165">
        <property type="protein sequence ID" value="KWX21165"/>
        <property type="gene ID" value="AFM11_26255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3118"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="228"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="368" mass="38757" checksum="AF6D9BDBDC278EEB" modified="2016-06-08" version="1">MDFQLTDEQTLLADTTRDLLSASYDAETRNKVVDSDPGYNPQVWSQLADIGVLGLGFDEDSGGQIEIMLVLNEIGRQLAPEPLLHGAIGPGALIAEQGSADQRALLDEVAAGQRLLAFAHAEPGPRGAAIATTAARDGDSWTLTGTKNPVLAGDSANTLIVSAALPDGGVGLFLVDASGSGVTRTGYRTFDGRRGAQIELAGAPAEPLGEAVDATDAITRALVRLSSALCAEAVGAMDEALRLTTDYLKQRKQFGVTLSKFQTLTQRAADMYMSLELARSMADYAAMSIADGQFDPVIAARAKLQIGRSGRHIAQESIQLHGGIGITAEYPVGHYAARLTAIEHTLGSSQDQLHTLIGQLADYEIVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFX5</accession>
    <name>A0A132PFX5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Prephenate dehydratase</fullName>
            <shortName evidence="11">PDT</shortName>
            <ecNumber evidence="4 11">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pheA</name>
        <name evidence="14" type="ORF">AFM11_26640</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="4 11"/>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855026.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22695"/>
    <dbReference type="EnsemblBacteria" id="KWX21231">
        <property type="protein sequence ID" value="KWX21231"/>
        <property type="gene ID" value="AFM11_26640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3199"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="12">
        <location>
            <begin position="3"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="13">
        <location>
            <begin position="204"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="10">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX21231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="32363" checksum="7D143CDDA78FE657" modified="2016-06-08" version="1">MQRIAYLGPEGTFTEAALLQMVAQNMVPGSQGGDGGFTPVRTDSTPGALSAVRDGRADYACVPIENSIEGSVLPTMDSLAAGSPLQIYAELTLDVAFTIVVRPGHTGPVRTVAAFPVAAAQVRNWLAANLPDAAVVPANSNAAAAHDVAEGRADAGVSTRLAAERCGLDILAADVVDEVNARTRFVLAGPPGPPPPATGADRTSVVLRLDNTPGALVAAMTELSIRDIDLTRIESRPTRTELGTYVFFLDCVGHIDDDSVAEALKALHRRCSDVRYLGSWPTGSAAGAPPPRFDEAARWLARLRDGSGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFX6</accession>
    <name>A0A132PFX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855070.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22610"/>
    <dbReference type="EnsemblBacteria" id="KWX21246">
        <property type="protein sequence ID" value="KWX21246"/>
        <property type="gene ID" value="AFM11_26725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3216"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acidPPc" evidence="1">
        <location>
            <begin position="62"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="185" mass="18814" checksum="B35DED8A96884B04" modified="2016-06-08" version="1">MSDAPRGEDAVLVAVQSALAGRPGVLAGARALSHFGEHSAGWVALAAAGAVAQPARRKSWIAVGAGAFVAHAAAVLIKRVVRRERPHHPDIAVNVGTPSRLSFPSAHATSTTAAAVLLARTTGLPMPALLVPPMALSRLVLGVHYPTDVLTGVVVGTIVGKTVGKAVGRISDSVGAGPKETDERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH32</accession>
    <name>A0A132PH32_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24285</name>
        <name evidence="6" type="ORF">AWC31_23830</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853678.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23830"/>
    <dbReference type="EnsemblBacteria" id="KWX21645">
        <property type="protein sequence ID" value="KWX21645"/>
        <property type="gene ID" value="AFM11_24285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15591">
        <property type="protein sequence ID" value="ORX15591"/>
        <property type="gene ID" value="AWC31_23830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2216"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX15591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="198" mass="22218" checksum="647BAADE95592A43" modified="2016-06-08" version="1">MAVADGLSARETKRLQTRERLMGAAIAEFKRAGMADADVGAIVAAAGVAHGTFFFHFPTKEHVLLELEQREEERIAKQFAQYLRKPHDLASALRESMRLVINLERRLGDLLFKDFLALHFSQTRPAEDGRDHPIIVGVAREIGLAQERGEVAADVNAMNSAVFFLLGFYALLVTTNDWPTRDALLDDYVRRTLRSLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH40</accession>
    <name>A0A132PH40_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_23900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853478.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24255"/>
    <dbReference type="EnsemblBacteria" id="KWX21584">
        <property type="protein sequence ID" value="KWX21584"/>
        <property type="gene ID" value="AFM11_23900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2138"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="6">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="222"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="342" mass="36901" checksum="69DDAC27AA28CE96" modified="2016-06-08" version="1">MTAAPEASAIEARVGHWYQMDDPYLVGREKVREYARAVQDYHPAHWDVDAAAELGYSGLVAPLTFTSTPAMACNRRMFESIVVGYDTYVQTEEVFEQHRPIVAGDELRIDVELTSVRRIAGRDLITVTNTFTDTAGERVHTLHTTVVGVTAEDVDPTIKTAVQKAMMHDVNILDVGESEAAYEKTVRPEGEIRIADGSNRTPGTPSFDDVKVGDEIAVHHTRLSRGDLVNYAGVAGDANPIHWDEDIAKLAGLPDVIAHGMLTMGLGAGFVSAWSGDPGAVTRYAVRLSAPAIVSAAEGADIEFSGRVKSLDPETRTGVVIVAAKSAGKKIFGLATLDVRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH97</accession>
    <name>A0A132PH97_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26005</name>
        <name evidence="3" type="ORF">AWC31_35895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854625.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35895"/>
    <dbReference type="EnsemblBacteria" id="KWX21372">
        <property type="protein sequence ID" value="KWX21372"/>
        <property type="gene ID" value="AFM11_26005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12004">
        <property type="protein sequence ID" value="ORX12004"/>
        <property type="gene ID" value="AWC31_35895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3066"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX12004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="281" mass="31322" checksum="336B3872C57C864C" modified="2016-06-08" version="1">MRREQLSDFLRTRRARLKPADVGLVDGGRRRTPGLRREEVALLAGVGTSWYTWLEQGREITVSSSVLDAISTALRLTEPERAHLYSLAGTNPPPAAGLRDSPVTPELRHLIDAWSPRPAMLQDRYWNLLAVNDATRQAFGYRDTDRNCLVTFFTNSRYRDMYVHWASAAPGVVAAFRADAALYPDDAAFGEIVNDLSVISPEFEKLWQQHDVGPHLQAVKAVRHPDAGELVFDKTTLAVTDHPGWHLVLYNPRPGTGTADRLDHLMTQSRNGLVSSASSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHP1</accession>
    <name>A0A132PHP1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853398.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28085"/>
    <dbReference type="EnsemblBacteria" id="KWX21878">
        <property type="protein sequence ID" value="KWX21878"/>
        <property type="gene ID" value="AFM11_23360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2027"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="122" mass="12872" checksum="ED77480B98CDF538" modified="2016-06-08" version="1">MTTSEIATVLAWHDALNEKDFDTLISLSSDDIEVGDEAGAAQGHAALREWAEAVGASAVPGRMYVHDGIVVAEQTITTADGETITCASAFRVVRDHVTSVFRHDTLASALAATDLTEQDLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHP8</accession>
    <name>A0A132PHP8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853682.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23815"/>
    <dbReference type="EnsemblBacteria" id="KWX21727">
        <property type="protein sequence ID" value="KWX21727"/>
        <property type="gene ID" value="AFM11_24300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="37173" checksum="B460FD4C0E528E0B" modified="2016-06-08" version="1">MRIGLGINYAGGFKEVAAEVADLERAGLDIVFVPEAYSFDAVSALGYLAASTERVQLASGILQLYTRTPTLTAMTAAGLDYVSDGRFTLGLGASGPQVIEGFHGVPYDAPIARTREVVDICRQVWRRERLQYEGKHYRIPLPADQGTGLGKPLKLINKPVRERIPVLLAALGPKNVELAAEIAEGWQPIFYLPEKANDVWGDALKAGRAKRDPALGDLDVYAGPVLAIGDDVEPLREFVKPHLALYIGGMGAKGKNFYHALATSYGYGAQADRIQELYLAGDKDAAAKAVPDELVRDVSLIGSAGFVKERLAAFRESGVTTLNVVPIGATSADRVKLIEQLRNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHU6</accession>
    <name>A0A132PHU6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852708.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08825"/>
    <dbReference type="EnsemblBacteria" id="KWX21920">
        <property type="protein sequence ID" value="KWX21920"/>
        <property type="gene ID" value="AFM11_22385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1827"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="387" mass="41106" checksum="CE5D2CAF8E48C39D" modified="2016-06-08" version="1">MTNRRPLADIRVVDLSRALAGPYATMMMADAGADVIKVEPPGGDDSRGWLPYVDRNGHRESAYYMSANRNKRSVVLDLKSAGDADRLRWLVSQADVLVENYRPGVLDRLGLGLDGLRELNPRLVTLSITGFGKGGPDGNRPGFDQIVQAEGGLMTLTGRPGGPPQRVGIPIADLLAGLFGAFGVMTALRARERTGRGQHVETSLLAAVVGVHVFHGVGWLAAGVEPVLTGNRHPSIAPYGVFGCADADIVIAVGSEALWRKFAPIVGLDAARPDIATNVDRVSRADELQKEIDTLLADRHADDVLAALDAAGVPAGRIRTVPEVYDWEQVRASMVTTVTHPTLGDLDMPASPLTLSDHREPRCDAPPALGADQDEVFAGYAPAGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHW8</accession>
    <name>A0A132PHW8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved lipoprotein/antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852740.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08715"/>
    <dbReference type="EnsemblBacteria" id="KWX21936">
        <property type="protein sequence ID" value="KWX21936"/>
        <property type="gene ID" value="AFM11_22495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1849"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008691">
        <property type="entry name" value="LpqH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05481">
        <property type="entry name" value="Myco_19_kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453366" evidence="2">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="165" mass="16222" checksum="70FE361D4D73DF69" modified="2016-06-08" version="1">MNRVIAGAMGLLATGAVLVGCSDDKAEPVASGDKPAAAAGASEVSTGGNTQVKVDGKDLAGLDVNSVTCVKQGGKINVASAAIGGQQGLGVVMTDEATPKVESLGLVYDGSALAVSENMGVKVGSAEVKVDGDTYTITGEASGADMKNPMAGMINKPFTITVTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI49</accession>
    <name>A0A132PI49_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Precorrin-3B synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852848.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08390"/>
    <dbReference type="EnsemblBacteria" id="KWX21991">
        <property type="protein sequence ID" value="KWX21991"/>
        <property type="gene ID" value="AFM11_22810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1915"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012798">
        <property type="entry name" value="Cbl_synth_CobG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02435">
        <property type="entry name" value="CobG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="1">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="372" mass="38049" checksum="76EE372CEE39F9D2" modified="2016-06-08" version="1">MARTRDHDACPGALTVHQAADGALVRIRLAGGAITAAQLATLAEVATEYGSPAMELTSRGNIQLRGLTDTAAVAGALTGAGLLPSPTHERVRNIVASPLSGRSGGVADVRGLAAGLDLAIQAEPALAELPGRFWFSLDDGRGDVSGSGADVGAHVLDGDTAALLLAGTDTGVRLAVADVVPTLVDVARRFVTTRGKAWRTTELDDTSELLAGLTASAPAGTRWPPTVKPPVGWIEQHDGRIALGAGLPLGVLGAREAQFLAAIEAPMAITPWRSVLVFDLDEGTADVALRVLAPMGLVFDENSPWLDVSACTGSPGCAKSAADVRSDAAAAAATPSPTHRHFVGCDRACGSPPVGEVLIATEDGYRLRQPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI87</accession>
    <name>A0A132PI87_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_21440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852330.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04255"/>
    <dbReference type="EnsemblBacteria" id="KWX22078">
        <property type="protein sequence ID" value="KWX22078"/>
        <property type="gene ID" value="AFM11_21440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1636"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="29"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="494" mass="52606" checksum="3C788BE079F2F8AF" modified="2016-06-08" version="1">MTQVQSDSGVLAGDERMLIDGELQYTGSGAKFDVIHPATEEVAGQATDGTVADVEKAVGAARRAFDETDWSRDVEFRHHCLMQLHEALEADKERLRRILVTEVGCPVTVTGSQIEDPIGEVKHWAVHGKNFEYVVDTGVHQTQLGPARRKIAYEPVGVVGAITPWNVPFYLNIAETVPALMAGNTVVLKPAQLTPWSGTELGRIVAEHTDIPAGVFNVVVSNANEVGAALSADPRVDMITFTGSTATGRAILAAGAPTVKKTLLELGGKSAHIVLDDADFNSALPIAAMMACVMSGQSCILPSRILLPRSRYDEGIEILKGAMENFPVGDPWTPGIMQGPQISATQREKVLGLIASGLDSGARLVTGGGVPENLPTGYYVAPTLLADVDPDARVAQEEIFGPVLTVTPYDTDDDAVAIANNSIYGLSGEVSSTDLDRAFAIARRIRTGNVTINSRSHFGINSPFGGTKQSGLGRRNGEEGFKEYFESKTIGMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIJ1</accession>
    <name>A0A132PIJ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_22005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852509.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04810"/>
    <dbReference type="EnsemblBacteria" id="KWX22169">
        <property type="protein sequence ID" value="KWX22169"/>
        <property type="gene ID" value="AFM11_22005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1749"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="36186" checksum="699082FD0512AA80" modified="2016-06-08" version="1">MAAVTLQDVAARAGVSQATASRVLNGSSRVPGVGVADRVRAAARELGYVPNAQAQALARASTGLLGLIVHDIADPYFSSIARGVQTAARTARKQVLLASTDRDFDIERESVSTFIAHRADAIVLAGSRQSGDLDRDLEAEFGRYRANGGRVVVIGQPLAFGGAVEPENYFASAELADALIAEGHTQFAVIGGPGSIRTGVDRRNGFVEALGRRGLTPLVEVSGEFTRDGGYSAARRLAGALQISPGAQAEPVCVFAVTDVMAIGAIAAWRELGLSVPDDIGIAGFDDIPTLRDYTPSLTTVVLPLEEIGRRAVELALRTDTDCDDLRERIPGRVILRDSTRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIN2</accession>
    <name>A0A132PIN2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22210">
        <property type="protein sequence ID" value="KWX22210"/>
        <property type="gene ID" value="AFM11_21520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1652"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="143"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="388" mass="41833" checksum="E304DEDF45910E96" modified="2016-06-08" version="1">MGGARHSDVRTDTRTPQPAATPPAVLTSTFPGSARPPSEAEVTVKLQPVAPTTWHQGNGQAPEAGLWNRQAPGNAAPGEHRAIDNLAHVGVKSAVKMHSRRGWRRVLYRTTRINLGLSPDELYELELYARIRRNARESYQIGVFGLKGGVGKTAVTVALGSTLSKVRGDRILAIDADPASGNLGDRVGRQSPATVSDLLSAKDLSRYNDVRAFTSMNESKLEVLSSAEYSSATCAFDDADWIASTGIVSRHYNLVLADCAADMFQPAARGVLETVCGGVIVASASIDGARQAAVTMDWMRQNGHQDLLSRSCVVVNHVAPGKPNVDIGDLVHQFQKHVAPGRVFVLPYDKHIAAGTDIHLDLLRPKFQRRILELAAALSEDFENPLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIT0</accession>
    <name>A0A132PIT0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate starvation protein PhoH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_20700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852047.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22260">
        <property type="protein sequence ID" value="KWX22260"/>
        <property type="gene ID" value="AFM11_20700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1479"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="4">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="348" mass="37312" checksum="EF62C3142EF9CFF3" modified="2016-06-08" version="1">MTPRDTTADSSTTGSGSVRSSITVPPDIIVGLLGSADENLRAIENLLAADIHVRGNEVTFSGEPADVALAERVVAELIAVASSGQSVTPDAVRHSVAILTGTGEESPAEVLTLDILSRRGKTIRPKTLNQKRYVDAIDAHTVVFGIGPAGTGKTYLAMAKAVNALQTKQVNRIILTRPAVEAGERLGFLPGTLSEKIDPYLRPLYDALHDMMDPELIPKLMSAGVIEVAPLAYMRGRTLNDAFIILDEAQNTTAEQMKMFLTRLGFGSKVVVTGDVTQVDLPGGATSGLRAAMQILDGIDDIHFAELTSADVVRHRLVSEIVDAYARHEEPAMLNRAQRRSSSGRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIV3</accession>
    <name>A0A132PIV3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_21710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852409.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04515"/>
    <dbReference type="EnsemblBacteria" id="KWX22117">
        <property type="protein sequence ID" value="KWX22117"/>
        <property type="gene ID" value="AFM11_21710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1690"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="244" mass="26192" checksum="98FA03FD71EA64C6" modified="2016-06-08" version="1">MTAEPDPQPASAETADALLRPVRLGNAFEDTVGRLLETIRLGVLTPGESLPPERELATRLGVSRDTVREAIKSLADAGYLVSRRGRYGGTFLADELPRHTADTPRPTREEIDDALRLREILEVGAARMAAGRTLSAAERDGLWSRLADVRGADPDDYRRLDSRLHLAIAEAAGSPSLVPLVAENRMRLNALLDQIPLLPRNIAHSDEQHEAIVIAILAGDADGAATAMLAHVAGSAALLHGFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ92</accession>
    <name>A0A132PJ92_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851977.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11160"/>
    <dbReference type="EnsemblBacteria" id="KWX22405">
        <property type="protein sequence ID" value="KWX22405"/>
        <property type="gene ID" value="AFM11_19820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1298"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TLP1_add_C" evidence="2">
        <location>
            <begin position="406"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="491" mass="53301" checksum="9551BF4B1A5794CB" modified="2016-06-08" version="1">MSIDPTTPVLVGYGQINQHDDNPDVEPVDLMAAAARAAADPRVLQAVDSVRVVNLLSWHYRDPGLLLAQRIRAEHATTRYTGVGGNVPQTLVNEACLDLMAGRAGVVLIAGAETWRTRSRLRARGARPEWTRQDDSVPEAPGAHEGVPMAGDAELRINLDRPAFVYPMFEQALRIAAGETPDEHRRRIGELWSEFSAVAAGNGHAWSRDRLTAEQISEPGPDNRMISWPYTKLMNSNNMVDQGAVLILTTAEKATYLQIPRDRWVFPYAGTDSHDTYAIGERAELHRSPAIRIAGRRVLELAEVGVDDIDLIDVYSCFPSAVQVAANELGLPLTDPARSLTVTGGLTFAGGPWNNYVSHSIATMAERLVANPGARGLITANGGYLTKHSFGVYGTEPPQHGFRWEDVQSTVDAEPVRKLAVEWSGTGTVESWTTPFNREGLPEKAFLAVRTPDDARTLARITDGSEAAATVAEDIAGAQVRVHPDGTASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJJ0</accession>
    <name>A0A132PJJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-methyladenine DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28540"/>
    <dbReference type="EnsemblBacteria" id="KWX22434">
        <property type="protein sequence ID" value="KWX22434"/>
        <property type="gene ID" value="AFM11_19975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1329"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="307" mass="34364" checksum="468E7E3CE9B29E32" modified="2016-06-08" version="1">MSELAPVATLATRILDESEWTAAEQRHRERVETFLAPHVRRQERGDAHPVWDFLFTYYSLRPRQLRRWHPGFGVVLSGPSARRYLGASGYGRCADGVTVTRDHLAARMETVRFIAALLRATAARPARLNCFGLHEWAMVYRTDAVRHAQVPLRLGSADTDAVVDSMPLRCSHFDAFRFFTEPAAVRNDRQLSREAQLSAEQPGCIHAAMDLYKWAYKLGPLVSSELVIDALELAADARAVDMCASPYDLRRYGFEPIPIETPAGRAEYVRAQQEIAERAAPLRATLANRCELLLISADGEKADVTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKD2</accession>
    <name>A0A132PKD2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17775</name>
        <name evidence="4" type="ORF">AWC31_11895</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851150.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11895"/>
    <dbReference type="EnsemblBacteria" id="KWX22796">
        <property type="protein sequence ID" value="KWX22796"/>
        <property type="gene ID" value="AFM11_17775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18696">
        <property type="protein sequence ID" value="ORX18696"/>
        <property type="gene ID" value="AWC31_11895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.910"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021449">
        <property type="entry name" value="DUF3099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11298">
        <property type="entry name" value="DUF3099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="138" mass="15333" checksum="D0EB34FE51E4079B" modified="2016-06-08" version="1">MKQSHELSFDDDFDGQARPVLITRAAPAYEEQHRQRVRKYLTLMAFRIPALILAAVAYSVWENGLVSLAIILVSVPLPWMAVLIANDRPPRRAEEPRRYAGSKNRIPLFPTAERPALAPGPVVPPQPGTAETRGDVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKQ0</accession>
    <name>A0A132PKQ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11970"/>
    <dbReference type="EnsemblBacteria" id="KWX22921">
        <property type="protein sequence ID" value="KWX22921"/>
        <property type="gene ID" value="AFM11_17900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.935"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="131" mass="14566" checksum="017DF93B6335CF35" modified="2016-06-08" version="1">MPSADETPELRTEFPFVLPRGYVDPAGAVHRHGVMRLATARDELVSQRDDRVRESPNYLAVVLISRVVTRIGEIEDVHGGVIENLFASDLAFLQDLYRRINQDGHTHARVTCPHCSNDFAVDVAGSRLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLD7</accession>
    <name>A0A132PLD7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PaaR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17875</name>
        <name evidence="2" type="ORF">AWC31_11945</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851183.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11945"/>
    <dbReference type="EnsemblBacteria" id="KWX22812">
        <property type="protein sequence ID" value="KWX22812"/>
        <property type="gene ID" value="AFM11_17875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18883">
        <property type="protein sequence ID" value="ORX18883"/>
        <property type="gene ID" value="AWC31_11945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.929"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008727">
        <property type="entry name" value="PAAR_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05488">
        <property type="entry name" value="PAAR_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="94" mass="8926" checksum="DACD9020C31D66AE" modified="2016-06-08" version="1">MPPAARVGDLTAHPGTIGPPGVPTVLIGGMPAAVVGTTHACAFPGVVPHPPNAILPPGCPTVLIGGMPAARVGDMTGCGAPILPPGCPTVLIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLF0</accession>
    <name>A0A132PLF0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">narY</name>
        <name evidence="2" type="ORF">AFM11_16680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850714.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01250"/>
    <dbReference type="EnsemblBacteria" id="KWX23007">
        <property type="protein sequence ID" value="KWX23007"/>
        <property type="gene ID" value="AFM11_16680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.686"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10557">
        <property type="entry name" value="NarH_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006547">
        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="546" mass="60782" checksum="9DBF720530E4656B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLG9</accession>
    <name>A0A132PLG9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850175.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23190">
        <property type="protein sequence ID" value="KWX23190"/>
        <property type="gene ID" value="AFM11_15285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7171"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="74" mass="8296" checksum="AE31CEAD92036043" modified="2016-06-08" version="1">MKTRSESELIADVQDRLVKRFNTFPAERVSAAVETAHHRFKGSVIRDFVPLLVERRVTSELESLSTAAPELVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLQ2</accession>
    <name>A0A132PLQ2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_15480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850243.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16295"/>
    <dbReference type="EnsemblBacteria" id="KWX23223">
        <property type="protein sequence ID" value="KWX23223"/>
        <property type="gene ID" value="AFM11_15480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7211"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="207"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="288"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX23223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="525" mass="57412" checksum="7B94D795A9BEFFB9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM06</accession>
    <name>A0A132PM06_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850543.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15785"/>
    <dbReference type="EnsemblBacteria" id="KWX23366">
        <property type="protein sequence ID" value="KWX23366"/>
        <property type="gene ID" value="AFM11_15165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7145"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="159" mass="16696" checksum="0A7CDFF2F5F1E1E3" modified="2016-06-08" version="1">MNPSPVIVLTAVAALASAAVGGIFYAFSTFVMRGLNRTGPTDAFTAMRGINAEANANPAFLLFFVGSALLALAVGVVALIQIGRPGSWLLLAGAIFGIVGFVITMVFNVPLNNRLDRADIADAAAEWQSYFTAWTAWNHVRTGTGFIGAVLMLAGLAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM12</accession>
    <name>A0A132PM12_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16105"/>
    <dbReference type="EnsemblBacteria" id="KWX23376">
        <property type="protein sequence ID" value="KWX23376"/>
        <property type="gene ID" value="AFM11_15660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7255"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="55" mass="5684" checksum="045820745BF9BE0B" modified="2016-06-08" version="1">MTMLMIDESGMSTVEYAIGTIAAAAFGAILYTVVTGDSIVSALSNIITRALNTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM36</accession>
    <name>A0A132PM36_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CarD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16015</name>
        <name evidence="3" type="ORF">AWC31_16590</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003921720.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16590"/>
    <dbReference type="EnsemblBacteria" id="KWX23314">
        <property type="protein sequence ID" value="KWX23314"/>
        <property type="gene ID" value="AFM11_16015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18018">
        <property type="protein sequence ID" value="ORX18018"/>
        <property type="gene ID" value="AWC31_16590"/>
    </dbReference>
    <dbReference type="GeneID" id="44295787"/>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7328"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="162" mass="17948" checksum="A8DB070D02EB0609" modified="2016-06-08" version="1">MIFKVGDTVVYPHHGAALIEAIETRTIKGEQKEYLVLKVAQGDLTVRVPAENAEYVGVRDVVGQEGLDKVFQVLRAPHTEEPTNWSRRYKANLEKLASGDVNKVAEVVRDLWRRDQERGLSAGEKRMLAKARQILVGELALAENTDDAKAETILDEVLAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM53</accession>
    <name>A0A132PM53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14160</name>
        <name evidence="3" type="ORF">AWC31_09240</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849730.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09240"/>
    <dbReference type="EnsemblBacteria" id="KWX23430">
        <property type="protein sequence ID" value="KWX23430"/>
        <property type="gene ID" value="AFM11_14160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09132">
        <property type="protein sequence ID" value="ORX09132"/>
        <property type="gene ID" value="AWC31_09240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6937"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="288" mass="30353" checksum="AB563799E01B13CE" modified="2016-06-08" version="1">MPGVQDRVVVVTGAGGGLGREYALTLAREGASVVVNDLGGARDGTGAGHNMADQVVNEIKEAGGRAVANYDSVAEPEGAENIIKTAIDEFGKVDGVVSNAGILRDGTFHKMTFENWDAVLKVHLYGGYNVIRAAWPHFREQSFGRVVVATSTSGLFGNFGQANYGAAKLGLVGLINTLAQEGAKYNIKTNAVAPIAATRMTQDILPPEVFEKLTPEYVAPVVAYLMTEELQDTDSVFIVGGGKVQRTALFQNEGVTFSDGVPSVDDVAAKWGEITDLSAAQQASFKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM81</accession>
    <name>A0A132PM81_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849695.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23413">
        <property type="protein sequence ID" value="KWX23413"/>
        <property type="gene ID" value="AFM11_14055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6915"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="437" mass="48262" checksum="BEC4164F1524D9B3" modified="2016-06-08" version="1">MDIGLWARWLALHAVPKSFMTVQAWRGNPMARLIVNHGRGNDPYPVMEDVRSRGRLIRTPFVWVTADHALCREILRDKRFGVTPPTGMEMPRALRMLLDRTDPGVANPVEPPAMVIVDPPDHTRYRQLVAQSFTPRAIETLDTRVAAVTSQLIDRLAANPRPDLIADYAAALPVAMIAEILGLPTETHARLLEWGHHGAPLLDIGIRWSTYRRAIAGLRGIDTYLNEHFRQVRAGAPSDNPFSRMAADHTLTDRELTANAALLIGAGFETTVNLIGNGIVLLLRNPDQLVLLRDNPDLWPAAVDEILRIDSPVQMTARTAQSDIEIGGQRLRAGDMVAVLLGGANRDPAVFDEPARFDITRPNVRDHLAFASGIHACLGAALARIEGTTALRALFEAYPDLHLTETPERRGLVNLHGYLRLPAHLGTARVEAAELFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM85</accession>
    <name>A0A132PM85_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14285</name>
        <name evidence="4" type="ORF">AWC31_09070</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849773.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09070"/>
    <dbReference type="EnsemblBacteria" id="KWX23451">
        <property type="protein sequence ID" value="KWX23451"/>
        <property type="gene ID" value="AFM11_14285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09101">
        <property type="protein sequence ID" value="ORX09101"/>
        <property type="gene ID" value="AWC31_09070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6965"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="99" mass="10415" checksum="3CEAD227D7BE4477" modified="2016-06-08" version="1">MAMNTDAAVLAKEAANFERISGELKSVIGQVESTAGTLVSQWQGQAGTAAQAAFLRYQEAATKQVQMLDEISANIHTSGTQYTSTDDDEAGTLSSAMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMK5</accession>
    <name>A0A132PMK5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_15025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17815"/>
    <dbReference type="EnsemblBacteria" id="KWX23568">
        <property type="protein sequence ID" value="KWX23568"/>
        <property type="gene ID" value="AFM11_15025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7116"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="211" mass="22500" checksum="F538904E79E37FFD" modified="2016-06-08" version="1">MARAHRGEETLRDDSRFEGGPRTPGGRRKRVDAQRNLGALLDAAKGVFARSGVDAPVKEILDAAGVGAGTLYRHFPQRADLVAAVLAHEIDECADAGPALSAAHEPAMALSLWLKRFTEFVATKRGLAGALHSGDPAFEALPGYFLQRLEPVVEHLITSAVGTGTIRTDVTARDLLYAVALLCQPVPGEGVAYNLRMVEIFIDGLHGPTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN65</accession>
    <name>A0A132PN65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849400.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23779">
        <property type="protein sequence ID" value="KWX23779"/>
        <property type="gene ID" value="AFM11_13475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6789"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="50"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="552" mass="59501" checksum="E1BB652D1892672F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN80</accession>
    <name>A0A132PN80_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septum_form domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_13600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849446.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23798">
        <property type="protein sequence ID" value="KWX23798"/>
        <property type="gene ID" value="AFM11_13600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6816"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026004">
        <property type="entry name" value="Septum_form"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13845">
        <property type="entry name" value="Septum_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Septum_form" evidence="3">
        <location>
            <begin position="72"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="184" mass="19466" checksum="E9943F5D7D37A419" modified="2016-06-08" version="1">MSTPPGPPPYGPPPGHGYPPPPPQPYSSESGQFPVPPKKSSALKWVLIAVVAVIALVVAAGVALYVFTQRDSTEASEVKSGDCLAEIPDSSRVLYVQTVPCDQPHKGEVFAVLPMPDGDFPGEAEVIKYTDKCAPALAEYSPATAEDSAIKLFVLYPTADSWQRGDRVVTCIATTESPRTGKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN83</accession>
    <name>A0A132PN83_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849427.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03790"/>
    <dbReference type="EnsemblBacteria" id="KWX23790">
        <property type="protein sequence ID" value="KWX23790"/>
        <property type="gene ID" value="AFM11_13545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6804"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="169"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="311" mass="33675" checksum="9A040631B81007D9" modified="2016-06-08" version="1">MPALPAVGSRVSLRYRLPSGSGKPLTDVIGHIERTEPTVRVRTKSGELVDVAPADIVSVRELSHAPVRASEIRALEHAAALAWPGTEHRWHRGWLLRAGLGATSRANSAVPLDLSAQIADVPAIVDWYRERGLPAWLALPERLLPIRAAGIKPTRVMVRDTPAPVPLPAIVTPAQPSTPNVTLAWQPDEQWLRIYERDVPVEVLTAVVDGTLTFASASDRAVGRGAVTAAPNGTKWLGISSVRVAADYRRQGHARAVCTTLLDWGAELGAQHAYVQVETDNAPAITLYTALGFRLHHHTRYVAAEDVITPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNE4</accession>
    <name>A0A132PNE4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849519.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23835">
        <property type="protein sequence ID" value="KWX23835"/>
        <property type="gene ID" value="AFM11_13830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6862"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453442" evidence="1">
        <location>
            <begin position="33"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="369" mass="38696" checksum="8388B6BF73908877" modified="2016-06-08" version="1">MRIKVRRLAVAAVAAVGLVLTGCSSGGGSGSAETNENGDLVIEGEVIATADVYQKAQQEGSLVFYTGGSEQSEKQAADAFTEATGINVEIVRLAPNRLSERILSEQAAGKLGADVIRISGEDLIVAIADSGAFQPTQISQGIADALDPAATYENGLYFNSYDRVYSFGYNNQVVSEQDAPKNWSDLLDPKWNGKLGIVQVGAGGSTTALTRFQLGELGADYLKGYAANHPRIFDSSAALTDSLARGEIAVGPVPIATAYASTLEGAPITIATPEEGAAAYPFYLGQAAKTEHSNAATVFINWLLSSSGQKLAASIGDYPVHKNMPSPTIGEIELPAADAGFLHRATIDESLKNLEPDAGTWRQIFGYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNF1</accession>
    <name>A0A132PNF1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_13145</name>
        <name evidence="5" type="ORF">AWC31_03430</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849249.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03430"/>
    <dbReference type="EnsemblBacteria" id="KWX23727">
        <property type="protein sequence ID" value="KWX23727"/>
        <property type="gene ID" value="AFM11_13145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11187">
        <property type="protein sequence ID" value="ORX11187"/>
        <property type="gene ID" value="AWC31_03430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6722"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="36"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="71"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX11187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="291" mass="33230" checksum="AB07286C91DAB607" modified="2016-06-08" version="1">MSQVESELAPYYEESQSIYDISNDFFALFLGPTMGYTCGYYERDDMTLDESQNAKFDLALGKLDLKPGMTLLDIGCGWGGALERALINYDVNVIGITLSKAQSDYARERLAKIDTQRHVEVRLQGWEEFNEPVDRIVSIGAFEAFKAERYPVFFERAYSILPENGGRMLLHTILAHTQKFFRENGIKLTISDLKFMKFIGEEIFPGGQLPAVEDIEKLADDSGFKLERIHLLQPHYARTLDMWAANLEAKKAEAIAMQGEEVYERYMKYLTGCADFFRRGITNIGQFTLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNH7</accession>
    <name>A0A132PNH7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_13670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849629.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03915"/>
    <dbReference type="EnsemblBacteria" id="KWX23896">
        <property type="protein sequence ID" value="KWX23896"/>
        <property type="gene ID" value="AFM11_13670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6830"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="440"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="559" mass="58670" checksum="14061361088319C0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNP5</accession>
    <name>A0A132PNP5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_13615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849625.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23894">
        <property type="protein sequence ID" value="KWX23894"/>
        <property type="gene ID" value="AFM11_13615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6819"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021734">
        <property type="entry name" value="DUF3303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11746">
        <property type="entry name" value="DUF3303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="89" mass="9962" checksum="E48179D5615A36CB" modified="2016-06-08" version="1">MKFIVHWTQTQANYREAVDKFKKTGAQVPDGVTMLGRWWGMNGQGFAIVETDDAKAMFESAAEWGEFLTMEITPAVEDAEAGEVLAKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNZ9</accession>
    <name>A0A132PNZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HD family phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848514.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10025"/>
    <dbReference type="EnsemblBacteria" id="KWX24068">
        <property type="protein sequence ID" value="KWX24068"/>
        <property type="gene ID" value="AFM11_11950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6470"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="171" mass="18789" checksum="33F8B949297B68AB" modified="2016-06-08" version="1">MQHVEEVGRVLRSLRGVWDEEAVDELDHALQSAARARADGADDELVLAAALHDLAHSPLFHGPHAEHHDLFAREWLSPRFGERVGWLAGAHVAAKRYLAATDPGYALSDTSAVSLRHQGGPGVDAEFVDHPWFSDALRLRRYDDAAKDPYADGMTIDDVLAVAERVARQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP50</accession>
    <name>A0A132PP50_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848642.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09785"/>
    <dbReference type="EnsemblBacteria" id="KWX24111">
        <property type="protein sequence ID" value="KWX24111"/>
        <property type="gene ID" value="AFM11_12190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6517"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="229" mass="23966" checksum="17D6FA8D3BD31783" modified="2016-06-08" version="1">MRNRLRVLAFDIAAPLAAIAALVFLGVALAWPLWWVSVCSVLCVLIVQGVVVNVVLARRDGVTVGTDDDGPGLRLAVVGVATAALIAAVVVGYLRWTVPDRTFEQDRGEVVRIASSVSEATATFTPQSPTASIDRAAGQMSPERAEAFKNEFATVAKDLTSRNVSAQASTISAGVEALGPQAASVAVVLRGTQSVPGKPTDNAVLALRVTLGKSDGRWLVDNVTPLHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPH2</accession>
    <name>A0A132PPH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_11605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848852.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30445"/>
    <dbReference type="EnsemblBacteria" id="KWX24174">
        <property type="protein sequence ID" value="KWX24174"/>
        <property type="gene ID" value="AFM11_11605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6398"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="287"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="433" mass="45459" checksum="4220CA253B6D8076" modified="2016-06-08" version="1">MANNTTRRRVAVLGGNRIPFARSDGAYANASNQDMFTAALDGLIDRFDLAGERLGAVIGGAVLKHSRDFNLMRECVLGSALSPYTPAYDIQQACGTGLQAATAAANAIALGQYEVAAAGGVDTASDAPIAFGNDLRRVLLGLRRAKSNVDRLKLVGKLPAALGVEIPVNSEPRTGMSMGEHAAVTAKKMGIKRVDQDELAAASHRNMAAAYDNGFFDDLVTPFLGLYRDNNLRADSNPEKLAKLKPVFGVKAGDATMTAGNSTPLTDGASVALLASEEWAAAHGREPLAYFVDAETAAVDYVNGPDGLLMAPTYAVPRLLARNGLTLQDFDYYEIHEAFASVVLATLAAWESDEYCKERLGLDSALGSIDRSKLNVNGSSLAAGHPFAATGGRIVAQLAKQLHLKKKETGQPVRGLISICAAGGQGVAAILEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ78</accession>
    <name>A0A132PQ78_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09430</name>
        <name evidence="4" type="ORF">AWC31_05795</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847907.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05795"/>
    <dbReference type="EnsemblBacteria" id="KWX24473">
        <property type="protein sequence ID" value="KWX24473"/>
        <property type="gene ID" value="AFM11_09430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10294">
        <property type="protein sequence ID" value="ORX10294"/>
        <property type="gene ID" value="AWC31_05795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5923"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX10294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="263" mass="28897" checksum="175AF0AA4AEA5A24" modified="2016-06-08" version="1">MDMVYSLGVAAAAVLVLAWVCVSNVRVVKQYERGVVFRFGRVQNHVRPPGLTMLIPVADRLQKVNMQIITMPIPAQDGITRDNVTVRVDAVIYFNVIDPVRAVVDVQDYMSAIGQVAQTSLRSIIGKSNLDDLLSNRERLNQGLELLIDNPAVSWGIHIDRVEIKDVVLPDSMKRSIARQAEAERERRARVITADGELQASEKLAAAADVMAAEPAALQLRLLETVVEVAAEKNSTVVLPFPVELLRFLERVTPGPSSTRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQH7</accession>
    <name>A0A132PQH7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847863.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19430"/>
    <dbReference type="EnsemblBacteria" id="KWX24457">
        <property type="protein sequence ID" value="KWX24457"/>
        <property type="gene ID" value="AFM11_10915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6222"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="436" mass="48091" checksum="E0AA4DD314DD4CD3" modified="2016-06-08" version="1">MKISLFYEFPLPRPWSEDDEHQLFQHGLTEVEAADKAGFSTVWLTEHHFLEEYCHSTAPEMFLAAASQRTKDIRLGFGVMHLPPPINHPARIAERIATLDHLSNGRVEFGTGEGSSVAELGGFNIDPADKRAQWEEALEVAIRCMVEEPFSGFKGEHVEMPARNVIPKPLQKPHPPVWVACTRPSSVQMAAQKAIGALSFAYTGPEALKDRVEGYYKEFEEQGTPVTPVINPNILAIGGDLSMMVAKSDEEALKRLGIGGGFFSFGIMHYYLTGMHTPGRTKVWERYEQAVADDPSLAYGPGRGAIGSPDTVREFLRGYEASGVDEIILLLNPRSHEGTMESIEIMGKEILPEFIERDAKAVADKAKRLEPVIEKVEARRQRSDAPLFDETYAFGGLPTGRGGKFTAGEIPEAMAEINEGRVKAAQQEKAAREQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQN2</accession>
    <name>A0A132PQN2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_10250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847538.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18695"/>
    <dbReference type="EnsemblBacteria" id="KWX24352">
        <property type="protein sequence ID" value="KWX24352"/>
        <property type="gene ID" value="AFM11_10250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6088"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="21769" checksum="D31DF44C4919A262" modified="2016-06-08" version="1">MSASAVTRRSQAKSDRRSQLITAAERLVAERGYLAVRLEDIGAAVGVSGPAIYRHFPNKEALLVELLVGISTRLLAGAREVIARTDDPAEALDGLVDFHLDFAFGESDLIRIQDRDLGHLPDAAKRQVRRAQRQYVEIWVSVLTRVDRDLPEDDARVMAHAAFGLLNSTPHSVRPAAPKAQSREVLRRMTIAALTATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQQ0</accession>
    <name>A0A132PQQ0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_08245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846359.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24656">
        <property type="protein sequence ID" value="KWX24656"/>
        <property type="gene ID" value="AFM11_08245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5500"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="361" mass="39138" checksum="4E3AAEB6BB8792D2" modified="2016-06-08" version="1">MTTPTLTSEPTGLHQHGRPVRLDRLEKHYGDTAAVNGVDLDIRGGELLTLLGASGSGKTTLLSMIAGFTTPTSGRVTIADEDITRTPPHRRNIGMVFQHYSLFPHMNVRVNVEFPLKQRGVTRADRRRRALEALDIVELGHKADARPGELSGGQQQRVALARALVFSPSLLLMDEPFGALDRALRERMQLEVRRIHRDLGVTIVFVTHDQQEALTMSDRIAVMNNGRIEQVGTPEELYESPASFYVATFLGESNVLTGSCSGGVLTTSGGSRLRVPAGVDGLARLVIRPERIVVDSESDSRAAAFSASVAEVVYLGSDRRLVANTPDGEFVARIPASGTTYRPGDSITLSWAADDACLFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQR0</accession>
    <name>A0A132PQR0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846391.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00190"/>
    <dbReference type="EnsemblBacteria" id="KWX24666">
        <property type="protein sequence ID" value="KWX24666"/>
        <property type="gene ID" value="AFM11_08300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5511"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="156"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="30700" checksum="84B560927A11D92D" modified="2016-06-08" version="1">MTSSAAPVVVGIDGSDSAVNAARWAGAVAEKLGTPLHVLHALPTIGRNLTQTAGAMVAAMMSYQQDCAEIFLKAAVEAVSAERPGLQITTASVNEPADEALIAASAQARLVVLGGKAVTPAAALLIGSTALAVTTRAACPVVAFRGDRVAPGDGPIVVGVDDSPAAENALTTAFELADRLGVPLKAVRSLSFAVPAETGVTIPFVIDWEALEVAELTALTETVDAQNKRHPDVDAKCFVEPVSPGKAIMRHADGAELVVVGTRGRNALAGVVLGSTSLNMLHHSAVPVLVCRADRQGDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQR2</accession>
    <name>A0A132PQR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBP-type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08320</name>
        <name evidence="4" type="ORF">AWC31_00210</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000001">
        <property type="protein sequence ID" value="ORX19321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846403.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00210"/>
    <dbReference type="EnsemblBacteria" id="KWX24670">
        <property type="protein sequence ID" value="KWX24670"/>
        <property type="gene ID" value="AFM11_08320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19321">
        <property type="protein sequence ID" value="ORX19321"/>
        <property type="gene ID" value="AWC31_00210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5515"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX19321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="115" mass="12551" checksum="18EF06E5A190CD75" modified="2016-06-08" version="1">MSDTVDPTAPPSGTGCAECDAVGGWWVHLRRCAACGHIGCCDDSPARHASAHWRATGHPIIRSFEPGEDWFWNFDTNAYADGPELAPPQHRPADQPVPGPRGRVPADWAAQLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQT6</accession>
    <name>A0A132PQT6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_08505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846489.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00360"/>
    <dbReference type="EnsemblBacteria" id="KWX24699">
        <property type="protein sequence ID" value="KWX24699"/>
        <property type="gene ID" value="AFM11_08505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5549"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="84"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="304" mass="32296" checksum="657E6B01EC1376B3" modified="2016-06-08" version="1">MTSTLEQPVKAPAFQGVSVRRKLTNNFATVLVTLSVLIALVPLLWVLYSVITKGFAAITSPVWFTNSQSGMTAFSPGGGVYHAIVGTLLQGIVCSLISIPIGVMVAVYLVEYGGGTRLGRITTFMVDILTGVPSIVAALFIYALWVATLGFERSGFAVSLSLVLLMIPVIVRATEEMLRIVPMDLREASYALGVPKWKTIVRIVIPTALSGIVTGVMLALARVMGETAPLLILVGYAQAMNFDMFGGFMGSLPGMMYDQISAGAGANPVPTDRLWGAALTLILLIALLNVGARFVAKIFAPKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR10</accession>
    <name>A0A132PR10_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08975</name>
        <name evidence="4" type="ORF">AWC31_13395</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846715.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13395"/>
    <dbReference type="EnsemblBacteria" id="KWX24778">
        <property type="protein sequence ID" value="KWX24778"/>
        <property type="gene ID" value="AFM11_08975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18312">
        <property type="protein sequence ID" value="ORX18312"/>
        <property type="gene ID" value="AWC31_13395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5645"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="229" mass="24684" checksum="DE791109EA18D31F" modified="2016-06-08" version="1">MSEDTALETSRPVRRRASRAAGPAAGEATATTTAEVRVEPPVTKVRVAKPVKAPPRRRPNGRLVAIVAAAVLAVATVGMGVLTYVMVDQQRTVDAAQARDERFVDTAKQTVVNMFSYTQETIDESVNRFVDGTSGPLRDMMSQGNNVDNLKALFRDTNASSEAVVNGAALEKVDEIANNASVLVSVWVTVTDLDGVNSPTRPYRLRVIVHEDDNGHMTGYDLKYPDGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR32</accession>
    <name>A0A132PR32_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketoacyl-ACP reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabG</name>
        <name evidence="2" type="ORF">AFM11_09020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846739.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13350"/>
    <dbReference type="EnsemblBacteria" id="KWX24786">
        <property type="protein sequence ID" value="KWX24786"/>
        <property type="gene ID" value="AFM11_09020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5654"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="309" mass="31871" checksum="752DFFF4BEC2873E" modified="2016-06-08" version="1">MTTNSSADAQIDLSGKVAVVTGAAAGLGRAEAIGLAQAGATVVVNDMAGALDKSDVLDEIASAGSKGVAVAGDISQRSTADELVATADGLGGLNIVVNNAGITRDRILFNMTDEEWDAVIAVHLRGHFLLTRNAATYWRAQAKAGDGTVYGRIVNTSSEAGLSGPVGQPNYGAAKAGITALTLSAARALERFGVRANAIAPRARTAMTADVFGDEPKLADGQVDPLSTDHVVTLVRFLCSPASEAVNGQLFIVYGPTVTLVAAPTAEKHFTANADAWAPADLGATLHEYFADRDPERGFSATELMMSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR76</accession>
    <name>A0A132PR76_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845960.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21965"/>
    <dbReference type="EnsemblBacteria" id="KWX24830">
        <property type="protein sequence ID" value="KWX24830"/>
        <property type="gene ID" value="AFM11_07465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5341"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="22499" checksum="572E6B2365277D5E" modified="2016-06-08" version="1">MSEFVTPVVLTGEQWVTLEPLTRAHIPEIDDVAADGELGTLWYTMTPAPGAAEWWVERMLQLRAADHGVSFVVRSLDGRLVGSTSYLNVDGPNRRLEIGHTWYTAAARGTGVNAEAKLLLLSHAFDELRCVAVEFRTHFFNFASRAAIERLGAKQDGVLRSHQLGPDGTRRDTVVYSIIDIEWPAVRSNLKFRLDRRGRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR85</accession>
    <name>A0A132PR85_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA carboxyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_07705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846082.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22185"/>
    <dbReference type="EnsemblBacteria" id="KWX24562">
        <property type="protein sequence ID" value="KWX24562"/>
        <property type="gene ID" value="AFM11_07705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5390"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="4">
        <location>
            <begin position="213"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="490" mass="51299" checksum="85881E2D010C102C" modified="2016-06-08" version="1">MSRIGALALRDAVLDEGSFHSWDAPPLDVATSDEYRRELAEASSKTGLDESVLTGEGTVFGRRVAVVACEFDFLAGSIGVAAAERITAAVQRATAEGLPLLASPSSGGTRMQEGTVAFLQMVKIAAAVELHKQAHLPYLVYLRHPTTGGVFASWGSLGHVTAAEPGALVGFLGPRVYEHLYGEPFPAGVQTAENLHAHGVIDGVVPLALLRDTLDRTLRVVADPPGPPPQAAPPEPLPDVPAWESVEASRRPDRPGVGFLLRHGATDRVLLSGTERGEAATTLLALARFLGQPAVVVGQRRIVGGLVGPEALREARRGMALAAELRLPLVLVIDTAGPALSTEAEQGGLAGEIARCLAELVTLDTPTVSVLMGQGSGGPALAMVPADRVLAASNGWLAPLPPEGASAIVYRDTEHAAELAAAQGVRAMDLLRHGIVDVVVPELPDAADEPRAFTARLSTAIATELHALRAVPGEQRLQARLERYRRIGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRG4</accession>
    <name>A0A132PRG4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_08720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846985.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13650"/>
    <dbReference type="EnsemblBacteria" id="KWX24854">
        <property type="protein sequence ID" value="KWX24854"/>
        <property type="gene ID" value="AFM11_08720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="149" mass="15526" checksum="DB33753420624A66" modified="2016-06-08" version="1">MAIFLTLVLGTLAARGLGLWGVDYVDTWPEAIAVGLAAMFVLTGVAHFVNPLRRDMIAIVPPRLPAPAALVTITGVLELAGAIGLLYPPTRVAAAVCLFLLMLAMFPANVYAARMPDPPKSMTARLGVRTAEEAVYLAAAVIVGIGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRK3</accession>
    <name>A0A132PRK3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_08330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846409.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00220"/>
    <dbReference type="EnsemblBacteria" id="KWX24672">
        <property type="protein sequence ID" value="KWX24672"/>
        <property type="gene ID" value="AFM11_08330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5517"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="199" mass="21816" checksum="0B1712EE6079931D" modified="2016-06-08" version="1">MARPAQTARSERTREALRQAALVRFLAQGVEDTSAEQIAADAGVSLRTFYRHFNSKHDLLFADYDAGLHWFRAALAERPAGESILDSVQSAILAFPYDVDAVTKIAAMRSSELDPGRIVRHIRQVETDFAEAVADHLAKREPAAPQGDDLLRVVVTARCVAAAVFGAMELWMAGDEERTLPELARLCRAGLESLRSGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRK6</accession>
    <name>A0A132PRK6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13080"/>
    <dbReference type="EnsemblBacteria" id="KWX24827">
        <property type="protein sequence ID" value="KWX24827"/>
        <property type="gene ID" value="AFM11_09290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5706"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021315">
        <property type="entry name" value="Gap/Sap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11139">
        <property type="entry name" value="SfLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="267" mass="29031" checksum="D7A8F56DB8C90DC7" modified="2016-06-08" version="1">MWGIVVLSSLMTAFNPVRVGIVLLMVSRPRPMRNLFVYWIGCLIVGIPPVVGSLMVLNYTAQSLTGSSSNPVMRHVQVGLGVLALAIALWVALRPLWQKRFGSSVKAKRNNRATRLSRDVPADPGAETPVVVSTLPRTETAGQGGKDPLFRRLLNRIRRIWEGDSLWVALLMGLGTGPPADGMFIVITTIFAAGVGLGTQFTAGIVYLLGTLLVIELILVCHVISPTRTQQMMQQLHDWTRAHFRPLIVGLFGMIGTFAVVTGLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRK8</accession>
    <name>A0A132PRK8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ORF">AFM11_06015</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845172.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29645"/>
    <dbReference type="EnsemblBacteria" id="KWX24988">
        <property type="protein sequence ID" value="KWX24988"/>
        <property type="gene ID" value="AFM11_06015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4394"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="196"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX24988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="225" mass="23613" checksum="D1F3A15180348FD1" modified="2016-06-08" version="1">MAEPLIAPSILSADFARLADEVAAVSGADWLHVDVMDNHFVPNLTLGLPVVESLLKVTDIPMDCHLMIENPERWAPPYAEAGAYNVTFHAEATDNPVAVARDIRAAGAKAGLSVKPGTPLEPYLEILREFDTLLVMSVEPGFGGQKFIPEVLAKVGTARRLVDSGELTVVVEIDGGVNADTIAQAAEAGVDCFVAGSAVYSAADPAAAVKSLRQQAASASKHLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRL9</accession>
    <name>A0A132PRL9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">whiA</name>
        <name evidence="9" type="ORF">AFM11_06080</name>
        <name evidence="10" type="ORF">AWC31_29580</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29580"/>
    <dbReference type="EnsemblBacteria" id="KWX24998">
        <property type="protein sequence ID" value="KWX24998"/>
        <property type="gene ID" value="AFM11_06080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13920">
        <property type="protein sequence ID" value="ORX13920"/>
        <property type="gene ID" value="AWC31_29580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4408"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WhiA_N" evidence="7">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="8">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_WhiA" evidence="6">
        <location>
            <begin position="221"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX13920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="327" mass="35020" checksum="4D27A455C3217539" modified="2016-06-08" version="1">MAMTAEVKDELSRLVVNSVSARRAEVASLLRFAGGLHIVAGRVVVEAEVDLGIIARRLRKDIYDLYGYNAVVHVLSASGIRKSTRYVVRVANDGEALARQTGLLDLRGRPVRGLPAQVVGGSVGDAEAAWRGAFLAHGSLTEPGRSSALEVSCPGPEAALALVGAARRLGVSAKAREVRGSDRVVVRDGEAIGALLTRMGAQDTRLTWEERRMRREVRATANRLANFDDANLRRSARAAVAAAARVERALQILGDTVPDHLAAAGKLRVEHRQASLEELGRLADPPMTKDAVAGRIRRLLSMADRKAKQDGIPDTESAVTPDLLDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRZ6</accession>
    <name>A0A132PRZ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09120</name>
        <name evidence="3" type="ORF">AWC31_13250</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846799.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13250"/>
    <dbReference type="EnsemblBacteria" id="KWX24802">
        <property type="protein sequence ID" value="KWX24802"/>
        <property type="gene ID" value="AFM11_09120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18288">
        <property type="protein sequence ID" value="ORX18288"/>
        <property type="gene ID" value="AWC31_13250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5673"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="77"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="236"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="333" mass="36456" checksum="4778B4295278EB35" modified="2016-06-08" version="1">MTASQSSPASIDRREPPLSAPLKLSFDYTRSVGPLLSQFFTALRERRIVGVRGSDGRVHVPPAEYDPVTYEALTEVVPVASVGTVMSWTWQPEPLEGQPLDRPFAWALIKLDGADTPMLHAIDAAEGAVSTGMRVHAHWVDEPVGAVTDIAYFVPGETPEPVPDTADDRDPVTMLVVPTAIEIQHTASLPESTFLRALQEGKLLGARTVGKNGEKGKVYFPPKEADPATGKELTEYVELPDKGTVTTFAIINIPFAGQRIKPPYVAAYVLLDGADIPFLHLVTEIDASEVRMGMRVEAVWKPQEEWGLGIDNISHFRPTGEPDADYDTYKHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS10</accession>
    <name>A0A132PS10_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846829.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24812">
        <property type="protein sequence ID" value="KWX24812"/>
        <property type="gene ID" value="AFM11_09180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5685"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="423" mass="44289" checksum="992B848D93D22F43" modified="2016-06-08" version="1">MSRHAQASPTDDGMLAVGRALLYPGLALTSLLILRGPMALPYGDMLMAGAGFCALLSMNRPARSLPVALYIVAPLLVVGTLISSAVSEDPVGSVSIAVRLIYLVVLVPWILVNLLTERRHVVTAYAWFMSGAALCAVGAVAQLIWGDVIPGGAVTVDGRFTGMTTHQNDLAGISCMAAAAMLAAVGATIPRGVRIGALAILSASLVGLVLSGSVSGLLGLAAAVAYLLIRGTVRIGRALGITAAGALLLAILLPQLDSIGALNPIERLTRTTGFSASQSEYDTAGTRLELMRLAVDAIADSPFVGRGMLIADNVLMKRFTVHNNFLGTWTAGGVLVFLGVVIATVIALRFCLSRQSRRDPLHNTVATSVIAALVFAQTAPGFYNRYYWIPVAFAIYLVVDLRYTRSASVPSHTPTATYGVARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS77</accession>
    <name>A0A132PS77_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFM11_06975</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845519.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28675"/>
    <dbReference type="EnsemblBacteria" id="KWX25155">
        <property type="protein sequence ID" value="KWX25155"/>
        <property type="gene ID" value="AFM11_06975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4594"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="22"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KWX25155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1518" mass="164319" checksum="894F62C666C5D034" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSD7</accession>
    <name>A0A132PSD7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_07145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845637.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17570"/>
    <dbReference type="EnsemblBacteria" id="KWX25184">
        <property type="protein sequence ID" value="KWX25184"/>
        <property type="gene ID" value="AFM11_07145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4627"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="36"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="170" mass="17820" checksum="EE6D94ACE9176144" modified="2016-06-08" version="1">MTTGDFQPQPGPYGQPGGYPPPYGAQPRYGTQAPGGLARRFFARVIDGIVVGIVAFFLAFFTDSLSSYWVTGLFTGLLMFVYFVGFEVTQGWTPGKKMLGLAVQGPGGAPKPTAAQSAIRNAFTLLPIIPLVGGFLGVVAIIVIAVTVSGSPTKQGKHDDLAGGTQVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSF3</accession>
    <name>A0A132PSF3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">AFM11_02965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843789.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25276">
        <property type="protein sequence ID" value="KWX25276"/>
        <property type="gene ID" value="AFM11_02965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2458"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="129"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="29741" checksum="98A7C8C3D474201F" modified="2016-06-08" version="1">MSAIAIDGTVVAKRILDETRHRAAHFARSHGRKPCLATVLVGEDPASQTYVRMKTNRCRSTGLDSQRHSLPQNASTAQAVELVTELAGDDAVDGILVQHPMPIQIDERQVFEAITPTKDVDGLTGASFSAMALGGAGFQSCTPGGIVRLLDAYAVDPSGQHAVVIGRSPILGKPVGMLLLSRDATVTYCHSKTSKLSAIVSDADIVVAAVGRPELIKGDWIKPGAVVIDAGYNPGNIGDVEYPAAAQRARLITPVPGGVGPTTIAVLLAQTVDAAEHNALSASSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSF5</accession>
    <name>A0A132PSF5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_06445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29230"/>
    <dbReference type="EnsemblBacteria" id="KWX25253">
        <property type="protein sequence ID" value="KWX25253"/>
        <property type="gene ID" value="AFM11_06445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4482"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="464" mass="50362" checksum="201CE05DDC373083" modified="2016-06-08" version="1">MATSPTVGAGETNKRAAHGDDRLTYLDQAMYLGLRATGQAAVMRCVWIYEHPVDLDGLRRFHRNFGSGLAGRRIEPSALPFGRHRWVSSLGPPADIDIAEHARPRDELGDWLDERAALPVDPEWGPGWHLGVLPMTDGSTAISLVGSHCLGDGGGALLTVLEAVTGNVRDLGYRQPRSRTRRQALAEDTRQFLHDFPEVGRTLVAAGKLALRRRKERVAAAPARKPPVTQWEDNRHVRVPALTAFVDLADWDARATSLGGNTYSLLAGFAAKLAEAMNRRAADGKVPLIIPINDRTDLADTRANAVKLANVSADPDGVTRDLSALRSDIRQSLRKLDDTPDEAMELLPLVPFMPKRAVKHAAELAFGFTEQPVSCSNLGDLPAEIGRADGTDAEYVLLRGVDQHITRRVLEQRSGLLTVVGARIGGRISITVVGYELGAANTRARLRGLVEHTLSEFGLSGVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSS4</accession>
    <name>A0A132PSS4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844105.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21545"/>
    <dbReference type="EnsemblBacteria" id="KWX25373">
        <property type="protein sequence ID" value="KWX25373"/>
        <property type="gene ID" value="AFM11_03610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2597"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="405"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="623" mass="68946" checksum="FB5EE14ECDB6E3FE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTT4</accession>
    <name>A0A132PTT4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excinuclease ABC subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25723">
        <property type="protein sequence ID" value="KWX25723"/>
        <property type="gene ID" value="AFM11_05195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2921"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="237" mass="26595" checksum="D344678763CF219F" modified="2016-06-08" version="1">MPTAFVRGFRELLAEALDSVDPASGKRLGSCIGVYAFYDYDKEPIYVGQTREDFGTRIGRHLRGQRSDTLAYRILDPFEVAEMELYPLEFLRDEPTPDKKAKVDAVEYSAYVHAISESKYKAILNEKIPPVSEPVELPPHFRFNLIPEGMREEREHPDVRIARRAETLARVAAVAHERGEVSAGLRRVIVIQAVRLADLAAARLAYAEGRKRPDPASIDVPALVGNVMKEFTESDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU36</accession>
    <name>A0A132PU36_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844534.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20620"/>
    <dbReference type="EnsemblBacteria" id="KWX25707">
        <property type="protein sequence ID" value="KWX25707"/>
        <property type="gene ID" value="AFM11_04525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2783"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="140" mass="15505" checksum="600BC9A794B568AF" modified="2016-06-08" version="1">MAEAAIRQRIDDAVGAVRSRDIDTLTSLYAPDVVSFDVGAPLRYTGRDNKRRAWDEFFAAYAGPIAYDVHELNVTTQGDVAFVHSLNHVSGTLVNGRVTDMWVRWTACFTRVDGVWLVAHDHVSVPADLEFGKAMVNLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU45</accession>
    <name>A0A132PU45_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00570</name>
        <name evidence="6" type="ORF">AWC31_33685</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842311.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33685"/>
    <dbReference type="EnsemblBacteria" id="KWX25825">
        <property type="protein sequence ID" value="KWX25825"/>
        <property type="gene ID" value="AFM11_00570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11639">
        <property type="protein sequence ID" value="ORX11639"/>
        <property type="gene ID" value="AWC31_33685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.117"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="220" mass="23895" checksum="73016E6F437553D3" modified="2016-06-08" version="1">MAPSSPVRLVLVDDHEMVIEGLKAMLAAFADRVQVVGQAVGAERALGVVEDLNPDIVLCDVRMQGSSGLDLCRTLRERDPDRKVVMLSVYDDEQYLFQALRVGASGYLLKSISSDELVRQLEFAHGGETAIDPGMAARAAGTAARLQRDEFWPGVRQGLTQRESEILSYVVAGLSNRGIANKLVIGDETVKTHLRSIYRKLGVGDRAGAVATALREGIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU55</accession>
    <name>A0A132PU55_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_04925</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844678.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25582">
        <property type="protein sequence ID" value="KWX25582"/>
        <property type="gene ID" value="AFM11_04925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2866"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="301"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX25582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="469" mass="50306" checksum="F7A805FA12AD8CF9" modified="2016-06-08" version="1">MERLSALDAGFLEAEDSDPHVSLAIGALAVMAGPMPEFESLVAALAERVTAVPRLRQVLKTRPLDLGAPQWVVDPNLDLARHVRRAALPRPGDDTALYGWVAEVMERRLDRDHPLWQCWVVDGLPYNRWAILMKIHHCIADGVAASHLLARLCDDIDADTVEPTARGEMPRGGFRLPLPSINPVDWVTGAWQSTQAFAAAATQIVHGAGEIVGSLLRPAESTLAGPVTDMRRFAGAEVSLADVARICERFDVTVNDVALAAITGSFRSLLIRRGNEPKANSLPTLVPVSVRSQAGTATADNRISVMLPYLPVEKADPVTQLQAVHERMTRAKASGQRQAGSALVTAANAIPFALTAWAVRALTRLPQRGVSMLATNVPGPRHRLRVMGREVIRLLPVPPIALRLRAAVAVVSYAQHLCFGITADYDAAIDVDELASGIDQAVTRLAQISVAPTRSTPLGTLALVPGAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU95</accession>
    <name>A0A132PU95_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_00950</name>
        <name evidence="11" type="ORF">AWC31_33980</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842506.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33980"/>
    <dbReference type="EnsemblBacteria" id="KWX25890">
        <property type="protein sequence ID" value="KWX25890"/>
        <property type="gene ID" value="AFM11_00950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11690">
        <property type="protein sequence ID" value="ORX11690"/>
        <property type="gene ID" value="AWC31_33980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.196"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="36"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="237"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX11690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="447" mass="47437" checksum="00C6E183277FA807" modified="2016-06-08" version="1">MSAQMTFADLGLPAEIVATLAANGIEAPFPIQAATLPDSLTGRDVLGRGRTGSGKTYAFLLPLVARLSATRTRPAPGRPRALILAPTRELVTQIEASLTALAKATGLSSVNIFGGVGPGPQIAALRRGVDIVIACPGRLEDHVKSGHADLSAVEITVLDEADHMADLGFLPGVKRLLDRTPKRGQRLLFSATLDAGVDVLVKRYLHDPVVHSVDSAQSPVSAMVHHVLHVDNSARVNVVADLAAAPGRTIVFARTKHGAKNLTRQLNSRGISAVELHGNLSQNARTRNLTAFSDGSATVLVATDIAARGIHVDDVSLVVHADPPVEHKAYLHRSGRTARAGAEGTVVTLMHDAQVSDVRQLTRKAGVKPTITRVNGLDHPVLREIAPGERVFGEPKAPARPEPKAPQRSERSGSRRPRSTSRGDHAPKAHASRGGRRRPRRSNDSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUR0</accession>
    <name>A0A132PUR0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aspA</name>
        <name evidence="3" type="ORF">AFM11_02075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843058.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34855"/>
    <dbReference type="EnsemblBacteria" id="KWX26055">
        <property type="protein sequence ID" value="KWX26055"/>
        <property type="gene ID" value="AFM11_02075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.425"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="2">
        <location>
            <begin position="412"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="472" mass="49576" checksum="2ACE8901DB34664F" modified="2016-06-08" version="1">MTSARPTRTEHDLLGDHEVPADAYYGVHTARALENFPISGVPISRHPDLVIALAAVKQAAAEANRQLGQLDDTTADAIVRACVEIRGGALHDQFVVDQIQGGAGTSTNMNANEVIANRACELLGHDRGAYRIVHPLEHVNLGQSTNDVYPTAVKIALGTATRTLEQALRGLAGHCSTKSLEFADMLKLGRTQLQDAVPMTLGQEFGAFAVTIIEDADRLREASALIAEINLGGTAIGTGLNTHPRYAALVCERLRALTGLPLTTAGNLVEATSDVGAFVQLSGVAKRSAVKLSKICNDLRLLSSGPRAGFGEINLPPVQAGSSIMPGKVNPVIPEVVNQVAFEVIGNDLTVTMAAESGQLQLNAFEPIIARALLSSLTHLTAAVTVLGDRCIAGITANADRMRQAVLQSASIATALNPVLGYEAATALVAEAIATGASIPELVRRSALVDDAVLDRVFSPENLCGPNDPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUW0</accession>
    <name>A0A132PUW0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA topoisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_02630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843361.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35405"/>
    <dbReference type="EnsemblBacteria" id="KWX26149">
        <property type="protein sequence ID" value="KWX26149"/>
        <property type="gene ID" value="AFM11_02630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.539"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.66.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035447">
        <property type="entry name" value="DNA_topo_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55869">
        <property type="entry name" value="SSF55869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topoisom_I" evidence="5">
        <location>
            <begin position="82"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX26149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="338" mass="37976" checksum="FB20528E9FDFA720" modified="2016-06-08" version="1">MRLRRSVVRGPGLHRVRRGRGFSYQDDDGRTVTDKATLQRIEALVIPPAWKTVWICPYANGHIQAVGTDAAGRRQYLYHQQWQAERGEEKFDRVLELSAALPDWRKHIAKDLTTRGLPRDRVLALGLRLLDLGYFRAGGDQYAEENNSFGIATLQCEHVTVHTDSVEFDYPAKSGVRRTLIVSDSEVVRAARALQRGRKPGDRFLVCRNSAGCTDIHAEDLNIRFKEMVGEEYTVKDLRTWHGTVLAAESFVEADPPVDDKVIKRVESAVMREVAEALGNTPAVARSAYVDPRVVEGYRDGITIAAGLRRAERIKDADERQAVVERSTARMIRKVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV88</accession>
    <name>A0A132PV88_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="6 10">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_02205</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="6 10"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843132.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34985"/>
    <dbReference type="EnsemblBacteria" id="KWX26077">
        <property type="protein sequence ID" value="KWX26077"/>
        <property type="gene ID" value="AFM11_02205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.451"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011269">
        <property type="entry name" value="PUNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01698">
        <property type="entry name" value="PUNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="12">
        <location>
            <begin position="31"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="11">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX26077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="269" mass="27907" checksum="27949B264B5AC5AF" modified="2016-06-08" version="1">MTDSPASVAQDSLRASAQAIAERTGVEHHDVAVVLGSGWAPAVAELGDPVAVVPMAELPGFTPPSAAGHGGQVLSVRIGAHRVLVLVGRIHAYEGHDLQHVVHPVRTAAATGVRTVVLTNAAGGLRPEYEVGQPVLISDHLNLTARSPLVGAQFVDLVDAYSPRLRALAREIEPDLAEGVYAGLPGPHYETPAEIRMLRTLGADLVGMSTVHETIAARAAGAEVFAVSLVTNLAAGMTGQPLSHAEVLEAGRQSATRMGSLLASVIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV89</accession>
    <name>A0A132PV89_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843721.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26279">
        <property type="protein sequence ID" value="KWX26279"/>
        <property type="gene ID" value="AFM11_02140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.439"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="96" mass="9536" checksum="C0CB5A830A010359" modified="2016-06-08" version="1">MLADTATIRTLGHAYVTHAADLAAVAAALRAIPSPPDALGPVGDRFLTAFTAALSDQSNAVAALGERAQAASRTAAHNAASFDAAGDRAAGLLPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PW63</accession>
    <name>A0A132PW63_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_01715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843667.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26262">
        <property type="protein sequence ID" value="KWX26262"/>
        <property type="gene ID" value="AFM11_01715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.353"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX26262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="389" mass="40277" checksum="D521B325C28BE41F" modified="2016-06-08" version="1">MVVATLDAIGLGLVMPVLPALLRLHVAPSAVAVQIGVLIAIYAAMQLVFAPILGWLSDRFGRRPVLLASLAGACVDYLAMATVPTLWMLYVGRAVAGLTAATTAVVGSVVADISEGDQRAGRYGVMGACYGGGMIAGPAIGGVLGSVSPHLPFLMAAALSSFALIVAFFALRETRTPDAHLAIPAGTPAPGRRMPRSPGGAVLPSLLFVYFIMQFVGQAPATMWAVFTEHRFDWTPTHVGLSLTAFGAIHALAQASLAGPLSTRLGSDHAVVVGISLDAIGLLALSAAGQGWMMLPISLLLALGGVGMPALQTLLTNQVDDRHQGRLQGAMASLTSLTGIVGPLLFAALYGATAQRWDGWLWIGGAASYLVCIPALRIAFTRRPLTIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAQ8</accession>
    <name>A0A132PAQ8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF222 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_36015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000068">
        <property type="protein sequence ID" value="KWX19410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19410">
        <property type="protein sequence ID" value="KWX19410"/>
        <property type="gene ID" value="AFM11_36015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF222" evidence="1">
        <location>
            <begin position="39"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="26923" checksum="DF90600BF73ED074" modified="2016-06-08" version="1" fragment="single">MDSLVADRLAALRAALAGVRDLPWGSLPEADLLEVCAGVQEVRNLVPVVEHAAISALSECTTPAAVGAKSWPEALRIRLRISGTEARRRVRDAMNFGPRRSVTGEALAPVRAATAAAQAGGWLTPDHVDELETFFTKCPDWVNAARRDAFERKLVAVAAQETPETVRHTVAEALYLLNQDGEEPVDAAERKRGLVIHPQQPDGTSKVSGWLNAEARAVVEPLLAKYAAPGMCNPDDPAPCVTGVPSEEAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB48</accession>
    <name>A0A132PB48_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19549">
        <property type="protein sequence ID" value="KWX19549"/>
        <property type="gene ID" value="AFM11_35255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="126" mass="13144" checksum="1B8D999C70C9BABC" modified="2016-06-08" version="1">MLAAAQPPAFVGIVSGGVQDSRRNRVARNAPGLAMWSGQVVPRACMSALRASLIARADHTAGSMPALVSASQMAPMWARSRPWVSATSPAASFWVASGRAAARRGRACRVLSQHRLAGALARPLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBL6</accession>
    <name>A0A132PBL6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19719">
        <property type="protein sequence ID" value="KWX19719"/>
        <property type="gene ID" value="AFM11_34315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5205"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021223">
        <property type="entry name" value="AbiGi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10899">
        <property type="entry name" value="AbiGi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="246" mass="28489" checksum="FEACF05B8083BBD1" modified="2016-06-08" version="1">MIVTTIAEMLHRRNDLSTFLVHFTKPSDDDESGFDALKSILWNWRIEARTPYGAARNHPWAADSQRVVCFTETPLEHSWTMTRELAERRTANFGPYGVAFTKTHARREGCNPVWYVNHTRGTDWPTLAIDDAVSRETRPYSDRQSIFRVTPFIEQMGDWSGPEGVNRKEFWWEREWRHVGNFTVRPQNTVAVLAPSRDHRELMNYLAEDSTWKARNVPILDPEWGLERMIAVMSGVNPSDLGPFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBR9</accession>
    <name>A0A132PBR9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859408.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22260"/>
    <dbReference type="EnsemblBacteria" id="KWX19697">
        <property type="protein sequence ID" value="KWX19697"/>
        <property type="gene ID" value="AFM11_34695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5286"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="289"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="376" mass="39623" checksum="15771B3F024B9875" modified="2016-06-08" version="1">MSLSIAIIGAGLGGLVLARSLHHRGISATVYDAEASSSARSQGGLLDIHPPTGQAALHDAGLYNAFRSLIRSGHDAKRVTDRDGTIVFDWPGSSFGARPEVDRGELRNMLITALPAGMIHWGHKATGVLAVPGQRPKVRFAAGSSVTADIVVGADGAWSRVRRSVSGVEPAYTGTCFIEIGSPPGQLPSHESAQIIGRGTLMAVAPGLGILAHHNADGTLSGYVAVNATLEQIASLDNCGQAAMRAVLAQRFERWAPALVTLVLENLGGPRLRPIYALPIAHRWNRVPGVTLIGDAAHLMSPFAGEGANLAMFDGAALARQIAVQRDDVESALSTYEHALFPRSAEVAQRSADNLRNFFGPDAPRSTVDLFVDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBV2</accession>
    <name>A0A132PBV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TspO and MBR s</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_34065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859107.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02515"/>
    <dbReference type="EnsemblBacteria" id="KWX19798">
        <property type="protein sequence ID" value="KWX19798"/>
        <property type="gene ID" value="AFM11_34065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5150"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PTHR10057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453003" evidence="7">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX19798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="173" mass="18745" checksum="EDB38ECA24D99AC9" modified="2016-06-08" version="1">MRPNTLVKTASAALATALVGGLASRPAESSWYAALRKPSFQPPRQAFPIVWPILYTDIAAVSASTLEKMRAENRSDQARAFTAALGANLVMNAGWSWIFFSQRRLGTAAVAAAALTVSSADLTRRAVRAQGPRAAVLAPYPLWCAFATALSTRIWMLNRGRQRLHPPQLNGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBX3</accession>
    <name>A0A132PBX3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858845.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08040"/>
    <dbReference type="EnsemblBacteria" id="KWX19816">
        <property type="protein sequence ID" value="KWX19816"/>
        <property type="gene ID" value="AFM11_33715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5079"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="227" mass="24466" checksum="6F147E6FCD737F4C" modified="2016-06-08" version="1">MLAVLWDMDGTLVDSEKLWDISMHALYARMGAVLTPEVRESTVGGSAETVMRIVYDDIGLDPDPVAMAESADWLHDYTGELFEQGLPWRPGAQEMLDSLTAAGIPMALVTNTRRELAERALNSIGRHYFSVTVCGDEVESGKPAPDPYLRAAELLGVSTAHCLAVEDSVTGTTSAEAAGCPVLVVPNDVEVPHGPHRRHVSSLTQLDVAELRAVYHSLNSQAGERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBZ7</accession>
    <name>A0A132PBZ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_33655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858936.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19850">
        <property type="protein sequence ID" value="KWX19850"/>
        <property type="gene ID" value="AFM11_33655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5065"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="25668" checksum="4472F86F3B7228FF" modified="2016-06-08" version="1">MGRDSKADQVYSALRDEILNGRLKPGESLSVLKVAERFGASRTPVRDAFVRLESDGLVSLIDRQGARVSSISIGSVRDLFEMRIMLESRATQQVAQAAASNSDIQRTFGDLIEQFTQVANDEAAVQHRERFYQLTETYDQAIITYARNQQLSRVISEMRPHIARLRIIAHSPERLAQSVHEHLAMCRAIVDADPDAAANACTDHLLCTEKTILDAVLHSTGLAVPVELVATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC54</accession>
    <name>A0A132PC54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cinnamoyl ester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858783.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02155"/>
    <dbReference type="EnsemblBacteria" id="KWX19913">
        <property type="protein sequence ID" value="KWX19913"/>
        <property type="gene ID" value="AFM11_33595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5052"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="126" mass="13918" checksum="C6C04BC82561AA2E" modified="2016-06-08" version="1">MATICPTGRHDEHNVYAEACPCRALLDLLANKWSALTIGLLEQGPARFTELHAALPGVGPKMLTQTLRRLEAASLLQRTVYAEVPPRVEYALTELGRDVAEPLGRLRTWAEDNIDRIAALNANWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC74</accession>
    <name>A0A132PC74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858484.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17145"/>
    <dbReference type="EnsemblBacteria" id="KWX19930">
        <property type="protein sequence ID" value="KWX19930"/>
        <property type="gene ID" value="AFM11_33080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4948"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="104"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="261" mass="27856" checksum="E7BFB3FBFEF57512" modified="2016-06-08" version="1">MLSDEVRAQLAADLAQAERSRVPIAPLTDGNPGIDVVDAYEIQLINIRQRVAEGARVIGHKVGLSSKAMQDMMGVDEPDYGHLLDEMQVYEDKPVKSSNYLYPRVEVEVGFILADDLPGAGCTEEDVLAATAAFAPAIELIDTRITNWQIKLCDTIADNASSAGWVLGEARVSPKDVDIRNIDAVLTNHGEVVAEGRSDAVLGNPVTAVAWLARKVEGFGVRLKAGDIVLPGSCTRAIDAPPGSDFVADFAGLGSVRLSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCD3</accession>
    <name>A0A132PCD3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">AFM11_34880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859513.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11020"/>
    <dbReference type="EnsemblBacteria" id="KWX19642">
        <property type="protein sequence ID" value="KWX19642"/>
        <property type="gene ID" value="AFM11_34880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5325"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="9"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX19642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="422" mass="45103" checksum="7C4CA1FD2236A4C1" modified="2016-06-08" version="1">MSVLNDPLVEFDPEIAEAIDLELQRQRVGLEMIASENHAPLAVMQAQGSVLTNKYAEGYPGRRYYGGCEHIDVIERLAIGRVKELFGAEFANVQPHSGAQANAAVMHALIKPGDTILGLSLDCGGHLTHGMRLNFSGKLYNVAAYGVSPSDYLIDMDEVARIARVCKPQLIIGGWSAYPRQLDFARFREIADEVGAYLMVDMAHFAGLVAAGLYPSPVPHAHVVTSTTHKTLGGPRGGIILTNEAELAKKLNSAVFPGQQGGPLEHVIAAKAVGFKMAAQPEFAERQQRVLRGARILADRLSQPDAKEAGITVLTGGTDVHLVLVDLRDAAIDGQQAEDRLDAIGITVNRNAVPFDPRPPMVTSGLRIGTPALAARGFGDDDFSRVADLIVRALVAAPGADVSDLAAEVRALADKYPLYPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCE3</accession>
    <name>A0A132PCE3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858361.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32370"/>
    <dbReference type="EnsemblBacteria" id="KWX20011">
        <property type="protein sequence ID" value="KWX20011"/>
        <property type="gene ID" value="AFM11_32925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4914"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="66"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="472"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="568" mass="60852" checksum="8B8685DF9239DA11" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCL0</accession>
    <name>A0A132PCL0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858076.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19535"/>
    <dbReference type="EnsemblBacteria" id="KWX20068">
        <property type="protein sequence ID" value="KWX20068"/>
        <property type="gene ID" value="AFM11_32410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4810"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="280" mass="29284" checksum="94E8F6974D7C08BB" modified="2016-06-08" version="1">MSSQQESFTDRTLVVSGGSRGIGKAIALGAARRGANVVLLAKTAEPHPKLPGTVHTAVADVEAAGGKAVAVVGDVRKEEDVARAVDTAVDHFGGVDIVVNNASAIATEPTETLSVKKFDLMMDINVRGTFLLTKAALPHLKKSTNAHVLTLAPPLNMNPYWLGAHPSYTLSKYGMTLLSLGWAAEYPGIGFSCLWPETYIATAAVTNLAEGDKMASRSRDPEIMADAAVEILSRPAAEVTGQTFIDSEVLNAAGATDLSRYGGGDDPIIDIFIDAPGQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCX2</accession>
    <name>A0A132PCX2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Disulfide bond formation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_32100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857891.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20183">
        <property type="protein sequence ID" value="KWX20183"/>
        <property type="gene ID" value="AFM11_32100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4746"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="39"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="247" mass="26300" checksum="549C3CEEDE4E50FA" modified="2016-06-08" version="1">MSARRDSVSKDLIFIGGLVVIAVALIRYLVLGSDHDAEAGAGAAASETSAVTDSGTVAPSEQNAKTGVERRQPGDPFALGAPDAPVALVMFSDYRCPFCAKFSRDTELELIERFVDSGKLRIEWRDFPIFGEQSMLAARAGRAAAAQGRFWEFNRAVYAAAPERTKSELTEPALIDFAGKAGVPDIDKFINGMRGSTFDAAINADLAQGTSIGVPSTPAFLINNVPLLGAQPTDEFVRAIENAMTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD75</accession>
    <name>A0A132PD75_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Sulfate adenylyltransferase subunit 1</fullName>
                <ecNumber evidence="12">2.7.7.4</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">ATP-sulfurylase large subunit</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="12">Sulfate adenylate transferase</fullName>
                <shortName evidence="12">SAT</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">Adenylyl-sulfate kinase</fullName>
                <ecNumber evidence="13">2.7.1.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">APS kinase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="13">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="13">Adenosine-5'-phosphosulfate kinase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysC</name>
        <name evidence="12" type="synonym">cysN</name>
        <name evidence="15" type="ORF">AFM11_33610</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">APS kinase catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="function">
        <text evidence="12">With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer composed of CysD, the smaller subunit, and CysN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="12"/>
    <dbReference type="EC" id="2.7.1.25" evidence="13"/>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858805.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02140"/>
    <dbReference type="EnsemblBacteria" id="KWX19922">
        <property type="protein sequence ID" value="KWX19922"/>
        <property type="gene ID" value="AFM11_33610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5055"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00062">
        <property type="entry name" value="Sulf_adenylyltr_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="5"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="455"/>
            <end position="462"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX19922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="619" mass="68194" checksum="36A7C47B98098579" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD89</accession>
    <name>A0A132PD89_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857628.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26285"/>
    <dbReference type="EnsemblBacteria" id="KWX20290">
        <property type="protein sequence ID" value="KWX20290"/>
        <property type="gene ID" value="AFM11_31665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4237"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="496" mass="53063" checksum="ABC37AB4F93BBB15" modified="2016-06-08" version="1">MVDTIDALVRSHAAATPDKAMVIDPHTRLSYAELDSNTRALAAGFLAAGIGKGTRVGLIMPNGADWVQIAIAVARIGAVLVPLSTLLSPAELTAQLRMASVQFLIAVDEFRGRRYPVNRSQLPALREVWTDAEAMALAGADVDLVDALTAAVRPSDSLIIMFTSGSSGPPKGVMHSHANALGAVRSGLDARCITAATRLYLPMPFFWVGGFGAGILSVLLAGATLVTEPIPSPESTLELLQRERVTLFRGWPEQAEALARHADGTDLSALQPGSLEALLPPHLRSRPGARASLFGMTESFGPYCGYPADTDMPRSAWGSCGKPFPGMEVRIVDADTGSSLPAGAVGEIQIRGRHVMRGICRRSREDVFTRDGYYPTGDRGHLDADGFLFYHGRSDDMFKVRGATVYPSEVQRALRGINGVRAAFVTNVPDGESNRVGAAVVSDFSSVEPLRAAAREAMSSFKVPTVWLLLTDEEVVPRGPTGKVDNRRLCAMLMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD91</accession>
    <name>A0A132PD91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857655.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26355"/>
    <dbReference type="EnsemblBacteria" id="KWX20299">
        <property type="protein sequence ID" value="KWX20299"/>
        <property type="gene ID" value="AFM11_31730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4250"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="100"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="415" mass="46489" checksum="D9F2C0294C5963EF" modified="2016-06-08" version="1">MTDTPERLPYLAVDVDNHYYEPLDAFTRHLPKEFRSRGVQMVQDGKRTLAVMGGTVNHFIPNPTFDPIIEPGCLDLLFRGEIPEGVDPASLMKVDRLSDHPEYQNRDARLEVLDRQRLETVFMLPTFACGVEEGLKHDIEATMASVHAFNLWLDEDWGFDRPDGRFISAPIISLADPVKAVEEVEFVLGRGAKLVCVRPAPVPGQVRPRSLGDPLHDPVWARLAEAGVPVVFHLSDSGYMAVPALWGGSGVFKGFGKRDPLDMVIMDDRAIHDTMASMIVHQVFTRHPKLKVASIENGSYFVYRLIKRLKKAANNAPYHFKEDPVEQLRNNVWIAPYYEDDVKLLADTIGVDKILFGSDWPHGEGLADPTTFTADIPQFPEFSLEDTRKVMRDNALELLGDVTRTAPGVSHLVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDB6</accession>
    <name>A0A132PDB6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_33270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858591.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16955"/>
    <dbReference type="EnsemblBacteria" id="KWX19962">
        <property type="protein sequence ID" value="KWX19962"/>
        <property type="gene ID" value="AFM11_33270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4986"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="183"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="318" mass="33195" checksum="BC14986EFA578E09" modified="2016-06-08" version="1">MNFEIDEQQRDFAASIDAALGSADVPAAVRAWAAGDTAPGRKVWSQLADLGVTALLVAEKFDGIEAHPVDAVVALERLGYWAVPGPVTESIGVAPILLADDERSGALASGELIATVALPPQAPRAIDAHFAGLILAAGDGEVRDGAPGTQHDSVDPARKLFDVDATGDARPADTARAYEFGVLATAAQLVGAGQAMLDQSVEYAKQRSQFGRIIGSYQAIKHKLADVHIAVELARPLVYGAALSLAEGSPDTARDVSAAKVAASDAALLAARSALQTHGAIGFTQEHDLSLLLLRVQALRSAWGDPTLHRRRLLEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDL2</accession>
    <name>A0A132PDL2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_31020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26730"/>
    <dbReference type="EnsemblBacteria" id="KWX20426">
        <property type="protein sequence ID" value="KWX20426"/>
        <property type="gene ID" value="AFM11_31020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4107"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="74"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="27115" checksum="F4537A395CB1A540" modified="2016-06-08" version="1">MSIDVEPIGEHLSSLDSGLRVMTMFVNSDSINVTSVARELSCSRSSAYRILNTLRNRGIVILGPTGRGYFPGPVLLDLARPRGLDLDDRTRLLPVLRRAVDLTGETVHVATLVGTQVLFFDGIEPDRPVRATLQQGYLRPAHAISAGKLLLSQLTDDQVRALYPAQQLAKVTPWTIDTVTGLLDELVTIRRTGQAFSRQEAAVGLCGTAVALPGRSWRERVALCATVPHDRGDDAGLLATQAGLLEAAAGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDQ0</accession>
    <name>A0A132PDQ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20459">
        <property type="protein sequence ID" value="KWX20459"/>
        <property type="gene ID" value="AFM11_30245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3946"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="134" mass="14078" checksum="4243C87B5EEE2A10" modified="2016-06-08" version="1">MMEADPDELAIIDAMMGLHAIERTGFPLGFMVGAGYELSGPLVGLGATPVPAMSVEPFFVGLDNITQLVQALGRADWAAAVLDDNSFVLTNNRADTHIPLGAHIPHNCSLLTRAAQNRAKRAVAAAAVDDREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDS3</accession>
    <name>A0A132PDS3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858206.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20112">
        <property type="protein sequence ID" value="KWX20112"/>
        <property type="gene ID" value="AFM11_32310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4791"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="321" mass="36390" checksum="D5C6FFC9BBB7B2EA" modified="2016-06-08" version="1">MAANKSRPKAEEIVLYDKDPTTKIATITLDRADELNAMTTDAQQRYADLVHHASVDDDVKVLVIRANGPNLGSGADLPELLDIMADRGDVTMNHTVRVPDDADVVYPPQGSYRHRATHVQFYTDPAAGMRCLQDFKKISILEVRGYCYGWHFYQAADADIVVASEDSLFGHAAWRYAGFAARQWQWATTMGVRRFMEMVFTGRPFTAKEMYDCDFVNAVVPFDELEAMTEKYALACSRTRPTDTVFVQKTFFEIFKQHQGEYMGSILTGLLESTLDQLQPDPTSFELDEKTRDRGLTNAVRDNDELFPPDWRLSRRGRTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE73</accession>
    <name>A0A132PE73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25025"/>
    <dbReference type="EnsemblBacteria" id="KWX20639">
        <property type="protein sequence ID" value="KWX20639"/>
        <property type="gene ID" value="AFM11_29685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3829"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="27275" checksum="471358B8240C8FF0" modified="2016-06-08" version="1">MPQTPRAHVCVLASLNFPDISAEDVALIRRFTRLALTTLIELGASYELWDTTEALDNPSAAAEFDGLLLLGGGDIDGSCYGVSTPNPKAYGVDARADRDAFAAIAAAEAAERPIFGICRGSQLLNVARGGTIIPDIVDYKLHHGAPGEPEFVDEPIEIVAGTRLASILDAERITGRSGHHQAVDRVGEGLVVAARALDGIVEGIEDPSRFYLGVQWHPEDEYGPEADRLRLFSAFVSAAEQARQGRVAAVASAAVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEF0</accession>
    <name>A0A132PEF0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MCE-family protein MCE3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040657.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20705">
        <property type="protein sequence ID" value="KWX20705"/>
        <property type="gene ID" value="AFM11_29245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3734"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="124"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="465" mass="48917" checksum="956D245265D93DA4" modified="2016-06-08" version="1">MNPRPGENRFHSAWWTLILFVAIAAFVFVTSSTFAGTFRSFVPVTLTSDRAGVVMETGAKVKMRGVQVGRVAQITAGKNSVSLTLEIEPDQIRYIPANVEAQINATTAFGAKFVELIPPEHPSVQRLAAGAVLRSINVATEINTVFENIVDLIGVIDPAKLNAVLTAVAEAVRGQGERIGEATTDLNQVLLALNARSDTLRQDWRSFKSFNDTYSSAAEDIVAVLNAASTTSTTIVDHAEALDALLLNVTGMSTAGINLLGASKDNLVRSVEVLQPTTDLLLQYSPSYACALQGATWYLNNGGYTAWAGADGRSAQFDAALMFGNDPFLYPDNLPIVAAKGGPGGKPGCGSMPDPTKNWPVRQLITNVGWGTGLDWRPNPGIGHPCWVDFFPVTRAVPEPPSIRPCLPGPAPGPVPYPGAPPYGAPLYGPGGTPLWPGVPPPPPPPPTPGTAPTAAIPAPVPPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEQ8</accession>
    <name>A0A132PEQ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Death-on-curing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856179.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32845"/>
    <dbReference type="EnsemblBacteria" id="KWX20793">
        <property type="protein sequence ID" value="KWX20793"/>
        <property type="gene ID" value="AFM11_28590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3598"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006440">
        <property type="entry name" value="Doc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426">
        <property type="entry name" value="PTHR39426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01550">
        <property type="entry name" value="DOC_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="129" mass="14433" checksum="BF5994641C3F21EB" modified="2016-06-08" version="1">MIEYLDLDDLLQIARRAVGEDVKVGDYGLLESALARPRASVFGEDAYPDLHLKAAALMHSLARNDALIDGNKRLAWTACRTFLAINGQWISAPEDDRFDFVIRVATGAESDLDQIAGQLREWSYQDSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PET3</accession>
    <name>A0A132PET3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856963.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00515"/>
    <dbReference type="EnsemblBacteria" id="KWX20502">
        <property type="protein sequence ID" value="KWX20502"/>
        <property type="gene ID" value="AFM11_30510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4002"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="211" mass="23275" checksum="C2A16C2EC9B985E9" modified="2016-06-08" version="1">MTRQWNRNRLKFLVAGPLFEAGNRFIPGKPHERLAQLVVDRHPRRVLELCGGTGYAARLVASGLPTATVDSVDISPEMLAVGRRQLARRHIHTVTLHEGDVAALPFDAHTFDVVMSVFGWHELPTTTRHLAIDETIRVLRPGGHVISIDLDAPPTAAHFFDIYLRLAEPRHAREVLGTGLVDAFAAHGLTVSEHKPANGWAAPFQTVHAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-12-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFA3</accession>
    <name>A0A132PFA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855197.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21015">
        <property type="protein sequence ID" value="KWX21015"/>
        <property type="gene ID" value="AFM11_26875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3248"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="78" mass="8919" checksum="BF410C12D1045958" modified="2016-06-08" version="1">MARDDAPAPTGGAKRRFTLRYWVVLILVGLAAIFVAQNRDRVAIHVLWVTVESPMWFILVIIFVVGLFIGLLLRRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFA9</accession>
    <name>A0A132PFA9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">katG</name>
        <name evidence="12" type="ORF">AFM11_27805</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855713.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10335"/>
    <dbReference type="EnsemblBacteria" id="KWX20897">
        <property type="protein sequence ID" value="KWX20897"/>
        <property type="gene ID" value="AFM11_27805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3435"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="147"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-113)" evidence="8">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX20897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="748" mass="81905" checksum="3FE1A0C575A9D797" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFD6</accession>
    <name>A0A132PFD6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ATP:glutamine synthetase adenylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">ATase</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Glutamine synthetase adenylyl-L-tyrosine phosphorylase</fullName>
                <ecNumber evidence="3">2.7.7.89</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Adenylyl removase</fullName>
                <shortName evidence="3">AR</shortName>
                <shortName evidence="3">AT-N</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Glutamine synthetase adenylyl transferase</fullName>
                <ecNumber evidence="3">2.7.7.42</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Adenylyl transferase</fullName>
                <shortName evidence="3">AT</shortName>
                <shortName evidence="3">AT-C</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">glnE</name>
        <name evidence="6" type="ORF">AFM11_27150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[glutamine synthetase]-L-tyrosine + ATP = [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18589"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP</text>
            <dbReference type="Rhea" id="RHEA:43716"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.7.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GlnE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.89" evidence="3"/>
    <dbReference type="EC" id="2.7.7.42" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855314.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07000"/>
    <dbReference type="EnsemblBacteria" id="KWX21056">
        <property type="protein sequence ID" value="KWX21056"/>
        <property type="gene ID" value="AFM11_27150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3305"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047388">
        <property type="term" value="F:[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000820">
        <property type="term" value="P:regulation of glutamine family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00802">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GlnE" evidence="4">
        <location>
            <begin position="85"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="5">
        <location>
            <begin position="339"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="GlnE" evidence="4">
        <location>
            <begin position="592"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="5">
        <location>
            <begin position="852"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl removase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl transferase" evidence="3">
        <location>
            <begin position="500"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="996" mass="108040" checksum="2D47393A402C4BFB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFS0</accession>
    <name>A0A132PFS0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855317.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07005"/>
    <dbReference type="EnsemblBacteria" id="KWX21057">
        <property type="protein sequence ID" value="KWX21057"/>
        <property type="gene ID" value="AFM11_27155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3306"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="120"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="209" mass="22429" checksum="6A992FEF318E6A88" modified="2016-06-08" version="1">MDYTFDVISADEHDRLQALYEPLTNAVRDLVDASIRSGVDDDSIGRATAAIEAVTETLRREQRDGPQAMRHAETGRPVVWANPVVGLRNALAPPLVINHESDGTCWSEFTLGAAYEGPTGWVHGGICALVLDHILGEVASGGLNKPLYTGTITCRYVRGTPLGELRADAFVERTEGVKTLARGRLSDADGVTVEAEGVFIMPAWARSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG53</accession>
    <name>A0A132PG53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855093.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22555"/>
    <dbReference type="EnsemblBacteria" id="KWX21254">
        <property type="protein sequence ID" value="KWX21254"/>
        <property type="gene ID" value="AFM11_26780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3227"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="472" mass="49086" checksum="F83949DAE8193A51" modified="2016-06-08" version="1">MGTAVVVGGGPNGLAAAITLAVNGVEVTVLEAADTVGGGVRSSEGIVPGLIHDDCAAIHPMAVGSAFLTGLDLEHHGLRWRWPDIDCAHPLDGGDAGLLYRSVDDTAAGLGSDGARWRMLFGGPSARFDTLADDIMGPLLRIPKHPLALARFGAPTLLPAAVFARAFRTPQARALFGGVAAHTFRPLHYPMTSAIGLGIITAGHRHGWAVAEGGSQSITDALAAALADAGGKVQTGVRVASAADLPSADITMFDLTPTAVADILGDRLPRRIARGYRRFRYGPGAFKVDFAVEGPVPWTNPNVGGAGTVHLGGDIDEITATERDIHAGRMPQRPFVLVGQQYVADPGRSAGDVNPVYAYAHVPHGYTGDATDAIIAQFERFAPGFRERIVGTAVRSTTEMSVYNANYVGGDICTGAKDVRQLVFGPYPTLSPYSVGIPGTYICSAATPPGPGAHGMCGANAATQALKYLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGE9</accession>
    <name>A0A132PGE9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853972.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26980"/>
    <dbReference type="EnsemblBacteria" id="KWX21428">
        <property type="protein sequence ID" value="KWX21428"/>
        <property type="gene ID" value="AFM11_24725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2306"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="363" mass="39918" checksum="6E40AE9D09C1044F" modified="2016-06-08" version="1">MDLKWWPVIIAGVVCLLAAVAAAALLPMAKVERVLRPLAHVDRLTRLPEYARVYRIYFLSMIITGVLLLATFAAALTASARPIGASTTTKEFDTEHPEDIMLCVGEPVTDPTTANFLTYYAQQAKSFDTQRIGLTSSSLRVVPLTRDHEYAAQRFEYFAKMARIQQDLDTNRDVSDADRAELQTGIEKFAQSITYVDYARSVEDILALCLTGFPSFEGKSQHRRSLVYIGYSAFRSPDEQRAQLYTEQAIKDMATKAGVQINVISRSDVAESSPEANNRLQSISEATGGKFSLYNPAGTAQTEAGEDATLTRLLDEIRDNPPEVVLSSGRVVTSESWDAPRDALLAAVVAAVLLCVSLAVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH69</accession>
    <name>A0A132PH69_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxy-2-oxovalerate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24085</name>
        <name evidence="3" type="ORF">AWC31_24035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853580.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24035"/>
    <dbReference type="EnsemblBacteria" id="KWX21614">
        <property type="protein sequence ID" value="KWX21614"/>
        <property type="gene ID" value="AFM11_24085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15622">
        <property type="protein sequence ID" value="ORX15622"/>
        <property type="gene ID" value="AWC31_24035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2176"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="12"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="251" mass="26790" checksum="120DEC4A8F5A38B3" modified="2016-06-08" version="1">MPSTVPADRRNAIWLSDPSVAAAEIARGIGYGAVVLDIEHGAFDLADLERFIPFLRHLGMEVLAKVLGPERGPIQQALDFGATTVVIPHIENAAHAKAVTAFAKFPPLGDRSFAGGRTSNYGGFTDDWVREQDTTTRCYPMIEDAGAIEDIAEILALDTVDGVFVGPSDLSLRRDRGAYSREDGDFADLAVIAAAAAEAGKPWVLPAWSKEEKEFAVAHGADQMALMMQHGALAAGFTAPFEQVAAIRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHE2</accession>
    <name>A0A132PHE2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone biosynthesis methyltransferase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24695</name>
        <name evidence="3" type="ORF">AWC31_26950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853958.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21422">
        <property type="protein sequence ID" value="KWX21422"/>
        <property type="gene ID" value="AFM11_24695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14799">
        <property type="protein sequence ID" value="ORX14799"/>
        <property type="gene ID" value="AWC31_26950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2300"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="48"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX14799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="197" mass="21929" checksum="5A5599D036632AF2" modified="2016-06-08" version="1">MDGLARQTRRATGTFPYPHQAAFFLNNPLRRLTGSHDRAARSLELTGSERVLELGPGPGYFSVAIARRLTTGRLDLFDIQPEMLDKARHALDRAGCYNNGFHVGEADAGLPFDDDTFDVAFLAAVIGEVPDKPACLRSLHRVIKPGGLLVFREGFPDPDRLSVNELRDLAESEDFVFQDAGGDRWHDIVRFRRLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHF9</accession>
    <name>A0A132PHF9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_24815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854018.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27070"/>
    <dbReference type="EnsemblBacteria" id="KWX21442">
        <property type="protein sequence ID" value="KWX21442"/>
        <property type="gene ID" value="AFM11_24815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2324"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="170" mass="18321" checksum="F332433165756F80" modified="2016-06-08" version="1">MSNATPTHTLSVLVEDKPGVLARVASLFSRRGYNIQSLAVGATEQKDMSRMTIVVSVGESPLEQITKQLNKLINVIKIVEQEEDNSVARELALIKVRADAGTRGQVIEAVNLFRAKVVDVSTESLTVEATGTPEKLEALLRVLEPYGIRELAQSGVVSVSRGPRGIGTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHM5</accession>
    <name>A0A132PHM5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29910"/>
    <dbReference type="EnsemblBacteria" id="KWX21859">
        <property type="protein sequence ID" value="KWX21859"/>
        <property type="gene ID" value="AFM11_23735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2104"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="194" mass="20463" checksum="1D6A8F12DC0226E9" modified="2016-06-08" version="1">MLSTSGGVVVVGSGPVPRPLRNLPTAGVDEIEAHRRVIVTGPSADLAAVLARLLKADRLDIEVAHARSSWSARRAVNGAAQRVPLIRDETGTVIVSAAEWRGLDGAPLHGEAVVDDAVLFDGDAPGVRIEPTLSQPGLRAAVLSARGRPRGWVSGRAAQLGTTGARVIRDGVPAARQVRRSTFYRHTEGWLRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHX3</accession>
    <name>A0A132PHX3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphonate metabolism PhnG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22270</name>
        <name evidence="2" type="ORF">AWC31_08940</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852671.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08940"/>
    <dbReference type="EnsemblBacteria" id="KWX21903">
        <property type="protein sequence ID" value="KWX21903"/>
        <property type="gene ID" value="AFM11_22270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10268">
        <property type="protein sequence ID" value="ORX10268"/>
        <property type="gene ID" value="AWC31_08940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1804"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019634">
        <property type="term" value="P:organic phosphonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015716">
        <property type="term" value="P:organic phosphonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009609">
        <property type="entry name" value="Phosphonate_metab_PhnG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06754">
        <property type="entry name" value="PhnG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="138" mass="13788" checksum="DB2F5D602841FD07" modified="2016-06-08" version="1">MTAEQRYAALAGADAAELEELADAILATGADISVTAGPESISTPVRVAVPGCAETTVVLGHVALTRCTVELGGTRGDGIRAGHDLTGAVAAAVCDAESHRGGPLAGRVEQLCEAAERDRAARAAARARLVAATGLDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHZ2</accession>
    <name>A0A132PHZ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852782.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08585"/>
    <dbReference type="EnsemblBacteria" id="KWX21956">
        <property type="protein sequence ID" value="KWX21956"/>
        <property type="gene ID" value="AFM11_22620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1874"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="79"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="314" mass="33329" checksum="1BD1B0DA41DB8990" modified="2016-06-08" version="1">MPIDPIAQKMLDDTKASGRPNAHLLPVPTARENFENTFAALAKPEVHRVVDATIETRDGTGIPGRLYLPTGDADLPLTVYYHGGGWLLGSVDSHDVATRLLANASGAAVLSVGYRRGPEARFPTAVDDAIDAVEWARRPSSGLGVDVTRLAVAGDSAGGNLAAAVALHYRDAGDPVVRHQLLVYPVTTTDLGRGMDSAYDGVMLERDELQWHQDNYLPSPDAAGDPRVNVLDADHTGLPEATIILAECDPIRPQGELYEQALRAAGVAVQSHSTPGMVHGFFGLDEVFPTAGAAMTFAGERLAAALSRTDEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI14</accession>
    <name>A0A132PI14_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein AFM11_22225</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852652.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08985"/>
    <dbReference type="EnsemblBacteria" id="KWX21894">
        <property type="protein sequence ID" value="KWX21894"/>
        <property type="gene ID" value="AFM11_22225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1795"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="69" mass="7839" checksum="D90DFFE3179AA9D7" modified="2016-06-08" version="1">MVDDKLLSILVCPQDRGPLLLAGEDRLYNPRLRRAYRIEDGIPVLLVDEAIAIDDDAEHQKLLELAQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI54</accession>
    <name>A0A132PI54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853791.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23575"/>
    <dbReference type="EnsemblBacteria" id="KWX21682">
        <property type="protein sequence ID" value="KWX21682"/>
        <property type="gene ID" value="AFM11_24545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2270"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453373" evidence="4">
        <location>
            <begin position="37"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="406" mass="44187" checksum="FA81BC3B3AA5FDA3" modified="2016-06-08" version="1">MADPSWLTVNRRRLLTGGAAVLAAGAVLTECGAAQSATVGFGGEAEPFHGPHQAGITTAPQSHAVFIAFDVKPDTGRGERDTVAAILRLWTADAARLTRGVPALADTEPELALRPARLTIAVGLGGGLLDRLGLPRPPSARELPVFDTDRLDERWSGGDLVLQICADDPVVVAHATRVLSKNVRSMSVQRWRQTGFRSARGADQQGTSMRNLMGQVDGTATLSPDDFDDLVWLGDDRPALAGGTLMVIRRIEMQLDTWDELDRQSKELTVGRTLDTGAPLTGQREMDEPDFTLRRNGIPVIPENSHIALAHHRDSRERFLRRPYNYDDPPEPGQTSNTGLIFVTYQRDIDAQFLPVQRRLAAFDALNQWTTAIGSAVFVMLPGVDSSEQYLGQALLEEVSRRAGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIH9</accession>
    <name>A0A132PIH9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="6" type="ORF">AFM11_21950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852489.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04755"/>
    <dbReference type="EnsemblBacteria" id="KWX22159">
        <property type="protein sequence ID" value="KWX22159"/>
        <property type="gene ID" value="AFM11_21950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1738"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="96"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="182" mass="19666" checksum="E0BD5110220FB65A" modified="2016-06-08" version="1">MAPDPNLRSADLPSQKQVIELLDGEFARAGYEIDDVVIDAAARPPRITVVADGDEGLDLDSIATLSRRASELLDQLDRGNTPYVLEVTSPGVDRPLTTEKHFRRARGRKADLTLADGTQLTARLGATDGQTLQVVVPDGPRDFAIREIPLGEIAKAVVQVEFSTPNRRELELAGQTGKGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIM8</accession>
    <name>A0A132PIM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein LppU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22145</name>
        <name evidence="2" type="ORF">AWC31_04905</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852558.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04905"/>
    <dbReference type="EnsemblBacteria" id="KWX22195">
        <property type="protein sequence ID" value="KWX22195"/>
        <property type="gene ID" value="AFM11_22145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10627">
        <property type="protein sequence ID" value="ORX10627"/>
        <property type="gene ID" value="AWC31_04905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1777"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="135" mass="14827" checksum="3EB3A1E4B9E62425" modified="2016-06-08" version="1">MQAGDCLKIGGTYDRPEASEAVCGSEQSNYKVVSTVTDSDQCPMDVDSYYSMTSPFSDESETVCMDIDWIVGGCMNIDPENDTDPYRVDCSDSTAPHRQRATEILQGVSNVDQCASGVGYAYDERQFTVCVEDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIY0</accession>
    <name>A0A132PIY0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21880</name>
        <name evidence="3" type="ORF">AWC31_04685</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852469.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04685"/>
    <dbReference type="EnsemblBacteria" id="KWX22147">
        <property type="protein sequence ID" value="KWX22147"/>
        <property type="gene ID" value="AFM11_21880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10587">
        <property type="protein sequence ID" value="ORX10587"/>
        <property type="gene ID" value="AWC31_04685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1724"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="47"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="339" mass="37314" checksum="0EF2964DB9128868" modified="2016-06-08" version="1">MTSREPTWEPDVLPGFWQRTITVGPDPDGEGELVATLVRRGDAAPSAHAVLGLHGYTDYFFHTELADRFAERGFAFYAVDLHKCGRSRREGQTPHFTTDLARYDSELEQALGIIAADTGGARVCMYGHSAGGLIVTLFTDRMRQRGRLATHNIGGLVLNSPFFDLHGPAILRTAPTSAALIALARLRKLYVIRKPTEGGYGTSLHRDYGGEFEYNLDWKPLGGFPVTFGWINAIRRGQARLHRGLDVGVPNLILRSDHSVTETPDPAAIQRGDAVLDVKQIARWAGCVGDHSTITPIVDAKHDVFLSLAEPRAAAYRELDRWLDHYESLQSSSSTTHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJB8</accession>
    <name>A0A132PJB8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19925</name>
        <name evidence="2" type="ORF">AWC31_28590</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000016">
        <property type="protein sequence ID" value="ORX14057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851867.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28590"/>
    <dbReference type="EnsemblBacteria" id="KWX22425">
        <property type="protein sequence ID" value="KWX22425"/>
        <property type="gene ID" value="AFM11_19925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14057">
        <property type="protein sequence ID" value="ORX14057"/>
        <property type="gene ID" value="AWC31_28590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1319"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX14057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="256" mass="27543" checksum="558C77953C96F424" modified="2016-06-08" version="1">MTVLIEDPLIAGMAIKRALPLHESSRRLRELYPECPRVYGVAVMGDLSRRRWWPLAEALSGDRLQLMFDTAIAETDNRAAVAQQLAATLAHVVIGRVVPLLVLEGRAWDTGLENLWVHVDSEGAIDWVGVVDPILRALPDDPHFRAGVTRIADAAHDGIVALPSEAALTTWVAHRSHRALEPLFTRLVEISGGAMSVAAMWHMVGAAVVSAATQVPLLAGCSELVSMRRGQAVLDALVGFGLPVRGASRAGKVLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJM8</accession>
    <name>A0A132PJM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851477.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22450"/>
    <dbReference type="EnsemblBacteria" id="KWX22546">
        <property type="protein sequence ID" value="KWX22546"/>
        <property type="gene ID" value="AFM11_18645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1066"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="55"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="28094" checksum="D7036F1358528992" modified="2016-06-08" version="1">MQTRSGAQITVHGAVVHKLHRPGTDPRTLAARLHVARGLDVFVTPLSLTPERVGDRWRTRWPLMETLAEEPDSVPWADIAQLLARLHNASFARRLPAHGWPARLRRAVARARGYDVIGRAAAGLPDQAWRAGSADRPRTLVHGDFHLGQLGRRAPGPWQLIDVDDLGVGDPAWDLARPAGFWAAGLIPDADWGALVEAYRAAGGPALPSGDPWPVLEPFARAAVIQAAANDPEDEMLSAACARMPQLEKNNRPKPCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJT2</accession>
    <name>A0A132PJT2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22609">
        <property type="protein sequence ID" value="KWX22609"/>
        <property type="gene ID" value="AFM11_19090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1150"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="363" mass="41376" checksum="A4E9A0A02FDFEB8A" modified="2016-06-08" version="1">MANQLLSSLLDMGDDLDEVLAKLQAHATWKWDRYEGFRVGRRFLESLARWLQQFEDIEMRRRWVNFVLNDLIFISAQEIDHAVETAYETELRPFFVRRAAALLEVAPHRTATITASTQFKEVQRRTLILGLSDGARLDQLRRSNNELSHEQYAPSIHLDNPFQQGLLTKLNDALTRFGSTADRTFSHAVLVDDFYGSGTSLLKRVVDNPKRPVAGKIGKFCGKFVRSMADTPAAQQLFADDFSATILLYAASEQAVTHIRTTLQEVGLSHWELVVMQTISASCRVTDPTLIEDCRWFWDPVLEDDHKGNSHLGYKDCALPLVLHHNAPNNSVCPLWADSAGRPDGKNRHALFPRYERHHQDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJY9</accession>
    <name>A0A132PJY9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_21135</name>
        <name evidence="6" type="ORF">AWC31_06500</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852203.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06500"/>
    <dbReference type="EnsemblBacteria" id="KWX22332">
        <property type="protein sequence ID" value="KWX22332"/>
        <property type="gene ID" value="AFM11_21135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09857">
        <property type="protein sequence ID" value="ORX09857"/>
        <property type="gene ID" value="AWC31_06500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1574"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="218" mass="24334" checksum="1C343AC6A33617BF" modified="2016-06-08" version="1">MSSIGSRHRSLRTETVDELRRLILDGELAPGERLNEFSISERLGVSRFPVREAFRRLEAEGLVESLPRRGVRVVELDQHELEVVREMRVALELIAVRHTVNRFTADEQSRLRRILDEGQRAAEAGDDTQLDELNEEFHAALGEGAGSRFLAETLRAVRNQSHHLVGGKSTAVGSSWDEHAAILRAVLDADAELAMMLMRRHLTNRHANQGGAHPDGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK01</accession>
    <name>A0A132PK01_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_19430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15515"/>
    <dbReference type="EnsemblBacteria" id="KWX22666">
        <property type="protein sequence ID" value="KWX22666"/>
        <property type="gene ID" value="AFM11_19430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="DUF1537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SBD_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="NBD_C" evidence="8">
        <location>
            <begin position="212"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="367" mass="37560" checksum="2CF0DFB7007D88F1" modified="2016-06-08" version="1">MRGSVAVMTAIHVLADDLSGAAEVAGGFLGRESDLLLRLGDGPNSAGVTVVDLNTRTMTESDAMRTVGEALDGLAAGTRVVKKIDSLLRGHIRAEVAVLAERGPVTVAVALPALQRRTAGGVLYVGDTPLHETDAWHAEPTGPPRSVAELFDGLTGVTVRDAVTDADLDEIVEAGGPGVQLVGTAALTAAVARTLPVAATPSIRRRSARAVLTVVGTAAPVAQKQISELDPAGIATVVIDSRALLHDKADPEPVHRALERGAAVVTVGGPVEPAETSAVSRALAAFVAAVQAHTPPDLVLTGGETARAVVDAIGISSLRPVNQIHHGAVVSVAPDGRCVVTRPGSFGDTDSLAAIVRYLTQRNEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK45</accession>
    <name>A0A132PK45_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851788.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15720"/>
    <dbReference type="EnsemblBacteria" id="KWX22705">
        <property type="protein sequence ID" value="KWX22705"/>
        <property type="gene ID" value="AFM11_19655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="146"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="320" mass="34404" checksum="89613582D8BFFDAA" modified="2016-06-08" version="1">MAVTVLGPAPVDPLAPAPRGVWSGNGVRVRRRRGPHRDHAGTVCTPRFCAQRRGGALTVEHDLTPDELSDELAILLTDELGASGVLRGQPDFELVFTGIVRSTVDGGMPAWSRFYRNSLAALESGRAAFAPVHERAMQLTAGSQVLDLGSCFGFFPLRMSRAGFEVTATDLSAPTMDLLSRVSFQLCRPVRTLACDAAHVPIADGAADTVTALHLLEHLSPAAGDAVLAEALRLARRRVIVAVPFEDEPQACYGHVRRFDVAELVRLGERLSHTHPGVRVTVSEHHGGWLVLDQATKRSRARTPNSPIAPPDSCPMPGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK70</accession>
    <name>A0A132PK70_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19645</name>
        <name evidence="6" type="ORF">AWC31_15710</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851786.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15710"/>
    <dbReference type="EnsemblBacteria" id="KWX22703">
        <property type="protein sequence ID" value="KWX22703"/>
        <property type="gene ID" value="AFM11_19645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17863">
        <property type="protein sequence ID" value="ORX17863"/>
        <property type="gene ID" value="AWC31_15710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1262"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX17863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="210" mass="22644" checksum="391CC6841E2014DC" modified="2016-06-08" version="1">MIRLALVDDHAILRQGLRSLLEREQDLIVVGEASSEPEAEAMVAAVKPDVVLLDLKLSAGSDFEGLSLCTKLSAAHPEVGLLVLTTFLDEDLVVRAVHAGARGYVVKDVDTTELVRAIRAISSGDSAFDSRSAAAVVRSLSGRTEPREQLTDREIEVLRLLAAGLSNIKIGEKLFISATTAKFHVSNIMRKLDVSRRAEAVYAASKRGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKG8</accession>
    <name>A0A132PKG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyphosphate glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18005</name>
        <name evidence="3" type="ORF">AWC31_12075</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851224.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12075"/>
    <dbReference type="EnsemblBacteria" id="KWX22828">
        <property type="protein sequence ID" value="KWX22828"/>
        <property type="gene ID" value="AFM11_18005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18725">
        <property type="protein sequence ID" value="ORX18725"/>
        <property type="gene ID" value="AWC31_12075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.957"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="269" mass="27902" checksum="B171BE4EEFB70CCC" modified="2016-06-08" version="1">MTAPESTAADPTTDGDPGRRAFGVDVGGSGVKGGIVDLDTGQLIGERFKLETPQPATPEAVTKTVVSVVREFGWTGKVGVTYPGVVTEGIVRTAANVDKGWIGVNAAEVISKALDGQQVTVLNDADAAGLAEEKHGAGRDNTGVIVLLTFGTGIGSAVIHNGVLLPNTEFGHLEVGGKEAEHRAASSVKERKDWSYERWSEEVTKVLIAIENAIWPDLFIAGGGISRKADKWLPLLKNRTPVVAAALQNTAGIVGAAMASAVDVTATAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKS8</accession>
    <name>A0A132PKS8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_16370</name>
        <name evidence="7" type="ORF">AWC31_19950</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850603.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19950"/>
    <dbReference type="EnsemblBacteria" id="KWX22955">
        <property type="protein sequence ID" value="KWX22955"/>
        <property type="gene ID" value="AFM11_16370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16335">
        <property type="protein sequence ID" value="ORX16335"/>
        <property type="gene ID" value="AWC31_19950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.622"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="258"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX16335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="381" mass="39593" checksum="75F9247C1847E2D7" modified="2016-06-08" version="1">MAEAVIVEAVRSPVGKRNGGLSGVHPAELSAQVLNGLVSRAGVDPALVDDVIWGCVMQAGEQALDIGRTAVLTAGWPESVPGVTVDRQCGSSQQSVHFAAAGVVAGHYDIVVAGGVESMSRTPMGASLANGGHPYPEAFQGRYSQTPNQGIGAEMIAEQWGFDRATLDQFSLDSHEKAAAAQDSGAFDDQIVAIKDQDGNPVLKDEGIRRGTTLEKMGQLKPAFKEDGVIHAGNSSQISDGSAALLFMSAEKAKELGLKPLARVHTAVLAGADPVIMLTAPIPATQKALKKSGLSIDQIGAFEVNEAFAPVPMAWLKDIGADEKKLNPNGGAIALGHPLGGSGARIMTTLLYHMRDNGIQYGLQTMCEGGGQANATILELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLD3</accession>
    <name>A0A132PLD3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_17010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850831.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01580"/>
    <dbReference type="EnsemblBacteria" id="KWX23064">
        <property type="protein sequence ID" value="KWX23064"/>
        <property type="gene ID" value="AFM11_17010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.755"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="33098" checksum="51E4F0D1CE37E501" modified="2016-06-08" version="1">MTNDSAAVEIRGLSKSFGRTKALDGLNLTVSHGHITGFLGPNGAGKSTTIRVLLGLLRAERGTVRLLGGDPWHDAVALHRRIAYVPGDVTLWPNLTGQQAIDFLCRLRGNGIDTRRRDQLIDRFELDPHKKARTYSKGNRQKVAIVAAFSCNAELYILDEPTSGLDPLMEKAFQQCVHEVAERGAAVLLSSHILAEVEKLCDNVTIIRAGRTVRSGTLAELRHLMRTSVTVRTRSDGRALRDVPYVHDFSADDGQVKFSVDRGDLEFAMEHLTDLGIEDLTVTPASLEDMFLREYQGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLM1</accession>
    <name>A0A132PLM1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851002.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23144">
        <property type="protein sequence ID" value="KWX23144"/>
        <property type="gene ID" value="AFM11_16530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.655"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="31832" checksum="01D721C66CD1B322" modified="2016-06-08" version="1">MPTAEGRRRRLRIALLQLAFDETEDLSKRVHRVTEMVAAQSEADLVVLPELWAHGAFTPHTWGECAEPIDGELVQRLGAAARRGGVFLHGGSVIESASARSDRGGQGRGLWNTSVVFGPDGRMLAFYRKIHRFGFGEGEPLLLEAGESLTTVRLGEATAGLATCYDLRFPELFRALVVDGVELFVVPAAWPAARRADWEMLGQARALENQAFVVQCNNAGEHGGLAMGGSSRIVDPYGRVTASVGDGEQVLIAEIDLGLATEFRRQFPVLDDRRISVNQPRLTPTTVSTGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLQ7</accession>
    <name>A0A132PLQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_15815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850364.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15950"/>
    <dbReference type="EnsemblBacteria" id="KWX23281">
        <property type="protein sequence ID" value="KWX23281"/>
        <property type="gene ID" value="AFM11_15815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7289"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="221" mass="23509" checksum="3356C0ECE176A895" modified="2016-06-08" version="1">MTIRVIVADDQALVRAGFVALLDAQDGIEVVAEAATGARALAAAVELRPDVVLMDIRMPEMDGLAATRAIADDPTLTDVRVVVLTTFELDEYVFEAMRAGASGFLVKHTEPAELVRAVRVVAAGDALLSPSVTRRLVAEFAAHAKSPAAPALPDLTAREREVMTLVAGGLTNSEIGERLFMSPATARTHVSRILTKLGARDRTQLVVLAYESGLVRPGWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLR5</accession>
    <name>A0A132PLR5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15800</name>
        <name evidence="4" type="ORF">AWC31_15965</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850360.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15965"/>
    <dbReference type="EnsemblBacteria" id="KWX23279">
        <property type="protein sequence ID" value="KWX23279"/>
        <property type="gene ID" value="AFM11_15800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17909">
        <property type="protein sequence ID" value="ORX17909"/>
        <property type="gene ID" value="AWC31_15965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7285"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="51"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX17909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="318" mass="33950" checksum="2060076DB997D16B" modified="2016-06-08" version="1">MSAASVVKKTAAVAAGSLVAGVGYASLIERNAFVLREATMPVLAPGSSPLRVLHLSDLHMRPGQRRKQAWLRDLARLEPDLVVNTGDNLAHPKAVPAVVQSLGDLLSVPGLFVFGSNDYFAPRLKNPLNYVTNPQHRVHGEPLPWQDLRAAFTERGWLDLTHTRRDVDVAGLHIAVAGVDDPHLKRDRYDTIAGKANSAANLTLGLTHSPEPRVLDRFAADGYQLVLAGHTHGGQLCLPFYGAIVTNCDLDRSRAKGASRWGANMQLHVSAGIGTSPFAPVRFCCRPEATLLTLVAAPTGGGHVGTRAGQSSPTVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLX2</accession>
    <name>A0A132PLX2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23012">
        <property type="protein sequence ID" value="KWX23012"/>
        <property type="gene ID" value="AFM11_16710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.693"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453445" evidence="2">
        <location>
            <begin position="25"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="473" mass="47732" checksum="5F095538C9F990A4" modified="2016-06-08" version="1">MRPYATAGIAIAGASVIAVTPITAPPPDAQTRSVELSAAVQNLETPDVSAGAMPPELTAAYAFDAIAPIVSNPTPINGALENLVLARKAIAEALGATGSPGLQGVSADTGTQALAPPDLGIVFDPIAQWADIFTTAFGNVAWIGEQWLADPATFLRQALMNQIGYATMVADTMGSVIPTTLSALFDPSYPNGFASGLVKAFELARANDFIGASNALFSGLIGTAFGLFPMADLLQIPVQMSANLNNVLETAASLPISLGFAAISAVGMAFQSTGTSAQAISDALTEGDTAAALSALIAAPGNITDAVLNGGQFGGGLLSNNGIIARLVVDVPRMLADAITPEAASPSKVEPEKTVTLTVEPQAEPEAAAPEAAETVSAESDSADGTDGDDGTDGNKVTPGESTGTPKHRKPTKLSTTLKNISEDVDKTVAKVTDGVKKALGGNKSEPKKNDEKSGADDDAKGDNDSDGSGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM28</accession>
    <name>A0A132PM28_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849671.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09490"/>
    <dbReference type="EnsemblBacteria" id="KWX23401">
        <property type="protein sequence ID" value="KWX23401"/>
        <property type="gene ID" value="AFM11_13980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6899"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="507" mass="52584" checksum="04C8771128D0774B" modified="2016-06-08" version="1">MDFSAFLDGFALVAEPHNLLYCLIGVLIGMIIGVLPGLGPAATIAILLPITYTIDPVSAIIMLAGIYYGAQYGGTITSVLLRLPGEASSVVTVFDGFALAKQGRAGTALGIAAIGSFVGATISIIGLTLLAPVVASVALDFGPPEYAALALLGVLLVATIGSGNKLKALIAGAVGLLLATVGRDSFSGASRFTFDSLQLADGIDFVVVAMGLFGVGEILYNLEQRHGKPHVPAKVGNVWPSRKDLKQSSGAIGRGSIIGFVLGVLPGGGATLSSIVAYATEKKRSKTPERFGRGAVEGVAAPETANNAAATSSFIPLLTIGLPANASMAMLFGALLILGISPGPQLVDEHPDVFWGVINSMYIGNLLLLLLSIPLVGIFVKILRVRPAILAPITALITILGVYTINNSVFDIFLMIVFGVIGYLMKKFGFDPGSMVLAFVLGTIIESSTRRSLLIFDGDPTGFVTRPISGAILAIFVVVALLPVIRQVHRRRSEPAGVEPPASVTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM63</accession>
    <name>A0A132PM63_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849726.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09255"/>
    <dbReference type="EnsemblBacteria" id="KWX23428">
        <property type="protein sequence ID" value="KWX23428"/>
        <property type="gene ID" value="AFM11_14145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6933"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="89"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="25338" checksum="09641FEF83157FDF" modified="2016-06-08" version="1">MDTASSQALRKALDLLIDPPAEPDLSHGYLDLLGTGSDAPKNTGFIQKAWASPLGSMLYDQAQLLNRRIVAASRPPIDWLNIPSGGTALDVGSGPGNITAALARAAGLDGVALGVDISEPMLARAVEAEAGRQVGFLRADAQRLPFRDESFDAVVSLAVLQLIPDPVAALSEMVRVLRPGRRMAVMVPTAGHGAALRFLSRGGARLFAEDELGDVFEDLGLVGVRTKTHGFIQWVRGAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM98</accession>
    <name>A0A132PM98_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="6" type="ORF">AFM11_16085</name>
        <name evidence="7" type="ORF">AWC31_16660</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850458.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16660"/>
    <dbReference type="EnsemblBacteria" id="KWX23327">
        <property type="protein sequence ID" value="KWX23327"/>
        <property type="gene ID" value="AFM11_16085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18030">
        <property type="protein sequence ID" value="ORX18030"/>
        <property type="gene ID" value="AWC31_16660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7342"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX18030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="84" mass="9588" checksum="FE02F1D8E8E4F277" modified="2016-06-08" version="1">MAKKTPRKRTPAIELKKPRRNQLKALGVTHVDYKDVQLLRTFISERGKIRSRRVTGLTPQQQRQVATAIKNAREMALLPVAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMI9</accession>
    <name>A0A132PMI9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849840.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18335"/>
    <dbReference type="EnsemblBacteria" id="KWX23484">
        <property type="protein sequence ID" value="KWX23484"/>
        <property type="gene ID" value="AFM11_14490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7006"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="224" mass="23787" checksum="C84CCF2EFE518CC8" modified="2016-06-08" version="1">MQVLVVDNYDSFVFNLVQYLGQLGVDAQVWRNDDERLSSDAAIAKVTADFDGVLLSPGPGTPERAGASIPLVRACAAARTPLLGVCLGHQAIGVAFGGTVDRAPELLHGKTSVVHHTDDGVLKGLPDPFTATRYHSLTILPDTVPDELEVIARTEGGVIMGVRHVELPIHGVQFHPESILTEGGHRMLANWLGYCGAAPAETLVRQLEDEVARAVAAATTRNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN03</accession>
    <name>A0A132PN03_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_12955</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03240"/>
    <dbReference type="EnsemblBacteria" id="KWX23695">
        <property type="protein sequence ID" value="KWX23695"/>
        <property type="gene ID" value="AFM11_12955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6683"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX23695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="32643" checksum="3078D8465C5F4693" modified="2016-06-08" version="1">MRRLVAQTSLEPRHLVLPMFVADGIDEPRPINSMPGVVQHTRDSLRRAAADAVDSGVGGLMLFGVPRDEDKDATGSAGVDADGILNVALRDLAKDLGDATVLMADTCLDEFTDHGHCGIVDARGRVDNDATNLQYVKLAVAQAESGAHVVGPSGMMDGQVAAIRDGLDAAGHTDVAILAYAAKFASAFYGPFREAVSSSLVGDRRTYQQDPGNIREAVHEIELDLDEGADIVMVKPAMSYLDVVRAAADISPVPVAAYQISGEYSMISAAAANGWIDLQAAALESLVGIRRAGADIVLTYWAAEVAGWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN43</accession>
    <name>A0A132PN43_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13120</name>
        <name evidence="3" type="ORF">AWC31_03405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849238.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03405"/>
    <dbReference type="EnsemblBacteria" id="KWX23723">
        <property type="protein sequence ID" value="KWX23723"/>
        <property type="gene ID" value="AFM11_13120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11182">
        <property type="protein sequence ID" value="ORX11182"/>
        <property type="gene ID" value="AWC31_03405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6717"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="134" mass="14541" checksum="D2F8B8F9DE169834" modified="2016-06-08" version="1">MAQDENLAAVVSNAAQDIGSFIRSQREAAQVSVRQLAEKAGVSNPYLSQIERGLRKPSADVLNQIAKALRVSAEVLYVRAGILEPSEPSEVRDAIVNDVGITERQKQVLLDIYTSFRQQNEAAAGEEPTSDSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNE8</accession>
    <name>A0A132PNE8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849570.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03175"/>
    <dbReference type="EnsemblBacteria" id="KWX23866">
        <property type="protein sequence ID" value="KWX23866"/>
        <property type="gene ID" value="AFM11_12875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6667"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="160" mass="17816" checksum="2101AC8B18AC113F" modified="2016-06-08" version="1">MTPLDQTAPAFVDMAHAIVWASVATVDADGRPRTRILHPIWEWDGTDLFGWVATVPSPVKRAHLAVNPYVSVSYWTTSHDTCSADCLVEWYTDDETCTQVWDKFANGPAPVGYDPRIIPQWSEGPTSPEFAALRLTPYRLRVMPGTVMMQGAGKVLSWHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNI8</accession>
    <name>A0A132PNI8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_11005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848003.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31250"/>
    <dbReference type="EnsemblBacteria" id="KWX23908">
        <property type="protein sequence ID" value="KWX23908"/>
        <property type="gene ID" value="AFM11_11005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6277"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="PTHR10395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="SSF49472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TR_THY" evidence="8">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="107" mass="10993" checksum="02D0D5312941D2F3" modified="2016-06-08" version="1">MTHISTHVLDAVTGRPAVGVAVTLTGADGAVLAQSATDSDGRIADLYSGPVPDTCRLCFDTATYFAAQGVDALYPEVVVAVSITDASAGYHVPLLLAPFAYSTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNM5</accession>
    <name>A0A132PNM5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13125</name>
        <name evidence="3" type="ORF">AWC31_03410</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849586.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03410"/>
    <dbReference type="EnsemblBacteria" id="KWX23874">
        <property type="protein sequence ID" value="KWX23874"/>
        <property type="gene ID" value="AFM11_13125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11183">
        <property type="protein sequence ID" value="ORX11183"/>
        <property type="gene ID" value="AWC31_03410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6718"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="442" mass="49534" checksum="3E3176B4CA4D96F6" modified="2016-06-08" version="1">MAHRFDAENRALPAPRASFAETLAGADSAADAERRRGLRRMKLVALSFLVGATIVFLVCTWAQSNGAPGWVGYVRAAAEAGMVGALADWFAVTALFKHPLGIPIPHTAIIKRKKDQLGEGLGTFVRENFMSPEVVETKLRDAEVAGRVGKWLSDRSHAERVAAETSTVLRVGVEMLRDEDVQHVLDRMIVKRIAEPQWGPPIGRVLASLLAEGRQEALIQLLCDRAFQWSLNAGEVIERVIERDSPTWSPRWVDHLVGDRIHRELMDFTDKVRRNPDHELRRSATRFMFEFADDLQNDEATIQRAENVKEQIMARDEVARAAETAWTAAKRIILESVDDPSSALRTRIADSVMHIGESMRDDAELRDKVDNWIVRAAQHLVSEYGVEITAIITETIERWDADEASRRIELHVGRDLQFIRINGTVVGALAGLVIYSIAQLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNM7</accession>
    <name>A0A132PNM7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="5">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFM11_11250</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848130.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30645"/>
    <dbReference type="EnsemblBacteria" id="KWX23946">
        <property type="protein sequence ID" value="KWX23946"/>
        <property type="gene ID" value="AFM11_11250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6327"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="7 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="16">
        <location>
            <begin position="5"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="17">
        <location>
            <begin position="335"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="15">
        <location>
            <begin position="438"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="14">
        <location>
            <begin position="570"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="13">
        <location>
            <begin position="642"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KWX23946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="859" mass="91501" checksum="F589280A30A8823E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNZ2</accession>
    <name>A0A132PNZ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848485.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10075"/>
    <dbReference type="EnsemblBacteria" id="KWX24058">
        <property type="protein sequence ID" value="KWX24058"/>
        <property type="gene ID" value="AFM11_11895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6458"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="247" mass="25565" checksum="6951B9D06702769C" modified="2016-06-08" version="1">MSRVAVVTGGASGMGESTCHELGRRGFKVGVVDMNEDAAQRVTDDLRAAGCTAMAIGADVTDSRAVDQGFAKVRGELGPVSALVTSAGVFEYSPFLDISDDAWARIIDVNLTGTFYSCRAALPDMIDAKWGRIVMISSSSAQRGSPFAAHYAASKGAVITLTKSLAREYAEYGITVNNIPPSGIETPMQHQSQAAGYLPPNEQIAGNIPLGRLGTGADIAAAVGFLCSEEAAFITGQVLGVNGGAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPY4</accession>
    <name>A0A132PPY4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_10345</name>
        <name evidence="8" type="ORF">AWC31_18780</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX16900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847581.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18780"/>
    <dbReference type="EnsemblBacteria" id="KWX24363">
        <property type="protein sequence ID" value="KWX24363"/>
        <property type="gene ID" value="AFM11_10345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16900">
        <property type="protein sequence ID" value="ORX16900"/>
        <property type="gene ID" value="AWC31_18780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6106"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="69"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="256"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX16900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="406" mass="43830" checksum="180EAF477974334F" modified="2016-06-08" version="1">MGQVQTVARPHRNLFRWAIVAMVPAVMAGLVACGRDEPEGPPPVITDKGTPFGDLLVPRVNASVTDGAVGVTVESPVTVTAENGVLGAVSMTDEDGNPIAGKVSPDGLTWSTTDPLDYNEQYTLNASSLGLGGVANRRLTFETHSPENLTMPYVLPNDGEVVGVGQPLAIRFDENITDRVAAQRAITVKTTPAVEGAFYWLNNREVRWRPAQYWKPGTRVDVTVNTYGVELGDGLFGQGNVETHFTIGDEVIATADDNTKTLTVRRNGEVIKTMPISMGKNSTPTNNGTYIIGDRYEHLVMDSSTYGVPVNSPNGYRTEVDYATQMSYSGIYVHGAPWSVGSQGYSNVSHGCLNVSTSNARWFYENTKRGDIVEVINTVGTVLPGTDGLGDWNIPWEQWRAGNAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQB6</accession>
    <name>A0A132PQB6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family. Enoyl reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847201.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05630"/>
    <dbReference type="EnsemblBacteria" id="KWX24242">
        <property type="protein sequence ID" value="KWX24242"/>
        <property type="gene ID" value="AFM11_09595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5956"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="3">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="416" mass="43773" checksum="79DA79154D9AC842" modified="2016-06-08" version="1">MTQREFDLVLYGATGFAGKLTAEYLARAGGAARIALAGRSERKLEAVRATLGDAAQSWPLVIADANDPATLDAMAARTQVVVTTVGPYTRYGMPLVAACAAAGTDYADLTGETMFIRNSIDLHHKQAVDTGARIVHSCGFDSVPSDLTVYALYRRAAADNAGQLCDTNLVVRSFAGGVSGGTAASMLEVLRTASSDPEARELMNDPYTLSPDRGAEPQLGAQPDVRWRRGAEIAPELAGYWTGAFAMAAPNTRIVRRSNALLDYAYGRKFEYGEQMSVGRSVVAPIAAAVVTGSNAATLGLGGRYFNRLPAGLIERVLPEPGTGPSEKTRENGHYRVETYTTTTSGARYVATMAQRGDPGYKATAVLLGECGLALALDRDKLSDLRGVLTPAAAMGGALLTRLPAADVTLETTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQC4</accession>
    <name>A0A132PQC4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847909.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05785"/>
    <dbReference type="EnsemblBacteria" id="KWX24474">
        <property type="protein sequence ID" value="KWX24474"/>
        <property type="gene ID" value="AFM11_09440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5925"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="208" mass="22642" checksum="AD6AC92BE2542638" modified="2016-06-08" version="1">MQLARDERTEFAEFLDGLTPQQWDSPTLCGDWRVRDVAAHVIGYDALSRGETIRRMAKGLVTRGGANAVGVAEDAGKQPGELIALFRRYAEPRGLTAGFCGRIALADGMIHQQDIRRSLGLPRVIPPDRLRVVLNFAIWAPPLRGALRTRGVRLVATDLDWSWGRGPEVRGPGEAVLMAMAGRGAALTDLDGPGKDRLAGRLSPRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQK9</accession>
    <name>A0A132PQK9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24635"/>
    <dbReference type="EnsemblBacteria" id="KWX24620">
        <property type="protein sequence ID" value="KWX24620"/>
        <property type="gene ID" value="AFM11_08035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5457"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="556" mass="57790" checksum="BD18B96B335B3EB1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQQ1</accession>
    <name>A0A132PQQ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846372.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00155"/>
    <dbReference type="EnsemblBacteria" id="KWX24660">
        <property type="protein sequence ID" value="KWX24660"/>
        <property type="gene ID" value="AFM11_08265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5504"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="49"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="474" mass="52078" checksum="3975BB9A21533171" modified="2016-06-08" version="1">MSGTVFERQLPSQHVVRQALRESELGCFWLADSGAGTQFPAVTRTAHYDLVIVGGGYTGLWSALLAVQRDPGIRVALVEAATIGSAASGRNGGFVEASLTHGEANGRSRWPEEFDTLQRLGHENLDAIEKAVLELGLDCDFERNGVLNVAVEDYQAAELRSRPEHADSTFLDQNAVREQVNSPTYLAGLYSPREAATVHPAKLAAELARVCARSGVEIFENTPVTGLTGARGQAPICVATEVAPLYADRVILATNAFPSLLKRYRYHTVPVYDYVLMTEPLSDAQLDSIGWRGRQGIADMANQFHYYRLSADNRILWGGYDAVYHFGRRIDPRLEDRPETYTRLASHFFTTFPQLEGLKFSHRWAGVIDTSTQFCAFFGGANRGRIAYAAGFTGLGVAATRFAANVLLDKVQGQRTERTELSMVTSKPLPFPPEPLAWLGVTATRWALDRADHRDGKRNLLLRALDAAGLGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQU7</accession>
    <name>A0A132PQU7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846128.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24577">
        <property type="protein sequence ID" value="KWX24577"/>
        <property type="gene ID" value="AFM11_07795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5410"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="318" mass="34408" checksum="93CB4D23B9C7BB3D" modified="2016-06-08" version="1">MTLNQLRAFVEAHRLGSFTAAADALAVAQASISELVRRLEEELDAQLFVRGSRKLALTAAGQELLPYAEQAVHAADGGVHAVRSLGSLGGGTATFGMPRNADYYLLSSLVQTFHMRYPAVRVRLVGQNSAETAAAIQAGEIEAGMLILPIDDEDLTVRPLLRDEVFYVTADPARAAKPVTIQQFSEADLVLYDAHYGWKDPTRRQLAERAQLAGLRLEPMIEIEHVEAALKLAAGKVGDTIASGAVIDSDAFPSGLYTAPFAEPLYDVIALAQHRARPLSNATREFARLAEDTIRELHIESALSGHNEVAPLIARRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR34</accession>
    <name>A0A132PR34_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_07400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24512">
        <property type="protein sequence ID" value="KWX24512"/>
        <property type="gene ID" value="AFM11_07400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5330"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH10" evidence="5">
        <location>
            <begin position="41"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="383" mass="42307" checksum="F9722E000E8FEFE8" modified="2016-06-08" version="1">MVALVVLSTLSGCGNERDGTTTPDATTGASSPHQVQCGVTDPTLAQLAKARGKTVGTAYRSTYAANDPCYHTVALAEFDSLTTEIGTMMNTVQPAPGVFDFREADAVADLATEHHKDFQIHSLIWDPLDQPQWNIVPPTIRALPPQARHQFMVDSVTTIMKRYAGRASTVTVVNEAFDQMGHLQPNTWWDTTHSDQYIFDAFRAARLADPTAQLYYNDHTAETNSDKSNAIYNLVKRLRDTTVDVEIDGQPTTKPLIDGIGFQGHMLGGANQQPNISDIETNLQRFADLGVSIRFTELDVRIPVLNGTATVADLDRQRLVYNMMTQVCLNQPRCTGLTLWGFTDKRSWITDYPDTFSGYGAATPFAIDYRRKPAWTGIADALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR48</accession>
    <name>A0A132PR48_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fcl</name>
        <name evidence="4" type="ORF">AFM11_09220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13150"/>
    <dbReference type="EnsemblBacteria" id="KWX24818">
        <property type="protein sequence ID" value="KWX24818"/>
        <property type="gene ID" value="AFM11_09220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5692"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="29"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="182"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="333" mass="36280" checksum="39DCEB5306FFA5BD" modified="2016-06-08" version="1">MTTSSRSPRSAAVADVHPVDRGSRIYVAGHRGLAGSAIKRAFEAAGFTDIVGVGSDELDLRDRDATFDYIGSVMPDVIVLAAAKVGGIVANNAYPAEFLSDNVRIQVNVMDAARDVKVRRLVFLGSSCIYPKHAPQPIQESALLSGALEPTNDAYAVAKIAGITHLRAVRREYGLNWIAAMPTNLYGPGDNFDPENSHVLPGMIYRFHHAVQQNEDTVVLWGSGRPRREFLHADDLGRAVVQLLDCYDGPDIINVGTGQDLTIRELAHHVAQVVGFSGEIVWDTQRPDGTYQKLLDVSRISALGWAPRVALSDGIRDAYEWFRANVATTRVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR86</accession>
    <name>A0A132PR86_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08605</name>
        <name evidence="3" type="ORF">AWC31_13765</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846531.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13765"/>
    <dbReference type="EnsemblBacteria" id="KWX24717">
        <property type="protein sequence ID" value="KWX24717"/>
        <property type="gene ID" value="AFM11_08605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18375">
        <property type="protein sequence ID" value="ORX18375"/>
        <property type="gene ID" value="AWC31_13765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5572"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041629">
        <property type="entry name" value="SCP_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17844">
        <property type="entry name" value="SCP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP_3" evidence="1">
        <location>
            <begin position="32"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="128" mass="13353" checksum="631BCC5F1EDD8C18" modified="2016-06-08" version="1">MAARRSADPAKTRAAVTAVAGWLRDADSPEPSRTDLAEAVRLTARTLAALAPGASVEVRVPPFVAVQCISGPRHTRGNPPNVVETDPRTWLLLATGLLDVAGAGGAVQMSGSRAAEIAKWLPLVPLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRB3</accession>
    <name>A0A132PRB3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846907.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22085"/>
    <dbReference type="EnsemblBacteria" id="KWX24835">
        <property type="protein sequence ID" value="KWX24835"/>
        <property type="gene ID" value="AFM11_07585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5365"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="405"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="488" mass="52914" checksum="7353FB81C466853C" modified="2016-06-08" version="1">MNLFAVLDQAASRFGDRGALFLGEKQVCTWSQLRDRVLRLATSLQALGDRGARIAVASENRPEIVELMFAIWAAECVYVPINYKLHPREMADIVADSGASQVFASTKIAAGLSLDAPVEVIDSEAYARRFDAEPAAVPVTDPATLAWLFYTSGTTGKSKGAMLSHRNLMAMTVSHLADFDYPDENCSLIHGAPMSHGSGLYVPPYVLRGARQVVPESAIFEPDEFLDLCDHHPGCSAFLAPTMVQRLLATGRARPRNLQTIVYGGGPMYVDSLKKAMAAYGSVFVQLYGQGEAPMTITGLRRADHVDASDAVLGSVGYARSGVEVAVLREDGSPAGIDEIGEIVCRGDVVMSGYWNNPAATAATLKDGWLHTGDMGSFDAHGYLTLRDRSKDVVISGGSNIYPREIEEVLLEHPAVLEAGVVGAPDDEWGEIVVAFIVGSVSAAELDAHLLERIARFKRPKRYEFIDALPKNSYGKVLKRELRERLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRH7</accession>
    <name>A0A132PRH7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ORF">AFM11_05810</name>
        <name evidence="12" type="ORF">AWC31_11670</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000002">
        <property type="protein sequence ID" value="ORX19222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845106.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11670"/>
    <dbReference type="EnsemblBacteria" id="KWX24951">
        <property type="protein sequence ID" value="KWX24951"/>
        <property type="gene ID" value="AFM11_05810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19222">
        <property type="protein sequence ID" value="ORX19222"/>
        <property type="gene ID" value="AWC31_11670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4353"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX24951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX19222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="187" mass="20422" checksum="8B553270785F8381" modified="2016-06-08" version="1">MASTADFKNGLVLQIDGQLWQIVEFQHVKPGKGPAFVRTKLKNVVSGKVVDKTYNAGVKVETATVDRRDATYLYRDGSDFVFMDSEDFNQHPLPESLVGRAAGFLLESLPVQIAFHDGVPLYLELPVSVELEVTHTEPGLQGDRSSAGTKPATMETGAEIQVPLFINTGDKLKVDTRDGSYLGRVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRK2</accession>
    <name>A0A132PRK2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">X-Pro dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_05805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845105.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11665"/>
    <dbReference type="EnsemblBacteria" id="KWX24950">
        <property type="protein sequence ID" value="KWX24950"/>
        <property type="gene ID" value="AFM11_05805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4352"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="3">
        <location>
            <begin position="141"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="376" mass="39327" checksum="FBC5CC80B1E99B69" modified="2016-06-08" version="1">MTISQRRERLRQRLVAADLDAMLVTDLVNVRYLSGFTGSNAALLVRVSDETPVLATDGRYRTQAAHQSPDAELVIERACGPHLAARAAADGVRQLGFESHVVTVDVFAALTKAAGDDVRLVRAAGAVEALREVKDAGEIAMLRLACEAADAALADLIERGGLRPGRTEKEVRRDLESLMLDHGADGPSFETIVATGANSAIPHHRPTDAVLAAGDFVKIDFGAAVEGYHSDMTRTFVLGHAAKWQRDIYDLVATAQRAGREALAAGVVLSSVDAASREVIADAGYAEYFGHGLGHGVGLQIHEAPGINSAAAGTLLAGSAVTVEPGVYLPDRGGVRIEDTLVVPGGESAEGFGSGTGGDTAAPELLTRFPKELAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRM6</accession>
    <name>A0A132PRM6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_08525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846960.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13840"/>
    <dbReference type="EnsemblBacteria" id="KWX24847">
        <property type="protein sequence ID" value="KWX24847"/>
        <property type="gene ID" value="AFM11_08525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5553"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="267" mass="28620" checksum="C5DD33F24D5F5B63" modified="2016-06-08" version="1">MDLLLLTVDPHPESVLPSLSLLAHTVRTAPTEVSSLLEAGSADVAIVDARTDLAAARGLCRLLGTTGTSVPVVAVINEGGLVAVNHEWGLDEILLPSTGPAEIDARLRLLVGRRGGSANQENVGKITLGELVIDEGTYTARLRGRPLDLTYKEFELLKYLAQHAGRVFTRAQLLQEVWGYDFFGGTRTVDVHVRRLRAKLGTEYESLIGTVRNVGYKAVRPSRGRTPAAAGPEDSVDDEGDDGDLDDATYDSTLDVDGPLAGRLPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRV8</accession>
    <name>A0A132PRV8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_06465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845314.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29210"/>
    <dbReference type="EnsemblBacteria" id="KWX25063">
        <property type="protein sequence ID" value="KWX25063"/>
        <property type="gene ID" value="AFM11_06465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4486"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="27662" checksum="4AD50236358CAC11" modified="2016-06-08" version="1">MSVDSPPRTSSWTASLILAGRLLTHWRRHPLVPMQSLLLPALLLVTYYLLVSKSMVRLTGADNLTALVPMCTVAGAMMATIGAGFQIPTERDSGLLSRFWVSPVNRGSFLAGTLLAEAARTLGAGVIILGIGMLLGLRFDGGLPALIAFLLIPVLVAVVFATIVVTVAVSTRSAALLTLLGTAATGMAFCTGGVAPVELFPAWLQPIIQIQPLTPVVDSMRSLAEGEPVGWSLLVCFAWLAVLLAIFGPLAVRGYRAAAESGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS07</accession>
    <name>A0A132PS07_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-threonine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ilvA</name>
        <name evidence="11" type="ORF">AFM11_06745</name>
        <name evidence="12" type="ORF">AWC31_28905</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845439.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28905"/>
    <dbReference type="EnsemblBacteria" id="KWX25113">
        <property type="protein sequence ID" value="KWX25113"/>
        <property type="gene ID" value="AFM11_06745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13809">
        <property type="protein sequence ID" value="ORX13809"/>
        <property type="gene ID" value="AWC31_28905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4548"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011820">
        <property type="entry name" value="IlvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02079">
        <property type="entry name" value="THD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT-like" evidence="10">
        <location>
            <begin position="343"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX25113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX13809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="426" mass="44855" checksum="02B97E1F0180CF5F" modified="2016-06-08" version="1">MTAELSKDSRVAPLTAADIDEAAQRISGVVTRSPLQISERLSEATGATVYLKREDLQAVRSYKVRGAFNLMAQLSADELAAGVVCSSAGNHAQGFAMACRSMKTHGRVYVPAKTPKQKRDRIRYHGREFIELIAVGSTYDLAAAAALDDVARTGATLVPPYDDVRTMAGQGTIAAELLDQLDGEPDLVIVPVGGGGCIAGMTTYLAERTTGTAVLGVEPAGAASMIAALSAGEPVTLEHVDQFVDGAAVARAGALPYAALAAAGNMVSITTVDEGAVCTAMLDLYQNEGIIAEPAGALSVAALLEADIEPGSTVVCLISGGNNDVTRYNEVLERSLVHLGLKHYFLVDFPQEPGALRRFLDEILGPGDDVTLFEYVKRNNRETGEALCGIELSSAADLEGLLARMEASDIHVELLEPGSPTYRYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS53</accession>
    <name>A0A132PS53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_07100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845626.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17615"/>
    <dbReference type="EnsemblBacteria" id="KWX25176">
        <property type="protein sequence ID" value="KWX25176"/>
        <property type="gene ID" value="AFM11_07100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4618"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="36972" checksum="FF0E6A69BB234209" modified="2016-06-08" version="1">MIHQCVDQYVCLADNISFNLEGLRNGFWQLTIDGLSWGAIYALVAVGYTLVFGVLRLINFAHSEIFMLGMFGAYFCLDVILGFTPSGNAYNKGIALTVLYLAIAMLFAMLVSGLAAVGLEFIAYRPLRKRNARALTFLITAIGMSFVLQEFVHFVLPKLLKGYGGSNAQQPITLVQPKTQFTIFGATVSNVTLVIIGAALVFAVLTDIAINRTKFGRGIRAVAQDPTTATLMGVSRERIIMTTFLIGGLLAGAAALLYTLKVPQGIIYSGGFLLGIKAFSAAVLGGIGNLRGALLGGLLLGIMENYGQAVFGTQWRDVVAFVLLVLVLLFRPTGILGESLGKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS73</accession>
    <name>A0A132PS73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_07215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845673.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17500"/>
    <dbReference type="EnsemblBacteria" id="KWX25196">
        <property type="protein sequence ID" value="KWX25196"/>
        <property type="gene ID" value="AFM11_07215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4643"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="7">
        <location>
            <begin position="7"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="6">
        <location>
            <begin position="368"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="580" mass="59449" checksum="134A2C3AFD84876B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSA0</accession>
    <name>A0A132PSA0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Branched chain amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_07095</name>
        <name evidence="6" type="ORF">AWC31_17620</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845625.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17620"/>
    <dbReference type="EnsemblBacteria" id="KWX25175">
        <property type="protein sequence ID" value="KWX25175"/>
        <property type="gene ID" value="AFM11_07095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17512">
        <property type="protein sequence ID" value="ORX17512"/>
        <property type="gene ID" value="AWC31_17620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4617"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453546" evidence="3">
        <location>
            <begin position="35"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="75"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX17512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="403" mass="42029" checksum="CFB0C33596D1B2A4" modified="2016-06-08" version="1">MRSRVARKAFALGSAGVVALAIAGCSQSTPEEEAAQTNLRIVEKVQIDENGAEVKAAEGVAPADPAGDGKATCPPVMIAMMGALNGPDAALGINIKNGVQLAIDKHNAANPGCQVQLKTFDTEGDPQKATGVAPQIVDEPFIIGLVGPAFSGETKATGDVFNQAGLVATTASATNVTLSENGWRTFFRGLANDGVQGPSVANYLKNTLGHKKVCVVDDSTDYGLGLAEAVRQTLGPVADSACNISVKKGDKDFSAAVTQIKGAAPESVFYSGYYSEAAPFVQQLKDGGVETTFVSADGTKDPEFVKQAGESSKGALLSCPCGPATGAFADEYTQKFGQEPGTYSTEGYDLGTILLKGIDSGAITRDALLNYVRNYDGQGVARKYQWTDKGELTTTLIWMYDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSC3</accession>
    <name>A0A132PSC3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trehalose 2-sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the sulfuryl group transfer from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to trehalose, leading to trehalose-2-sulfate (T2S).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-phosphoadenylyl sulfate + alpha,alpha-trehalose = 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:60091"/>
            <dbReference type="EC" id="2.8.2.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Stf0 sulfotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845871.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29045"/>
    <dbReference type="EnsemblBacteria" id="KWX25258">
        <property type="protein sequence ID" value="KWX25258"/>
        <property type="gene ID" value="AFM11_06630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4524"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015124">
        <property type="entry name" value="Stf0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024628">
        <property type="entry name" value="Sulfotransferase_Stf0_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09037">
        <property type="entry name" value="Sulphotransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021497">
        <property type="entry name" value="Sulphotransferase_Stf0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulphotransf" evidence="3">
        <location>
            <begin position="7"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR021497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR021497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="267" mass="29828" checksum="7E9B11F070BD7EAF" modified="2016-06-08" version="1">MAHKPSSYLVLASQRSGSTLLVESLRSTGLAGKPEEFFQYQPWTSRAPQPREWFAGVEDESILRLLDPFDPGTPDLAPAQIWREYVRTVGRTPNGVWGGKLMWNQTPLLLNRAKDLPDRSGDGLRAAIRDVVGEEPLFVHVHRPDVVSQAVSFWRAVQTKVWRGRPEPIRDAHAQYHAGAIAHLVRMLRAQEEGWRSWFAEEGITPIEVAYPVLCSDFTGVAGSIMSALGLDPKLAPGPALERQADRRSDEWANLYRDDASKQGLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSJ7</accession>
    <name>A0A132PSJ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25331">
        <property type="protein sequence ID" value="KWX25331"/>
        <property type="gene ID" value="AFM11_03335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2541"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="267" mass="27759" checksum="A8CA8FEB47A363B9" modified="2016-06-08" version="1">MTECLAGMNVIVAGGGAIGDGMSNGRAAALTYARKGARVLVADQDEASALKTQELVHAEGGECGVFVGDLSVADHVEAMVAHCLQSLGGHIDVLHNNIGIIRVGGPVELDEADWDRVVTVNLKTLYLTAKYVLPVMEKQQSGVITNIGSLAGLRFTGLPMIAYSTTKGAIPAFTRSLALQYAASGIRANCIHPGVIDTPLQTSTNEAYGGGVDAETLRARREATIPAGRYGSPFDVANAAVFLASPEAQYITGTELVVDGGYIQKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSQ3</accession>
    <name>A0A132PSQ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844045.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21660"/>
    <dbReference type="EnsemblBacteria" id="KWX25353">
        <property type="protein sequence ID" value="KWX25353"/>
        <property type="gene ID" value="AFM11_03490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2572"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032371">
        <property type="entry name" value="DUF4873"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16170">
        <property type="entry name" value="DUF4873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4873" evidence="1">
        <location>
            <begin position="329"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="423" mass="47767" checksum="977A0EC414654839" modified="2016-06-08" version="1">MTASVRAANAATRDEFSERLLKGSVKKSYAPIVDIDWDAPLDPDKFYLPPRVVSLYGTPLWDSMSREQQIELSRQELANTLSAGIWFENILNQALLRKMMHQDPTARSTHYELTELGDETRHMVMFGKAIDKIGAKPVRPRLYQRMIINSLPFMFQGSVLWVAALIGEEIFDSLQRQMMDDPDLQPMVQRLMRIHVTEEARHIQFARDGLRKRTPTMPWITRVWVSNLNGVGGLFFRYLFTNKVQYQRVGLDARAARRMARASAHRQKVQIAGFAPLAAFLEEVGLMGRIGRRMWRRSGFLPQDAGHRSKINWRRRIALEPGAEPSMDEDVYDGPAVVHAAEREHAVRVLLTGHLGPIDGRYRWQGSILDGDMPAGAGPVRLTIGSRTVDARITERTAQGTFSIAGVGEPPFPLDDVEITVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSS9</accession>
    <name>A0A132PSS9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_03665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844132.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21490"/>
    <dbReference type="EnsemblBacteria" id="KWX25383">
        <property type="protein sequence ID" value="KWX25383"/>
        <property type="gene ID" value="AFM11_03665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2608"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019674">
        <property type="entry name" value="Lipoprotein_LpqN/LpqT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10738">
        <property type="entry name" value="Lpp-LpqN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="609" mass="64781" checksum="7EE61C4B78FD1801" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSX0</accession>
    <name>A0A132PSX0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04105</name>
        <name evidence="3" type="ORF">AWC31_21050</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844368.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21050"/>
    <dbReference type="EnsemblBacteria" id="KWX25448">
        <property type="protein sequence ID" value="KWX25448"/>
        <property type="gene ID" value="AFM11_04105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16526">
        <property type="protein sequence ID" value="ORX16526"/>
        <property type="gene ID" value="AWC31_21050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2699"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="194" mass="21771" checksum="5A5FE53A06A7F28F" modified="2016-06-08" version="1">MTDDSKLPQVVSATELSNSFLGKLIEVCFVTADHRRTMEGLVRLGIGPWRVYTFDSATVTERTYRGETADYGIKVCFADVGDLAVEIMEPLYGPSIFQEFLDTHGEGIQHIAFDCDEKPWQDRLGEFGRRGFPLVQSGRFVDANAFAFFDTESVTGTVFETYSIPSGFVWPEPEEWYPAPPPPGQAPPVRPQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSZ4</accession>
    <name>A0A132PSZ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_04240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844441.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20915"/>
    <dbReference type="EnsemblBacteria" id="KWX25471">
        <property type="protein sequence ID" value="KWX25471"/>
        <property type="gene ID" value="AFM11_04240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2725"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034474">
        <property type="entry name" value="Methyltransferase_Class_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306">
        <property type="entry name" value="PTHR43306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01100">
        <property type="entry name" value="methyltransferase_(Class_D)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="108"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="521" mass="57487" checksum="616EE8202207285F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT92</accession>
    <name>A0A132PT92_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844468.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25484">
        <property type="protein sequence ID" value="KWX25484"/>
        <property type="gene ID" value="AFM11_04330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2743"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="214"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="322" mass="34539" checksum="FA3BDE1BA4FF8EB8" modified="2016-06-08" version="1">MAIIAVLAFDNALGFEVMLPGFVFGAANSVSGDDHYDIRVVTIGGSSVIAPMHGAVRLETEWDLDAVADADTVVVPGQVGFFSEPADPVRDALREAAARGARMASICVGAFTLAATGLLDGQRATTHWEYAAELARRYPRVEVDASVLFIDNGAVLTSAGASAGLDLCLHMVRRDLGATVAADTARRIVMPPQRDGGQAQFIAHTDPQSPDTLQPVLDWMQANLHRPLTLDDIAAHGAISVRSLTRRFRAEIGTTPLQWLLRARVHRAQQLLETTDLSVDRIAEEAGFGAATTLRYHFARLTHTSPLAYRNSFHHAGAAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTF8</accession>
    <name>A0A132PTF8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844706.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25595">
        <property type="protein sequence ID" value="KWX25595"/>
        <property type="gene ID" value="AFM11_05005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2882"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="371" mass="39394" checksum="91A97A68C18CD0C5" modified="2016-06-08" version="1">MTALEGITWDHPRGYAALAAAQSEDAAPACEIRWSCQPLEGFESAPIAETASHYDLIVLDHPHIGEAIDTAALRPIDEFVDAATLAEWRASTVGASFDSYFADDRQWAVPLDAATQVSVGTPEIAGDIPATWTDAVEFARDVPTSLPLGGPHPFLTLCAIAISEGAAPAATPDCFLPEDVVATAVTTMRQIVGSADGDINPIGLLERMSASSGPQYCPLVYGYVNYALATLDRPLIFADAPRGSAGVGSVLGGTGIAVSARCAPTAELAAHLRWLVASDTQTVFVPRHHGQPSHRAAWESPDLNAEFGGFYHNTRATVDAAWVRPRYDGFIAVQSHGAEHVRQAVRGDMTPGELSERLTTLHHNASRRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTH2</accession>
    <name>A0A132PTH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25497">
        <property type="protein sequence ID" value="KWX25497"/>
        <property type="gene ID" value="AFM11_04435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2763"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="616" mass="65230" checksum="E2AC08A81C8217E7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTR1</accession>
    <name>A0A132PTR1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_04740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20405"/>
    <dbReference type="ESTHER" id="9myco-a0a132ptr1">
        <property type="family name" value="Abhydrolase_9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25710">
        <property type="protein sequence ID" value="KWX25710"/>
        <property type="gene ID" value="AFM11_04740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2829"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027787">
        <property type="entry name" value="Alpha/beta-hydrolase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012037">
        <property type="entry name" value="Alpha/beta-hydrolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027788">
        <property type="entry name" value="Alpha/beta-hydrolase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10081">
        <property type="entry name" value="Abhydrolase_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15420">
        <property type="entry name" value="Abhydrolase_9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007542">
        <property type="entry name" value="UCP007542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_9_N" evidence="3">
        <location>
            <begin position="37"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_9" evidence="2">
        <location>
            <begin position="261"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="558" mass="61315" checksum="AF6C68CE2EEED312" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTS1</accession>
    <name>A0A132PTS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_00100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842059.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33205"/>
    <dbReference type="EnsemblBacteria" id="KWX25741">
        <property type="protein sequence ID" value="KWX25741"/>
        <property type="gene ID" value="AFM11_00100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.20"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="3">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="278" mass="30409" checksum="E75BDA58BC7E9D5A" modified="2016-06-08" version="1">MSTLWRYVRIQAFVLLCGIVGPIFLTIYFVSGAQPMMKWMFWAGLLITAVDVLIALAITAYGSKTAAKNQQLEQQGVLALAQVTGIQETNTRINEQPLVKLDLQISGPGIAPFATQDRVIASVTRLPMITNRRLVAIVDPTTHEYRIDWDRSSLVSGLMPATFTVAEDNTTYDLTGQTEPLMEILQILKAHNIGMNNMIDLRANPAAREQVQAVVRRAAAQKTAAQPAPQAAPAAAPFMAPPEPSTAQRLQELETLRATGAITEAEYTAKRQQIIADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU80</accession>
    <name>A0A132PU80_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rocD</name>
        <name evidence="7" type="ORF">AFM11_00130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842071.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33240"/>
    <dbReference type="EnsemblBacteria" id="KWX25747">
        <property type="protein sequence ID" value="KWX25747"/>
        <property type="gene ID" value="AFM11_00130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.27"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="416" mass="43926" checksum="EBA735EA4240431B" modified="2016-06-08" version="1">MTILDSVDNEAASGAATASAIALDDRHVAHNYSPLPVVAASAEGAWITDVAGRRYLDCLAAYSAVNFGHRNPEIVATAHAQLDRLTLVSRAFHSDRLGPFARALAEMCGKDMVLPMNSGAEAVESGIKVARKWGTDVKHVPAGQSNIVVARNNFHGRTTTIISFSDDETARRGFGPYTPGFRAVPFGDAAALADAIDENTVAVLIEPIQGEAGIVVPPDDFLPRVREICTQRNVLMIADEIQSGLARTGRTFACDHWGVIPDVYLLGKALGGGVVPLSAVVADRDVLGVLHPGEHGSTFGGNPLAAAIGSTVVAMLQRGEFQARSAELGAHLHERLRKLIGHGVLAVRGLGLWAGVDIDPALGTGKQLSMGLAERGVLVKDTHGSTLRFAPPLVVTAEEIDWAVDRFADTLSQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUH9</accession>
    <name>A0A132PUH9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_01780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842914.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34530"/>
    <dbReference type="EnsemblBacteria" id="KWX26008">
        <property type="protein sequence ID" value="KWX26008"/>
        <property type="gene ID" value="AFM11_01780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.366"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="202" mass="21986" checksum="8B4EC5C24EBC72F8" modified="2016-06-08" version="1">MAYEHSDRRSSSPGSSRKRSSSTKIVISGGFGAGKTTFVGAVSEIMPLRTEALVTNVSEGVDELDGTPDKRTTTVAMDFGRITLDEDLVLYLFGTPGQRRFWFMWDDLVRGAIGAIILVDVRRLQDSFAAVDFFEARKLPFIVAVNEFDGAPKHPTQAVRKALAVPDHIPVITVDARDRNSAKAALIAVTEYSLNTLTALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUM4</accession>
    <name>A0A132PUM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_01825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842939.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34605"/>
    <dbReference type="EnsemblBacteria" id="KWX26015">
        <property type="protein sequence ID" value="KWX26015"/>
        <property type="gene ID" value="AFM11_01825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.375"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="217" mass="23818" checksum="800136EAED12EAFE" modified="2016-06-08" version="1">MLPGVQDLARVVAVGLRERKKLDTRRALSDAALTLTFDRGLENVTREDIAKLAGVSLRTFNNYFTGKYEALAYRQIERLRRSIDLLRERPVGEPLWTSIAESVIAPLDDELGDVGGADSAVPTRQQLVEIRKLLMIPEIRDATFRGMFDEWVAAIAERAGTEPSDMYPRLVAAVVRAVGDVAMDEYAAADPPVPFASLLREGFAAVAAGLPEPGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV54</accession>
    <name>A0A132PV54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_02955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843532.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35735"/>
    <dbReference type="EnsemblBacteria" id="KWX26200">
        <property type="protein sequence ID" value="KWX26200"/>
        <property type="gene ID" value="AFM11_02955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.609"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="131"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="238"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX26200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="389" mass="41498" checksum="F592687AA1E5AC17" modified="2016-06-08" version="1">MAGWAGNPSFDLFQLPEEHEELRAAIRALAEKEIAPYAAEVDEQARFPQEALDALNASGFNAVHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSDDLKKKVLPSLASGEAMASYALSEREAGSDAAGMRTRAKADGDDWILNGTKAWITNGGKSSWYTVMAVTDPDKGANGISAFMVHIDDEGFSVGPKERKLGIKGSPTTELYFENCRVPGDRMIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKERKQFGTAISDFQAVQFMLADMAMKLEAARLMVYHAAARAERGEGNLGFISAASKCFASDIAMEVTIDAVQLFGGAGYTADFPVERMMRDAKITQIYEGTNQIQRVVMSRALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV92</accession>
    <name>A0A132PV92_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_01710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26261">
        <property type="protein sequence ID" value="KWX26261"/>
        <property type="gene ID" value="AFM11_01710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.352"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="15"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="146"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="282" mass="29889" checksum="93CC7AD54B704F8F" modified="2016-06-08" version="1">MTGQRSVATVALTGLAPAIWGTTYLVTTEFLPPDRPLLAATVRALPAGIVLLAISRTLPRGIWWWRAMVLGVLNIGAFFYLLFLAAYHLPGGMAALVMSTQPMFVLLLGAVVLKDRIRPVHIATCVLGVVGVALLVLGPSTALDTIGVLAGVIGAMCMAVGIVLTKRWGRPSDVTLLSFTGWQLVFGGIVLLPITLVSETLPELTWGNTVAFLYLSVIGAVVAYALWFRGISRLPAFVVSLLSLISPLCATVLGYVFLGESLQPLQWMGAAVLIAAIVLAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAV6</accession>
    <name>A0A132PAV6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyruvate dehydrogenase E1 component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_35765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000049">
        <property type="protein sequence ID" value="KWX19450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859946.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31645"/>
    <dbReference type="EnsemblBacteria" id="KWX19450">
        <property type="protein sequence ID" value="KWX19450"/>
        <property type="gene ID" value="AFM11_35765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5889"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="12">
        <location>
            <begin position="414"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX19450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="783" mass="84339" checksum="B90B0365672D7E95" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB60</accession>
    <name>A0A132PB60_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000043">
        <property type="protein sequence ID" value="KWX19534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040757.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19534">
        <property type="protein sequence ID" value="KWX19534"/>
        <property type="gene ID" value="AFM11_35385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5808"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="125" mass="12786" checksum="9B8C4E5FE073D6DA" modified="2016-06-08" version="1">MTTNSSDLALTVAVTHRGAGKEAFAHLTRGESLAMIPPLILELSGRISRRAALLEASSIDAAHSSDDLAALAWIQQSLEDVEATIMGLSEVNRRRSAAFHGPAPSSAGSLGPLGSAGAAGIWALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB63</accession>
    <name>A0A132PB63_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 12" type="primary">ureC</name>
        <name evidence="12" type="ORF">AFM11_35610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="5 7">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859844.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02640"/>
    <dbReference type="EnsemblBacteria" id="KWX19497">
        <property type="protein sequence ID" value="KWX19497"/>
        <property type="gene ID" value="AFM11_35610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5858"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="11">
        <location>
            <begin position="134"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 8 9">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="5 7">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5 6">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX19497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="568" mass="60165" checksum="E068E52480F86CCA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBM4</accession>
    <name>A0A132PBM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19718">
        <property type="protein sequence ID" value="KWX19718"/>
        <property type="gene ID" value="AFM11_34310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5204"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="69" mass="7677" checksum="9705A1C916B53D4F" modified="2016-06-08" version="1">MTMRQEATRALYEGSLAQPGDRNPYAGRSLVLAKLWMRGYQRMLSVRINSGPAMQRYVAARAAAQQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBN3</accession>
    <name>A0A132PBN3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859263.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11215"/>
    <dbReference type="EnsemblBacteria" id="KWX19741">
        <property type="protein sequence ID" value="KWX19741"/>
        <property type="gene ID" value="AFM11_34455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5235"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="269" mass="28510" checksum="E3AF93B934564BF3" modified="2016-06-08" version="1">MARRARVDAELVRRGLARSRQQAAELIGAGRVRIDGMPAAKPATAIAVDANIVVTHSDERSWVSRGAHKLIGALDAFGLSVEGRRCLDAGASTGGFTEVLLYRGAAEVVAVDVGYGQLAWSLRSDTRVVVQERTNVRELTADAIGGPVQLIVADLSFISLATVLPALTACAVADADIVPMVKPQFEVGKDRVGAGGVVSDPELRIDAVCTVARKAAELQWHAVDVTASPLPGPSGNVEYFLHLRRETDAPLHGESLERAVRRAVEEGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBR7</accession>
    <name>A0A132PBR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_34175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19744">
        <property type="protein sequence ID" value="KWX19744"/>
        <property type="gene ID" value="AFM11_34175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5172"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="6">
        <location>
            <begin position="332"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="415" mass="43138" checksum="B0C6EDA1BA6CA198" modified="2016-06-08" version="1">MIIALETACGSPVVLARAAAGASGHLSAYRSDDGYEGLGRALSSGPDTVLTELDASGLRGRGGAAYPTGRKWRAAHTQPPGPRVVVVNADEGDPGAYIDRILLERDPHAVLEGLAIAAVAVGAERAYIYVRREYPHALTAIRAAVAEAEGAGIFGEAVLGYGPPFAVTVVEGKGSYLCGEETALLSALEGRRPTVRARPPYPVEEGLFGLPTVVNNVETLAAVPWILHHGGRAYAAMGTPSSPGTKAVSLNSLFGRPGLYEVEFGMSVRDIVEELGGGFDGDLMGLLIGGPLAGVIPPAQLDVPFTFDDLHRIGAGVGHGGIVGFNQSTPIPELVHHVFRFGAYESCGACTPCRVGAARIEMLFARSMDGASYDEWESTVHALAATSLCGHGSGLADFARSIIAHYGPELASCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBS5</accession>
    <name>A0A132PBS5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33990</name>
        <name evidence="3" type="ORF">AWC31_02440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859009.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02440"/>
    <dbReference type="EnsemblBacteria" id="KWX19766">
        <property type="protein sequence ID" value="KWX19766"/>
        <property type="gene ID" value="AFM11_33990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11021">
        <property type="protein sequence ID" value="ORX11021"/>
        <property type="gene ID" value="AWC31_02440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5135"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="111" mass="11849" checksum="4A3E865DC663E34F" modified="2016-06-08" version="1">MGEASVAGAVRRPVASIHQVLCALQDPVRLEMVRRLHNAGGPVRCAALYDGINKSTATHHFNILRDAGLIEREPADGHTHQRLRTEDVDAAIPGLLDSIVGQANREAGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBT6</accession>
    <name>A0A132PBT6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859098.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19795">
        <property type="protein sequence ID" value="KWX19795"/>
        <property type="gene ID" value="AFM11_34165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5170"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="85" mass="9009" checksum="FB028BB023638AED" modified="2016-06-08" version="1">MARHPGTYTTITPSYALLCVAFGALAAAAYVVAAPDSMPALTGAQCAHYHSDFDERRALLPADSADDWTHPQAVDIPQLGGRCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBV9</accession>
    <name>A0A132PBV9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858938.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08085"/>
    <dbReference type="EnsemblBacteria" id="KWX19809">
        <property type="protein sequence ID" value="KWX19809"/>
        <property type="gene ID" value="AFM11_33670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5070"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="17758" checksum="88A0285E2B58EE11" modified="2016-06-08" version="1">MTVRPIGADEWDLWCQLRIAALTDAPDAFTARLSEWSSIGLPRWRERFATRTAYNLVAERANQPIGLVSGLIVSADECQLRSLWVNPIARGSGAAGLLVEAIIEWARQHGATELTLRVIAHNTRAIDFYRRHGFVEAGDGGGDPVDRSPRELAMARPIRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC55</accession>
    <name>A0A132PC55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33580</name>
        <name evidence="2" type="ORF">AWC31_02170</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858774.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02170"/>
    <dbReference type="EnsemblBacteria" id="KWX19910">
        <property type="protein sequence ID" value="KWX19910"/>
        <property type="gene ID" value="AFM11_33580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13349">
        <property type="protein sequence ID" value="ORX13349"/>
        <property type="gene ID" value="AWC31_02170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5049"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX13349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="156" mass="16676" checksum="351A3CA8B81E1E1D" modified="2016-06-08" version="1">MRMSAKAEYAVRAMVQLAAVGDGDLVKTDDLAKAQGIPSQFLVDILSDLRTDRLVRSHRGRDGGYELARAAEEISIADVLRCIDGPLASVRDIGLGDLPYSGPTAALTDVWRALRASMRSVLEETSLADVACGKLPSHVAKLAGAYLSQEEQRGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCD7</accession>
    <name>A0A132PCD7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_32785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858297.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32160"/>
    <dbReference type="EnsemblBacteria" id="KWX19989">
        <property type="protein sequence ID" value="KWX19989"/>
        <property type="gene ID" value="AFM11_32785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4886"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004707">
        <property type="entry name" value="MmpL_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00833">
        <property type="entry name" value="actII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="765"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="818"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="863"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="891"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="54"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="608"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="939"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="939"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX19989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="961" mass="104505" checksum="5261E5D726DE7C92" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCN4</accession>
    <name>A0A132PCN4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_32560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858144.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19695"/>
    <dbReference type="EnsemblBacteria" id="KWX20090">
        <property type="protein sequence ID" value="KWX20090"/>
        <property type="gene ID" value="AFM11_32560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4840"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="61"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="225" mass="24021" checksum="E61F71CD68E1B36C" modified="2016-06-08" version="1">MGLSGSAGFPVAPTPKNKKPPAWKVGGATILTFVALLYVIELADQLSGGRLDRNGIRPLETDGLWGILFAPLLHANWQHLVANTVPALVLGFLVTLAGMSRFVWATAIIWILGGIGTWLIGDVGGCPLPTNHIGASGLIFGWLTFLLVFGWFTRHVWQIVVGIVVLFVYGGILWGAVPVLNTCGGVSWQGHLCGAIAGVVAAYFLAGPERKAREARKRSQPYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD54</accession>
    <name>A0A132PD54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol uptake facilitator, MIP channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_31400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857488.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25555"/>
    <dbReference type="EnsemblBacteria" id="KWX20246">
        <property type="protein sequence ID" value="KWX20246"/>
        <property type="gene ID" value="AFM11_31400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4186"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="PTHR45724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="253" mass="25376" checksum="8077C70B8E28838E" modified="2016-06-08" version="1">MDEPSLIQKLAAEAFGTAFLVFVGVGSVPATIIVNGDAPFTMADLGMISFAFATVVVATIYALGHISGNHINPAVTLGLAVTGQFPWSRVPAYIGAQALGAIAGAAAIIGVLGTAARDAGLGIATYTADISAVQAFFAEFVGTFILVFTVFGVIHRKATAGFAGVAIGLVVFAAIIPVAPTTGASINPARTFGPMLVQQIAGGSVSWNQLPVYLAAEFLAGALAALAYVAISRTRADAPPATAPAPAQTTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDP5</accession>
    <name>A0A132PDP5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20450">
        <property type="protein sequence ID" value="KWX20450"/>
        <property type="gene ID" value="AFM11_30165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3929"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="199" mass="20989" checksum="5CB2B5EA3443748F" modified="2016-06-08" version="1">MAVLAGRVRTMADPTQHRITLSRPLRWLIGLVVCVVVFAVGFGVGRATRIPFSTAWWRDFAGPVATGTAGVFALSAGAMALLGSHLVSSRSHATTMVDIEHRDDAAKASELWTRFEWLVNAASPENPDDVPLIDAVQAAGMVVSIRDAAKAVKDTHLVSMLNVFMGEQQDGLAAAVGLTGDTAPAEPDNGGSSQTEVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDS0</accession>
    <name>A0A132PDS0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856767.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20444">
        <property type="protein sequence ID" value="KWX20444"/>
        <property type="gene ID" value="AFM11_30130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3920"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="178" mass="19104" checksum="6434144272728159" modified="2016-06-08" version="1">MAHTAAHTLARVRHRYQQFIGDPRSVLDRPALADTTDRFAQALADAFDHAVEALAACTSAADPAAAAAALADAQAAEYALDLADQHARRKARHGLYPGATPPLYARKLDLIEEARASLELATQASDSQEARSHRRRAHTLIEAAQVDIPELLEPAWTTLTDDDGLGAHDAPLCSTKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDV8</accession>
    <name>A0A132PDV8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20515">
        <property type="protein sequence ID" value="KWX20515"/>
        <property type="gene ID" value="AFM11_30615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4024"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="72" mass="7856" checksum="09D1B6F5790D6FC7" modified="2016-06-08" version="1">MVLAAHLGVGATLINHWDFRVGVGIALVLAKLVAGVAVHATRRWRNQQSRAVECDEPARGHGRRLWRLGHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDY9</accession>
    <name>A0A132PDY9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00625"/>
    <dbReference type="EnsemblBacteria" id="KWX20540">
        <property type="protein sequence ID" value="KWX20540"/>
        <property type="gene ID" value="AFM11_30635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4028"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="248"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="469" mass="51112" checksum="0309E3CA220BFA70" modified="2016-06-08" version="1">MRAQPDRSDLSPTAAGWTVAKLATATGENPEDLLDYSRTGLLTRTPDGVFTPNALRRTQLIQFARSRGISRHDLAAALAIQGDLLNRFNTAEPADTATHHITHLAREAALDTEVIDELMPIMGWDSIVTGADIAAAHRIAAALRLGMPRGALMQLLRVFSDTADRLADSVLRTFHDYVHEPRRAQGLSGPELLDASEPIAGPLLDMVEPTVVYFHRRALERAHREDFLRHLTEPDTPPAAVPGQEHLTVLFIDLASFTPLTATMGDHVAADVLRTFALAVRSHATHHRGRIIKQIGDEFMLMFTRPGDAVSFGLAIDDFVNTQTQFPALHIGAHTGPVLFREGDYLGATINLAARVASAGTTGQFLITRELHSAATDCPEARFTPLPPKRLKGIPEPVHLVDVRHSAPARADRRTDPVCGMLLDPADVAATTDWHGTTFDFCSHLCHNAFTAQPERFANAAGQSVHHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE06</accession>
    <name>A0A132PE06_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29645</name>
        <name evidence="6" type="ORF">AWC31_24985</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856484.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24985"/>
    <dbReference type="EnsemblBacteria" id="KWX20568">
        <property type="protein sequence ID" value="KWX20568"/>
        <property type="gene ID" value="AFM11_29645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14459">
        <property type="protein sequence ID" value="ORX14459"/>
        <property type="gene ID" value="AWC31_24985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3821"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX14459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="246" mass="26412" checksum="34ABB6E3D636909E" modified="2016-06-08" version="1">MSSLSPLVAPEAPVGRADEIVQRITEAIHLGLLDDGERLPVEVDLAAQFGVAPMTVREALATLREQELVETRRGRSGGSFVRRPAGPPVDQLAARLSAMSASDLRDLFDEHTAIAGQAARLAAERAAPYVVRRLFAFTDQLDSATTLGDRIRADSRFHIEVAVASQSARLARREANLQAEVAGLIWLPIGPPIDVGAYVEELHAIAAAVAAENPLEARRLAEDHVMGQLPRLTSVHLDLTTQESAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE35</accession>
    <name>A0A132PE35_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856579.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25180"/>
    <dbReference type="EnsemblBacteria" id="KWX20599">
        <property type="protein sequence ID" value="KWX20599"/>
        <property type="gene ID" value="AFM11_29840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3860"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="495" mass="56150" checksum="2502FE860717F851" modified="2016-06-08" version="1">MGANEPGDPEYSDVLIIGAGISGLGAAYRIHEKCPGLTYTLLERRARIGGTWDLFRYPGIRSDSDIFTLSYPYEPWTRPENVADGADIREYLTQTAHKHGIDRHIQFNTHVLSADWDSTTDTWTLHTERDGEAKDYRARFVFFGTGYYNYDEPYTPEFPGIGNFRGDVVHPQFWPESLDYTGKRVVVIGSGATAISLIPALAKQAGHVTMLQRSPTYMMSMARIDPMVQAIRKILPRRLSHQVVRFRNAMVHVLMYFFFRKAPKAGRWLIRNRNTAALPPGYPVDVHFKPRYNPWDQRMCLVLDGDLFEHISDGRTEVVTDHIDHVDADGIVLKSGNRIDADVIVTATGLQLQALGGIALRVDGTEVKPTERFVYKEFLLEDVPNMAWCIGYTNASWTLRADMTARAVAKLLAYMGSHGYTHAYPHKGAVPMPEKRTWDLEAGYIQRSEHALPRSGTRRPWHVRHNYILDAIDHRFDRIEESMVFGRAPAAQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEE0</accession>
    <name>A0A132PEE0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_29165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20693">
        <property type="protein sequence ID" value="KWX20693"/>
        <property type="gene ID" value="AFM11_29165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3717"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="441"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="569" mass="60793" checksum="D96CCCCA06B1DAC0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEF7</accession>
    <name>A0A132PEF7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20674">
        <property type="protein sequence ID" value="KWX20674"/>
        <property type="gene ID" value="AFM11_29035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3689"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="111" mass="12573" checksum="488091849F5208B9" modified="2016-06-08" version="1">MRLCCPVCGQGRIDDDMASNKRRRHTPDQIIRKLAEGNKLLGTGQELAEVCRHLEIAESTWHRWVAQYGGMKANEAKRLKELKAENARLKKLVANQALDIDMLKEISAGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEW5</accession>
    <name>A0A132PEW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_27650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855644.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10185"/>
    <dbReference type="EnsemblBacteria" id="KWX20876">
        <property type="protein sequence ID" value="KWX20876"/>
        <property type="gene ID" value="AFM11_27650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3404"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03146">
        <property type="entry name" value="GAT1_Peptidase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="241" mass="25686" checksum="A177AF967BC1A81C" modified="2016-06-08" version="1">MPADTPTILATSGGIGYGRRTRFAFTALTDFAVELSGVTGRAPRLCLLATAMGDDKAVLHYLTEAAQERGFAVSHLSLFPMPNVDDIAAHLLEQDVVWVFGGSVAGLLAMWRLHGVDAVLHAAWQAGVVLTGISAGSICWHTGGTTDSFGPELQPVTNGLGFVPYANGVHYDVEEQRRPLLQRLVGERVLPAAYATDDGAGVLYRGRTFVEAVAENDSAGAYFVEIVDSTVVETALDVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF45</accession>
    <name>A0A132PF45_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Soluble secreted antigen MPT53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855905.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10780"/>
    <dbReference type="EnsemblBacteria" id="KWX20958">
        <property type="protein sequence ID" value="KWX20958"/>
        <property type="gene ID" value="AFM11_28230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3520"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453201" evidence="1">
        <location>
            <begin position="38"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="172" mass="18226" checksum="EF5CB06889F92B76" modified="2016-06-08" version="1">MSMRFPRLRKPFTIGLTGVLSATAVALALMAAPAAVADDRLQFTGTTLSGAPFDGASLAGRPAVLWFWTPWCPFCNAEAPSVSQVAAANPQVAFVGIAARSDVAAMQGFVDKYNLGFPNLNDADGSIWARYNVPWQPAYVFYRSDGSSTFVNNPTSAMSQQELADRVAALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF57</accession>
    <name>A0A132PF57_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10290"/>
    <dbReference type="EnsemblBacteria" id="KWX20979">
        <property type="protein sequence ID" value="KWX20979"/>
        <property type="gene ID" value="AFM11_27760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3425"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="129" mass="14481" checksum="AFD292B8DDF42B6C" modified="2016-06-08" version="1">MPDLMGISHIDLTVSDCDRSADWWQDVFGFVLVNRTKADSFETRSLVHRSGVALTVVTHDGTGAVGAFNERRTGLDHLAFRVVDIDELRRWVAHLENKNVVHTGIIDVGYGPAIVIRDPDNMQLELYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF71</accession>
    <name>A0A132PF71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855920.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10810"/>
    <dbReference type="EnsemblBacteria" id="KWX20963">
        <property type="protein sequence ID" value="KWX20963"/>
        <property type="gene ID" value="AFM11_28260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3526"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="424" mass="46896" checksum="49777677F7D67DA5" modified="2016-06-08" version="1">MGIAPRVNGAAPPDVPLSDINLGSWDFWALDDDIRDGAFTTLRAQAPISFQPAFEQVGFPQGNGHWAVTRHDDVFYASRHPEIFSSAAGITIGDQTPELAEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLALIEGSVRDRARRLVADMVSHNPDGHAELVTELAGPLPLQIICDMMGIPEDDHQRIFHWTNVILGFGDPDLTTDFNEFIAVAMEIGAYATALADERRAVPADDLTTSLVQAEVDGERLTSAEVASFFILLVVAGNETTRNAISHGVLALTRYPDQRDEWWSAYDEVAPTAVEEIVRWASPVSYMRRTVTRDTELGGVPLAAGDKVTIWFGSANRDESKFADPWRFDVRRHPNPHVGFGGGGAHFCLGANLARREITVAFEELHRQLPAIAVTEEPDRLQSAFIHGIKRLPVAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG72</accession>
    <name>A0A132PG72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretion protein EspR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26585</name>
        <name evidence="3" type="ORF">AWC31_22750</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855149.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22750"/>
    <dbReference type="EnsemblBacteria" id="KWX21274">
        <property type="protein sequence ID" value="KWX21274"/>
        <property type="gene ID" value="AFM11_26585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15692">
        <property type="protein sequence ID" value="ORX15692"/>
        <property type="gene ID" value="AWC31_22750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3187"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="132" mass="14814" checksum="39F404AF9E416869" modified="2016-06-08" version="1">MSKTFAARLNRLFDTVYPPGRGPHTSAEVIAALKSEGITMSAPYLSQLRSGNRTNPSAATMAALANFFRIKPAYFTDDEYYEKLDKELTWLASMRDEGVRRIAARTVGLSPEAQQDLAQKVDELRRRENLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG81</accession>
    <name>A0A132PG81_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX21002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856028.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10710"/>
    <dbReference type="EnsemblBacteria" id="KWX21002">
        <property type="protein sequence ID" value="KWX21002"/>
        <property type="gene ID" value="AFM11_28160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3507"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="27963" checksum="9EBE03677F7908A3" modified="2016-06-08" version="1">MTTIAPQTPIGPLMREWRQRRRISQLDLAIEADVSARHVSFIETGRSVPSRAMVLRLAEVLDVPLREQNQLLLAAGLAPVYTERTLDDPDMAAVREGVSRVLEAYNPYPCVVIDRGWNLLQANAGAGVMLEGVAQHLLAEPNALRITLHPEGMAPRIRNLAEWRHHLITRLRREVAVSGSAELADLLAEIESYPGGMAPVRDLGGVVVPLELATPDGDTLTFLSTVTTFGTALDLTAAELSIEAFLPADEQTAAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGS1</accession>
    <name>A0A132PGS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase III subunit beta</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">DNA starvation/stationary phase protection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26415</name>
        <name evidence="6" type="ORF">AWC31_22900</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854911.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22900"/>
    <dbReference type="EnsemblBacteria" id="KWX21192">
        <property type="protein sequence ID" value="KWX21192"/>
        <property type="gene ID" value="AFM11_26415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15437">
        <property type="protein sequence ID" value="ORX15437"/>
        <property type="gene ID" value="AWC31_22900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3152"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="4">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX15437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="187" mass="20485" checksum="AE22C4C3D4C33F6D" modified="2016-06-08" version="1">MPSSKNTFTIPGLTDKQGAEVAELLQKQLSTYNDLHLTLKHIHWNVVGPNFIGVHEMIDPQVELVRGYADEVAERIAALGASPKGTPGAIVADRSWDDYSVGRDNVQAHLAALDLVYNGVIEDTRKAIERLEDLDLVSQDVLIDHSAELEKFQWFVRAHLESAGGQLAHEGQPTEKGAAGKARRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGS6</accession>
    <name>A0A132PGS6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="5" type="ORF">AFM11_25220</name>
        <name evidence="6" type="ORF">AWC31_27540</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854213.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27540"/>
    <dbReference type="EnsemblBacteria" id="KWX21513">
        <property type="protein sequence ID" value="KWX21513"/>
        <property type="gene ID" value="AFM11_25220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14902">
        <property type="protein sequence ID" value="ORX14902"/>
        <property type="gene ID" value="AWC31_27540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2405"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="4">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX14902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="173" mass="18127" checksum="77E98F92A7B7A773" modified="2016-06-08" version="1">MDLVVGRVVKAHGISGEVVVEVRTDDPDARFAPGGVLRGRAKGGAERSFTVESVREHGGRLLIRLAGVADRNAADELRGTVFLVDTAELPAIDDPDEFYDHELEGLRVVTVDGAPVGSVTEVLHTAAGELLAVKADGDGREVLVPFVGAIVTSVSRETGTIVIDPPEGLLELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGU3</accession>
    <name>A0A132PGU3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactate 2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_25415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854309.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27775"/>
    <dbReference type="EnsemblBacteria" id="KWX21546">
        <property type="protein sequence ID" value="KWX21546"/>
        <property type="gene ID" value="AFM11_25415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2445"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03332">
        <property type="entry name" value="LMO_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037350">
        <property type="entry name" value="LMO_FMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="313"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="336"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="386" mass="41231" checksum="943464B3DD3BB8F4" modified="2016-06-08" version="1">MAYGDYQLEIYLQGLSGVLPNLPMDYANLEAKAQAAMPPSVWSYVAGGAGDERTQRVNRTAFDRWGLIPRMFNAQRERDLSVDLFGLKLPSPLFMAPIGVLGICGQDGHGDLAGARAAAKTGVPLVLSTLTEDPLEDVAAEFGDTPGFFQLYTPTDRELAASLVQRAEAAGFKGIVVTLDTWVPGWRPRDLSTSNFPQLRGKCLANYTSDPVFRAGLPQPPEENPQATVLRWVSLFGNPLTWDDLPWLRSLTKLPLILKGICHPDDVRRAKDGGVDGIYCSNHGGRQANGGLPAIDCLAGVVEAADGLPVLFDSGIRSGADIVKALALGATAVGVGRPYTFGLALGGVDGIVHVLRSLLAEADLIMAVDGYPILADLTPDTLRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH33</accession>
    <name>A0A132PH33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_24445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853749.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23680"/>
    <dbReference type="EnsemblBacteria" id="KWX21668">
        <property type="protein sequence ID" value="KWX21668"/>
        <property type="gene ID" value="AFM11_24445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2249"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="439" mass="48713" checksum="A50AB7C7552FFB21" modified="2016-06-08" version="1">MLELDDIQHILLTRTPAITGRYEFLSFDTPVGGRAWLAELLDKVQSAADVQATMDTSDRWVTLAFTWTGLRALGVPDESLATFPDEFREGMPARADILGDTGTNAPEHWVGGLAGSDLHAIAILFSRTDEQCRRSIAEHDKLLARTDGVRSLSFLDLNATPPFNYAHDHFGFRDRLSQPVMKGSGEEPTPGSGPALEPGEFILGYPDEDGPVAGLPQPEVLSRNGSYLAYRRLQEHVGAFRDYLRENADTPDKQELLAAKFMGRWRSGAPLVLAPDKDDPELGADPMRNNDYNYKEMDPFGYACPLGSHARRLNPRDTAHYMNRRRMIRRGATYGLALPDDAPDDGVDRGIAAFIICANLIRQFEFAQNVWINDKTFHELGNEHDPICGTQDGALDFTVPQRPIRKVHKGIPAFTTLRGGAYFFLPGINGLRYLAALDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH74</accession>
    <name>A0A132PH74_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF222 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24330"/>
    <dbReference type="EnsemblBacteria" id="KWX21708">
        <property type="protein sequence ID" value="KWX21708"/>
        <property type="gene ID" value="AFM11_23815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2121"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF222" evidence="2">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="168" mass="18506" checksum="C2488DC96104BB9B" modified="2016-06-08" version="1" fragment="single">MSSEPAPFPAEARPVDRLEVLFGEVAQLCGQRNAIDARLVEIVAEIERDELWGATGARSMSALVAWKTGVTPRNADTMMAVARRLDEFPRCAQAMRDGRLSLDQVGVIAERAADGSDAHYAQLAAVATVNQLRTAVKLEPHPDPKPQPEPKREITKDVHDDYTTYRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH94</accession>
    <name>A0A132PH94_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Chorismate mutase</fullName>
            <ecNumber evidence="2 4">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_24170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the Claisen rearrangement of chorismate to prephenate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="2 4"/>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853887.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23945"/>
    <dbReference type="EnsemblBacteria" id="KWX21719">
        <property type="protein sequence ID" value="KWX21719"/>
        <property type="gene ID" value="AFM11_24170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2193"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008240">
        <property type="entry name" value="Chorismate_mutase_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026640">
        <property type="entry name" value="Peripl_chor_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01806">
        <property type="entry name" value="CM_mono2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453279" description="Chorismate mutase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate mutase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR026640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="184" mass="19518" checksum="E168522E6CEA4CC0" modified="2016-06-08" version="1">MRTVAAASAFVALAVAAAPTAAAEPQSPLVPLVDAAAQRLQTADQVAAYKFKTGGPIDDPAREQQVIDSVTAMARSDHIDPAYVGAVFRNQIDATVSVEHTRFAQWKLDPGAAPATAPELADTRKTIDRLNQVMVHEMAAQWDVLGSPACEADVDSAMRSVVTARALDAVYQPALAYATHSYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHQ2</accession>
    <name>A0A132PHQ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminotransferase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29835"/>
    <dbReference type="EnsemblBacteria" id="KWX21888">
        <property type="protein sequence ID" value="KWX21888"/>
        <property type="gene ID" value="AFM11_23810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2120"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="34023" checksum="917AF6B4C8845DA8" modified="2016-06-08" version="1">MQYSDYELDTTSPFAGGVAWIEGEYLPASEAKISIFDTGFGHSDLTYTVAHVWHGNIFRLGDHLDRLLDGARKLRLDPGMSKDELAEITKKCVSLSQLRESFVNLTVTRGYGKRKGEKDLSKLTHQVYIYAIPYLWAFPPSEQIFGTTAIVPRHVRRAGRNTVDPTIKNYQWGDLTAASFEAKDRGARTAILMDADNCVAEGPGFNVVIVKDGKLASPSRNALPGITRKTVFEIADAMGIEAELRDVTSHELYDADELMAVTTAGGVTPINSLDGEPIGDGAPGPLTVAIRDRFWALMDEPSALIEAIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIG6</accession>
    <name>A0A132PIG6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852444.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04615"/>
    <dbReference type="EnsemblBacteria" id="KWX22135">
        <property type="protein sequence ID" value="KWX22135"/>
        <property type="gene ID" value="AFM11_21810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1710"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009377">
        <property type="entry name" value="EutA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06277">
        <property type="entry name" value="EutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012293">
        <property type="entry name" value="EutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="511" mass="54202" checksum="B1C21BD301AB765F" modified="2016-06-08" version="1">MTHDADHHHHDEPDLPLEENPIWQQDNVTLYSVGIDIGSSGTQVAFSRLQLRRRGEDLTSRYVVVSRDTIYESEVHLTPYTDDLQIDAQALGHMLDAAYTEAGQEPRDVDTGVVILTGEALRRRNAERIASVVAERAGDLVCATAGHHMEAMLAAYGSGAALTSHEMGARILNVDIGGGTTKLALIDKGRVVATAAFHVGGRLIAVEGDTVTRIEPGGSMHAAAAGFDLALGNRVSEPELDEIASAMADLVIAAVRGEPAADHLYLTQRIGGAAMDEVDGIIFSGGVAEYVYGAEHRDFGDLGRRLGVALAARIAAGALPASVLPAAERIRATVLGASEYTVQLSGITSFIPSAESTLPRRNLQVARPQYELGETVDPDAVAASISAHLTLFGLLETSADVAVALHWNGAPSYRRLRAFAEGVVTGLGCRRAEGRPLYLMIDGDIALTLGTILRDELAVTNDLLILDGIALRDFDFVDLGRVREPSRTVPVTIKSLVFGADQAAACAPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PII1</accession>
    <name>A0A132PII1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-4 C11-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_22840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852861.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08360"/>
    <dbReference type="EnsemblBacteria" id="KWX21997">
        <property type="protein sequence ID" value="KWX21997"/>
        <property type="gene ID" value="AFM11_22840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1921"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="251" mass="26279" checksum="A3533D06C07FCFE1" modified="2016-06-08" version="1">MTVYFIGAGPGAADLITVRGQRLLSSCSVCLYAGSIMPADLLALCPADAKVVDTGPLNLDQIIDELATADRAGLDVARLHSGDPSIYSALAEQCRRLDALGIEYEIVPGVPAFAAVAAVLGRELTVPGVAQTVTLSRVATLSTAMPEGEDLRTLSRPGATLVLHLAAAQIDAIVPQLIDGGYRPETPCAVVAFASWPEEIVLRGTLADIAEKMHAAQVTRTAVIVIGDVLAAEGFTDSYLYSSGRRRGSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIR0</accession>
    <name>A0A132PIR0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21850</name>
        <name evidence="3" type="ORF">AWC31_04655</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852623.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04655"/>
    <dbReference type="EnsemblBacteria" id="KWX22225">
        <property type="protein sequence ID" value="KWX22225"/>
        <property type="gene ID" value="AFM11_21850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10693">
        <property type="protein sequence ID" value="ORX10693"/>
        <property type="gene ID" value="AWC31_04655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1718"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="100" mass="11125" checksum="37A34FCAAE640D9D" modified="2016-06-08" version="1">MERATSALVDVDTATWARRFDLLSDPNRLEILLVLHRAPGIFVGDLAAALGRSENAVSQALRVLRQQGWVTSTRVGRAVSYRLEDEIVHDLLHRIGARHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIW5</accession>
    <name>A0A132PIW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852101.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06270"/>
    <dbReference type="EnsemblBacteria" id="KWX22286">
        <property type="protein sequence ID" value="KWX22286"/>
        <property type="gene ID" value="AFM11_20855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1510"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="156" mass="17106" checksum="E7311778B4B60F25" modified="2016-06-08" version="1">MPTASTENVIVTDETELGADLLSVVARLNRLATQRTRLPLPWAQARLLSTIEDQGEARISDLALLDHCSQPTMTTQVRRLEDAGLVSRTADPGDARAVLIRITDKGRQTLNQARADRAAAINPRLERLDAGDRQTLADAVQVIRRLLADVAEHPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ08</accession>
    <name>A0A132PJ08_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_21250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852237.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06615"/>
    <dbReference type="EnsemblBacteria" id="KWX22348">
        <property type="protein sequence ID" value="KWX22348"/>
        <property type="gene ID" value="AFM11_21250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1596"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="30949" checksum="0AA919FEA231FA88" modified="2016-06-08" version="1">MTTQTESRVASWRLLLSNPVTTISAVVLLAVIVVALTAQWIIPFGVNDIDVPNALQAPSGSHWFGTDELGRDVFSRVLVAVQASLRVAVVSVALAAVIGVTIGVVAGYRGGWLDTIVMRVVDVMFAFPVLLLALAIVAILGPGITTTMLAIGIVYTPIFARVARASTLGVRVEPFVAVSRTMGTGSSYILTRHILPNIAGPLIVQLSLSLAFAILAEASLSFLGLGIQPPQPSLGRMIFDAQGFVTLAWWMAVFPGAAIFVTVLAFNLFGDGLRDVLDPKQRTLMEARRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ70</accession>
    <name>A0A132PJ70_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851828.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11055"/>
    <dbReference type="EnsemblBacteria" id="KWX22385">
        <property type="protein sequence ID" value="KWX22385"/>
        <property type="gene ID" value="AFM11_19715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1277"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="219" mass="24073" checksum="AB36BBCC22456FC9" modified="2016-06-08" version="1">MSTTQRDLARRLLSAAGHTYAEQARIRMADKPMPLFELLVLCMLASKPIDAGIATQAGRELFRSGLRTPHAVLAAERRDMIRAFGRAHYVRYDESSATRLTDIAATVDDHYRGDLRRLADAADRDTAAARRLLKEFKGIGDTGADIFLREVQDTWTWVRPYFDDRALGAARDLGLPGDPAALQRLAPGKTARLAAALVRASLDDELRAALLQPPAHATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJH9</accession>
    <name>A0A132PJH9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_20120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851905.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29990"/>
    <dbReference type="EnsemblBacteria" id="KWX22463">
        <property type="protein sequence ID" value="KWX22463"/>
        <property type="gene ID" value="AFM11_20120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="107" mass="11235" checksum="979C65CCF9EDA200" modified="2016-06-08" version="1">MWLALAGAILVEVFATLSLRASEGLRRKAWAVPVVAGYATSFYLLWVALSLGVPVGIAYGIWTACGVALVALIAKFVFKDPLTPVMMLGIALIVSGVFTIEVAGATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJT1</accession>
    <name>A0A132PJT1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family. Enoyl reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851593.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22598">
        <property type="protein sequence ID" value="KWX22598"/>
        <property type="gene ID" value="AFM11_19020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1138"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="3">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="4">
        <location>
            <begin position="144"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="405" mass="44056" checksum="B89C26A8A05E5570" modified="2016-06-08" version="1">MRILLVGAGGVGSAFCAIAARRDFFDQIVVCDYDESRARQAVDRVGDARFSAAQVDATSAEAVAELVRRHGITHVMNAVDPRFVMPIFNGALAGGADYLDMAMSLSQRHPDRPYELAGVKLGDDQFAVADDWAAAGRLALVGIGVEPGLSDVFARYAADHLFSEIDELGTRDGSNLVVDGYDFAPSFSIWTTIEECLNPPVVWERDRGWFVTEPFSEPEVFDFPEGIGPVECVNVEHEEVLLMPRWVECKRATFKYGLGSEFIDVLKTLHKLGLDRTEKVRVGSSSGSVEVSPRDVVAACLPNPATLGPQMHGKTCAGLWVTGTGKDGRPRSTYLYHVVDNQWSMAEYGHQCVVWQTAINPVVALELLSTGAWGGAGVLGPEAFDAVPFLDLLKDYGSPWGIKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK17</accession>
    <name>A0A132PK17_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851605.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15165"/>
    <dbReference type="EnsemblBacteria" id="KWX22604">
        <property type="protein sequence ID" value="KWX22604"/>
        <property type="gene ID" value="AFM11_19065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1146"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="200" mass="21203" checksum="0A6D6F7194115CD5" modified="2016-06-08" version="1">MSRIEYVTIETPDPAATDAFHKAAFGRDLPVRTRQSDAPTNGFRGFTLSLVVPQPSTVDAFVGAAIEAGATELKPPKKSFWGYGGVIASPDGTIWTVAASSKKNRGPETRQIDEFVLQLGVADVGTSKQFYVERGLEVAKSYGSKYVQFAGPPITLALFGRRNLAKTAGVSPDGSGSHRIVVAGPAGPFTDPDGFAWETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK29</accession>
    <name>A0A132PK29_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">50S ribosomal protein L21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19610</name>
        <name evidence="2" type="ORF">AWC31_15680</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851780.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15680"/>
    <dbReference type="EnsemblBacteria" id="KWX22698">
        <property type="protein sequence ID" value="KWX22698"/>
        <property type="gene ID" value="AFM11_19610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17859">
        <property type="protein sequence ID" value="ORX17859"/>
        <property type="gene ID" value="AWC31_15680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1255"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="PTHR31757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX17859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="157" mass="18429" checksum="EF914F83BF78282E" modified="2016-06-08" version="1">MSESARPPLPPFTRESAIEKVRLAEDAWNTRDPLRVSLGYTVGSRWRNRAEFATGRDEIVALLTRKWNTELDYRLIKELWAYDGNRIAVRFAYENHDDAGNWYRSYGNENWEFDEHGLMHTRHASINTAPIAEDDRKFFWPLGRRPDDHPGLSDFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKE2</accession>
    <name>A0A132PKE2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_17800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851159.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22801">
        <property type="protein sequence ID" value="KWX22801"/>
        <property type="gene ID" value="AFM11_17800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.915"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="532" mass="58182" checksum="966B876A70019FE0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKL8</accession>
    <name>A0A132PKL8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PknH_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_19575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851820.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15645"/>
    <dbReference type="EnsemblBacteria" id="KWX22737">
        <property type="protein sequence ID" value="KWX22737"/>
        <property type="gene ID" value="AFM11_19575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1248"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026954">
        <property type="entry name" value="PknH-like_Extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038232">
        <property type="entry name" value="PknH-like_Extracell_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14032">
        <property type="entry name" value="PknH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453356" description="PknH_C domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PknH_C" evidence="5">
        <location>
            <begin position="27"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="213" mass="22281" checksum="DF881771BC2D775D" modified="2016-06-08" version="1">MRAVTVGLGVAGLALALAAPAGARPSDPGVVSYAVMPKGSVSNIVGAPMRWEAEFTEPFQGFSVDNPVCNNWADIGLPEVYNDPDLASFNGATTQTAAGDDTHLVKQAVGVFANPDAADRAFHRVIDRTVGCSGQTTAMHLDNFVNEVWTFTGGPASATDADWVKQEAGTDRRCFTTTRKRENVLLQAKVCQSGNGGPAVNVLAGAMQNTLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKM7</accession>
    <name>A0A132PKM7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851392.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12635"/>
    <dbReference type="EnsemblBacteria" id="KWX22900">
        <property type="protein sequence ID" value="KWX22900"/>
        <property type="gene ID" value="AFM11_18610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1059"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34796">
        <property type="entry name" value="PTHR34796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="158" mass="17037" checksum="A487C404E1214C29" modified="2016-06-08" version="1">MAQRDRDESGRPRSARPRDALGRPLPPGSEGVPRIPDDLELEPAETLAYAQDLLNRGLAFNAHEVLEAAWKNGPDDERALWQGLAQLMVGVTHVQRGNVNGAIALLQRAADRLARTGLPAPHSIDAAGLIAYARALIDDLRAGIPIAPTRLRPPLTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKR9</accession>
    <name>A0A132PKR9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22938">
        <property type="protein sequence ID" value="KWX22938"/>
        <property type="gene ID" value="AFM11_18410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1019"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="156" mass="17333" checksum="D5AF3A20B89F4150" modified="2016-06-08" version="1">MGGWVDADEFRCRLRRFDGTERFALNLWTLPPDMDYVEAVRAGLDALEYIQTAGRADALTVEIRKAGGSQWGVDWVRYVVGHPHSGAAEPLDVPIVLPQSTEMIARHEVFGADEAADLFYSYYRDGDIPNSYTLRPVEGFTRTGANIDLRAAAAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKZ9</accession>
    <name>A0A132PKZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidylethanolamine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_16465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850635.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19855"/>
    <dbReference type="EnsemblBacteria" id="KWX22973">
        <property type="protein sequence ID" value="KWX22973"/>
        <property type="gene ID" value="AFM11_16465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.642"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="213" mass="23719" checksum="EFEAEC6F903A71D8" modified="2016-06-08" version="1">MSNADKLVDNPLFARLWKTLSNYEPESVRRLRIENLAGLSGRVLEVGAGTGTNFEYYPSTVDEVVAIEPERRLAEVARRAAANAPVPVTVTGDTAERFASSQPFDAVVCSLVLCSIEEPNSVLRQLFSLLRPGGELRYLEHVAGTGYRARLQRMADATIWPRLLGNCHTHRDTEQTIVDTGFQVRDNRREWAMPPWVPMPVSEFAIGKAVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL71</accession>
    <name>A0A132PL71_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_17165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850885.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23090">
        <property type="protein sequence ID" value="KWX23090"/>
        <property type="gene ID" value="AFM11_17165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.786"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="21"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX23090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="429" mass="42919" checksum="0AB548C6ABBE85D2" modified="2016-06-08" version="1">MASSPDVGQSNSASVPSRLKMILVLGALITLGPLTIDMYLPALPKIGEELSVSSSVAQLTLTGTLVGLALGQLIVGPLSDSLGRRRPLMVGIVLHMAASVLCALAPNIVVLGLARVLQGMGASAAAVVAVAVVGDLFAGSAAATVMSRLMLVLGVAPVLAPSLGAAVLLKGSWHWVFVALVVLAGGLLVMGALALPETLPAPHRRPLKVRGIVATYGELLRDSRFVILVLVAALGMSGLFAYISAAPFVLQGGYGLDQQMFALVFAAGAIALIGATQFNVVLLRRFTPQTITLTALAAASVAGVVFVGLTVARVGGLFGFLVPVLAILAAMGLVIPNAPAVALSRHPDAAGTAAALLGAAQFGLGALVAPLVGALGNGALALSAVMTAGMMIALVALLLVGVRGGGADRDDDSQAGDEELVSEAVAEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL95</accession>
    <name>A0A132PL95_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PhoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_17355</name>
        <name evidence="7" type="ORF">AWC31_01935</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850961.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01935"/>
    <dbReference type="EnsemblBacteria" id="KWX23125">
        <property type="protein sequence ID" value="KWX23125"/>
        <property type="gene ID" value="AFM11_17355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13311">
        <property type="protein sequence ID" value="ORX13311"/>
        <property type="gene ID" value="AWC31_01935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.824"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="137"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX13311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="238" mass="26263" checksum="2C637FF949E6C6E4" modified="2016-06-08" version="1">MHHKGVDRIPGGYRALVVDDEVPLAGVIASYLTREQFEVSIAHNGHDAVRLAREVDPDVVVLDLGLPGVDGVEACRQLRTFSDAYVVMLTARDTEMDTIVGLSVGADDYMTKPFSPRELVARIRAMLRRPRTTTPAADARVFGPLRIDVAGRQVFIDDEPIMLTRTEFDVLAALSARPGVVLSRRQLLETVWEPTYVGNEHLVDVHIGHLRRKLGDDPAAPRFVTTVRGVGYRMGSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLJ7</accession>
    <name>A0A132PLJ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850239.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16305"/>
    <dbReference type="EnsemblBacteria" id="KWX23221">
        <property type="protein sequence ID" value="KWX23221"/>
        <property type="gene ID" value="AFM11_15470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7209"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="15"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="158" mass="16916" checksum="2B571FF88585B769" modified="2016-06-08" version="1">MTDAAESANFSKVDITAAPERAAQVRHEFSDWLRRNFTLDPVKTSDVLLAVNEALANAAEFAYVGAAEPGVMHVRADYDRDAATLTVTVTDEGAWRISEKTEDPARGRGIPLMHALTDRAVIDSTAAGTQVSLQWQDISAIPTAVADVAAQNCGSRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLM0</accession>
    <name>A0A132PLM0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850281.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23241">
        <property type="protein sequence ID" value="KWX23241"/>
        <property type="gene ID" value="AFM11_15575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7232"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="593" mass="65729" checksum="B2C8050F13A064C6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLN2</accession>
    <name>A0A132PLN2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16395"/>
    <dbReference type="EnsemblBacteria" id="KWX23203">
        <property type="protein sequence ID" value="KWX23203"/>
        <property type="gene ID" value="AFM11_15355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7186"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022454">
        <property type="entry name" value="CHP03883_F420-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03883">
        <property type="entry name" value="DUF2342_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="351" mass="38621" checksum="468F48E847ADD16D" modified="2016-06-08" version="1">MRHMSSPTMTAGRAVDWDFAATVGAKLARPAPAATDYTRRQAIDQLAESARAAELPVREVTGLNEGAELPEARIVDRTEWIRAATRSMRVMTGGDEDHKPGFITGRVTGAQTGAVLAFISSGILGQYDPFGPDGGELLLVYPNVIAVERQLRVTPTDFRLWVCLHEVTHRVQFRANPWLADHMSQALAVLTQDAGEDVAAVVGRLAQYVRNQRNGSAPDPNSAGILGLMRAVQAEPQRRALDQLLVLGTLLEGHADHVMDAVGPAVVPSVGTIRRRFDERRQRKQPPVQRVVRALLGFDAKISQYTRGKAFVDEVVSTVGMARFNTIWTEAETLPLPTEIDEPRRWIDRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLY7</accession>
    <name>A0A132PLY7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxybutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_16290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850539.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16920"/>
    <dbReference type="EnsemblBacteria" id="KWX23365">
        <property type="protein sequence ID" value="KWX23365"/>
        <property type="gene ID" value="AFM11_16290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7383"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="248" mass="26204" checksum="4EB5C640010CCA45" modified="2016-06-08" version="1">MTDLAGRTALVTGAASGIGAACARELTARGAVVTVADVDADGAGALAAEIGGKPWAVDLLDVAALERLELDCDILVNNAGVQSINPIEEFPPDKFRMLLALMVEVPFLLIRASLPHMYRQRFGRIINVSSVHGLRASEYKVGYVTAKHALEGLSKVTALEGGPHQVTSNCVNPGYVRTPLVTKQIADQARIHGIPEDDVVAQILLKESAIKQLVEPEEVGALVGWLASPAARMVTGASYTMDGGWSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM65</accession>
    <name>A0A132PM65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849655.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23393">
        <property type="protein sequence ID" value="KWX23393"/>
        <property type="gene ID" value="AFM11_13940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6891"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="27489" checksum="C00D6199FD4B4ADB" modified="2016-06-08" version="1">MTASSDGLVGYVRGQLEKPLAMVGGFFKMSVLTGKALLTRPFQWKEFVIQSWFLIRVAFLPTLAVSIPLTVLIIFTLNILLAEFGAADVSGAGAALGAVTQLGPLVTVLVVAGAGSTAICADLGARTVREEIDALEVLGIDPIERLVVPRVVASTFVAFMLNGAVITIGLVGGFFFGVYIQNVSAGAYVSTLTLLTGFPEVMISVIKATLFGLIAGLVGCYRGLTVAGGSKGVGTAVNETLVLCVVALFAVNVVLTTIGVRFGTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM96</accession>
    <name>A0A132PM96_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EspA_EspE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849792.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23460">
        <property type="protein sequence ID" value="KWX23460"/>
        <property type="gene ID" value="AFM11_14335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6975"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043796">
        <property type="entry name" value="ESX-1_EspA/EspE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18879">
        <property type="entry name" value="EspA_EspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EspA_EspE" evidence="2">
        <location>
            <begin position="93"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="502" mass="50807" checksum="27E392D5AAE0DC45" modified="2016-06-08" version="1">MGMLSDVADFGKDVIDDREKWADRFKKVGDFIERNAKGDKLERVAKAGRKLADFSKKFTDFFESRLGNRLVKAAKSPILAAGQHVIDGMKLTTGLGDPESGSRFGQGAERLGDAGQTLTAAFPSADWDSSGSNTYTGRNNEQVSRTQTMIGADQLVASVLSREAQQIAATRDNLDSQSDWLGDMSLITMATGCIPYVGKAAQIAAEVAMVSKAVGESTNQLMSMQDNASANAAEVRGAVSQYEAIADTAQATGGDEEFEPTDDDEVSSEARTEADAAAGSAAVPTAGSPTGGGGAPAPQQASMRATPSVPAGMPAGAGAVAPPGAMGGDVAGVFGAVLGSVMGPIGGLLGGVMQAAGQAAQAATQAATQAAQVASQAAGQSPDPAALAETDDKRDENSEDDGEGKEEKPRDDGQDREAAQTDGESDAEGPDEAGPGGNTAGEGEEGAAKTLPPDLAEASAEITGAGPAPVHISADFEQSQLRMPAAATLERGIPGSASAIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMS3</accession>
    <name>A0A132PMS3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848970.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02840"/>
    <dbReference type="EnsemblBacteria" id="KWX23636">
        <property type="protein sequence ID" value="KWX23636"/>
        <property type="gene ID" value="AFM11_12580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6606"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="44"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="485"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="628" mass="65850" checksum="03F721541263AEA8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMV9</accession>
    <name>A0A132PMV9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_14820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849959.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18080"/>
    <dbReference type="EnsemblBacteria" id="KWX23537">
        <property type="protein sequence ID" value="KWX23537"/>
        <property type="gene ID" value="AFM11_14820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7075"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="311" mass="33325" checksum="610EB16888109F1E" modified="2016-06-08" version="1">MSTTPTVHDVIIIGSGPAGYTAAVYAARAQLKPLVFEGTQFGGALMTTTEVENYPGFREGITGPELMDEMREQALRFGADLRMEDVDAVQLEGPVKTVTVGDETHQARAVILAMGAAARHLGVPGEEALLGMGVSTCATCDGFFFRDQDIVVVGGGDSAMEEATFLTRFARSVTLIHRRDEFRASKIMLERARANEKITFLTNTEITEIEGDPKVTGVRLRDTVTGEESKLAVTGVFVAIGHDPRSELVRGQVELDDEGYVKVAGRSTYTSVEGVFAAGDLVDHTYRQAITAAGSGCAASIDAERWLAENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMX2</accession>
    <name>A0A132PMX2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849136.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03205"/>
    <dbReference type="EnsemblBacteria" id="KWX23688">
        <property type="protein sequence ID" value="KWX23688"/>
        <property type="gene ID" value="AFM11_12920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6676"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="197" mass="21827" checksum="BA67626BC1DB1E1E" modified="2016-06-08" version="1">MPGADTASEAILDAALVEFERHGFRRVALDDVARRAGVSRTTIYRRFANRDELVGAVIERENVALFADIANELKAAGPQSNYYVEAFTLSILRFRRHRVLNQMIGDEPALVMELMHRHYGAAVERMAAALRVIFPPGFADKIGEQTVNDLADTILRYAATVLLLPSVQPLDTADDIRAFATRHFLPSLPVSLRAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN20</accession>
    <name>A0A132PN20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_13195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849276.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03480"/>
    <dbReference type="EnsemblBacteria" id="KWX23736">
        <property type="protein sequence ID" value="KWX23736"/>
        <property type="gene ID" value="AFM11_13195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6732"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="28232" checksum="1D2AA204010D7EF3" modified="2016-06-08" version="1">MTVLQGARDRVGRPWLVIGAIVAAAVIIPVLAGEQVADFGAALRPPGADHLAGTDHSGYDLLVRSAEGLRISLVIAAVCALAATVLGLVIGVGSALAGGWIDATVMRVVDGFNALPHLVVGIVVAAMWRGAPLAIIASIALTHWPAVARVVRAELLSLADAGWVQSARLAGASHWFIARHHLVPAVTGQALVAMVMLLPHAVWHESTLSFLGVGLSPDRASLGTMLGQARGDVLTGAWWTLAVPAFALMVTALAFASAGAAVRRRNAPPAGQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN37</accession>
    <name>A0A132PN37_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyphosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849244.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03420"/>
    <dbReference type="EnsemblBacteria" id="KWX23725">
        <property type="protein sequence ID" value="KWX23725"/>
        <property type="gene ID" value="AFM11_13135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6720"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="2">
        <location>
            <begin position="57"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="33126" checksum="4DF2FC3A6F17916F" modified="2016-06-08" version="1">MSKDSDSDLPEPWTHEPHTHLAFQPGDKVADIKTGDTPGFSGSKSDAPELQAERNDRFAELQEMLYARNKSGDDNRSVLLVLQGMDTAGKGGIVKHVVGAANPQGIRYTSFGKPTEEERAHHYLWRIRNALPPAGHIGVFDRSHYEDVLIVRVHDLVPPDVWGARYDEINTFERELVDAGTTLVKVAMFVSLDEQKARLAERLERPDKYWKYNPADIDERLLWPKYQEAYQAMLDRTSTDYAPWHIVPSDKKWYSRLAITELLIEALKGLDMTWPPADFDIEAEKKRLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNC1</accession>
    <name>A0A132PNC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_13835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23836">
        <property type="protein sequence ID" value="KWX23836"/>
        <property type="gene ID" value="AFM11_13835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6863"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="382"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="583" mass="62089" checksum="D78B783DEF76A8E9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNX3</accession>
    <name>A0A132PNX3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849293.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03530"/>
    <dbReference type="EnsemblBacteria" id="KWX23742">
        <property type="protein sequence ID" value="KWX23742"/>
        <property type="gene ID" value="AFM11_13245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6742"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="194" mass="20671" checksum="56740C97C32E6DBC" modified="2016-06-08" version="1">MTTTRELRGTTVGGDTWLKRYYFTRAAFSVAWVGAAFGFGDGPTAVVAALLLIYPVWDAVANLVDGQRNGGLRRNRTQAFNTAVSLLTTGAVAIALTQSMNAVLGVFGVWAALSGILQLATGVRRWKSVGAQWPMILSGAQSTCAGVMFLITSNAPEPPHITAIAPYAAFGAFYFLISAVWLAVSDARRRPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP84</accession>
    <name>A0A132PP84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848616.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09830"/>
    <dbReference type="EnsemblBacteria" id="KWX24103">
        <property type="protein sequence ID" value="KWX24103"/>
        <property type="gene ID" value="AFM11_12145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6508"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453517" evidence="1">
        <location>
            <begin position="24"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="243"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="402" mass="41960" checksum="895F9C4F53F49448" modified="2016-06-08" version="1">MRVRTLASGTALLALALTSCSSAETSQSEPTTTTTPPPVATPVIGSVLAAPVPVPATDGRTHLAYELMLTNTMPSNVTLTSVSALAGDRKLLTLSGDSLKYWTRLVGSPAAGANVLGPGQSAYVWLDVVADDPAQVPTELTHAVGVKVAKPMPPLIPPDLTETVAPVSVQTRKPVSISPPLAGEDWVDANSCCDMTPHRMALNPINGKVWAAERFAIDYVQLGADRTLFSGDKAKVESYPYFGAEIHAVADGPVVAVLDGLPEQTPGTAPSGLALDEYGGNHIVQDIGDGNYAFYAHLQPHSLKVKAGDQLSTGQVIAALGNSGNSDAPHLHFHVMDGPDPLASNGLPFVLKAFRLDSRLAGMGALDPLIDGRPVTLQPGFAARDQSEVSPLVLDVMTYATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPH7</accession>
    <name>A0A132PPH7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="13" type="ORF">AFM11_09585</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847196.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05640"/>
    <dbReference type="EnsemblBacteria" id="KWX24240">
        <property type="protein sequence ID" value="KWX24240"/>
        <property type="gene ID" value="AFM11_09585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5954"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="25"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="445"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="621"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="818"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="540"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX24240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="883" mass="98428" checksum="0C7B0561C26E2B60" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPI1</accession>
    <name>A0A132PPI1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-E domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847071.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05835"/>
    <dbReference type="EnsemblBacteria" id="KWX24203">
        <property type="protein sequence ID" value="KWX24203"/>
        <property type="gene ID" value="AFM11_09390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5915"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007296">
        <property type="entry name" value="DUF403"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04168">
        <property type="entry name" value="Alpha-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-E" evidence="1">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="325" mass="36255" checksum="6C283D4C96F16F14" modified="2016-06-08" version="1">MLARNAESLYWIGRYVERADDTARILDVTIHQLLEDSSVDPDHASRTLLRVLGIDPPKDRLDVWSLTDIVAFSRDTYGGASIVDAISAARENARGAREVTSTEIWECLNTTYNALAERERAAKRLGPHEFLSYVEGRAAMFAGLADSTLSRDDGYRFMLLGRAIERVDMTVRLLLSRVGDSGSSPAWVTLLRSAGAHDTYLRTYRGVLDAGRVVEFMMLDRLFPRSIFFSLRLAEISLDELLNRPHNRLGATAEAQRLLGRARSELEFMQPGVLLESLESRLAGLQKTCREVGDALALQYFHSAPWVAWTDAGHADALVIEEGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPP7</accession>
    <name>A0A132PPP7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-3-deoxygluconate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05225"/>
    <dbReference type="EnsemblBacteria" id="KWX24310">
        <property type="protein sequence ID" value="KWX24310"/>
        <property type="gene ID" value="AFM11_10000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6036"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="317" mass="33073" checksum="B38BA0F7986698E8" modified="2016-06-08" version="1">MGFDVVAIGESLGLLTAPRPGRLHHNPALRLGFGGAESNVAIGVARLGGSAAWIGRIGADSLGELILRELRAEAVHTFPALDHDAATALMIKERPHPGASQISYYRRGHAGSRLQPCDLPATVVGDTQILHITGISAGLGEGPVSAVHAAMDLAAAAGAAVSFDVNHRDALWADRDAAAAAYRELARRADIVFAGEDEAHLLTDVETPDRQLDALLGMGVECSVVKRGAEGAMAATVDWRHSAPAVPVPVVDTVGAGDAFVAGWLAERARGADPRQCLDTALACGAFACTGEGDWESAPTRDDLRWLREGAADPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPW7</accession>
    <name>A0A132PPW7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847631.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18895"/>
    <dbReference type="EnsemblBacteria" id="KWX24381">
        <property type="protein sequence ID" value="KWX24381"/>
        <property type="gene ID" value="AFM11_10460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6132"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="57"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="146" mass="15791" checksum="BD6FBB69A826660A" modified="2016-06-08" version="1">MVSDVSTQKALAPEISTWPEENPQLIGSRCADCSATTFPAQARCPRCSSANTTETLLPRRGTLIAWTTQGFPPGPPYKGPTGKDFVPFGVGLVQLGDTIRVEGRLTENDPAKLQFGQEVELTMIPFTTDEDGNEIVTFAFTPEVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ72</accession>
    <name>A0A132PQ72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847768.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19240"/>
    <dbReference type="EnsemblBacteria" id="KWX24424">
        <property type="protein sequence ID" value="KWX24424"/>
        <property type="gene ID" value="AFM11_10725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6184"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="396" mass="44990" checksum="E2875BD06B05FEE5" modified="2016-06-08" version="1">MAVPTAPTESDVYYDPYNVDLNMNPYPVFARIREEAPLYYNEQHDFYALSRYDDVNAAVIDHETFISGRGAVLEIIKSGMEIPPGTLIFEDPPIHNIHRNLLSRMFTPRKVLALEPQIREFTARCLDPLVGSEKFDFVNDLGEQMPMRVIGMLLGIPEERQRQITDHGEEILQGQTVDALATGEVFAEFIDWRAEHPSDDIMTDLLNAEFEDETGTVRKLRRDELLLYLTVIATAGSETTTRLIGWAGKTLADYPDQRRQLVEDPSLIPQAIEEILRWEPPALQIARYVTRDVEYYGQTVPEGSAMLMLVGAANRDHRRFAPDGDVFDIHREQRSHMTFGAGTHFCMGNALARLEGRIALEEILKRFPQWEVDWPNAVPSETAAVRGWAAMPTFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ86</accession>
    <name>A0A132PQ86_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_09975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847932.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05250"/>
    <dbReference type="EnsemblBacteria" id="KWX24483">
        <property type="protein sequence ID" value="KWX24483"/>
        <property type="gene ID" value="AFM11_09975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6031"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="17"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="235" mass="24969" checksum="0F6C54D55D167FD9" modified="2016-06-08" version="1">MFEGLGTQHLSLIWHGALVTLQICTLSVLFGGVLGIVIGLMSTGPIRTLRWVAAIYVAVIRGIPVLLIIFFVYFGIPLLAPGSSLSEYWAAVIALSVFASAYIGELVRGSVQAVPRGQFEAADALGLSYAQRMRWVILPQAARVIVPPGVGFLVILIKDSSLVAVIGLIELTRAGNVVSSLTADPITTYLIVGAGYFVICYALSSLGRRYERKLGIHVKAPAVGDTLTLTTGANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ91</accession>
    <name>A0A132PQ91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847829.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19350"/>
    <dbReference type="EnsemblBacteria" id="KWX24444">
        <property type="protein sequence ID" value="KWX24444"/>
        <property type="gene ID" value="AFM11_10835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6206"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="802" mass="87428" checksum="450314AB670163B4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQA2</accession>
    <name>A0A132PQA2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847912.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05625"/>
    <dbReference type="EnsemblBacteria" id="KWX24475">
        <property type="protein sequence ID" value="KWX24475"/>
        <property type="gene ID" value="AFM11_09600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5957"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="435"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="656" mass="71152" checksum="6C3A1256844DD6A9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQN0</accession>
    <name>A0A132PQN0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846316.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00090"/>
    <dbReference type="EnsemblBacteria" id="KWX24641">
        <property type="protein sequence ID" value="KWX24641"/>
        <property type="gene ID" value="AFM11_08165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5484"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="329" mass="36373" checksum="B392B399E2514105" modified="2016-06-08" version="1">MRFGLFIPQGWRLDLVDIPTQQHWPVMKDLATYADGGAWDSLWVYDHFHTVPVPTDEATHEAWSLMSAYAATTSRIKLGQMCTAMSYRNPVYLAKVATTADIISGGRIQMGIGGGWYEHEWRAYGYGFPSAGVRLGRLDEGVQIMRDAWRDGRVSFEGKHYQVDDAIVAPKPLQENSIPLWIAGGGEKVTLRIAAKYAQYTNFTSAPDGFAHKSEVLAGHCREVGTDYDAIVRSANFNAVIGDSEADVKDRIARLRDRQVPVAGEAAVDAMLSTMSAPESASGTPEQVVEKLQRMRDLGCEYAILYFPEAAYDRSGIELFEQKVIPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQP4</accession>
    <name>A0A132PQP4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_07515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845985.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22015"/>
    <dbReference type="EnsemblBacteria" id="KWX24527">
        <property type="protein sequence ID" value="KWX24527"/>
        <property type="gene ID" value="AFM11_07515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5351"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="213"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="36266" checksum="668BAD6108063116" modified="2016-06-08" version="1">MNFSELHDEMRSVAADLLAKDTVDWPLLIQAGWVGLDVPDHLGGAGATFAEVAVICEEIGRAAARTAYLGGAVLGIGALLALEPNEFRDELLADAVEGRQRVTLALPGETADEPFELATTRLGWRVHGQATFVSDAVGAQRLLLPARDSDGVAVIVDVTADAVGLTVADQPVLDASRSLATVSAHGVEVDHAAVWRFDGDPDTRLRELGERAALAVACDSLGVAQAMLDTTVSYVGVRRQFGRPIGSFQAVKHACADMLVRISVARQLVTAAVADSDSTAISMAKSYACDTAVDVAGKAMQLHGGIGYTWESGVHVYLKRAALNRSLFGSPAAHRARLAQRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQU1</accession>
    <name>A0A132PQU1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_08485</name>
        <name evidence="7" type="ORF">AWC31_00340</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000001">
        <property type="protein sequence ID" value="ORX19342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846480.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00340"/>
    <dbReference type="EnsemblBacteria" id="KWX24696">
        <property type="protein sequence ID" value="KWX24696"/>
        <property type="gene ID" value="AFM11_08485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19342">
        <property type="protein sequence ID" value="ORX19342"/>
        <property type="gene ID" value="AWC31_00340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5545"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="5">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="5">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX19342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="222" mass="24686" checksum="8186BB110BE379D4" modified="2016-06-08" version="1">MRTQYHEQLDSLTDQLGVMCELAGTAMERATQALLQADLVLAEQVITDHDQMTALSAQAEESAFVLLALQAPVAGDLRSVVGSIQIVADVDRMGALALHVAKIARRRHPQHALPEEVNGYFSEMGRVAVELGHAAREVLITRDPEKAARIQEEDDAMDDLHRHLFTVLMDREWKHGVTAAVDVTLLSRFYERFADHAVEVARRVIFQVTGTYPDGEKVANQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQV9</accession>
    <name>A0A132PQV9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846444.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24685">
        <property type="protein sequence ID" value="KWX24685"/>
        <property type="gene ID" value="AFM11_08430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5534"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="166" mass="18696" checksum="2603D0A36BAB1521" modified="2016-06-08" version="1">MTEETVVAKTIVNAPSEAVFDLLADPSTHAAIDGTGWVREPVDATRVTGTGQVFRMAMYHDLHPNKHYEMANRVEVFDRPRAIAWLPGTEPRHIPGRDASDDSTVEYGGWIWRYDLASAGVDRTEVTLTYDWSNVPPRDRDIEFPPFGPEHLDNSLRHLAELAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQW5</accession>
    <name>A0A132PQW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846570.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13675"/>
    <dbReference type="EnsemblBacteria" id="KWX24731">
        <property type="protein sequence ID" value="KWX24731"/>
        <property type="gene ID" value="AFM11_08695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5589"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="212" mass="22745" checksum="80B7C64CC4D1CB94" modified="2016-06-08" version="1">MQLTHFGHSCLLASISDTTVLFDPGNFSHGFEGITGLSAILITHQHPDHADTTRLPALLDANPQAALYADPQTAAQLGEPWKAVHVGDEFRIGSLNVRGVGGRHAVIHPEIPVIDNISYLLGDDEHPARLMHPGDALFVPGEPVDVLATPAAAPWMKISEAVDFLRAVAPARAVPIHQGIIDPGARGIYYGRLAEMTSTDFQVLDPENGTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR04</accession>
    <name>A0A132PR04_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease 2</fullName>
            <ecNumber evidence="3">3.4.21.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.83" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846583.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13645"/>
    <dbReference type="EnsemblBacteria" id="KWX24735">
        <property type="protein sequence ID" value="KWX24735"/>
        <property type="gene ID" value="AFM11_08725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5594"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="479"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="714" mass="79932" checksum="6B3B56B45FA2E5C7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR33</accession>
    <name>A0A132PR33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MCE-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846730.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13365"/>
    <dbReference type="EnsemblBacteria" id="KWX24783">
        <property type="protein sequence ID" value="KWX24783"/>
        <property type="gene ID" value="AFM11_09005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5651"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="124"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="400" mass="42585" checksum="ED8362B41DBFF7BC" modified="2016-06-08" version="1">MSNGSAKRSHVRIAAAILAAIVLAAVVFTYLSYTAAFTPTDTVTVTSQRAGLVMDRDAKVKYRGIQVGKVSDIEYAGNEAKLTLSMNRNELRYIPSNATVRIAGNTVFGAKSVEFLPPEEPKETSLRPGTNVAAKDVQLEVNTLFQTLSDVLNKIDPVSLNATFTALGEGLRGNGDDLGAAMSGLNYYLQQLNPKLPTLQDDLAKTAVVANIYGDAGPDIARVIDNVPALNRTIIDEQANLNATLLAATGLANNGTATLEPAADDYIAAIQRLRAPLKVAGDYSPEFGCILQGVSIGVDRFAPIIGGIRPGLFVASNFLPGAPAYTYPESLPIVNASGGPNCRGLPNIPSKQFGGSWYHAPFLVTDNAYVPFQPNTELQFDAPATLQFLFNGAFAERDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR73</accession>
    <name>A0A132PR73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846966.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13770"/>
    <dbReference type="EnsemblBacteria" id="KWX24848">
        <property type="protein sequence ID" value="KWX24848"/>
        <property type="gene ID" value="AFM11_08600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5571"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="420" mass="46817" checksum="00813C89C84E1998" modified="2016-06-08" version="1">MTKIAFRFCFVYFGLFCLLFAQILFVFTGIIGQWLPEQAVMGQMLLADPVLGWVGRTVFGVDAELRRDSGSGDQAAIWIFVFCLLVVAVVATAVWSVADRRRAEYSRLWAWFLTGLRLCVAGQMLFYGFAKLIPTQMPAPPLAALLRPYGDFSPASVLWLQVGTSYPYEMMLGAVEVLAGVLLFLPRTATLGALLGLASMVQVFLLNMTFDVPVKILSGHLLLMSLVLLTPQVRRLANILVLQRPSDPASQPELFTDARANMRSARVQALLGVWALIGCAWISWQAWGEYGGGRVKPELYGIWAVREFQVDGTARPPLTTDETRWQRLVFDEPGVVSYQRMNGELVPAQAEMTDGRIALSAPDGSALADFTVSRPDPQRLELAGQLDGRAVRIALEQVDLNQFTLRNRGFHWVQDYPYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRF8</accession>
    <name>A0A132PRF8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845036.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12980"/>
    <dbReference type="EnsemblBacteria" id="KWX24916">
        <property type="protein sequence ID" value="KWX24916"/>
        <property type="gene ID" value="AFM11_05595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4309"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="275" mass="28835" checksum="09EE93DD050434A4" modified="2016-06-08" version="1">MSTPDTPLAGRVAYVTGAARGQGRSHCVRLARAGADIVAIDACASVAEHNGYPSATPDDLAETVRLVENEGRKILAAEVDVRDAAGQRRVVADGIEQFGRLDIVVANAGVLNWGRLWEISARQWQDILDVNLTGVYNTVQAVVPPMIAAGNGGSIITISSAAGIKAVPGCRHYCASKFGVVGLTNSLAVELGEFGIRVNSVHPYGTDTPMGNDVSMYQVFADHPNYIHSFSPGALPTDSLAPPDTISDIVVWLAGDASSLVTAAQIPADKGYLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRJ1</accession>
    <name>A0A132PRJ1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="9" type="ORF">AFM11_05760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845092.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11620"/>
    <dbReference type="EnsemblBacteria" id="KWX24943">
        <property type="protein sequence ID" value="KWX24943"/>
        <property type="gene ID" value="AFM11_05760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4343"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="414" mass="44266" checksum="E70AF13E7EE6DB7D" modified="2016-06-08" version="1">MAEKWGAERAQPVSVGPPRRGMSRAERARQARNNRKRRLARGLSLALLIMVAVGAVFLGSKLWHGMSGSGSDYAGEGVADVVIQVHDGDSTTAIGETLQDHKVVATVKAFVDAAQGNEAISAIQPGFYKVRTEIPAANAVERLADPESRVGKLTIPEGRQLDDITDVKTNAVTAGIFSLISQASCVELDGEQRCVSVDDLRAAAGSAPPAALAVPEWATGPVTAMGGDHRRLEGLIAAGTWNVDPAASAQDILTTLISTSSTMYTQGGLLDTAAAMNMSPYQILTVASLVQRESKPQDFAKVARVIYNRLADHRKLEFDSTVNYSLDRQEVATTDADRAQVTPWNTYASEGLPQTPICSPGTDALVAAEHPAPGDWLYFVTIDLQGTTLFTRDYDEHLANIELAQRNGVLDSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRN5</accession>
    <name>A0A132PRN5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein AFM11_06070</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29590"/>
    <dbReference type="EnsemblBacteria" id="KWX24996">
        <property type="protein sequence ID" value="KWX24996"/>
        <property type="gene ID" value="AFM11_06070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4406"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="307" mass="33534" checksum="4A95B9CAA3B3257C" modified="2016-06-08" version="1">MSGDLHENGPDTGIAEVDEESGIDVVLVTGLSGAGRGTAAKVLEDLGWYVADNLPPELIARMVELGLAAGSRITQLAVVMDVRSRGFTGDLDWVRHDLATRNITPRVLFLEASDDILVRRYEQNRRSHPLQGNQTLAEGIAAERAMLAPVRAGADLVIDTSKLSVPALRESIERAFGGETVAYTNVTVESFGYKYGLPMDADTVMDVRFLPNPHWVDELRPHTGQHPDVRDYVLGQPGAKDFLDTYHRLLDVVIAGYRREGKRYMTVAIGCTGGKHRSVAIAEALAERLQGGDGLTVRALHRDLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRP2</accession>
    <name>A0A132PRP2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_06125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845201.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29550"/>
    <dbReference type="EnsemblBacteria" id="KWX25006">
        <property type="protein sequence ID" value="KWX25006"/>
        <property type="gene ID" value="AFM11_06125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4417"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041483">
        <property type="entry name" value="TetR_C_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17929">
        <property type="entry name" value="TetR_C_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="226" mass="24009" checksum="D522BFF6D49ECA86" modified="2016-06-08" version="1">MVRPVEPVTFKRARTAENKRARAAALMEAARSLALESGVAAVTLTAVADRAGVHHSAVRRYYASHKDILLHLAAEGWGRWSAAVCESLAAPGPVSPARVAEALVGGLLQDVLFCDLLAYLPLHLEHEVKPEQVVKVKRQSYPAVMSIAEAIERALPALGRQGAADMLSSATALAGTLWQVVHPPADLVDAYATEPAVPPEFDFEFGPTLTRLLTAMCTGLAAQSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRR1</accession>
    <name>A0A132PRR1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgl</name>
        <name evidence="9" type="ORF">AFM11_06235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845240.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29440"/>
    <dbReference type="EnsemblBacteria" id="KWX25026">
        <property type="protein sequence ID" value="KWX25026"/>
        <property type="gene ID" value="AFM11_06235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4440"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="11"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="244" mass="25524" checksum="C4254714B0CA7A43" modified="2016-06-08" version="1">MSDTVIERYPDTAALVAAAGDRLVDAIKSAITARGQATIVLTGGGTGIGMLKRVGERSSEIDWAKVHLYWGDERFVPQDDDERNDKQAREALLDHLDIPAVNVHAMAASDGEFGDDLDAAAEGYAQLLAANFDAPGPEFDVHLLGMGGEGHINSLFPDTAAVRETARLVVGVTDSPKPPPRRISLTLPAVQSAREVWLVVSGEAKADAVAAAVGGADPVDVPAAGGIGREKTVWLLDEAAAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS33</accession>
    <name>A0A132PS33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase</fullName>
            <ecNumber evidence="7">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltD</name>
        <name evidence="7" type="ORF">AFM11_06980</name>
        <name evidence="8" type="ORF">AWC31_28670</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845520.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28670"/>
    <dbReference type="EnsemblBacteria" id="KWX25156">
        <property type="protein sequence ID" value="KWX25156"/>
        <property type="gene ID" value="AFM11_06980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13768">
        <property type="protein sequence ID" value="ORX13768"/>
        <property type="gene ID" value="AWC31_28670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4595"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="40"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="155"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX13768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="500" mass="53585" checksum="04826333345B0715" modified="2016-06-08" version="1">MADPTGFLRVPKIEAAKRPVDERVGDWREVYERQDPHERAGEVSQQARRCMDCGIPFCHSGSAGCPLGNLIPEWNDLVRRGRWDAASDRLHATNNFPEFTGRLCPAPCEAACVLSIAEEQTGGSVTIKRIEQTIADQAWMDGTVEPQPAAISTGKSVAVVGSGPAGLAAAQQLTRAGHDVTVYERDDRLGGLLRYGIPEYKLEKSVLNQRLAQMRAEGTRFVTECEVGVDVTVEQLRNRHQAVVLAVGALRGRDNDVPGRELDGVHLAMEHLVPANRECEGDGASPISAAGKHVVIIGGGDTGADCLGTAHRQGAASVTQLDYNPEPPEARDETLSPWPTWPLVLRTSPAHAEGGARHFEVAVQRFLGDEKGHVRAVEIAEVRVTRDADGRRQITPVGDSLQIPCDLALLAIGFEGVEHMALIDDLGLTLNRRGALSCGSDWQTDAPGVFVCGDAHRGASLVVWAIAEGRSAAHAVDAYLMGESDLPSPVRPGALPLSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSB7</accession>
    <name>A0A132PSB7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_07030</name>
        <name evidence="7" type="ORF">AWC31_17685</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845547.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17685"/>
    <dbReference type="EnsemblBacteria" id="KWX25164">
        <property type="protein sequence ID" value="KWX25164"/>
        <property type="gene ID" value="AFM11_07030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17523">
        <property type="protein sequence ID" value="ORX17523"/>
        <property type="gene ID" value="AWC31_17685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4605"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="62"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX17523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="301" mass="33489" checksum="C929128612B30E75" modified="2016-06-08" version="1">MTDASPPPAIDAVPLRHPWRWVAAVALLVLLGLFVYGAATNEAYGWDTYWKYLFDQRLSEAAWNTLQLTIFSMVLAVVLGVILAVMRLSPNPVLKAVSWTYLWIFRGTPVYVQLVLWGLVPVLYQNIKLGVPFGPTFFEFSLSDPNFFMLAILGLGLNEAAYMAEIIRAGINSVPEGQSEASTALGMSWPMTMRRTVLPQAMRVIIPPTGNEFISMLKTTSLVTAVPYSFELYGRARDIGVALFQPIPLLLAASTWYLAITSILMVGQYYLERYYARGASRKLTSKQLEALAKAQMGEPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSJ6</accession>
    <name>A0A132PSJ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843960.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21765"/>
    <dbReference type="EnsemblBacteria" id="KWX25328">
        <property type="protein sequence ID" value="KWX25328"/>
        <property type="gene ID" value="AFM11_03320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2538"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="289" mass="30941" checksum="761E90572BDCC4B9" modified="2016-06-08" version="1">MSIELRTMRYVIAIAEAGGFQRGAEQLHMAQPPLSRQIRELERELGVALFHRRPTRLTAEGHVFVKHARAVLAEVERAVAETRAAGGAAAGVVRVGCGPMSGSTDVPALVHAVAARHPGVVIEVSELWDTALCSALVSGEVDIAFGWHLSVGGELARCVLRREPYVVVVADDHPLAGRTAVKLGELAGDTFRFLPRRFAAAYYDAVLHAVRSTGVEFTVWENPLPGLRHFGDLHTGGFNVLPTSISRSLPAGLTCLTILDDLPQAELIMVWRPGAGKAVEAVAATARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSL3</accession>
    <name>A0A132PSL3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29190"/>
    <dbReference type="EnsemblBacteria" id="KWX25254">
        <property type="protein sequence ID" value="KWX25254"/>
        <property type="gene ID" value="AFM11_06485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4490"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="575" mass="62479" checksum="7376C4BE2ACA9DF9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSR9</accession>
    <name>A0A132PSR9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25314">
        <property type="protein sequence ID" value="KWX25314"/>
        <property type="gene ID" value="AFM11_03230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2521"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453556" evidence="1">
        <location>
            <begin position="28"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="105" mass="10758" checksum="93AC640ECDE75B5B" modified="2016-06-08" version="1">MKMTAKCSAAGVGLIASALACGPSATAAPSEASATETINQLQSEGYRVILSKVGNGAIENCTVNAVRPGRTVTGPQPPVNGNFTLMGPGQVLQYTTVYVDLDCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT56</accession>
    <name>A0A132PT56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845782.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12870"/>
    <dbReference type="EnsemblBacteria" id="KWX25232">
        <property type="protein sequence ID" value="KWX25232"/>
        <property type="gene ID" value="AFM11_05495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4289"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="73" mass="7958" checksum="0C50E1409F27D744" modified="2016-06-08" version="1">MFDRGQRVYRDGTGQIIAPLDQVRFERHMQLTSSSPKLVAVTPVGVRVLKRGNPFGGGVGNLDEVLTAVVHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTY6</accession>
    <name>A0A132PTY6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_00065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842052.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33170"/>
    <dbReference type="EnsemblBacteria" id="KWX25734">
        <property type="protein sequence ID" value="KWX25734"/>
        <property type="gene ID" value="AFM11_00065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.13"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="204" mass="22400" checksum="88A051AE72B3C6D3" modified="2016-06-08" version="1">MSVRPEPQTAGGRSRSARTTRLSRDSIVNAALTFLDREGWDALTINALASQLGTKGPSLYNHVHSLEDLRRTVRMRVVDDIIEMLNTVGQGRTRDDAVMAMASAYRSYAHHHPGRYSAFTRMPFGGDDPEYSAATKAAAGPVIAVLASYGLEGEDAFYAALEFWSALHGFVLLEMTGVMDDIDTDAVFTDMLLRLASGMERRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU10</accession>
    <name>A0A132PU10_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_00585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842320.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33700"/>
    <dbReference type="EnsemblBacteria" id="KWX25828">
        <property type="protein sequence ID" value="KWX25828"/>
        <property type="gene ID" value="AFM11_00585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.120"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="388" mass="41703" checksum="FCDBEFC4D965238C" modified="2016-06-08" version="1">MNLHDLDDDDRVIAETAAAFAEKRIAPYALEWDEKHHFPTDVLREAAELGMAAIYCREDAGGSGLRRIDAVRIFEQLAAADPTIAAFLSIHNMCAWMVDSFGTHEQRKTWVPRLASMESIASYCLTEPGAGSDASALRTRAVRDGEDYVLDGVKQFISGAGTSDVYVVMARTGGEGPRGISAFVVEKDTPGLSFGADEQKMGWNAQPTAQVIFEGVRVPADAMLGGTEGEGTGFGIAMNGLNGGRINIAACSLGGAQAAYDKAVGYLADRQAFGGALLDEPTVRFALADMATGLETSRNLLWRAASALDADHPDKVTLCAMAKRYVTDTCYDVADQALQLHGGYGYLREYGLEKIVRDLRVHRILEGTNEIMRVVIGRAEAARARASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU28</accession>
    <name>A0A132PU28_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25849">
        <property type="protein sequence ID" value="KWX25849"/>
        <property type="gene ID" value="AFM11_00710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.145"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041669">
        <property type="entry name" value="TetR_C_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17918">
        <property type="entry name" value="TetR_C_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="216" mass="24243" checksum="81B352ACE47947A0" modified="2016-06-08" version="1">MFEKPPSRQAAARTTVVQRRGIARMETILATAESLLAEQGYAAATLKGVGERAGIPTASLYHYFTDRRQLDAELGRRHVRALDERFAEALSHPRVQTLRDAVDAMIDPLFTYCREHPGMVQLWFVGRSSILRELADGFDEAWAEQLWRFLVARSLIRPGTPLLVVQLVFEVGDQIFDIAFRRSPTGDDATIDEGCRVLTAYLETYAPSAAERDTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU47</accession>
    <name>A0A132PU47_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844944.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25717">
        <property type="protein sequence ID" value="KWX25717"/>
        <property type="gene ID" value="AFM11_05055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2892"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="71" mass="7496" checksum="F66C78989EE8418D" modified="2016-06-08" version="1">MAVDTRVVVYPGSDEELHGTVVEDFADLAGTAVEIAGERIVGPARRWAVNVDDGGLVFVDDDSIVLEAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUX9</accession>
    <name>A0A132PUX9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843321.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35320"/>
    <dbReference type="EnsemblBacteria" id="KWX26136">
        <property type="protein sequence ID" value="KWX26136"/>
        <property type="gene ID" value="AFM11_02545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.522"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="154" mass="16523" checksum="7767AB72DFE7A098" modified="2016-06-08" version="1">MAQKADRIRRIRAVVLTALMITALGLLLTRCPANRDGMPGQLASAMEETVSAARSAAMALDLRMRDRSTPQLASVQISDARSDVVKAYEGIAELKAEDPVDIARQTLLTESMTTIVRQLNAASATLREVTATPDLGKLRADLVAAADALETGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV67</accession>
    <name>A0A132PV67_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_01140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842613.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25922">
        <property type="protein sequence ID" value="KWX25922"/>
        <property type="gene ID" value="AFM11_01140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.234"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="147"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="301" mass="30513" checksum="04BE061E767FF294" modified="2016-06-08" version="1">MSSPIRAGLFGALGMTFVGGSVAVSGALADAPLHTAQALRYAVACVLLLAWVRLTGRPLRRPRGAEWLWLIGVTASGLVLFNVALVHGSQHAEPAVLAVAVACVPIALATFGPLLEGHRPHTRILFAALVVSVGAVVVEGLGRADAIGLAWAIVVFVCEAGFTLLAVPVLAAHGPAGVSVHTTWLAAAMFGVLALTTEGWRAAVDFDAGEVLAIGYLAVGVTAIAFILWYTCVRGLGTGRAGLLTGVAPVAAAVIGIPLTGDIPGVAVWCGVGLIGCGLAMGLGDNAERELVGQISAKTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV90</accession>
    <name>A0A132PV90_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">AFM11_01200</name>
        <name evidence="6" type="ORF">AWC31_34240</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003892970.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A132PV90"/>
    <dbReference type="STRING" id="59750.AWC31_34240"/>
    <dbReference type="EnsemblBacteria" id="KWX26233">
        <property type="protein sequence ID" value="KWX26233"/>
        <property type="gene ID" value="AFM11_01200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12110">
        <property type="protein sequence ID" value="ORX12110"/>
        <property type="gene ID" value="AWC31_34240"/>
    </dbReference>
    <dbReference type="GeneID" id="66733036"/>
    <dbReference type="PATRIC" id="fig|59750.3.peg.246"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="100" mass="10763" checksum="06537F104C1F9400" modified="2016-06-08" version="1">MASVNIKPLEDKILVQANEAETTTASGLVIPDTAKEKPQEGTVVAVGPGRWDEDGEKRIPLDVAEGDTVIYSKYGGTEIKYNGEEYLILSARDVLAVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVN7</accession>
    <name>A0A132PVN7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_02295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843187.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35075"/>
    <dbReference type="EnsemblBacteria" id="KWX26092">
        <property type="protein sequence ID" value="KWX26092"/>
        <property type="gene ID" value="AFM11_02295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.470"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="3">
        <location>
            <begin position="62"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="381" mass="43491" checksum="6D09C318ACDDB716" modified="2016-06-08" version="1">MNAPKYALTPEQADAFGRELDAIRERVIADLGERDATYIRKIIKAQRTLEVGGRALMWFPPTWLPGTAMLAISKILDNMEIGHNVMHGQYDWMGDPALSSKAFEWDTACPADQWRHSHNYMHHTYTNIVDMDRDIGYGILRMSEDQKWSPYYLGNPLYAFLLMVLFQYGVALHEMETERIRAGEISIADKRDVLRGIWAKTKKQTLKDYVAFPLLAGPFAPFVFAGNLTANLTRNVWAFMIIFCGHFPDGTQEFSIEETENETRGMWYFRQLLGSANLTGGKWFHILSGNLSFQIEHHLFPDIPAHRHAEISVEVREICERYGLPYNTGPLYKQFGTVVRKIVKLAFPWGGKPKDPEPADVKEPAPEPAPQPICEPELVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAX9</accession>
    <name>A0A132PAX9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000047">
        <property type="protein sequence ID" value="KWX19468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859935.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12665"/>
    <dbReference type="EnsemblBacteria" id="KWX19468">
        <property type="protein sequence ID" value="KWX19468"/>
        <property type="gene ID" value="AFM11_35705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5877"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="120"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="210" mass="22787" checksum="02B0EDFD1A1AFAEB" modified="2016-06-08" version="1">MASDSDLAGNHPGGGFNPPEPTDRGGPDYGRFVEAVRTLQDHARAADAPDDVITEAANLIEKVSALLAPYDADEWNSPSGRRMDLPNRGNVSSVPVHLDVTADNQVTGTALFRRFHLGRNGAVHGGWLALLFDSLLGYTAAKLTRSPYQRTGYLHVNYRKIAPIEKELQVEAGIDRIEGRKVFVTGRLCDGADVLTEAEALFVRLKPGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB32</accession>
    <name>A0A132PB32_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_35425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000044">
        <property type="protein sequence ID" value="KWX19504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_017682184.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19504">
        <property type="protein sequence ID" value="KWX19504"/>
        <property type="gene ID" value="AFM11_35425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5818"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025296">
        <property type="entry name" value="DUF4158"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002513">
        <property type="entry name" value="Tn3_Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01526">
        <property type="entry name" value="DDE_Tnp_Tn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13700">
        <property type="entry name" value="DUF4158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF4158" evidence="7">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_Tn3" evidence="6">
        <location>
            <begin position="588"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX19504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111504" checksum="BA45601817A0C64E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBV8</accession>
    <name>A0A132PBV8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858827.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08080"/>
    <dbReference type="EnsemblBacteria" id="KWX19810">
        <property type="protein sequence ID" value="KWX19810"/>
        <property type="gene ID" value="AFM11_33675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5071"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="105" mass="12264" checksum="1E49157139895DE5" modified="2016-06-08" version="1">MDVFEAVAEPNRRALLDALIDGERTAGELVATLPELTQPTVSRHLKVLREVGLVEMRPDAQRRIYALRADGLVQIDEWIERYRRYWTNHLDALERHLTKTQKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC14</accession>
    <name>A0A132PC14_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="7" type="ORF">AFM11_33370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858663.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02345"/>
    <dbReference type="EnsemblBacteria" id="KWX19873">
        <property type="protein sequence ID" value="KWX19873"/>
        <property type="gene ID" value="AFM11_33370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5006"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="359" mass="39194" checksum="150100DE279ACC74" modified="2016-06-08" version="1">MTDTDTAPAIEALLAEHADLERQLADPNLHSDAAAARKVGRRFAQVSPVVATYRKLEAARGDLEAARELAADDASFAAEVDELAATVAELDRQLTDQLAPRDPHDADDIVLEVKSGEGGEESALFAADLARMYMRYAERHGWSVTMLDETTSDLGGYKDATLSIRSKGDSADGVWARLKFEGGVHRVQRVPVTESQGRVHTSAAGVLVYPEPEEVEEVAIDESDLRIDVYRSSGKGGQGVNTTDSAVRITHLPTGIVVTCQNERSQLQNKARAMQVLAARLQALAEEQAQADASADRASQIRTVDRSERIRTYNFPENRIADHRINFKAHNLDQVLDGDLDPLFDALAEADKQARLQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCB8</accession>
    <name>A0A132PCB8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_33195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858611.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17030"/>
    <dbReference type="EnsemblBacteria" id="KWX19969">
        <property type="protein sequence ID" value="KWX19969"/>
        <property type="gene ID" value="AFM11_33195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4971"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="321" mass="34243" checksum="B57082B2ECDBDB38" modified="2016-06-08" version="1">MSSAENTTKDESFLTVAIALGANALIAIAKTVVAGITGSASMLAEAAHSWADTGNEVFLLIGTRKSMKPADAEHRLGYGRAGYIWSMFAAFGLFTVGAVVSIWHGISSLGGEAETTSYGWAYAVLAVSFVLEGTSFAQALQQTRSGAVRRRIHPLRYIRVTSNPMLRAVFAEDLSALIGIVIAAAGIVLHELTGNAIWDAIGSILVGLLLGGVALFLIGRNMDFLTGEAVTPRGRDNVLRQLLDHHDIERVSYLHMEWVGADRIYLVAAVDLTGDAAESDVATRLNAIADALQSRPEIVRAVLTLTRPGDTTDLRPISARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCJ9</accession>
    <name>A0A132PCJ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858007.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20049">
        <property type="protein sequence ID" value="KWX20049"/>
        <property type="gene ID" value="AFM11_32275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4784"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="187" mass="19950" checksum="99627FB91EB8D71C" modified="2016-06-08" version="1">MEGVEAEGAPARYRLLVFAPDIAELVTVAGGWLFDRAMAGWDVTGLVAEGSDVRPLRILGVGTAILESVLSMDTPANLPSAISIAGHHYSSDPRIRELIRRIADGGAAELTVWGEACPADLKAILLPVCYEPTSAARVFKKHALVAAGCFDRTVDGNESFRCGVTALKRIDSTEYLIAVQPQTDETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCW9</accession>
    <name>A0A132PCW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857769.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20144">
        <property type="protein sequence ID" value="KWX20144"/>
        <property type="gene ID" value="AFM11_31870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4700"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="402" mass="43248" checksum="9D2EE1B37B54C513" modified="2016-06-08" version="1">MTAPLAGLRVLDFAWIGAGALVTKALAELGADVIRIESRVRPDNLRQSPPFRPGTTGLDASGYFASRNPGKRSVALNMKHPKAREIALSLAARSDVFASNFRTGVLERWGMAYADVQQVNPRIVYLTMPMQGRDGPHHDYVGFGSTIAALAGLVHTTAAPGRPPIGTGTHYPDHVPNPGHALVALLAAIYHQQRTGEGQYVELSQLESTVNVVGHGIVHSSLGADVSPAGNHAPGCAPRGAYACADGEWLAVSCQTEEQWYALAKVVDRTDWLANPRFGTVLERLRNSDALDAELGEVLSARRRSAVVTELANAGVPAGPVNSSKDMLDDPHLSARGFWESVQHKVIGEVPMFHLPFRLDDGDRPSMSPPPLLGEHTREVATSVLELTDDEYEELVADGLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCZ6</accession>
    <name>A0A132PCZ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857977.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31655"/>
    <dbReference type="EnsemblBacteria" id="KWX20199">
        <property type="protein sequence ID" value="KWX20199"/>
        <property type="gene ID" value="AFM11_32195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4766"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PTHR10961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="3"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="382" mass="40971" checksum="5DCD00064A24FF84" modified="2016-06-08" version="1">MKCVVIGAGAWGLPTAAELVRRGHRVTLVDRYGPLNAESSSSGPTRLWRIADPDPVRVRMALRGIDAMERLAERSQSTVFLKRGLLWRDDESLPDLVAMMQRFDVDHTVVDDGDVATFFPGLRPDGRAAVWQPAAGVVLAEESLRAQERLFLAGGGMESFGRTVTGIGAGGNGVRVQFDDHTAEDADVVVVAAGPGTPRLLETIGVDLPLHPYLEQTVHFGDPENPTATDDHPCLFDGPRGDIPGIYAMPSPGIGYKIGLDLPLRPYDDADLDRTPDVMRTALLRDRVERDLTSVKPTVLGAHVCSWTDSPDGKFVIDALPDGVVLACGDSGEGFKYSALMGEVLADLAEGRTADPDVAAMSMARFEAGLPLHTGPHALGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDA7</accession>
    <name>A0A132PDA7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_31895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20207">
        <property type="protein sequence ID" value="KWX20207"/>
        <property type="gene ID" value="AFM11_31895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4705"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="412" mass="43669" checksum="F991F0039B683956" modified="2016-06-08" version="1">MSERVAGAWQRSVRSLRVRNYRLFFFGHAVSVAGTWMQRVAQDWLVYQITDSPIAIGVALALQFSPILVLGIWGGVLADRVDRRVALIVTQIVQLVLALVLGVLAIADVVELWMVYVLALLLGLVTVVDQPVRQSFVADLVDRDSYANAQVLNSTAQNLGKFAGPALAGGVIAWQGIGAAFLLNALSFVAMLVGLAMMRRQELLPQPRLQSARGQARAGIAYVFGHPQLRIAMLLLIVVSVLGQNFRVVFPLMGSMFGGGADAYGTLMAMVGLGALVAAVFTAARETATLRGLVVAAAAFGAVSCVLAGSRTLVFAFVATVALGITNFVFNTVVRTVMLLVSEPLMQGRVLALHGLVFLGSTPIGGLMIGWVCEHWGVRAGLLTGGLSVFAAALVAAAMLFNAKRNSNATNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDG0</accession>
    <name>A0A132PDG0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin-like protein NrdH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_30965</name>
        <name evidence="6" type="ORF">AWC31_26685</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Electron transport system for the ribonucleotide reductase system NrdEF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857222.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26685"/>
    <dbReference type="EnsemblBacteria" id="KWX20373">
        <property type="protein sequence ID" value="KWX20373"/>
        <property type="gene ID" value="AFM11_30965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14752">
        <property type="protein sequence ID" value="ORX14752"/>
        <property type="gene ID" value="AWC31_26685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4095"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011909">
        <property type="entry name" value="GlrX_NrdH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02194">
        <property type="entry name" value="GlrX_NrdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX14752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="79" mass="8569" checksum="6C2CC3899670BF33" modified="2016-06-08" version="1">MTVTVYTKPACVQCNATYKALDKQGIAYEKVDITLDSEARDYVMALGYLQAPVVVAGNEHWSGFRPDRIKALSSAAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDH2</accession>
    <name>A0A132PDH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20378">
        <property type="protein sequence ID" value="KWX20378"/>
        <property type="gene ID" value="AFM11_30990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4100"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046039">
        <property type="entry name" value="DUF5997"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19460">
        <property type="entry name" value="DUF5997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="120" mass="13240" checksum="81BB73F62A0ECDF3" modified="2016-06-08" version="1">MKPATAAKKLDVYLPATPAEFQENAITRAELAALQADPPQWLKDLRKNGPHPKNLVAAKLGVSIAGLARGGVTEALTTEQINQLLEEKPDWLVAERESYQNVLSEERRLKAVRAEQARES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDN5</accession>
    <name>A0A132PDN5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858088.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20072">
        <property type="protein sequence ID" value="KWX20072"/>
        <property type="gene ID" value="AFM11_32430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4814"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="199" mass="21179" checksum="428644CB4C96FD3C" modified="2016-06-08" version="1">MNLAVLGERIQSLRADRGLTLRELADRCHVSVSMLSSVERGDKAPTVVVLDRIAGGLGIPLADLVAEPDATRIVVRRAADQDRIDEPGGWQRTILSPVVPGVNFEWIRSTLPPGCDAGTFPAYASGSHEFVAVQSGTLTMTVGPHEVTLSAGDSIYFAADCPHGYANHGQTRCVYHVAALIMRPRGPGTGRAVTRPSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDP9</accession>
    <name>A0A132PDP9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856789.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20453">
        <property type="protein sequence ID" value="KWX20453"/>
        <property type="gene ID" value="AFM11_30200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3936"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="102" mass="11387" checksum="C1D5830D1A821054" modified="2016-06-08" version="1">MGVNLQFSADDLRQAATRYDRVADQIAAARAEHARAVAETETWGPLFYESRRAAVEAINKREQALLTEEKKNRDMATGLRTAAARFDNMTAENASNLTIRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDW9</accession>
    <name>A0A132PDW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20525">
        <property type="protein sequence ID" value="KWX20525"/>
        <property type="gene ID" value="AFM11_30195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3935"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019710">
        <property type="entry name" value="DUF4226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10774">
        <property type="entry name" value="DUF4226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="483" mass="47369" checksum="4AC797887AEBDA45" modified="2016-06-08" version="1">MKTGTDAGPGGNDAAPSPAPGSGKPPISPPAETTPQSNPAGDTELSGEAAEVAKRLDEALAKNRTALNEADEQLIDALLKAQDSSAEGKAKLTELQQSIIDQVQKLGPTLDTPAGQEQLASFLQGKTDEIHEVLKSKGLDSASQGAVLDGLAARYEALSGENPGEQNAPGDGAGAPSGAGPAPGAPGGSAPTDAGAAAAPGLGEDPMLSGLASDPLMAGLGSMLGPGMGALGSLPGMLGGMMPFGGGGAMGGGGLPLGDIGSGIGSAIRDAKAAGADTADPLTDPPVGDKPEAPGGDKDDQDKPGEVKDPPVGEGAQPNPAGAQAATNPADPQAQTGQVTPAGTGQPAPDDLTVKVPGSETPVTADNPAVAQAGRAVVSGTPIEQAYRDAGLSLSPPGAPITTNAVSQSRLAFGDVGQFTDHRIMALGNDKVWANGKAVALEDVDFGPTFLGWERPQAQAAAQPVVTASATTSPPTQTPPPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEB6</accession>
    <name>A0A132PEB6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_29010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20670">
        <property type="protein sequence ID" value="KWX20670"/>
        <property type="gene ID" value="AFM11_29010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3683"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="51"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="131"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="348" mass="37272" checksum="2B074A16A3F2D1A6" modified="2016-06-08" version="1">MIIRRALGRLSLTRPIEDYNKIAIGTVALVVMVAVVGAVALTGALNLGKTIYRAEFAQAASVREDDQVTIAGISVGHVDALTLAGDRVEMRLSIDKGVYLGSDTKAAIKLTTLLGSRYIELTPGRSGSLQGHTIPLSNTSAPYDLQTALADATTTFDQVDADQIANSLTTVSRSLDGLPQALPDALRNLKSLSRIISDRRGQIGTLLSSTDKLAATIRDQKANLGMLVLQGRDLIGEITTRRAAIERLFEGTTALAHTLSRILTDEHALNEMLDSVRDFTRMIAEHDALFRNTLQALPIAMRNIANATGSGTGIDGTFSSGPLIDSWMCAISGRAEQFGLVEYFEDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PED7</accession>
    <name>A0A132PED7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29760</name>
        <name evidence="6" type="ORF">AWC31_25100</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856541.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25100"/>
    <dbReference type="EnsemblBacteria" id="KWX20587">
        <property type="protein sequence ID" value="KWX20587"/>
        <property type="gene ID" value="AFM11_29760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14478">
        <property type="protein sequence ID" value="ORX14478"/>
        <property type="gene ID" value="AWC31_25100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3844"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="76"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX14478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="261" mass="28061" checksum="566345EFEBAACAB1" modified="2016-06-08" version="1">MAKEDVDSSGKQQTLLVLAKITEILNAFTLARPAMTLGEIQQATGLPTSTVQRLVSNMVAQGMLDRIGDQIRIGIRMSYWAATARKDVDVLAVVNPVLKEVRDKTGETACFFTVEQNFRVCVAVAETHHALRRDMYVGKVIPLHVGSASRVLLAWDPDLARRILSAPLEPMTEGTVTSADELAGLIAATRSDGYAITAGEREDSASGLSAPVFDSAGDILGALTVSGPTVRMPREQCEAWVDLVVGYAEQITRTLGGRPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-12-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEH4</accession>
    <name>A0A132PEH4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20736">
        <property type="protein sequence ID" value="KWX20736"/>
        <property type="gene ID" value="AFM11_29480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3787"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043733">
        <property type="entry name" value="DUF5677"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18928">
        <property type="entry name" value="DUF5677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="260" mass="29077" checksum="98A90A2230765812" modified="2016-06-08" version="1">MHKVARLESQYADRVDETETGWMTVVNVALDRWRTSWQEQTSTPELNPELSRKFRVCFPLAAHALNHVEAAVTLHSSSPWVAMSCVRIAFEHALTAQWVLWTKDGEDLLAQQMSLQDHRRSSEFIDAVVRAAADTPNLAESAALAEELSEFLGEKPVSVWSVFNLCERFSSTRLLYGIYRDLSQAVHPTYGLVRAHFDITPPPEVVVGPIRPFGAELDSPELIRGMAVSSLWALYVLEVSRAGHPDAAEVLRLASIRGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEP0</accession>
    <name>A0A132PEP0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_28310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32590"/>
    <dbReference type="EnsemblBacteria" id="KWX20754">
        <property type="protein sequence ID" value="KWX20754"/>
        <property type="gene ID" value="AFM11_28310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3536"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="83" mass="8733" checksum="E7CE24754472057B" modified="2016-06-08" version="1">MVRGLPRARTETGFRYGQIGSASLISLAHGTNDAQKTMGVIFLALISYGAASSSDTMPLWVVVACAVAIALGTYSGGWRIIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEP1</accession>
    <name>A0A132PEP1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856226.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32915"/>
    <dbReference type="EnsemblBacteria" id="KWX20808">
        <property type="protein sequence ID" value="KWX20808"/>
        <property type="gene ID" value="AFM11_28685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3618"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="27"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="236" mass="25892" checksum="19199CD215D845FA" modified="2016-06-08" version="1">MADRLYFRQLLSGRDFAADDMIAQQMRNFAYLIGDRETGDAVVVDPAYAAGDLVDVLEADGMHLSGVLVTHHHPDHVGGSMMGFTLKGLAELLERESVPVHVNTHEADWVSRVTGIAMSDLTRHEHGDKVSVGAVDIELLHTPGHTPGSQCFLFDGRLVAGDTLFLDGCGRTDFPGGDVDDMFRSLQALAQLHGDPTVYPGHWYSTEPSAPLDEVKRSNYVYRASNLEQWRTLMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEU8</accession>
    <name>A0A132PEU8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856327.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32600"/>
    <dbReference type="EnsemblBacteria" id="KWX20843">
        <property type="protein sequence ID" value="KWX20843"/>
        <property type="gene ID" value="AFM11_28320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3538"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="584" mass="58212" checksum="94D06E5D749B3E1A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEX0</accession>
    <name>A0A132PEX0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10160"/>
    <dbReference type="EnsemblBacteria" id="KWX20871">
        <property type="protein sequence ID" value="KWX20871"/>
        <property type="gene ID" value="AFM11_27625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3399"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="31561" checksum="0FE9BEFFD683198B" modified="2016-06-08" version="1">MPVTVDDDLDSLYRLRPEEFTARRKELAAAARKRGDTEGAKVIAAARRPTAAAWVVNLLALTDATVVPRLTELYDALRAAHTEMDGQRIRELSTAQRKLVQELSRAGFAAAELRDPTAALRDDVTATLQAAVADPEVAARLGRLSKAEEWSGFGDFGASAAVVTQTRPGTPSATARTTPQPSTKKPSRPNIAAVEEARRKRDAADSELNEARAAHDDALATVTERKDNVTTARRRYEKQLEALAAAERDLEAAAAQLDDAQRSADKLQKRVRTAESALMQAQSRLDRLADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFE6</accession>
    <name>A0A132PFE6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_27145</name>
        <name evidence="6" type="ORF">AWC31_06995</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855312.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06995"/>
    <dbReference type="EnsemblBacteria" id="KWX21055">
        <property type="protein sequence ID" value="KWX21055"/>
        <property type="gene ID" value="AFM11_27145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09938">
        <property type="protein sequence ID" value="ORX09938"/>
        <property type="gene ID" value="AWC31_06995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3304"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="106"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="446" mass="49463" checksum="7CE36682B640A74F" modified="2016-06-08" version="1">MDRQKEFVLRTLEERDIRFVRLWFTDVLGYLKSVAIAPAELEGAFEEGIGFDGSSIEGFARVSESDTVARPDPSTFQVLPWTSSSGQHHSARMFCDITMPDGSPSWADSRHVLRRQLAKASDLGFSCYVHPEIEFFLLKPGPDDGSVPVPADNGGYFDQAVHDAAPNFRRHAIDALEQMGISVEFSHHEGAPGQQEIDLRYADALSMADNVMTFRYVVKEVALGDGVRASFMPKPFAEHPGSAMHTHMSLFEGDTNAFHSPDDPLQLSDVAKSFIAGILEHASEISAVTNQWVNSYKRLVHGGEAPTAASWGAANRSALVRVPMYTPRKASSRRVEVRSPDSACNPYLTFAVLLAAGLRGVEKGYVLGPQAEDNVWSLTPEERRAMGYRELPSSLGNALEAMESSELVAEALGEHVFDYFLRNKRTEWENYRSHVTPYELKTYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFI5</accession>
    <name>A0A132PFI5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_27455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855477.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07390"/>
    <dbReference type="EnsemblBacteria" id="KWX21108">
        <property type="protein sequence ID" value="KWX21108"/>
        <property type="gene ID" value="AFM11_27455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3365"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="36049" checksum="2CED6362C1544E54" modified="2016-06-08" version="1">MKVKRPESAREADRRRVRQPARGAQRRNADAPPRKRRPSREQRPLRSAPQTGPIPRPRSGPVRPKSASQAKARAKARKAKAPKVVRPPLRERLLVRLASIELNPRELIARVPFVVLVIAALGVGLGITLWLSTGSAERSYQLGHARQTNEGLLQQKEALERDVLEAQAAPALAEAARNLGMIPSRDTAHLVQDPAGNWTVVGTPKPAEGVPPPPLNTPLPEEAPPPPPAPAAPRVVDPRELTVRVPQTGQPAGALPAVPPAEMPHGVPGAQPPAPGPVPLAAPLDVPAAQALPAPPEAPPVPAAPPVPETAQAPGAVHVPTPGVPIAPGPAPAVEQFTPATPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFZ2</accession>
    <name>A0A132PFZ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_26430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854915.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22885"/>
    <dbReference type="EnsemblBacteria" id="KWX21194">
        <property type="protein sequence ID" value="KWX21194"/>
        <property type="gene ID" value="AFM11_26430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3155"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="456" mass="46897" checksum="8DBB7190B2400BF9" modified="2016-06-08" version="1">MRQTHESDGGLGGFIRQSGYLRKWLILGISIGIIAGLGAVVFYLALDYAGRFLLGYLGSYDIPKPTGDGGDPGSAGFDRPWAIPLIACGGALVSALLVARFAPEAEGHGTDNAIEAVHTDPRSIRVRAIVVKTIASALTIGSGGSGGREGPAAQISAGFGSLLTRWLNLSDEDGRLAVSLGIGAGIGAIFGAPLGGAVLAASIVYREDFDYRALVPGFITSATAYAVLGSFLGFDPLFGFLAADYRFDHPLDLGWFVVLGVLAAGVGWLYARVFYGTVALTAKLPGGKVVKPTLGGLAVGLLALVIPQVLASGYGWAEKAAATDTLMAIPLWIVLLLPFAKILATSLSIGTGGSGGIFGPGVVIGAFLGAALWRLGDVLGAPGLPDSPAVFVVVGMMACFGSVAHAPLAVMIMVCEMTGSFSVIPCAMVAVGIAYLLISRTDVSIYRAQRLDRDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG27</accession>
    <name>A0A132PG27_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_26770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855168.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22565"/>
    <dbReference type="EnsemblBacteria" id="KWX21280">
        <property type="protein sequence ID" value="KWX21280"/>
        <property type="gene ID" value="AFM11_26770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3225"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1266"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1387"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1408"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1814" mass="194388" checksum="E283A3FA31E011B5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGD4</accession>
    <name>A0A132PGD4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_25715</name>
        <name evidence="8" type="ORF">AWC31_36180</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854491.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21324">
        <property type="protein sequence ID" value="KWX21324"/>
        <property type="gene ID" value="AFM11_25715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12051">
        <property type="protein sequence ID" value="ORX12051"/>
        <property type="gene ID" value="AWC31_36180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3007"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX12051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="446" mass="47645" checksum="00D8284A621A43C9" modified="2016-06-08" version="1">MTTTASRSDGPGARTPKRAALASFMGSAVEYYDFFLFGSAAALIFPHVFFPSDDEAALVMSFATFGFAYVARPVGAFILGHFGDRIGRQRVLMFTLVLMGLSTFLIGCLPSFDTIGWAAPALLVVCRLMQGLSAAGEQAGASSLTLEHSPDHQRAFFTSWTLTGTQGGLILASLVLIPFVSLPDEAKYGWGWRVPFWLSAVVVVVAYFIRRQLHETPQFTEAKAAGTIARVPLVPLLRNHWRDVLRVILCAFIAAVSTVFGNLAIAYGKKVGLDADVTLWLVVVANVVALGTQPMFGILADRIGRKPVFIYGALSSAALMPFYMLSMSGGNQLLTFALAVATFSFGYAAANAVWPAFYGEMFSTQVRFSGMAIGTQLGFLVAGFAPSIVTAMGGVREGGWVVISIFTAVVCLIAAGAALTARETKDIPTDMLGHKVPGSAKELVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGI2</accession>
    <name>A0A132PGI2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low molecular weight protein antigen 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854012.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27060"/>
    <dbReference type="EnsemblBacteria" id="KWX21440">
        <property type="protein sequence ID" value="KWX21440"/>
        <property type="gene ID" value="AFM11_24805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2322"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="132" mass="14119" checksum="3110F08036CBAA2B" modified="2016-06-08" version="1">MDSVSARSATAPVVIRISPMAHFAVGFFALGLLALVFTEPEWFAPLLVIPIALSVAIVRYRTVADADTVTARSLLGSETVPWSDIEGLRFDRASWAIAHRTNGSDLRLPGVTFATLPLLAEVSGGRVPNPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGL1</accession>
    <name>A0A132PGL1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-binding protein HU homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Histone-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_24975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854095.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27230"/>
    <dbReference type="EnsemblBacteria" id="KWX21470">
        <property type="protein sequence ID" value="KWX21470"/>
        <property type="gene ID" value="AFM11_24975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2356"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="212" mass="21641" checksum="5257BA49DE3065AD" modified="2016-06-08" version="1">MNKAELIDVLTTKLGTDRRQATAAVENVVDTIVRAVHKGDSVTITGFGVFEQRRRAARVARNPRTGETVKVKPTSVPAFRPGAQFKAVVSGAQRLPAEGPAVKRGVTAGPAKRTAAKKTAAKAPAKKAATKAPAKKAATKAPAKKAATKAPAKKAATKAPAKKAATKAPAKKAATKAPAKKAATKAPAKKAATKAPAKKAAAKKAPAKKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGS2</accession>
    <name>A0A132PGS2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854256.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21530">
        <property type="protein sequence ID" value="KWX21530"/>
        <property type="gene ID" value="AFM11_25320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2426"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="94" mass="9227" checksum="F6AF9FA4FA5217D7" modified="2016-06-08" version="1">MADTGSSARQFPAPGSAVPGAPPPLKRALTPADGVSVAIPREPASVASVPDATTTVGGTRFTAAAALLGVAVGLELAGVLSRAFATSRARKMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHE0</accession>
    <name>A0A132PHE0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853004.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27845"/>
    <dbReference type="EnsemblBacteria" id="KWX21746">
        <property type="protein sequence ID" value="KWX21746"/>
        <property type="gene ID" value="AFM11_23080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1968"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="243"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="402" mass="44590" checksum="7CC1ABD0D500F118" modified="2016-06-08" version="1">MESSHADRVDPVEPPIPIPDVPGADASSRGLPRRVDLTVRQRAIVDASAAADLVLRTGVASVVAASMVPRTLASIARPSGSRTEHEHMRFYADLAAAQDPAVSFPAPTEPPRVSSRPANPIAEWIAHGRVENIRFASSFTAVNPALRDQCAGFARNNVVRAQHWRHDDGPHPTLCVIHGFMGSPYLANGLFLSLPWFYRSGYDVLLYTLPFHGRRAEKFSPFSGHGFFAHGFGGFAEGMAQAVHDFRSIIDYLEFTGVDRIALTGISLGGFTSALLASVDDRIQAVIPNVPVVTPDRTVDEWFPANKLVALERFVARTDPALSEAATRYASPLNYRPLIAKERRLIITGLGDRLAPPQQAELLWEHWDRCAFHWFPGNHLLHVSQPDYLRRMTRFLRDFMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHL5</accession>
    <name>A0A132PHL5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853316.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28400"/>
    <dbReference type="EnsemblBacteria" id="KWX21848">
        <property type="protein sequence ID" value="KWX21848"/>
        <property type="gene ID" value="AFM11_23680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2092"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014512">
        <property type="entry name" value="O_gly_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021505">
        <property type="entry name" value="O_gly_hdrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="365" mass="40615" checksum="364A866D2077FB83" modified="2016-06-08" version="1">MDQLWANRAASAEAAITQRHLKKLWGLPGTQLGVVAWPSTKKYRNFGTWHYWWQAHLLDCLIDAQVRDPQPERKVRIERQIRAHWLRNTGWTNDYYDDMAWLALAIERAGRLAGVEKPRALKTLCDQLVNAWVPEDGGGIPWRKQDQFFNAPANGPAGIFLARYDDRLRRAQQMADWIDETLIDPDTHLVFDGIKAGSMVRAQYTYCQGVVLGLETELAVRTKDARHSERVRRLVAAVEKEMTTDGVIKGAGGGDGGLFNAITARYLALVATTLPGDAPEYVAARDTARSIVLKSAESAWDNRQTVDGLPLFSAFWDRTAELPSAAGKEAEFVEGAVNASAIPERDMSVQVSGWMLMEAAHTLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHS1</accession>
    <name>A0A132PHS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853419.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29895"/>
    <dbReference type="EnsemblBacteria" id="KWX21885">
        <property type="protein sequence ID" value="KWX21885"/>
        <property type="gene ID" value="AFM11_23750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2107"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="221" mass="23465" checksum="C019DC49858E7E7F" modified="2016-06-08" version="1">MSTPRAAAFAGVLFALLFGAALILIRTALPEGAQPGSQWADGAADRLRLAAVLMPFAGIAFLWFIGVVRDGFGRYEDRFFASVFLGSGILFLAMMFVSSAVGAGLIASKAGMVDADAHAEVVAFGQMLLMALSKTYGVRMAAVFMISLATIWLKTGLMPRPLVYSTYVAALALLIAGDVSMWLVLVFPCWVLAVSIWLLVRAGVIDLPGGDEPESVGKLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI22</accession>
    <name>A0A132PI22_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852836.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08415"/>
    <dbReference type="EnsemblBacteria" id="KWX21986">
        <property type="protein sequence ID" value="KWX21986"/>
        <property type="gene ID" value="AFM11_22785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1910"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="188"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="417" mass="44735" checksum="26D9AA3E2B482484" modified="2016-06-08" version="1">MSEVRRVEAVPHWRAAPLTKAIASASALVLVAAVAGSRWQLVVFAAPLLGVLCSVHWQRPAGRVEVCGEPAAVRCFENETVPVSVRVAAAPGTGCVLTVQPSRGMTVDVGAATSDRATVAAGATRWGRYPVRARVEVIPPGGLMVGEAIVEPAELYVFPLAAPQGTPIPRAELPDRLGTHLTRHTGPGVEYADVRPYVPGDHLRTVNWPVSARRGRLHVTERLTDRGADVVVLIDTHDQAPGPATQATERTARGAAQVVQSALRNGDRAGIVALGGRRPRWLGLDIGRRQFYRVLDAVLGVGSGFETTTGTLAPRAAVPPGAIVVAFSTLLSTEFALALIELSKRGHHVVAVDVLEGAPFDGELDPLIARMWALQRSAMYRDMSTIGVDVVHWRSDGPLQDAMRLIPDRHRHVHRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIA3</accession>
    <name>A0A132PIA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_21360</name>
        <name evidence="9" type="ORF">AWC31_04175</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0719 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852307.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04175"/>
    <dbReference type="EnsemblBacteria" id="KWX22065">
        <property type="protein sequence ID" value="KWX22065"/>
        <property type="gene ID" value="AFM11_21360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10505">
        <property type="protein sequence ID" value="ORX10505"/>
        <property type="gene ID" value="AWC31_04175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1619"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007140">
        <property type="entry name" value="DUF350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03994">
        <property type="entry name" value="DUF350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX10505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="151" mass="15594" checksum="B8D72AD283000406" modified="2016-06-08" version="1">MTTTTVALSSDYWSILGHGVSAIVLYTIVGIALMVLGFYVIDWTTPGPLRVLVQAGRPNAAAVAASGVLSMAIIIVLAIYASSGDLIQGLIMTLVFGLLGIAAQAFSVRLIGAIKGIDMGRVLAQETFTPEVLVITAAYLAFGLIVAAAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIF1</accession>
    <name>A0A132PIF1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04635"/>
    <dbReference type="EnsemblBacteria" id="KWX22138">
        <property type="protein sequence ID" value="KWX22138"/>
        <property type="gene ID" value="AFM11_21830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1714"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="169" mass="17731" checksum="651582E4EB459C8B" modified="2016-06-08" version="1">MSRPILGSSCARAASAAEMRYRIDRPIRGRNGARIIGLDAGADAIVERIAHEPWGHARFLSLAERVGDAGDRGSESVSLRDTAGDVSSLLVELEDADVVIMVATTDADTAAATIVGAACTVRAIMTAALVIGDRERIGATVATLRPHARVLMVSGDERDVVDLLTALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIG9</accession>
    <name>A0A132PIG9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_23000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852987.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22054">
        <property type="protein sequence ID" value="KWX22054"/>
        <property type="gene ID" value="AFM11_23000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="178" mass="19053" checksum="D27E48D885DEB43F" modified="2016-06-08" version="1">MADAVLSVLVADGFEGVSVRKVAALAKVSIGAVQHHFPTKDAMLAAAMDRASARFLARLGERLSPDAPAAQRLEDLAVALVCPDPRDRDISVAWLLRLARAAVDEQTAARHREDWARVAKWLAESIAAAAPGVDADLAAVELLALLDGLACSVAIEPDRVSAELAERIAREHVRRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIL1</accession>
    <name>A0A132PIL1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_21625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852383.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04430"/>
    <dbReference type="EnsemblBacteria" id="KWX22104">
        <property type="protein sequence ID" value="KWX22104"/>
        <property type="gene ID" value="AFM11_21625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1673"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="202" mass="21790" checksum="4DA54A7AE88A093A" modified="2016-06-08" version="1">MPRPRSFTADQIAAAALAVVDADGLAALSMRTVARRLGIGTMSLYRYVADRDELEVMVVDLVLARVDLRVPRGEPASQLTELAERVRDAAARHPAVVPLVLIHRHRAPASLRWGEVVLGVLTDAGCTGKRRVYAFRAVLAYVFGALAVEQYGALAGPGTQALAELPADQFPLLSETAQTARDIGPVEEFRRGLDVLLRGLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIM4</accession>
    <name>A0A132PIM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852543.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22186">
        <property type="protein sequence ID" value="KWX22186"/>
        <property type="gene ID" value="AFM11_22095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1767"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="290" mass="30040" checksum="8AB1D3A3AD127D71" modified="2016-06-08" version="1">MGALEGRVAVITGAGRGIGREHALLFASEGASVVVNDLGGSNSGDGADAGPAHEVVAEIRAAGGNAVANTENIATWDGAQSLVQQAIDEFGRLDVVVNNAGILRDCFIPTMTESDWDAVIAVHLKGHFSVLRHAAEYWKAQSKAGDQPMASVINTASGSGTTIPNAGQANYGSAKAAIAALTLVAADELERYGVRVNAIAPIARTRLTLATPGMGALMAEPEDEGEVDLFSPANISPLVAYLATEKCPITGRVYAVQGGAISQLAGWHDVETIETDGLWRIDDIAERLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIP9</accession>
    <name>A0A132PIP9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ThrE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853410.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28200"/>
    <dbReference type="EnsemblBacteria" id="KWX21882">
        <property type="protein sequence ID" value="KWX21882"/>
        <property type="gene ID" value="AFM11_23475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2050"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="2">
        <location>
            <begin position="13"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="407" mass="43207" checksum="1EBE8C8AF1F7A5CE" modified="2016-06-08" version="1">MAEPLDERSAAVRFIARLGSAMLGADYPVPIVRRTLDTIAEQYRIDCPLLVLPNFIQAGDRGQTTVLRREDPLRYDQTFPLGELIRRATLGQVTPEEGWAELDRIHTLSRRFPSWVGILGYAVQSAAYALMLQPTLVALVAASGFGLLVGLLEWATRHNSGLRQLLPVLSAFLVTYVAFTLGRLLHMGHDSLRVLIPPLTLFLPGVAITLSVIESSTGDMVSGSARLMAGFLRLAQLALGIVIAIQLLGLSSPELTDASVNTLGPWAPWLGVAVYAVGIVLHLGPPPGFAKWLVLVLFITYGAQLATAAAFGGYTSGFGGGLALMLCALALGRLPMTPAAQVILAPGFWLLVPSSVGLIGIAELAGGQGSNAIIVMLVSMMSIALGFATGLAIWSGIMRRGDANLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIT7</accession>
    <name>A0A132PIT7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hrcA</name>
        <name evidence="7" type="ORF">AFM11_20675</name>
        <name evidence="8" type="ORF">AWC31_06090</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852040.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06090"/>
    <dbReference type="EnsemblBacteria" id="KWX22256">
        <property type="protein sequence ID" value="KWX22256"/>
        <property type="gene ID" value="AFM11_20675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09788">
        <property type="protein sequence ID" value="ORX09788"/>
        <property type="gene ID" value="AWC31_06090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1472"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="105"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX09788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="343" mass="36676" checksum="4CD903130E0784A5" modified="2016-06-08" version="1">MSSADDRRFEVLRAIVADFVATKEPIGSKTLVERHNLGVSSATVRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRIDNVKPLSSSERRAILNFLESGVDLDDVLRRAVRLLAQLTRQVAIVQYPTLSTSTVRHLEVVALTPARLLLVVITDTGRVDQRIVELGDAIDDHELAKLREMLGQALEGKPLTAASVAVSDLATHLNGSDGLADAVGRSATVLVETLVEHAEERLLLGGTANLTRNTADFGGSLRSVLEALEEQVVVLRLLAAQQEAGKVTVRIGHETEAEQMAGTSVISTAYGSSGKVYGGMGVVGPTRMDYPGTIANVAAVALYIGEVLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIY5</accession>
    <name>A0A132PIY5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_20960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852140.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06380"/>
    <dbReference type="EnsemblBacteria" id="KWX22306">
        <property type="protein sequence ID" value="KWX22306"/>
        <property type="gene ID" value="AFM11_20960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1533"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="36892" checksum="1D9D5356B8FF253A" modified="2016-06-08" version="1">MADVPSPSYAFASDNAAPAHPQVIEAITAANDSAVASYGDDAATQRATEAVRTTFDSPDADVLFALTGTGANIIALASAVRPWQEILCSDVAHSLVDEAGGPVRLSGAQLTKLPSDDGLIDPAELDRAVTRRGPVHHSQPRIVTITQSTENGRLWTPQAIKDFIDHAHDLDLLVHVDGSRIANAVAALDIPPREAIGDADIVTVGGTKNGLLLGDAILVRRPELFDGIHFVQKQIGHLASKQRFIAAQFEALFRDGLWLRNADHANHMAARLSVGFESLGLRLASPTEANEVFVDLDPREYHQLSTAYAVHRPDPLLPTVRFVCSWATTEREVDDVLSLLGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ00</accession>
    <name>A0A132PJ00_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_22815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852850.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08385"/>
    <dbReference type="EnsemblBacteria" id="KWX21992">
        <property type="protein sequence ID" value="KWX21992"/>
        <property type="gene ID" value="AFM11_22815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1916"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="208" mass="21869" checksum="D5FDC269CE53BA88" modified="2016-06-08" version="1">MLDYIRDAAEIYRQSFATIRNEAELSRFPADVSRVVVRLIHTCGQVDVTEHVAYTDDVVVRTHAALAAGAPILCDSSMVAAGITRSRLPADNEVVSLVADSRAPELAARLGSTRSAAAVDLWADRLDGAVLAIGNAPTALFRLLELLDDGAPTPAAVLGGPVGFVGSAQSKQELIDRRRGMSYLVVTGRRGGSAMAAAAVNAIASERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ09</accession>
    <name>A0A132PJ09_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-3' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852979.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08335"/>
    <dbReference type="EnsemblBacteria" id="KWX22002">
        <property type="protein sequence ID" value="KWX22002"/>
        <property type="gene ID" value="AFM11_22865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1926"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="307" mass="32391" checksum="C442B130E5456F26" modified="2016-06-08" version="1">MWFRSYFGVPSSIKAPDGRPVNAVRGFLDSIATLVGRERPSRLVVCRDDDWRPQWRVELIPSYKAHRVAEPEPDGVPDIEEVPDELTPQVGMIMELLDAFGIPTAGAAGFEADDVLGTLAGREQRDPVVVVSGDRDLLQLVRDEPKPPVRVLYIGRGLAKAVKFGPAEVAEQYGVPVERAGAAYAELALLRGDPSDGLPGVAGIGEKTAASLLARFGSLSAIQAAADDPKSSLSKAHRTKLLAAADYIAAAEPVVRVATDAPVKMSTPTDALPLAAGDPGRVAELAAAYGVSSSISRLQTALDQLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ48</accession>
    <name>A0A132PJ48_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06655"/>
    <dbReference type="EnsemblBacteria" id="KWX22379">
        <property type="protein sequence ID" value="KWX22379"/>
        <property type="gene ID" value="AFM11_21280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1602"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAP_DH_C" evidence="1">
        <location>
            <begin position="142"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="352" mass="37620" checksum="0F1B722D5FA25B30" modified="2016-06-08" version="1">MVWGTGFVGSMVIAEIVRHPLFELVGVGVSNPEKVGRDVGEICGLGAPIGITATDDVDALIALRPDALVHYGPTAAHADANIALITRFLRAGIDVCSTAMTPWVWPKMHLNPPNWIEPITEACEAGGSSCFTTGIDPGFANDLFPMTLMGLCSEVRRVRASELLDYTNYTGDYEFEMGIGKPPEHRPLLESPDILIFAWGATVPMIAHAAGIELDAITTTWDKWVTPDERKTAKGVIAPGNVAAVRFTINGVYRGETRIQLEHVNRIGPDAAPDWPSGNDNDVYRVDIEGTPSISQETAFRFTDGSGRDAAAAGCLATGLRALNAVPAVNEHSPGWVTALDLPLIPGVGTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJN7</accession>
    <name>A0A132PJN7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19830</name>
        <name evidence="3" type="ORF">AWC31_11170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX09037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851849.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11170"/>
    <dbReference type="EnsemblBacteria" id="KWX22407">
        <property type="protein sequence ID" value="KWX22407"/>
        <property type="gene ID" value="AFM11_19830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09037">
        <property type="protein sequence ID" value="ORX09037"/>
        <property type="gene ID" value="AWC31_11170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1300"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015837">
        <property type="entry name" value="UCP026622_CAAX_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026622">
        <property type="entry name" value="Proteas_026622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="254" mass="26567" checksum="85B6682ACCF8C912" modified="2016-06-08" version="1">MSDSSAVAAHPHPLVAQLSALHHFRIYADIGIVVVILTLTNLIAHFTTPWASVATVPAAAIGLLILVRARGLGWAELGLGREHWRSGVGYALAAVALVVSVIAIGTMLPWTRPMFMNDNYATISGALLASMVIIPLQTVIPEELAFRGVLHGALNRAWGFRGVAAGGSLLFGLWHIASSLGLTSENVGFTRLFGGGVFGMVAGVVLAVVATGVAGFVFTWLRKRSGSLIAPIALHWSLNGVGALAAALVWHLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJU8</accession>
    <name>A0A132PJU8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851980.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22534">
        <property type="protein sequence ID" value="KWX22534"/>
        <property type="gene ID" value="AFM11_20150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1365"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453133" evidence="2">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="136" mass="13123" checksum="A97DCE8853594B0F" modified="2016-06-08" version="1">MKKLVVLGGGLVAAGSIALFAAGTATSEPTAASINVVGEPYMKALSILKSQGVKATFGGSFGSALPQAECLVDSQKVNSSGKMILMLDCSAEAAEQAADNAVSGGPRVGGNGVTTVTPTPVVPIAGAPGAGTPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJX4</accession>
    <name>A0A132PJX4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851663.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15315"/>
    <dbReference type="EnsemblBacteria" id="KWX22635">
        <property type="protein sequence ID" value="KWX22635"/>
        <property type="gene ID" value="AFM11_19235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1181"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453361" evidence="1">
        <location>
            <begin position="27"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="34"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="308" mass="31479" checksum="15FCDB88F458A386" modified="2016-06-08" version="1">MKIQRITALLGVSLTAVAVLAGCATAADSGKPTIGVTLNAASNPFFLAEGKAIEEAAAEAGVEVSVQYANADVAVQSDQIDTFIRKKVDSIIVDAVDSDGVGPAVLRATQANIPVVAIDVAAPGAAATVTSDNVQAGRDSCAYLFDQLGGKGKVAIVDGSAVSAISDRMDGCRQAIEKTPGIEIVATQRADLTRDKSMNVASNILTAHPDIQGFFGVNDPTAVGISLAAQQRGSAVKVVGVDGAQQLTDLIGQGHIIGTSGQDPAKLGRTGLDLAVKLANGEQVSSEPQRIPTFLVTAETIGDYQKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK00</accession>
    <name>A0A132PK00_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851718.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15475"/>
    <dbReference type="EnsemblBacteria" id="KWX22661">
        <property type="protein sequence ID" value="KWX22661"/>
        <property type="gene ID" value="AFM11_19390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1211"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="6"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="316" mass="33328" checksum="6A3E8E7C8DB4556B" modified="2016-06-08" version="1">MLDLGPLVLGTMTFGDTVDADGAAAMLDAALDAGITHIDTANGYAGGESERILAELLRGRRDKVTLATKAGIPHPDAGDHAPLSAAGLRAGIDGSLSRLRTDHVDLFYLHQPDRATPLTETLGTVAELVREGKIGALGVSNYAAWQIAELNHVADTVGAPRPVAAQQLYNLLARRIEEEYVEFAAVTGLTTVVYNPLGGGLLTGRHTYGTEPAEGRFGDSRLARMYKQRYWNTAIFDAIEALGVVADKAGLPLTELALRWLVSKPATGPILLGGSKVSHLQSNIAAVSKGPLTDDVVAACDDVGSALRGPMPNYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK40</accession>
    <name>A0A132PK40_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851784.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15695"/>
    <dbReference type="EnsemblBacteria" id="KWX22701">
        <property type="protein sequence ID" value="KWX22701"/>
        <property type="gene ID" value="AFM11_19630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1259"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="498" mass="53938" checksum="E6ADD372CDA7FEA7" modified="2016-06-08" version="1">MTPSQILDIAAAAFGQLLRRAGVATSPAEVIEVRRVLGLLGARDLTALRAALRATCAKYGREQRGFDRAFDAMFGAMNVAHHEPGVGPSRAHTGSGLPDQLEIDENQEIGRYAEYNERAAEVGDHFDTPEADKGFNPHKDDDDFSVTGADNQLTVSAETDSGRRGVRYTVEVDRAASSMAGDLADSVAPVVAGGLHWDDPESILAWLDAYDPTRTYGEDAGDQPLTAEQLSQLSQAVEGFVAALADRCGLAAEPEGPDGPADVGLAADIDLACHEVLRRMRGAPRARPRERGRGRLDMRRTTRASLRTDSVPFHLVMRTPLPDRIRLLVIADVSLSVRPVTAFTLRLAQAMHRRAHRCRVMAFVDRPVDVTEILLRAGGDDALAAVLAETQLDLEASSDYGQVFDEMLAGQADALDSRTAVLVVGDGRSGGLPSGVERLRALRRRVHRVAWVTPEPTRYWRQATCAMPEYAQVCDKVVVARDAEQLTARAGELAHALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK67</accession>
    <name>A0A132PK67_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851703.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15435"/>
    <dbReference type="EnsemblBacteria" id="KWX22654">
        <property type="protein sequence ID" value="KWX22654"/>
        <property type="gene ID" value="AFM11_19350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1203"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="25304" checksum="8EAB39FE707F0B84" modified="2016-06-08" version="1">MSRPTLVFLHGVGLDHTVWGPVTDLLPGFEVITPDLPGHGARPAAPAGVTLADLADGVADEIPAGSHLVGFSLGALVAQHLAVHRPELVASLTSVSSVCRRTDEERAAVLGRLRTAEKDFAASAAASLSRWYDGTDVDPEQVARTEATLLANDPASFVNCYRVFATADAEIAPQLSRIDVPALAITGSDDPGSTPDMTYRLAAAIPECEAVVVTGARHMLPVQCPRALADALTSFIGRSVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK88</accession>
    <name>A0A132PK88_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851044.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04975"/>
    <dbReference type="EnsemblBacteria" id="KWX22745">
        <property type="protein sequence ID" value="KWX22745"/>
        <property type="gene ID" value="AFM11_17455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.846"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="151" mass="16601" checksum="56397587C92F9A8F" modified="2016-06-08" version="1">MPGIAELALGAAPIAGGAMLGVIAGNLKPPDVRGMIAKDMDLLERLPAEDVELRARLKANIDERISDLIAAGERSRELREAAMSYRGNWRDIVVFICALLFTFIWWNVSHSRANWLAMFIAMIIVSVAAGIYAGRGVLRAVRTFLHRNDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKA6</accession>
    <name>A0A132PKA6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851039.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04960"/>
    <dbReference type="EnsemblBacteria" id="KWX22743">
        <property type="protein sequence ID" value="KWX22743"/>
        <property type="gene ID" value="AFM11_17440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.843"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="155" mass="17533" checksum="43139F24D4FA3CA0" modified="2016-06-08" version="1">MSESARSLRIQLLIGFMCLALVVYFLMLGRTALAFITSGEPAAIGLGLALLVFPLIGVWVLFSTLRAGFAHQRLARLARERGMELDVSALPRRPSGRIERDAADELFVTVKTELEADPDNWVRWYRLARAYDYAGDRTRARETMRTAVRMQEQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKE6</accession>
    <name>A0A132PKE6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15500"/>
    <dbReference type="EnsemblBacteria" id="KWX22734">
        <property type="protein sequence ID" value="KWX22734"/>
        <property type="gene ID" value="AFM11_19415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1216"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453347" evidence="1">
        <location>
            <begin position="37"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="98"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="525" mass="57283" checksum="517C143F40F50B69" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKI4</accession>
    <name>A0A132PKI4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemE</name>
        <name evidence="13" type="ORF">AFM11_18135</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851274.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12205"/>
    <dbReference type="EnsemblBacteria" id="KWX22851">
        <property type="protein sequence ID" value="KWX22851"/>
        <property type="gene ID" value="AFM11_18135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.984"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="30"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX22851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="353" mass="37357" checksum="0CE99475818642D1" modified="2016-06-08" version="1">MNTRRELPSSPYLAAVSGRTPHRVPVWFMRQAGRSLPEYRELRAQHRMLQACFDPELVCEITLQPVRRHGVDAAILFSDIVVPLKAAGIGLDIVPDVGPVIDNPIRTIADVQGMRPLEPQQVSPISDAVKLLVSALGDVPLIGFAGAPFTLASYLVEGGPSRHHERTKAMMLGEPATWHALMSALTDLTIAFLQAQVDAGVDALQVFDSWAGTLSLADYRSYVLPHSSRVFATMAAAGVPMTHFGVGTAELLGAMSEALGSAPAKVVGVDWRTSLVDAAARVVPGTALQGNLDPVVLLAGWPVVEPAVRQVVEDGRRAVAAGAAGHVFNLGHGVLPASDPGIITEAVTLVHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKW1</accession>
    <name>A0A132PKW1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850652.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22981">
        <property type="protein sequence ID" value="KWX22981"/>
        <property type="gene ID" value="AFM11_16520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.653"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="103" mass="11642" checksum="0965A8AB34B060D9" modified="2016-06-08" version="1">MIRHVFAWKVVDQQDAGKVIELLTEYSASQEAVRHFEIGGHTGDPGDNGDPWDGVLITDFDDWEGLQVYSDHPDHVKLVEVLLPMVKERAVIDFVRQEGVTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKX6</accession>
    <name>A0A132PKX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_17500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851403.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05020"/>
    <dbReference type="EnsemblBacteria" id="KWX22904">
        <property type="protein sequence ID" value="KWX22904"/>
        <property type="gene ID" value="AFM11_17500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.855"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="35"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="308" mass="34217" checksum="A1C7812A61CE9AA2" modified="2016-06-08" version="1">MLSRMPRSTRMVPFREYETWVQVTTPENAKPDALPLFVLHGGPGMAHNYVANIAAIADETGRTVVHYDQLGCGNSTHLPDAPAEFWTPELFVEEFHTVRTALGIDRYHVLGQSWGGMLGAEIAVAAPEGLVSLAICNSPASMQLWVEGAAELRAQLPPEIQSALQRHEADGTVTDPEYLAATQEFYRRHVCRTDPMPQDFADSEAQMEAEPTVYHTMNGPNEFHVIGTLRDWSIVNRLPSITAPVLVVAGEFDEATPATWQPYVELIPDVRSHIFPDTSHCTHLEKPEEFRAVIAEFLQQHDLAAARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL49</accession>
    <name>A0A132PL49_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16475</name>
        <name evidence="3" type="ORF">AWC31_19845</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850637.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19845"/>
    <dbReference type="EnsemblBacteria" id="KWX22974">
        <property type="protein sequence ID" value="KWX22974"/>
        <property type="gene ID" value="AFM11_16475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16317">
        <property type="protein sequence ID" value="ORX16317"/>
        <property type="gene ID" value="AWC31_19845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.644"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="121" mass="12930" checksum="A9D04F411D040DAB" modified="2016-06-08" version="1">MAELGDWVHIDPDAEKPLFDQLRVQIIDGIRDGRLSPGTRLPTVRELAGQIGLAVNTVARSYRELESAGVLETRGRYGTFVARADPADAAMAAAANSFAEAARALGIGKSDALRYLDGAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL67</accession>
    <name>A0A132PL67_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase DeaD</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cold-shock DEAD box protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">deaD</name>
        <name evidence="6" type="synonym">csdA</name>
        <name evidence="13" type="ORF">AFM11_17190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850895.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01755"/>
    <dbReference type="EnsemblBacteria" id="KWX23095">
        <property type="protein sequence ID" value="KWX23095"/>
        <property type="gene ID" value="AFM11_17190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.791"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070417">
        <property type="term" value="P:cellular response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12499">
        <property type="entry name" value="RRM_EcCsdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00964">
        <property type="entry name" value="DEAD_helicase_DeaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034415">
        <property type="entry name" value="CsdA_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028618">
        <property type="entry name" value="DEAD_helicase_DeaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="12">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="52"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="250"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="452"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX23095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="580" mass="63544" checksum="D3FAE2EDE06FC700" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLB7</accession>
    <name>A0A132PLB7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein LprC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850985.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02005"/>
    <dbReference type="EnsemblBacteria" id="KWX23136">
        <property type="protein sequence ID" value="KWX23136"/>
        <property type="gene ID" value="AFM11_17420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.838"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="186" mass="19559" checksum="9429155C8D4F9C27" modified="2016-06-08" version="1">MSSQNKLGRGIATVAAALAVFAGLTGCTRTVDGTAAREGTGGGPSNNNSEKQYPNLLKECDVLTDDILAETVGADPLDIQSTFVGAVCRWQAANPAGLVDITRFWYEQGSLDNERQTAQQLQYQIEQRRVQGVESIVMKPNGLNGACGVASDAAGVVGWWVNPQAPGIDACSMAVKLMELTLATNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLF5</accession>
    <name>A0A132PLF5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease subunit beta</fullName>
            <ecNumber evidence="4">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureB</name>
        <name evidence="5" type="ORF">AFM11_15240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the urease beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850157.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15860"/>
    <dbReference type="EnsemblBacteria" id="KWX23181">
        <property type="protein sequence ID" value="KWX23181"/>
        <property type="gene ID" value="AFM11_15240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7161"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008223">
        <property type="entry name" value="Urease_gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001225">
        <property type="entry name" value="Urease_gammabeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="24861" checksum="A71703138BC6D6AA" modified="2016-06-08" version="1">MHLTPKEEDRLLLFLAAELARKRRAKGLRLTYAEARAVIADEVMEAARAGASVSEAAAIGAAVLTDDDILPGVATLVGTVQVEGFFEDGQKLVTIHDPIRPGTQALPAEPQPGEVIVADGDIELNTGRDVTEVSVVNTGDRPVQVGSHFHFFEVNRALRFDRARAFGMHLDIASGTAVRFEPGEERVVTLTQFGGAREISGLNDMATGLMGRPDEALTRLRDNGFADSGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLV2</accession>
    <name>A0A132PLV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850129.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15780"/>
    <dbReference type="EnsemblBacteria" id="KWX23167">
        <property type="protein sequence ID" value="KWX23167"/>
        <property type="gene ID" value="AFM11_15160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7144"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="53"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="27752" checksum="D21C3A1D57D61B3B" modified="2016-06-08" version="1">MTRDFDALVAEAAAAPVDGWDFSWLAGRATEQRPSWGYQRLMGQRLAQVSSALDIQTGGGEVLAGAEKFPLTMAATESWPANVARATRLLGPRGVVVVATPDDPPLPFGDAAFDLVVSRHPATVWWAEIARVLAPGGTYFAQHVGPASVFELVEFFLGPQEQARMKRHPDDETAAARTAGLDVVDVRSERLRMEFGDIGAVVYFLRKVIWTVPDFTVEAYRDRLHALHRRIEAGGPFVAHSSRHLIELRKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMH5</accession>
    <name>A0A132PMH5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849961.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18075"/>
    <dbReference type="EnsemblBacteria" id="KWX23538">
        <property type="protein sequence ID" value="KWX23538"/>
        <property type="gene ID" value="AFM11_14825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7076"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="24321" checksum="6360C0D43563AEB4" modified="2016-06-08" version="1">MNGSPHPVPSDGLTPDLLAELQAGLLDDATAARVRQQVRSDPDAAATLAALDRVRRDVAALGTDEASAPAVPPDVSARMIAALRAAGGRAESDRSRGRWRRIGAITGCCAALLGAGVGAATLTQTSDTADSSPTSLGRMTVAPPPADVGLSEPEILGLLSAPPDLGPLADPQRRAQCLSALGYPSGVRVLGARPHAVTGRPGVLVLLPADTPNAIVGLVVTPDCDAAHTELLADTVVKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMI3</accession>
    <name>A0A132PMI3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09445"/>
    <dbReference type="EnsemblBacteria" id="KWX23407">
        <property type="protein sequence ID" value="KWX23407"/>
        <property type="gene ID" value="AFM11_14025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6909"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="16"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="330" mass="34666" checksum="3B0B629643FC80B2" modified="2016-06-08" version="1">MTGTSAMRAIVLDGFGGLDRLVYTDIPKPEPKAGEVVIQIKGFGVNHAEMHMRRGEWAEAAKVSGIECVGIVDSCPGGEFPVGAKVAALMGGLGRTINGSYAEYTRVRAANVALIESDLPWAALAALPETYATAWTCLFRNIDLQSGQTLVVRGATSSFGQAAVKLAVGAGAHVIATTRNPDRFALLENLGAARAEKEVPDLSAHIAESGEIDAVLDLVGNSTILDSLDMLRRGGTACLAGWLGGLDPIPDFNPLLRMASGVNLSFFGSFVFGSPGFPLSDVPLVDIARQVADGRLEAAPSRVFSFDEIREAHRVMEAGEAGGKMVVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMV0</accession>
    <name>A0A132PMV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12625</name>
        <name evidence="3" type="ORF">AWC31_02905</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848996.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02905"/>
    <dbReference type="EnsemblBacteria" id="KWX23645">
        <property type="protein sequence ID" value="KWX23645"/>
        <property type="gene ID" value="AFM11_12625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11098">
        <property type="protein sequence ID" value="ORX11098"/>
        <property type="gene ID" value="AWC31_02905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6615"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="278" mass="28530" checksum="2D5AA68DC3C098D4" modified="2016-06-08" version="1">MSSVDAEQLFCGTTLARRIERAEAQLIVAATEAARGRGAEGLVLPVAGGFACFADAGSPMNKVVGLGFDGVPDEAVLGEIERALAGRGAATQVELSNLADPEVAGLLTGRGYRLAGFENVLGRPVGAEDLPAPAGLEVRRAADVAAWVDVVVDGFAHPDAEGVPSHEEFPRDVIERAELDMEKAGAAPYIAVVDGTVAGGGAVRFTDGIAQLCGAATVPAYRRRGVQTALLAARLADAAAAGCDIAVVTTAPGSKSQQNVQRRGFQLLYTRAVLVKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN58</accession>
    <name>A0A132PN58_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_13010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849180.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03295"/>
    <dbReference type="EnsemblBacteria" id="KWX23704">
        <property type="protein sequence ID" value="KWX23704"/>
        <property type="gene ID" value="AFM11_13010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6695"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="28804" checksum="F0959AC0B5823B5D" modified="2016-06-08" version="1">MPGSTLFTDAMALTAAGDGVYDGHLNEHWTIGPKVHGGAMLALCANAARTEAGGGAQPIAVSGNFLWAPDPGPMRVVTTVRKRGRRISVVDVELNQGDRTAVSASVTLGEPEHHVPPLLSFNPVVPLMTPEPPPGLEPIGPGHPMEHIVHLAHGCDIRPALHTLGPRTDGGPPVFEYWVRPKGVAPDVLFALLCGDVSAPVTFAVERTGWAPTVQLTAFMRALPADGWLRVMCTSVQIGQDWFDEDHIVVDCEGRIIVQTRQLAMVPAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNI0</accession>
    <name>A0A132PNI0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849635.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03970"/>
    <dbReference type="EnsemblBacteria" id="KWX23899">
        <property type="protein sequence ID" value="KWX23899"/>
        <property type="gene ID" value="AFM11_13725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6841"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="248" mass="25536" checksum="E5220554FFA33747" modified="2016-06-08" version="1">MALGSSMAAGPGIKPSADGAPFRAGRSARNYPHLVADRLGLDLVDVTYSGATTAHVLHDKQNGAPPQIDALDGSEALVTVTIGGNDVGYVPLLMAAGLPRVLRAVPVLGPRLRDLLDADAREAALTHVAGSLAEVGRIIRERAPRATVLFVDYLTLLPPTGGAAPLSDDHAELGRHIADTLERHTGAAAAETGCGWVRAAQASIAHHAWSAEPWTTRPGLPIPGRPAPLHPNAAGMRAVADLVAAHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNU2</accession>
    <name>A0A132PNU2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_11575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848312.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24000">
        <property type="protein sequence ID" value="KWX24000"/>
        <property type="gene ID" value="AFM11_11575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6392"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="381" mass="41707" checksum="1875624E78CDA8BA" modified="2016-06-08" version="1">MPKVDATNSVEISDLEKEFVRQHSGETVRVIDGVSFTVPKGSFFTLLGPSGCGKTTTLRCLAGLETADRGEIRMNGQVVYSAEERCDIASSVRPIGMVPQSYGIWPHMKVFDNAAFPLRYGRKTYPRPEIEKRVLAMLDKVGLAEYSDRWSTQLSGGQQQRLALARALLCEPEVLLLDEPLSNLDAKLRSQLRGELRSFQQDFGVTTIYVTHDQAEALSMSDTIVVMNRGRIEQIGSPGEIYDSPASRFVADFVGSANLISGVVDTTACSGDRVVDVKTTVGVLRSERFTAPPTPPTAGQEISVCVRPENIRISTTGPDAEDSNQFLATVTSIEYLGDRKELQVTAGDLTLRTHGDAHLDVRPGDEVTVALDPRWTVALWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP73</accession>
    <name>A0A132PP73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-demethylubiquinone-9 3-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848699.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09680"/>
    <dbReference type="EnsemblBacteria" id="KWX24130">
        <property type="protein sequence ID" value="KWX24130"/>
        <property type="gene ID" value="AFM11_12300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6539"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="163" mass="17841" checksum="BE714AAB221ABF27" modified="2016-06-08" version="1">MTEINASIVPNLWFDREAEQAAEHYIAAFGGNGRITNTIAAQPNSPSPQDVPLVVEFELAGQRFVGINGGPQFKFTEAVSLEVRVTGQDELDRLWAALVEGGQEQPCGWLKDKFGLSWQITPTEYYDLLDKGDAAGEERLMAAVMSTMGKFDIAKLQAAYNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPY9</accession>
    <name>A0A132PPY9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847692.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19005"/>
    <dbReference type="EnsemblBacteria" id="KWX24400">
        <property type="protein sequence ID" value="KWX24400"/>
        <property type="gene ID" value="AFM11_10570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6154"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="402" mass="43175" checksum="38F092E813C010A9" modified="2016-06-08" version="1">MTAPLEGIRVLEVAMYGFVPSAGAVLGEWGADVIKVEHAVTGDPQRGLRQTGPLRVEGDPNPNIEHANRGKRSIGLDMSVPEGREVLLELARRADVFLTSFLPGHRQKFGIDVDDIRAVNPNIIYARGSALGPRGEESVKGGYDMTAFWCRAGTAATITPAGMEGMIAPPGPAYGDTISGTNLAGGIAAALLKRERTGEPSVVDVSLLGSGLWSMGHTVALTQHLNQLMVTPPPGVHGSPINPLVGLYGTADDRYISFVMMQPTKFWADVCKHMDLERYIDDPRFATAESFAENTPAAVEILTEAMKKRTLPEWSERFATLAGPWAPVQDTLQAGQDAQIRANEYLVEAGELELVANPVQFDVTAPRTGPAPGFAEQTDDILVELGLDWDRIIELKTAGAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ29</accession>
    <name>A0A132PQ29_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847762.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19230"/>
    <dbReference type="EnsemblBacteria" id="KWX24423">
        <property type="protein sequence ID" value="KWX24423"/>
        <property type="gene ID" value="AFM11_10715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6183"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="333" mass="34164" checksum="EE5B10FC5207DE69" modified="2016-06-08" version="1">MKAAVCRQYGPPEAVRVEELPSPVLAPGRLRVRVGAAAVNFPDVLLVADQYQVNVPVPFVPGSEFAGVVTEVAPDTVDFAVGDRVTGTGMFGAFAEEVCVGSAALAKIPDSVDDRTAAAFGVAHRTAYHTLRSVAQVRPGDDVIVLGAGGGVGLAAVQLGVTLGARVTAVASSDEKLCVAARYGASVLVNHATGPVRTTLREALPAGAHAVIDPVGGELSEPALRSLRRGGRFVTVGYASGSIPQIPLNLVLVKGIQIVGFQFQDIPPDEFARNESELRELLATGGVKPHIGAVYPLAETAAALRHVADGQAIGKVVIDVGYALPSALGSFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQB8</accession>
    <name>A0A132PQB8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847681.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18990"/>
    <dbReference type="EnsemblBacteria" id="KWX24397">
        <property type="protein sequence ID" value="KWX24397"/>
        <property type="gene ID" value="AFM11_10555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6151"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="27542" checksum="88D503EC5924B638" modified="2016-06-08" version="1">MADRWSIGVPLVRNLSGPMQAVGALFAMSLDAIRFAFRRPFQGREFLDQCWFVARVSMAPTLLVAIPFTVLVSFTLNILLRELGAADLSGAGAAFGAVTQLGPMVTVLIVAGAGATAMCADLGSRTIREEIDAMEVLGINPVQRLVTPRILASGLVALLLNSLVVIIGILGGYVFSVFIQDVNPGAFAAGITLLTGVPEVIISCVKAALFGLIAGLVACYRGLTIVGGGAKAVGNAVNETVVYAFMALFVINVVVTAIGIRMTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQJ0</accession>
    <name>A0A132PQJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_07930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846192.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24530"/>
    <dbReference type="EnsemblBacteria" id="KWX24601">
        <property type="protein sequence ID" value="KWX24601"/>
        <property type="gene ID" value="AFM11_07930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5436"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="157"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="434" mass="44973" checksum="0A6B07835C3083A3" modified="2016-06-08" version="1">MRGFFADTTPLRSPDFRRLWLAGIPTVIGANLTIFAVPVQLYALTQNSAYVGLSGLFALVPLIVFGLWGGAWADAMDRRLLLIIASIGLAVSSVLLWVQAAAGLDNVWVVLCLLSVQQAFYAINSPTRSAAIPRMVPGEQLPAANSLNMTVMQFGAIVGPLLAGLLLSWVDLSTLYLIDAITCLAPIWATVRLAPMPPTSTEQGSARWGFTAVLDGFRYLAGNRVVLMSFVVDLIAMIFGMPRALFPQMAHESFGGPVEGGTVMALLAAAMSAGAVLGGVFSGWLPRIRRQGLAVVVAIVAWGVAMVGFGLAGGLAGGTAGTFLWIALVFLAIGGAADIVSAAFRSTILQQAASDELRGRLQGVFTVVVAGGPRLADTLHGAAAAAVGTTVAAAGGGALVVVGVVIAALVVPAFVRYRVAGFAARDDQSEPDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQJ6</accession>
    <name>A0A132PQJ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846121.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24575">
        <property type="protein sequence ID" value="KWX24575"/>
        <property type="gene ID" value="AFM11_07785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5408"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="281" mass="29883" checksum="B2654CF45DE8A061" modified="2016-06-08" version="1">MNRKLRVSAVTPDIVIGDLDGNLARLHTALRAIEWVRPHLAVLPELATSGYVFADVDEARGLALRADDARLTALADDVPADCVAVVGFAEADGDTLYNSAIVIGDGRVFGTYRKAHLWAAEPEVFATGVEAGTVIDTPICRLGVAICYDNEFPELPRRLALRGAEVLALPVNWPLADRPEGEHAPETIQAMAAARSSQLATVISDRRGTERGVRWTGGTAVIGPDGWIKAAPQGDETIATAVLDLTDSKTIGDLNDALADRRPDLYGDLVESGGVVTDIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQP9</accession>
    <name>A0A132PQP9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18850"/>
    <dbReference type="EnsemblBacteria" id="KWX24372">
        <property type="protein sequence ID" value="KWX24372"/>
        <property type="gene ID" value="AFM11_10415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6122"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="PTHR36840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="439" mass="47302" checksum="8EB0B95DF465DD5D" modified="2016-06-08" version="1">MRAAAFPRANRKGTDQVNDSEPKLPVRAHRLNRMAGRDPHEQHRVATPLELLFDLTFVIAFGVAASQLAHLMAEGHVGAGLVAFGFASFAIWWAWMNFTWFASAFDTDDWVYRAMTMLQMVGVIILALGLPQMFASVEHGGHVDNTVLVAGYVVMRVALVGQWLRAAKQDPEHRSACLTYAAAVVVAQIGWIVQIFAHTSVLVFFLSAAVLVVVEMSGPFLAERRMGGTPWHAHHIAERYGLLAIIALGEGVVGTVASLTAAVGEQGWSTDAILLVIAGTGLTFGMWWVYFLVPAAELLHAHRRLSFWYGYLHLVVFGSIVATGAGLHVAAYYIEDHSELDSVATVLAVAIPVGIYLVGMFVIYSVLVGEIDVLHTGLLVLAGVVLGAAVAMASAGISMALCLLVVTGAPVVVVVGYEVIGHRHARRIVARRLADQREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQV1</accession>
    <name>A0A132PQV1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_08545</name>
        <name evidence="6" type="ORF">AWC31_13820</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846509.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13820"/>
    <dbReference type="EnsemblBacteria" id="KWX24706">
        <property type="protein sequence ID" value="KWX24706"/>
        <property type="gene ID" value="AFM11_08545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18385">
        <property type="protein sequence ID" value="ORX18385"/>
        <property type="gene ID" value="AWC31_13820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5558"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="154"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX18385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="277" mass="30915" checksum="8EFD91EC665C8A2F" modified="2016-06-08" version="1">MARSDVLVTTDWAESNLKAPKTVFVEVDEDTSAYDTGHIEGAVKLDWKTDLQDPVRRDFVDAQQFSKLLSERGIANDDTVILYGGNNNWFAAYAYWYFKLYGHNDVKLLDGGRKKWELDARPLSTDKVERPQTSYTAKDPDNSIRAFRDEVIAAIGAKNLVDVRSPDEFSGKILAPAHLPQEQSQRPGHIPGAINVPWSKAANEDGTFKSDEDLAKIYADAGLDGEKETIAYCRIGERSSHTWFVLQELLGHKNVKNYDGSWTEYGSLVGAPIELGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQV4</accession>
    <name>A0A132PQV4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08530</name>
        <name evidence="3" type="ORF">AWC31_13835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846500.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13835"/>
    <dbReference type="EnsemblBacteria" id="KWX24703">
        <property type="protein sequence ID" value="KWX24703"/>
        <property type="gene ID" value="AFM11_08530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18388">
        <property type="protein sequence ID" value="ORX18388"/>
        <property type="gene ID" value="AWC31_13835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5554"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453252" evidence="1">
        <location>
            <begin position="33"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="271" mass="28191" checksum="0DAFC4E09F778953" modified="2016-06-08" version="1">MGNNVPVRKLLIGVVATVAALVVGAVGTDFGAAIYAEYRLARNVRSAAGLNWDPAVAILGFPFITQARNHQYKEIEIRAGAVEHPVVGKASLEATLHDIDITEASWLIRPDAPMHVSKAESRIIIDSTHVGRFMGIDDLLVEAPARETNDATGGTTESGISSNKGLVFTGTPKASGLDERVSVAVDLSITGPDQTTLVLTATGILTGPGTADEPVPADKTAAVLAEFSSTITGQKLPFGIAPTSAGARGSDVIIEGIAEGVTIDLEGFRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRC8</accession>
    <name>A0A132PRC8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="5">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PNP/PMP oxidase</fullName>
            <shortName evidence="5">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdxH</name>
        <name evidence="10" type="ORF">AFM11_07935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24535"/>
    <dbReference type="EnsemblBacteria" id="KWX24602">
        <property type="protein sequence ID" value="KWX24602"/>
        <property type="gene ID" value="AFM11_07935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5437"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="8">
        <location>
            <begin position="50"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="9">
        <location>
            <begin position="190"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5 6">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="78"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="233" mass="25945" checksum="4AA71EF885EC235B" modified="2016-06-08" version="1">MAIPDDGRQDADLAAMRVEYVEKDGHGDLDVDWLGDDPATGWLTLLRTWLSEAHQARVAEPNAMVVATVDERGRPVTRSVLCKSVDQTGITFYTNYDSAKGEQLAANPYASATFPWYQLGRQVHVRGPVTKVAAEATAEYWSKRPRGSQLGAWASQQSRPIDSRAALMEQLAEVTERFAELDEVPVPPNWGGYLIAPEVVEFWQGRENRVHNRIRIEGADALADGCRVERLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRM8</accession>
    <name>A0A132PRM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_06025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845174.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29635"/>
    <dbReference type="EnsemblBacteria" id="KWX24989">
        <property type="protein sequence ID" value="KWX24989"/>
        <property type="gene ID" value="AFM11_06025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4397"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="16"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="559" mass="58447" checksum="DCBE265C92C2B00D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRS9</accession>
    <name>A0A132PRS9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_08765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846602.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13605"/>
    <dbReference type="EnsemblBacteria" id="KWX24742">
        <property type="protein sequence ID" value="KWX24742"/>
        <property type="gene ID" value="AFM11_08765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5601"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="479" mass="50953" checksum="813B52FF42D641DD" modified="2016-06-08" version="1">MSRPETVEQQPQLRRVMGPGLLLLFVVGDILGTGVYALTGQVAKEVGGAAWLPFLVAFLIATITAFSYLELVTKYPQAAGAALYAHKAFGIQFVTFLVAFVVMCSGITSASTASRFFAVSFFDAIEQIFNHVFTWEKIGVVLIALLFMAVIAAVNLRGVTESVVLNVILTIIEITGLAIVILVGLWAILSGADVDFGRVVAFETAEEKNAFLAVTAATSLAFFAMVGFEDSVNMAEETKDPVRIFPKVLLSGLGIAGVVYVVVAVIAVALVPVGELAAANSPLVKVVETAAPGLPFQQILPIISMFAVSNTALINMLMASRLIYGMARQHVLPPVLGTVAPRRRTPWVAIVFTTLIAFGLIFYVSAFASSNAISVLGGTTSLLLLAVFATVNVAVLVLRRDVREDGSHFKTPTILPVIGFIASLYLVLPTSGRPAQQYFLAIALIIIGVVLFLVTMAINRQLGIRGPGMIDPTHLSDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRT6</accession>
    <name>A0A132PRT6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_06330</name>
        <name evidence="9" type="ORF">AWC31_29345</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845267.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29345"/>
    <dbReference type="EnsemblBacteria" id="KWX25043">
        <property type="protein sequence ID" value="KWX25043"/>
        <property type="gene ID" value="AFM11_06330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13960">
        <property type="protein sequence ID" value="ORX13960"/>
        <property type="gene ID" value="AWC31_29345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4460"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004377">
        <property type="entry name" value="ABC_transpt_DrrB/DrrC"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00025">
        <property type="entry name" value="Mtu_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX13960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="261" mass="27108" checksum="F9912A5C63669B4A" modified="2016-06-08" version="1">MATDRFAPGTFTPDPRPATVQKMLAAQFGLELRLLLRNGEQLLLTMFIPITLLIGLTLLPLGSFGEDRAGTFTPAIMALAVISTAFTGQAIAVAFDRRYGALKRLGATALPVWGIIAGKSLAVVAVVFLQAILLGAIGVALGWRPPLAGLALGALIIALGTAGFAALGLLLGGTLRSEIVLALANLLWFVFAGLGALTLEGQDGQAIPTAVAWAARLTPSGALTESLTQAMTLSVDWFGLAVLAVWGAVAAVCALRWFRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRZ5</accession>
    <name>A0A132PRZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06825</name>
        <name evidence="3" type="ORF">AWC31_28825</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845465.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28825"/>
    <dbReference type="EnsemblBacteria" id="KWX25128">
        <property type="protein sequence ID" value="KWX25128"/>
        <property type="gene ID" value="AFM11_06825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13796">
        <property type="protein sequence ID" value="ORX13796"/>
        <property type="gene ID" value="AWC31_28825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4564"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="443" mass="47856" checksum="230A0DED4B645C07" modified="2016-06-08" version="1">MDLGSAANATGAEWIGCAPHEELDRTARPQLPSDDVFYLPPAGFHHAEPGTVLRSRDVEVAFLGLIPQRFHATQLLYRSTDRHGAPEAAVTTVIVPPDAKPDCPIVSYQCAIDAISNRCFPSYALRRHAKAAGSLAQLEFLLITAALAEGWAVSVPDHEGLDGMWGTPYEPGYHVLDGLRAALNCEQLSLTDASPIGLWGYSGGGLASAWAAEMSGSYAPELNIVGAVLGSPVGDLGHTFRRLNGTVFSGLPALVVAALADTYPGLNRVIAEHATTEGRKLLRRLHDMSTVEAVVRLARTDMDDLVDLPLEQILDSAEVTEVFDDIKLGVATPNPPVLIIQAVHDELISVDDIDELADAYLAGGADVTYHRDLFSEHLLLHPMSAPMALRWLTDRFADRPLSEHLVRTKWPTLLNPMTYVGMARLGRIALKVATGRAIGRRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS55</accession>
    <name>A0A132PS55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_07170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845649.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17545"/>
    <dbReference type="EnsemblBacteria" id="KWX25188">
        <property type="protein sequence ID" value="KWX25188"/>
        <property type="gene ID" value="AFM11_07170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4634"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="262"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="493" mass="52602" checksum="478B39D88FC46281" modified="2016-06-08" version="1">MDLLLGIDMGTGSTKGVLVDASGSVIATETVPHSMDLPRPGWAEVDAEQLWWREVCQISSALMAQLPSGGRLAGMCVSGVGPCLVLCDDAMRPLRPAILYGIDTRASAEITELTDELGEAAILQRAGTLLSSQAVGPKLEWVRIHEPDVFERATGWYGSNSYIAAKLTGEYVMDHHTASQCDPLYATREFEWNVPWAQRICGHLPLPRLVWPSDVVGTVTPQAAAATGVPVGTPVSAGTVDAYSEAFSVGVRRPGDQMLMYGSTMFLVQIIGEYHSDPALWTTTGVEHDTLALAAGTSTAGSLIGWLQTVTGGASFDELMAEASSVPPGSEGLLVLPYLAGERTPVFDPQARGVVAGLTLRHGRGHLFRAAYEGISFGIRQILERFDDAHTGARTVAVGGGLRSPIWAQALSDITGRPQLVPEQAIGASYGDALLAAIGVGLVAPDTDWAKIATEIKPDARYRGLYDDLYATWRELYPATKDQVHRLAAQPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSE4</accession>
    <name>A0A132PSE4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_07255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845920.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25271">
        <property type="protein sequence ID" value="KWX25271"/>
        <property type="gene ID" value="AFM11_07255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4651"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="461" mass="49360" checksum="F0FC3137E3D09D41" modified="2016-06-08" version="1">MADKRSPDRPASARELRKIVTASSLGTLIEWYDFYIYGSLAVVFSGMFFPEGNTAAALLVTVAAFGTGFVVRPIGAVVFGRMGDRVGRKKTFLTTLLIMGGATTLLGLLPTYEHIGLAAPLLLVLLRLLQGLAIGGEYGGAAIYIAEHAPKRRRGAVTSFLQTTATGGLVLSIGVIVSCRLIVGEEQFEAWGWRIPFLLSAVLVLFSLKVRLKMHESPVFEEMRQNGRLSQTPVKDAVAQRPTLILLLTVLFGVTAGLGVAWYTSQFYSLYFLQSILQVDFLTANLCVGIALVVATPFFVVFGWLSDRIGRPPVILTGLVLSAAGCYPLFAWVRQAAIDGDEVSMVVALILQVVLVAAIYGPVAAFLTELFPPQIRYTGLSLAYHLGTGVFGGFTPLIALSLNTSLDSAMAGLIYPIAVTAVTAVIFVVFLRRGHASPIVARAWAATDVAGTSAPTRMSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSI4</accession>
    <name>A0A132PSI4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="11" type="ORF">AFM11_05985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845161.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29675"/>
    <dbReference type="EnsemblBacteria" id="KWX24982">
        <property type="protein sequence ID" value="KWX24982"/>
        <property type="gene ID" value="AFM11_05985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4388"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PriA_3primeBD" evidence="10">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX24982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="666" mass="71046" checksum="7A8A97F4252BAFDE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSJ9</accession>
    <name>A0A132PSJ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_06105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845197.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25002">
        <property type="protein sequence ID" value="KWX25002"/>
        <property type="gene ID" value="AFM11_06105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4413"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="215" mass="23682" checksum="783C11E31B2BEBD0" modified="2016-06-08" version="1">MPHDEDQRPRRLTRAENQARTRALLLDAAARTFARKGYAAASVDEIAATAGFSVGAVYSNFSGKEQLFSELMAERASGRIDQVVDTLAEGRRETGEPLRALGRMLIEIADKDIEFEAIQSEFWLQAVRNPDAMQILVDRSARTLASVRDIVAEALERNNVDDSVSPDAFAVVVLALFQGLIRQRRIDPDRVPEELFGQALAWQIAGMPKASAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSM2</accession>
    <name>A0A132PSM2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannitol ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_03280</name>
        <name evidence="7" type="ORF">AWC31_21805</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843926.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21805"/>
    <dbReference type="EnsemblBacteria" id="KWX25323">
        <property type="protein sequence ID" value="KWX25323"/>
        <property type="gene ID" value="AFM11_03280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16654">
        <property type="protein sequence ID" value="ORX16654"/>
        <property type="gene ID" value="AWC31_21805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2531"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX16654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="288" mass="31476" checksum="4B08A2EC7C93D520" modified="2016-06-08" version="1">MTTTEVQKPVETPVRKAKVKRRKFDPWGAVAWIVGLGFVFPVFWMVLTAFKQEVDAYTATPKLFFVPTLDQFKAVFEQGVGTALLNSLFATTVSTILVLALGIPAAFALSLRPVRKTQDALFFFMSTKMLPIVAAIIPLYVIVSNIGLLDNIWGLVILYTAMNLPIAVWMMRSFFLEVPGELLEAASLDGASTWRSVREVILPLVSPGIAATALICVIFAWNEFFFAVSLTAVQAQTMPVYMVGFIAGQGLYWAKLCAAATMAALPVVLAGWIAQNKLVRGLSFGAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSS1</accession>
    <name>A0A132PSS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_03805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844209.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21360"/>
    <dbReference type="EnsemblBacteria" id="KWX25401">
        <property type="protein sequence ID" value="KWX25401"/>
        <property type="gene ID" value="AFM11_03805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2637"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="382" mass="40807" checksum="EEB2E41A57C0E8AA" modified="2016-06-08" version="1">MSIWTTPEREALRKTVRAFAEREVLPNVDEWERTGELPRELHRKAADAGLLGAGFPESVGGGGGDGADAVIICEEMHHAGSPGGVFASLFTCGIAVPHMIASGDERLIETYVKPTLRGEKIGSLAITEPGGGSDVGHLTTKAVQDGDDYILNGAKTYITSGVRADYVVTAARTSGPGAAGVSLIVVDKGTPGFEVSRKLDKMGWRSSDTAELSYTDVRVPVANLVGAENSGFLQIAAAFVSERVGLAAQAYSSAQRCLDLTVEWCRNRETFGKPLIARQSVQNTLAEMARRIDVARVYTRNVVERQLAGETNLITEVCFAKNTAVESGEWVANQAVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTSLAAKTLGFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSU4</accession>
    <name>A0A132PSU4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase</fullName>
            <shortName evidence="3">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purN</name>
        <name evidence="6" type="ORF">AFM11_03650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844124.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21505"/>
    <dbReference type="EnsemblBacteria" id="KWX25380">
        <property type="protein sequence ID" value="KWX25380"/>
        <property type="gene ID" value="AFM11_03650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2605"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453258" description="Phosphoribosylglycinamide formyltransferase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="3">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="3">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="210" mass="21917" checksum="221828308793F70A" modified="2016-06-08" version="1">MQQPLRVPPSAPARLVVLASGTGSLLASLLAAAVDDYPGRVVAVGTDRKCAALDIAADAGVTSYTVRLGDYPDRAAWDAAITAATAEHQPDLVVSAGFMKILGPQFLSAFPGRVVNTHPALLPSFPGAHAVPEALAYGVRVTGCTVHLVDAGMDTGPILAQQVVEVADDDTEETLHERIKVVERRLLVDVLAALATRGVTWTGRKATFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT06</accession>
    <name>A0A132PT06_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_07075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845618.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25172">
        <property type="protein sequence ID" value="KWX25172"/>
        <property type="gene ID" value="AFM11_07075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4614"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041467">
        <property type="entry name" value="Sco4008_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17926">
        <property type="entry name" value="TetR_C_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="187" mass="20574" checksum="F0164A4FCF2BA857" modified="2016-06-08" version="1">MVRDAEATRQRLLEAARDEFATYGIAGARVDRIAAAAQSNKAQIYHYFGNKDGLFDAVFDDMCRVTLDEVPIDATDLPEYAGRLFDSYRRRPWVQRIATWYRLERASTADLLPIVVASNTAKIEAISAAQRAGTLPDRFAPSVLLGLVLHLSGFWSSNTPEFDAAVDIASPDAQRRVVVDAVAALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT07</accession>
    <name>A0A132PT07_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdpC</name>
        <name evidence="12" type="ORF">AFM11_04310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844462.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20845"/>
    <dbReference type="EnsemblBacteria" id="KWX25481">
        <property type="protein sequence ID" value="KWX25481"/>
        <property type="gene ID" value="AFM11_04310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2740"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX25481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="29953" checksum="18119B4479CCB77E" modified="2016-06-08" version="1">MQFTNLIRQHAAALRALLVLTVILGVAYPVFIWLVAQLPGLNHKADGSIVEADGKPVGSSLIGQLFTDADGNPLPQYFQGRPSAAGDGYDPMATSASNLGPESIVDQPGKPSLLTLVCQRSQAVGEFDGVSGARPFCTGDGVGAVLSVIGPRDSRGNVIHPTRVVSVNEPCDTTKTPFLNTYEGVRVECAQAGEDYSAGQIVPIHGSADAQVPADAVTASGSGLDPHISPAYADLQVNRVAEARGLAPEQVRQLVAQHTDGRTLGFLGEPRVNVLELNIALDTLSAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT77</accession>
    <name>A0A132PT77_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_06430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29245"/>
    <dbReference type="EnsemblBacteria" id="KWX25252">
        <property type="protein sequence ID" value="KWX25252"/>
        <property type="gene ID" value="AFM11_06430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4478"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="486"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="826" mass="88861" checksum="D685F41C26CD157F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT79</accession>
    <name>A0A132PT79_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844610.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20410"/>
    <dbReference type="EnsemblBacteria" id="KWX25549">
        <property type="protein sequence ID" value="KWX25549"/>
        <property type="gene ID" value="AFM11_04735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2828"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="122" mass="13007" checksum="658B270E42392422" modified="2016-06-08" version="1">MSRIDAVLEAARARLDRLPAADVPAALADGAVLVDIRPAAQRAREGEVDSALVIERNVLEWRCDPTSDARIPQAVDDDVYWVILCSEGYTSSLAAASLLDLGLHRATDVIGGYHALVANGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTL4</accession>
    <name>A0A132PTL4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844877.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25681">
        <property type="protein sequence ID" value="KWX25681"/>
        <property type="gene ID" value="AFM11_03815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2639"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="159" mass="17608" checksum="0C12AA81F9B9EAD1" modified="2016-06-08" version="1">MGEALEPEQLHTYFALMEAVSLLQHAVAQQLRAEGDLSYVQFQLLAKLVDADKPLTMTELADGVVYSRSGLTHQAGLLEKAGLIQRRHSTDDQRATLVSITKSGRALVAKVLPGHIEVTRSLLFDPLSERDLRTLGDIMTRARDHMRSLPPRSARRSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTT1</accession>
    <name>A0A132PTT1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_00145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842075.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33255"/>
    <dbReference type="EnsemblBacteria" id="KWX25749">
        <property type="protein sequence ID" value="KWX25749"/>
        <property type="gene ID" value="AFM11_00145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.30"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="322"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="394" mass="41586" checksum="5D702DF57182A657" modified="2016-06-08" version="1">MTSSSQSGGVVIVGGGLAAARTAEQLRRSEYPGAITIVSDEDHLPYDRPPLSKEVLRAETDDVTLKPAEFYAENNITLRLGSAAQSVDTAAKTLKLADGSEIGYDELIIATGLVPKRIRSFPDLAGIRVLRSYDESMALREDAGKARRAVVVGAGFIGCEVAASLRKLGVDVVLVEPQPTPLASVLGETIGALVTRLHEAEGVDVRCGVGVTEVRGSDHVEQVVLGDGTELDADLVVVGIGSHPAVDWLEGSGIELDNGVVCDEVGRASAPHVWAIGDVASWRDHVGDQARVEHWSNVADQARALVPALLGQESSAVVSVPYFWSDQYDVKIQCLGEPEADDVVHVVEDDGRKFLAYYERDGVLVGVVGGGMPGKVMKARGKIAAGAPISDILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU50</accession>
    <name>A0A132PU50_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00805</name>
        <name evidence="3" type="ORF">AWC31_33845</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842436.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25866">
        <property type="protein sequence ID" value="KWX25866"/>
        <property type="gene ID" value="AFM11_00805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11666">
        <property type="protein sequence ID" value="ORX11666"/>
        <property type="gene ID" value="AWC31_33845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.165"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="165" mass="16965" checksum="666BEDF40E7DC613" modified="2016-06-08" version="1">MMAVYLAAFVVGGVALLSALLLADIGHGDGMPFLSLTGVSAALVGAGTGGLIGTWVGMETFATALLAGACAVVLVFVLNGVLLPYLRRQQSNSHKGRSSYIGLLGTVTLEVPAGGWGEVSFVDADGNRVFSRAKSDEPAALPKSTRIYIADIDSDFVHVVAVPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU64</accession>
    <name>A0A132PU64_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842462.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33905"/>
    <dbReference type="EnsemblBacteria" id="KWX25878">
        <property type="protein sequence ID" value="KWX25878"/>
        <property type="gene ID" value="AFM11_00870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.180"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="137"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="183" mass="20403" checksum="4FA56A057DD4059F" modified="2016-06-08" version="1">MLFTYDTELTLRAAAVLVNSDRVDGDQLADLAALDAYLDHFGWTGRRDRDAAELSAVQGLRVRLGEIWGAAEDEEVAVALVNGLLGDTKASPWLTRHPEMPDWHLHLASADDPLWQRMGAEMAMALADLIRGGELRRLKICAAPDCEAVLTDLSRNRSRMFCDTGNCGNRQHVAAYRQRQREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU87</accession>
    <name>A0A132PU87_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_01055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842567.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25909">
        <property type="protein sequence ID" value="KWX25909"/>
        <property type="gene ID" value="AFM11_01055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.216"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="58"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="28214" checksum="93FA601A09CC9397" modified="2016-06-08" version="1">MDRLTGWVAKAALVFLYVPIVAVVVYSFNASETSSRWGGFSVKWYGEVFTDRALLKTLQTSFTVGAIAAAVATTVGFLTAFGLARYRVKGRTLFLGAVLLPLVLPEIVLGAALLTVFSTVQLPLGIPTIVLGHIVISLPLTTLILMGAISSLDSSLSEASADLGCTPWQTFIRVLFPLLRSSIFAAFLLAFTTSFSNIVISTFTSGVGSTTLPLRIYSLLKTGITPEINALGAMLIVATVLLIFAVGIQQMRRILVGYENAGQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUL1</accession>
    <name>A0A132PUL1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 6">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_00760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 6"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842408.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33800"/>
    <dbReference type="EnsemblBacteria" id="KWX25857">
        <property type="protein sequence ID" value="KWX25857"/>
        <property type="gene ID" value="AFM11_00760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.156"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="331" mass="37008" checksum="FA50C9B9DE04351B" modified="2016-06-08" version="1">MRLLVTGGAGFIGANFVHLALHEALTTSVTVLDALTYAGSREALAPVADRIQLVQGDITDAKLVGDLVREADAVVHFAAETHVDNALADPEPFLRANVIGTFTVLEAVRRHGVRLHHVSTDEVYGDLELDDPARFTETTPYNPSSPYSSTKAAADLLVRAWVRSYGVRATISNCSNNYGPYQHVEKFIPRQITNVLTGRRPKLYGTGANVRDWIHVDDHNSAVWRILADGRIGQTYLIGAECERDNLTVMRTLLRLMDRDPDDFDHVPDRAGHDLRYAIDPSTLHDELGWAPKHTDFDEGLRATIDWYRDNESWWGPLKDAVEANYRERGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV43</accession>
    <name>A0A132PV43_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_01135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843599.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26229">
        <property type="protein sequence ID" value="KWX26229"/>
        <property type="gene ID" value="AFM11_01135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.233"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX26229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="196" mass="20871" checksum="BA4437698B73A9E1" modified="2016-06-08" version="1">MTEALSLINEGGLESLTMRRLADRLNAHLPTIYRLVDGKDALMDEMAETILANAMSDFPPDSTDWAAQVKSLAAGLRSALLAQRDGARIVGGNYAAKSANLTFTDTLVGRMQAIGLVGEHALWAAGAVFCYVLGEVLEQQGATGGELETLEGVLHAGSYPHLASSPVDHLLDFDARFEFGLNLLVSGIRFGLKPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV45</accession>
    <name>A0A132PV45_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ethanolamine ammonia-lyase small subunit</fullName>
            <shortName evidence="4">EAL small subunit</shortName>
            <ecNumber evidence="4">4.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">eutC</name>
        <name evidence="5" type="ORF">AFM11_01015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ethanolamine = acetaldehyde + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15313"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="EC" id="4.3.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
        <text evidence="4">Binds between the large and small subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amine and polyamine degradation; ethanolamine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.7" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842543.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34045"/>
    <dbReference type="EnsemblBacteria" id="KWX25902">
        <property type="protein sequence ID" value="KWX25902"/>
        <property type="gene ID" value="AFM11_01015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.209"/>
    <dbReference type="UniPathway" id="UPA00560"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008851">
        <property type="term" value="F:ethanolamine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00601">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009246">
        <property type="entry name" value="EutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042251">
        <property type="entry name" value="EutC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042255">
        <property type="entry name" value="EutC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39330">
        <property type="entry name" value="PTHR39330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05985">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018982">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1 4" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="2 4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="26881" checksum="9BBE0C3376882E4D" modified="2016-06-08" version="1">MSTNNPAVQDFWDDLRKTTQARIGLGRAGNALPTRQVLELAAAHAAARDAVHVPLDTEKLAAEIRDIGIGEPIVVTSRATSRDEYLRRPDLGRTPAADMDVPESGADIGFVLADGLSPTALSHHGAGLLTELVARLADRHTLAPPVIATQARVALGDHIAAQMRCRTVLVIIGERPGLSVADSLGIYLTHLPMPGRTDADRNCISNIHPPDGLGYAEAARIAAGLVDGALALGRSGVDLKDTSRTAALGPSGATELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAY5</accession>
    <name>A0A132PAY5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peripla_BP_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000046">
        <property type="protein sequence ID" value="KWX19478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859902.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31590"/>
    <dbReference type="EnsemblBacteria" id="KWX19478">
        <property type="protein sequence ID" value="KWX19478"/>
        <property type="gene ID" value="AFM11_35675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5870"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452959" description="Peripla_BP_6 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="35"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="419" mass="44335" checksum="3D8A098E97D0EFC6" modified="2016-06-08" version="1">MDRLGTAVRKLSAMAVAVATGAALVGCGDGDGTAVIGVAAPLSGEAAVWGGPVDSLTRAVVNRVNDLGGINGTKLKVVSEDEKFNAEDGVRAVTKLINSDNAQFIIGPTSGTFMATLNQAERSEVVIASPYAGMVEFDARANPYTFRTVGPDTFDGLTVAKNIWDQGFKTLSILYENVDSARSTSNWVEDFYTKLGGKVAAKVAFNGGQSSYLPEVRSAFEPKPDMVFLAGSVEPAVPILREWARLRLPGNWSFISELTYPVLIKEVGAQYLEGAFGQTPMAADSPAIAGMRELLTEEYGEQEGNEIAEQPTAGLTYDAIVSAILAMAAGGEATGVAIAENLHKVTDSGGKPVYTVDEGLELLAKGEKIDYQGASGPVDFTSTNTAAPDYGIFQVIDGQWQVTRRYTGTELYDLAEELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB70</accession>
    <name>A0A132PB70_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859726.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19544">
        <property type="protein sequence ID" value="KWX19544"/>
        <property type="gene ID" value="AFM11_35225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5776"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="10"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="268" mass="28617" checksum="A28A7631319BE614" modified="2016-06-08" version="1">MTVSADKQCEILAVALQKGGVGKTTTTINLAANLAAMGLRVLVIDMDQQAHSTKGLGIELDAEDASMYEVLHPDRAMRVPLAKVIVPTQFGIDVAPGHLALKELERTGLGSGGQLRLARQLDDIEGYDFVLLDCPPALGELTTAALAAADYVLAVLKAGPDEVDGLVELGNSILDVQETLNPDVEIRYVLLADFDGNPKASKDVRRQLRADWGEWSDGGAYLGEIPHTVRVVEAKGKRVPVNVHAPTSTAAVAYREVAERIAARRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBH6</accession>
    <name>A0A132PBH6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19685">
        <property type="protein sequence ID" value="KWX19685"/>
        <property type="gene ID" value="AFM11_34710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5289"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="130" mass="13788" checksum="62195DCBC58EE158" modified="2016-06-08" version="1" fragment="single">GLSEDQIKTIIATAKIESGFRPTVSGGVQAYGGPGTAADEVIGLFQEKASFGTVAERQDPNKAIARFIVRFTEAYKKYRITSDTVLAATLAQNPQLFKNHGGVGTHYYNTVKAAMSAAADLYSRAVGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBI5</accession>
    <name>A0A132PBI5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859392.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22240"/>
    <dbReference type="EnsemblBacteria" id="KWX19678">
        <property type="protein sequence ID" value="KWX19678"/>
        <property type="gene ID" value="AFM11_34670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5281"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022480">
        <property type="entry name" value="F420_MSMEG2906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03856">
        <property type="entry name" value="F420_MSMEG_2906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="269" mass="29775" checksum="559B79721469BB10" modified="2016-06-08" version="1">MTRPVRVAVQIQPGGAPDYRTWRDAVLAADDLGADVIFGYDHFHRPAMKGIVDGKPIMFDEQPDVANFEGWTALASWGEITSHAEIGLLVTGVGYRNPDLLADMARTVDHISGGRLILGLGAGWYEKDYTTYGYEFGTFSSRFDLFDESLIRIENRLAALIPPPVRKLPILIGGTGPKRSLPAVARHADIWHAFQDLDAFRKSSERVDELAATFGRNGADIERSTLWENAESADAFREAGVTLFQTELTSDNGYDLTSLKQVLTWRDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBJ5</accession>
    <name>A0A132PBJ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome BD ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_34485</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859424.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19688">
        <property type="protein sequence ID" value="KWX19688"/>
        <property type="gene ID" value="AFM11_34485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5242"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX19688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="468" mass="51020" checksum="2840DE0434F7E7BF" modified="2016-06-08" version="1">MTDAVLVLASNGPPGLLPARQQMAVSLGFHIILACFGVAFPAMIYVIHRRGIVRNDSVALGLARRWAKVSAVLFAIGAVSGTVLSFEMGLLWPGLMSRFGDVLGLPFAFEGLSFFIEAIFLGIYLYGWDRLPPRRHLAMLIPMAISGIVGTFCVVSVNAWMNHPAGFDIQDGRVTNIDPWAAMFNEGVWLQFLHMWVAAFMVVGLTVSGVYAAGLLRGRDDAHHRLGFRVPFVFASVAAVAQPFIGHVLGMRIHDTQPAKLAAFELAPKTEGPAPLRLGGLLIDGEVRWAFSIPRLGSIIARNSWDAPVPGLDTVPATDRPPANITHLAFQSMVMIGTLLAAAVVLFWVARWRGWDLLKARWFLWFAVVAGPLAIVAVECGWTATEVGRQPWTVWQVLRTSDAASMSSGLWWSYVGVLVFYLGMAVGAYVVLRSMARRWRSGEENLPSPYGPAAVVSKRQSDGRDSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBS9</accession>
    <name>A0A132PBS9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_35810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000051">
        <property type="protein sequence ID" value="KWX19442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859975.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19442">
        <property type="protein sequence ID" value="KWX19442"/>
        <property type="gene ID" value="AFM11_35810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6241"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="230" mass="24852" checksum="5906349EE99AF86E" modified="2016-06-08" version="1">MSSSQPDRVHDEDDDDIDPRRTRSRNRLLDAAATLLSTGGVEAVTVDAVTKASKVARTTLYRHFGSSSHLLAATFERLLPQVTPPAPASGTVRERLIELLTRQAALFADAPLHVTMLAWLSLGPTATTDHAGGEHAAGTLRARVVDQYRQPFDAILQSTDARAELDDFDLNLALCQLIGPLAFARMTGLHTMTPHDTTRIVDDFLTTHQRKTTPTAPTPPGDNAVAVTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBV4</accession>
    <name>A0A132PBV4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="10">PRA-PH</shortName>
            <ecNumber evidence="3 10">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">hisE</name>
        <name evidence="11" type="ORF">AFM11_33705</name>
        <name evidence="12" type="ORF">AWC31_08050</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PRA-PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="3 10"/>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858838.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08050"/>
    <dbReference type="EnsemblBacteria" id="KWX19815">
        <property type="protein sequence ID" value="KWX19815"/>
        <property type="gene ID" value="AFM11_33705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10119">
        <property type="protein sequence ID" value="ORX10119"/>
        <property type="gene ID" value="AWC31_08050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5077"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX19815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX10119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="93" mass="10208" checksum="6DA7FF0C4CA83DB8" modified="2016-06-08" version="1">MKQFMPVKTFDALFAELSDKAQTRPAGSGTVAALDAGVHGLGKKILEEAGEVWLAAEHESDEALAEEVSQLLYWTQVLMISRGLTLDDVYRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCE0</accession>
    <name>A0A132PCE0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858311.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32190"/>
    <dbReference type="EnsemblBacteria" id="KWX19993">
        <property type="protein sequence ID" value="KWX19993"/>
        <property type="gene ID" value="AFM11_32815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4892"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="170"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="29582" checksum="570E63AAE91A4151" modified="2016-06-08" version="1">MVDRRKRGLEVFRDVMTAPVPDDDSPVADGLLDFVFAEIWTRPGLSRRDRRFVTLACVAAADAQEPLEQHVYAALNSGDISITEMREAVLHFAVYAGWPKASRFNIVVDLQWQRILDERGESAAPPEPLLPLPTESDPEKRLQGGEKTFIEVNCIPFAPLRDNPFQGAGILNFVFGEMWQRPGLGMKERRLITVACVAFQDAEIPILSHVYAALKSGDVSFDEMDELALHFAAYYGWPKGSHLNQVVADQKQRVMAEGGPNTSDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCR2</accession>
    <name>A0A132PCR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858223.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19635"/>
    <dbReference type="EnsemblBacteria" id="KWX20120">
        <property type="protein sequence ID" value="KWX20120"/>
        <property type="gene ID" value="AFM11_32500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4828"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453144" evidence="2">
        <location>
            <begin position="31"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="479" mass="50700" checksum="4D7672A2C2AE64D2" modified="2016-06-08" version="1">MGRLCWWVSLACCAVLLAGCGSGTVVQGKATSMLFDPNRVGGLPVTEGHSGIRPDAPAPARSAENTDGGQIDNLALLAIDDIEDFWSQNYGGGSLFGEFTPVERLVSFNSDQEPGLEICGQNTLGLTNAFYCTNADVMAWDRGVAIPVAAQYFGQMGVVGVMAHEYGHAVQHQARLVDPSTPVLVSEQQADCFAGVYLRWVAAGNSPRFELSTGDGLNHVLAGLIYIRDPLMTQLNAVMTGNEHGSALDRVSAFQIGFSGNVDQCAAIDMTEIKKRRGDLPKFLDSEFFGQTQSGNTTITTDLLTDLMEVLGQIYAPATPPKLSTEPAECPDAKPSPPASYCPSTNTITVDLPGLKALGEAKNENDEQELLQGDNTAISVLTSRYALAVQHQKGLAIDTPVSAMRTGCLTGVAQARMAEPDQAIRLSAGDTDEAISGLLTNGLAASDVNGALLGAGFSRILAYRSGLQGDDAQCYQRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD06</accession>
    <name>A0A132PD06_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857444.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20231">
        <property type="protein sequence ID" value="KWX20231"/>
        <property type="gene ID" value="AFM11_31320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4170"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="79" mass="8909" checksum="BFDF4E28A0A400BE" modified="2016-06-08" version="1">MAMHTDDTISDTARPRREDAIGTPPERPTLIPAERYYSPAPGFTHLVLSGEERRIINMHRNLERYLQLSEDALATGMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDG5</accession>
    <name>A0A132PDG5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857162.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26590"/>
    <dbReference type="EnsemblBacteria" id="KWX20356">
        <property type="protein sequence ID" value="KWX20356"/>
        <property type="gene ID" value="AFM11_30870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4076"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="35"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="353" mass="38450" checksum="B860028ED5DBFFF3" modified="2016-06-08" version="1">MPGDVQQLPTLSDTDQAALQRWVRAQGIGSRVTDVAPLTGGTQNIVVRLHLDGRPMVLRRPPVHPRPTSDKTMMREIAVLRTLAGSGVPHPGFIAGCTDLDVLGVVFYLMEEVDGFNPGNEVAPAYHDAGMRHRVGLSYAGSLAQLGNVAWENSELAAIRPPGSFLARQVPQFLKLLESYRHDDYQPESLTDVGELARWLEDNRPPDSEPGIMHGDAHLNNVLLRREVPELAAFIDWEMCTVGDPLLDLGWMLVCWPHDPNPINAGAAIAALGDLAGRGELLDAYRDAGGRETSRLDWYVALACFKLGIVIEGTWSRYLAGQASREAGEQLHASAENLIALGTRVTKGDSPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDH9</accession>
    <name>A0A132PDH9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_31650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857622.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26265"/>
    <dbReference type="EnsemblBacteria" id="KWX20287">
        <property type="protein sequence ID" value="KWX20287"/>
        <property type="gene ID" value="AFM11_31650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4234"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="222" mass="24754" checksum="E4EFD496A53CD69C" modified="2016-06-08" version="1">MTVPDFAARPQLAEDVARLIRRRIFDGTYPAGNYIRLEQLAAELGISVTPVREALFGLRAEGLLTQQPRRGFVVLPVTRRDIDDVAGVQAHIGGQLAARAAGQISDGQLDELERIQRELEDAYTKNDHERAVRLNHAFHRGVNLAAESPKLAQLMSQITRYALESVYPTVEGWPEQSTHDHRRILEALRARDGDQAREAMSEHLCAASKPLTDHLARLGVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDJ7</accession>
    <name>A0A132PDJ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857310.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26860"/>
    <dbReference type="EnsemblBacteria" id="KWX20403">
        <property type="protein sequence ID" value="KWX20403"/>
        <property type="gene ID" value="AFM11_31150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4134"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="27133" checksum="63CA7F2C8526A133" modified="2016-06-08" version="1">MHEAHELPSAADIDIAAVAALLADAARCKVLLALDDGRALPASVLADEAGVSRPTASSHLHKLTDAGLLSVQTHGRHRYYRLAGPEVGALLEQLGRLAQARPVTSLREGTRAARLRSARTCYDHIAGRLGVQIMGCLIGREVLVGGDGHYHPERDMHDALSSPGHDVEYALTATGRDFLTDIGIELPSGRRPLVRYCVDWTEQRHHLSGRLGRAVLDPSLSAGWLRRAPRGRALTVTDAGRTAFSKTLGIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDL3</accession>
    <name>A0A132PDL3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Formate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_30690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26410"/>
    <dbReference type="EnsemblBacteria" id="KWX20419">
        <property type="protein sequence ID" value="KWX20419"/>
        <property type="gene ID" value="AFM11_30690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4040"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="708" mass="76570" checksum="B263514977B2A146" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDZ9</accession>
    <name>A0A132PDZ9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenosylhomocysteine nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_29575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.9" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856444.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24915"/>
    <dbReference type="EnsemblBacteria" id="KWX20555">
        <property type="protein sequence ID" value="KWX20555"/>
        <property type="gene ID" value="AFM11_29575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3806"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010049">
        <property type="entry name" value="MTA_SAH_Nsdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01704">
        <property type="entry name" value="MTA/SAH-Nsdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="6">
        <location>
            <begin position="2"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="26833" checksum="06D267B4715BC301" modified="2016-06-08" version="1">MPIGLISAIPQELAHFRSVMGDVRGEDIAHTRFETGTLDGCEIVLAETGMGKVNAAVVTTVLAHRFGCRTVVFSGVAGGLDPQLHVGDVVIADRLIQYDAGLVEDERLQVYQPGHVPFINPTDRLGYDVDSAVLEKVKQALRGLELPPLSRRAGGHGRAAQLVYGTVLSGDQYLHSETTRIRLHDEFGGRAIEMEGGAVAQVCEAFGIGWLVIRALSDLAGQDSQFEFNQFAGEVAASSAMVLRTLLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEH9</accession>
    <name>A0A132PEH9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20748">
        <property type="protein sequence ID" value="KWX20748"/>
        <property type="gene ID" value="AFM11_29250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3735"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="276" mass="28641" checksum="016E98AD78514424" modified="2016-06-08" version="1">MHPGLRRALESLIAGWNSIGAQTRFYVTTLSSIPDAVVHCRTELLRLIAQMGLGSGALAVVGGTVAIVGFLTMTTGALVAVQGYNQFASVGVEALTGFASAFFNVRLIVPGTTAVALSATIGAGATAQIGAMRINEEIDALEVLGVRTVAYLASTRVLAGVIVVIPLYCVAVMMAFLAARTGTTAIYGQGSGVYDHYFNTFLNPTDLIWSFFQAVAMTVVILLVHTYYGYTATGGPAGVGEAVGRAVRTSMVVAAVEIVFVSLAIYGQSGNFNLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEK2</accession>
    <name>A0A132PEK2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857345.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26905"/>
    <dbReference type="EnsemblBacteria" id="KWX20412">
        <property type="protein sequence ID" value="KWX20412"/>
        <property type="gene ID" value="AFM11_31195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4144"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="282" mass="30233" checksum="9A0EEA7532BF01C4" modified="2016-06-08" version="1">MSAASVLIAADHADGAAPDAPRYTLLLSTDAELIEAAQRLRHDVFTSEPGFALSGAADGRDADRFDEHCDHLLVREDGTGELVGCYRMLPPPGAIAAGGLYTATEFDVRGLDALRPSLVEMGRAVVRADHRNGGVVLLMWAGILAYLDRSGYDYVTGCVSVPVAGNADGPPGTQIRGVRDFVRRRHAAPEEYTVYPYRPVVLDGKGLDDVDPPSRTTVPPLMRGYLRLGAQVCGEPAHDPDFGVGDFPALLDKRKADVRYLKRLRSVSAAADMADGMTGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEQ0</accession>
    <name>A0A132PEQ0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFM11_28695</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856232.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32925"/>
    <dbReference type="EnsemblBacteria" id="KWX20810">
        <property type="protein sequence ID" value="KWX20810"/>
        <property type="gene ID" value="AFM11_28695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3620"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051409">
        <property type="term" value="P:response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023950">
        <property type="entry name" value="Hmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="PTHR43396:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="18">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="167"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KWX20810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="411" mass="44158" checksum="B2DF87DE7C2B2AC9" modified="2016-06-08" version="1">MTVTSPEPSAVRDELEPQHAEIVSATLPLIGAHIDEITSAFYRRLFENHPELLRNLFNRGNQAQGAQQRALAASIATFATHLVNPDLPHPAALLSRIGHKHASLGITADQYPIVHDNLFAAIVEVLGAETVTAEVAAAWDRVYWIMADTLIGLERDLYAAAGAEPGDVYRRLRVVSRVDDPSGAVLVTVRASEPVHFVPGQYVSVGVTLPDGARQLRQYSLVSVAGSTDLTFAVKPVDATATQPAGEVSSWIRANVCVGDLLDVTVPFGDLHTERADGRPLVLISAGIGITPMIGILEHLAAKRPDTHVRVVHADRSDNAHPMRERQHELIDALPNASLDVWYEDGLTGGAPGVHAGLLNLDGIELPADPDIYLCGGAGFVQAVRGQLTGRGVPAERVHCELFSPNDWLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEY0</accession>
    <name>A0A132PEY0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855716.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10345"/>
    <dbReference type="EnsemblBacteria" id="KWX20899">
        <property type="protein sequence ID" value="KWX20899"/>
        <property type="gene ID" value="AFM11_27815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3437"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="221" mass="24791" checksum="D85D28348C9DD840" modified="2016-06-08" version="1">MDVYEAVTTRRAVRGFTDRPVSKDVLAQVLTAARWSPSSSNTQPWNIYVVTGAPLAELKKRATERVATGADWDEREYTMYPHDMPAPYRDRRAAFGKERYSALGVARDDWEARQRAAIANWDCFGAPAALFCYIDRNLGPAQWADTGMYLQTVMLLLRAEGLHSCPQMAWSQVRQTVADVLSPPDNLMLFCGMSIGYEDPTVPYIRTGRAPLDETVTFVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFC8</accession>
    <name>A0A132PFC8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855288.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06940"/>
    <dbReference type="EnsemblBacteria" id="KWX21048">
        <property type="protein sequence ID" value="KWX21048"/>
        <property type="gene ID" value="AFM11_27095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3293"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="138" mass="15474" checksum="74A25F21400317BC" modified="2016-06-08" version="1">MMRIASTHLWVHDQEAALKFWTEKVGMEVREDVTLPDVDTPFRWLTVGPPGQDDVSIVLMAVPGQPVMDEDTRKQVLDLTAKGFAGTVFLTTEDCQKSYEELTARGVEFTEPPNQMPYGIDSGFRDPSGNSVRLTQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFK5</accession>
    <name>A0A132PFK5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855561.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06960"/>
    <dbReference type="EnsemblBacteria" id="KWX21139">
        <property type="protein sequence ID" value="KWX21139"/>
        <property type="gene ID" value="AFM11_27110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3297"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="603" mass="64582" checksum="A6A1CEF0612A7366" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFV6</accession>
    <name>A0A132PFV6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_26520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854967.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22815"/>
    <dbReference type="EnsemblBacteria" id="KWX21211">
        <property type="protein sequence ID" value="KWX21211"/>
        <property type="gene ID" value="AFM11_26520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3174"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="213" mass="23195" checksum="9C847EA0B2AF1A9A" modified="2016-06-08" version="1">MTTASQARAPRGRRSNRPSGDDREAAILATAERLLDDKKFSDISVDDLAKGAGISRPTFYFYFPSKEAVLLSLLDPLIKRADTGFDNALEGMPADPHRAIRRGIEIFFSSFGSHPATARAGTEALNSSPEFRTFWSGLMQKWIALTAALITAERERGAAPDTIPALDLATSLNLMNERTMMAALSAEQPAVEHDKVVDTLSHIWLNSIYGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG86</accession>
    <name>A0A132PG86_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzene 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854535.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36085"/>
    <dbReference type="EnsemblBacteria" id="KWX21341">
        <property type="protein sequence ID" value="KWX21341"/>
        <property type="gene ID" value="AFM11_25810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3026"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00667">
        <property type="entry name" value="ring_hydroxylating_dioxygenases_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017641">
        <property type="entry name" value="Benzo_1-2-diOase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000391">
        <property type="entry name" value="Rng_hydr_dOase-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41534">
        <property type="entry name" value="PTHR41534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00866">
        <property type="entry name" value="Ring_hydroxyl_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03232">
        <property type="entry name" value="benzo_1_2_benB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="172" mass="20596" checksum="115839ED5EE2B850" modified="2016-06-08" version="1">MNTAQQTGAKLITQNAIEQFLYREARYLDDREFEKWLECYADDVVYWMPSWSDDDRLVEDPQRDISLIYYANKGGLEDRVFRIRTERSSATSLPEPRTSHNISNVEVIERRGDLVDVRFNWHTMYFRYKTVDPYYGTSCYTIDFSGEQPLIRRKTVVLKNDYIHHVVDVYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGT7</accession>
    <name>A0A132PGT7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_24935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854332.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27190"/>
    <dbReference type="EnsemblBacteria" id="KWX21555">
        <property type="protein sequence ID" value="KWX21555"/>
        <property type="gene ID" value="AFM11_24935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2349"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453262" evidence="2">
        <location>
            <begin position="23"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="325"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="390" mass="40511" checksum="3A1AE10668C49AC9" modified="2016-06-08" version="1">MTVIALVLLAFIAGPVPTAAAAAPNWSGLDARHFDGPIPAPGTLIESVPLDPALSLPGAGAAYRILYSTIDQHDSPAVSTAAVFLPHGEAPDGGWPVIAWAHGTVGLGDDCAPSAQPRSERDSEYLTHWLDQGYAIVGSDYAGLGTPGLMSYLNSVATAHSVVDSVIAMHHMDLPLSPKWALVGQSQGGGAAVNSARWATEFSRGSGLDYRGVVATGTPFNVESIVKQAGPDMALPPNLGPAANSYTGYILAGFREARPDIDVNSVLTPAGVVAVDKAETLCKSELDAALAGMTPTGFFRAPLSTLPGISDALDAYLGTPTSGYDRPIFLGVGLLDHDVPPNMSMQLNDQLRANGQDVTLKIYPDEDHSGTVLASLPDSTPFLRAMFDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH43</accession>
    <name>A0A132PH43_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_24365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853710.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23750"/>
    <dbReference type="EnsemblBacteria" id="KWX21655">
        <property type="protein sequence ID" value="KWX21655"/>
        <property type="gene ID" value="AFM11_24365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2233"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="76"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="282"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1294" mass="144137" checksum="4E968B49F39631A3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHD5</accession>
    <name>A0A132PHD5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Formate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35860"/>
    <dbReference type="EnsemblBacteria" id="KWX21412">
        <property type="protein sequence ID" value="KWX21412"/>
        <property type="gene ID" value="AFM11_26040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3072"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="3">
        <location>
            <begin position="4"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Molybdopterin" evidence="3">
        <location>
            <begin position="400"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="4">
        <location>
            <begin position="693"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="841"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="862" mass="96624" checksum="50694B7C28EC14D8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHX6</accession>
    <name>A0A132PHX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852770.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08615"/>
    <dbReference type="EnsemblBacteria" id="KWX21950">
        <property type="protein sequence ID" value="KWX21950"/>
        <property type="gene ID" value="AFM11_22590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1868"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="239" mass="24851" checksum="AD4D2B0D6FE6975E" modified="2016-06-08" version="1">MIVTGGAGVIGQAICRRLLQSDYVPVAADLKPAVDVLDLEQSGLQGTVPVAMDVADRESIESAVTSVVDDGETISGLVNCAGILRDSFLGELDEAKLELMFQVNIAGMARVTDVVAPLLTQGSAIVNIGSLTGHFGRFRGASVYGATKAGIAAYTRYLAEELAPRGIRVNNIAPGVIRAPMSPSMARVSGGEEVSAGYAMLGRIGEPEEVAEAVEFMLSPRASFITAQTLLVDGGVVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI25</accession>
    <name>A0A132PI25_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pup--protein ligase</fullName>
            <ecNumber evidence="3">6.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proteasome accessory factor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Pup-conjugating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pafA</name>
        <name evidence="5" type="ORF">AFM11_22900</name>
        <name evidence="6" type="ORF">AWC31_08300</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N(6)-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine.</text>
            <dbReference type="EC" id="6.3.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein pupylation.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.19" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852883.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08300"/>
    <dbReference type="EnsemblBacteria" id="KWX22009">
        <property type="protein sequence ID" value="KWX22009"/>
        <property type="gene ID" value="AFM11_22900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10161">
        <property type="protein sequence ID" value="ORX10161"/>
        <property type="gene ID" value="AWC31_08300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1933"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="UniPathway" id="UPA00998"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02111">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022279">
        <property type="entry name" value="Pup_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03686">
        <property type="entry name" value="pupylate_PafA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX10161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="447" mass="50699" checksum="B23DB4373FDCBB65" modified="2016-06-08" version="1">MGIETEFGVTCTFHGHRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATAECDNLIQLVTHDRAGERVLEDLLIDAEQRLADEGIGGDIYLFKNNTDSAGNSYGCHENYLIVRAGEFSRISDVLLPFLVTRQLICGAGKVLQTPKAATFCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAEKYRRLHVIVGDSNMCEATTMLKVGTASLVLEMIEAGVPFRDFSLDNPIRAIREVSHDLTGRRPVRLAGGRQASALDIQREYFTRAVEYLQTREPNTQIEQVVDLWGRQLDAVESQDFAKVDTEIDWVIKRKLFQRYQDRYNMELSDPKISQLDLAYHDIKRGRGVFDLLQRKGLAARITTDEDIDAAVNTPPQTTRAKLRGEFISAAQEAGRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDERVKRLIASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI36</accession>
    <name>A0A132PI36_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">L-ectoine synthase</fullName>
            <ecNumber evidence="4 7">4.2.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">N-acetyldiaminobutyrate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ectC</name>
        <name evidence="8" type="ORF">AFM11_22955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine</text>
            <dbReference type="Rhea" id="RHEA:17281"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58515"/>
            <dbReference type="ChEBI" id="CHEBI:58929"/>
            <dbReference type="EC" id="4.2.1.108"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the ectoine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.108" evidence="4 7"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852900.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08250"/>
    <dbReference type="EnsemblBacteria" id="KWX22019">
        <property type="protein sequence ID" value="KWX22019"/>
        <property type="gene ID" value="AFM11_22955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1944"/>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033990">
        <property type="term" value="F:ectoine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06978">
        <property type="entry name" value="cupin_EctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01255">
        <property type="entry name" value="Ectoine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010462">
        <property type="entry name" value="Ectoine_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39289">
        <property type="entry name" value="PTHR39289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06339">
        <property type="entry name" value="Ectoine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="130" mass="14375" checksum="5836A33EB209C8AF" modified="2016-06-08" version="1">MIVRTTAEITGTDRDVSDGSWRSKRIILAGDGVGFSFHETTIEAGSVNEFRYEHHVEAVWVVEGTGTLTNLETGERHPLGPGTMYLLNGHERHRVTCDEQLRMLCVFNPPVTGQEVHDETGAYPPPQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI89</accession>
    <name>A0A132PI89_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852315.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04195"/>
    <dbReference type="EnsemblBacteria" id="KWX22069">
        <property type="protein sequence ID" value="KWX22069"/>
        <property type="gene ID" value="AFM11_21380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1623"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="280" mass="29016" checksum="21762AAA44B88647" modified="2016-06-08" version="1">MTTTFTPAFDINRSGTTPALGRELRLRRLFAADGRTVTVALDQAVPRGVAPRLANIGPTFDSIADGEPDAVTITKGLAGPLFGGRATPMPWILKASMFSVEFHPTYDATIGTVHDAIRLGADAVAVGISAGSSNQVAMFEMLTKVVEEAHTWGLPVVCHAYPSGELWGDRKGSTESVLYASRAAAELGTDIVKTWYTGSTAEFAKVVEGTPAIVVAAGGAPAPSPLDVLKQAASVVEAGGHGMTAGRNIWQAADPAKMVNALKAVIHGGDAPEVAAKLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIB5</accession>
    <name>A0A132PIB5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852355.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04320"/>
    <dbReference type="EnsemblBacteria" id="KWX22090">
        <property type="protein sequence ID" value="KWX22090"/>
        <property type="gene ID" value="AFM11_21505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1649"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="243" mass="25431" checksum="9F3829AEE5875C84" modified="2016-06-08" version="1">MTETDRVALVTGAARGQGAAIVSRLVADGFQVAATDVLVDDLTTATARFGDKVTAIGLDVASAEQWQRAVEATVQRFGALSTLVNNAGVLHRASIPDETPQGFEGTWRINCLGPFLGIRAALEHLRRAENAAVVNTCSTGAIRPFPDHVAYGSSKWALRGLTQVAAAELGPDGIRVNAVFPGPVETPMLDETTQTRLAERSVAGRLGKPAEIADAVAFLVSEHASFITGSELVVDGGQCLQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIK6</accession>
    <name>A0A132PIK6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_21800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852440.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04605"/>
    <dbReference type="EnsemblBacteria" id="KWX22133">
        <property type="protein sequence ID" value="KWX22133"/>
        <property type="gene ID" value="AFM11_21800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1708"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="213"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="414" mass="43443" checksum="02996F129FEFE589" modified="2016-06-08" version="1">MGVPAVLRNRDFDLYWTGVVFSQIGTRGTVAANLYHVYALTGSVMQTGLVGAAQAIALLVLSPLGGVYADRWDRRRLLQASQATAMLVAGALAVLTLTRHVAAWQVLVSVVLTTAAATFDQPARQALIPALVPRSQLPQAFALLNPSREIAVLLGPALAGIFIGIAGPGLMYAVDAGTYAVLVLLLQALRTGKLDGAGKRISVWRQIGEGARFVARRKIIWMLMSLDLSATLFGAYRVVLPALCATVFHVGPQGYGLLSAAPSAGALLATYTVFRVVDRAQRLGRVLLIATVLYGLANVVLAQAHVFLIALLAGCLVGGFDAMATTIRHAAVQLETPDELRGRVSAFYQMSSRGGPALGDTLIGAAAGVLGPVVALTLGGLVAALYPVVFLVRPNPVRFYEGVAAEDEGAVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIM0</accession>
    <name>A0A132PIM0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21695</name>
        <name evidence="2" type="ORF">AWC31_04500</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852403.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04500"/>
    <dbReference type="EnsemblBacteria" id="KWX22114">
        <property type="protein sequence ID" value="KWX22114"/>
        <property type="gene ID" value="AFM11_21695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10556">
        <property type="protein sequence ID" value="ORX10556"/>
        <property type="gene ID" value="AWC31_04500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1687"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="235" mass="25247" checksum="4292288601B81554" modified="2016-06-08" version="1">MTTYLQQAQTGVWDVRASFLPQIYFNGVNLAGGIALLLPPQPVDDEVTDRVLDRVDGLVITGGPDVDPARYGQAPHPSTNEPAHDRDEWEFALLAGALRRGIPVLGVCRGAQVLNTALGGTLHQHLPDVIGHTHHQKGDAIFGTSAVRTVPGTKLAELIGETSDAQCYHHQAIDRLGDGLVVSARDTDGVIEAVELPGDGFVLGVQWHPEERLDDLRLFTAIVEAAKAHATERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIM9</accession>
    <name>A0A132PIM9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_23760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853357.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29885"/>
    <dbReference type="EnsemblBacteria" id="KWX21862">
        <property type="protein sequence ID" value="KWX21862"/>
        <property type="gene ID" value="AFM11_23760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2109"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="401" mass="44336" checksum="525B72B272CC0E5D" modified="2016-06-08" version="1">MTGQATLPPLHMRRNTFDPTPELGEIRETAGVRTVVNAFGMEIYLVTRHDDVKAVLSDHERFSNTRPPGFVMPGAPQLSAEDQASARAGNLLGLDPPEHQRLRRMLTPEFTIRRMKRLEPRIVEIVDAQLDTMQSAGPPADLVADFALPIPSLVICELLGVPYEDREDFQQRSARQLDLSAPIPERLELQRQGREYMRGLVARARREPGDDILGMLIREHGDELSDDELVGVAGLLLLAGHETTSNMLGLGVLALLRHPDQLAMVRDDPDAVGPAIEELLRWLSIVQTAIPRITTTDVELAGVPIPAGQLVFASLPAGNRDPGFVEAPDVLDIRRGAPGHLAFGHGVHHCLGAPLARMEMRTAFPALLRRFPGLRLAEPFEDVQWRSFHFIYGLKSLAVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIS1</accession>
    <name>A0A132PIS1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase TesA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_20635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852024.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06050"/>
    <dbReference type="EnsemblBacteria" id="KWX22249">
        <property type="protein sequence ID" value="KWX22249"/>
        <property type="gene ID" value="AFM11_20635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1464"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Thioesterase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="249" mass="26908" checksum="5DEF066C124745DB" modified="2016-06-08" version="1">MTGSDTQLTFKPWIKRYPGDDPAAKPTLVFPHAGGAAVAYRSIGNALAAAGSDAYVMQYPKRGDRMAHPALGTVDALARDLFEAGDWSQLGPLRLFGHCMGAVVAFEFARVAERNGVAVDALWVSASEAPSAVAASPALPMAESEIIAEMVDLGGTDPQLLADEDFVELLLMAVRADYEAFNRYACDTDVTIAADIYAIGGERDHRISEDMLRRWEIHTGGAFTLSMFDGGHFFINEYTEDVAELVNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIU8</accession>
    <name>A0A132PIU8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF222 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22231">
        <property type="protein sequence ID" value="KWX22231"/>
        <property type="gene ID" value="AFM11_22195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1788"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF222" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="245" mass="26155" checksum="D40BDFC1B3B81F2E" modified="2016-06-08" version="1" fragment="single">LNAEARAVVEPLLAKYAAPGMCNPDDPAPCVTGVPSEEAVEANTRTAARRNHDALVAIGRNALMSGELGSHNGLPVSLIVTTTLAELEAGAGIAVTAGGSKLPIPDVIRLAAHAWHYLAVFDDATLVPLYFGRTKRIATPAQRLVLFARDRGCTRPGCTAGGYRCQAHRAQHDWTVGGQTNIDELALSCGPDNRLVAKGKWTTTMRNGRCQWTPPPLLDTGQARTNGYHHPQTYLTDNDEDDEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ53</accession>
    <name>A0A132PJ53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852116.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06315"/>
    <dbReference type="EnsemblBacteria" id="KWX22294">
        <property type="protein sequence ID" value="KWX22294"/>
        <property type="gene ID" value="AFM11_20895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1520"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010219">
        <property type="entry name" value="UCP010219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="229" mass="24565" checksum="3B6145283C90AF49" modified="2016-06-08" version="1">MPTPDLDLYPDEGEPVTGEPTEEQTPTLLERMGGVSGLVHASVPTFAYVIANAVAGLSAAVVVAVGTSIGLIALRLVRKEPLQPAISGLLGVVIAGLIAYYTGSADNYFLPGIWISLAMAAAFTLSVLVRRPLIGVIWNLMRTSGPDPSWRADKVTLHAFDVATLVFVAVFAARFIVQQWLYDGGFTGWLAVARIAMGYPLLGVALLVTYWAVRRANRRLGDEPDRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJH2</accession>
    <name>A0A132PJH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_20245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11470"/>
    <dbReference type="EnsemblBacteria" id="KWX22485">
        <property type="protein sequence ID" value="KWX22485"/>
        <property type="gene ID" value="AFM11_20245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1384"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="8">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="95"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="260"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="362" mass="38120" checksum="0F2A6A62F3A82534" modified="2016-06-08" version="1">MMVTYAAPGRINLIGEHTDYNLGWALPIALPQRVVVQYRPDDSDSITVRSDRESGQVDIPLGTAPGDITGWAAYIAGVMWSLRTAGHPVTGGAMTITSDVEMGSGLASSAAVECAVLAALTNGQSIDRVEQARIAQRAENTYVGAPTGLMDQLASLFGQPQHAMLIDFRDLTVKPVPFDPDSAGISLLVMNSRAAHRHAGGEYASRRASCERVAAALQVDSLRELQYRGLAALDGLADPEDTRRARHILTENQRVFDFVAALEVSDYAKAGEILTASHASMRDDFEITTPHIDLIADTAVRAGALGARMTGGGFGGCVIALVPTDLADTVGGTVRDVVTGAGYPEPTIAPARAAIGAEQVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJP2</accession>
    <name>A0A132PJP2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851529.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_14905"/>
    <dbReference type="EnsemblBacteria" id="KWX22569">
        <property type="protein sequence ID" value="KWX22569"/>
        <property type="gene ID" value="AFM11_18815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1098"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="138" mass="15697" checksum="779B099C35141F33" modified="2016-06-08" version="1">MTRRNRARLDDVHEIAASMPYVKRIEGPKGNPIYQVGGKSFVFFRTPQPDAVDPDTGERYPDVIMIWVESESDKLALVQDPRSPFFTTDRFDDHPSVLLRASRLGEISRGELAELIQDAWLSRASSRRAEKWLAEHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJR2</accession>
    <name>A0A132PJR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18950</name>
        <name evidence="2" type="ORF">AWC31_15040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851573.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22589">
        <property type="protein sequence ID" value="KWX22589"/>
        <property type="gene ID" value="AFM11_18950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17751">
        <property type="protein sequence ID" value="ORX17751"/>
        <property type="gene ID" value="AWC31_15040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1124"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX17751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="136" mass="14406" checksum="493CFCB846DC9A1B" modified="2016-06-08" version="1">MLSPTAARKTLAVIRILNGTAGLLAPEKVLARLGVDTTEDRSGTYPFRMFGIRTVLIGLDLLLLTGDELRRAEKLAVLIHATDTVSAAVTAARGDLPRKQGRVAVVISAINTALAVTAWKGGQDAITAHEVVHQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJR8</accession>
    <name>A0A132PJR8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851494.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22405"/>
    <dbReference type="EnsemblBacteria" id="KWX22553">
        <property type="protein sequence ID" value="KWX22553"/>
        <property type="gene ID" value="AFM11_18690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1075"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="655" mass="70263" checksum="81D5876E2E926F99" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJR9</accession>
    <name>A0A132PJR9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851571.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15035"/>
    <dbReference type="EnsemblBacteria" id="KWX22588">
        <property type="protein sequence ID" value="KWX22588"/>
        <property type="gene ID" value="AFM11_18945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1123"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09818">
        <property type="entry name" value="PIOX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034815">
        <property type="entry name" value="A_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="597" mass="66840" checksum="0B2AC93773C094AC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJY6</accession>
    <name>A0A132PJY6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851716.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15470"/>
    <dbReference type="EnsemblBacteria" id="KWX22660">
        <property type="protein sequence ID" value="KWX22660"/>
        <property type="gene ID" value="AFM11_19385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1210"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="254" mass="26247" checksum="DC494509893AFE60" modified="2016-06-08" version="1">MRAQEFAARLRDRQRLLGYWSVIDSPVSTEWLAHVGWDYIALDLQHGLIGYSGMVAGLTAIDASSSAVGLVRVEANDATAIGRALDAGAAGVIVPMVDDAEAAARAVAAATYPPAGIRSYGPMRSQLRIGPVPAEANRDTVVLAMIETPGGLANVEQICRVPGLDGIYVGPSDLRLAIGGATSQDPAVADEFEAAVKRIRVAAENAGIAAGIHNPDGASAAKRLAEGYTFATVASDLVHLKQASAAHLKAAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK30</accession>
    <name>A0A132PK30_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851819.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22691">
        <property type="protein sequence ID" value="KWX22691"/>
        <property type="gene ID" value="AFM11_19570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1247"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="172" mass="17881" checksum="CC330074A65552FE" modified="2016-06-08" version="1">MTRGRVLVALLAVLLVASGCGLRGSEPQRGAVLVFAVGDCVSVPAGTPQAPEVVRAAEVDCSADPSYTVGAIADGSGTCPSSEYQHLPAEYADPSTARLCLVPNLVADHCYELGLPAGVVELADCSDRGQGVLVQVTQRLDVRDQAACPTAAGQFAWPYPSPARTYCTRTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKM2</accession>
    <name>A0A132PKM2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_17765</name>
        <name evidence="10" type="ORF">AWC31_11885</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851148.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11885"/>
    <dbReference type="EnsemblBacteria" id="KWX22794">
        <property type="protein sequence ID" value="KWX22794"/>
        <property type="gene ID" value="AFM11_17765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18695">
        <property type="protein sequence ID" value="ORX18695"/>
        <property type="gene ID" value="AWC31_11885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.908"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040767">
        <property type="entry name" value="DtxR_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18357">
        <property type="entry name" value="DtxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX18695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="231" mass="25357" checksum="0752F2BBBBCA3FE8" modified="2016-06-08" version="1">MNDLVDTTEMYLRTIYDLEEEGVVPLRARIAERLDQSGPTVSQTVSRMERDGLLHVAGDRHLELTDKGRALAVAVMRKHRLAERLLVDVIGLPWEDVHAEACRWEHVMSEDVERRLVQVLNNPTTSPFGNPIPGLSELGVGGAGFGSDDVSLVRLTELPVGLPVAVVVRQLTEHVQGDTELIGRLKDAGVVPNARVTVEANDHGGVMILIPGHEQVELPHHMAHAVKVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL57</accession>
    <name>A0A132PL57_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850864.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23081">
        <property type="protein sequence ID" value="KWX23081"/>
        <property type="gene ID" value="AFM11_17110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.775"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="63" mass="7232" checksum="8C6EC73280027C15" modified="2016-06-08" version="1">MITLFPSRDRRRRRTPNLERQVIWFTVGLYLLICAGLLALHYAHPQHEVGSSSVSPAHQSYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLG0</accession>
    <name>A0A132PLG0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850155.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15855"/>
    <dbReference type="EnsemblBacteria" id="KWX23180">
        <property type="protein sequence ID" value="KWX23180"/>
        <property type="gene ID" value="AFM11_15235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7160"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06355">
        <property type="entry name" value="PBP1_FmdD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017777">
        <property type="entry name" value="ABC_urea-bd_UrtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03407">
        <property type="entry name" value="urea_ABC_UrtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453380" evidence="1">
        <location>
            <begin position="21"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="417" mass="44512" checksum="9E98830A2E92587A" modified="2016-06-08" version="1">MSRRISVLPACVLALTTALALTSCGSRVGDETATPAANSCVDTSGDTVKIGAINSLSGPTAINETVIRDAIKLAVDEINASGGVSGKQLQLVAEDGASEPTVFAEKATKLINSDCVAAVFGGYTSASRKAMLPVFEDNNALLFYGQQYEGLEDSRNIFYSGATTNQQIIPSLDYLKEQGVKSLYLVGSDYVFPRTSNAIVRKYAEANGIEIKGEDYTPLGSTDFSTIVNKIRTADADAVFNVVVGDSLVAFFREFTNAGLTAKDMPVMSMCVGEEEVKAIGVQNVAGHLAAWNYYQTLDTPANQKFVSAFKTAYGADRVTSDPMESAYTGVYLWKAMVEKAGAFDVPAVQSAADGTTFDGPEGAVTVDGDTHHITKTARIGEIRPDGLIYQVWDSKTPIDPDPYLKTYPWATDIAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLG7</accession>
    <name>A0A132PLG7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23195">
        <property type="protein sequence ID" value="KWX23195"/>
        <property type="gene ID" value="AFM11_15310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7176"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="709"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1144" mass="124337" checksum="283BAFAF7A1FB600" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLI1</accession>
    <name>A0A132PLI1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_15335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850199.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16415"/>
    <dbReference type="EnsemblBacteria" id="KWX23199">
        <property type="protein sequence ID" value="KWX23199"/>
        <property type="gene ID" value="AFM11_15335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7182"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="6"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="484" mass="51222" checksum="841914FF96C62581" modified="2016-06-08" version="1">MTSSIGTRNIVDPATGTVIDTVPEHGAADVDAAVARAQAAFDDGAWPALTRSERARLLLRIADAIEEHSEELYRLETRNNGRPITETRAQLSRVPEWFRYNAGLLAAQRYGVLPGDGPYLTYQQRLPLGVCGIITPFNHPMLILARSLSAALANGNTVVVKPSELTPLTTLALARIMADAGLPDGVVTVVTGGRDAGVRLTEHPGIAKITLTGGTEAGRSAAVATASRFARVTAELGGKTPVIVFGDVDPVVAAEGAAFAAFVAAGQSCVAGSRFLVHCAIYDDFVTALSKRAAEIRIGDPADTETQMGPLISARQRDKVRGLIDIGVSEGARLATGGEVPELSGALRDGFFLQPTVLADATMDMTVATEEIFGPVAVVIPFDDEAEAVAMANDNRYGLGAGVWTTDLSRAHRVAARIVAGMVWINDHHRLEPSLPWGGVKESGTGKDAGTESFDDFSWVKTVVVRTAAESVDWYGRQDNGRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLJ0</accession>
    <name>A0A132PLJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850218.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23210">
        <property type="protein sequence ID" value="KWX23210"/>
        <property type="gene ID" value="AFM11_15400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7195"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="405" mass="44220" checksum="2F3D2908FB67BB94" modified="2016-06-08" version="1">MKVLEGVRVIDVSIAMAGPFAAQKLADLGADVIKVEPVTGEWQRHVSAGGARGNTVNASFLSLNRNKRSLSLNLKSPAGRRILTGLVETADVFLQNYRPGVADRLGVDYETLSAINPKLIYVSMSGYGQTGPYANRPGQDVLLQAMSGGLASARRGDEPPRPGPFFLADAFTAYSAFEGAMAALFHRQRTGEGQLVEVNMLDAIIAAQMQELSVATVGGVAQTPSDEIHAHSYIRAPYGVFATSDDFIALSFAEMDVLAKVFDDPRFEAFDSERDGFTHRDAISALVAENLKRDTTEHWLEVLGAAGVWVGPVYDYRQVVDDPQVRHNASFVEYDHPTEGHVKTPGFAFRLAKQPQEIYRPAPLNGQHTHEVLTELGYSDDDIDEFERAGVIYRDAVLATPELTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLJ4</accession>
    <name>A0A132PLJ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15450</name>
        <name evidence="4" type="ORF">AWC31_16325</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850233.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16325"/>
    <dbReference type="EnsemblBacteria" id="KWX23218">
        <property type="protein sequence ID" value="KWX23218"/>
        <property type="gene ID" value="AFM11_15450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17972">
        <property type="protein sequence ID" value="ORX17972"/>
        <property type="gene ID" value="AWC31_16325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7205"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453401" evidence="1">
        <location>
            <begin position="27"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="81"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX17972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="516" mass="56067" checksum="8D7FAFF3D71F36BC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLQ5</accession>
    <name>A0A132PLQ5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22942">
        <property type="protein sequence ID" value="KWX22942"/>
        <property type="gene ID" value="AFM11_18525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1039"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010753">
        <property type="entry name" value="DUF1330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07045">
        <property type="entry name" value="DUF1330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1330" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="78" mass="9360" checksum="38C064C5DB5976E7" modified="2016-06-08" version="1">MAQYAERVREIVVAFGGTYRLRHREVRVLEGSWDREYLTLIEFPSMSRLMEFYESEEYRPWLELRKRSGEGDLIAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLZ8</accession>
    <name>A0A132PLZ8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_15425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850552.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16350"/>
    <dbReference type="EnsemblBacteria" id="KWX23371">
        <property type="protein sequence ID" value="KWX23371"/>
        <property type="gene ID" value="AFM11_15425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7200"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="24799" checksum="D12073FB7210228B" modified="2016-06-08" version="1">MSIAGYVIIAAAIVLASCMQASIGFGMGMLAAPIVAIVDPGLIPGTLIMLATMVTLMVVVREREDIDLAGTGWALAGRVPGTIAGALLLVVLPERTLAYALAAVVLGGVALTSFGWIPAPHRRNLVLAGATSGLLGTATSIGGPPMALVWQNNTGARLRGTMSGFFLVGSVLSLVVLALTGSIDRHTVVVFAMLIPACVAGYGLSRWVNRHLDRQRQRWAAIVISTLGAVVLIVRQLIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMF1</accession>
    <name>A0A132PMF1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850562.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16040"/>
    <dbReference type="EnsemblBacteria" id="KWX23377">
        <property type="protein sequence ID" value="KWX23377"/>
        <property type="gene ID" value="AFM11_15725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7268"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="216" mass="21744" checksum="450B9CD1FAD0883F" modified="2016-06-08" version="1">MALVAMLTPGIAHAEPPVVLGGGSGIIVNGESFCTLTTIGHDNAGRLIGFTSAHCGGPGATVAAESAQNAGVLGTMVAGNDALDYAVIQFDPAKVTPTKNVSGFQIDGLGPDPVFGEVACKLGRTTGYSCGVTWGPGKDPGTIVNQVCGQPGDSGAPVTVNNRLVGMIHGAFTEDLPTCVVKFVPLHTPAVTMSFNTQLADITAKNRPGTGFVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PML7</accession>
    <name>A0A132PML7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850040.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17755"/>
    <dbReference type="EnsemblBacteria" id="KWX23578">
        <property type="protein sequence ID" value="KWX23578"/>
        <property type="gene ID" value="AFM11_15085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7128"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="317" mass="33695" checksum="2ED6B263F21A5558" modified="2016-06-08" version="1">MVSLRALESLVAVADHGSITRAAEALHSSQPAVSQQLAALERETRTQLFHREGRGVRLTPAGRAALSDARRALDAAAAAVRSARVVGEGASGSLRLACAQSLTVAFLAPVIQRWLHSDSAVMFTLRESTSMDVLLQVLDDDEVDVTFVAAPTSVPDRFTVTPVAEEEVVLTTTLDHRLAQQPAVRLDQLDGVPIVHFAPENGLVSWLDYSLAEAGVRPDPVMRTAVTASAPQLAATGIGVAITPISAVGDGFPGAVRSFSPRWFRQLVAITPAAPDPLAARFIGELRARGVRVPTEIRQQLATDLTTEDDLTHPDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMR0</accession>
    <name>A0A132PMR0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_16115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850471.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16690"/>
    <dbReference type="EnsemblBacteria" id="KWX23332">
        <property type="protein sequence ID" value="KWX23332"/>
        <property type="gene ID" value="AFM11_16115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7348"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="315" mass="32203" checksum="135350C3357E3D58" modified="2016-06-08" version="1">MQVLVVGIIALALAGSTLRAFVEGTPDVATAATVFCGVFVQALPFLALGVVISGLIAVFVTPDRLARWLPERTGAAILAAGLGGAALPGCECGSVPVARRLFGEGGVGAAALTFMLAAPAINPVVLVATAVAFPGHPQLVAARCAASLLTALIMGAAWARFGRPEWITRQLPKLHGGDGPRWAVFTEAARHDFLSACSYLVVGAAAAAALHVLVPAWVYEHLAGQIVLGVITMAVLAVVLALCSEADAFVAASLTMLPLLPRLVFLVVGPAVDVKLFAMQAGMFGRAFAIRFAPATFVVATLVATAVGLIVLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN00</accession>
    <name>A0A132PN00_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849713.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09300"/>
    <dbReference type="EnsemblBacteria" id="KWX23422">
        <property type="protein sequence ID" value="KWX23422"/>
        <property type="gene ID" value="AFM11_14100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6924"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="32297" checksum="EC97AA6DCF1FA66C" modified="2016-06-08" version="1">MHTDELSWFVVLAETEHVTDAATELGISQPTLSRALARIEEQVGVPLFDRVNRRLRLNGYGEILLEHARRSIAEMRSATERIAALRDPDSGTVRLAFLHSQASWFVPDLLRRFRAEAPRVQFGLVQGAAHEIVERLAGGQADLAITSPRPEGYRWRGLYIERLCLAVPRGHRLASRNRVKLADAGNEPFVALAPGFGLRQLTDELCAEADIDPDVVFEAMEIPTMEGLVAAGFGVAVVPVPRPERAEPGAVYLPLSQASAKRQLGLAWSADRSLPPAAERFADFVIRTTHDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN60</accession>
    <name>A0A132PN60_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849397.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03755"/>
    <dbReference type="EnsemblBacteria" id="KWX23778">
        <property type="protein sequence ID" value="KWX23778"/>
        <property type="gene ID" value="AFM11_13470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6788"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="208" mass="22672" checksum="389A51A79DD33369" modified="2016-06-08" version="1">MTVTPMFPLEVAMLPGEELPLRIFEPRYVAMVGDCMAMPEPAFGVVLIAAGREVGGGDQRCDVGALARIVDCQNLGAERFRLACVMGERIRVLRWLDDDPYPRAEFELWPDEPGDPVDAAQIAGIEDRMVALFDRIGEAKGMTVHSREIVAAARLDPANHLYALAARLPMGQADRYSVLSAPTEAARLAALSEAVDTVTAMVEFQLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNF5</accession>
    <name>A0A132PNF5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_13030</name>
        <name evidence="2" type="ORF">AWC31_03315</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849580.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03315"/>
    <dbReference type="EnsemblBacteria" id="KWX23871">
        <property type="protein sequence ID" value="KWX23871"/>
        <property type="gene ID" value="AFM11_13030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11313">
        <property type="protein sequence ID" value="ORX11313"/>
        <property type="gene ID" value="AWC31_03315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6699"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="255" mass="28546" checksum="B7C8EB0EA0110E8E" modified="2016-06-08" version="1">MKSGEVELDFAREWVEFYDPDDAEHLIAADMTWLLSRWTCVFGTPACQGTVEGRPDDGCCSHGAFLSDDDDRARLDDAVKQLTDDDWQFREKGLGRKGYLEDDEYDGKPNLRTRKYKGACIFLNRPGFRSGIGCALHSKALKLGVEPLTMKPDVCWQLPIRRSQDWVTRPDGTQILKTVITEYDRRGWGEGGADLHWYCTGDPAAHVGAKQVWESYAPELTAVLGEKAYAELAAMCKRRSSLGLIAVHPATRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNJ4</accession>
    <name>A0A132PNJ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_11030</name>
        <name evidence="9" type="ORF">AWC31_31225</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848016.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23911">
        <property type="protein sequence ID" value="KWX23911"/>
        <property type="gene ID" value="AFM11_11030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12453">
        <property type="protein sequence ID" value="ORX12453"/>
        <property type="gene ID" value="AWC31_31225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6282"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="8"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX12453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="440" mass="47051" checksum="C4B9D19F54850744" modified="2016-06-08" version="1">MLTPAKKATLGSFVGTTIEWYDFFIYGTASALIFRHVFFPSHDPLVGTLLSFATFGVAFVARPLGGLIVGHFGDRVGRRPMLVMTLIVMGTATGAIGLLPTYESIGVMAPVLLVCLRFVQGLSVGGEYGGAVLMTVEHAPKHRRGLYGSWVQAGSPAGQIIANGVFLITTGMMSEEQLVAWGWRIPFLASFALVIVGLVIRLRVEESPEFKRLERRNEKEASPLMSVLRQYRKQVILMAGAYLVHGVVIYGAAVYSLSYGTTTLDFSYSQMLLLILLCQVVTLILIPTFAHLADRVGIKKVFLIGNIGMGLMGVPWVLLLDTGSFALALLGYLLIFTPYAATYGTMAAFFASIYDSRVGYSGISMGYQLGSIFGSGLTPLAAAALIASTGTVLAFAGYIAVAAALSVAATIWLTAFEDEESDETPRPATPAGEAAVTHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNK4</accession>
    <name>A0A132PNK4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_11115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848050.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23921">
        <property type="protein sequence ID" value="KWX23921"/>
        <property type="gene ID" value="AFM11_11115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6300"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="114"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="344" mass="36264" checksum="B4554D7A5275A361" modified="2016-06-08" version="1">MPIDLRSDTLTKPDKAMRAAMAAAEVGDDGRRGFNGRGEDPTVRELEDLAAALTGKECALFVPSGTMGNILGVLAQTAPGDTVAVSAHTHIRSNEGALFDESYFRRQPVAMSWESPALVCLENTFAATGGRCLRQDELDRASSLRMAGTRIHLDGARLFNAAAASGTPVATLSTVADTVTFCLSKGLGAPVGSLLCGDRSTIDCARSLRRYIGGAMRQAGVIAAAGLVALHPDNVARIAEDHVRAQTLAASLRDLDAVRIIGDVETNIVRVELPPKLDAQRVVARAAENGVLLRAVGDNAIRAVTYRDVGDADIATAARVWVRAIRAEEQSAGLRKSQNTQAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNP7</accession>
    <name>A0A132PNP7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23960">
        <property type="protein sequence ID" value="KWX23960"/>
        <property type="gene ID" value="AFM11_11325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6342"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="26"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="427" mass="46956" checksum="954AE346F96D4253" modified="2016-06-08" version="1">MQSQHLRNYRDRSAAGLNFSRQIIASCEVPGQCDIAAMDHAVNAYLRRHDTFRSWFEETDSGKFVRHSIEDPADIEFVAVDHGPMTVDEIREHVVAIPNPLEWGCFTFGIIQNDNFFTFFAAMDHVHGDATLIGTTMMEANGMYSALSGSGQALSLPDAGSFDDFCVREREYASALTLDSPGVRAWLDFAENNSDGFPEFPLPLGNPHESTRSDMTSELLMDAAQTERFESACTAAGARFVGGLFACLGLVEHEFTGALTYYGLTPRDSRTAGDNFMTQGWFTGLIPITVPVAATSFGEAAWAAQSCFDSSLDMARVPYYRVLELAPWLNWPRPNFPVSNFLHGGAAPLNAILAAADMGLANNIGIYPDGRFSYQLTIYIFRYGEGTAMAIMHPDNPIARKSVTRYLNAMKSVSSRVADVGHWGRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP03</accession>
    <name>A0A132PP03_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848490.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10065"/>
    <dbReference type="EnsemblBacteria" id="KWX24060">
        <property type="protein sequence ID" value="KWX24060"/>
        <property type="gene ID" value="AFM11_11905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6460"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="111" mass="12553" checksum="56C9633294BCB9EE" modified="2016-06-08" version="1">MAEPMLPSAFAELEPYAETWCLATETERWNARLSSTMPQMEQFYDAFFPRLEEAIDYCDKFPLDGLPDDALNLLHLIYSLIMVAMSVEIMHQPAPVDAADAVMIRTGEPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP11</accession>
    <name>A0A132PP11_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Microcompartment protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848550.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09970"/>
    <dbReference type="EnsemblBacteria" id="KWX24079">
        <property type="protein sequence ID" value="KWX24079"/>
        <property type="gene ID" value="AFM11_12005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6480"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044870">
        <property type="entry name" value="BMC_CP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51931">
        <property type="entry name" value="BMC_CP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC circularly permuted" evidence="1">
        <location>
            <begin position="23"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="BMC circularly permuted" evidence="1">
        <location>
            <begin position="125"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="225" mass="24407" checksum="2199330057C29455" modified="2016-06-08" version="1">MAPPDTVTETAREPGIRTQIRVYLLVEDLQRQFAAYLGTPTRARGYPPYEGEHALIVEVSPALAIERVIDLALREVPGVQPGILYVERQFGVLEIHSANLDDVRRAGEAILAGTGNKAADQLRPRVLYHDIIEDITDQHAVILNRNRQASMILPGQSLLVYEMTPALFAAVAANEAERAAPGLTVVDVQMIGAAGRLYIGGSTADVTLARDRITAVLAGIEGREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP39</accession>
    <name>A0A132PP39_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ORF">AFM11_11820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848442.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30225"/>
    <dbReference type="EnsemblBacteria" id="KWX24044">
        <property type="protein sequence ID" value="KWX24044"/>
        <property type="gene ID" value="AFM11_11820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6443"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045926">
        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006226">
        <property type="entry name" value="Mtu_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00028">
        <property type="entry name" value="Mtu_PIN_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="143" mass="16353" checksum="735F825887A58120" modified="2016-06-08" version="1">MLCVDVNVLVYAHRPDLPEHADYRSLLERIANGDEPLGLPDIVLSGFHRVITNRRVFTEPTNPQQAWEAIDALVAAPAALTVRSGERHWQLFRQLCEDIAAHGNDVQDAYLAAYALENNATWLSADRGFARFRRLRWRHPLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPA8</accession>
    <name>A0A132PPA8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Taurine catabolism dioxygenase TauD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848493.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10060"/>
    <dbReference type="EnsemblBacteria" id="KWX24179">
        <property type="protein sequence ID" value="KWX24179"/>
        <property type="gene ID" value="AFM11_11910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6461"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="4">
        <location>
            <begin position="6"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="281" mass="31138" checksum="774FBB7BBB4C0214" modified="2016-06-08" version="1">MSVLTINKLTTSVGAEVCGVDPDRLASDSGLGAAILDALEDNGVLVFHDLHLEPEAQVAFSQRLGEIDRSADGHHPVSGIYPITLDQSKNKAAEYLKATFDWHIDGCTPLHDECPQKATVLSALQVAARGGETEFANSYAAYDTLEDSEKERYENLRVVHSLEASQRRVYPDPTPEQLQRWQSRPTHENPLVWTHRSGRKSLVLGASADYIVGMDRDEGRALLAELLEHATTPDKVYSHKWSVGDTVIWDNQGVLHRAAPYEPNSPRHMLRTTVLGDEPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPF9</accession>
    <name>A0A132PPF9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobB</name>
        <name evidence="6" type="ORF">AFM11_09525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847148.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05700"/>
    <dbReference type="EnsemblBacteria" id="KWX24228">
        <property type="protein sequence ID" value="KWX24228"/>
        <property type="gene ID" value="AFM11_09525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5942"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01967">
        <property type="entry name" value="Sirtuin_ClassII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026587">
        <property type="entry name" value="Sirtuin_class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="242"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="280" mass="29760" checksum="D19C74FC04315A9A" modified="2016-06-08" version="1">MDAPELVTLLQGRRVAVLTGAGMSTDSGIPDYRGPDSPPSNPMTIRQFTSDPVFRQRYWARNHIGWRHMDDTQPNAGHRALAALEASGVVTGLITQNVDLLHTKAGSRDVVNLHGTYAQVVCLDCGHTMARSTLADLLEQANPGFLERAETVGGIAVAPDADAVVTDTASFVIVDCPVCGGMLKPDIVYFGENVPKERVEQAYSVVDAAQVLLVAGSSLTVYSGYRFVRHAAARGVPVAIINRGPTRGDDLATVKVDAGCSEMLTLLAGELVRTYTASPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPM5</accession>
    <name>A0A132PPM5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847240.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05545"/>
    <dbReference type="EnsemblBacteria" id="KWX24255">
        <property type="protein sequence ID" value="KWX24255"/>
        <property type="gene ID" value="AFM11_09680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5974"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="131"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="335" mass="35216" checksum="2021ADC71ADF88EF" modified="2016-06-08" version="1">MTTLGVIGLGRIGAFHVDTLSGLDGIDGLVVADERPDVVAAVAAKHGAKPADSVEDLLDSGIDGVVVAAATPAHAELTLAAVGRGLPTFCEKPIASTAAESAHVAEVIARSGVPVQVGYQRRFDAAFAAAKRAVDSGSLGHLHTVRSTTMDPAPPPMDYIKGSGGIFRDCAVHDFDVLRWITGQNAVEVYATGTVQGDPRFAEYGDVDTAAVVVKFDGGALGIVSAARYNARGYDCRLEVHGFNDTVVAGWDQGAPMQNMDPRNDFPAGPYHHFFMDRFTEAFRTELAAFVSVVKGEAIPGATVADAVEVAWLAEAATESLRRGTPVRIEEVRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPN1</accession>
    <name>A0A132PPN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_09980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847391.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05245"/>
    <dbReference type="EnsemblBacteria" id="KWX24306">
        <property type="protein sequence ID" value="KWX24306"/>
        <property type="gene ID" value="AFM11_09980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6032"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="26383" checksum="8A867E96C39E1B7B" modified="2016-06-08" version="1">MIDVDGLRLSFGDTEVLHGVSCRVAEREVVCIIGASGSGKSTLLRCMNGLERPSHGTIVINGHTLGPQEKTADLAVVRRDMGMVFQHFNLFPHMTVIENIALAPRRVLGRNKTDAEERARTLLGRVGLADKADVYPDSLSGGQKQRVAIARALAMDPKIMLFDEPTSALDPEIVGEVLAVMKDLAADGMTMVVVTHEMGFAREVSDRVMYMDKGMIVETASPASLFSSPQETRTREFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPQ9</accession>
    <name>A0A132PPQ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847441.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18555"/>
    <dbReference type="EnsemblBacteria" id="KWX24321">
        <property type="protein sequence ID" value="KWX24321"/>
        <property type="gene ID" value="AFM11_10070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6050"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016601">
        <property type="entry name" value="UCP012637"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012637">
        <property type="entry name" value="UCP012637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="217" mass="23191" checksum="75B4CEE0D55408BB" modified="2016-06-08" version="1">MTGPERGLWVEDPRHREDLMAFVERALRLDEAAVVRLRERAPELVVAWVATGFDVLASRVVSARVRPSDLSAGADALAAGLSAPGGYVDPGFPMDSAWRGGLPPEAGFAHLDDVPARVMLDLAQQGIALAREHSSAHGPPASLLDQEVVGVSADDVSVGIPMRCVFALTAMGFLPQSGDEVSADEIVRVRAHPAWLRIDARFGSVYRRRGGDPALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPR7</accession>
    <name>A0A132PPR7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_10145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847480.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24331">
        <property type="protein sequence ID" value="KWX24331"/>
        <property type="gene ID" value="AFM11_10145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6065"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="386" mass="42562" checksum="D0483D2087122B11" modified="2016-06-08" version="1">MTASTGEAPQIRKGLAGVVVDTTAISKVVPETNTLTYRGYPVQELAAQCSFEQVAYLLWHGELPDDQELALFNQRERASRRLNRSMLSLLAKLPDSCHPMDVVRTAISYLGAEDPDEDDSSVAANYAKSLRMFAVLPTIVAADMRRRRGQDVIAPHSHLGYAQNFLNMCFGEVPDPVVVEAFEQSMILYAEHSFNASTFAARVVTSTRSDIYSAVTAAIGALKGSLHGGANEAVMRDMLAIGSADRAPEWLHAKLSRKDKVMGFGHRVYRNGDSRVPTMRDALYRVAAICDGRHWLDIYESLEQNMLAATGIKPNLDFPTGPAYHLMGFDIPSFTPIFVMSRITGWTAHVMEQAASNALIRPLSDYSGPPQRALVRDRVNGQSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPW4</accession>
    <name>A0A132PPW4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12020</name>
        <name evidence="3" type="ORF">AWC31_09955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848560.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09955"/>
    <dbReference type="EnsemblBacteria" id="KWX24082">
        <property type="protein sequence ID" value="KWX24082"/>
        <property type="gene ID" value="AFM11_12020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09253">
        <property type="protein sequence ID" value="ORX09253"/>
        <property type="gene ID" value="AWC31_09955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6483"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="255" mass="27080" checksum="4B273CC485C6E504" modified="2016-06-08" version="1">MAIQSEELRRRIVADINAGAPGAKLGSERDLADRYGTSRSSLRQVLAALEEAGLVHRVIGRAGGIFISHGQVERNLSDVVGVPAFLANQGYIAGTRVLSTRITTPDQATRTALRLGPGDYVVEIQRVRLADGSPISLEHAQFPADAFPGLLEQQLGGSLYEILESQYGKVAGRADERIEAVNATSSEATLLGIKPKAALLLITRVTYDQDGSPCEFSRDLFRGDRTALAVTAKGQGIAAQADANTASVTLQRQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ25</accession>
    <name>A0A132PQ25_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847783.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19275"/>
    <dbReference type="EnsemblBacteria" id="KWX24429">
        <property type="protein sequence ID" value="KWX24429"/>
        <property type="gene ID" value="AFM11_10760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6191"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="261" mass="26618" checksum="91BFBC9027664DD9" modified="2016-06-08" version="1">MRTYFDLTGRSALVTGAGAGIGAAVSEALAAAGAAVLVTDISGDAAARVAERINAAVGDGKFSTAGGKADSAPLDVSDRDAAVAATERAAGLGEGKLHILVNNAGVTSPAMFPKLTDETFRLTFDIHVMGTFHVTQAALPHIPTDGTGRVINVTSSAGITGTLGQVNYSAAKAGLIGFTKSLARELAPKNIMVNALAPLAATPMTETIRTNEKFAANMMNRIPLKRWAEADEVAGAFVFLASDAASYITGQVLPVDGGMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ55</accession>
    <name>A0A132PQ55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24337">
        <property type="protein sequence ID" value="KWX24337"/>
        <property type="gene ID" value="AFM11_10175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6073"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453491" evidence="2">
        <location>
            <begin position="31"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="202" mass="19836" checksum="88C00969EC55E97A" modified="2016-06-08" version="1">MRSSNLCGRGLAVLGVALGIGIALGPTASADPDAVVQTEAGAVAPAPAAPAAPAAVPDRTAPAPDPMAAGPVPAGDANPAAVAACSLFAEALDNASVFYGDFADTIDGSTRPDYSDPIVSTTNVSGRTALRESAAKAMNAAGTPGLSPDIAGPMRAWSMDATKLLLKMGLRGSGDTLNVTASELNDDAHNAQMACALAGTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ79</accession>
    <name>A0A132PQ79_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847547.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18720"/>
    <dbReference type="EnsemblBacteria" id="KWX24490">
        <property type="protein sequence ID" value="KWX24490"/>
        <property type="gene ID" value="AFM11_10275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6093"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF853" evidence="2">
        <location>
            <begin position="36"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="523" mass="55400" checksum="E7D94ED0C5C7D153" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQB0</accession>
    <name>A0A132PQB0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845953.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24519">
        <property type="protein sequence ID" value="KWX24519"/>
        <property type="gene ID" value="AFM11_07455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5339"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453496" evidence="1">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="79" mass="8056" checksum="8BFE6D717B70DFDE" modified="2016-06-08" version="1">MNRSKLMRAAALGLGALAVPVGVAVAGAAPAAAGPEICATGPYGYVTACVEGPGWIRPWYDDGPHWRGHGRGHGHGHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQG2</accession>
    <name>A0A132PQG2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amine oxidase</fullName>
            <ecNumber evidence="10">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_07745</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58001"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9 10">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846103.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24370"/>
    <dbReference type="EnsemblBacteria" id="KWX24568">
        <property type="protein sequence ID" value="KWX24568"/>
        <property type="gene ID" value="AFM11_07745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5398"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052595">
        <property type="term" value="F:aliphatic-amine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052594">
        <property type="term" value="F:aminoacetone:oxygen oxidoreductase(deaminating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052596">
        <property type="term" value="F:phenethylamine:oxygen oxidoreductase (deaminating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary amine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052593">
        <property type="term" value="F:tryptamine:oxygen oxidoreductase (deaminating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="PTHR10638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="SSF49998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="SSF54416"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0186">Copper</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Cu_amine_oxidN2" evidence="13">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN3" evidence="14">
        <location>
            <begin position="110"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxid" evidence="12">
        <location>
            <begin position="231"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="8">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="9">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX24568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="641" mass="71684" checksum="3107A5E25ED755BD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQH4</accession>
    <name>A0A132PQH4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_07865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846162.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24475"/>
    <dbReference type="EnsemblBacteria" id="KWX24590">
        <property type="protein sequence ID" value="KWX24590"/>
        <property type="gene ID" value="AFM11_07865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5424"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453243" description="Histidine kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="237"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX24590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="446" mass="47848" checksum="C3FEB346767E27DD" modified="2016-06-08" version="1">MSLLARIFRRTPSLRTRVAFATAIGAAIVVVIVGTIVWVGITNDRKERLDRRLDEAAGFAIPFLPRGLDQIPRSPNDQDAVITVRQTGSVTSNSTVVLPELPAGYADTYIDGVRWRVRTVEIPAPGPMWVAVGATYDATIADTNNLHRRVIVICVFAVGAATVLGWVLAAFAVRPLKRLAEQTRQIEAGDEAPDVEVRGATEAVEIADAVNGMLKRIWKEQDRTKAALASARDFASVSAHELRTPLTAMRTNLEVLATLDLPDEQRKEVVNDVIRTQSRIEATLGALERLAQGELTTTDDHVTVDITELLDRAAHDAMRVYPELDVSLAPSPTVIIVGLPTGLRLAVDNAIANAVKHGGATRVQLSAVSSREGVEIAVDDDGCGVPEEERKLVFDRFSRGSTASRSGSGLGLALVAQQAELHGGTASLESSPLGGARLLLRLPGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQJ9</accession>
    <name>A0A132PQJ9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">AFM11_07985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846221.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24585"/>
    <dbReference type="EnsemblBacteria" id="KWX24611">
        <property type="protein sequence ID" value="KWX24611"/>
        <property type="gene ID" value="AFM11_07985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5447"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="254" mass="25951" checksum="EAE742EF97EDE0FE" modified="2016-06-08" version="1">MVELKTKDEVEAMASAGAVVAEALRAVVAHGAPGHTTADLDRIAAEVLASHGATSPFLNYHPRWAPSPFPAVLCVSVNDAVVHGVPNGQVLADGDLVSVDFGAILNGWCGDAARSFVVGTPRPADTALIEATDAALAAGIAAVRPGNTLGDIGHAIASVARGAGYGQLADHGGHGIGRTMHEDPHVPNEGRPGKGMKLRPGMVLAIEPMLIADGTDDYLHDSDGWTLRTATGARAAHSEHTVAVTADGARILTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQL3</accession>
    <name>A0A132PQL3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07995</name>
        <name evidence="3" type="ORF">AWC31_24595</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000014">
        <property type="protein sequence ID" value="ORX15207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846226.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24595"/>
    <dbReference type="EnsemblBacteria" id="KWX24613">
        <property type="protein sequence ID" value="KWX24613"/>
        <property type="gene ID" value="AFM11_07995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15207">
        <property type="protein sequence ID" value="ORX15207"/>
        <property type="gene ID" value="AWC31_24595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5449"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021421">
        <property type="entry name" value="DUF3071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11268">
        <property type="entry name" value="DUF3071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="262" mass="28078" checksum="72A77256F5F9870C" modified="2016-06-08" version="1">MRALRVVGLDVDGKRIICEADDSTEMFSLRVDDRLRAAVRGDKVASNQTQIDVEVQSVLRPKEIQAKIRAGASVEQLAAAAGVPVERVERFAHPVLLERARAAELATAAHPVLADGPAVLTLLEMVTTALVARGLDPDAAAWDAWRNEDSRWTVQLTWKAGRSDIQAHFRFTPGAHGGTVTASDDAAQQLINPDFGRPLRPVAAVPELDFEAPAPPVATPEPAAAEPEPEAAPAPKRGRKARPAVPAWEDVLLGVRSSGTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQP8</accession>
    <name>A0A132PQP8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Creatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846369.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24659">
        <property type="protein sequence ID" value="KWX24659"/>
        <property type="gene ID" value="AFM11_08260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5503"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="163"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="384" mass="41358" checksum="F5E3DB519B930F1C" modified="2016-06-08" version="1">MPQLAFPLTTYRARLTDVQARMRAAGLDAMVITMPDAVHWLTGVDSVGYLWPQGLVVPADEGGQPVFVTRTTEQPGVDACSWLTERRFYDISVTDPVDALIDAVAEAGLGNTRLGLETDAFTMLPSTYLRIVEAFPDAKFSDCSYIVPEARLVKTEAELAYQRQAAAIADHAMRQVLAEVRPGVSELELAGIAARALGEAGGEHAAIPPMVVSGERSALVHCMAGRRVLGRGDVVCIELAGVVNRYHAVLMRTAVIGTPNPRVQEVAELQKQAHLAAVARTAPGVAVHEPEDAAREVLEPAGLHANRCHRIGYSLGVAYPPGWLEPMTMVQGDEHVFVPGMSFTVEPNLHLPEEGFGLKLGETVECTADGPRSMTTLDHDIFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQQ4</accession>
    <name>A0A132PQQ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846350.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24653">
        <property type="protein sequence ID" value="KWX24653"/>
        <property type="gene ID" value="AFM11_08230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5497"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453501" evidence="1">
        <location>
            <begin position="27"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="37421" checksum="952B8300DAF193E8" modified="2016-06-08" version="1">MRSRSLSVALGAIAVLSLSSCSGSTGSGMQLTFASYGSAYQDAQNEALLDPWAGESGATVTNDSPTSYPKIAQMVDANQVTWDVVDTEPFYPVANCGKYVEKLDLTGIDVTKFPKGTVSECSIPFAQYSTVMVYDREKYPQGPASYADFFDLQKFPGVRMVPNWAGGGALELALLADGVAPQQLYPLDIERAFAKLDTIRDSLRFWNTSSESQQALEDGTVDMAFVWSGRAYEAEKNGAKLEPVWQNNLLAWASLSIVKGAKNLDAAQSLIEYAATAEPQAKFAELQPYSPANSDAKPELDELQQKYNVASPEIQHEAVITDVQYWADHNDEANKAWTAWSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQZ3</accession>
    <name>A0A132PQZ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_10940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847878.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19455"/>
    <dbReference type="EnsemblBacteria" id="KWX24462">
        <property type="protein sequence ID" value="KWX24462"/>
        <property type="gene ID" value="AFM11_10940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6227"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="82"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="237" mass="25209" checksum="B706997044F25558" modified="2016-06-08" version="1">MPAKASQSSTDGAPNGAPGSQTLARGLSALSAIASAPTGLTVQQVADHLGAHRTIAYRLLATLSQFRYVAKGEDGRYRPAAALAVLGSSYDNNLRQLSVPRLRALADELGTTVSLLVAEGDQQVAIAVIVPTQVFYQLSFHEGSRHPLDRGAAGVALLASMPPRPGERDLVRQTREQGWVITHGEIEPNTYGLAVPVRRRPPSPPTCINLISHREDVVLDGKDAVVRAAHELSAILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR35</accession>
    <name>A0A132PR35_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_08715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846580.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13655"/>
    <dbReference type="EnsemblBacteria" id="KWX24734">
        <property type="protein sequence ID" value="KWX24734"/>
        <property type="gene ID" value="AFM11_08715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5593"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="181" mass="19126" checksum="51EBC54DE99D15BD" modified="2016-06-08" version="1">MGYHHGDLKAVILEQAAALVAERGADGISLRELARAAGVSHAAPAHHFTDRRGLFTALAAEGCRLLAEALNGARPQFIDAAKAYVRFALDHPGHYEVMFDKSLYDDADAELVEAAAAAGFELNRGVGTLTDPKAKADPDAAALAAWSMVHGFSLLWLNDAIDTSGDPIGTVEKMGKILFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRA0</accession>
    <name>A0A132PRA0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08705</name>
        <name evidence="2" type="ORF">AWC31_13665</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846982.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13665"/>
    <dbReference type="EnsemblBacteria" id="KWX24853">
        <property type="protein sequence ID" value="KWX24853"/>
        <property type="gene ID" value="AFM11_08705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18572">
        <property type="protein sequence ID" value="ORX18572"/>
        <property type="gene ID" value="AWC31_13665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5591"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018763">
        <property type="entry name" value="DUF2334"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10096">
        <property type="entry name" value="DUF2334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="234" mass="25699" checksum="9B3970C5586A520E" modified="2016-06-08" version="1">MTGQLIVSISQISDRTLDDVASFCAELDARGVPASLLVAPRLKGGYRLDRDAPTVEWLTARRVGGDAVVLHGYDEAATKKRRGEFASLPAHEANLRLMGADRVLEHLGLRTRLFAAPGWNASQGTVAALPRNGFRLLAELNGVTDLVRRTTVRARVLGIGEGFLTEPWWCRTLVLSAERTARREGVVRVAVAARHLRRPGPRQAMLDAIDLALLHRSVPGVYRWRPYPVLTDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRZ7</accession>
    <name>A0A132PRZ7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06535</name>
        <name evidence="5" type="ORF">AWC31_29140</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845337.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29140"/>
    <dbReference type="EnsemblBacteria" id="KWX25075">
        <property type="protein sequence ID" value="KWX25075"/>
        <property type="gene ID" value="AFM11_06535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13849">
        <property type="protein sequence ID" value="ORX13849"/>
        <property type="gene ID" value="AWC31_29140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4501"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01340">
        <property type="entry name" value="UPF0353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022933">
        <property type="entry name" value="UPF0353"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="98"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX13849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="335" mass="35682" checksum="F3ADF763C97D6640" modified="2016-06-08" version="1">MTLPLLGPMSLSGFAHAWWFLFLIVVAGLVALYIAVQRARKQRILRFANMELLESVAPKQPTRWRHVPAILLVSSLVLFTIAMAGPTNDVRIPRNRAVVMLVIDVSQSMRATDVSPSRLVAAQEAAKQFADQLTPGINLGLIAYAGTATVLVQPTTNREATKNGLDKLQLADRTATGEGIFTALQAIATVGAVIGGGDEPPPARIVLMSDGKETVPSNPDNPKGAFTAARTAHDQGVPISTVSFGTPYGYVEINDQRQPVPVDDDMLKKIAQLSGGDAFTASSLEQLKAVFTSLQQQIGYETIKGDASVGWLRLGALVLALAGVAALLINRRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PST3</accession>
    <name>A0A132PST3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844051.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21650"/>
    <dbReference type="EnsemblBacteria" id="KWX25355">
        <property type="protein sequence ID" value="KWX25355"/>
        <property type="gene ID" value="AFM11_03500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2574"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="129" mass="14311" checksum="D5932BB6B25AEB1F" modified="2016-06-08" version="1">MGSFLLRAVLTGFALWVVTLIVPGMSFVGGDSTLTRVGIIFVVAVIFGLVNAIIKPIVQILSIPLYILTLGLIHIVINALMLWITSWITEHTTHWGLQIDDFWWTAIWAAIVLSIVSWLLSFVHRAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSX1</accession>
    <name>A0A132PSX1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25410">
        <property type="protein sequence ID" value="KWX25410"/>
        <property type="gene ID" value="AFM11_03860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2649"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="59" mass="5926" checksum="00ABB149EF134C85" modified="2016-06-08" version="1">MGFGIALAFAPAGWAEPATPTTPAVPSETSTTDELTDMVLDALEQGPATSTAPAPRPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSX7</accession>
    <name>A0A132PSX7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-ketoadipyl CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_03120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843854.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25297">
        <property type="protein sequence ID" value="KWX25297"/>
        <property type="gene ID" value="AFM11_03120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2495"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="267"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="396" mass="41156" checksum="FA8D1CB86FE25356" modified="2016-06-08" version="1">MHHSYVYAAARTPFGRFNGALASYRPDDLSAHALAAVVNKVPALSGERIDDVVWGCANQAGEDNRNVGRMAVLLAGLPTSVAATTVNRLCGSSLDAVIMGSRSVETGDAQVVVAGGVESMTRAPWVLPKPARAFPTADATAVSTTLGWRLVNHNMPERWTLSLGACNELLAHRFSIERARQDEFAAQSHQRAHAAWESGFYDPLVVAVDGLTRDEGIRPDSTAEALAALKPAFHPDGTITAGNASPLNDGAAAVLIANADADLGIDPQARIAGRASFALDPQDFGYAPVEAANRALARAGISWSQVGAVELNEAFAVQTLACVDAWKALGLSDPDIVNATGGAIAIGHPLGASGARVVGTLAHRLRTTGQRWGVAAICIGVGQGLAVVLDNVAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT97</accession>
    <name>A0A132PT97_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choloylglycine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_03970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844297.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21185"/>
    <dbReference type="EnsemblBacteria" id="KWX25427">
        <property type="protein sequence ID" value="KWX25427"/>
        <property type="gene ID" value="AFM11_03970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2672"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBAH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="323" mass="35211" checksum="292616EE4B22300D" modified="2016-06-08" version="1">MCTRVLWNSNDLAVLTGRSMDWPESTEPLIVAFPAGRSRDGGLLAGHPVVAENPLRWTSRYASLATTVYGLGTVDGINSEGLGVHALYLRSTDVGPRNPDLPGLHTGVWAQYLLDQAATVEQALALMDGVQLVMVGARGREATLHLAIEDASGDSAILEMASGKLVVHHGRQYTLMTNDPTYDEQLALLAKQDFSHPSRELPLPGNVNPVDRFQRAAYYSALLPEPATIRQAVAGVMAIMRNVSVPFGAPYGDFGVYNTEYRTVSDLTQRLYFFELSTSPSTLWVEFDRLALPAGGQTLAIDPYDESLVGNVTERFTPRDIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTJ9</accession>
    <name>A0A132PTJ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844791.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25635">
        <property type="protein sequence ID" value="KWX25635"/>
        <property type="gene ID" value="AFM11_05260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2937"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="497" mass="54836" checksum="A86891E60E5727A2" modified="2016-06-08" version="1">MTSTAAAQRRAVFYLRISLDQTGEGLAVDRQRKECQRIARQRGWRVVGEFVDNSISASDARKNRPGYDALVKAYEAGEFDALVCYDMDRLTRQPRQMEDWLDAAEQRGLDLVTANGEADLTTDAGRTFVRVRMAFARGEVERKSARQKVAAAQRAKLGRPPLGVRLTGYTAKGETVPDEAELVRRIFKMFHSGESLRGIAAVLTAEGLAARNGRPWNPSSIRETLTNPRYAGRSIYNRLASEAAARKARTAGKAAEPLTVARGTWESLVSDDVFDAVQSRLTDPRRRTQQGTDRKHLGSGMFLCDSCGQPVVSFSGGRYRCKAACVNRAHGPVDHVRVRRIIAADDDRDAPLARGVDEFVTALVTERLSRPDAAKLLAAPTVDTAPLRAEQDRLRARLDTIDAEYDDGIIDGLRWRTAKEKVNAQLSEVDRKIRASTPGGGALGDMLAAPDPAEAFLAGSLMARRSVIDALCEVRLRRGTRGSKTFDPNTVRVEWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTQ6</accession>
    <name>A0A132PTQ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-ACP desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_04885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844664.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20260"/>
    <dbReference type="EnsemblBacteria" id="KWX25577">
        <property type="protein sequence ID" value="KWX25577"/>
        <property type="gene ID" value="AFM11_04885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2858"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="275" mass="31113" checksum="A336ADB4C15642F8" modified="2016-06-08" version="1">MAQKPVPNALTLELEPVVNAELRRHLDTEDLWYAHDYVPFDQGENFAFLGGKDWDPSQVTLPKNVTDALEILLITKDNLAGYHRELVEHFILEEKWGRFLGRWTAEEHLHAVALRNYLVVTREIDPTANEDVRVEHVMKGYRADTYSQIETLVFMAFFERSHAVYCRNLQAEVAEPVLKAMMGRIAADEERHEEFFANLVTHLLGTHRDETVGAIAARAAEFDVIGADIDAYQDKVALVAETGIFDKAALRTVISGRIAAWGLAGEPQLQEFTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUA0</accession>
    <name>A0A132PUA0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842491.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33945"/>
    <dbReference type="EnsemblBacteria" id="KWX25885">
        <property type="protein sequence ID" value="KWX25885"/>
        <property type="gene ID" value="AFM11_00915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.189"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="184" mass="20030" checksum="EB71DD0658BA39EC" modified="2016-06-08" version="1">MTTVVRVADRLVTFFAAAALLVAGAWLIGYRANVPVAREASARLDADAFASAPQWPWWPAALGVGGVVAALLGLWLVLLHMRPRSIRTVTGDTGAVDLDRLADAVADDLGRHPAVQRAKAVTRTERGRPVMRITAEVASHTPAEDVHRLARRCRADARRAAGTDFEFQLLIKQVRPEQARSRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUQ0</accession>
    <name>A0A132PUQ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propanediol dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pduC</name>
        <name evidence="3" type="ORF">AFM11_00985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842528.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34015"/>
    <dbReference type="EnsemblBacteria" id="KWX25897">
        <property type="protein sequence ID" value="KWX25897"/>
        <property type="gene ID" value="AFM11_00985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.203"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036999">
        <property type="entry name" value="Diol/glycerol_deHase_lsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003206">
        <property type="entry name" value="Diol/glycerol_deHydtase_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02286">
        <property type="entry name" value="Dehydratase_LU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dehydratase_LU" evidence="2">
        <location>
            <begin position="18"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="574" mass="61858" checksum="03E3AB77911333AB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV52</accession>
    <name>A0A132PV52_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843381.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35440"/>
    <dbReference type="EnsemblBacteria" id="KWX26154">
        <property type="protein sequence ID" value="KWX26154"/>
        <property type="gene ID" value="AFM11_02665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.547"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="328" mass="35813" checksum="C0AB2BB1210513AA" modified="2016-06-08" version="1">MTRFGYTLMTEQSGPKDLVRYAVSAEQVGFDFEVCSDHFSPWLATQGHAPNAWPVLGAVAHATEAVQLYSYVTCPTIRYHPAVVAQQAATLQILADGRFTLGLGSGENLNEHVVGRGWPTIERRLDMLAEAIKIIRELLTGELVDFRGEYFEVDSARIWDLPAEPLTIGVSMTGEKAVEKLAVAADHLINVAPDRKIIDEWRSLRQSTGVLPEGRVIGQIPVCWDTDRDAAVKRAHDQFRWFAGGWSVNADLPTPAGFAGATQFVRPDDVASSIPCGPDLDAIVAAVDEYREAGFTDIALVQIGGDSQERFLDEAAKPLLAALRADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV75</accession>
    <name>A0A132PV75_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843612.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34300"/>
    <dbReference type="EnsemblBacteria" id="KWX26236">
        <property type="protein sequence ID" value="KWX26236"/>
        <property type="gene ID" value="AFM11_01265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.259"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="214" mass="23160" checksum="1CE5E4A8DE8E53A4" modified="2016-06-08" version="1">MITASGLGVDGEHGPLFSNIDLELTPGFHAIQMPGGWGQTALLLTLAGRLKPTYGTVTVAGDTEPKAIRRHCSIAAFPDIDDLEESVTVQTVLAEQRRWLAPWYARVPAEAGEAALAEVFGELPAPSAKTYISELSDLELFLLRVTLARFSDRPILVVGDLEQVRDNSRRAIAVERLGVIAERRTVIVGVTNPLGSDAPDHGLHDHRILIGKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVA1</accession>
    <name>A0A132PVA1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-dimethylarginine dimethylaminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33245"/>
    <dbReference type="EnsemblBacteria" id="KWX26204">
        <property type="protein sequence ID" value="KWX26204"/>
        <property type="gene ID" value="AFM11_00135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.28"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="277" mass="30053" checksum="34FE7B199F1A603A" modified="2016-06-08" version="1">MPTDVAAPPHARKSSTRHYAMTAPEYFTVEYAINPWMDTSTPVDTERALAQWHELRGIYADLGHTVDLVTPRAGLPDMVYAANGGFLVARTAVVARFAYPQRAAEADAYAEWMARSGFEPLTTQHVNEGQGDLLLVGSTLLAGWGFRTDRRAHDEIAALTGLTVESLELVDPRFYHLDTALAVLDDTTVAYYPPAFSDASRERLRQLFGDAIEVSSADAYVLGLNVVSDGRNVVLPAAATGFAEQLRHAGFEPIGVDLSELLKGGGSVKCCTLELHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVL5</accession>
    <name>A0A132PVL5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mycofactocin system transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00170</name>
        <name evidence="6" type="ORF">AWC31_33280</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843547.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33280"/>
    <dbReference type="EnsemblBacteria" id="KWX26207">
        <property type="protein sequence ID" value="KWX26207"/>
        <property type="gene ID" value="AFM11_00170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12087">
        <property type="protein sequence ID" value="ORX12087"/>
        <property type="gene ID" value="AWC31_33280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.35"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023851">
        <property type="entry name" value="Tscrpt_reg_TetR-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03968">
        <property type="entry name" value="mycofact_TetR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX12087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="200" mass="22004" checksum="BD383747B9291720" modified="2016-06-08" version="1">MQGPGPRVGRRRSTTQDHIAGVAIELFAARGFDDVSVDDIAAAAGISRRTLFRYYASKSAIPWGDFDAHLQHLRELLATLSPQISLGEALREALLAFNTYAEHEMAEHRQRMRVILETEALQAYSMTMYAGWRDVIATYVAHRIGAEGSDLLPQTVAWLMLGVALSAYEKWLADESVSLTDTIAQAFEIARPGLDALGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVL8</accession>
    <name>A0A132PVL8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843113.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34960"/>
    <dbReference type="EnsemblBacteria" id="KWX26072">
        <property type="protein sequence ID" value="KWX26072"/>
        <property type="gene ID" value="AFM11_02180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.446"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="148" mass="16375" checksum="2483BA2E995D184C" modified="2016-06-08" version="1">MIATSATELRESMMAVTRQMRRHRPDHGLTLSQMELLGEVSRTGTTTPAELGARLHVRVQSLTDSINELLGRGLIARRPDDNDRRRQLIDITAAGTALLQADRAERDAWLHATMRDNLTDLEFDLLMLVAPVLRKLAYSEAGGGTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAY2</accession>
    <name>A0A132PAY2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859824.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02650"/>
    <dbReference type="EnsemblBacteria" id="KWX19495">
        <property type="protein sequence ID" value="KWX19495"/>
        <property type="gene ID" value="AFM11_35600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5856"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="219" mass="22842" checksum="D163E3F24FE1038B" modified="2016-06-08" version="1">MTDLGQLLAGIRFGDSAFPSGGFAFSSGLEGSHRDGLVCDEDDVTAFAAEQLSGRWHSCDRVLMRLAWPQLDPQGTDELAEALASMAVLRQASRRAGAATLATFQAVVDHGVTDYRTRVLAGSAPGHLPVAQAVCFRAAGLGLDTAEAVSAWQVVSGITSAALRLGICGHLGAQRVLTALSPALLDVLRREPPGEPAAFTAFADIAAQRRGDGVRLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB40</accession>
    <name>A0A132PB40_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35670</name>
        <name evidence="6" type="ORF">AWC31_31585</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000046">
        <property type="protein sequence ID" value="KWX19477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859899.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31585"/>
    <dbReference type="EnsemblBacteria" id="KWX19477">
        <property type="protein sequence ID" value="KWX19477"/>
        <property type="gene ID" value="AFM11_35670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12514">
        <property type="protein sequence ID" value="ORX12514"/>
        <property type="gene ID" value="AWC31_31585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5869"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX12514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="239" mass="25926" checksum="699C9C9B39F8F612" modified="2016-06-08" version="1">MPLLDVENLTSGYGRNNIIRGVTLSAEHGSITAIIGPNGAGKTTLVQTIAGVVDARGGSVTLDGENLEGMSARERARRGLGYTPQLRNVFGALSVEDNLEVVTRAMRLPRERLDEVFETFPILAERRKQRAGTLSGGQRQQLAIASSLLMRPQLLILDEPTTGLAPQIVDSLIEQICRIERGGTGVLWVIEEHPSQILPLCKRVFLMDSGQIRHEASGPELLADPNFAEIFLGARIPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC01</accession>
    <name>A0A132PC01_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858868.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07990"/>
    <dbReference type="EnsemblBacteria" id="KWX19824">
        <property type="protein sequence ID" value="KWX19824"/>
        <property type="gene ID" value="AFM11_33765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5090"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022492">
        <property type="entry name" value="Phosphomutase_MSMEG4193_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03848">
        <property type="entry name" value="MSMEG_4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="223" mass="23661" checksum="5206253A2EED1532" modified="2016-06-08" version="1">MTLILLRHGRSTSNTAHTLAGRSEGVDLDDRGVEQAEGVVSRIGDLPVRAIVRSPLLRCRRTVEPLAAALGLEPIVDEGLTEVDYGGWTGRKIADLVKEPLWSVVQAQPSAAVFPDGEGLAQVQARAVAAVRRRDRELAEAHGADVLWVACTHGDVIKAVLADALGVHLDGFQRITADPASMSVIRYTDLRPFVMHINHTGAQLSAGLAAKPTTDAVVGGSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC36</accession>
    <name>A0A132PC36_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_33465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858712.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19890">
        <property type="protein sequence ID" value="KWX19890"/>
        <property type="gene ID" value="AFM11_33465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5025"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="79"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="179"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="406" mass="44719" checksum="EB766F2E18AC4FAA" modified="2016-06-08" version="1">MSRNEWGKIKKQPTKTPSYQASYIGVDGRRHYAPHTFTSKTFAQGWLANERAYKERCTLSGERWKSPGERATEKKAKVLTFGEYGKRVIDERKLSPRTRDLYESQWAQLIEPTFGKLAVSDVSPSAVRAWFSSLDSAKERRNSQAYGVLSMICNTAIRDGLIERNPCMIQGAMTTMAKKNVKIPTTVELHAIADKLGAEPRYERFKALVLLAGWCGLRIGEATELRRKDFDADCTVVSITRGVTHRGGKCLLGPTKTKETRDVDIPPHIQQDIIDHLNRFVGTSPDALLFEPARGGCHLNDRVFNKDIFQKAAKTVGREDLSAHDLRRFAGSKNAQVGATLAENMKRLGHSTVKAALLYQHSYDDSGKKLAANLSASALAEIAAAADSIAEAADSIAAADHAVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC78</accession>
    <name>A0A132PC78_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetaldehyde dehydrogenase [acetylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_33075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:23288"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the acetaldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858480.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17150"/>
    <dbReference type="EnsemblBacteria" id="KWX19929">
        <property type="protein sequence ID" value="KWX19929"/>
        <property type="gene ID" value="AFM11_33075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4947"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01657">
        <property type="entry name" value="Ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003361">
        <property type="entry name" value="Acetaldehyde_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015426">
        <property type="entry name" value="Acetylaldehyde_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09290">
        <property type="entry name" value="AcetDehyd-dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015689">
        <property type="entry name" value="Actaldh_dh_actl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03215">
        <property type="entry name" value="ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="4">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="158"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="309" mass="32393" checksum="7192F0D4D1C84FA8" modified="2016-06-08" version="1">MANKASVAIVGSGNISTDLLYKLLRSEWLEPRWMVGIDPESEGLARARKLGLETSAEGADWLLGLDEKPDLLFEATSAYVHRDAAPRYAEAGIRAIDLTPAAVGPGVIPPANLRAHLDAPNVNMVTCGGQATIPIVHAVSRVVDVPYAEIVASVSSASAGPGTRANIDEFTKTTSAGVQNIGGAQRGKAIIILNPAEPPMIMRDTIFCAIPEDADHDAIAQSIKDVVAEVQTYVPGYRLLNEPQFDEPSVVNGGNHLVTTFIEVEGAGDYLPPYAGNLDIMTAAATKVGEEIAKEKLGTSLSAGSGAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC84</accession>
    <name>A0A132PC84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Steroid C27-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33135</name>
        <name evidence="4" type="ORF">AWC31_17090</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858514.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17090"/>
    <dbReference type="EnsemblBacteria" id="KWX19940">
        <property type="protein sequence ID" value="KWX19940"/>
        <property type="gene ID" value="AFM11_33135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18106">
        <property type="protein sequence ID" value="ORX18106"/>
        <property type="gene ID" value="AWC31_17090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4959"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="416" mass="46271" checksum="7C84DB3838867BDC" modified="2016-06-08" version="1">MACPNIPKDFDFLDASLNLERLPVEELAELRKSEPIHWVDVPGGTGGFGDKGYWLVTKHADVKEVSKRNDIFGSSPDGAIPVWPQDMTRDAIDLQKAVLLNMDAPQHTRLRKIISRGFTPRAIGRLKDELDARAQNIAKEAAAAGTGDFVEQVSCELPLQAIAGLLGVPQDDRDKLFRWSNEMTAGEDPEYADIDPAMSSFELITYAMKMAEERAKNPTDDIVTQLIEADIEGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIGFSQHPDQWELYKKERPDTAADEIVRWATPVSAFQRTALEDTELGGVQIKKGQRVVMSYRSANFDEEVFENPHDFNILRNPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHMPDLKPIGQPERLKSGWLNGIKHWQVDYTGKCPVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCC9</accession>
    <name>A0A132PCC9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858315.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32205"/>
    <dbReference type="EnsemblBacteria" id="KWX19995">
        <property type="protein sequence ID" value="KWX19995"/>
        <property type="gene ID" value="AFM11_32830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4895"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009448">
        <property type="term" value="P:gamma-aminobutyric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004632">
        <property type="entry name" value="4NH2But_aminotransferase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00700">
        <property type="entry name" value="GABAtrnsam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="448" mass="46486" checksum="9577ADD7703D5F69" modified="2016-06-08" version="1">MTTTELAGQALTQERRLVTAIPGPLSQELQARKESAVARGVGTTLPVYVVAAGGGVLADVDGNQLIDFGSGIAVTTVGNSAPAVVDAVTQQVAAFTHTCFMVTPYEGYLRVAEQLNRLTPGDHDKRTVLFNSGAEAVENAVKIARAHTRRQAVVVFDHAYHGRTNLTMAMTAKNQPYKHGFGPFAGEVYRVPASYPLRDGDVDGAAAAARAIDLIDKQVGADNVAAVVIEPIHGEGGFIVPAPGFLRALQNWCTESGAVFVADEVQTGFARTGAMFACEHDGVVPDLIVTAKGIAGGLPLSAVTGRAEIMDAPHAGGLGGTYGGNPLACAAALAVIDTIERDGLVARAAQIGDTMLGRLNTLAATDARIGDVRGRGAMIAVELVKPGTTEPDADLTKRIAAAAHAQGLVVLTCGTYGNVLRFLPPLSMPDHLLAEGLDILDAVFQEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCF8</accession>
    <name>A0A132PCF8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_32940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858367.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32385"/>
    <dbReference type="EnsemblBacteria" id="KWX20013">
        <property type="protein sequence ID" value="KWX20013"/>
        <property type="gene ID" value="AFM11_32940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4918"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="218"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="390"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="470"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="576"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="728" mass="78012" checksum="0D09FC60DE95FECF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCL1</accession>
    <name>A0A132PCL1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32180"/>
    <dbReference type="EnsemblBacteria" id="KWX20034">
        <property type="protein sequence ID" value="KWX20034"/>
        <property type="gene ID" value="AFM11_32805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4890"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="98" mass="10406" checksum="9D64088E444858D6" modified="2016-06-08" version="1">MNPGGNARSTAPKASAAHVDDLKGIVRATLDIPLDTTVLVQQLACAEPGCPPVETVIAVLSSQRTTWKIPKPTADIAVTDLQRLITEHPEGHDHADHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCL2</accession>
    <name>A0A132PCL2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859198.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19722">
        <property type="protein sequence ID" value="KWX19722"/>
        <property type="gene ID" value="AFM11_34330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5208"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="179" mass="19818" checksum="7B1A0CB70B092BCD" modified="2016-06-08" version="1">MSLDKLESQLEGLRAQAASIQKRWARTRDNINNDNTLTDIGKKQKLDAEREQVSTKLSGLRKQETEAVAAQKQSLEKSLFGLGVVDSTYTDKIMSYRDAHDRAGRLELQSQGQELLASAMRSDDKILAAAVLAKALASEWRSVIAEYLKQNPRAGDDLNDLAKLQGYSPLEAGFSYVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCM8</accession>
    <name>A0A132PCM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858109.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19615"/>
    <dbReference type="EnsemblBacteria" id="KWX20079">
        <property type="protein sequence ID" value="KWX20079"/>
        <property type="gene ID" value="AFM11_32480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4824"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="328" mass="34005" checksum="0A9BC40066BEA392" modified="2016-06-08" version="1">MSTTKGRPTKADVARLANVSTATVSYVLNNVEGQRISEQTQAAVRNAAAQLGYRPNLAARNLAVGGSGVVLYIVGRLSLGNLPIEVGSRLTTALARHGIVLSLQFETDDDRNVVDAIADLNPVAVTSTFPLTGNALAAATAAGIPQIHLGSSQLHAIGALDRSIGEMRVEHLASRGHTRLAFAYTTDEELRPLGDYWLVGLRAAAQRRGLPEIGVASFAADGSNAAEIVSGWAADGVTAICAQSDETAFVVLHGLRRAGLRCPQDMAVMGVNAIELGAVSAPPLTSVSFDAKAIVDVAVAAMMSELGYPADQEPSSAGVATLIVRDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCS2</accession>
    <name>A0A132PCS2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Myo-inositol 2-dehydrogenase</fullName>
            <shortName evidence="1">MI 2-dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iolG</name>
        <name evidence="4" type="ORF">AFM11_31770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose</text>
            <dbReference type="Rhea" id="RHEA:16949"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17811"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.18" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857721.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32035"/>
    <dbReference type="EnsemblBacteria" id="KWX20130">
        <property type="protein sequence ID" value="KWX20130"/>
        <property type="gene ID" value="AFM11_31770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4681"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01671">
        <property type="entry name" value="IolG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023794">
        <property type="entry name" value="MI/DCI_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="137"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="339" mass="36124" checksum="DF8A1D3F650A1208" modified="2016-06-08" version="1">MSDLRVAVLGVGLMGADHVARITSRISGARVAVVNDYVAEKAEEIAAGVPGCRAIADPLDAIADADVDAVVLATPGSTHEKQLLACLEHGKPVMCEKPLTTDVETSLEVVRREAELGRRLIQVGFMRRFDDEYQHLKALLDSGGLGRPLVLHCTHRNPAVPHGFGSAMVVRDSLVHEVDVARFLLDEEIASIQIIKPAPNPSGPQGLADPQIAILRTVSGRHVDVELFVHTGVGYEVRTEVVGEKGSAMIGLDVGLVRRNAPGTWGGQITPGFRERFGRAYDTEIQRWVDAVRDGSNIDGPTAWDGYAAAAVCEAGVESLNSGEAVIVDLVARESIPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCX9</accession>
    <name>A0A132PCX9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_31935</name>
        <name evidence="5" type="ORF">AWC31_31960</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857802.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31960"/>
    <dbReference type="EnsemblBacteria" id="KWX20154">
        <property type="protein sequence ID" value="KWX20154"/>
        <property type="gene ID" value="AFM11_31935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12576">
        <property type="protein sequence ID" value="ORX12576"/>
        <property type="gene ID" value="AWC31_31960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4713"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX12576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="224" mass="24699" checksum="C07D14E0D16A8C59" modified="2016-06-08" version="1">MDEVLARAGIFQGVSPSAVAALAQQLEPVSFPRGKVIFVEGEPGDTLYIITSGKVKIGRKTVDGRESLLTLMGPSDMFGELAIFDPGPRTSTVTALTDVHAVTMSRSVLRSWIADRPEIAEQLLRVLARRLRRTNDNLSDLIFTDVPGRVAKQLLYLAQRFGSREGSSLRVDHELTQEEIAQLVGSSRETVNKALSDFAQRGWIRVQGKSILIDNTERLARRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCY9</accession>
    <name>A0A132PCY9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857912.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20190">
        <property type="protein sequence ID" value="KWX20190"/>
        <property type="gene ID" value="AFM11_32140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4755"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="140" mass="15551" checksum="C7FF7D10B6B37FA2" modified="2016-06-08" version="1">MTSPATRQAKQARGDLFDPDCPTRRLLDRIGTKWTSMVIKVLADAGDGEVRFADLRRRTPGVSQKMLSVTLQSLTRDGLIARRVEPTVPPKVHYRLTDLGRSLNVPLTALRDWAEAHMVEIDRANAVQSAESTRGANRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD15</accession>
    <name>A0A132PD15_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidinol-phosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_31240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857408.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25390"/>
    <dbReference type="EnsemblBacteria" id="KWX20219">
        <property type="protein sequence ID" value="KWX20219"/>
        <property type="gene ID" value="AFM11_31240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4153"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011809">
        <property type="entry name" value="His_9_proposed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02067">
        <property type="entry name" value="his_9_HisN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX20219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="260" mass="27609" checksum="60998AAD7D840DCA" modified="2016-06-08" version="1">MTTVADDMTLALALADQADALTMDRFGAMDLHVETKPDLTPVTDADRGAEEALREALAAARPDDTVFGEEFGGTTTFSGRQWVIDPIDGTKNFVRGVPVWCTLIALIADGVPVVGVVSAPALARRWWAGHGEGAFGSFGGVTRKLAVSGVKELESASLSYSDLTTGWEGRRQRFVDLTDAVWRVRAYGDFWSYCLVAEGAVDIACEPEVKLWDIAPLDILIREAGGTFTSIDGQAGPHGGSALATNGLLHGAVLNRLSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD34</accession>
    <name>A0A132PD34_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_31275</name>
        <name evidence="15" type="ORF">AWC31_25425</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857429.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25425"/>
    <dbReference type="EnsemblBacteria" id="KWX20226">
        <property type="protein sequence ID" value="KWX20226"/>
        <property type="gene ID" value="AFM11_31275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14536">
        <property type="protein sequence ID" value="ORX14536"/>
        <property type="gene ID" value="AWC31_25425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4160"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="13">
        <location>
            <begin position="56"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="12">
        <location>
            <begin position="200"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX20226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX14536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="297" mass="32823" checksum="7D863B30D1175983" modified="2016-06-08" version="1">MRFGFLVNEVLTGLRRNVTMTVAMILTTAISIGLFGGGLLVVRLADQSRDIYLDRVESQVFLTDDISANDATCDSDACKALYREIDDRDDVRSLRFLNREQAYDDAIKKFPQYKDVAGKDAFPASFIVKLNDPEQHEAFDKAMVGQPGVLNVLNQKDLIDRLFAVLDGLSSAAFAVALVQAIGAVLLIANMVQVAAYTRRTEIGIMRLVGATRWYTQLPFLVEAMLAALIGVVIAVVGLIVVRAVFLEKALDQFYQANLIARIDYADILYISPILLFVGVAMAGVTAYVTLRLYVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD49</accession>
    <name>A0A132PD49_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_31520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857548.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26100"/>
    <dbReference type="EnsemblBacteria" id="KWX20265">
        <property type="protein sequence ID" value="KWX20265"/>
        <property type="gene ID" value="AFM11_31520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4209"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017794">
        <property type="entry name" value="Urea_CO2ase-assoc_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03428">
        <property type="entry name" value="ureacarb_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="514" mass="54390" checksum="EDD0A1737D652B1D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD86</accession>
    <name>A0A132PD86_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858490.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17130"/>
    <dbReference type="EnsemblBacteria" id="KWX19932">
        <property type="protein sequence ID" value="KWX19932"/>
        <property type="gene ID" value="AFM11_33095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4951"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="281" mass="31436" checksum="56843FD28B1DE26B" modified="2016-06-08" version="1">MGEPFVGSAAVARGEVLKSALRTRYTRAFRDVYVSPGTELTPEVRARAGWLWSRRRGIIAGRSAAALYGAKWVSPGEPLEMLHSNRNPMAGLKVRTERIEHDEITLHSGIPVTTLARTALDMGCWYPRDLAVESLDALAASTDLKPADVDLLLQRYAGRQGVQRARVALELMDAGAQSPKETQLRLMILDDGMPRPATQIPVIDGPGDPFAFLDMGWDDLMVSVEYDGEQHRLNDSQYRWDLRRAERVQRAGWLNVRVSAGERRVDILRRIHAARASRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDI2</accession>
    <name>A0A132PDI2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_31000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857235.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26710"/>
    <dbReference type="EnsemblBacteria" id="KWX20380">
        <property type="protein sequence ID" value="KWX20380"/>
        <property type="gene ID" value="AFM11_31000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4102"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="249"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="464" mass="48716" checksum="A9C462CA7EFB0B17" modified="2016-06-08" version="1">MTVSTASTTAPFFSRERIIAPPGWSRWLVPPAALSIHLSVGAAYSWSVFKKPLEGALDISGTLSALPFTIGIVMLGLSAAVFGTWVDRNGPRMAMFAAMCCFCGGWLVGAAGLALGQYWLVLLGYGVLGGIGWGIGYISPVSTLIKWFPDKPGMATGLAIMGFGGGALIASPWSTAMLGAFGTDTAGIAKTFVVHGLAYAVFMSLGWLLVRVPRPDWRPTGWTPPPVQAGSIVTGGQVSAGNAVKTPQFWLLWVVLCFNVTAGIGILEKASPIYQDYFPMAGAAAGALAAAAAGYVAMLSLGNMLGRIGWSSLSDVIGRKNAYRLYLGVGALLYLTITVMENSNKLIFLIATILILSFYGAGFATVPAYLRDLFGTFQVGAIHGRLLTAWSAAGILGPIIVNSVADSQAASGKDGPALYTVSFSIMIGLLVIALVCNELIRPVSSKWHEPENNPTKPVAKEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDM6</accession>
    <name>A0A132PDM6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856740.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20433">
        <property type="protein sequence ID" value="KWX20433"/>
        <property type="gene ID" value="AFM11_30055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3904"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="90" mass="9865" checksum="B55B21D9F5D29C84" modified="2016-06-08" version="1">MATGTKAHLEEAESCLRSAQSETDTSRRTQFAQAAMDSAAEVAWDTGASVEDRSNARAIMRTSLKLRVETVHSRRIGRGRSADGREIQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDU7</accession>
    <name>A0A132PDU7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857764.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20142">
        <property type="protein sequence ID" value="KWX20142"/>
        <property type="gene ID" value="AFM11_31860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4698"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="382" mass="40407" checksum="0D7FDA083EEB823A" modified="2016-06-08" version="1">MGWRKAAITGVGVSRQGKYPDETPNSLAAEAFVAALDDAGLRREDIDGLLTMPGTKSPEGAKHYLALGELLGINPVLTGSLSMGGATAGALIQQAALAIEAGMATTVACVFGDTAKTGGSRFNADAGTEGDSWGIWGMFGNAANSAFGAQRHMALHGTTSEQLGWIAVTTRKHASMNPAAIMRKPITIDDHQDSRMIVDPLHMLDCCIISDGAVAIIVTSAERARDNASTPVDVWGMGQGHTLVKLGTPDWWYLPHQADCISRAYRMAGVSPEEIDVAQLYDNFTISVLFWLEHAGFCKPGEAGPFVEGGTRITFGGELPVNTAGGNLSESYMQGWLHVVEGVRQIRGECGERQVDDAQLCLVTGRGMTLNTASCLILGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE03</accession>
    <name>A0A132PE03_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29650</name>
        <name evidence="2" type="ORF">AWC31_24990</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856487.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20569">
        <property type="protein sequence ID" value="KWX20569"/>
        <property type="gene ID" value="AFM11_29650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14460">
        <property type="protein sequence ID" value="ORX14460"/>
        <property type="gene ID" value="AWC31_24990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3822"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX14460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="243" mass="27031" checksum="920F131E27AAE7FF" modified="2016-06-08" version="1">MIDDTLAHRLAEQASQPLEPIYALLGRIAEVVLRSRPPRAALTEGHFSGLQRMLAELLQDERGVWGMGFIAAPFVVEGRERYLAWWQRRDDRVARLRLNFDPTSVDVYDYLQMDWYQLALRGQARVAYGPYVDYSGSDMYTITATIPIVADDGTFLGVAGADLVVGDVERKLLEVLRQTSEDAVVISTERRVIAANTPRWIVGSRLPAMPTAGPAGDSSAFREVAEMPLGIGWVLAIAWPEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEG7</accession>
    <name>A0A132PEG7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040122.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20684">
        <property type="protein sequence ID" value="KWX20684"/>
        <property type="gene ID" value="AFM11_29090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3700"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="108" mass="11718" checksum="DB25B312785028B8" modified="2016-06-08" version="1">MIAEIRLLTNSIEISERFWRAIYPTADAERGADRWGRQSVRITPQTGPDLLIGEAAAWNLITTVDMVVQTDAGAAQRLRDAGFEVAHDGTQAVDVNATDATVVLVAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEJ4</accession>
    <name>A0A132PEJ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_31145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857308.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26855"/>
    <dbReference type="EnsemblBacteria" id="KWX20402">
        <property type="protein sequence ID" value="KWX20402"/>
        <property type="gene ID" value="AFM11_31145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4133"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="104" mass="11176" checksum="280E91B67DBE52C8" modified="2016-06-08" version="1">MRTFEQTLPAQRTALSWTRTSFAVLGTGAVHMLHDIQDHRAGFGLVAAGVAVVISLLTYLVGVRRQRLLARDPLPKRLAATVEVHAVTAAVLILIAVSVLSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEL0</accession>
    <name>A0A132PEL0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20765">
        <property type="protein sequence ID" value="KWX20765"/>
        <property type="gene ID" value="AFM11_28370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3548"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="122" mass="13698" checksum="2419C4645A3B0EAB" modified="2016-06-08" version="1">MSDSPSAEFLAGLPADTRPIAERLISTIAGHAPFDVAVKWRQLTFAVDGDFDHWVCAVAATKRQVHLAFHFGSLLREPEVGFEPSESKYVRKLRYRSVEDVDEAVVRELVTQALEELPRFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEN2</accession>
    <name>A0A132PEN2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_28620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20798">
        <property type="protein sequence ID" value="KWX20798"/>
        <property type="gene ID" value="AFM11_28620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3604"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="446" mass="47266" checksum="6A075E4E456F923B" modified="2016-06-08" version="1">MEYQLGIPNEGGLMSNTRWRMFALLLLLVTVNYVDRGSLSVALPAIKEDFHISAEVTGVLLSAFFWAYAAMQIPAGWLIDRFGPRKLITVACTGWGAATAVSGMAPNIGTMAIARGAIGITEAPIMPAGGKLNAAFLTEKERGRGATILDAGAPLGSAVGGIAIAGLIAVTGSWRWAFIVAGVVTMLLGIWAWRAIRDTPEEHPKVNAAEREYLMTAHREENARHQSTGKRAGLVHYMKYRSFWAMCLGWLGFNGVFYGLLTWGPLFLSESKGFNLNAIGWSTFVIFGSGFVGEIIGGQLADRLKEKGYDTNRVMRSLLGFAGTCVVAGLVGVVLMPGPIAAILLLSTVLFFLRWVGLFWSVPAILGGREDAGVLGGAMNLAGNVSGFVTPMAVGFIVGATGGYTWALLYFVGAGVVMTAAVLVLDYAKRLAPKAAPVPAENGATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEN8</accession>
    <name>A0A132PEN8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_28605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856186.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20795">
        <property type="protein sequence ID" value="KWX20795"/>
        <property type="gene ID" value="AFM11_28605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3601"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="228" mass="25110" checksum="FB7CC330BA46E275" modified="2016-06-08" version="1">MPSTPSDDSPPSNLLLRGRLLDALRTDVIKGRYPPGYRLVERDVADAYGVSRLPAREALQALRTEGFLEVRKTRGLVVRGWTERDVTELFDIRQALEAMACREAAENRTDDDIAALRGAADDADTAAERGDSSAAHDANALFHQLLVTASHNRTLGEIMAPILYRVQWLVRQIPDPHTVSADHHHLVDAIAEGDAPAAERLAIDHAERNRATTLQTLFADAPRRSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEX4</accession>
    <name>A0A132PEX4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27725</name>
        <name evidence="3" type="ORF">AWC31_10260</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10260"/>
    <dbReference type="EnsemblBacteria" id="KWX20886">
        <property type="protein sequence ID" value="KWX20886"/>
        <property type="gene ID" value="AFM11_27725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08885">
        <property type="protein sequence ID" value="ORX08885"/>
        <property type="gene ID" value="AWC31_10260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3419"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016676">
        <property type="entry name" value="P_lipid/glycerol_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016753">
        <property type="entry name" value="P_lipid/glycerol_ac_tran_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="56"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX08885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="274" mass="29925" checksum="34C2181D6A7ED7C4" modified="2016-06-08" version="1">MGCAPNEGRAPVGTPERAKWDPTFVRQVTAWLRPMARCWFRPEVRGIDRIPADGPALVVSNHSGGMMTPDVLIYAPVFYDRFGYDRPLHTLAHYGVLMGPLSWVMNRLGVIEASPENAAAALGAGAVVLVFPGGDYDSYRPTFEANTIDFNGRTGYVRTAIEAGVPIVPAVSIGAQETQLFLSRGHRLARRLGLKRIRMEILPVSVGLPFGLTVLLPPNLPLPAKIVAEVLEPIDIESQFGSSPDIDEVDRHVRAVMQDALDRLSAERRLPVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFB4</accession>
    <name>A0A132PFB4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855213.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06755"/>
    <dbReference type="EnsemblBacteria" id="KWX21020">
        <property type="protein sequence ID" value="KWX21020"/>
        <property type="gene ID" value="AFM11_26905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3255"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="28351" checksum="A62573B15CECAF4E" modified="2016-06-08" version="1">MGALDVLDDWPVPTAAAAVVGPSGVLATHGDSGKPFALASVTKPLVARAAQIAIEEGVVELDTPAGPPGSTVRHLLAHASGVSMNSADVIAQVGQRRVYSNYGFELLARAIEDAADIEFGRYLTEAVFEPLGMAASKLLGGAEVAGFGGVSTVADLAAFASELLRPALVSPAMHADAVSVQFPGLAGVLPGFGAQRPNDWGLGFELRDSKSPHWTGSANSPATFGHFGQSGTFLWVDPAADVALIALTDRDFGDWTYELWPAISDGVLREIGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFC2</accession>
    <name>A0A132PFC2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855192.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06715"/>
    <dbReference type="EnsemblBacteria" id="KWX21013">
        <property type="protein sequence ID" value="KWX21013"/>
        <property type="gene ID" value="AFM11_26865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3246"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="215"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="320" mass="34272" checksum="B4271B0A57036CA9" modified="2016-06-08" version="1">MHTVAVLALPDVNTFDLSTAVETFGRARLTSGEPAYRVLVCSDEPVVAAGPVRIGTDHGLCRLAEADTVVVPGCNDAATTPSDEILAALRDAHAAGIRVASICTGAFVLAAAGLLDGKRATTHWLAADVFRDAFPEVTLDPDVLYVDEGQVLTSAGASAGIDLCLHMIGRDHGAAVAADAARLAVAPLHRAGGQAQFIRRNSLAARQIGERTELDDVLTWIEQEAHRELTLADIAVRAAVSVRTLNRRFQAETGQTPMQWLAGVRIRHAQQLLECTSDGIEHVGRQVGFTSAANFREQFRKLTGVTPQHYRNTFRDRVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFN0</accession>
    <name>A0A132PFN0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_26890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855204.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06740"/>
    <dbReference type="EnsemblBacteria" id="KWX21017">
        <property type="protein sequence ID" value="KWX21017"/>
        <property type="gene ID" value="AFM11_26890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3251"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017816">
        <property type="entry name" value="MycoS_dep_FDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03451">
        <property type="entry name" value="mycoS_dep_FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="7"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="362" mass="38169" checksum="4884CF66694B3F15" modified="2016-06-08" version="1">MPQTVRGVISRSKKQPVELVDIVIPDPGPGEVVVDIIACGVCHTDLTYREGGINDEYPFLLGHEAAGTVEAVGAGVTHVEPGDFVVLNWRAVCGECRACKRGRPHLCFDTHNAAQKMTLTDGTELTPALGIGAFADKTLVHEGQCTKVDAEADPAVAGLLGCGVMAGIGAAINTGAVGRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDNKKLDWARDFGATHTINARDLDPVVTIQDLTDGFGADVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMTLEMPLVDFFSRGGALKSSWYGDCLPERDFPTLISLYLQGRLPLEKFVSERIGLDAIEDAFHKMHAGEVLRSVVVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG37</accession>
    <name>A0A132PG37_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854392.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24765"/>
    <dbReference type="EnsemblBacteria" id="KWX21290">
        <property type="protein sequence ID" value="KWX21290"/>
        <property type="gene ID" value="AFM11_25515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2966"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="158" mass="16710" checksum="A1599368E89B6B54" modified="2016-06-08" version="1">MKLPVATEWALHCATSLAQLEAGATASAADLAEYFDLPAAYLAKQLQALTRAGVLAATTGPRGGFRLGRAASDITLLQIVEAVDGASAPYDCREIRKQGRGALPASWCRHTCILAVKMADAHQAWRASLDGVTLADILADLPATAPARTRSLLTRDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG50</accession>
    <name>A0A132PG50_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854434.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24680"/>
    <dbReference type="EnsemblBacteria" id="KWX21305">
        <property type="protein sequence ID" value="KWX21305"/>
        <property type="gene ID" value="AFM11_25600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2983"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="27758" checksum="CEC7BA00CC8451DD" modified="2016-06-08" version="1">MSADVLHIHRFGPPGSPQVLLVHGLTGHGRRWKTLATRHLAEFSIVAPDLIGHGQSSWAAPWTLDANVAALSGLLDGPTLVVGHSFGGAVALNLAAAHPDLVSGLVLLDPAVELDGEWMRDIADNMMASPDYPDRGEARDEKVNGSWGEVEPAELERELDEHLVELPGGRWGWRISIPAMMAYWNELARPVALPRKGTPTALVRATRTDPPYAREALIDGLAAHLGADFTLLDWDCDHMVPVAKPADTAALIRERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG55</accession>
    <name>A0A132PG55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protocatechuate 3,4-dioxygenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Protocatechuate 3,4-dioxygenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_25725</name>
        <name evidence="6" type="ORF">AWC31_36170</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854497.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36170"/>
    <dbReference type="EnsemblBacteria" id="KWX21326">
        <property type="protein sequence ID" value="KWX21326"/>
        <property type="gene ID" value="AFM11_25725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12049">
        <property type="protein sequence ID" value="ORX12049"/>
        <property type="gene ID" value="AWC31_36170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3009"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018578">
        <property type="term" value="F:protocatechuate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024756">
        <property type="entry name" value="PCDO_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012785">
        <property type="entry name" value="Protocat_dOase_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12391">
        <property type="entry name" value="PCDO_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02422">
        <property type="entry name" value="protocat_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="4">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX12049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="259" mass="29504" checksum="415B67B3DFA5BDAC" modified="2016-06-08" version="1">MTAPIDTNPDSASASQAEINAEIAAIETGYLQTGIEETQPRLDYAPYRSSLLRHPTKDLHHADPETIETWAPVFGARDVHPLEADLTIQHDGEPIGERMVVTGRIVDGEGRPVRRQLVEIWQANSAGRYIHKRDQHHAPIDPNFTGVGRCLTDDDGTYRFTTIKPGPYPWKNHRNAWRPAHIHFSLFGTDFTQRMITQMYFPGDPLFALDPIYQSITDQKARDRLVAAYDHDVTTHEWATGYRWDIVLTGAHRTHFEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG96</accession>
    <name>A0A132PG96_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_25535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854403.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24745"/>
    <dbReference type="EnsemblBacteria" id="KWX21294">
        <property type="protein sequence ID" value="KWX21294"/>
        <property type="gene ID" value="AFM11_25535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2970"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="259" mass="27568" checksum="D8C230019F92D5B0" modified="2016-06-08" version="1">MSDLEYTVADGVGTILLNRPHRKNAFTLDMLDRWAEALRSARTDPDVRVVLVTGAGGAFCSGVDLDDFAEITTTLGRQQVLQDRVHRVAAAALDLDKPLIAAVDGVAVGAGMDMALACDLRLASTRARFSEGYVRVGLIPGDGGAHLLPRIVGQARALELLWTGRFVEADEALSLGLVLSLHSPADFPAAVGDLCRRLAAGPPVAIRAIKRLVRNGERVDFLTSLSMVAAEQAVVQSTADSAEAVAAFREKRKPVFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGE6</accession>
    <name>A0A132PGE6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_25480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854383.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24800"/>
    <dbReference type="EnsemblBacteria" id="KWX21287">
        <property type="protein sequence ID" value="KWX21287"/>
        <property type="gene ID" value="AFM11_25480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2958"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453253" evidence="5">
        <location>
            <begin position="22"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="68"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="262" mass="28097" checksum="3D779A3CBDB6F8A8" modified="2016-06-08" version="1">MTTSALPVQFRRRVKAHTSSAIAVLAAVATLVAGWQVAVVVGNRVPSPGDTLDRLAAEQAAGQLWHQLAISTNRFLLGLALALVVGAALGVLMGLSRLADLAFSDLTMAGLAIPAVIWALLTTMWFGFGWLTPVTTVFLSGLPFVIVNIAKATRAVPADLVLMARAFGVPRVQVLRQIVAPAVAGSSVAAVRFAIMSAWNGLLLAEWFGSTSGVGWRSRYWYDANQLDGFFAWVLVFVLLLVIADQLILGPLERYVTRWRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGF7</accession>
    <name>A0A132PGF7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25550</name>
        <name evidence="4" type="ORF">AWC31_24730</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854412.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24730"/>
    <dbReference type="EnsemblBacteria" id="KWX21297">
        <property type="protein sequence ID" value="KWX21297"/>
        <property type="gene ID" value="AFM11_25550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14417">
        <property type="protein sequence ID" value="ORX14417"/>
        <property type="gene ID" value="AWC31_24730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2973"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="1">
        <location>
            <begin position="132"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX14417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="380" mass="41255" checksum="1C5DC9FF8368BFB2" modified="2016-06-08" version="1">MNMTRLVPPVAGDPHDLDELRLEVRQFVTEQQRSGKIGRYADSWLTGWDEDFSRALAARGWLGMTVPIEYGGHGRSHQERFVVTEELLAAGAPVGAHWIADRQIVPSLLKYGTEVQKRKFLPAIAKGECYFGIGMSEPDSGSDLASVRTKAVQTDGGWQLTGTKVWTSGAHLAHAFICLARTAPVDPAHRHDGLSQFIVDLRAPGVDIRPIISMNGKHHFNEVILDDTFVPDDMVFGTIGNGWQQVTSELSFERSGPERFLSTFPLLADVAGHMADGTLARHTDLGRYVARIAGLHQMSIAVAGALERHEPADTAAAVVKVLGTSTEGDIADFADLLGETDDDAYNVMLADAVVQRPGFTLRGGTNEILRGVIARGLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGU6</accession>
    <name>A0A132PGU6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_25335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854265.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27655"/>
    <dbReference type="EnsemblBacteria" id="KWX21533">
        <property type="protein sequence ID" value="KWX21533"/>
        <property type="gene ID" value="AFM11_25335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2429"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="283" mass="30719" checksum="EC95C6A2DA46D881" modified="2016-06-08" version="1">MTTSYVAQDDLPTETMSPNNGPAQPVRRKRKVSNFALSGISTVVLIVAFLVFAEIGARAGLWSDRVLPAPSVILAELGRLLGRPQFWDDAARTGIEVAFSIVFGSLFGFAAGLIFWKLPAVGRIFEPYLVSFYAVPLVLFYPVMIVLVGINAMSVIILATIMAAIPMALNTAVGLNSMPPVYMKLARSLKASPRQTLFAIAIPAAGPFIVAGLRLAVVYALVGTIAMEFTTAQAGLGYRIRYLYEIFNNNEMFAYIAVVLVLSCILTVLLALVERVLLRGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH03</accession>
    <name>A0A132PH03_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854303.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27720"/>
    <dbReference type="EnsemblBacteria" id="KWX21544">
        <property type="protein sequence ID" value="KWX21544"/>
        <property type="gene ID" value="AFM11_25400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2442"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="210"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="502" mass="52957" checksum="C835F2333B123319" modified="2016-06-08" version="1">MGLGRAYSVAVRGLDGVIVEIEADITSGLPGVHLVGLPDAALQESRDRVRAAITNCGNSWPMSRLTLALSPATLRKVGSVYDLALASSVLSAHTKTAWPRLEKTVLLGELALDGRVRPVNGVLPAVLAAKHEGWPSVVVPADNLAEASLVDGIEVLGVHSLGQLKAWFEGKAELPGRVAAPGRAPEPTADLADVVGQGQARFAVEVAAAGAHHLMLTGPPGIGKTMLAQRLPGLLPPLSYAESLEVTAVHSVAGLLSDDTPLITRPPFVAPHHTCSVAALVGGGSGMARPGAVSQAHRGVLFLDEFAEIGVSSLEALRTPLEDGEIRLARRDGVACYPARFQLVLAANPCPCAPPNPVDCICSSQARRRYMGKLSGPLVDRVDLRVELHPMSAGAFAPDAGESSATVRERVAFARLAAEERWRPYGIRTNAEVSGPLLRRKFRLPKATMEPLRTALERGVISIRGADRCLRVSWTLADLAGRSMPALEDVTAALSFRQAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH87</accession>
    <name>A0A132PH87_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854601.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35950"/>
    <dbReference type="EnsemblBacteria" id="KWX21362">
        <property type="protein sequence ID" value="KWX21362"/>
        <property type="gene ID" value="AFM11_25950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3055"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045596">
        <property type="entry name" value="DUF6459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20060">
        <property type="entry name" value="DUF6459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="168" mass="18401" checksum="8A4F2AC34D7E138D" modified="2016-06-08" version="1">MTTPEATSGPTTELPSLTSPVIDCEPPALPLHAQAPPTPVCSAPTALRRHTARRLRLVEPPQERQPHAGAVEFADLALRRVLEVVDRRRPPAQLRTLMNPLLLDAVVALTRSRQGTAATLRRVRLRAVTDPAAAEVFATYTRGTRVRAIAGRIEFHSGRWQFTALQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHD0</accession>
    <name>A0A132PHD0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fuculose phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853590.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24025"/>
    <dbReference type="EnsemblBacteria" id="KWX21617">
        <property type="protein sequence ID" value="KWX21617"/>
        <property type="gene ID" value="AFM11_24105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2180"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="219" mass="22846" checksum="D1BA9B9E9E9548CF" modified="2016-06-08" version="1">MSAPTQLAAERQQVVEACQFLSRSGLVVGTAGNVSIRVGDLVVISPSGVDYEAMSARDVGIHDLDGNAVDAALAPSSELALHLAVYHTTEHTAVVHTHGPASTALSTVVDEVPASHYYSALFGGAVRVAPYATFGTQALADNVTTALRDRTAALMGNHGAVLVGRALPKVLNLVPYLEYICDVQLRAMASGAPVRVLDDDEIAEVGRRLAGYGQQATRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHH3</accession>
    <name>A0A132PHH3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_23400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28125"/>
    <dbReference type="EnsemblBacteria" id="KWX21799">
        <property type="protein sequence ID" value="KWX21799"/>
        <property type="gene ID" value="AFM11_23400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2035"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="753"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="841"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="757"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="988"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1037" mass="109884" checksum="5D7F24EBBBEF58A3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHJ8</accession>
    <name>A0A132PHJ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854129.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21482">
        <property type="protein sequence ID" value="KWX21482"/>
        <property type="gene ID" value="AFM11_25050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2371"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453038" evidence="1">
        <location>
            <begin position="32"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="88"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="235" mass="25437" checksum="DA4B1CA65326CDCD" modified="2016-06-08" version="1">MTRRRVGWLAAAVALAVVVAIQVMVSDQRSARFVAQAQTPTVAAGIDPLAGLAEIPIRVRGNDYRRAAFGEAWDDENSAPGGRNGCDTRNDILNRDLADKTFVSIKRCPNAVATGTLHDPYTNVVVAFVRGNQTGAAVQIDHIVPLALAWDLGARDWPDELRLRFANDPANLIAVAGEANQNKGDQEPAHWMPPNRAFWCQYAVQFVEVLRGYRLPVDAPSAVVLREAAGTCPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI42</accession>
    <name>A0A132PI42_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853343.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21857">
        <property type="protein sequence ID" value="KWX21857"/>
        <property type="gene ID" value="AFM11_23725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2102"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="167" mass="17882" checksum="EC3C70E526F42DA5" modified="2016-06-08" version="1">MTHDGMTHDGGPALPPPVWPADDAAPAGLREPGTPLTRLAARLAPGRYDRQLLAGTAPEPGSALAVHVARSTSDGQRRQIALILRVVLRELHRDPTLYSSRVPLDDGTVGSAVTLIDEIRERLEASRPVRAHGIARLRMLLSNGAGPFYRQGAGDLRADLRAVLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI74</accession>
    <name>A0A132PI74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_24655</name>
        <name evidence="5" type="ORF">AWC31_23465</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853851.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21702">
        <property type="protein sequence ID" value="KWX21702"/>
        <property type="gene ID" value="AFM11_24655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15531">
        <property type="protein sequence ID" value="ORX15531"/>
        <property type="gene ID" value="AWC31_23465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2292"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX15531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="219" mass="23655" checksum="CEA28B17043F0EBB" modified="2016-06-08" version="1">MASLNDDRVAGVLDRLYTAASEQHARFRADGPGRFARLENASVQERADALSDIYMPVTREAGRLLYSLVRAARPQIVVEFGMSFGLSALHLASAVRDNGTGRVFTTELSAAKIAAARATFAEAGLDDVITVLEGDALETLQTVAGDIGFVLLDGWKELYLPVLKILEPQLVPGALLVADNTSMADTQPYLDYVRDPANGYVSVNFLARDSDSMEITSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI84</accession>
    <name>A0A132PI84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_24010</name>
        <name evidence="5" type="ORF">AWC31_24145</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853875.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24145"/>
    <dbReference type="EnsemblBacteria" id="KWX21712">
        <property type="protein sequence ID" value="KWX21712"/>
        <property type="gene ID" value="AFM11_24010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15737">
        <property type="protein sequence ID" value="ORX15737"/>
        <property type="gene ID" value="AWC31_24145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2161"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZnF_CDGSH" evidence="3">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX15737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="60" mass="6638" checksum="3FC5724BF16A64B6" modified="2016-06-08" version="1">MVQGPVRIELPDGSVVDSDRFMVAICACRRSKNYPLCDTSHRRRCRVNDTGPTGSAQRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIC7</accession>
    <name>A0A132PIC7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852367.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22096">
        <property type="protein sequence ID" value="KWX22096"/>
        <property type="gene ID" value="AFM11_21565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1661"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="360" mass="38522" checksum="E2DCD2C4B5749781" modified="2016-06-08" version="1">MRSAEDAAVVPVTARTEYLTGRHRIAAITAATALAAGLVALVALNYAGAPDAFTAAVVAALVTVTFGAVAYRRVEKPGAVLITVDGHTVQVGDEHRGIVGYPLSSLIAVGRAGPADETTPEARRLTVRGHKYVKLTFATDTGTDEWWVAVAAWDPAAAEVLRRLEEALPDAQPEAGPAVSGARIADAGTDEAAKRLWEEASRRHHDILGAYGRYELDAGMLLRYPAITDVTVEQTQTFHVALDEAAALRTDAYPGNRGLADAYQQAVVTLRRAWIACETHGKKVGTAYLDPADRTELDTALKLYNHAASSNTPAEQATYYGRVREIVTRLTDRGVLHPPKGQLAQLEGVTRRAIEAARSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIE7</accession>
    <name>A0A132PIE7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_21700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852405.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04505"/>
    <dbReference type="EnsemblBacteria" id="KWX22115">
        <property type="protein sequence ID" value="KWX22115"/>
        <property type="gene ID" value="AFM11_21700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1688"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="4"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="455" mass="48456" checksum="5CFB6108AC8A812D" modified="2016-06-08" version="1">MTASQVINPATEEVLASVELLDESAVDDAVARARAAQRKWAAQAPAERAAALRAFAAAVDSHIDELAALEVANSGHPIGQAEWEAGHVRDVLNFYSATPERLSGKQIPVAGGLDVTFNEPLGVVGVITPWNFPMTIAAWGFAPALAAGNAVVLKPAEWTPLTTIRLGEIAAESGLPADLFQVLPGRGSVVGERFVSHPDIRKVVFTGSTEVGMRVMAGAAKHIKRVTLELGGKSANIVFDDCDLEKAAATAPYGVFDNAGQDCCSRSRILVQRNVYDRFMELLEPAVKGVVVGDPAVRDTEMGPLVSRPHWESVSSYVPEDAPVAFRGSAPEGPGFWFPPTVLTPQRTDRTVTDEIFGPVVTVLPFEDEADAIALANDTPYGLSGSIWTDNLSRALRVSRAVESGNLSVNSHSSVRYNTPFGGFKQSGLGRELGPDAPLSFTETKNVFIAVEDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJD9</accession>
    <name>A0A132PJD9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852142.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22307">
        <property type="protein sequence ID" value="KWX22307"/>
        <property type="gene ID" value="AFM11_20965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1534"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="126" mass="13056" checksum="EC0C92E227FFF487" modified="2016-06-08" version="1">MIRFLLRIAIFLGSSAIGLLVAAWLVPGVRVSALGFIAAVVIFTVAQGILSPFFLKMANRYASAFLGGIALVSTLAALILASVLTTGLSIRGIGSWVAATVVVWLVTAVATLVLPMLVLKKKSAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJG9</accession>
    <name>A0A132PJG9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851895.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28445"/>
    <dbReference type="EnsemblBacteria" id="KWX22453">
        <property type="protein sequence ID" value="KWX22453"/>
        <property type="gene ID" value="AFM11_20070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1350"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="115" mass="13069" checksum="1C50B2AF1CBC810C" modified="2016-06-08" version="1">MHAFDVLGDPVRRRILELLADGELTAGAIGAEVQAEFGISQPAVSQHLKVLRDNGFTNVRAEGQRRLYSVDSAPLRDIDQWLDTFRRFWTPHLDALATEIARGKRQRRIEGKHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJH6</accession>
    <name>A0A132PJH6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851941.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22498">
        <property type="protein sequence ID" value="KWX22498"/>
        <property type="gene ID" value="AFM11_20325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1398"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="217"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="557" mass="59888" checksum="E6D5EE1E2C526F35" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJK3</accession>
    <name>A0A132PJK3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5709 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851974.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22529">
        <property type="protein sequence ID" value="KWX22529"/>
        <property type="gene ID" value="AFM11_20525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1442"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043763">
        <property type="entry name" value="DUF5709"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18970">
        <property type="entry name" value="DUF5709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5709" evidence="2">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="164" mass="17296" checksum="0C6F0DDE657CB4C1" modified="2016-06-08" version="1">MNSPSFGTGPAAGEDSIDDENQLQPQDTLIDRGVDDVLDEGYSPPERPYGPGAFGPAESLDQLLAEEEFDPVARVGDPLDVVDRRRSDDAERQAEFPERGEVGRVRAGRLVAPDQGFGEDVESELVADDAGLSGGAASAEEAAVHVIDDDSGPGTYAQAPGDQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJK5</accession>
    <name>A0A132PJK5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851965.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22520">
        <property type="protein sequence ID" value="KWX22520"/>
        <property type="gene ID" value="AFM11_20470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1428"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="143" mass="16073" checksum="4AB61CD724C4F95D" modified="2016-06-08" version="1">MSNDTLTPLREVVRKFNKHVLNPAMMHLAGRRYWYASVIRHTGRASGKQYATPVVAEQVAGGFLVPLPYGTRVDWLRNVLASGQATIVTKGQTHQVAVPKIIDLAEASAQLTPSRRRAFERFRIEKFLKLVSVQRVSGDHNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJK8</accession>
    <name>A0A132PJK8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851973.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22528">
        <property type="protein sequence ID" value="KWX22528"/>
        <property type="gene ID" value="AFM11_20520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1441"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="141" mass="15453" checksum="D957133936B4A9B2" modified="2016-06-08" version="1">MSTTTKVPALDHAMHTAHTWVNAVARQFGTEDHEFAYGVLRAWLHTLRDRLTVAAAAHFAAQLPDLVRGVFYAGWDPDAVPVKFDADAYGVRFAHEANISVHDVDKAATAVTAALVGFLPAAQIEKVLEQLPRDVRARLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKE4</accession>
    <name>A0A132PKE4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine transporter LysE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_17630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851103.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22773">
        <property type="protein sequence ID" value="KWX22773"/>
        <property type="gene ID" value="AFM11_17630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.881"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="213" mass="21968" checksum="C2770EEE8C1CF0FF" modified="2016-06-08" version="1">MVSADRLLAFAAMSFVLIVVPGPSVLFVIGRALAHGRQTALTTVAGNALGAYMLVVAVAFGVGTVVEHSVVAFTALKLAGAAYLIYLGVTAIRHRGELQANLDGGDPRHGVSRTLWDGFAVGVANPKTIVFFAAVLPQFVDRGNGHGVIVQILILGLVFNLIAIASDSVWGLVAATARSWFAHSPRRLAMVGGVGGLAMIGLGVTVAATGRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKQ7</accession>
    <name>A0A132PKQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Limonene-1,2-epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17600</name>
        <name evidence="3" type="ORF">AWC31_05120</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851092.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05120"/>
    <dbReference type="EnsemblBacteria" id="KWX22767">
        <property type="protein sequence ID" value="KWX22767"/>
        <property type="gene ID" value="AFM11_17600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10664">
        <property type="protein sequence ID" value="ORX10664"/>
        <property type="gene ID" value="AWC31_05120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.875"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013100">
        <property type="entry name" value="LEH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07858">
        <property type="entry name" value="LEH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LEH" evidence="1">
        <location>
            <begin position="11"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="144" mass="16053" checksum="46F15F856D7ECC54" modified="2016-06-08" version="1">MADQSSTTVQDPTTTVEVFLNALQDEDFDTAENALAQNLVYQNVGLPTIYGRARAMKLFRSMQGRAGFEVKIHRSAADGASVLTERTDALTFGPLRLQFWVCGVFEVHDGRITLWRDYFDFFDMLKATVRGVAGVVVPSLRTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKT2</accession>
    <name>A0A132PKT2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850594.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19970"/>
    <dbReference type="EnsemblBacteria" id="KWX22951">
        <property type="protein sequence ID" value="KWX22951"/>
        <property type="gene ID" value="AFM11_16350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.618"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021941">
        <property type="entry name" value="DUF3556_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12077">
        <property type="entry name" value="DUF3556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="578" mass="64346" checksum="68376CD966F0EA78" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL84</accession>
    <name>A0A132PL84_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal_L12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850941.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23115">
        <property type="protein sequence ID" value="KWX23115"/>
        <property type="gene ID" value="AFM11_17305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.814"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal_L12" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="88" mass="9115" checksum="0BF9DB7F55CD15FB" modified="2016-06-08" version="1">MGLFGSSDGDLQRRIDALERRVAALERAASAAGHPVAPTPVGGSTEVVASHMVRQLALQGNKIAAIKLLRDETGLGLKEAKDVVDGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLB5</accession>
    <name>A0A132PLB5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="3">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="5" type="ORF">AFM11_16470</name>
        <name evidence="6" type="ORF">AWC31_19850</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">2 residues (Tyr-53 and Arg-56) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850997.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19850"/>
    <dbReference type="EnsemblBacteria" id="KWX23141">
        <property type="protein sequence ID" value="KWX23141"/>
        <property type="gene ID" value="AFM11_16470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16722">
        <property type="protein sequence ID" value="ORX16722"/>
        <property type="gene ID" value="AWC31_19850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.643"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="203"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX16722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="237" mass="25611" checksum="63DD9F99B1DE9F65" modified="2016-06-08" version="1">MQVTVLSGAGISAESGVPTFRDVETGLWAKVDPYEISSTDGWQRHPEKVWAWYLWRHYMMAGVEPNDGHRAVAAWQDYADVHVVTQNVDNLHERAGSTNVYHLHGSLFEFRCDACGSRFEGDLPDMPEPVETVEPPVCPCGGLIRPNVVWFGEALPDAAWQRSVLAVSGSDVVIVVGTSSIVYPAAGLPEAALSAGKPVIEINPERTPLSDSATVSLRETAATALPGLLQRLPVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLE1</accession>
    <name>A0A132PLE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_17380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851034.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01965"/>
    <dbReference type="EnsemblBacteria" id="KWX23160">
        <property type="protein sequence ID" value="KWX23160"/>
        <property type="gene ID" value="AFM11_17380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.830"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="416" mass="43344" checksum="DB8AA3409D730D54" modified="2016-06-08" version="1">MTGLITQFRSFDLPSRLLMVNQFGINLGFYMLMPYLAGYLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTGGFGLLVVADTLPAMLIASAATGFAGALFNPAVRAYLAADAGERRLQAFATFNVFYQAGILLGPLVGMALLAFDFRVTAGVAAGVFAILTVAQLFALPGHRAEPVVERSSVLQDWRSVVANRSFLLFAVAMIGSYVLSFQVYLALPLQAAALWPGSESGLVAALFVVSGLVAVAGQLRITRWFSARWGRGRSLVVGLLLLAVAFVPLAVVPDAGRFGSPVAVAALILAAALLALGSAAVFPFEMDTVVALSGDRLVATHYGFYNTIVGVGILLGNVATGTVIGAARAAGLAELVWLGLMGVGVASALALYVLDRGRHLDARVAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLR3</accession>
    <name>A0A132PLR3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850965.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01945"/>
    <dbReference type="EnsemblBacteria" id="KWX23127">
        <property type="protein sequence ID" value="KWX23127"/>
        <property type="gene ID" value="AFM11_17365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.826"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="30986" checksum="E4D3BB976758CABA" modified="2016-06-08" version="1">MNAPQKIAAYTAALAVVFAVALGLGTLWGPVDAPVSTPADHPEPVATDAQDAYTLELAQPLVQAGKQVPVRFRIVDGSNVAVTEYVESHEKQLHLIVVRRDLAGYQHVHPTMDDTGTWSIPLNFSEAGDYRVFADSVPRGGDATTLGADLRVAGDYRPRPLPPPATTTTVDGYTVALAGAPTAGESSELTLSVSRDGKPVTDLQPYLGAYGHLVALRAADLDYLHVHPMGDPADPATPAGPGIGFHTSFPSAGEYRLYLDFKHRDVVRTAEFTLSVPATGQQGTAPDGHGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLX6</accession>
    <name>A0A132PLX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4,5-9,10-diseco-3-hydroxy-5,9, 17-trioxoandrosta-1(10),2-diene-4-oate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16215</name>
        <name evidence="3" type="ORF">AWC31_16820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850510.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16820"/>
    <dbReference type="EnsemblBacteria" id="KWX23351">
        <property type="protein sequence ID" value="KWX23351"/>
        <property type="gene ID" value="AFM11_16215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18059">
        <property type="protein sequence ID" value="ORX18059"/>
        <property type="gene ID" value="AWC31_16820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7368"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="47"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="298" mass="32926" checksum="758E5493B9B10400" modified="2016-06-08" version="1">MTSFAAEAAQQQEITFESTSRYAQVRAGDLDMRLHYHEAGDPEAQTIVLLHGGGPGASAWSNFGRNVAVLAEHFHVLAVDQPGYGHSDKHTEHEQYNRYSAKALLGLFDHLGLQGRIPLLGNSLGGGTAVRFALDYPDRAGKLVLMGPGGLSVNLFAPDPTEGVKLLGKFTADPTRENMEKFLRIMVFDQKLVTPELVEERFQIASQPESLAAARAMGKSFAGPDFELGMMWREVYKLRQPVLLIWGREDRVNPLDGALVAVKQIPRVQLHVFGQCGHWAQVEKFDEFNKLTIDFLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM60</accession>
    <name>A0A132PM60_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850515.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16835"/>
    <dbReference type="EnsemblBacteria" id="KWX23354">
        <property type="protein sequence ID" value="KWX23354"/>
        <property type="gene ID" value="AFM11_16230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7371"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="29361" checksum="914989264DA65BAA" modified="2016-06-08" version="1">MAGRVEGKVAFITGAARGQGRSHAVRLAQEGADIIAVDICRQISSNSVIPPSTPDDLAETADLVKALNRRIVTAEVDVRDFDALKAAVGGGVEQLGRLDIIVANAGIGNGGETLDKTSEQDWDDMIGVNLSGVWKTVKAAVPHLLSAGRGGSIVLTSSVGGLKAYPHTGHYIAAKHGVVGLMRSFAVELGQHSIRVNSVHPTNVNTPMFMNEGTMKLFRPDLENPGPNDLAVAAQFMHVLPIGWVEPVDISNAVLFLASDEARYVTGLPVTVDAGSMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMF8</accession>
    <name>A0A132PMF8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EccD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_14720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849921.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18180"/>
    <dbReference type="EnsemblBacteria" id="KWX23519">
        <property type="protein sequence ID" value="KWX23519"/>
        <property type="gene ID" value="AFM11_14720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7053"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044049">
        <property type="entry name" value="EccD_transm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19053">
        <property type="entry name" value="EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017804">
        <property type="entry name" value="Secretion_EccD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="EccD" evidence="6">
        <location>
            <begin position="141"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="491" mass="51884" checksum="E2085441DB25908D" modified="2016-06-08" version="1">MTLPPSLADLETPSGTDTGLTRVTVLVGDLRLDVGLPEDLEIRSYMADLLDIANAQLTARGATHVRFDDTADRWSLAPLGRPVIEPDRTLSSAGVFDGDVLIVRACATPSVPTLFDDIEGAANASTARRWLSSHRTALVAFSFAFLAAVAWSWQLPQTGPAVVAAAVTLACGVILVGAACAVTRRDDGLFASVALSVLAVPLLFTGSLCVIPDGFAVPSLPLAFGVVALAAQLILQITRTGHVFHSFVIALSLLGGATAIAVNLWHPQPRALGAVVSTVSVIVLYLAPRVTILLSRLPLPRVPTAGEPLDEIETHGGATVEGVSAIGLQVIPTEERLLHRVRRANEYLTGILVGVGITAMFGCYLAVDTSDGFYWQGTLFAVVVAAAMCLRGRTHHDLVQSATMIGAGLSIAVLTVFKIAAELPAWHARAGLAAVALATLALLCGLIAPRLDFSPVMRRWVEILEYLAIGLVFPLCFWIVGLYGYVRGLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMG2</accession>
    <name>A0A132PMG2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_14785</name>
        <name evidence="6" type="ORF">AWC31_18115</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849948.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18115"/>
    <dbReference type="EnsemblBacteria" id="KWX23531">
        <property type="protein sequence ID" value="KWX23531"/>
        <property type="gene ID" value="AFM11_14785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17234">
        <property type="protein sequence ID" value="ORX17234"/>
        <property type="gene ID" value="AWC31_18115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7068"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="4">
        <location>
            <begin position="115"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX17234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="180" mass="19857" checksum="8BAAD2E8ABBB13C5" modified="2016-06-08" version="1">MTDAQTTEPGAEVKESAESVAKVEDDLEERLVAEGEIAGDYLEELLDLLDFDGDIDLDVEGDRAVVSIDGGGDLNKLVGRKGEVLDALQELTRLAVHQKTGERSRLMLDIARWRRRRRDELAALGEKVARRVLESGEREELAPMTPFERKIVHDAVAAIDGVRSESEGVEPSRRVVVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMY4</accession>
    <name>A0A132PMY4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02775"/>
    <dbReference type="EnsemblBacteria" id="KWX23624">
        <property type="protein sequence ID" value="KWX23624"/>
        <property type="gene ID" value="AFM11_12515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6593"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031702">
        <property type="entry name" value="DUF5078"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16877">
        <property type="entry name" value="DUF5078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453193" evidence="1">
        <location>
            <begin position="33"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="154" mass="17292" checksum="E83B4CD052C72B5F" modified="2016-06-08" version="1">MTISSMKRRAIAAAAAAAAVAAVAVGPTGVAAADATDEYPIPSNMLRTTCTVDQYMAAVRDTNPVYYERYMIDYKNKPAADQQGARDRIYWFFSLDYAGRRQYSENMATNAFYEQMSWRWPNWAKLFFNNKGVVAHGTKNCATYPAADPTVWTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMY7</accession>
    <name>A0A132PMY7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14945</name>
        <name evidence="4" type="ORF">AWC31_17955</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849995.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17955"/>
    <dbReference type="EnsemblBacteria" id="KWX23557">
        <property type="protein sequence ID" value="KWX23557"/>
        <property type="gene ID" value="AFM11_14945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17299">
        <property type="protein sequence ID" value="ORX17299"/>
        <property type="gene ID" value="AWC31_17955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7100"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX17299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="181" mass="20579" checksum="52FC70893297806E" modified="2016-06-08" version="1">MLELAILGLLLESPMHGYELRKRLTGLLGAFRAFSYGSLYPALRRMQADGLIVEDAAPQGATKVRRARRVYQLTDAGKQRFTELVADTGPQNYSDDGFGVHLAFFNRTPAEARMRILEGRRRQVEERREGLREAVARASSSFDRYTRQLHQLGLESSEREVKWLNELIAAERTAQGRPENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN62</accession>
    <name>A0A132PN62_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849295.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03535"/>
    <dbReference type="EnsemblBacteria" id="KWX23743">
        <property type="protein sequence ID" value="KWX23743"/>
        <property type="gene ID" value="AFM11_13250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6743"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="21771" checksum="6A23742CFE239F8E" modified="2016-06-08" version="1">MAAASSTSEAILRCARASIVAGGYNGFSYADIAAVVGIRKASVHHHFPTKVDLVRTLVMQYRAEAEGGIAEIERHVPDPLDQLRSYAGYWESCIGDPETSYCLCALLATQIPMLPDEIVVELRAYFRTLSAWLTSVLERGVRLGSITLTDEAHSEAETLMAAVHGAMLSARAYGDPQAFAAITRPVIDRLRSRTSPDESGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNB0</accession>
    <name>A0A132PNB0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13795</name>
        <name evidence="3" type="ORF">AWC31_04035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849507.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04035"/>
    <dbReference type="EnsemblBacteria" id="KWX23829">
        <property type="protein sequence ID" value="KWX23829"/>
        <property type="gene ID" value="AFM11_13795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11283">
        <property type="protein sequence ID" value="ORX11283"/>
        <property type="gene ID" value="AWC31_04035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6855"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="336" mass="36837" checksum="28EA7505CEEECF93" modified="2016-06-08" version="1">MPGLPADHELFARAALPSYRRDPETPLRLLSLSENATYLVADDDPMVLRVHRPGYHSLAGIGSELDWMAALRRETPVRTPQLVCSSTGAHVVTAVVGDRELHVDAVSFVPGCTAEEAADAVGFAKLGELTAIMHEHTQRWTPPAGFTRFSWDLDAILGPHARWGNWRAAPALTTEDRAVIRAAVTEITQRLDEFGTGPDRFGLIHADLRLSNLMVDPAAPGTDITVIDFDDCGWSWHLADLAAVLSWIEDAPQADAIISEWLRGYRSVRHLPDDHLALVPTFVMLRRVQLTAWIASHADADAAIAVGADYARGTARLADRYLGDQTWLQDAVFTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNC2</accession>
    <name>A0A132PNC2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="17" type="ORF">AFM11_12970</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849162.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03255"/>
    <dbReference type="EnsemblBacteria" id="KWX23697">
        <property type="protein sequence ID" value="KWX23697"/>
        <property type="gene ID" value="AFM11_12970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6686"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="173"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="329"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="190"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KWX23697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="451" mass="47339" checksum="21A18FF3449882CC" modified="2016-06-08" version="1">MSVLLFGVSHRSAPVSVLEQLSTDEAEQAKIIDQVLQSSLVTEAMVLSTCNRVEVYAVVEAFHGGLSVIGQVLSEHSGMGLNDLTKYAYVRYAEAAVEHLFAVTSGLDSAVIGEAQVLGQVRRAYASAEANHTVGRTLHELAQRALSVGKRVHSETGIDAAGASVVSVALGMAEAKLGGGLAGRTAAVVGAGSMGALAGAHLVRAGVERVHVVNRSLPRARRLAENLTEQGIVADAVALEHLPQALADADVIVSSTGAVRPVVSLADVHHALAQRNASGTEHQLVICDLGMPRDVDPAVAGLPGVWVVDMDRIQREPSARAAATDADAARTIVATEVANYLAGQRMAEVTPTVTALRQRAADVVEAELLRLDNRLPGLDAAHRDEVAKTVRRVVDKLLHAPTVRVKQLASAPGGDSYAEALRELFELDPQAVEAVAASELPFMATDLDKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNE9</accession>
    <name>A0A132PNE9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uroporphyrin-III methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_12960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849576.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03245"/>
    <dbReference type="EnsemblBacteria" id="KWX23869">
        <property type="protein sequence ID" value="KWX23869"/>
        <property type="gene ID" value="AFM11_12960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6684"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="7">
        <location>
            <begin position="303"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="559" mass="58354" checksum="CC8FDA9C5266F432" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP07</accession>
    <name>A0A132PP07_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848526.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24071">
        <property type="protein sequence ID" value="KWX24071"/>
        <property type="gene ID" value="AFM11_11965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="84" mass="9730" checksum="5ED7B80D14C9A190" modified="2016-06-08" version="1">MDSYERDLLKFVLAWAPYGGPREDDVWLEFGMTADQLCGRFARVVTGLLPRVRSLPTPDRCLLEQACVYLRKQRMVARSGERRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP75</accession>
    <name>A0A132PP75_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848653.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09760"/>
    <dbReference type="EnsemblBacteria" id="KWX24115">
        <property type="protein sequence ID" value="KWX24115"/>
        <property type="gene ID" value="AFM11_12215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6522"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="99" mass="10391" checksum="6C26CE84DAC4A13A" modified="2016-06-08" version="1">MIVAFSVSPTGGDDSGSVGAAVAEAVRVVRESGLPNETNAMFTNIEGEWDQVMAVVKRAVEAVAAVSSRVSLVLKADIRPGYTGQLTAKVERIERELGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPC7</accession>
    <name>A0A132PPC7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847033.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05910"/>
    <dbReference type="EnsemblBacteria" id="KWX24191">
        <property type="protein sequence ID" value="KWX24191"/>
        <property type="gene ID" value="AFM11_09315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5900"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="242"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="411" mass="44762" checksum="6C06DEDE335D9A3E" modified="2016-06-08" version="1">MSTDSIYLKRPTGYDAELRSVFRPIFDRIAEGNVTRERDRVFPHEQVRWLGEAGFGTLRIPAEQGGFGASLEQTFQLLAELGQADANVAHIWRNHLAFVEDRLNAPVTEDNNTWIKRFLAGEFVGGGWTEANNVTLANLATTVTAADDHWLVSGAKYYATGSLYADWLDVLGRGDDGELWTALVRADDPGVTLTDDWRGFGQRTTASGSAHYLAARAERGNVFPAAQRFTYQAHFYQIAMLAVLTGITKAAQRDGTAALKERKRNYPQGLSDVPSDDPQLLQVIGELSAEAFGAEAALGRSAQTLDRIVAGRLAGSDDHARQLLIDAEVAVTQAQLVIIGAALRATTRVFDALGASGVSEELALDRHWRNARTLASHNPVVYKARILGEWFVNGKDPVSDLASRGRGGQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPM8</accession>
    <name>A0A132PPM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847369.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05285"/>
    <dbReference type="EnsemblBacteria" id="KWX24299">
        <property type="protein sequence ID" value="KWX24299"/>
        <property type="gene ID" value="AFM11_09940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6024"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="308" mass="32287" checksum="7D593DEF0B695896" modified="2016-06-08" version="1">MGTSHPGGIGTLGGHAVARIGYGAMGLGHQLPQADAVAVLRRAVALGVDHIDTASFYDDGEVNRRIHDALSPYAEDLVIVSKVGARPATGRIPLALAQHPAELRAAVELDLTQLGLDRIPVVNLRRADIGPGVIAEGDQIVDLDDQLAEMITLRDEGKIGAIGISNVDLATLRRALPAGIVCVQNAYSVLNREREAELALCAEHDIAWVPFFPLGSAFPGFPKVAENPVVQRIAGDLGASGAQVGLAWLLAHAPNTLLIAGTTSVEHLEENLRAGDISLSADHLAELDAVWAGASPHGDGVEAFLDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPR1</accession>
    <name>A0A132PPR1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdhD</name>
        <name evidence="4" type="ORF">AFM11_09835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847315.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05390"/>
    <dbReference type="EnsemblBacteria" id="KWX24283">
        <property type="protein sequence ID" value="KWX24283"/>
        <property type="gene ID" value="AFM11_09835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6005"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="277" mass="29689" checksum="D09A1D7DC2659E5D" modified="2016-06-08" version="1">MGRVTARRRAHHVTADHAVARPETLVVEEPLEIRLNGTPITVTMRTPGSDVELAQGFLLTEGIIRQRDDLLTVRYCRGATEESGVSQNTYNVLDVTLAPSVPKPDVDVTRNFYTTSSCGVCGKASLEAVRLISRHCPGDDPSTVAAETLSAMPHQLRDAQKVFASTGGLHGAALFTVDGTMLVVREDIGRHNAVDKVIGWALEQNRIPLTGTVLLVSGRASFELTQKAVMAGIPVLAAVSAPSSLAVDLASQSGLTLVAFLRGESMNVYTRPDRVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPS6</accession>
    <name>A0A132PPS6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polar amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_09970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847388.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05255"/>
    <dbReference type="EnsemblBacteria" id="KWX24305">
        <property type="protein sequence ID" value="KWX24305"/>
        <property type="gene ID" value="AFM11_09970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6030"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="15"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="220" mass="23650" checksum="E0B0E4F7AA50CCA9" modified="2016-06-08" version="1">MQLYYGDLIPYLPALLKGLAVSIGVSLVAAIVGGAFGILLYAGRTSRVSVFRAASSAYVEIIRNTPLLLQLYLVYFALPQAGVNLDPVAAGILALSINNAAYMAEIYRAGFQSVPAGLREAGAALGLSPRDTFWRVLFPPAMRNVLPAITNQTILLFLASSITSVVSLPDLMHVMMGITSTTFRTIEAFTVGGLLYFAVAFLIASLSRIVETRFIKWKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ33</accession>
    <name>A0A132PQ33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847707.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19035"/>
    <dbReference type="EnsemblBacteria" id="KWX24405">
        <property type="protein sequence ID" value="KWX24405"/>
        <property type="gene ID" value="AFM11_10600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6160"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032407">
        <property type="entry name" value="MHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016572">
        <property type="entry name" value="UCP010611"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010611">
        <property type="entry name" value="UCP010611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04529">
        <property type="entry name" value="MTB_hemophore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453495" evidence="1">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="113" mass="11759" checksum="0AAE482AE0A40094" modified="2016-06-08" version="1">MVKLSRLKLAIAAGGFALAALPFSVGVASAEPDFGAVVNTTCTYEQVMAALNSQEPALAQQFNASPFAQSALRSFLASGPAERQRTVTQLQGSPMAAQYFGPIQSIAGSCNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQP6</accession>
    <name>A0A132PQP6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hist_deacetyl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846365.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24658">
        <property type="protein sequence ID" value="KWX24658"/>
        <property type="gene ID" value="AFM11_08255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5502"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016575">
        <property type="term" value="P:histone deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="His_deacetylse_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="36"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="372" mass="39355" checksum="787AA8F5EC0B7941" modified="2016-06-08" version="1">MDRIAIFWDERVLDHDTGVALHEGAASPWITAPQPHTEGPARVRAMHDVLSRGPLAGQLTWHPGRLATEAELATVHPTEYIDRVRTLAETGGWATATTRAGAGSYDPLRAAAGTALEAGAAVLDGRSRMAYALIRPPGHHAQRAQADGYCFFNHAALAAELALRSGVPRVLTVDWDVHHGNGTQDIFYARQDVLTTSIHMNHGAWGPSHPQTGGADEVGTGEGAGYNVNVPLPLGAGDAAYLRAFDEVIAPIARTYQPGLIVAASGQDASAFDPNGRHNVSMTGFRGIGQRLAALADEVCDGRLVVVQEGGYNPSYAPYCLLATLEGLLGADPTPDPLAYVPDQTLGVDAALAAVVEQHRDVWFALSDHPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQS6</accession>
    <name>A0A132PQS6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846454.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00300"/>
    <dbReference type="EnsemblBacteria" id="KWX24688">
        <property type="protein sequence ID" value="KWX24688"/>
        <property type="gene ID" value="AFM11_08445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5537"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="42"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="38102" checksum="5918AE9781841C89" modified="2016-06-08" version="1">MTQDTSETCPVTSGSAAPAAGCPASGGYEALPDVLGPDSLTWQIFGDWRGLLQGPWAGSMQNMHPQLGAAVEQHSIFFRERLPRLLRSLYPIGGVVFDGDRAPQTGAQVRDYHIGIKGVDSLGRRYSALNPDVFYWAHSTFFMGTILTAEHFGGGLTEDQKRQLFDEHITWYRQYGMSMRPVPKTWEEFQVYWDHMCRNVLENNYAAREVLDLSTMPKHPSLQWIPDPLWKLNLKLLGPFAVWVTVGLYDPPVRELMGYTWSERDEKLHRLFGKLVHYTFKMLPKRRRMHPRARAGWDRATGRLPADAPLLETPARNLPPLDARGNPWHYCPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQW7</accession>
    <name>A0A132PQW7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846385.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00180"/>
    <dbReference type="EnsemblBacteria" id="KWX24664">
        <property type="protein sequence ID" value="KWX24664"/>
        <property type="gene ID" value="AFM11_08290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5509"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="147" mass="17060" checksum="01F1B79454E73740" modified="2016-06-08" version="1">MAVQASTEVVFDAPPEAIMDVLADVDALPAWSSLHRHVEVIDRHPDGRPHHVKATMRLLGITDKELLEYHWGEHWMVWDAEANLQQRGQHVEYNLTPEVDRTRVRFDIIVDLAMPIPEFLIKRAKKLVLDVATEQLRRRVMSKAQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQY5</accession>
    <name>A0A132PQY5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13780"/>
    <dbReference type="EnsemblBacteria" id="KWX24715">
        <property type="protein sequence ID" value="KWX24715"/>
        <property type="gene ID" value="AFM11_08590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5569"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="326" mass="34852" checksum="D5CA43CD51CC949F" modified="2016-06-08" version="1">MPAETLRCLVTGATGYIGGRLVPELLEAGHAVRAMARTPAKLDDATWRDRVEVVRGDLTEPESLTSAFEGMDVVYYLVHSMGTSKDFVADEKRSARNVVEAARAAGVGRLVYLGGLHPHGAELSRHLESRVEVGRVLLASGIETVVLQAGIVVGSGSASFEMIRHLTDRLPAMTAPKWVHNRIQPIAVDDVLHYLTAAACASVPGSRTWDVGGPDVMEYGEAMQVYADVAGLRRRLIVVLPFLTPAIASWWVGLVTPIPSGLARPLVESLECDAVMGEHDIDDVIAPPSGGLTGYRDAVTQALQGDGTAADSGRRRLLRFSSTAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR05</accession>
    <name>A0A132PR05_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Steroid delta-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846659.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13505"/>
    <dbReference type="EnsemblBacteria" id="KWX24759">
        <property type="protein sequence ID" value="KWX24759"/>
        <property type="gene ID" value="AFM11_08865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5621"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="141" mass="15289" checksum="FD9C5F2AC2531637" modified="2016-06-08" version="1">MTETQEVSPARAASLASWRCVQSGDKDGWLALMADDVVIEDPIGEAVTNPDGTGVRGKEAVSAFYDTNIGPNELTVTCEETFPSSSPSEIAYILVLHTKFPNGFTATVRGVFTYKVNDAGLITNLRGYWNMDAMKFGQEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR52</accession>
    <name>A0A132PR52_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846810.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13225"/>
    <dbReference type="EnsemblBacteria" id="KWX24806">
        <property type="protein sequence ID" value="KWX24806"/>
        <property type="gene ID" value="AFM11_09145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5678"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="177" mass="18357" checksum="9BB5ED8C760BBBE6" modified="2016-06-08" version="1">MPLYSFEGHTPKVDSAAFVAPTATLIGDVTIEAGASVWFNTVLRGDFAPIVIREGANVQDGSVLHAPPGIPVDIGPNATVAHMCVVHGVHVGAEALIANHCTVLDGAVIGRRSLIAAHSLVVGGTKIPDEVLVTGSPAKVRGPIAGTGAEMWVNSNPRAYRDLAERYLRGLEALPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRR9</accession>
    <name>A0A132PRR9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="11" type="ORF">AFM11_05420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844982.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12795"/>
    <dbReference type="EnsemblBacteria" id="KWX24887">
        <property type="protein sequence ID" value="KWX24887"/>
        <property type="gene ID" value="AFM11_05420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4273"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX24887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="427" mass="45509" checksum="3CD6DFD0301CE49B" modified="2016-06-08" version="1">MAAKNTKATETDTTDTAVEAPGIESTAALPKHGFFVRLYTGTGAFEVIGRRKLWYTVSGIIVAISIAAMVLRGFTFGIDFEGGTKVSMPTAGAQGTITVQQVEDVFNKTLGRAPESVVTVGSGGSATVQIRSETLSNEEAEKLRTALFDAFQPKGSDGQPSKQVISDSAVSETWGGQITQKALIALVVFLVLAAIYITWRYERYMAIAALATLVFDLVVTAGVYALVGFEVTPATVIGLLTILGFSLYDTVIVFDKVEENTNGFEHTTRRTFAEQANLAVNQTFMRSINTSLISVLPIVALIVVAVWLLGVGTLMDLALVQLVGVIVGTYSSIYFATPLLVSLRERTELVRKHTRKVLNRRQPGKAGATKSAQPATAESDHVEHSDSEPVSAGAGQPAAAKPAPGARPSRPSTSKTGRPSGKRTTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSG7</accession>
    <name>A0A132PSG7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphoribosyl isomerase A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="10">5.3.1.16</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="10">PRAI</shortName>
            <ecNumber evidence="10">5.3.1.24</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">priA</name>
        <name evidence="10" type="synonym">hisA</name>
        <name evidence="12" type="ORF">AFM11_06880</name>
        <name evidence="13" type="ORF">AWC31_28770</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in both the histidine and tryptophan biosynthetic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="10"/>
    <dbReference type="EC" id="5.3.1.24" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845477.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28770"/>
    <dbReference type="EnsemblBacteria" id="KWX25137">
        <property type="protein sequence ID" value="KWX25137"/>
        <property type="gene ID" value="AFM11_06880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13787">
        <property type="protein sequence ID" value="ORX13787"/>
        <property type="gene ID" value="AWC31_28770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4575"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010188">
        <property type="entry name" value="HisA/PriA_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01919">
        <property type="entry name" value="hisA-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX25137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX13787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="244" mass="25293" checksum="78F0280170603FB5" modified="2016-06-08" version="1">MSLILLPAVDVVGGQAVRLVQGKAGSETDYGSALEAAEAWQRDGAEWIHLVDLDAAFGRGSNRELLAEVVGKLDVDVELSGGIRDDDSLKAALATGCARVNIGTAALENPQWCARAIAEYGDKVAVGLDVQIVDGAHRLRGRGWETDGGDLWEVLERLDREGCSRFVVTDVTKDGTLTGPNLELLSAVAGRTDAPVIASGGVSSLDDLRAIATLTGSGVEGAIVGKALYAGRFTLPQALAAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSR8</accession>
    <name>A0A132PSR8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844190.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21395"/>
    <dbReference type="EnsemblBacteria" id="KWX25396">
        <property type="protein sequence ID" value="KWX25396"/>
        <property type="gene ID" value="AFM11_03770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2630"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012853">
        <property type="entry name" value="CPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007531">
        <property type="entry name" value="CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR007531-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR007531-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="191" mass="21149" checksum="B93CC0E181706917" modified="2016-06-08" version="1">MSFTSPGQVVLLNGVSSSGKSTIARQLLADFESPWFHMAVDMFGAMRAEQRTHECSPADLREVLRRTRAGFHRAVAGMARAGNDIVMDHVLSEPWRLRDLLKVMAGIDVVFVGVHCAVADAHEREGRRRDRSLGTAIGQIATVHAHRIYDVEVDTSTDSAESCSAQIRNYLRHPAPRARAFDRLRESAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT01</accession>
    <name>A0A132PT01_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843951.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25327">
        <property type="protein sequence ID" value="KWX25327"/>
        <property type="gene ID" value="AFM11_03300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2535"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="152" mass="17216" checksum="67497518D82FA918" modified="2016-06-08" version="1">MAEQHSTARIALRALVDEYALASDTADLERFGSLFTVDGEFVTSAPGSTEPVTLRGREQVKFGPSGNQMFEQTFHAVHNHIVDVDGDRAKGITYCTARHLLRNADGSLEVILAPIRYIDDYALTADGWKFARRELEWTWLERRPAQPPEPWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTD3</accession>
    <name>A0A132PTD3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_04595</name>
        <name evidence="6" type="ORF">AWC31_20550</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844560.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20550"/>
    <dbReference type="EnsemblBacteria" id="KWX25524">
        <property type="protein sequence ID" value="KWX25524"/>
        <property type="gene ID" value="AFM11_04595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16442">
        <property type="protein sequence ID" value="ORX16442"/>
        <property type="gene ID" value="AWC31_20550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2798"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX16442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="257" mass="27955" checksum="86510D5172BE376B" modified="2016-06-08" version="1">MTQLVPEAAASEPEGTVKIRIEGLKKSFGDLVVLDGITTTISKGEVVCVIGPSGSGKSTFLRCLNKLEDITGGKVTVDEFDLTDRKVDLDKVRQHIGMVFQHFNLFPHMTVIDNVTLAPLLTKKMDKAAAEKRAMELLTQVGLAEKAHVKPATLSGGQKQRVAIARALAMNPSIMLFDEATSALDPEMVGDVLEVLRELAEGGMTMVVVTHEMGFAREVASRVIFMADGNIVEDDTPAEVFDNPKHPRLQEFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTH7</accession>
    <name>A0A132PTH7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25649">
        <property type="protein sequence ID" value="KWX25649"/>
        <property type="gene ID" value="AFM11_02985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2465"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032407">
        <property type="entry name" value="MHB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04529">
        <property type="entry name" value="MTB_hemophore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453329" evidence="1">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="117" mass="12806" checksum="477AC8C106462119" modified="2016-06-08" version="1">MTLVASSCIALMGLSTGVAAAKPLDPVINTTCNYDQIVAALRVEAPELAGVLDANPEAQAKLHELVALSPDQRRQRIDQRLAANPDWRTTLDQKRATPQGQEKEKMLLRVAQTCHNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTS2</accession>
    <name>A0A132PTS2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842056.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25739">
        <property type="protein sequence ID" value="KWX25739"/>
        <property type="gene ID" value="AFM11_00090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.18"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="306" mass="30553" checksum="F122C3B8835F14B2" modified="2016-06-08" version="1">MDVDVTEPIPEVTTLAERVQGQLSPSRIIAGISTTVAVVAVGALIWVTGQQPDTAPPESPSPAVASGPAAHAQPVAAHPPAPQAALPAPPSTPAPAPAPSAAPAASSTGGLADLFKPPTATAPRSPSTSETSGDSQAPTISWPGFDTGFRPDASWAPSLAAANAAPSADAVIAAVSGTAGWVGGGALDVLGDIIIASSNGRQNPGVPQPTSLAALMLGPAATAGTGLPSLPPPPQVDWSKLPPPNVDLSKIPPPNVDLSKIPPPQMPQVDWSKIPPPQLPPPPQMPRIEDPFAKLPSITRAVGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTV5</accession>
    <name>A0A132PTV5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="13">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">kdpB</name>
        <name evidence="15" type="ORF">AFM11_04315</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="13"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844464.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20840"/>
    <dbReference type="EnsemblBacteria" id="KWX25482">
        <property type="protein sequence ID" value="KWX25482"/>
        <property type="gene ID" value="AFM11_04315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2741"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="680"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="398"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX25482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="707" mass="74238" checksum="7123080BABB15ED0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU00</accession>
    <name>A0A132PU00_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsN</name>
        <name evidence="5" type="synonym">rpsZ</name>
        <name evidence="6" type="ORF">AFM11_00445</name>
        <name evidence="7" type="ORF">AWC31_33560</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_064946110.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33560"/>
    <dbReference type="EnsemblBacteria" id="KWX25800">
        <property type="protein sequence ID" value="KWX25800"/>
        <property type="gene ID" value="AFM11_00445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11614">
        <property type="protein sequence ID" value="ORX11614"/>
        <property type="gene ID" value="AWC31_33560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.90"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX11614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="61" mass="6968" checksum="E5AF6766EDEF3C03" modified="2016-06-08" version="1">MAKKALVHKANKKPKFAVRAYTRCQRCGRPHAVFRKFGLCRICLREMAHAGELPGVQKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUM5</accession>
    <name>A0A132PUM5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="1">1.1.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Oxalosuccinate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_01860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the monomeric-type IDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842959.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34640"/>
    <dbReference type="EnsemblBacteria" id="KWX26020">
        <property type="protein sequence ID" value="KWX26020"/>
        <property type="gene ID" value="AFM11_01860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.382"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004436">
        <property type="entry name" value="Isocitrate_DH_NADP_mono"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36999">
        <property type="entry name" value="PTHR36999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03971">
        <property type="entry name" value="IDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009407">
        <property type="entry name" value="IDH_monmr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00178">
        <property type="entry name" value="monomer_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="134"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="84"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="587"/>
            <end position="588"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="603"/>
            <end position="605"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX26020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="745" mass="82591" checksum="559E5EB916F53D1F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUV3</accession>
    <name>A0A132PUV3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843197.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35090"/>
    <dbReference type="EnsemblBacteria" id="KWX26095">
        <property type="protein sequence ID" value="KWX26095"/>
        <property type="gene ID" value="AFM11_02310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.473"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="315" mass="32682" checksum="9F6AD5C83F0E4301" modified="2016-06-08" version="1">MTTPITTPFNSESTAADVIDGVDLSGNSAIVTGAASGIGVETARALAAAGAAVTLAVRDVAAGERVAADLRTSTGNDAITVGALDLTDLASVAAFTLAWSGPLHILVNNAGVMAVQQLTRSAGGHELQFATNHLGHFALATGLHRALAAAGGARVVSVSSSGHLRSPVVFDDIDYAFRDYDPFGAYGQSKTANVLFAVEATRRWRDDGITANALMPGGILTALQRHLDPAYGEQAAERFRQAGSRLKTVEQGAATSVLLAASPLLEGVGGRYFDDCNEAVVVDHRDEFGISGVAPYALDPGNAQRLWELSQRLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUW4</accession>
    <name>A0A132PUW4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ppx-GppA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843760.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35400"/>
    <dbReference type="EnsemblBacteria" id="KWX26148">
        <property type="protein sequence ID" value="KWX26148"/>
        <property type="gene ID" value="AFM11_02625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.538"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="33"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="340" mass="37110" checksum="C4861817E2BE7619" modified="2016-06-08" version="1">MRLGVLDVGSNAAQLQVVDAFAGAPPLPIRAVKIPTRLGEEASSDGAIGQSGMDRIVAAVRVAVESAHALHVDQLYPFVTAAIRDSSNRDEVLQLVADETGTRLRYLSGEQEARLTYFAVRSWYGWQAGRLLNIDIGGGSMELAFGRDAIPDLAVSLPLGAGRVSTMFLRPDPPSKAQVKDLRRHVRQQVREVANRVQWEGTPRRVVATSKTFKQLARFGGAACGRKGPFVRRTVSRTQVAQSIQNLMGVSVQERAQFRGIKPARAWQILGGAVVAYETMRCLGIDQAEVSPWALREGIMLEYLSSLRIPEGELSLQPLAFDRSSEDPAQANVTTLPRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV09</accession>
    <name>A0A132PV09_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843472.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35615"/>
    <dbReference type="EnsemblBacteria" id="KWX26181">
        <property type="protein sequence ID" value="KWX26181"/>
        <property type="gene ID" value="AFM11_02835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.584"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453325" description="SGNH_hydro domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="59"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="26166" checksum="420400889F4E2A04" modified="2016-06-08" version="1">MTSGSLRGRWLAGLLIVIGVVALAGGVAWASAGNRVATSPPARVQLEPPPPPERPALAVLGDSFSSGAGADWQTGWVQLVADSMCWTVLPASRPRGIGAQGGTGYTTAAADIGKLRYGDRVDAVMAGNPQIILVQGGINDRAARSEAITEAAAETFRAVKAKAGDAEFIVIGPVAPPDPTIPPEESARVSGAIAAAAHNVGVPYIDPVAERWLTNPAMWSPDHTNPNREGYREYAQRLVDKFVQAGVKPSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV47</accession>
    <name>A0A132PV47_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitomycin antibiotics/polyketide fumonisin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843550.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33270"/>
    <dbReference type="EnsemblBacteria" id="KWX26206">
        <property type="protein sequence ID" value="KWX26206"/>
        <property type="gene ID" value="AFM11_00160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.33"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="230" mass="24456" checksum="0E0300DBB36015FE" modified="2016-06-08" version="1">MRDGFVKVEQAAPVEIADAARDLLWKQIGLSPDEPASWTQPVVWAADLTGQGPFGELAGSRVLSEALDQVCGPGGWAPRGALGNIPIRFPVSPPAEDRGWHIDLNTPISAEHWVISGRPHTMLLLTLLSEVGPDDAPTRIRVGSHRDVAAVLGEDSVEFADSGKLVDDASAGRPVALATGRPGDMYLVHPFTVHAADEHRGATPRFMSQAPIMLTEPLSPSSPSALACVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV87</accession>
    <name>A0A132PV87_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PduH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843590.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26225">
        <property type="protein sequence ID" value="KWX26225"/>
        <property type="gene ID" value="AFM11_01000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.206"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010254">
        <property type="entry name" value="B12-dep_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003208">
        <property type="entry name" value="Dehydtase/Dehydtase_re"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02288">
        <property type="entry name" value="Dehydratase_MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52968">
        <property type="entry name" value="SSF52968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="112" mass="11354" checksum="AEEA1B2705C3BE3C" modified="2016-06-08" version="1">MVVVSAAGGGAIEREVLAGIEEEGVPYSLVPTGSDAAAADLARQAAMRSPLRVGIGLDVTGDVCVHHDQLADVLPDLSSGGAADAGTARTLGHNAARIVVGLPLKRQNRFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVB0</accession>
    <name>A0A132PVB0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske-type oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_02785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843774.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35565"/>
    <dbReference type="EnsemblBacteria" id="KWX26299">
        <property type="protein sequence ID" value="KWX26299"/>
        <property type="gene ID" value="AFM11_02785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.573"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX26299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="375" mass="42828" checksum="9A28ADB8DAD60D28" modified="2016-06-08" version="1">MSDIREIDAGTAMTRFARGWHCLGLADDFRDGQPHGIEAFGTKLVVYADSAGALHILDAYCRHMGGDLSRGSIKDDNLACPFHDWRWGSDGKCKLVPYAKRTPRLARTRKWPTHEVNGQLLVWHDPEGSTPPPELIPPTIEGYAEGIWSPWQWNSILIEGSHCREIVDNNVDMAHFFYIHHAYPTYFKNVIEGHTASQYMESKPRPDYTTNPDKLWDGTYLRSEATYFGPAYMINWLHNDLGPGFTVEVALINCHYPVTHDSFVLQWGVAVQQMPGLPAEKAAKLAAAMGRSFGDGFLEDVEIWKHKTRIDNPLLTEEDGAVYQHRRWYEQFYVDLADVTPDMTDRFELEVDTTHAFELWQQEVEDNLARRASVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAX4</accession>
    <name>A0A132PAX4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A biosynthesis acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_35730</name>
        <name evidence="7" type="ORF">AWC31_12690</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000047">
        <property type="protein sequence ID" value="KWX19470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859941.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12690"/>
    <dbReference type="EnsemblBacteria" id="KWX19470">
        <property type="protein sequence ID" value="KWX19470"/>
        <property type="gene ID" value="AFM11_35730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18910">
        <property type="protein sequence ID" value="ORX18910"/>
        <property type="gene ID" value="AWC31_12690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5882"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX18910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="298" mass="32999" checksum="4D16880BF8DE676B" modified="2016-06-08" version="1">MPLGEHVTDLGYAAGWRLVRALPERMARNMFGAGARYAARNGGPAQLRKNLARVTGVSPAEVPDALMRASLASYARYWREAFRLPTMDHQVLGKQLDVLDIELVWAAIEAGRGAVLALPHSGNWDMAGVWLVQNYGTFTTVAERLKPESLYHRFVAYRESLGFEVLPLTGGARPPFEVLAERLTDNRVICLMAERDLTRNGVPVDFFGEATRMPAGPAKLAIETGAALLPVHCWYEGDGWGMRVYPELDTSSGDVMVVTQALADRFADNIAAYPADWHMMQPQWLADLSDERRARLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAZ9</accession>
    <name>A0A132PAZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859797.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02705"/>
    <dbReference type="EnsemblBacteria" id="KWX19486">
        <property type="protein sequence ID" value="KWX19486"/>
        <property type="gene ID" value="AFM11_35545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5844"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="229" mass="24903" checksum="6326F244E76511A9" modified="2016-06-08" version="1">MVVMIKAVLFDFSGTLFRLEEDESWFAGIAVDEREVDGHVQAELMRRLTAPTGRSVQMSDEQYHAWVNRDLAPHLHREAYLHVLRESGLADHHAVELYERVIDPDSWTAYPDTATVLKTLKQQGIKTAVVSNIAFDIRPAFAAIGAKDDVDEFVLSFEVGAVKPNAAIFTTALDRLGVAAPDALMVGDSEEADGGAKAVGCRFALVDPLPTAERPDGLLTALTTSGIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB97</accession>
    <name>A0A132PB97_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dibenzothiophene desulfurization enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_34995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859602.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02025"/>
    <dbReference type="EnsemblBacteria" id="KWX19603">
        <property type="protein sequence ID" value="KWX19603"/>
        <property type="gene ID" value="AFM11_34995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5728"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="226"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="450" mass="49968" checksum="85DC42862E08D8F5" modified="2016-06-08" version="1">MTRQLHLGGFQIASQVTHSHAAWRHPGSDTAFTTPEYYHRIGRILERGKFDFVFFADLLAAPVRFGDDISEPLRRGTQATATLDPSIVAASIGAVTSKLGVAITKSATYFHPYELARIFASLDHITRGRVAWNIVTSLTQGEAQNFGHDEHLDHEFRYERAEEFVRTALELWSSWDPDALVLDKADGVFADPSRVRQVDHDGQYFRSRGPLNVPHSPQGRPVLIQAGSSNTGRDFAARWAEAIFEIDPTPEGRRAYYDDIKSRATNFGRNPDGVLIFPAFIPFIGETESIAREKQAFHNELADPISGLITLSVHTDHDFSRYDLDAPVENVQVTGTQGLFDTARRVANRDNLTLRDVGNWYAQGVLLPQFVGTAAQVADQIEESFRAGEADGFMVSAAQTPGTFNDFVDYVVPELQRRGLYRTEYTGDTLRDHLGLTGLSQPHGVAHAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBF4</accession>
    <name>A0A132PBF4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19661">
        <property type="protein sequence ID" value="KWX19661"/>
        <property type="gene ID" value="AFM11_34560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5257"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="147" mass="16105" checksum="13CB5A7C6ADB810A" modified="2016-06-08" version="1">MRAQILRERSTACRLLVVLDGDATGDEQAQRLVDEGLLELRNIFILRGKGRKSSEIEDLINPQVYLGSLSKKFGRTFTTKHFSSMNRKWSDSFTSAAGVLGLSGSQSANLKTAKMTVADAVRSSDLPLIRESAEDGVEALRSAIWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBH1</accession>
    <name>A0A132PBH1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin MazE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859365.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19670">
        <property type="protein sequence ID" value="KWX19670"/>
        <property type="gene ID" value="AFM11_34620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5271"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021558">
        <property type="entry name" value="MazE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11455">
        <property type="entry name" value="DUF3018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="64" mass="7371" checksum="746DC5F702F645B2" modified="2016-06-08" version="1">MAVRDRVGEYRRRMRERGLRPLQVWVPDVRTETFAAEAHRQASLVARADESGDDQDFVEAISTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBJ6</accession>
    <name>A0A132PBJ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11385"/>
    <dbReference type="EnsemblBacteria" id="KWX19705">
        <property type="protein sequence ID" value="KWX19705"/>
        <property type="gene ID" value="AFM11_34230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5185"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452964" evidence="1">
        <location>
            <begin position="34"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="214" mass="23007" checksum="7B2E7E13CCF252CE" modified="2016-06-08" version="1">MGRHRLAERRRSRRSAVVGAVVIPAATILIAGADTVPTFNPEVRCCAEVKPAAAVAPPVAKPAPAPLPPADARAARRDIRVPLPVGKAPEKGLQVETILAARAVSAAFPEILTIGGVRSDPLKWHPHGLAIDVMIPHYATPEGKALGERIVAYVLDNADRFGVNHIIFRQTLYRHDGSKKRMSDRGGDTANHYDHVHIATNGGGYPTGHETYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBJ8</accession>
    <name>A0A132PBJ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Asp/Glu/hydantoin racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859378.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22215"/>
    <dbReference type="EnsemblBacteria" id="KWX19674">
        <property type="protein sequence ID" value="KWX19674"/>
        <property type="gene ID" value="AFM11_34645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5276"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="25429" checksum="C8538704A019B69F" modified="2016-06-08" version="1">MKILVANVNTTVSMTDAIAESARGVASPGTEIVGITPRFGADSCEGNFESYLAAIAVMDAITSYPEPFDAVIQAGYGEHGREGLQELLDVPVVDITEAAASTAMYLGHKYSVVTTLDRTVPLIEDRLKLAGLDARCASVRASGLGVLELESDPDRAVEAIVHQAREAVENDHAEVICLGCGGMAELEEKVRAATGVPIVDGVRSAVTIAEGLVRMGLSTSKVRTYATPREKKVIGWPFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBK6</accession>
    <name>A0A132PBK6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859177.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19715">
        <property type="protein sequence ID" value="KWX19715"/>
        <property type="gene ID" value="AFM11_34295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5201"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="365" mass="40467" checksum="B718CF27244DD31B" modified="2016-06-08" version="1">MKAFVEWLGTVPAGIWGALAGAVTARVLTWLAERRRNRDAYRAPQRETIGAIIAAANDMKVSLSDALEHMGLTGRQTTDDAAVASLNTFLRRLLALDEQFSIGRLTVVDGPCRDKMLTAYVRFSELRKLANDPAVATPAGFGEFVRQMNDTSNALDTLLAELVDLAERRLSPARPLLSRRPKVKVASNKARSQPNRRRLGLRRRKNDEPAQLDGGAPRADAPTPVTEAEPDADEGRTRNDSAAALRAARQQPNPNSPQPDEREVEVVGEPGTRARIRTELIKGEQLRRQHVGRLLTEGRDGYNIMGRILDLTPVLTDAAESWLVTVHWAALPGQRSRVDRRRIRFSDDVELVEIIEDDDTDPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBQ8</accession>
    <name>A0A132PBQ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Segregation and condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11265"/>
    <dbReference type="EnsemblBacteria" id="KWX19734">
        <property type="protein sequence ID" value="KWX19734"/>
        <property type="gene ID" value="AFM11_34405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5225"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="285" mass="31114" checksum="9AB894BA358B560E" modified="2016-06-08" version="1">MNDVAGTDAAQAVAASDDASGGSQQNRFQVRLTNFEGPFDLLLQLIFAHRLDVTEVALHQVTDDFIAYTKQIGAQLELDETTAFLVIAATLLDLKAARLLPAGEVQDEEDLALLEVRDLLFARLLQYRAFKHVAEMFAELEAAALRSYPRAVSLEDRYSDLLPEVMLGVDAEKFATIAAAAFTPRPVPTVGTDHIHAPKVSVPEQAERLLGLLEQRGVGQWATFTELVADCTAGIEIVGRFLALLELFRARAVAFEQSEPLGVLQVSWTGDRPTSEHLATADAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBR4</accession>
    <name>A0A132PBR4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858992.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32490"/>
    <dbReference type="EnsemblBacteria" id="KWX19760">
        <property type="protein sequence ID" value="KWX19760"/>
        <property type="gene ID" value="AFM11_33960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5129"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453146" evidence="1">
        <location>
            <begin position="26"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="372" mass="39520" checksum="F6F385A4E096D673" modified="2016-06-08" version="1">MRIGKSRLVVLGIAALTAAAVAVTAAVIYTKDQLDTISVTAQFDSAAGLYEGNTVAVLGMPVGKVTKITPKGGYVEVDFTVDRDVKIPADAQAVTISNSILTDRQIELTPPYRGGDVLADHATIGLHRTQTPVEFARVLDVLDKLSVSLRGDGKGNGPVADVVNASAAIADGNGQRMKDALGELSNALRLSADKGTVTRDQLTTIIRNLSSLSEATARNDATMREFGSSVRALSQILADEDLGTGTTGKKINEVLTHTAEVLNTHRDAIKDIVANGDTVLTTAVDHERDLAEFLDVAPMTLDNLYNVVDQKNGALRVKVLTDRVLFDNQFIKEICNVMGLRQLGCSTGTLQDFGPDFGISNMLDGLAAMGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBS2</accession>
    <name>A0A132PBS2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02525"/>
    <dbReference type="EnsemblBacteria" id="KWX19781">
        <property type="protein sequence ID" value="KWX19781"/>
        <property type="gene ID" value="AFM11_34075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5152"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="220"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="330" mass="35165" checksum="30EF3063F2FE6112" modified="2016-06-08" version="1">MKSVPVLAIAGYLGAGKTTLLNHLLRNSRGVRIGALVNDFGAVNIDAMLVAGQVDAMASLSNGCICCAVDAEEAGEMLGKLAAVKPRLDLIVVEASGLAEPAALARTIATADDKRYHYAGLVLVVDAVESARGDLGHSVRVADLVVLNKADQVSADELAAVRAKVATLSPRVPIVPTEFGRLDPALLIDPSEQAPRAGQLSLDEMLWADHEHDEHEHAAFQSVEFISETPLDPRRFMAFLQNRPAGLYRAKGFVDFGAAGSGRKFVMQLVGSSLRFEKQRWGSGEPHRTALVFIGTEMCADSVRDALAECVSVPGENDEQGILGVLRYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBU0</accession>
    <name>A0A132PBU0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859086.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02585"/>
    <dbReference type="EnsemblBacteria" id="KWX19790">
        <property type="protein sequence ID" value="KWX19790"/>
        <property type="gene ID" value="AFM11_34135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5164"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="115" mass="13047" checksum="CA593BF5CAAEF7D7" modified="2016-06-08" version="1">MTQYTYRAEWLPDEKEYIGRCLEFPLLWSRGLSAGAAIADIEKQVEQEVADLLASDMDPPESLTDRHYTGKFMVRASPMLHARLTVEATEQGVSLNQWVIQKLAGRPPVSLSDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBV1</accession>
    <name>A0A132PBV1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mercuric reductase</fullName>
            <ecNumber evidence="12">1.16.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_33690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.1" evidence="12"/>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858834.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08065"/>
    <dbReference type="EnsemblBacteria" id="KWX19813">
        <property type="protein sequence ID" value="KWX19813"/>
        <property type="gene ID" value="AFM11_33690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5074"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016152">
        <property type="term" value="F:mercury (II) reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="7"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="345"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="8">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX19813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="458" mass="49135" checksum="212B51474B1FF381" modified="2016-06-08" version="1">MAPAQKYDAIVIGAGQAGPPLAGRLTADGQTVAVIERKLVGGTCVNYGCIPTKTLVASAHAAHLARRGAEYGVGTGDIAVDMAKVKARKDKIMLDDRHGVESWLEGMDGATLIRGHARFVDPHTVDVDGQLLTADKIFLNVGGRAVAPDFPGLDGIDYLTNVGILELDSLPEHLVIIGGSYIALEFAQMYRRFGAQVTVIEKGPRLTSREDEDVSATIKEILEAEGITVVLDAAGIRFTKRDNGFEVVPADGAEPIVGTHLLMAVGRVPNTDDLGLENAGVETDKRGYVVVDDQLRTNVEHIWAMGDCNGKGAFTHTSYNDFEIVAANLLDDDPRRVSDRVTTYALYIDPPLGRAGMTVEQVRASGRKALVGKRPMTRVGRAVEKGETQGFMKVVVDAETEEILGAAILGVGGDEVIHSILDIMTAKKPYTAISRTMHIHPTVSELVPTMLQDLKPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC32</accession>
    <name>A0A132PC32_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858715.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19891">
        <property type="protein sequence ID" value="KWX19891"/>
        <property type="gene ID" value="AFM11_33470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5027"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="100" mass="10722" checksum="665605F8F99F151F" modified="2016-06-08" version="1">MNESGTAEVGAHLLLCCPLNHHVGNLTQASPDAPDDLVFGPQPWGVYVEGEHFVVECPDCGGGTKVYDNAQVLKEEVNAELSAYPDGSRVTHNLAFWNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC65</accession>
    <name>A0A132PC65_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_33555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19920">
        <property type="protein sequence ID" value="KWX19920"/>
        <property type="gene ID" value="AFM11_33555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5044"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="249" mass="24958" checksum="62CEDF368B6B4670" modified="2016-06-08" version="1">MGFWILVVVGALSGVTTVLFGFGGGFVTVPVIVWADSELGDDAMRTAVATSAVVVFVGAAIATASTRREILVGLRGGSGLVALLAVGGLVGGVAARFVPAVVAQWGFVAYLALTLADAVIRPGFVRPAAARAEPRTVSARYGLPVGAVAAFLGVGGSVLTVPLLRRAGRSMESATALANPLTLAITAPAVVPLVASVDITSAAALLLGATPVIVILRRRRIGMPDAVHARVYLGLIAAVTLAMAAAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCB5</accession>
    <name>A0A132PCB5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858275.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32110"/>
    <dbReference type="EnsemblBacteria" id="KWX19981">
        <property type="protein sequence ID" value="KWX19981"/>
        <property type="gene ID" value="AFM11_32735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4876"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="166" mass="17927" checksum="DF0075333AE045CD" modified="2016-06-08" version="1">MNGLTGTRRVASPVRLTLAKQVGADIDGAWWPHTDSVANELPELVGVLHRRLGEIVDIRINWSAAEGQLDLNTIVTGNKWTVGAKARRPRLMAVAGRDTCVKLLVVPCKTSQLLGGLVMRCAAAMPVDESARQTPFFETADCVLRVAQAESARWLGRMQTPAGTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCJ0</accession>
    <name>A0A132PCJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858370.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32390"/>
    <dbReference type="EnsemblBacteria" id="KWX20014">
        <property type="protein sequence ID" value="KWX20014"/>
        <property type="gene ID" value="AFM11_32945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4919"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="33"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="119"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="326" mass="35285" checksum="7B7FF0D19A416EB0" modified="2016-06-08" version="1">MDREAVAVNPGPLRVLAHFVPGDKVLDFLAPHQDWLDVRFCAEDDDETFYRELPEAEVLWHVLRPISGDDLHRALRLRLVHKLGAGVNTIDVDTATQLGILVANMPGANAPSVAEGTILLMLAALRRLPELDRTTRAGRGWPSDPTLGETVRDLGSCTVGLIGYGNVAKQVERIAQAMGAEVIHTSTRDTGHPRWRSLPDLLAASDVVSLHLPLTDATRGLLGPDQLAAMKPGAVVVNTARGPIIDEPALIDALKSGRLGAAGLDVFETEPLPHDSPLLELPNAVYTPHVAWYTADTMRRYLTAGVENCRRIHDGEPPANVVNKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCS5</accession>
    <name>A0A132PCS5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857761.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20141">
        <property type="protein sequence ID" value="KWX20141"/>
        <property type="gene ID" value="AFM11_31855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4697"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="55"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="150" mass="16647" checksum="92876CFBA9D67B8E" modified="2016-06-08" version="1">MTSGFIKPELTDTNRGFWDGAAEGVLALQRCDDCAELRYPPAQRCPRCLSSDATWQPISGRGEVLSYIVIHQRYHAAWADRVPYNVALIQLAEGPRMISNVVPLDRPDVSVGMPVQVVFDDEDGLRVPRFIGVDEDPAAYRNSAKSQGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCT8</accession>
    <name>A0A132PCT8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ORF">AFM11_31830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857752.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31985"/>
    <dbReference type="EnsemblBacteria" id="KWX20139">
        <property type="protein sequence ID" value="KWX20139"/>
        <property type="gene ID" value="AFM11_31830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4692"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="8"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="197" mass="21748" checksum="84A71239B55EAC81" modified="2016-06-08" version="1">MTTGRRRRVIVGITGASGSILGVRMLERLRELDIESHLIMSAWGARTLEHETTWTAAEVRQLADFTHKPGDLGACVSSGSFHTDGMIVAPCSMKTLAAIACGYTEDLVARAADVVLKERRRLVLLAREAPLSEIHLENMLKLARMGVSIVPPVPAFYNRPKTLDEVVDYIVTRALDQVGIISEEAPRWDGNMTKQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCU7</accession>
    <name>A0A132PCU7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_31990</name>
        <name evidence="7" type="ORF">AWC31_31905</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857834.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31905"/>
    <dbReference type="EnsemblBacteria" id="KWX20165">
        <property type="protein sequence ID" value="KWX20165"/>
        <property type="gene ID" value="AFM11_31990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12565">
        <property type="protein sequence ID" value="ORX12565"/>
        <property type="gene ID" value="AWC31_31905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4724"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX12565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="150" mass="16961" checksum="325467E4085F9D25" modified="2016-06-08" version="1">MTLWFDDLTVGRAWSGASRTVTEADVDGFAELTWDRFPLHTSEEFAKRTAFGTRIAHGLLGLAFAHGLMWANTHELDDSVIAFIGIRDWKFLGPIYFGDTMRVEYEVVEQRRSTTKPDRGVIEFAVRVINQHGDVVQQGVKTMLIGSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCZ7</accession>
    <name>A0A132PCZ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857938.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20200">
        <property type="protein sequence ID" value="KWX20200"/>
        <property type="gene ID" value="AFM11_32205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4768"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="493" mass="53141" checksum="1B6199112EF42617" modified="2016-06-08" version="1">MPDSAQSGASVITAEEIERELALLGRLKSRVTGTAEQEQLVAHIEKQLTDAGLDVRSDTLSFTRWGPSSEASAALHIARRPVPIASVFPYSGVTGPDGVRGQLVRLRGPMPVWRRARRKIAVVEVSNFAVPSSAVIDTWDADAPWPVMHNPLVPTTLAGLGLARARKAGVKAVIFVWRNISDDNARGQYLPFTLGYQGIPAVFVSGKAGEAVLAGAAGRDDASVVLDYQLHPRATTRTIWTTVEGTARPDETVLVVTHTDGVNAVEENGHIATVAMARAAALDPPERTTVFVFTSGHMRIPAVTSAGQATQRFLSDHPELWAGTAGRRCAVAGLAVEHLGAREFIDDPAANQLRPTGRIEPELLYATTPELAHLARRQWRGDKGALPRISKPTPLVQFGEGEPLLHAGIPAISLVSTPLYLLAETTGDESHLVDNAALHRQVDNFERLYREISSVHIDDFGRVRKPTNAARLRGIASLVKAMAATKVLELRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD26</accession>
    <name>A0A132PD26_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20204">
        <property type="protein sequence ID" value="KWX20204"/>
        <property type="gene ID" value="AFM11_31835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4693"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="148" mass="15997" checksum="1347B12C1B9B342E" modified="2016-06-08" version="1">MPQPVADLVNGSDLDHKLGHTLQLVTVDDAGWPRLSLLSVGEVLAGPGDDIRLALHTGSRTTAALTHSGKALITVVLGPTHYKIHLALTRMNPDGAGPLAFFSGSVVHVDEDRVRYAELTSGITYRLNEPDDVLARWTRQIDDLRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD48</accession>
    <name>A0A132PD48_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Urea amidolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_31535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857557.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26115"/>
    <dbReference type="EnsemblBacteria" id="KWX20268">
        <property type="protein sequence ID" value="KWX20268"/>
        <property type="gene ID" value="AFM11_31535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4212"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="5">
        <location>
            <begin position="27"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="347"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="665" mass="72085" checksum="91915650BEA74A3B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDY8</accession>
    <name>A0A132PDY8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiol-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_32095</name>
        <name evidence="5" type="ORF">AWC31_31755</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857888.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31755"/>
    <dbReference type="EnsemblBacteria" id="KWX20182">
        <property type="protein sequence ID" value="KWX20182"/>
        <property type="gene ID" value="AFM11_32095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12540">
        <property type="protein sequence ID" value="ORX12540"/>
        <property type="gene ID" value="AWC31_31755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4745"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="3">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX12540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="295" mass="31154" checksum="9F2CD25B2BF04BDF" modified="2016-06-08" version="1">MTGVGLLGAFLGGLASLLSPCSALLLPSFFAYAFDRVHQLIGRTAAFWAGLCAVLVPLGAGVGVLGNVVTRYRGEVTVIGGLVLIGFGLMALLGKGFGLPAVQRATARINISSTASVIALGAVYGLAGFCAGPLLGAVLTMSAMGADPFYGALLMAVYALGMAAPLFLLAWLWDRFDLAKRSWLRGRPIRLGPLQTHTTSLLTGAVFILLGGVFLFTDGTANLGGVLTVDAQYDLQVWMSRLSSHASDPWVILGVVVALIGWRLYRLWRRRTRSSTDTDDAEPSPNGPTSYYRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE42</accession>
    <name>A0A132PE42_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856585.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25195"/>
    <dbReference type="EnsemblBacteria" id="KWX20601">
        <property type="protein sequence ID" value="KWX20601"/>
        <property type="gene ID" value="AFM11_29855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3863"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="371" mass="41292" checksum="B18B53BC75A57337" modified="2016-06-08" version="1">MLGPMDEFPVHQVPQPIAWPGSSDRNFYDRSYFNAHDRTGDIFVITGIGYYPNLGVKDAFLLVRRGDTQTAVHLSDAIDQDRLNQHVMGYRVDVKQPLHKLRITLDETEGISADLTWSGLFDVVQEQPHILRSGNRVTLNAQRFAQLGSWSGHLTIDGERIAVDPASWIGSRDRSWGIRPIGEAEPAGRPADPPFEGMWWLYVPMAFDEFSIVIIIQEEPNGFRSLNDCTRIWKDGRIEQLGWPRIKIHYRSGTRIPTGATIDATAADGSPVRFDVESKLPVPIHVGGGYGGDSDWIHGVWKGEKFTERLTYDMNDPAIIGRSGFGVIDHVGRAVCTEGDAPPTEGWGLFEHGALGRHDPSGFADWLTVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE65</accession>
    <name>A0A132PE65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gluconate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29745</name>
        <name evidence="4" type="ORF">AWC31_25085</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856532.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25085"/>
    <dbReference type="EnsemblBacteria" id="KWX20584">
        <property type="protein sequence ID" value="KWX20584"/>
        <property type="gene ID" value="AFM11_29745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14475">
        <property type="protein sequence ID" value="ORX14475"/>
        <property type="gene ID" value="AWC31_25085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3841"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX14475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="461" mass="47059" checksum="7536AB9EDD2D29B1" modified="2016-06-08" version="1">MSHTAVLINTAVAILAVVVMIVKFKFNPVVSLVIGSAYLGLAVGLGVEKTIEAITVGFGDIMAEVGLLIAFGVLMGAILQQTGAIERLVEMLLRLFGPKRMPYAMSLTIATALQSIFLDVLLVISAPLARNLAKRIGKNGTARMAVAMAIGLECGIVLTVPGVGALALAGLLGVPLGKMLLFGVCLVIPTVAISVAIMSFLFNRGWWDADRDEQPFLGDEPTTDEAGDTDADATGGVAVKTTTTPRTQTPLLVLFAPMLAALVLIATGAILDAAEIHNPIVKFVSSPVIALLIGLVGTSFVGRHALGAEPIQKAIATGFKESGQILILTGVGGSLAATIKAAGLGDILGEYFTASTAAPLLVVWAIAAALHIAVGSVTISAITSAGILAPVAPIIGLDPVLIALAAGAGSLFAVHVTSNTFWLLQSLMGQSTRGALKTVTVGVSVASVVAILLILPASLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PET8</accession>
    <name>A0A132PET8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_28890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043371284.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20737">
        <property type="protein sequence ID" value="KWX20737"/>
        <property type="gene ID" value="AFM11_28890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3658"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="420" mass="46730" checksum="3D445056C37C4722" modified="2016-06-08" version="1">MSETLESMAIDVDQRQLAEQLLAQAKERGIELVGPNGLLNQLTKNVLETALDAEMAEHLGYDKHDPAGRGSGNSRNGSRSKTVFTEIGPVEIEVPRDTNSTFDPVIVKKRQRRLTGVDEIVLSLTAKGLTTGEIAAHFDDVYGATVSKDTISKITDKVIEEMTEWCNRPLESVYPVVFIDAIFVKVRDGQVSNRPVYVAIGVTCAGERDILGLWAGDGGEGAKFWLSVLTEIKNRGTGDVCIVVCDGLKGLPDAINTVWPRAVVQTCVIHLLRNTFRYASRKYWDQIAKDIRPVYTAATEAAAKERFSEFTAKWGAQYPAITQLWQNAWSEFVPFLDYDIEIRRVICSTNAVESLNARYRRAIRARGHFPTEQAAMKCLYLVTRSLDPTGRGKARWAMRWKPALNAFAITFNGRITPTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEV0</accession>
    <name>A0A132PEV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856350.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20851">
        <property type="protein sequence ID" value="KWX20851"/>
        <property type="gene ID" value="AFM11_28495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3577"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="89" mass="9596" checksum="AF641B6501B754FF" modified="2016-06-08" version="1">MENSVSNILDAISDEARAVIEEELAQRNPTLLHSLQAAERPTNEQSDAVIDALSAALSENFGPGHIPNERGMAIDNAVGAYLLAWPIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFR7</accession>
    <name>A0A132PFR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854856.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21175">
        <property type="protein sequence ID" value="KWX21175"/>
        <property type="gene ID" value="AFM11_26325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3132"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453051" evidence="1">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="97" mass="9972" checksum="BB81E0D1130CB5DB" modified="2016-06-08" version="1">MQKTAEGLGVATIAASGLAAAIIGLAAPSHAAPAGPDNAQQTISQLQRQGYVVIVNRLGSAPLDQATVVAIRPGQNYSRTDTLNSSVTQRTVYVDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFW1</accession>
    <name>A0A132PFW1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose alpha-D-glucosyltransferase</fullName>
            <ecNumber evidence="3">5.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Maltose alpha-D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_26245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-maltose = alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:15145"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="EC" id="5.4.99.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. TreS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854818.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23355"/>
    <dbReference type="EnsemblBacteria" id="KWX21164">
        <property type="protein sequence ID" value="KWX21164"/>
        <property type="gene ID" value="AFM11_26245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3116"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047471">
        <property type="term" value="F:maltose alpha-D-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012810">
        <property type="entry name" value="TreS/a-amylase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02456">
        <property type="entry name" value="treS_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="42"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="590" mass="67904" checksum="9286FC7A84C7A54B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFY3</accession>
    <name>A0A132PFY3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855698.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10295"/>
    <dbReference type="EnsemblBacteria" id="KWX20892">
        <property type="protein sequence ID" value="KWX20892"/>
        <property type="gene ID" value="AFM11_27765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3426"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="217"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="321" mass="34887" checksum="3DD43C60053B82E7" modified="2016-06-08" version="1">MVDRTAHRVAALVSPLQGPFELACVTEVFGVQRDTDPPRYELTVCTERPGVVATPVGYAMTISAGLGALDTADTIVIAGWRRLDAPLSADVRRALTRAHERGCRIATICTGTFALAQTGLLDDRPATTHWAKAAELQERFPRIKVDPDVLYVDDGDVATSAGAGAGIDLCLHLIRKDHGAAYAAHVARHLVMPPHREGGQAQYAAPRTVATPPPSLAELLDWVSGRLDEPITLEDMANHLHVSSRTLARRFVEQLGTSPGQWLLTQRINAARALLEETDLPVDTIAIRVGLSSATNLRRRFQSAVHTTPGAYRRAFRHQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGT8</accession>
    <name>A0A132PGT8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853970.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26975"/>
    <dbReference type="EnsemblBacteria" id="KWX21427">
        <property type="protein sequence ID" value="KWX21427"/>
        <property type="gene ID" value="AFM11_24720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2305"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="158" mass="17384" checksum="051AAF6230EBBFDD" modified="2016-06-08" version="1">MPSDDLLRFVGGPLPFSLWWLWFGLLLIALVIAWCVGVYVWTMSPARLRTIPVIGSLHGKLVRQRFARTVRRTNEQFLAGGLSPQQAGANVSRTLRSFLFVATGVRAQYLHAGDIATGELAAAGPLLHALNDVQFNRGARADMVALGRSAEELIRSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGU9</accession>
    <name>A0A132PGU9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26595</name>
        <name evidence="2" type="ORF">AWC31_22740</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855002.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22740"/>
    <dbReference type="EnsemblBacteria" id="KWX21222">
        <property type="protein sequence ID" value="KWX21222"/>
        <property type="gene ID" value="AFM11_26595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15409">
        <property type="protein sequence ID" value="ORX15409"/>
        <property type="gene ID" value="AWC31_22740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3189"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX15409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="177" mass="18419" checksum="4700E9385081CAE0" modified="2016-06-08" version="1">MDTGSGRAIEIAPFHSGGTLKGFVVSGRWPDSTKEWAQLLMVTVRIASLPGLLSTTTIFGVREELPDQPQPGTVGLVMAEGPVVGEEAVPPGYFADHQPPALLMLHPPSETTPSLPECTGAASGCVLLPGLPHLGLEHRAAWVEAESDGTVTSMVSRVGVDPISHPDTAILAMLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH52</accession>
    <name>A0A132PH52_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853671.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23845"/>
    <dbReference type="EnsemblBacteria" id="KWX21643">
        <property type="protein sequence ID" value="KWX21643"/>
        <property type="gene ID" value="AFM11_24270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2213"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="321" mass="34274" checksum="D5ED74329511A0AF" modified="2016-06-08" version="1">MELIWWIVVIVGCVALAGCVVHALLWPHPVDRQRLRPLANTRRLTRLPEYLRAVRVRTITACLSIALLVTAFAAAVLVTARPMGLPSATQNSEALAPEDIMVCVGAPVSEPAVAATMRYFAQRVTSFGAERIGLTSANRRVVPLTRDYQYAAGQFGAYAQPVEQQDGEPFVAPVSYVDYAENVEDVLALCLTGFPTFDEKTPQRRSLIYVGPQSLPGPGGAQLFTDERVREMAAAAGVQVNVLATDTGGGPLDELARSTGGRSFEAGATVDGQLDDIRDHPPSAASSGDNATRSVETPDVGLVVALLAVVALSLWPVVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHG9</accession>
    <name>A0A132PHG9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2Fe-2S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_24865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854047.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27120"/>
    <dbReference type="EnsemblBacteria" id="KWX21452">
        <property type="protein sequence ID" value="KWX21452"/>
        <property type="gene ID" value="AFM11_24865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2334"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045612">
        <property type="entry name" value="DUF5914"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19299">
        <property type="entry name" value="DUF5914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="55"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="358" mass="39302" checksum="0410CFEF1AEE1090" modified="2016-06-08" version="1">MTTVSDLRSRLTKAWPFEVLPRLQWATQRPTHADASPAVIQAALARSQRRPSGNWYVFGASTHVTRKPVGTNVAGTELVAWRDDVETLHVGPAECPHLGADLSTGRVECGALICPWHGLRLTGRRQAGWKPYPSFDDGVLVWVRLDHTGGEAPTDEPVIVHRPGKPTVAAVARLTGTCEPADVIANRLDPWHGSWFHPYSFTKLDVLHSPPAAGDLPEERDRLTVAVTFRMGRLGVPVIAEFVSPEPRTILMRIVDGEGSGSVVETHATPVGLGPDGLPRTAVVEAVIAHSDRNGFRYATRAAPMLTPFMRYTATRLWRDDLAYAERLFEIRRRRMLSSPGRQGLPAQATEPVRPPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHK2</accession>
    <name>A0A132PHK2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">AFM11_23530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853229.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28255"/>
    <dbReference type="EnsemblBacteria" id="KWX21820">
        <property type="protein sequence ID" value="KWX21820"/>
        <property type="gene ID" value="AFM11_23530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2061"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="161"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="174"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="227"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="161"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="392" mass="41140" checksum="9A36B0C3E93120D4" modified="2016-06-08" version="1">MAQREWVEKDFYKELGVSSDASADEIKKAYRKLASELHPDRNSDPGAAERFKAVSEANSVLSDPAKRKEYDETRRLFAGGGFGRRFNTGGNFGGGGGFSSDGAEFNLGDLFDAAGQAGGANIGDLFGGLFGRGAQARPSRPRRGNDLETETELSFLEATKGVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPNCNGSGVINRNQGAFGFSEPCTECRGSGSIIEHPCAECQGTGVTTRTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKVFGRDGDDLTVSVPVSFHELALGTTLSVPTLEGKVGVRVPKGTSDGRILRVRGRGVPKRSGGHGDLLVTVKVAVPPNLEGEAAEALEAYAKAERASGFDPRAGWAGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHW4</accession>
    <name>A0A132PHW4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_23660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853304.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21844">
        <property type="protein sequence ID" value="KWX21844"/>
        <property type="gene ID" value="AFM11_23660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2088"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="116" mass="12194" checksum="99E9CEBEA1728F03" modified="2016-06-08" version="1">MSPDGRDRGLQPERTQLAWTRTSLAVLANGGLLLLKDPTAHESQDRIRLPVAMLVAVTAAGIYLIGIRRQRQLAARPLPAPTAARAVIVGVGVAMLILTCVVGAWAASAAFTVSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHZ1</accession>
    <name>A0A132PHZ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852780.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08590"/>
    <dbReference type="EnsemblBacteria" id="KWX21955">
        <property type="protein sequence ID" value="KWX21955"/>
        <property type="gene ID" value="AFM11_22615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1873"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="120"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="458" mass="50633" checksum="FE72B5DFE72BC2C5" modified="2016-06-08" version="1">MSTAPALDLDRFEELAAAGEITTVVCAAPDPYGRLVGKRLTIPAFRSLGLDGSGINASSFIFAVDLEMNPLDLPVSNAANGWVDIRLVPDLSTLRRVPWEPTAALVICDAYHMDSDQPLAVAPRTILRAQLERAAQHGMSFKFASELEFYLAATPPREAWELGYQNLKMLSDYRSDYQMIQAARDDWFIERIRNQMPEFGVPIESSKPEWGLGQQEVTLDYCDTLEMADRHVLFKYGVKQLANAADLTVTFMAKPKIDEVGSSCHLHVSMWSDDSGESLCWSPEHHGMSERFGSFVAGQLHHAADISLMFAPTINSYKRFQPDQFAGTAIALGNDNRSCAFRLVGTGPAFRVENRIPGADVNPYYAYAATIAAGLDGIERGLPAPDIFDGNAWTGSGVTTVPTALHRSLDLFAESKMARTAFGDEVFEHLLASAQSELEAFDSHTVTDWESRRYYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIF3</accession>
    <name>A0A132PIF3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_21465</name>
        <name evidence="6" type="ORF">AWC31_04280</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852341.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04280"/>
    <dbReference type="EnsemblBacteria" id="KWX22083">
        <property type="protein sequence ID" value="KWX22083"/>
        <property type="gene ID" value="AFM11_21465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10524">
        <property type="protein sequence ID" value="ORX10524"/>
        <property type="gene ID" value="AWC31_04280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1641"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX10524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="183" mass="20362" checksum="DC2BCEAE856950B7" modified="2016-06-08" version="1">MPDVSSADDENTTRERILVATAEVLGSNGMTKLSLSEVASQAGVSRPTLYRWFASKQDLLDAFVVWERSYFEQAVAKASAGLPAAERLDAALRITAEYQRSYPGLRMVDIEPEQVIRRLAQIIPLMRERLERLSSGPDASLAAATAVRVAISHYLVRGDDDEDFLAQLRHAARVRNRSYPREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIG4</accession>
    <name>A0A132PIG4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852361.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04345"/>
    <dbReference type="EnsemblBacteria" id="KWX22093">
        <property type="protein sequence ID" value="KWX22093"/>
        <property type="gene ID" value="AFM11_21530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1654"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="123"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="235" mass="25505" checksum="54D48EA866A2654C" modified="2016-06-08" version="1">MSLVAGRGPFSTQPAGWSVPPVSGPVVYIEPHPRRVQAVAGDVVKLDTEHALLVHRAGHPLSYAFPRGEVGELPNEPVAEAPGYVSVPWDAVEVWVEEGRKLVHYPPNPYHRIDCRPTRRGLRVSAAGAVLVDTDDTIILFETALEPRLYVNPALVRTDLLHRTDTTTYCNYKGTATYWSAVVGDTVISDVAWSYADPPSEALPIRGYLSFDAARVDVLAELPAPGATPACGCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PII6</accession>
    <name>A0A132PII6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="6" type="ORF">AFM11_21415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852322.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04230"/>
    <dbReference type="EnsemblBacteria" id="KWX22074">
        <property type="protein sequence ID" value="KWX22074"/>
        <property type="gene ID" value="AFM11_21415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1631"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="185" mass="20840" checksum="A8BBF50FD206A075" modified="2016-06-08" version="1">MIDETLFDAEEKMEKAVTVARDDLASIRTGRANPGMFSRINIDYYGAMTPITQLASINVPEARMVVIKPYEASQLRNIEDAIRNSDLGVNPSNDGNIIRVAIPQLTEERRRDLVKQAKSKGEDAKVSVRNIRRKAMEELSRIKKDGEAGEDEVGRAEKELDKSTHTYTNQIDELVKHKEGELLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIJ9</accession>
    <name>A0A132PIJ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852529.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04865"/>
    <dbReference type="EnsemblBacteria" id="KWX22179">
        <property type="protein sequence ID" value="KWX22179"/>
        <property type="gene ID" value="AFM11_22060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1760"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="14"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="320" mass="37318" checksum="5D47952E103BF331" modified="2016-06-08" version="1">MVTDQESRDRQPVLWAISDLHTGHTGNKPVTESLYPASPDDWLIVAGDVGERTDEIRWALDLLRKRFAKVIWVPGNHELWTTNKDPMQIFGRARYDYLVDMCDQMGVITPEHPFPVWTEQGGPATIVPMFLLYDYSFLPEGASTKAEGLAIARERNVVGTDEFLLSCEPYATRDAWCRDRVDQTRKRLEDLDWMTPTVLVNHFPLVREPCDAMFYPEFSLWCGTTATADWHTRYNAICSVYGHLHIPRTTWYDDVRFEEVSVGYPREWRRRKPYRWLRQILPDPKYAPGYLNEFGGHFEITPEMRANAKAMQDRIKARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIQ0</accession>
    <name>A0A132PIQ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852601.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22215">
        <property type="protein sequence ID" value="KWX22215"/>
        <property type="gene ID" value="AFM11_21560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1660"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="390" mass="41965" checksum="654DB0D84A12A8DA" modified="2016-06-08" version="1">MSRREFRSLTDNPVVTLAPDRLPPREQERTPEFGDHPGKWAVIYPAITVLVALTTLFGVGDAWHISVDRPATPAPRADSGPTSKSLNLNARRDSMIREIEARFGPAAANNLLDLRFTGSGSDYGTVLDPTNGDATIVYVNNSGDAFTTPSAQVLRKDSTFTAGDIAATDLIAITDKMAAQLDSAGRRSDLETLEIKRSSPGAPVILTGTFGSKTVDALPDGTVGEIFDPADFAVSFQRARDALALAGFAPSDRVVTNFEIRGTHRATPTAHASELQSSGGVLLEFQKDDRSGQIVIVPGELPEVTDDGPHRSPSQTFAFDDISQEVFEAVRAQAMQRGALEPYEREAVEIWMTDREIDEHRLAIRIELAGVEAATGTYSVTGEFLAPAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIZ7</accession>
    <name>A0A132PIZ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_20780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852075.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06195"/>
    <dbReference type="EnsemblBacteria" id="KWX22273">
        <property type="protein sequence ID" value="KWX22273"/>
        <property type="gene ID" value="AFM11_20780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1495"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026954">
        <property type="entry name" value="PknH-like_Extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038232">
        <property type="entry name" value="PknH-like_Extracell_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14032">
        <property type="entry name" value="PknH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="5">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PknH_C" evidence="6">
        <location>
            <begin position="109"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="314" mass="32977" checksum="31FB4B6AB3EBF9DA" modified="2016-06-08" version="1">MSFGGYGGPPPPHTFSAPPPAAPVNPLSTLSIVFGFVFAPVGAVLGHLALTQIKKRRERGRGRAVAGLTISYCVIVAAVVAVVVWAVLPGKSDDPVTSGTSAAESDKSAKQLLLTGSELGELLGETFEPVPQDAVEGGIDDMAETSSSQAGAEPYDCIGPVVVAERSGYADADVQDFARQVWRGSDGVVRKVDEAVIELSTPEDAQAVFDEIKATWQRCDGQTVTYWGTEIPDAGHLTHKITDIRTEETTLAATVLFGRTKKAQTSPNARAVTVAGSYLVETEISFDDEESTETANPETSGVDVAWAIADKIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ18</accession>
    <name>A0A132PJ18_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22358">
        <property type="protein sequence ID" value="KWX22358"/>
        <property type="gene ID" value="AFM11_20690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1475"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="169" mass="18215" checksum="EC0CDF8CD92AEC88" modified="2016-06-08" version="1">MAYGVFSVASEGKVRTAHSASDFSTVCEGDSLSNAADYREPYNIAAFYEGLGIVDTAWLPVEDNEWARSDDYSAINVVACLERKLGSDVKSTTCEGDDSGDTVTIDYYSVEYEIEFREAKTGKVIKSGDTVSGTAGDCPFLASYDKNSRKMYATPDADAVAAILRDFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJD4</accession>
    <name>A0A132PJD4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD_binding_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_20055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851892.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28460"/>
    <dbReference type="EnsemblBacteria" id="KWX22450">
        <property type="protein sequence ID" value="KWX22450"/>
        <property type="gene ID" value="AFM11_20055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1347"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="21"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="491" mass="51656" checksum="B8FF276E6740FDC5" modified="2016-06-08" version="1">MKEIPEVVGAAEVASWSDEVDVVVIGFGIAGGCAAVSAAAAGARVLVLERAAAAGGTTSMAGGHFYLGGGTAVQEATGHPDTPEEMYKYLVSVARDPDLDKIRAYCDGSVEHFNWLESLGFQFERSFYPGKVVVPPGTEGLSYTGNEKVWPFCEQAKPAPRGHSVPVPGELGGAAMVIDLLLKRADALGVEIRYEVGATNLVVENGSVVGVKWKHFGETGCVRAKSVVIAAGGFAMNAEMVAEYTPALGTKRRTKHHGEVEPYILGNPNDDGLGIRMGVSAGGVAKDLDQLFITAAAYPPEILLTGVIVNNQGQRFVAEDSYHSRTSAFVLEQADQEAYLIVDEAHMEMPAMPLIRFIDGYETIEEMETALGIPKGNLAATLQRYNANAAKGEDPDFHKQPEYVAVQDSGPWAAFDLSLGRAMYSGFTMGGLAVSIDGEVLRADGTAVPGLYAAGACASNIAQDGKGYASGTQLGEGSFFGRRAGAHAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJG1</accession>
    <name>A0A132PJG1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20175</name>
        <name evidence="4" type="ORF">AWC31_11540</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000036">
        <property type="protein sequence ID" value="ORX08756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851914.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11540"/>
    <dbReference type="EnsemblBacteria" id="KWX22471">
        <property type="protein sequence ID" value="KWX22471"/>
        <property type="gene ID" value="AFM11_20175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08756">
        <property type="protein sequence ID" value="ORX08756"/>
        <property type="gene ID" value="AWC31_11540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1370"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX08756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="171" mass="18314" checksum="A790B4C727849AC1" modified="2016-06-08" version="1">MAKLSAGLLLYRVVDDTVEVLLAHPGGPFWARKDDGAWSVPKGEYTDDEDPWAAAQREFGEELGAPPPAGPRRDLVPVRQAGGKVVTAFAVRADFDVTHARSNTFTLEWPKGSGKVREFPEIDRVAWLPVAVARTKMLAGQRPLLDQLMAAPDLAGCHEGGDADGAAAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJH7</accession>
    <name>A0A132PJH7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_20285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851934.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11430"/>
    <dbReference type="EnsemblBacteria" id="KWX22490">
        <property type="protein sequence ID" value="KWX22490"/>
        <property type="gene ID" value="AFM11_20285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1391"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="435" mass="45375" checksum="811786BB894C299F" modified="2016-06-08" version="1">MPSPQAMIQLDPSDAHGPRRAWAAVAVLALVGTLNYVDRFLPGVLAEPIKNDLALSDTAIGVINGFGFLIVYAVLGIVIARVADRGAFGAVIAGSLTLWGAMTVLGGAVQSGFQLALTRVGVAVGEAGSTPAAHAYVARNFPPERRSAPLAVITFAIPLASAASILGGGLLAENLGWRTAFVVMGAISVALAPLVLLVVGVRQTLPKPTVPEQDTKINWWDLLRKPSFLAIIGGTACISAAGYSLTTFAPAFLMRTRGMSLGEVGLEYGLATGLTGVLGLLIVGRLADRLAARDPRWLLMIVVVLTVMLLPASVLAFVVDNRALCVWFLALSYVIGTAYLAPSIAAVQRLVLPEHRATASAIFLFFNAVFGAVGPFLTGVISDALTADLGAQALGRALLILVPALQVVAMGCYFVAARRYRNDIIEVAESPSTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK04</accession>
    <name>A0A132PK04_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851729.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15510"/>
    <dbReference type="EnsemblBacteria" id="KWX22665">
        <property type="protein sequence ID" value="KWX22665"/>
        <property type="gene ID" value="AFM11_19425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1218"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="228" mass="23726" checksum="78FA45734C017F50" modified="2016-06-08" version="1">MTTPPTAVVTGASSGIGAATVRSLLDDGWHVVGVSRRDPSMEHGRFDWLAADLDDFGQLRDSLARVGPVDAVVHAAGLQRSSALGKLNVEDGLAMWRVHVAAAEVLVDALADRIRDGGRVVLVGSRTMTGNAGKSQYAATKSALVGMARSWAAELVGRQITVNVVAPGPTDTPMLNDPARRNTPPKLPPMGRFVRPDEVAGLIGFLLGPYGASITGQAIVQCAGVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK19</accession>
    <name>A0A132PK19_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_19510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851762.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15595"/>
    <dbReference type="EnsemblBacteria" id="KWX22681">
        <property type="protein sequence ID" value="KWX22681"/>
        <property type="gene ID" value="AFM11_19510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1235"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017536">
        <property type="entry name" value="Glutamine_synthetase_typeIII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03105">
        <property type="entry name" value="gln_synth_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="3">
        <location>
            <begin position="99"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="434" mass="46250" checksum="55C894404AF06BE4" modified="2016-06-08" version="1">MTLDLATLAEQSGTKFILALFVDLRGKPCAKLVPVEAIDMLATEGVGFAGYAVGAMGQEPKDPDLIAIPDPASFTPIPFIKEGLALVHCDPHVEGKPWPYAPRVILKGLIQQAADAGFEPWIGAEVEYFLLRRNADGSLATADTDDTAAQPCYDARGVTRMYDHLTAISTAMNQLGWSNYANDHEDGNGQFEQNFKFADALTTADRVITLRYLLSMIAAERGMVATFMPKPFSDRTGSGLHFHLSLTSGGNPVFPGETDERGLGLSETAYAFIGGVLDHACALQSVVAPTVNSYKRTGAVSTASGASWAPRKPSYGGNDRTHYIRVPDNQRIELRGGDGSANPYLAIAATLGAGFDGIKRSIDPGAVGSQGTTALPPTLLHAVDALETDPVVAGVLDVAGDGVATYFANIKREEFFTYHGAVTPWEIDSYLTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK38</accession>
    <name>A0A132PK38_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFM11_19700</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851825.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11040"/>
    <dbReference type="EnsemblBacteria" id="KWX22382">
        <property type="protein sequence ID" value="KWX22382"/>
        <property type="gene ID" value="AFM11_19700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1274"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="7"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="335"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="175"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KWX22382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="455" mass="47269" checksum="871A39566DE3761F" modified="2016-06-08" version="1">MTSTSADVVVLGGGPGGYATALRSAQLGLSVILIEEGGVGGTCLHRGCIPTKALLHAAEIADNARAAAQFGVNATFDGIDPEQLHAYKNSVVTRLHKGLQALLPAQGVTVVNGRGHLTGPNTVDVAGQTVTGGAIVLATGSAPKPLPGIETGDRVITSDEALELRSIPRRAVILGGGVIGVEFASLWASFGTAVTVVEAEPRLVPHEDETVSKHLERAFRRRKITAKTGARVTGVDQTDEGVTVTLENGAVIEADLVLVAVGRIPRTDGLDQAGITLERGFVVTDDRLRTTVPTVYAVGDIVAGTQLAHRAFQQGIFVADELTQRNPDPIDETGIPRVTYSRPEIASVGLTEAQARTRFGDNVETASHDLAGNGKSQILKTSGTVKLVLAPSGAVVGIHLVGERVGELIGEAQLIYNLQIKPGEAAKFVHAHPTQNEALGEALMAAAGMPLHGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKK4</accession>
    <name>A0A132PKK4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMNH2-utilizing monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_18465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851335.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12420"/>
    <dbReference type="EnsemblBacteria" id="KWX22879">
        <property type="protein sequence ID" value="KWX22879"/>
        <property type="gene ID" value="AFM11_18465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1027"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="387" mass="42637" checksum="000174864C86AF5D" modified="2016-06-08" version="1">MSESPPVHLGVALDGTGWHPASWREPDARPADLFKHDYWTDLVAEAERGLLDFATIEDGLTLQSDHPWRADDRTDRVRGRLDAVLIAARVAPRTNHIGLIPTAIVTHTEPFHLSKAIATLDYVSTGRAGIRVQVSARRDAAAHFGRRDIPERSPELSEELFGEAADYVEVLRRLWDSWEDDAEIRDVATGRFIDRNKLHYIDFEGAKFSVKGPSITPRPPQGQPIVAALGHVDHAYRLIASSADVGFITPHSADETAALVDEIGAARTGSEPVRVFADLVVFLDATPADASARRSRLDELAGSEYRSDAEIFAGTPQQLADLLQEWHAAGLTGFRLRPATLPHDLRQITEAVVPELQRRNVFRDAYGAPTLRGLLGLPRPANRYATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKQ2</accession>
    <name>A0A132PKQ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851319.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22873">
        <property type="protein sequence ID" value="KWX22873"/>
        <property type="gene ID" value="AFM11_18345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1016"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="164" mass="18660" checksum="F5B25BE3A873F50B" modified="2016-06-08" version="1">MRDFRHRANRQQTVAVYNADYRVLTHVSWQEAVRLLLRGSVYVIERHSPAVHIHSPSTSIELPVSVALREYVHVAYRPGNRVTRAGVLSRDRYTCAYCGGYGDTLDHVVPESRGGQNTWLNLVAACAPCNGRKDNRTPGEAGMRLLWEPYEPRERARYRVPAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKQ3</accession>
    <name>A0A132PKQ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851427.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22918">
        <property type="protein sequence ID" value="KWX22918"/>
        <property type="gene ID" value="AFM11_17845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.923"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="29939" checksum="04FC5589EB7C3494" modified="2016-06-08" version="1">MSLRNARVLVTGASRGLGRSIAEVVARRGADVALVARSGDSLEILAKELDGRAYPTDLCDRDAVEALIDRVEDDGPIDVLINNAGIDRVGRFPEASAQEVRDLLQVNLNAPMELCRQAMPRMLVRGRGHIVNVSSMGAISTGPGVTLYGASKAGLSHFTAGIRSELRGKPVGTTLVQIGEVKTDMIDHIRQFEPARRTIERSLKWGMLPREALEPDVVAEAIAAAVEHNRRHVILPRRIAAMAKFTEFPRRVSELMLTGIDQESDRAPKERNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLC6</accession>
    <name>A0A132PLC6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16605</name>
        <name evidence="3" type="ORF">AWC31_01175</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851006.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01175"/>
    <dbReference type="EnsemblBacteria" id="KWX23146">
        <property type="protein sequence ID" value="KWX23146"/>
        <property type="gene ID" value="AFM11_16605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13396">
        <property type="protein sequence ID" value="ORX13396"/>
        <property type="gene ID" value="AWC31_01175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.670"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="107" mass="12259" checksum="55B477210C490FEC" modified="2016-06-08" version="1">MPQLSGEQYLAVQASPEFQDLRSRLRRFVFPMSALFLVWYFAYVLLSVFATDFMATKVWGNINVGLLIGLGQFVSTFAITAIYVRFANRELDPRAEAFRHELEGMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLM6</accession>
    <name>A0A132PLM6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase III subunit delta'</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_15615</name>
        <name evidence="10" type="ORF">AWC31_16170</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850296.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16170"/>
    <dbReference type="EnsemblBacteria" id="KWX23246">
        <property type="protein sequence ID" value="KWX23246"/>
        <property type="gene ID" value="AFM11_15615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17945">
        <property type="protein sequence ID" value="ORX17945"/>
        <property type="gene ID" value="AWC31_16170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7245"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004622">
        <property type="entry name" value="DNA_pol_HolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015199">
        <property type="entry name" value="DNA_pol_III_delta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09115">
        <property type="entry name" value="DNApol3-delta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00678">
        <property type="entry name" value="holB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="39"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX17945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="403" mass="41889" checksum="CF4CBB0BE4123D94" modified="2016-06-08" version="1">MSGVFSRLVGQHAVEQELVAAAAAARGDSAHNGTATGTMTHAWLITGPPGSGRSVAALCFAAALQCTSDGVPGCGQCRACTTTMAGTHADVRRIVPEGLSIAVKEMREIVQIASRRPGTGRWQIVVIEDADRLTEGAANALLKVVEEPPPSTVFLLCAPSVDPEDIAITLRSRCRHVALTTPSVDAIADVLISGDGLPEEDARWAASVSGGHVGRARRLATDPEARERRKRALGLARDAATPSRAYAAAEEMVAVAEAEALALTAGRNETETEELKTALGAGGTGKGTAATMRGAAGALKELEKRQKSRQTRASRDALDRALIDLATYFRDALLVSSGASAVTANHPDMAEKVAALAAHAPPDKLLCCIEAVLECREALAVNVKPKFAVDAMVATVGQALRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLP8</accession>
    <name>A0A132PLP8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15760</name>
        <name evidence="2" type="ORF">AWC31_16005</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850346.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23271">
        <property type="protein sequence ID" value="KWX23271"/>
        <property type="gene ID" value="AFM11_15760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17916">
        <property type="protein sequence ID" value="ORX17916"/>
        <property type="gene ID" value="AWC31_16005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7275"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX17916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="83" mass="9321" checksum="46EABDD8F7770316" modified="2016-06-08" version="1">MSWLLVALIPGLLMLATFGLDRLEAGLARERTPARGVQRRPQPPPAVVQTLPADLDSDRLPTLRYVEHTINPEFRATRHANRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLX9</accession>
    <name>A0A132PLX9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_15670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850312.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23254">
        <property type="protein sequence ID" value="KWX23254"/>
        <property type="gene ID" value="AFM11_15670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7257"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="89"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="26672" checksum="DD5906B86C37CDDB" modified="2016-06-08" version="1">MTAAALALAAALLIWPAAPRRLSEMRRVQSRRLRAWPIGVVIGVGLALTGPVPIALAAGAVAGTATLRRRRSATRIRRERESTAMQAALDVLVGELRIGAHPVSAFGTAAGEVSGPVGEGMRAVAARARLGADVAAGLDDVAGESQLPMHWERLAACWRLAQAHGLSIATLMRTAQQDIVERERFSARVSAAMAGPRTTAAVLAGLPVVGIGLGQLIGADPIGFLLAPGVGGWLLVIGVLLACAGLLWSDRITDGAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM80</accession>
    <name>A0A132PM80_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849718.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09285"/>
    <dbReference type="EnsemblBacteria" id="KWX23425">
        <property type="protein sequence ID" value="KWX23425"/>
        <property type="gene ID" value="AFM11_14115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6927"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="2">
        <location>
            <begin position="135"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="269" mass="29237" checksum="CB0E9365D4C591A8" modified="2016-06-08" version="1">MTESNGASVQLGGVWNFRDVAAESGIRPGVLYRSSELSRLSDDGRAVFRRLGITDVADLRSHQEVNRRGPGQVPDGVAVHLLPFHPDDDSNQDAPHESTFQRVMSESPGDEDVTEAARRYMTEVYEEFPTLPGAHNAVRQVITLLAEGKPVIAHCFAGKDRTGFTVATVLATVGIDRDRVIADFLRSNDAIPALRTRIMDSVRARADDAPEVVTFAEARLTDEVLGVREDYLAAAWSKLDDAYGSVTGFVEAAGVSADEIEALRKTLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PML6</accession>
    <name>A0A132PML6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849970.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18045"/>
    <dbReference type="EnsemblBacteria" id="KWX23543">
        <property type="protein sequence ID" value="KWX23543"/>
        <property type="gene ID" value="AFM11_14855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7082"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="163" mass="17410" checksum="402F0AB0AEC9865F" modified="2016-06-08" version="1">MEYCLGDPDGSATMWTREPDVDLDNDGVFDGIGLDLDGDGRVDDVMADLDRDGLAEHAVRDIDDDGTAESYFTDDGSGVWAVSVDRSGQVRWFGLDGVEQTGGPTVDFDRDGATDDRLLDTDGDGLADRVLAGEFAHVDTDGDGRWDLKLADTDGDGRADSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMN1</accession>
    <name>A0A132PMN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850086.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23600">
        <property type="protein sequence ID" value="KWX23600"/>
        <property type="gene ID" value="AFM11_14585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7028"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="27177" checksum="0E5E0A7FA6309A4A" modified="2016-06-08" version="1">MTALFEDSGPRDRPVSRKEAARLLRQVSIGVGALLLAAVDDWNALSQRHFAHLRTTMHELGRGSYVATVTAASTDVWLSTRGMHPPGHIVSKPHRWPMISSHGKTYMAIHHNEMEPTNARRTAFCNQDSQTLALIDAETSDLINNPTHCEITWEYDQLTDTHVKGIWVSAPSVSWDRFGVPLARAQAQLTAWRKRNMKWLPGALPIDIDAAVLLPARDVQERLRPSIEVQPPQRSEDTRDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMN9</accession>
    <name>A0A132PMN9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849954.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18095"/>
    <dbReference type="EnsemblBacteria" id="KWX23534">
        <property type="protein sequence ID" value="KWX23534"/>
        <property type="gene ID" value="AFM11_14805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7072"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="248" mass="26562" checksum="99CDDA5BE2F56C24" modified="2016-06-08" version="1">MSAHITPLRLEGFEQLPKHARRCVFWEVDPSTVPGEDHLTDPEFEKEAWLSMVMLEWGSCGQLAVQTSPAAVGDFETLLKGDEPCVGYAFYAPPGAVPRARLFPTAPVSADAVLLTTVAVESAEETDGLSASLLAAVVSDLVRRGVRALEAFGYTTAVTDIDCGALPDELAPVVEVLGDCAVDQCMISADFLLDVGFTVVAPHPYFPRLRLELDKGLGWKAEVEAALERLLENARIELPVGAGSVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMT6</accession>
    <name>A0A132PMT6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_14965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850110.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17935"/>
    <dbReference type="EnsemblBacteria" id="KWX23613">
        <property type="protein sequence ID" value="KWX23613"/>
        <property type="gene ID" value="AFM11_14965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7104"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016570">
        <property type="entry name" value="UCP010361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010361">
        <property type="entry name" value="UCP010361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="540" mass="59494" checksum="4D60926AF2617B80" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMV3</accession>
    <name>A0A132PMV3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DO-GTPase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850076.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18445"/>
    <dbReference type="EnsemblBacteria" id="KWX23594">
        <property type="protein sequence ID" value="KWX23594"/>
        <property type="gene ID" value="AFM11_14375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6983"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045528">
        <property type="entry name" value="DO-GTPase2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19993">
        <property type="entry name" value="DO-GTPase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DO-GTPase2" evidence="1">
        <location>
            <begin position="96"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="385" mass="42047" checksum="86B89D5AA3CAC529" modified="2016-06-08" version="1">MSKCPRCFATLSPNQHLWTLPAQAGGTRYRDEVASAYTGAPADCGPLYTWSRSPGYNGPPPPTSEASRALQGPAVEICPVCHFTLPDGWREGHAICIALAGARATGKSLYIAVLVKQLELLCERFGFSMQPVTRGTAHAYATNYEAPLYVQRGLIPPTPTVHTQTSDHREPLMFSIGTWHGVRRYLVLRDVAGEDMESGDLHAPPFQFFAHADAVFFMFDPLRVKTIRDQLHDLLPAQVVSGGDPRTVLTNLLTAVRPGQPKLAVILSKFDVLRALREVEGSEWGLIMSNGGAAYLRDTSDGRQYDDVDGQLLHEEVRSLLIRLHGGSIVAAVENPATGIRLPSRNFVVSALGHPPNGNRLHARGIAPFRCVDPVRWVTSSFGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN21</accession>
    <name>A0A132PN21_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_13080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849214.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03365"/>
    <dbReference type="EnsemblBacteria" id="KWX23715">
        <property type="protein sequence ID" value="KWX23715"/>
        <property type="gene ID" value="AFM11_13080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6709"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019639">
        <property type="entry name" value="DUF2505"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10698">
        <property type="entry name" value="DUF2505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="168" mass="18144" checksum="6E755769E9D70CBC" modified="2016-06-08" version="1">MPRSFDMATEYDGSVEQVHRAFADERYWLARLADSGADDANLDRLTIADDGGIDVVTTQVLRSDRLPGLVSQFHQGDLSIRREETWQPIRDGQADGTVSGMIHGAPVSLTGTAVLAPSGAGAKLAVHITVEVKIPLVGGKIENFIGSQLVDLLIAEQRFTTVWISDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN55</accession>
    <name>A0A132PN55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849362.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03680"/>
    <dbReference type="EnsemblBacteria" id="KWX23766">
        <property type="protein sequence ID" value="KWX23766"/>
        <property type="gene ID" value="AFM11_13395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6773"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="338" mass="36834" checksum="9F5619E309B5561D" modified="2016-06-08" version="1">MAPPRKHETDVILDAARALVLADGPRAASVAAIAKVSGAPAGTLYHRFGNRNGILTAAWLRSLERFQSRAMAGASEPALESAVSMAVAAVRFARDVPDDARLLLTIRPADLLDGEPDADFQTRLAAMNAPLIERLRELARRIYGDDGPRTMDAMARAVVDLPYAVVRRHAHDAELPAWLEEDLADAVRKLLSVNTIVTASREIAAPAGAIFELIADPAQQPRWDGNDNLADAPAGQRVHAVGDVFTMNITQGSARENHVVEFEEGRRIAWRPSEPGAEPPGHLWRWELAPLDAGRTLVTHTYDWSQLTDEKRLVRARATTAEKLQASIDRLAAIAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNA1</accession>
    <name>A0A132PNA1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849098.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23677">
        <property type="protein sequence ID" value="KWX23677"/>
        <property type="gene ID" value="AFM11_12835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6660"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="36684" checksum="0B2DC268219AAE3B" modified="2016-06-08" version="1">MSRLTHSDVLVVDGLQINNWDRKVLEELVAGGVTGVNATCAVWDGPAETLRAVAQWYQLVASNDDIVTLAETCEQVREAKQDGRIAVLLGFQNSSPFGDDFRMVEIFHRLGVRVAQLTYNIQNLVGGACYDENDSGLTAFGRIIVGEMNRVGMLIDLSHVGNRTCLDAIEASATPVAITHSNPTWFVESPRNKPDEVINALAARGGVIGCCLYPNVLGGDSTTRAQFATMVARLVDQIGPDHVAIGSDCTRNWSEDYVGWLRNGRWRHPDHNPVEPTWPMWPDWFCGPADFPALTEGLQEVGLDDATIIKILGENWLRLFDEVFPGVEPTGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PND0</accession>
    <name>A0A132PND0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849541.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23846">
        <property type="protein sequence ID" value="KWX23846"/>
        <property type="gene ID" value="AFM11_13890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6874"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="183" mass="20369" checksum="92EDB2547C6B7DCE" modified="2016-06-08" version="1">MGKFVYVSGRHCLDFAGTILWRRTARTELLEHPEDLEQWARQAGVLADMQAPSPADVLTAREIREAIYRVVSAAVLKGPRPSQGDVDMINHEARQALPTLTLSRDGTTFSTGTFSNVTSLVARDTIDLIGSSDKAKVKECSNPDCTRLFVDHSRGFSRRWCGMAECGNRAKAADYRRRKKQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNI6</accession>
    <name>A0A132PNI6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849589.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03475"/>
    <dbReference type="EnsemblBacteria" id="KWX23875">
        <property type="protein sequence ID" value="KWX23875"/>
        <property type="gene ID" value="AFM11_13190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6731"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="256" mass="26765" checksum="B5629382A1B3BA1E" modified="2016-06-08" version="1">MAPPAAQLRELTVDIATRRGRDARAVRVLDEVDLVVEQGRVTALIGESGCGKSLVASALCGLLPPAARVSGRILVSGQDMTLAGESGWRPLRGRHVGFVPQSAATSFTPVRTIGSQLAEVCELLDSERTPGQLINAVGLAADVADRYPHELSGGMAQRMAIAAALSGRPRLLIADEPTSALDPDNAAMVWRLLADAAADGAGVLVVTHDLPSLLRAAACDDIALMRAGTVLRQAAAAELLDDADDYVRRFFAAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNS1</accession>
    <name>A0A132PNS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848250.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23980">
        <property type="protein sequence ID" value="KWX23980"/>
        <property type="gene ID" value="AFM11_11460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6368"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="408" mass="46320" checksum="2879F8051BA3DAF1" modified="2016-06-08" version="1">MTALKNDSATTTEVATDAPVTGDYLPWKDPQLRINPYPFYARALAEAPVSRDWDGTYVLTKYEDIMHYGRLPSVLIAPEWEKAGAWSVLKDMALGCDEPDHTRLKRITGKWLTPKQIKVWLGYTVEIVDEILDRVGDDGLVDGSALAVEALHRTICRVLQVPADEIEELRLQMRDAMFILSAMPDPQDFDLCVKGHEYMRRRTAELIDYKRANPGDGLLDELLRLQDLGEMTADEVFATTMFFWQVPHMDASYLASSGLHLFVRRPELFETFRAHPELHEAFVTELVRYDAPEPVITRATSEDLVIRGVHVPAGSSLRLVLGAANVDPDVFDNPLEFDYTRPPEQSRSLTFSFGSHSCQGKLMAQSQIRIIWERIAARYSRVELASEPVIKNTDASRHYYTLPLRLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNZ3</accession>
    <name>A0A132PNZ3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetolactate synthase</fullName>
            <ecNumber evidence="5">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_11535</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848291.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23994">
        <property type="protein sequence ID" value="KWX23994"/>
        <property type="gene ID" value="AFM11_11535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6383"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="188"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="398"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX23994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="550" mass="59079" checksum="1BBE49E448D2D58F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP99</accession>
    <name>A0A132PP99_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849566.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03120"/>
    <dbReference type="EnsemblBacteria" id="KWX23862">
        <property type="protein sequence ID" value="KWX23862"/>
        <property type="gene ID" value="AFM11_12800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6652"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="21880" checksum="5F4E95E0DC587DD8" modified="2016-06-08" version="1">MRHGEVHNPEKVLYGRLPDYHLSERGRAQAQATADWLADHDIVYVVASPLERAQETAAPIAEAHGLSIDTDDDLIESWNMFEGKRVSPGDGALRDPRNWPLLRNPSKPSWGEPYAEIAPRMMAALHRARLKAAGHEAVCVSHQLPVETLRRAMIGRKLAHLPLPHSRLCNLASVTSFTFDGDRLIRWGYTEPWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPT8</accession>
    <name>A0A132PPT8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylcrotonoyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847535.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18690"/>
    <dbReference type="EnsemblBacteria" id="KWX24351">
        <property type="protein sequence ID" value="KWX24351"/>
        <property type="gene ID" value="AFM11_10245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6087"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="265"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="513" mass="54819" checksum="65539E44DC9E7DF9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ31</accession>
    <name>A0A132PQ31_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847839.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19370"/>
    <dbReference type="EnsemblBacteria" id="KWX24448">
        <property type="protein sequence ID" value="KWX24448"/>
        <property type="gene ID" value="AFM11_10855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6210"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="105"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="388" mass="43214" checksum="DED4DC1FD22D2964" modified="2016-06-08" version="1">MSTATQTLYPPEGFGAPKNRRGHATGDLGLPEGTEIFSADNHISVADDIFYDRFPEELKGAAPRIWYEDGAYMVGMKGKAWTGGDFGRVLMQYDDLAGAASNNIEARIRELKEDGIDKELAFPNAVLALFHYPDKGLRERVFRIYNEHIAALQVQSGGHFYGVGLINWWDPKGARSTLDELKSLGLKTFLLPLNPGKDDDGNIYDYGSTAMDAVWDEIEASGIPVSHHIGETPPKTPCENNSVVVGMMVNVDSFREQFAKYVFSGILDRHPKLKIGWFEGGIAWVPTALQDAEHMLASYRHMFNHELQHDVRHYWDRHMAASFMVDPLGLRLIDDIGVDNVMWSSDYPHNESTFGYSEKSLATVVDAVGAENAVKIVSTNVQKFLGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQA0</accession>
    <name>A0A132PQA0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_10890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847990.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19405"/>
    <dbReference type="EnsemblBacteria" id="KWX24509">
        <property type="protein sequence ID" value="KWX24509"/>
        <property type="gene ID" value="AFM11_10890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6217"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="207" mass="22660" checksum="84E4B5F991F47126" modified="2016-06-08" version="1">MTTETAKRTRAEHLGPDRRRPQVLDAALEIAASDGVANVTMGAVAARLGVTRPVVYACYGGRGELLAALLERETEVTLANLLAMLPPERTGSVEQMFVDGFCALLTTVRERPSAWQIMFTVDLDPVLDAAIVRGRAQIGEQVAAVMRPLMQRWQVEDIDAVLPPLSEVFLAICESAIRMLLNDPDHWTPERLAAIVGPAAYRAMRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQB9</accession>
    <name>A0A132PQB9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_07530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845993.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22030"/>
    <dbReference type="EnsemblBacteria" id="KWX24530">
        <property type="protein sequence ID" value="KWX24530"/>
        <property type="gene ID" value="AFM11_07530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5354"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="382" mass="42977" checksum="B2A3DBF3D73C9D27" modified="2016-06-08" version="1">MDFDLGESANALRGELRELIREQVPADFLGAFTDDPADLAVAQQFCRTLAQRQLLCMSWPKEFGGGDASVWEQTVVREEMWAHHEPRGAQYMGVNWVGPIIMRHGTPEQQRKHLPPIANGEVIWCQGFSEPEAGSDLASLRTSARRDGDGWRINGQKIWTSYATMAQWCFLLARTSRGEKKQQGMTIFLVPMDDPAITVRPIRTMMGPHHLNEVFFDELQVTEADVLGTVDQGWSIVQDVVSFERVGIARYARCERLLQAAPDVLGEAWDELPAELRGRWARMLTHCRRARLMAYRVVAMQATGRVNPGDAAAYRIAVTRLDQESAEVLMEIAAVLPRGDGEYFRAEVEDHWRYSQASTVSSGSIEMQRILLSRTMLAGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRB0</accession>
    <name>A0A132PRB0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844983.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12800"/>
    <dbReference type="EnsemblBacteria" id="KWX24888">
        <property type="protein sequence ID" value="KWX24888"/>
        <property type="gene ID" value="AFM11_05425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4274"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453525" description="SBP_bac_5 domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="104"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="555" mass="57832" checksum="2D6332A624113E4E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRB2</accession>
    <name>A0A132PRB2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09130</name>
        <name evidence="2" type="ORF">AWC31_13240</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846804.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13240"/>
    <dbReference type="EnsemblBacteria" id="KWX24804">
        <property type="protein sequence ID" value="KWX24804"/>
        <property type="gene ID" value="AFM11_09130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18286">
        <property type="protein sequence ID" value="ORX18286"/>
        <property type="gene ID" value="AWC31_13240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5675"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="391" mass="41295" checksum="9E9A3341F7D358B9" modified="2016-06-08" version="1">MAQKAAVLGTGQTKYVAKRQDVSMNGLVREAIDRALADAGATMADIDAVVVGKAPDFFEGVMMPELFMADAVGATNKPLIRVHTAGSVGGSTAVVASSLVKSGKYRRVLTMAWEKQSESNAMWALSIPVPFTKPVGAGAGGYFAPHVRAYIRRSGAPNHIGAMVAVKDRLNGAKNPLAHLHQPDITLEKVMASQMLWDPIRFDETCPSSDGAAAMVIGDEQAADARVAEGHPVAWIHATALRTEPLAYSGRDQVNPQAGRDAAAALWRDAGITSPIDEIDVGEVYVPFSWFEPMWLENLGFAPEGEGWKLTEAGETAIGGRIPFNPSGGVLSSNPIGASGMIRFAESAIQVMGKAGDHQVPGARKALGHAYGGGSQYYSMWVVSSDKPGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRS6</accession>
    <name>A0A132PRS6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845233.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29470"/>
    <dbReference type="EnsemblBacteria" id="KWX25020">
        <property type="protein sequence ID" value="KWX25020"/>
        <property type="gene ID" value="AFM11_06205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4433"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="453" mass="46598" checksum="66C82A6DEAE7A2A7" modified="2016-06-08" version="1">MTVAATGRELTRLAGPIALTQLAQVALTTTDLVMMGPLGVAALAAGGLSITLFNQLRTMGVGLLTSVGNLVSAAASRSERDQTTAQASGDETRDLVRASFLVATVAGVVGGLALIGLGYLLRWLGQDAAVLDGTLPMLAALAPGLVPCLWFQVVRQFTVGMRRPKALLLITLASVALNVALNAALIYGPGPLPEMGLAGIGAATSLVYLLTFVAFTAMVRADPELAPYFSVAVHRAPLPAVKQILRLGIPIAGTYGSEAGLFSVTAVVIGTFGAPALAAHSVVNQLSYIVFQVSVGISHGASILVSRLVELGEAAQSRLIAWLAYGQGAAVAAVVALIYLAIPTEVLGLFMDTGDRAALVIAMALLAVAAFQQFVDSAQNIGIGLLRGLHDTSSSFVITIVGYWVVGFPVGLLLAYVADLEAVGMWLGLSAGLTTAAVLLLIVFRRRFAAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRV9</accession>
    <name>A0A132PRV9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_06115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29560"/>
    <dbReference type="EnsemblBacteria" id="KWX25004">
        <property type="protein sequence ID" value="KWX25004"/>
        <property type="gene ID" value="AFM11_06115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4415"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_haem-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="PTHR11220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="202" mass="22046" checksum="4158755977B43671" modified="2016-06-08" version="1">MLQQIPRLISRLIQAAPAVIGWRVGTEEPPYEAESLADGVEIRHYGPRIAAVTTIGADQDAALRLGFGRLAGYIFGDNGGASETGPVGGQKIAMTAPVAQTGGRGDKWDVQFYMPARLTIDTLPEPNDDRVRLAEIPAQSVAVLRFSGDRGPDAVAERTARLREVLREYGFEADGEATAWFYDPPWTVPFLRRNEIAIPVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRY2</accession>
    <name>A0A132PRY2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_06225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845236.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29450"/>
    <dbReference type="EnsemblBacteria" id="KWX25024">
        <property type="protein sequence ID" value="KWX25024"/>
        <property type="gene ID" value="AFM11_06225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4437"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="236"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="268"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="456" mass="47807" checksum="25D5873B96316C7B" modified="2016-06-08" version="1">MSVVAARALTITAASGRILAGPVDLDLEASTVTALIAPSGGGKSLVCRSLVGDLPAGTTLSGGPRVGDIEVAALDRRALRALRRNRIAYVGQDPGSALNPAATVTNLLTELAHPDAPSVTELLDMVQLDQRLATRRAVRLSGGQQRRVALARAMSRLTPVLVLDEPFAGLHQPLRDDIATLIRTWASDRRVAVLVTAHTTRTAATVADHVVELGAAAALAPVRDAPKRPPAGRDVLEVRRLTVTFGAHRVLDEAGLTLGAGSAVALMGDSGAGKSTFARALTGQVVADGGEIVLGGTSLAQPLHRRSRSDKMAIQLVPQDPAATLNPRRTVGATLNRALRSNGQRGAVADVLARVGLPDDFAQRYPHMLSGGQRQRVAIARALAYAPKVLVCDEITSALDPAAAATVMDVLEREMDRGLAVLMITHDAELAAGNCVRTVRLADGRLSTDEYDRESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSF9</accession>
    <name>A0A132PSF9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_03000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843802.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25279">
        <property type="protein sequence ID" value="KWX25279"/>
        <property type="gene ID" value="AFM11_03000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2468"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="218" mass="23908" checksum="E49568F232E7E765" modified="2016-06-08" version="1">MRVLVVEDERLLADAIASGLRRHSMAVDVVYDGAAALERATVNDYDVIVLDRDLPMVPGDEVCTSLAQSAILARILMLTAATAISDRVSGLGLGADDYLTKPFAFAELTARVQALARRSRPAVPPVLERSGIRLDPYRQTVDRDSHSVSLSRKEFAVLAELLRAEGGIVSAEQLLEKAWDEHIDPFTGVVRYTIMMLRRKLGEPPVIETEPGVGYRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSL8</accession>
    <name>A0A132PSL8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_07165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845646.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17550"/>
    <dbReference type="EnsemblBacteria" id="KWX25187">
        <property type="protein sequence ID" value="KWX25187"/>
        <property type="gene ID" value="AFM11_07165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4633"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="272" mass="29367" checksum="67AB2BF250862AA0" modified="2016-06-08" version="1">MTDAAAHFTQSDQDRYEPTRFAQSHWGEDHLNGPALVGLAAHALESAFGLPEFLPARLTVDLFKAARGVPTTTKVALIRDGRRVRNSECELVQDGVTVARATLVQYRRSSAPQGEEWVSDARFEPPAEVDGEPMTYMGSDANGWSRAIADHQNTSRKRFMNRTITVVEGQRNSPFVRAAMSAEGTSLVTNLGTHGVGYINGDLTVALSRLPLDEWVGVQADAHWTADGIAVGSSTLFDRAGAFGTGLVTAVSNPAAQIDFANDPFPDRTAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSP1</accession>
    <name>A0A132PSP1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5709 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843964.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25330">
        <property type="protein sequence ID" value="KWX25330"/>
        <property type="gene ID" value="AFM11_03330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2540"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043763">
        <property type="entry name" value="DUF5709"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18970">
        <property type="entry name" value="DUF5709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5709" evidence="2">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="131" mass="14256" checksum="269ADABEDA4DA191" modified="2016-06-08" version="1">MSSPEAPEERAGAYDIDDDDQLTQEDTLIDRGVDDLLDEGYSPPDRWKEPRENETLDEQLSEEEPDPAMEQDNPDEQAGDDEVGDDRAGRLVAPDDGTGEDDEAELLGREVGIDGGAASAEEAAVHVIDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSU9</accession>
    <name>A0A132PSU9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844018.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21720"/>
    <dbReference type="EnsemblBacteria" id="KWX25344">
        <property type="protein sequence ID" value="KWX25344"/>
        <property type="gene ID" value="AFM11_03430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2560"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="35"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="306" mass="34415" checksum="7D4EFDD03069CB5E" modified="2016-06-08" version="1">MSANPWRALDLDVLRRIDGLVPGDHEGSRLGLGSEREEVVRYQPGDDVRRIDWNITARSTDLHVWRPRADNQLDTWVLLDTTASMAFGTVADEKRELAAKIVAAIGLLTDAPGNRLGVATFGADGVRWHRPDSSRLAAHRLTRELAGDDRRTGSAITLAAAIDEFGRRRHRQGLRIVVSDFFDPAGGFDPPYDWYRPLRRLAARHDVIAIEVVDPREMALPDVGSVLLMDPESGRQRQIWTSNRTVRRRYEDAAAAYRASVSAAIRSSGAEHLPVSTGRDWVRDLARFIAARRRTMRRRSRGTRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSZ3</accession>
    <name>A0A132PSZ3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_03675</name>
        <name evidence="5" type="ORF">AWC31_21480</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844137.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21480"/>
    <dbReference type="EnsemblBacteria" id="KWX25384">
        <property type="protein sequence ID" value="KWX25384"/>
        <property type="gene ID" value="AFM11_03675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16595">
        <property type="protein sequence ID" value="ORX16595"/>
        <property type="gene ID" value="AWC31_21480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2610"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="474"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX16595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="664" mass="73672" checksum="0BCDFA8968CC945C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT02</accession>
    <name>A0A132PT02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844452.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20870"/>
    <dbReference type="EnsemblBacteria" id="KWX25476">
        <property type="protein sequence ID" value="KWX25476"/>
        <property type="gene ID" value="AFM11_04285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2735"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="184"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="530" mass="56105" checksum="B12F6C09921E57A7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT44</accession>
    <name>A0A132PT44_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844450.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20880"/>
    <dbReference type="EnsemblBacteria" id="KWX25475">
        <property type="protein sequence ID" value="KWX25475"/>
        <property type="gene ID" value="AFM11_04275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2733"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="28126" checksum="667FD81EA5B1171F" modified="2016-06-08" version="1">MVETRPLAMVTGASSGIGFELAKLLADDGYDLVVAADDGAIDASAEKLRAGGSGVRAVQVDLRNPEDVQRLYFAATDDGRSLDVAVLNAGVGRAGPFVEGDLDSDLSIVDLNVRSTVHLAKLVLRDMVARGSGKVLFTSSIAATMPGSLQTVYNASKSFIQSFSEALYDEMRDTGITVTSLMPGPTDTNFFRRGNMLDTVVGRMPKDDPAEVAKQGYEALLSGQRKVVAESVMTKAMGLANRVLPDSVKAVASRVISLPIDRIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTA7</accession>
    <name>A0A132PTA7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844602.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20430"/>
    <dbReference type="EnsemblBacteria" id="KWX25545">
        <property type="protein sequence ID" value="KWX25545"/>
        <property type="gene ID" value="AFM11_04715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2824"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="323"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="561" mass="62691" checksum="844EC8282CE5AE02" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU30</accession>
    <name>A0A132PU30_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-containing monooxygenase EthA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842378.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25848">
        <property type="protein sequence ID" value="KWX25848"/>
        <property type="gene ID" value="AFM11_00705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.144"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="501" mass="55525" checksum="A11C75A91DA57D17" modified="2016-06-08" version="1">MTTTTTSPRTQTSHFDVLVVGAGISGIGAGYHLKTHRPDTTFAILEGRDSIGGTWSLHQYPGIRSDSDMATFGYGFKPWTHRKAIADGHIILDYLQQTIDDFHLAEHIRFGYRVTGAEFDSQQGQWTVSATHTASGEATTFTSRFLFLATGYYDYENPFTPEFAGADDFGGQVIHPQHWPMDLDYAGKRIVVIGSGATAVTLIPSMAEKAGHITMLQRSPSYVLSIPAEDPIANALNKVMGHRRASKFVRRKNISLGRGIFKACERAPGLMRRLLIANVRRQLPKNFDVDTHFTPRYKPWEQRLCMVPNGDLFKAISAGKASVVTDRIERFTKTGILLESGQELAADIIVTATGLNMSPFGKIRLGVDGRHINLPDTTAYKAMMLSGVPNFAYAVGYTNLAWTLKVDLVCEHFCRLLDYMDANGHGTVVPTLDNPAMERVPLMDMTSGYVQRAIRKFPRAGTTGPWTLKHAYEFDVERLRHGPVEDAVLKFTPKKPALVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU46</accession>
    <name>A0A132PU46_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_00660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842356.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33770"/>
    <dbReference type="EnsemblBacteria" id="KWX25840">
        <property type="protein sequence ID" value="KWX25840"/>
        <property type="gene ID" value="AFM11_00660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.135"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="70"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="3">
        <location>
            <begin position="251"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="337" mass="36778" checksum="4E1001367F90523D" modified="2016-06-08" version="1">MPFLTDMYHDQNRNSAKVADPPAAAPTGGFDPEALSRRLNAAILGQQAAVEAVVRAVSIAHIGVADPGRPLSSVLLVGPTGVGKTELVRQVAAALRTGPDDLCRIDMSALAQEHYAASFSGAPPGYAGSKESFTLFDKAKIEGGPYMPGVVLFDEVEKADATVLRALLHVLDTGELRLANGQQKISFRNSYIFLTSNLGSLEVAAAQRSRRKQWWPKRRPAHRTMVREAVESFFDPEFFNRIDETVVFDAFDDDTAQQVARKEIGDLVMRLKSRGVELDVDDSVVELVRGHGFDPVYGARGLRRTIRHELTEPVARAVLTGQSSLRARVQDGELTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUA8</accession>
    <name>A0A132PUA8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25895">
        <property type="protein sequence ID" value="KWX25895"/>
        <property type="gene ID" value="AFM11_00975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.201"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="75" mass="7546" checksum="EA35002617C86E8B" modified="2016-06-08" version="1">MTVAPQVRGSIALGSHIPVALPGVQFDTMAAIRRPEPENHSPGVEVNAGKTVGVRLPAAAALACADDGRYGGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUS0</accession>
    <name>A0A132PUS0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843596.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34150"/>
    <dbReference type="EnsemblBacteria" id="KWX25917">
        <property type="protein sequence ID" value="KWX25917"/>
        <property type="gene ID" value="AFM11_01110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.228"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="280" mass="29259" checksum="10C9131C282DA259" modified="2016-06-08" version="1">MASTKKLFAALTRRGPHRVLRGDLAFAGVPGVVYTPESGLNLAGVAFAHDWMAKSDNYTKTLEHLASWGIVAAAPNTETGLAPSVLNLAFDLGAALDIVSGVRLGPGKISVHPTKRGLVGHGFGASAAVFAAAGMPNKPKAVAALFPTITKPPAEQPAARLQVPGLVLTDPGDPMTLRSNAVELARAWEGATLRTVDDIKAGGLMEGRRLARVLGLPSAHRGTQKIVRALLTGYLLATLAGDKTYKDFADPEVQLPHTQTPDPNADPVALEDKVVALLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUS4</accession>
    <name>A0A132PUS4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843107.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34950"/>
    <dbReference type="EnsemblBacteria" id="KWX26070">
        <property type="protein sequence ID" value="KWX26070"/>
        <property type="gene ID" value="AFM11_02170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="512" mass="55221" checksum="C09EDB9650B30F78" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUT9</accession>
    <name>A0A132PUT9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dihydroorotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_02400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843246.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35180"/>
    <dbReference type="EnsemblBacteria" id="KWX26111">
        <property type="protein sequence ID" value="KWX26111"/>
        <property type="gene ID" value="AFM11_02400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.492"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="55"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX26111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="456" mass="48881" checksum="2FB70FC077039C4A" modified="2016-06-08" version="1">MTAPITPDLVVTGGTVVSHDGRRRQDIAVSDGRVVAVGDDLTTEGVRTVDASGLLVLPGLVDVHVHLREPGMTEKEDFASGTSAAAAGGVTTVVDMPNTNPPVATAERYQHKLDLVKNRAYVDFGLYGMLDHDNADEIGAMAELGAMGFKLFMGQTTGDNRCPNDAAIFRGLEAAADADLVVGVHAENDHLLRMFGDRLQAQGRRDPRAHLEGRPAFVEVEAITRIITMATEAKTKLHIHHLSTAAGLGRVVDLRAQGHRVTIETLVSHLFLDESAYDAYGNLIKLNPPIRPAADVAALWAGIERGDVDVIATDHAPHTAAEQAETDVWKAYGGFIGVETMLPLMLTAAAQGRLTVEDIVRLCSYTPAKRWSMAGKGQLAPGFDADFLLVDPEAEVVLDQRDLHSKHNITPYDGWELTGSVVATYLRGGLVYEKGTVVGEPTGRQVRPQSASAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV21</accession>
    <name>A0A132PV21_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26208">
        <property type="protein sequence ID" value="KWX26208"/>
        <property type="gene ID" value="AFM11_00300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.61"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="487" mass="53142" checksum="A4FE102A09BC38ED" modified="2016-06-08" version="1">MEWYYELHPTYRLVIRWALIAGLTAFAFRASFGSLVTTTREGGIGGYVWTVPLVAALVAVGVARRNRTELPIHDRQTDIIVGTMGLGLALMIQAALLDRYALYFHLLRLDLVAAWLFVLCCCVILFGLRPVIRFTWVWALCALAFSLPYYLAVVLLGGGKFAAGAATLLIAAVGTGIAVGRTFRRGVLGSLGAWAVGFAVLIAIGTFFPDTPLLTYQQVPAVTAICVVGVAMYLTSRRGVRKRILDRKVEPLAAKQVWSGVPLVVAAAVALSLCALPTQTTTAPISRPSPVALSPGQPLVAPGGWSTIEREDFRQVHRFYGDNAVLVRQYMRADHGNPRWDKLSRPRTVVVDSIVSRRPFTFGVYPARVLYGLTGARLSAQRPVDLGMGVHGLMLSVVDDDLLVTWNSLQFAWGDSDLAQRVTVFAVDNHEPDAPFPTPSGSVVSNLRTLITLLFRGNAVLDERRPVFKDQELLTIFGRALVAAQFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVJ0</accession>
    <name>A0A132PVJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26294">
        <property type="protein sequence ID" value="KWX26294"/>
        <property type="gene ID" value="AFM11_02660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.546"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="109" mass="11758" checksum="B7863CE202D65C78" modified="2016-06-08" version="1">MEERQDQRPQRFRLSATWLLAFLTIPAAIAVFVYGMGAVMSMAGCADDACANQGPGEFWFGVLFYGAPVVPVVTIAVSIFTARLRYGILVPIAGLVLLAIDFAVLALTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVV6</accession>
    <name>A0A132PVV6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_02730</name>
        <name evidence="6" type="ORF">AWC31_35505</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843769.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35505"/>
    <dbReference type="EnsemblBacteria" id="KWX26297">
        <property type="protein sequence ID" value="KWX26297"/>
        <property type="gene ID" value="AFM11_02730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12147">
        <property type="protein sequence ID" value="ORX12147"/>
        <property type="gene ID" value="AWC31_35505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.562"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="31"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="168"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX12147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="295" mass="32861" checksum="8B48C73D1CA2E7C1" modified="2016-06-08" version="1">MPLPADPSPTLTDYAHPERLVTADWLASNLGRPGLAIVESDEDVLLYDTGHIPGAVKIDWHTDLNDPHVRDYINGEQFAELMDRKGIGRDDTVVIYGDKSNWWAAYALWVFTLFGHPDVRLLDGGRDLWVSHGRDTTLDVPTRQTSGYPVVERDDAPIRAFKEDVLGILGKQPLIDVRSPQEYTGERTHMPDYPEEGALRGGHIPTAKSIPWAKAAKDSGQFRSRAELEELYGFLKPDDKTVVYCRIGERSSHTWFVLTHLLGLPGVRNYDGSWTEWGNAVRVPVAVGPDPGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVV7</accession>
    <name>A0A132PVV7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PE-PPE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_02715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843408.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35490"/>
    <dbReference type="EnsemblBacteria" id="KWX26162">
        <property type="protein sequence ID" value="KWX26162"/>
        <property type="gene ID" value="AFM11_02715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.557"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013228">
        <property type="entry name" value="PE-PPE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08237">
        <property type="entry name" value="PE-PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453663" description="PE-PPE domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="PE-PPE" evidence="3">
        <location>
            <begin position="86"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="498" mass="54122" checksum="CC5699550FA803D8" modified="2016-06-08" version="1">MGKRSKVVRPIAISFAALSTAATVALYPTVHIESRLLARTLLVMPGNDNPNGDNLEYGLNNYFNPTDPNYGFPGYDMVKVSWMSDSFDDDPGYQVSQDDGVEKLDTAINKYLNVDDGEDDYIVAAGYSSSANVVIREMKHLDSLGEAAPSPDQIKFMVLGSPHRPNGGIFGRFPGFNLMGIPFEETNPDTQYELTDIGYEYDPISDFPAYPLMPLTLLNSLAGWQLLHISYGGVESDLDNAIDNPNMTYYDEEKGIRYITIAAPHLPLLMPAYMVADALPPLKPFIEPVLKLIEPTLKVLVDLGYNREVPVGEHLPAQLLPKHDPAKVAANLADAVAKGIADAVESITGVKPDAADGADDAEETDTEKADTEKTDAATTTEEEGTAVDTKPGSTAEPTTKPLAKVSERIRDRIDSVAADLGLDRDREKRATETESEDEPEANTKEVSKKETKKKESDAAKDSDDMPAKKQQGKSDKKSAKNSESAKDDSKDSDKADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PW37</accession>
    <name>A0A132PW37_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TsaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842633.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34220"/>
    <dbReference type="EnsemblBacteria" id="KWX26232">
        <property type="protein sequence ID" value="KWX26232"/>
        <property type="gene ID" value="AFM11_01180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.242"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="39"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="210" mass="21451" checksum="89DC89D034F4A17E" modified="2016-06-08" version="1">MTQLILTIDTATPAVSAGVVRRDDDGVVTTLAERVTVDARAHAEQLTPNVLGALSDAGVGVEDLDAVVVGCGPGPFTGLRVGMASAAAFGHALGVPVHGVCSLDAIGCHTTGDVLVVTDARRREVYWARYRDGVRVDGPAVNAPADVPADAAAVAGSPQHTALFELPVLDVVYPTPAGLVAAVADWGAPAPLVPLYLRRPDAKPSAAVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAN7</accession>
    <name>A0A132PAN7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_36025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000070">
        <property type="protein sequence ID" value="KWX19408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19408">
        <property type="protein sequence ID" value="KWX19408"/>
        <property type="gene ID" value="AFM11_36025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF222" evidence="1">
        <location>
            <begin position="4"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="229" mass="24535" checksum="45CE63C380807435" modified="2016-06-08" version="1" fragment="single">KGDQYLGLAKALVHEMPHTLAALEAGMLSEWRATLIVRESACLAVEDRRRLDAELCADPTRLQGWGNSRVKAEARKIAVRLDAAAVVERSAKAAADRGVWIRPAPDTMAYVTVLLPVDRAVAVYAACKNAADTTCDDRSRGQIMADTVYERVTGRPAPQPVPLALNLVMADTTLAGDDDAAAWLGDYGPVPAGFARTLTGDAVADAEVKATLRRLYRHPGSAQLLAMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAV2</accession>
    <name>A0A132PAV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000047">
        <property type="protein sequence ID" value="KWX19465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859929.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12700"/>
    <dbReference type="EnsemblBacteria" id="KWX19465">
        <property type="protein sequence ID" value="KWX19465"/>
        <property type="gene ID" value="AFM11_35740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5884"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="176"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="347" mass="37717" checksum="20DAE814E54A021D" modified="2016-06-08" version="1">MSAWIVITVLVVLLVVFLLIAGWAYQTANRLDRLHVRYDLSWQALDGALARRAVVARAVATDAYAGGPEGKRLAALADAAERAPRSAREAAENELSAALAGVDLAALPVALVAELADAEARVLLARRFHNDAVRDTLALRERTAVRMLRLGGRAALPTYFEIAERPEAQAGPNPVSRRTSARVVLLDETGAVLLLRGSDPAHNDPHNPAPRWWFTVGGAVQQGEDLPAAAARELFEETGLKVQPADLIGPVWRRDAVIDFNASVIRSEELFFIYRTHRFEPSASGRTALERHYIHGHRWCDATMIAELVAGGETVYPLQLGELLASANELAEQSLVNARGSALQAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB61</accession>
    <name>A0A132PB61_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859668.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19575">
        <property type="protein sequence ID" value="KWX19575"/>
        <property type="gene ID" value="AFM11_35155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5760"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="186" mass="19978" checksum="93B812E89F6A1108" modified="2016-06-08" version="1">MAKIESRSDVRRKVREAQTRAQQERLKRESDNREDMVAFLLAEQKLQAVDDWETEHVAQVRGEAEQRRHEQRVEGAKAVARMKARGETIKDIAALGGVSEKLVRSYLKLAAKTPAVREAAGVGSQALGSAGSAAAESGGRDAVVNGSRALGDRSSSASPDGDGDPGDCVQRSQEDTSHEAVLSANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBA7</accession>
    <name>A0A132PBA7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type VI secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VirD4/TraG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19584">
        <property type="protein sequence ID" value="KWX19584"/>
        <property type="gene ID" value="AFM11_35145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5757"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003688">
        <property type="entry name" value="TraG/VirD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02534">
        <property type="entry name" value="T4SS-DNA_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="454" mass="49222" checksum="870010321625F9EF" modified="2016-06-08" version="1">MLYTADGRPYMAESASHLLASAPTRTGKTRRILAPAAVVHPGPAVCCSSKPDLAELVMQRRFSGPVGVIDLRPTKAVVWPANIRELVTDPTGAITNGDDALTVAETMLATSGVGFGGAASGQTVAAGGLWETSAAPPLACLLYAASPLGNGKGMPWVLRAVATRGDDEDDDAHAGEVDYPSWAAAYALCPHADLREPLMELMTMDSRLRDSVTITMKKATTPWVRLGLTSKHSDPFRAADTISIDSFDVTMLDDPNATLFVIAPNNGTVAGAAVALIDSIVQYFRKKSDQHQLTQRLLLELDEVCNSCPLPSLLNYVGESAGLGVNIMATVQSTSHFDVVFGPKYADALRDMFPGTLIMYGSHERHFLEQASDWLGLATRRTEAYEPNSGSRGQSSVFGAQIDWQDFLPQNREEAHLLARGEPGQRVHIPDWEDFLQIWDRVVEQRVQKARRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBT0</accession>
    <name>A0A132PBT0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859152.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11375"/>
    <dbReference type="EnsemblBacteria" id="KWX19707">
        <property type="protein sequence ID" value="KWX19707"/>
        <property type="gene ID" value="AFM11_34240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5187"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007801">
        <property type="entry name" value="UPF0276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42194">
        <property type="entry name" value="PTHR42194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05114">
        <property type="entry name" value="DUF692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="31271" checksum="F6AA2947085BB8C7" modified="2016-06-08" version="1">MSSFSRAVPALGDVGIGWRREIAGVIADLRPGFCEVIAESIPVRRRKARPDPLLAGLAARGVPVIPHGVALSLGGAEPVQLKRIRRLAACAEALVAPVASEHIAFVRAGGIEAGHLLPVPRTREALDVLAANIERTRRELPVPLAVENIASFVEWPESDLTESEFLTELLERTGVLLVLDVANVYANARNRGRDPHQELARLPVERVAYSHVAGGHEDGRFYHDTHSDRTPREVLDLVAALRERVNTPFMLERDGRYPPTAELFDELDAIAAASGSAPITTAARAVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBT5</accession>
    <name>A0A132PBT5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_34055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859049.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02505"/>
    <dbReference type="EnsemblBacteria" id="KWX19778">
        <property type="protein sequence ID" value="KWX19778"/>
        <property type="gene ID" value="AFM11_34055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5148"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="329" mass="35264" checksum="19085B06BCA73827" modified="2016-06-08" version="1">MVAGVDFGDAAFAADVRDGVARIEDMMSEELGKADELMAEAVQHLFQAGGKRFRPLFTVLSAQLGPQPDAWQVTVAGSVIELVHLATLYHDDVMDEAQVRRGAPSANARWGNNIAILAGDYLFATASRLVSRLGPDAVRVIADTFAQLVTGQMRETRGAADHVDSIDHYLKVVYEKTACLIAASGRFGATFSGADDEQIERLSRLGGIVGTAFQISDDIIDIDSDPDESGKVPGTDLREGVHTLPVLYALRETGPEADRLRELLAGPVERDEDVAEALSLLRGSPGMARAKETVASYAAQAREELANLPEGPGRHALASLVDYTVNRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCC2</accession>
    <name>A0A132PCC2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858251.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32065"/>
    <dbReference type="EnsemblBacteria" id="KWX19973">
        <property type="protein sequence ID" value="KWX19973"/>
        <property type="gene ID" value="AFM11_32690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4865"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017685">
        <property type="entry name" value="ArgP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03298">
        <property type="entry name" value="argP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="31865" checksum="4AC7D9E826A1357A" modified="2016-06-08" version="1">MQIDGQQLAAFAAVIELGSFDAAAQRLHVTPSAVSQRIKALEQRVGQVLVVREKPCTATPAGVPLLRLAAQTALLESETLTEMSGGSAHRTRIALAVNADSMATWFTGVFGQLPEVLFDIRIEDQDFSARLLREGVVMGAVTTERTAVTGCRVYPLGAMRYVPVASVEYVERHFPDGFTRDAAARAPSLAWNRDDTLQDQLVRKAFRRDIARPTHFIPTAEGFGAAVKTGLGWGMYPEELIDESFVPVTPHHLDVPLFWQCWKLDSPTVTAITDAVRSAARNLRLTGGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCK2</accession>
    <name>A0A132PCK2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19712">
        <property type="protein sequence ID" value="KWX19712"/>
        <property type="gene ID" value="AFM11_34275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5197"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="101" mass="10894" checksum="6A3B1AA11F5D6A60" modified="2016-06-08" version="1">MDISVVDGFVGKLLDIGADRGILYSYSGFTNGATARAIGNAAPRVMLVALATPENVVQNGGTPGYPADLLVQELAPQWVEELDAESFSRFLTDGQWSKWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCM5</accession>
    <name>A0A132PCM5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858263.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32090"/>
    <dbReference type="EnsemblBacteria" id="KWX19977">
        <property type="protein sequence ID" value="KWX19977"/>
        <property type="gene ID" value="AFM11_32715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4872"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="385" mass="40094" checksum="DC8ECB357CA8F784" modified="2016-06-08" version="1">MVTDIALPRFARIGAGAIDELGSVVAQLGILRPMLVTDKYLSETGQAERLVKTLHAAGIEAAVFSETVPDPTVASLSGGLDLVKAHNADGIIGFGGGSPMDTAKALAVLSANGGSIASYKAPSSYTGPALPIVAVPTTAGSGSEATQFTVITDGETDEKMLCPGLSFLPIAIVVDFELTVSMPARLTADTGVDALTHAIEAYVSRRASPFSDALALAAMRSISQHLRRAYADGADRQAREAMMLASTQAGMAFSNSSVALVHGMSRPIGGHFHVAHGLSNAMLLPAITKFSIESAVDRYADCAKAMGLVAESAASAYAAGALVAELEQLCRDVEVPTPQSYGVDKDDWEARLELMAEQALASGSPGNNPRVPTKDEIVELYRKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCN2</accession>
    <name>A0A132PCN2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="3">GMPMT</shortName>
            <ecNumber evidence="3">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgE</name>
        <name evidence="5" type="ORF">AFM11_32625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858176.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19760"/>
    <dbReference type="EnsemblBacteria" id="KWX20101">
        <property type="protein sequence ID" value="KWX20101"/>
        <property type="gene ID" value="AFM11_32625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4853"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="223"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="3">
        <location>
            <begin position="548"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="692" mass="77069" checksum="AA8EC8E8A070A4A0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCR4</accession>
    <name>A0A132PCR4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glutaminase</fullName>
            <ecNumber evidence="3 5">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glsA</name>
        <name evidence="7" type="ORF">AFM11_32670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3 5"/>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858246.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19805"/>
    <dbReference type="EnsemblBacteria" id="KWX20128">
        <property type="protein sequence ID" value="KWX20128"/>
        <property type="gene ID" value="AFM11_32670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4862"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="315"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="427" mass="45544" checksum="51E2011617D1A8AA" modified="2016-06-08" version="1">MADLVQRYLDQIRAEHVALREGALADYIPELATVDPDGFGVTLSSSDGFVYESGDTAVEFTIQSISKPFTYALALDQIGERAVDARIGVEPSGEAFNEISVDKTTKTPKNPMINAGAIAAVSLVPGATPDERFNRIHEFYSACAGRRLDVDLDVYASEKATGNRNRAIAYMLTSFGALQGDPDEVLDVYFRQCSIKVTSTDLARMAATLARGGLNPLTGRRVTDGQVVRRTLSVMVTCGMYDAAGDWVSAVGMPAKSGVGGGIAAVLPGQLGIGVYSPRLDAKGNSVRGVAVCRSLSTRLGLHFLTVSRETSATLRAVYDAGPRIRVYEIQGDLLFAGAEQVLRTAARESAGFDVAILDGTRVDDINDTARDMLTGMRAGLAEDGKEGYLVDPDGRVVPAERRGDYDAVVFRTVDDAVAAARQLLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCS6</accession>
    <name>A0A132PCS6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secretion protein EccC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_33015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858409.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32460"/>
    <dbReference type="EnsemblBacteria" id="KWX20027">
        <property type="protein sequence ID" value="KWX20027"/>
        <property type="gene ID" value="AFM11_33015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4934"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="454"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="812"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="477"/>
            <end position="484"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="830"/>
            <end position="837"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1327" mass="145049" checksum="8C2FEFA051397F81" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCT0</accession>
    <name>A0A132PCT0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858185.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19785"/>
    <dbReference type="EnsemblBacteria" id="KWX20104">
        <property type="protein sequence ID" value="KWX20104"/>
        <property type="gene ID" value="AFM11_32650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4858"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="158" mass="17196" checksum="D3DD6D0232EFA444" modified="2016-06-08" version="1">MTTEHVDARPALASALVTAIDHVGIAVPDLDVAIKWYHDHLGMIVLHEEVNEEQGVREAMLSVRGAPKGSAQIQLMSPLDETSTIAKFIDKRGPGLQQLAYRTSDIDALSERLRADGVRLLYDAPRKGTANSRINFIHPKDTGGVLVELVEPAADSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCY1</accession>
    <name>A0A132PCY1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857935.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20198">
        <property type="protein sequence ID" value="KWX20198"/>
        <property type="gene ID" value="AFM11_32190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4765"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="21297" checksum="B166E6E33B4E429E" modified="2016-06-08" version="1">MQSENADAATKPAAAESDLGARIREFRLARKLTLRDLATRAATSPGFLSQLERGQVNASVGTLRRLCEELGVTLPDLFTDHHANGARILRKRDRPEIHVSDTSAKYLLSQKPLRNLEVYVAEFAPGGTAGEAYVHDDSQEILLVIAGSIVLELDGVMHHLEAGDSAEYRTSVPHTVHNQSTEPAELLWIVSPPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD31</accession>
    <name>A0A132PD31_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="3" type="ORF">AFM11_32660</name>
        <name evidence="4" type="ORF">AWC31_19795</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX17112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858243.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19795"/>
    <dbReference type="EnsemblBacteria" id="KWX20127">
        <property type="protein sequence ID" value="KWX20127"/>
        <property type="gene ID" value="AFM11_32660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17112">
        <property type="protein sequence ID" value="ORX17112"/>
        <property type="gene ID" value="AWC31_19795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4860"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX17112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="224" mass="25020" checksum="CE0915C75EEEAA9C" modified="2016-06-08" version="1">MRLVIAQCTVDYVGRLTAHLPSARRLLLFKADGSVSVHADDRAYKPLNWMSPPCWVTEQETDAGDPLWVVENKTGEQLRITVEDVEHDSSHELGVDPGLVKDGVEAHLQALLAEHVELLGAGYTLVRREYPTAIGPVDLLCRDELGRSVAVEIKRRGEIDGVEQLTRYLELLNRDTVLAPVAGVFAAQQIKPQARTLATDRGIRCVTLDYDQMRGMDSDEYRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD92</accession>
    <name>A0A132PD92_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31590</name>
        <name evidence="4" type="ORF">AWC31_26205</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX15088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26205"/>
    <dbReference type="EnsemblBacteria" id="KWX20311">
        <property type="protein sequence ID" value="KWX20311"/>
        <property type="gene ID" value="AFM11_31590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15088">
        <property type="protein sequence ID" value="ORX15088"/>
        <property type="gene ID" value="AWC31_26205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4222"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="191"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="333"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX15088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="599" mass="64836" checksum="2E95374F6E729B0E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDE0</accession>
    <name>A0A132PDE0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857128.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26505"/>
    <dbReference type="EnsemblBacteria" id="KWX20340">
        <property type="protein sequence ID" value="KWX20340"/>
        <property type="gene ID" value="AFM11_30785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4058"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="489" mass="52953" checksum="1EFE790DA9FB1F7C" modified="2016-06-08" version="1">MIDVIIAGAGPTGLMLGCELRLHGVNVVVLERDTEPTKVVRSLGLHARSIEVMDQRGLLERFLAVGRQHPLGGFFAAIRKPAPQRLDTAHAYVLGIPQTISDRLLTERAVELGVDIRRGHELVGLSQDEHGVRVEVAGPGALDGATLRARYLVGCDGGRSTVRKLLGIGFPGEPATVETLIGAVEVGMSPETLGAVVAEARKTQIRFGAMPLDDGAYRIVVPADGLAEDRSAAPTLDEFKRQLRATAGTDLGVHSPRWLSRFGDATRLADRYRVGRVLLAGDAAHVHPPAGGQGLNLGIQDAFNLGWKLAAEINGWAPSGLLDTYEVERRPVAADVLENTRAQMTLMSLDPGAQAVRRLVAELMDFDEVNRHLTEKIIATAIRYDFGDGHDLLGRRLRDIRLHRGRLYEHMHTGRGLLLDQAGRLSVAGWGDRVDRVADGSDELAEPAVLLRPDGHVAWVGDDQQDLRRALVRWFGVSDAHSVRAVNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDQ6</accession>
    <name>A0A132PDQ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856860.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20471">
        <property type="protein sequence ID" value="KWX20471"/>
        <property type="gene ID" value="AFM11_30320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3961"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="284" mass="31600" checksum="9A052A59B89E5D0C" modified="2016-06-08" version="1">MGPDDFFEETETFSPWSSEPTITTKLRKDFLNELRAGAVAGTDDLDAAIALTHLVWDDLIAFGTGGGNTLDDKELTLAQRALIATLSRIGITLGIPWRDFSTFKAHWLRNGCSGSWQARRDLLNELFAPVQAELDRQEEAQFRAVNAEAVSPHTKTGWPKVDEELTELRRRFRTATTTQDYRDVGNRAVGVLEALSRTVYDPAVHLRDGETEPPTDKTKQRLGRYVEDSLAGKDNEAIRGVANKVIELAHSVKHSTAPTRREAGIAADSVIMLANILRRVDQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDR4</accession>
    <name>A0A132PDR4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856877.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20476">
        <property type="protein sequence ID" value="KWX20476"/>
        <property type="gene ID" value="AFM11_30345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3967"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="163" mass="17059" checksum="8825D367C31CAEDD" modified="2016-06-08" version="1">MSRVQLALNVDDLDEAITFYTKLFGVSPAKVKPGYANFAVTEPPLKLVLLENPGKGGTINHLGVEVESGEKVHAEIARLTGEGLFTDEEIGTTCCFATQDKVWVTGPAGEKWEVYTVLADSETFGTSPQLLDGGEADQGGGVCCGGTAAAEAEPETAKTTSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDZ0</accession>
    <name>A0A132PDZ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24920"/>
    <dbReference type="EnsemblBacteria" id="KWX20556">
        <property type="protein sequence ID" value="KWX20556"/>
        <property type="gene ID" value="AFM11_29580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3807"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031702">
        <property type="entry name" value="DUF5078"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16877">
        <property type="entry name" value="DUF5078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452988" evidence="1">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="146" mass="16638" checksum="503B6880310FFBE1" modified="2016-06-08" version="1">MGKRLIAGLAAVVALSAVPGVASADATDDYPIPNRILKTPCTAEQIMAAARDVEPVYYERYMIDYNNKPAADQQGARDRIHWFFSLDYAGRRQYSENTATNAFYESMAWRWPNWAKLFFNNKGVAANTTDICQQYPPDDMSVWNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE21</accession>
    <name>A0A132PE21_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856505.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25020"/>
    <dbReference type="EnsemblBacteria" id="KWX20575">
        <property type="protein sequence ID" value="KWX20575"/>
        <property type="gene ID" value="AFM11_29680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3828"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="26763" checksum="F3DE7049E83BB8EF" modified="2016-06-08" version="1">MAADPRLSVRRVAVIRPLVAVIGRRAVQVPILRFSATLAAEAICEAVWAAGGEPVVLHGPAADPMAELPGRLAAFDGVLLPGGADIEPGRYGQEPADETHDTVAFQDDFDLGVTRAVIELDMPTLAICRGMQVLNVALGGSLTQHVRETNTLHHNAIHDVEVVTGSRLHAIVGCESIAVSSYHHQALDRLGTDLTVTAVAADGIVEAVEHRRSDIVAVQWHPEDRHATSDTDAALFADLVDRARKRKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEE2</accession>
    <name>A0A132PEE2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleic-acid-binding protein containing a Zn-ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040647.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20709">
        <property type="protein sequence ID" value="KWX20709"/>
        <property type="gene ID" value="AFM11_29275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3741"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="54"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="134" mass="14829" checksum="6090859400EB01CF" modified="2016-06-08" version="1">MTTPPVPALTASTAVYWQEAAAGRFVLPRCRACGRFHHHPRRWCPYCWGTDLTWEQPSGRGTVLTYTVVYQPPSPAFAVPYVLAVIELSEGPRMMANVVDCSPEDVEVGTPVEVTFEPRGELAIPQFRPIGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEM5</accession>
    <name>A0A132PEM5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_28410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856105.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20771">
        <property type="protein sequence ID" value="KWX20771"/>
        <property type="gene ID" value="AFM11_28410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3560"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="37"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="191"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="392" mass="41292" checksum="F43E3B569857CACA" modified="2016-06-08" version="1">MNAPSIFHLQTDRAAQRGSSDSLTVGLLSTYPPTTCGLATFSAALTGALAAHGTDVRILRIADGSPAASGFVAGELINGSAASVARCSDLLNESDIAIVQHEYGIYGGADGSEVIDIIGGLDIPCLVVVHTVLKAPTPHQRSVLERIAELADRIVVMSESANRQLCLGFDIDRRKVITIPHGATIPNHAPVKRGGRPTLLTWGLLGPGKGIERVIDAMGTLHRLNGRPRYVVAGLTHPKVLAADGEAYREACIERARRIGLANSVAFDPGYRDVSSLSALARSAAVVVLPYDSTEQVTSGVLVDAVANGRPVVATAFPHAVELLSSGAGIVVDHDDPDALTRALRRVLTQPRLAGAMAAEARRLSPAMAWSVVADAYQTAAHRILSERMKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PER1</accession>
    <name>A0A132PER1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856277.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33025"/>
    <dbReference type="EnsemblBacteria" id="KWX20826">
        <property type="protein sequence ID" value="KWX20826"/>
        <property type="gene ID" value="AFM11_28795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3637"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="200" mass="22255" checksum="8B57171AFE26380D" modified="2016-06-08" version="1">MPGMPPPAADERQTLLEFLAFQQNAFFAVAHGLTDEQARATPSVSTLSVGGLVKHAAGVQKGWADRAAHAPAAPPPDPRPMEEQMAEYADQYVMREDETLAGLLEALKAQNAETLRVFAEQDLDAAVPVPHGVPWFPQDIDNWSVRWVAMHLIEELSRHAGHADIIRESIDRATMYELMAAEEQWPETDWIKRWRPAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEX2</accession>
    <name>A0A132PEX2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856401.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24825"/>
    <dbReference type="EnsemblBacteria" id="KWX20542">
        <property type="protein sequence ID" value="KWX20542"/>
        <property type="gene ID" value="AFM11_29485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3788"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="98"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="444" mass="48309" checksum="68F30C65CEB6ED46" modified="2016-06-08" version="1">MDDGLVSDIKRGSVARNAKLASLPVGMAGRAALGFGKRLTGKSKDEVTAELMDKAAQQLFTVLGELKGGAMKVGQALSVMEAAIPEQYGKPYREALTKLQKDAPPLPAAKVHRVLDAQLGTKWRDRFTSFDDTPVASASIGQVHKGVWSDGREVAVKIQYPGADEALRADLKTIQRLVGVFKQLAPGADIQGVVDELIERTEMELDYRLEADNQRAFAKAYRNDPHFAVPAVIASAPKVVIAEWMDGIPMSVIIREGTPEQRDLMGTRLTELTFGAPARLDMMHGDAHPGNFMLLPDGRMGVIDFGAVAPLPGGFPPSLGLTIRLARDKDYDQLIPVMEGAGFIQKGQQVSVQEVDDMLRQYVEPIEVDVFHYTRRWIQRMAAGQMDNSVAQIKMARQLDLPPNLAIPLRVIASTIAICCQLDAHVPVKAIATELVPGFAEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF13</accession>
    <name>A0A132PF13_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855785.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10500"/>
    <dbReference type="EnsemblBacteria" id="KWX20925">
        <property type="protein sequence ID" value="KWX20925"/>
        <property type="gene ID" value="AFM11_27980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3470"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453006" evidence="1">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="83" mass="8079" checksum="E78FB917FCCDD237" modified="2016-06-08" version="1">MANALRRGMLTMVSVAVLAAAPMGVATIATPAVSAACLPGETGVTNGCAPFCLPGKQLDTATGLCLPVPPPPPAPNGNATPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF49</accession>
    <name>A0A132PF49_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplJ</name>
        <name evidence="9" type="ORF">AFM11_28855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856311.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33085"/>
    <dbReference type="EnsemblBacteria" id="KWX20837">
        <property type="protein sequence ID" value="KWX20837"/>
        <property type="gene ID" value="AFM11_28855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3649"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="175" mass="18120" checksum="E1C54AE544B6DB0B" modified="2016-06-08" version="1">MAQAEKATAVADIAEKFKEATATVVTEYRGLTVSNLAELRRSLGDGATYTVAKNTLVKRAAAEAGIEGLDDLFSGPTAIAFINGEPVDAAKAIKKFAKDNKALVVKGGYMDGKALSVAEVDRIADLESREVLLSKLAGALKAKQSQAAALFVAPASQVARLAAALQEKKAGENAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFL6</accession>
    <name>A0A132PFL6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855460.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07355"/>
    <dbReference type="EnsemblBacteria" id="KWX21103">
        <property type="protein sequence ID" value="KWX21103"/>
        <property type="gene ID" value="AFM11_27420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3358"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017822">
        <property type="entry name" value="Carotene_biosyn-assoc_mem-1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03459">
        <property type="entry name" value="crt_membr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="509" mass="54480" checksum="54B51BBFAD36607D" modified="2016-06-08" version="1">MTPTGIQTPNSGLAQHVSRFGAFAVSAEARPARLGCLGAALLTIGGLGAGSTRLHDPLLESLHLSWLRFGHGLVLSSILLWTGVALMLIAWLWLGRRVIDRTATEYTMVATTGFWLAPLLLSVPLFSRDTYSYLAQGALLRDGFDPYVVGPVENPNSLLDNVSPIWTTTTAPYGPAFILVAKFVTILVGNDVVAGTMLLRLCMLPGLVLLIWATQRVARHIGASGAAALWVCVLNPLVIIHLMGGVHNEMLMVGLMMAGIALTFERHPVWGIGLIAVAVAVKATAGLALPFMVWAWMHQLRDRRDLPAVRAFALATAASIVIFAAVFAVMSLLAGVGLGWLSALAAGNVKIINWLTVPTAVANLINVFGGLVLPVNFYAVLGVTRIVGIAIIAVSLPLLWWRFRHSDRDLLTGIALAMLVVVLFVPAALPWYYTWPLAVAAALIQTRPAIAAIAAASTWIMVMWKPDGAHGMYSWAHVLLTTACAAVAWYSLSRAPEPASEPEPEPSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFN9</accession>
    <name>A0A132PFN9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21150">
        <property type="protein sequence ID" value="KWX21150"/>
        <property type="gene ID" value="AFM11_27550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3384"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="119" mass="12866" checksum="0BD98BACD4BE4FB4" modified="2016-06-08" version="1" fragment="single">MFESLFDIDPGASEQQLRALVEKYELLKPALAAAQARATALWDAKRRAREAADGVPAAKRGKGLAAEVALARREAPKKGDQYLGLAKALVHEMPHTLAALEAGMLSEWRATLIVRESAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFU9</accession>
    <name>A0A132PFU9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854887.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22945"/>
    <dbReference type="EnsemblBacteria" id="KWX21183">
        <property type="protein sequence ID" value="KWX21183"/>
        <property type="gene ID" value="AFM11_26370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3142"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="447" mass="50187" checksum="EB318EB3C154F729" modified="2016-06-08" version="1">MTETVPVLETSTRASRIPPGPQLPRLVQGVAFSAARRWVVKQVSRRYGDVFTLHVPVFGRTVIVAEPQLAKQLFQANTDDVGNIQPNLSRILGSGSVFALDGSDHRSRRKLLTPPFHGKSIKNYETIFEEETLRESATWPEGQEFETLEPMMRITLNAILRAVFGADGEQLDELRRIIPPWVTLGSRLAVLPTPKRTYGRFSPWGRLAAYRRQYDDVIDRLIDRVEADPDFDRRDDILALLLRSAYEDGSTMSRKDIGDELLTLLAAGHETTASTLGWAFERISRHPQVLARLVAEAATDGNEYRQATILEVQRARTVIDFAGRHVYAPSFELGEWVIPRGYSIIVAISQIQERHEEFPDPDRFDPERFVGSRPGLGWIPFGGGTRRCVGAAFANIEMDVVLRTVLRHFIIETTTEPDEKVHSRGVAYTPAAGGRVVVRRRAEPLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFV9</accession>
    <name>A0A132PFV9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyprenol-phosphate-mannose-dependent alpha-(1,2)-phosphatidylinositol mannoside mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_27390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855440.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07325"/>
    <dbReference type="EnsemblBacteria" id="KWX21097">
        <property type="protein sequence ID" value="KWX21097"/>
        <property type="gene ID" value="AFM11_27390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3352"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="429" mass="46888" checksum="347CABBD08CA1E79" modified="2016-06-08" version="1">MSKRQSPGGAGWAGWAPSIAWRIFQLLTLAALVWVGWRLLGRVPYRIDIDVYRMGGQAWLDGRPLYADGAIFHTQGGLDLPFTYPPLAAIAFAPFAWLSLPVASSAITVTTLVLLIVSTVIVLTRLDVWPHTSITAEPAWMRRCWLAAAVVAPAVIYLEPIRSNFEFGQINVVLMTLVIADCVPRRTPWPRGLLLGLAIALKLTPAVFLLYFLLRRDVHTLLRTAASAVIATLAGFVLAWRDSLEYWTETVRNTDRIGTATLNTNQNIAGALARLGLGEGPRFALWVVACFAVLALTVWAARRALRSAADESSVLALICVAMFGLVVSPVSWSHHWVWTLPTLLVAGILAYRHRNALLAAVTAAGVALMVWTPITLMPEHRETTASLWRQLAGGSYVWWALATIMAIGFASTSQARDRAAVAAEPLVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG63</accession>
    <name>A0A132PG63_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26240</name>
        <name evidence="2" type="ORF">AWC31_23360</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855121.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23360"/>
    <dbReference type="EnsemblBacteria" id="KWX21264">
        <property type="protein sequence ID" value="KWX21264"/>
        <property type="gene ID" value="AFM11_26240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15710">
        <property type="protein sequence ID" value="ORX15710"/>
        <property type="gene ID" value="AWC31_23360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3115"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX15710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="129" mass="13448" checksum="2D85C80B8B49D59A" modified="2016-06-08" version="1">MYTAAIDALPHVGDAEFPERAAVVLSGLRKLQASLSEAAGRSRVTPSVIVALSGVRSRYDDLMVTAAEGPGATLGQRLYVARMRAKLTTAEAANGIGVRQDLIEAVEAEEPATESETAQIKELIAALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG65</accession>
    <name>A0A132PG65_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_25780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854521.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36115"/>
    <dbReference type="EnsemblBacteria" id="KWX21336">
        <property type="protein sequence ID" value="KWX21336"/>
        <property type="gene ID" value="AFM11_25780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3020"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="36"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="163" mass="16428" checksum="593CF073688B4EEB" modified="2016-06-08" version="1">MARAATPAIAALLAAGIDHEVVSYHHDPRNDSFGAEAVAQLAADGIVAEQVFKTLVIALPKGLAVAVLPVPTKLSLKAAAAALGVPKAEMADPAAAQRSTGYVVGGISPLGQRKPLPTVVDASALHFDKVLCSAGKRGWDVALAPADLIRATSAVTAEIGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGM8</accession>
    <name>A0A132PGM8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="5" type="ORF">AFM11_25035</name>
        <name evidence="6" type="ORF">AWC31_27290</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854126.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27290"/>
    <dbReference type="EnsemblBacteria" id="KWX21481">
        <property type="protein sequence ID" value="KWX21481"/>
        <property type="gene ID" value="AFM11_25035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14859">
        <property type="protein sequence ID" value="ORX14859"/>
        <property type="gene ID" value="AWC31_27290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2368"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX14859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="64" mass="6865" checksum="89D90FBB4C8E825F" modified="2016-06-08" version="1">MAAVCDICGKAPGFGKSVSHSHRRTSRRWDPNIQSVRAVTRPGGNKQRVNVCTSCIKAGKVARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGR6</accession>
    <name>A0A132PGR6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional uridylyltransferase/uridylyl-removing enzyme</fullName>
            <shortName evidence="7">UTase/UR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bifunctional [protein-PII] modification enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Bifunctional nitrogen sensor protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII] uridylyltransferase</fullName>
                <shortName evidence="7">PII uridylyltransferase</shortName>
                <shortName evidence="7">UTase</shortName>
                <ecNumber evidence="7">2.7.7.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII]-UMP uridylyl-removing enzyme</fullName>
                <shortName evidence="7">UR</shortName>
                <ecNumber evidence="7">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnD</name>
        <name evidence="10" type="ORF">AFM11_25165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13673"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
            <dbReference type="EC" id="2.7.7.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:48600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GlnD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.59" evidence="7"/>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854185.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27485"/>
    <dbReference type="EnsemblBacteria" id="KWX21503">
        <property type="protein sequence ID" value="KWX21503"/>
        <property type="gene ID" value="AFM11_25165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2394"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01693">
        <property type="entry name" value="UTase_glnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="9">
        <location>
            <begin position="442"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="623"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="743"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uridylyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="819" mass="87848" checksum="4E7053FBBB1EC0EF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH02</accession>
    <name>A0A132PH02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853657.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23870"/>
    <dbReference type="EnsemblBacteria" id="KWX21638">
        <property type="protein sequence ID" value="KWX21638"/>
        <property type="gene ID" value="AFM11_24245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2208"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="167"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="391" mass="42297" checksum="7E3D4B5CC97B28F4" modified="2016-06-08" version="1">MFIVVLATILGLMHFYIWVRVIKNTTSPGRARRLLTTLFLALAVLLFATLILPRVIGLTESAWFAWPGYVWFALAAYLFLTLLVLEPVRLALRGWVRRAPEPPAAPAVEDPQPAVNRRLFLARASAVAAGVASAGLVGAGMASALGPPDLLRVPVRLRRLDPAFNGFRIAVVSDIHLGPLAGRAHTERIVEMINETAPDLVAIVGDLVDGTVEELGSAAEPLRDLVSRDGTFFVTGNHEYFVDDTTAWLRELDRLGIHTLRNENTLIRRGSAGFDLVGVNDVAGESIAEPPDFDRALDGTDRARPTVLLAHQPVQVAEAADRGVDLQLSGHTHGGQMWPFHYVVQAVQPSLAGLSNFGDTQLYVSRGAGFWGPPVRVGAPPDISVLTLQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH53</accession>
    <name>A0A132PH53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_24335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853698.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23780"/>
    <dbReference type="EnsemblBacteria" id="KWX21651">
        <property type="protein sequence ID" value="KWX21651"/>
        <property type="gene ID" value="AFM11_24335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2226"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="362"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="451" mass="49462" checksum="F12991E1209660DD" modified="2016-06-08" version="1">MRHIRVAVIGAGPAGIYAADIVTKEYEHARVDVFDRLPAPYGLVRYGVAPDHPRIKEIIKALRRVLSRDEIRFIGNVHYGTDIRLADLRRHYDAVIFSTGARGDRALDIPGIELPGSYGAADFVSWYDGHPDVPRTWPLTAKNVAVLGAGNVALDIARMLAKPADEQLTTEIPGNVYHGLAANAATDVHVFARRGPAQIKFSPMEFRELSHSPSVDVIVHPEGFEIDEASQQAINTSKSTKLVVDTMMKYLEREPTGAPHRIHIHLCQAPVAVLGTDRVEGLRTERTELKGDGNVRGTGEFTDWPVEAVYRAVGYLSSHLAELPFDHHAGVVPHDAGRVIDIDGGLVDATYVTGWIKRGPIGLIGHTKSDAAETVNSLLTDLPGLRVPEVGDPDAILSHLSDNGVDYTTWAEWERLDSHEMSLGEVQGRERVKVVAREEMIQAGRDALVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHD1</accession>
    <name>A0A132PHD1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24485</name>
        <name evidence="4" type="ORF">AWC31_23635</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853933.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23635"/>
    <dbReference type="EnsemblBacteria" id="KWX21736">
        <property type="protein sequence ID" value="KWX21736"/>
        <property type="gene ID" value="AFM11_24485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15719">
        <property type="protein sequence ID" value="ORX15719"/>
        <property type="gene ID" value="AWC31_23635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2258"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032407">
        <property type="entry name" value="MHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038378">
        <property type="entry name" value="MHB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16525">
        <property type="entry name" value="MHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04529">
        <property type="entry name" value="MTB_hemophore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453286" description="MHB domain-containing protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="MHB" evidence="2">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX15719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="132" mass="13168" checksum="7E3B64B92D15BDEE" modified="2016-06-08" version="1">MKFTGITARRGIAGACASGLLGGVAAAMIAAPAANAAPDCSASGLANTVSSATGAARAYLDTHPGANQAVTTAMTQPRPQAAATLRGYFTANPAEYYDLRGILAPIGDAQRACNVTALSPELSSAYDEFMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI19</accession>
    <name>A0A132PI19_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22895</name>
        <name evidence="3" type="ORF">AWC31_08305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852881.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08305"/>
    <dbReference type="EnsemblBacteria" id="KWX22008">
        <property type="protein sequence ID" value="KWX22008"/>
        <property type="gene ID" value="AFM11_22895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10162">
        <property type="protein sequence ID" value="ORX10162"/>
        <property type="gene ID" value="AWC31_08305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1932"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="151"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="330" mass="35839" checksum="F2DFDDCD17529EB9" modified="2016-06-08" version="1">MAVSKVERLMNLVIALLSTRTFLPAEKIRTSVAGYADSPSDEAFSRMFERDKNELRDLGIPLETGRVSKFDPTEGYRINRDSYALPPVQLTADEAAAVAVATQLWQSPELVTATQGALLKLRAAGVDVDADDAGVAIASTATLPGLRGSEEVLRILLSAIDSGRAVQFEHRPMRSAEYTTRNVEPWGIVTHRGRWYLVGHDRDRNDTRTFRLSRIDSGVRPVGPSGVVSKPDGVNLREIVSRVVAEMPTGEQAKVWIAGGRATALRRQAVATAPRTLGGRAGEEITVDLGMSDRLAREIASYGADAVALEPQSLRDEVVARLRAQAGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI56</accession>
    <name>A0A132PI56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_22860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852869.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08340"/>
    <dbReference type="EnsemblBacteria" id="KWX22001">
        <property type="protein sequence ID" value="KWX22001"/>
        <property type="gene ID" value="AFM11_22860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1925"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="154"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="375" mass="39381" checksum="5584ED94D99D5394" modified="2016-06-08" version="1">MTISRFSTDVYAQRLRAAAAAAAEAGLAGLVITPGYDLRYLVGSRAQTFERLTALVLPADGAPTIVVPRLELASLKESAVTELGVAVADWVDGEDPYRLVVDALGGAPVAVAVTDSMPALHLLPLAEMLGVVPVLATDVLRRLRMIKDSAEIDALRKAGAAIDRVHARVPEFLVPGRTEADVAADIAEAIVAEGHSEVAFIIVGSGPHGADPHHECSDRELKKGDIVVVDIGGPYEPGYNSDCTRTYSIGEPDPEVARRYAVLQRAQAAAVSAVRPGITAEQVDAAARDVLAAEGLAGAFVHRTGHGIGLSVHEEPYIVAGNDLPLEAGMAFSVEPGVYFPGQWGARIEDIVVVTEDGALSVNNQPHDLVVVPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI81</accession>
    <name>A0A132PI81_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852891.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22013">
        <property type="protein sequence ID" value="KWX22013"/>
        <property type="gene ID" value="AFM11_22925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1938"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="241" mass="24912" checksum="9C0606E7CF537D06" modified="2016-06-08" version="1">MTSTSAPVLVVLGVGPGLGMSVAHRFGAEGHRVALISRSPQRHPDYLAALADKGVEAAAYVADANDSGRLRTALDAVRDRFGRIDVGYYGPAAFETAPTGDITGLDAAGAQAALDGVVPAVDFASQLLPEMRRRGSGGLLFAGGLSSVVPMPPLGGLALAAAALRNYAVTLHAALKPEGIYAGTITIGGLIERGDIHRAMADNAQFAGATTGTINPDDLAEQLWRLYRERTAAEEVVNLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIA6</accession>
    <name>A0A132PIA6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rlmN</name>
        <name evidence="13" type="ORF">AFM11_21425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852586.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04240"/>
    <dbReference type="EnsemblBacteria" id="KWX22076">
        <property type="protein sequence ID" value="KWX22076"/>
        <property type="gene ID" value="AFM11_21425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1633"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="114"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="236"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="(transient)" evidence="11">
        <location>
            <begin position="121"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX22076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="365" mass="39745" checksum="3647E9C12BFDFA34" modified="2016-06-08" version="1">MPGSLPLIFDAPRRAMPPRHLADLDEAGRAAEVTELGLPAFRAKQLANQYYGRLIADPQQMTDLPAAVRDQVAEALFPTLISPAREIQCDAGETRKTLWRAVDGTTFESVLMRYPQRNTVCISSQAGCGMACPFCATGQGGLKRNLSTAEILEQVRSASAAMRNEHDGRLSNIVFMGMGEPLANYNRVLAAVRRITAPSPNGFGISARSVTVSTVGLAPAIRKLADERLGVTLAVSLHTPDDELRDTLVPVNNRWPVHEVLDAARYYADVTGRRVSVEYALIRDVNDQPWRADLLGKKLHAALGPLVHVNLIPLNPTPGSEWDASPKPVEREFVKRVRERGVSCTVRDTRGREIAAACGQLAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIC1</accession>
    <name>A0A132PIC1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_22980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852909.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08225"/>
    <dbReference type="EnsemblBacteria" id="KWX22053">
        <property type="protein sequence ID" value="KWX22053"/>
        <property type="gene ID" value="AFM11_22980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1950"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="192"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="253"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="471" mass="50044" checksum="45CFC9DBE45C082D" modified="2016-06-08" version="1">MTRMPDRLARLFQPKYWGVSARSAAVAGSVVFVALTVAGVVLAAVVYRTLLSGVESAAVHRVGQISADLESGGPAQLDATLLATDRRVLAVQVMTPNGTVVRRSPSAPTTPLIPLDEIGPGLQIGIPEHASPFGQIQFSSGTVDTRSGRYIVLVGEGTEAVMSTVQAVAIALAVWTPLVMGVSAAATFVLVRRSMRSVDRIRTRVAEISTSDLAERVPVPNSRDEIAALAQTMNEMLARIEDGHAAQKRFVADASHELRSPLATIISALEVAADHPELLDQELAVSTLMPEAHRMRLLVDDLLLLARADEHGLAMGHDDVDLDDLAAREAEKLRRETSLQIRADISPTRVTGDAGALARVLRNLVDNAARHTVSLIDISVHTDGDRAVMSVGDDGPGIPEPDRLRVFDRFVRLDPDRSRRGGGSGLGLAIVAEVVAAHHGSVRIEDSPAGGTRVTVQLPLAGASYAPESSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIS7</accession>
    <name>A0A132PIS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_20620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852018.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06035"/>
    <dbReference type="EnsemblBacteria" id="KWX22246">
        <property type="protein sequence ID" value="KWX22246"/>
        <property type="gene ID" value="AFM11_20620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1461"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="205" mass="22840" checksum="83267269A4BBA94C" modified="2016-06-08" version="1">MVERRRYDSLRRLAQAKQTRAEIADAARRLFVTQGWAATTVRDVARAAEVSVPTVYAAYQNKAGLVWALVDAADLSADLPQMLDELESGATPRAHLAAMAGYDRRLFERAGDLIALIREAGRTEPDLAALYRQARQAADQTRIQVFSGWPDGTLRAGLDVQQAVDIYAALCNVGVYATLTVERGWPPDRVEQWWTDALARELIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ02</accession>
    <name>A0A132PJ02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein LppP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852091.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06245"/>
    <dbReference type="EnsemblBacteria" id="KWX22281">
        <property type="protein sequence ID" value="KWX22281"/>
        <property type="gene ID" value="AFM11_20830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1505"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025971">
        <property type="entry name" value="LppP/LprE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14041">
        <property type="entry name" value="Lipoprotein_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453306" evidence="1">
        <location>
            <begin position="28"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="164" mass="17506" checksum="4B8F950119A34EAC" modified="2016-06-08" version="1">MRLSRLSAVLLSLGFLAVGCGWSPPSAPPPKPDTCTPADGPAADTVAQEIAKLPAPKAGSEWIKVNEGHTSNCRLYWVQVGQTNPEPNSPGQLLFFDRQTPLGPATPEPRPYINVVTNADDSVVVNYQWQQGQDSPKAPTGIATVRFRIGDDGKLVAVDPIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJA2</accession>
    <name>A0A132PJA2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851858.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28635"/>
    <dbReference type="EnsemblBacteria" id="KWX22416">
        <property type="protein sequence ID" value="KWX22416"/>
        <property type="gene ID" value="AFM11_19880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1310"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="308" mass="33705" checksum="F97400813AD217CC" modified="2016-06-08" version="1">MTIRLGLQIPNFSYGTGVAELFPTVIAQAQEAENAGFDSVFVMDHFYQLPGLGTPDQPMLEAYTALGGLATATQKVQLGTLVTGNTYRNPTLLAKAITTLDVMSQGRAILGIGTGWFELEHDSLGFEFNTFTERFKKLDEALQIIVPMLKGERVTVDGTYYRTQEAFAEPRFREHIPLMIGGSGEKKTIPMAARHFDHLNIIANFDELPRKLDVIRQQCEQIDRDPATLETSMLVIALIGENFTADAIPPDFKQRAVFGSPEQIVEQLKTKLFDVGVDGVILSPVTIGGYVPGGVTEVGEALKPLISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJE0</accession>
    <name>A0A132PJE0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851910.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29955"/>
    <dbReference type="EnsemblBacteria" id="KWX22468">
        <property type="protein sequence ID" value="KWX22468"/>
        <property type="gene ID" value="AFM11_20155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1366"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016516">
        <property type="entry name" value="UCP07580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39456">
        <property type="entry name" value="PTHR39456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10118">
        <property type="entry name" value="Metal_hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007580">
        <property type="entry name" value="UCP07580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="299" mass="34134" checksum="369A26DB0ABB3E91" modified="2016-06-08" version="1">MLRPLRFDKEIDPGPVQIQARKVHFDLSGIPLHWIPGHPVASTMVNLFNVVLPAAEHWFVATFNEALPYVRDPKLADDMRGFIGQEATHAETHDKVLEEFLTTHGVEYEPILAMVEHVFKKMLAPTTATDPQRRLNDLCDRLWLIAAIEHYTAVLGDFVLNCTWEDYGADPTLTDLFRWHGAEEVEHRSVAHDVAVYFQDSYFSRVRAMSIAATAVYMFFQRGTWELLKRDSSVDIGWWRMNRMRMRDSKLGLLPKFSKMFGSNTLMYCRPSFTPDEMGSTAQAVAYLASSPAARAAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJI5</accession>
    <name>A0A132PJI5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="7">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFM11_20400</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22509">
        <property type="protein sequence ID" value="KWX22509"/>
        <property type="gene ID" value="AFM11_20400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1414"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="17">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KWX22509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="882" mass="93867" checksum="EF2360F38CECE2EF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJL3</accession>
    <name>A0A132PJL3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_20380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851950.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22539">
        <property type="protein sequence ID" value="KWX22539"/>
        <property type="gene ID" value="AFM11_20380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1410"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="346" mass="36152" checksum="5F5C841F927FCAE8" modified="2016-06-08" version="1">MKALVYQGPGARAWDEVADASIQQPGDAIVKVDAVTICGTDLHILKGDVPEVAQGRILGHEAVGTVTAIGSGVQRLSIGDRVLVSCITACGSCRYCRTASYGQCLGGGGWMLGHLIDGTQAEFVRVPFADYSTHKVPAGVTDEQMILLADILPTSYEVGVLNGTVRPADVVAIVGAGPIGLAAVLTSRLFSPSHIVVIDVADTRLEAARKLGADVVINSAAEDPGAVIGDLTSGLGADVTMEAVGLPQTFEEAVRLVRPGGHVANIGVHGAPATLHLEDIWMKNLTITTGLVDTYSTPSLIRLVASHQIDTSPVITHRFKLDEFETAYDVFSRASDTGALKVVLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJS6</accession>
    <name>A0A132PJS6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_20430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851958.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22514">
        <property type="protein sequence ID" value="KWX22514"/>
        <property type="gene ID" value="AFM11_20430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1420"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="89" mass="9420" checksum="430372CE373434BE" modified="2016-06-08" version="1">MVGDEDAIASVLNRLRRAQGQLSGVISMIEQGRDCKDVVTQLAAVSRALDKAGFKIVATGLRECLTGESADGAQPMTEAELEKLFLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK74</accession>
    <name>A0A132PK74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851054.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05000"/>
    <dbReference type="EnsemblBacteria" id="KWX22750">
        <property type="protein sequence ID" value="KWX22750"/>
        <property type="gene ID" value="AFM11_17480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.851"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="26879" checksum="F82042FA5E2B7011" modified="2016-06-08" version="1">MKLLDEVLGAYGGADRWREATSITIHQQVGGVLWPLKGVDGIINDSTVRIDLHEQRAWHRPLPRPGFRSSFRPAAVAIETDADHPEVVETLAAPRDSFAGHTLETPWSHLQLAYFAGYAMWTYLSEPFSLTLPGVETDELGTWAEDGQKWRRLGVRYPDSIATHSRDQVLYVDSDGLLRRRDYQVDIAGGSPAAHYADDHREFSGLVLPVKRVVYGRDADGHRIPEPITVTIDIDDVTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK81</accession>
    <name>A0A132PK81_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851591.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15105"/>
    <dbReference type="EnsemblBacteria" id="KWX22597">
        <property type="protein sequence ID" value="KWX22597"/>
        <property type="gene ID" value="AFM11_19015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1137"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="410" mass="44862" checksum="36338A140E0C6F57" modified="2016-06-08" version="1">MTTIAEGEAPQALMLQLLDPSNRADPYPLYDRIRECGPLHVADAALTVFSSYPDCDEVLRHPSSCSDPMKSTMTQRQMAEETEPRPRGTTSFLFLDPPDHTRLRKLVSKAFVPKVINALQPDITALVDGLLDAVEERGRFEAIADLAYPLPVAVICRLLGVPIEDEPKFSHASELLASALDPFFTVTGESSDLFDQQMKAGQWLREYLRELIEQRRRAPGDDLMSGLIAVEESGDQLTEDEIIATCNLLLIAGHETTVNLIANAILAMLRHPGQWSALAADPARAPAVVEETMRYDPPVQLVSRIAGDDMTIGDTAIAKGHTMLLLLAAAHRDAAVTDRPGEFDPDRGAIRHFGFGKGPHFCLGAPLARLEAAVALSAVTRRFPQARLAEEPVYKRNLTLRGMSTLSVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKF3</accession>
    <name>A0A132PKF3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid APC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_20355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851945.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22502">
        <property type="protein sequence ID" value="KWX22502"/>
        <property type="gene ID" value="AFM11_20355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1405"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043858">
        <property type="term" value="F:arginine:ornithine antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903826">
        <property type="term" value="P:L-arginine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004754">
        <property type="entry name" value="Amino_acid_antiprt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022461">
        <property type="entry name" value="Arg/Orn_antiprt_ArcD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00905">
        <property type="entry name" value="2A0302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03810">
        <property type="entry name" value="arg_ornith_anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="492" mass="51900" checksum="EB09DEDB7A5934F0" modified="2016-06-08" version="1">MSQTLVPPTPKARPSTTKTGLGLAALTAIVVGSMIGSGIFALPSQMAGSAAPGPLIIGWAITGVGMLTLAFVFQTLATRKPEIDGGVYGYARAGFGNYIGFTAAFGYWVSAWVGNVAYLVLLFSTLGYFFPQFEGGATLPAIIGASILLWIVHAMTLRGIQTAAFVNVVVTFAKVVPILVFIAIAAVGFKADLFGADFWGRTTQIDGAPLGDTMTQVKNMMLVTVWVFIGIEGAAVYSQRAAKRKDVGRATVLGFAGVLALLLLVNLLSYGLMAQADLAGVPDPSMAGVLANEVGSWGAAFISIGLVMSLLGALIAWVMLCVEILRLPAVEHVMPKVLARENKHGAPANALWLTNLCVQALLLWTLANESTYTNLVYLATSLILLPYLWSAAYQVLLALRGETYESGHGRARDLIIGVVALGYAVWLVYAGGWQYLLVAALFYLAGTALYLWARKESRLPAFTKAELAVAAVVALTSVAAVALMATGNLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKU7</accession>
    <name>A0A132PKU7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_17835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22807">
        <property type="protein sequence ID" value="KWX22807"/>
        <property type="gene ID" value="AFM11_17835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.921"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="453"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="540" mass="58012" checksum="C226F8E677D68529" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKZ0</accession>
    <name>A0A132PKZ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850716.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01255"/>
    <dbReference type="EnsemblBacteria" id="KWX23008">
        <property type="protein sequence ID" value="KWX23008"/>
        <property type="gene ID" value="AFM11_16685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.687"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="214" mass="23240" checksum="A4371F38469264C9" modified="2016-06-08" version="1">MKLRRRPDLTLQDRVVWQAASLLLAYPDERHQARLDTVEGLLAHIAGEQARLIAETLTALRDTPAMALAAQYVDTFDLKKSTTMLLTYWTGGDTRNRGAQMVVFTQAYRDAGVQPPRQEAPDHLPVVLEFAATVDPVAGRRLLAAHRVPIDVLRHALSDAGSPYAPAVAAVCSTLPAVSGGDAQHLLRSGPPTESVGLQPFQLTVPPRRVEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM15</accession>
    <name>A0A132PM15_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849659.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09520"/>
    <dbReference type="EnsemblBacteria" id="KWX23395">
        <property type="protein sequence ID" value="KWX23395"/>
        <property type="gene ID" value="AFM11_13950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6893"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="230" mass="25992" checksum="B075F22AFCBB9A28" modified="2016-06-08" version="1">MNAPVRTAVQRRRGVRREQLSDEVAAHLRAEIMTGVLRPGTFIRLDETAAALGVSITPVREALRTLRGEGMVQLEPHRGHVVVPLSRTDVEDIFWLQATIARELAATTTERITDAEIDELERLNAELAAAVDRHDPEEISATEFAFHRAFNHASGRIKLAWFLLHVARYLPALIYSTDPRWGHEAVESHRRLIDALRRRDTRTAVELNGGQFTDGAQRLIARLDEIGMWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMA5</accession>
    <name>A0A132PMA5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_15190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850139.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15810"/>
    <dbReference type="EnsemblBacteria" id="KWX23172">
        <property type="protein sequence ID" value="KWX23172"/>
        <property type="gene ID" value="AFM11_15190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7150"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="296" mass="31456" checksum="1C53D7B9950CB75A" modified="2016-06-08" version="1">MVSQPEPVVTGDAVILDVSIAQLPVRALAVLIDIVVVFVGYLVGVMLWAITLSQLDDALSAAILIIFTVLTIVGYPVIMETATRGRSLGKMALGLRVVSDDGSPERFRQALFRGLSGFIEIWMFTGGPAVICSLLSPKGKRIGDIFAGTVVISERGPKLTPPPAMPPTLAWWASSLQLSGLRAEQAELARQFLSRANQLDPRVRDDMAYRILGEVAAQISPPPPPGAPPQYVLAAVLAERHRRELARLTPAGPPPPHPAPPPTFAPVPQPPIQPPPAPPVQPPHSAPPTSGFTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMC9</accession>
    <name>A0A132PMC9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849824.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23475">
        <property type="protein sequence ID" value="KWX23475"/>
        <property type="gene ID" value="AFM11_14435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6996"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="368" mass="40900" checksum="07DCD51F4EFF12D8" modified="2016-06-08" version="1">MADSWEVILHHTYRGAPGVVYDSSPIKGAHGVAVGGVKFHPDGQGPDSGSISFRNAASCIHVEATKGWDTLGALKIETVCRFGLAARRGHFQSLIRYRDRFLLGVYGSNPNTRTVHILASVHTGTPQRFGILSPRLPVDEWLTLGVWFNGWDRLELSVDGAVVKTKTSAIGVGPLSGRSPAIIDIGGRGYHRVRFEGRIDEVRISRSNPRAVAEDFLNRPMDSETAECWVRWGRKLLDWLRQNPRCADEFAALVTQMRHTVYAIDRDAELRDMFRRAAETYRKEWRTGLLASDAMVDALVAVSSVIGRSDLPVQASVDLLTASDCWRRLRMEVPVPQCDPQLAQLANVVTETLEEGQGRAHQDADNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMP5</accession>
    <name>A0A132PMP5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">radA</name>
        <name evidence="8" type="ORF">AFM11_16005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850430.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16580"/>
    <dbReference type="EnsemblBacteria" id="KWX23312">
        <property type="protein sequence ID" value="KWX23312"/>
        <property type="gene ID" value="AFM11_16005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7326"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="68"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="356"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="463" mass="48020" checksum="EA24BE56711A641A" modified="2016-06-08" version="1">MAGSKVRSQYRCSECQHVTPKWVGRCSNCGTWGTVDEVAVLSSVGGSVRRSVAPNSPAVPITSIDPGVTRHYSTGVSELDRVLGGGLVAGSVTLLAGDPGVGKSTLLLEVANRWAHTGRRALYLSGEESAGQIRLRAERTHCTHDNVYLAGESDLQIALGHIDEVRPSLVVVDSVQTMSTTEADGVTGGVTQVRAVTTALTAYAKMATGDPAVAMILVGHVTKDGAIAGPRSLEHLVDVVLHFEGDHTSSLRMVRGVKNRFGAADEVGCFQLHDNGIECVSDPSGLFLDQRTAPVPGTAVTVTLDGKRPMIGEVQALVAPPAGPPRRAVSGIDSARAAMIGAVLQTRCGLPIGGNDLYLSTVGGMRLTDASADLAVALAIGSAYLGIALPMNAVAIGEVGLAGDLRRVTGMERRLTEAARLGFNVAVVPPGINSVPKGLRAITVDNIRAALRALKDIGEDGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMX5</accession>
    <name>A0A132PMX5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849059.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03080"/>
    <dbReference type="EnsemblBacteria" id="KWX23665">
        <property type="protein sequence ID" value="KWX23665"/>
        <property type="gene ID" value="AFM11_12760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6643"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="57"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="36448" checksum="E4343F635599E5A3" modified="2016-06-08" version="1">MREAFGAEFAGAEGFLNSPTYGLPPQFLVEALHRCIADWQAGTMDAASFDEPVRLGRAGYAALAGVPVESVTFAGNVSAALGLVAAAVPDGSRVAVLKGEFTSTTFPFAAQSARGVTVTELAPDELVGSAAEYDVIAVSLVQSATGAVLDSAALRAAITGTDTLTVVDVTQAVGWKHLDMAWADVTVAGVYKWLLAPRGAAWMSLSDRVATRMTPHAANWYAGEDPWQSIYGLPLRLAPDARRFDASPAWFPMLGAGLTLPWLASLDPVVLESHTVGLANRLRAEIGLPQHDSAIVSLPVTDAAERLQRAGIRAAVRAGAVRVGFHLYNTEDDLERLLDVLGDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMY8</accession>
    <name>A0A132PMY8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849174.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03280"/>
    <dbReference type="EnsemblBacteria" id="KWX23701">
        <property type="protein sequence ID" value="KWX23701"/>
        <property type="gene ID" value="AFM11_12995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6691"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="373" mass="40372" checksum="0A76BFCF5AD75B92" modified="2016-06-08" version="1">MDSDGRSGGRPTGVPGNAGGTESADAAPYPKVVLVTGACRFLGGYLTARLAQNPLINHVIAVDAIAPSKDLLRRMGRAEFVRADIRNPFIAKVIRNGDVDTVVHAAAASYAPRSGGRATLKELNVMGAIQLFAACQKTPSVRRVILKSTSEVYGSSSRDPVMFTEESSARRPPGEGFARDSMDIEGYARGLARRRPDIAVTILRLANMIGPAMDTALSRYLAGPVVPSVVGHDARLQLLHEQDALGALERATVAGKAGTFNIGAAGIVMMSQAIRRSGRIRLPVPRSALSVVDSLSRATRYTELDREQLNYLSYGRVMDTTRMLNDLGYHPKWTTAEAFDDYVRGRGLTPIIDPRWVRSMESRAVGMAQRWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN14</accession>
    <name>A0A132PN14_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09265"/>
    <dbReference type="EnsemblBacteria" id="KWX23587">
        <property type="protein sequence ID" value="KWX23587"/>
        <property type="gene ID" value="AFM11_14135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6931"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="15"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="194" mass="20765" checksum="1E95E065418C31BF" modified="2016-06-08" version="1">MGCGGVRDKLTANGQWTLDGSDGELLLHTGVTGTAARMGHRLTIAMRSWQATVQWSGDDPVEVAVTVDLESLDVIRGEGGVTPLSGAEKKLVRANATKSLRTGKFPHARFRSTAIERDTDVIRLIGTLEINGRAGEQTVDIRVEDDGDSWRISGAAVVAHTDFGIKQYSMMMGAMKVADEVRVTFAAGHLKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN71</accession>
    <name>A0A132PN71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02920"/>
    <dbReference type="EnsemblBacteria" id="KWX23647">
        <property type="protein sequence ID" value="KWX23647"/>
        <property type="gene ID" value="AFM11_12640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6618"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="1">
        <location>
            <begin position="233"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="366" mass="39739" checksum="095D4DB884FBC898" modified="2016-06-08" version="1">MTTLRGTAVTARVGVALGVAVAVCFVTGLISHFIQHPQPWFYWPTRPVGLYRFTQGLHVISGIAAIPLIVVKLWSVWPKLFERPLIGGPVRQLERASILVLVASMLFQLSTGLLNTAQWYAFEFFFTTSHYAMAYVAAGAVLVHIAVKLPVIRRALGEPLDEGSTTRLTGPTRRTVLRGTWLAVTLATVVTAGQTIPLLRRVSVLAPRSGQGPQGVPVNRSAAAAGVVVSARSPQYRLTVTNGPVKREFTVDDLRAMPQATHRLPIACVEGWSADAEWTGVALADLIRAVGGSSDSDVRMISLEPPGPYSRTTLPARHARDRQTLIALRLNGETLDLDHGYPCRLIAPTRPGVLQTKWLSRIEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNM3</accession>
    <name>A0A132PNM3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putrescine importer PuuP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_11170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848080.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30730"/>
    <dbReference type="EnsemblBacteria" id="KWX23930">
        <property type="protein sequence ID" value="KWX23930"/>
        <property type="gene ID" value="AFM11_11170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6311"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="22"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="447" mass="47459" checksum="D2C866A4C038B24F" modified="2016-06-08" version="1">MSNTTEVTEGQLRRALGLPSLVLFGLVYMVPLTVFTTYGIVTQTSGGRLPLAYLVTLAAMVFTARSYARMAVAYPVAGSAYTYTQKSFGAPVGFLAGWSLMLDYLFLPMINYLVIGIYLEAAFPAVPAWIFILIAIAIVTVLNIVGIVSVARANFVIIAIQAIFIVTFLVLACSKVFGLGTVDLAAPFTGDGTAPGFSPIFAGAAILCLSFLGFDAVSTLSEEAKDPKRTVPQAIMIATVVSGLIFVVLSYLGQLVFPSNEFADVDSGSLDVMVTAGGQFLETFFTAAYVAGALGSAITSQASVARILYAMGRDGILPRSIFGYVSPRYSTPVYAILVVSVVSLLAVVIDLATMASLVSFGALVAFSVVNLSVIKHYYVDKRERAGAQVIGSLVLPLIGFLLTVWLWTSLSGLTLIIGLCWLAVGFVWLAGVTRGFQQPTPVLDMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNX7</accession>
    <name>A0A132PNX7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848387.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30310"/>
    <dbReference type="EnsemblBacteria" id="KWX24025">
        <property type="protein sequence ID" value="KWX24025"/>
        <property type="gene ID" value="AFM11_11715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6420"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453502" evidence="3">
        <location>
            <begin position="30"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="4">
        <location>
            <begin position="60"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="382" mass="38676" checksum="2AD3B68DB6968BE0" modified="2016-06-08" version="1">MASPRLLATFVAMSGLLLACSSPSSPQPAPTTEPPAMQPVATNEPLPAAPQSCDLASLPVRDKLAQLLTVGVTGAADARAIVANQHVGGIMVGSWTDLSMLTDGSLADIVANSGPLPLSVSVDEEGGRVSRLSSLIGSQPSARDLAQTRTADEVYGIALERGRAMRGLGITVDFAPVVDVSANSAAIGDRSFGDDPAVVTEYAGAYARGLRDAGVLPVLKHFPGHGHASGDSHTGSVTTPPLADLQNNDLVPYKTLTTAAPVAVMVGHMQVPGLTGADPASLSPAAYQLLRSGGYGGPGFNGVVYTDDLSSMAAINQRYGVADAVLRALRAGADNALWVTTGEVPAVLDGLEQAVAAGDLSQAAVDASLQRVAAAKGGIRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP80</accession>
    <name>A0A132PP80_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848786.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09565"/>
    <dbReference type="EnsemblBacteria" id="KWX24148">
        <property type="protein sequence ID" value="KWX24148"/>
        <property type="gene ID" value="AFM11_12415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6562"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="30482" checksum="429B457D37A6FAFB" modified="2016-06-08" version="1">MEDQPADPGDLTSDDQKPRRRWGFGRKRNAEQAAEETDRNEPSPEARPKRTPVGKGRRAAAVEPEVEREPEAEVEAEPEPEPEAEAADPEEPEPAAEEKPEPVLVPHRPAGKRLTHAAVGAAAVFVAAGAFAGAMVQPYLSDRALVDTKLQVAQTSADAITTLWTYTPDNIESLPDRASRYLSNDFANQYRQFIDSIVPSNKQAQITNNTQVVGTAVESISPTEATAIVYTNSVSTSPVTKNVPSLRYLSYRLTLVRDGGDWRITQMPALTQLDLSPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP91</accession>
    <name>A0A132PP91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OHCU decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31245"/>
    <dbReference type="EnsemblBacteria" id="KWX24158">
        <property type="protein sequence ID" value="KWX24158"/>
        <property type="gene ID" value="AFM11_11010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6278"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017595">
        <property type="entry name" value="OHCU_decarboxylase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03180">
        <property type="entry name" value="UraD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="2">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="150" mass="16687" checksum="F0D4FD3814041FEE" modified="2016-06-08" version="1">MHMLFEVCTSPIWARRVLAGSPFRNVDALLDRADRVLAELPDAEIDAALDGHPRIGGRVDNASSAREQAGVADADKAIRAELAAKNQAYEDKFGYVYLVCASGRSAEELLAILTERLCNDPETERRVMRSELAKINRLRLQRLFTEEATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP96</accession>
    <name>A0A132PP96_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30585"/>
    <dbReference type="EnsemblBacteria" id="KWX24166">
        <property type="protein sequence ID" value="KWX24166"/>
        <property type="gene ID" value="AFM11_11310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6339"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="574" mass="62283" checksum="581E2D9FA66AC953" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPG2</accession>
    <name>A0A132PPG2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proA</name>
        <name evidence="9" type="ORF">AFM11_09490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847131.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05735"/>
    <dbReference type="EnsemblBacteria" id="KWX24221">
        <property type="protein sequence ID" value="KWX24221"/>
        <property type="gene ID" value="AFM11_09490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5935"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="10"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="421" mass="43718" checksum="B09DB8501157A5CA" modified="2016-06-08" version="1">MSVQTQSSAVVVPDADLRGQVHDAARRARVAARTLATLSAAAKNSALHAAADSVLSHVHEVLAANAADVEAARAAGTPEAMLDRLALNPQRVDGIAAGLRQVAGLPDPVGEVLRGRTLPNGLQLRQQRVPLGVVGMVYEGRPNVTVDAFGLTLKSGNAALLRGSSSAARSNEALVIALRSALAGEGLPLDAVQLLPSHDRASVTHLIQARGLVDVVIPRGGAGLIDAVVRDAQVPTIETGVGNCHVYVDESADLDLAEKILLNSKTRRPSVCNAAETLLVDRAVAETALPRLTAALQDAGVTVHADPTDDELRAEFLSMDIAVAVVDGVDGAIDHINTYGTGHTEAIVATDLAAAQRFTERVDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGDGQTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPK7</accession>
    <name>A0A132PPK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Daunorubicin resistance protein DrrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848745.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09635"/>
    <dbReference type="EnsemblBacteria" id="KWX24137">
        <property type="protein sequence ID" value="KWX24137"/>
        <property type="gene ID" value="AFM11_12345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6548"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="5"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="482"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="516"/>
            <end position="523"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="788" mass="83882" checksum="2A99ED4084680F93" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPL2</accession>
    <name>A0A132PPL2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847327.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24286">
        <property type="protein sequence ID" value="KWX24286"/>
        <property type="gene ID" value="AFM11_09860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6010"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="490" mass="52156" checksum="24092B2B4295E2C9" modified="2016-06-08" version="1">MADVVVVGAGPTGLMLAGELARGGVSVELVDRARERAGTSRAAGVNARTMEVFDQRGMLDAFEARGTPMDAGHFSGIRLDMSALPTRRGYTLAIMQTETESVLERFAAELGVTVQWGVEVTGLEQDATGVVVTTAGPDGPQRRRADYVVGCDGSRSAVRGLAGIPFEGTDAEFVTLLGDVEVSDPPPGRTFLERTDTGVVTFLPFGQLSGQTWQRVMVTEYDPSEQKGELGLDDLRTALNTVAGKDFGVHSPVWLSRFADVSRQATSYRAGRVFLAGDAAHIHPPLGGQGMNLGIQDATNLGWKLAAVIRGDASRELLDTYHDERHPVAQRVLENTRAQTALLAGGANVTAMRDTFRGLLDIDAVNERVGAAISGLDVSYGSDADHVLVGRRIPDCDIRVGGTLRRLYELLHDARPVLIDFGAGLGRDAVEAIPIGASWRVPLFGRVPIPPAVLVRPDGHVAWVSVDGSDSGLDRAAERIGAAHLVNART</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPR3</accession>
    <name>A0A132PPR3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PknH_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_10170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847493.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24336">
        <property type="protein sequence ID" value="KWX24336"/>
        <property type="gene ID" value="AFM11_10170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6072"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026954">
        <property type="entry name" value="PknH-like_Extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038232">
        <property type="entry name" value="PknH-like_Extracell_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14032">
        <property type="entry name" value="PknH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453473" description="PknH_C domain-containing protein" evidence="4">
        <location>
            <begin position="32"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PknH_C" evidence="5">
        <location>
            <begin position="39"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="228" mass="25001" checksum="97D09B075B75220C" modified="2016-06-08" version="1">MPERRLLRCVTAFLALLITLTGCAGHGNVDAEPTVVGDADLNGLLLSTDQMNTLMATTGMTPHPMVTTMGDHRNLLPNLNCLGVWQVNEAAIYGDGWDALRQQLLRSPDTDNWDNLVVQSVVSYQSEQDARDFYRESADRWSKCADHNVNINLNGQQLPKWRSGALAETDTELSMPFTRGTGAQTRSCQRVLAVEANVIIDVQACKPASETVTQAAMVADTIKASLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ12</accession>
    <name>A0A132PQ12_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_12310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848706.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09670"/>
    <dbReference type="EnsemblBacteria" id="KWX24132">
        <property type="protein sequence ID" value="KWX24132"/>
        <property type="gene ID" value="AFM11_12310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6541"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1232" evidence="6">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="136" mass="14970" checksum="87C145FAB4473110" modified="2016-06-08" version="1">MADAWWVDALIGLAVALLLSWVVLVIALLVMRPRGNLLTEALRLLPDLLRLIPRLAADKSLPRGVRIRLALLVVYLAVPIDLIPDFIPVLGYADDAIIVTWVLRSVVRHGLDAVRAHWPGTDDGFDALARLTGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ26</accession>
    <name>A0A132PQ26_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847732.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19170"/>
    <dbReference type="EnsemblBacteria" id="KWX24413">
        <property type="protein sequence ID" value="KWX24413"/>
        <property type="gene ID" value="AFM11_10655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6171"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="30072" checksum="C6CE99D486C4E66F" modified="2016-06-08" version="1">MARSAPHPRVVMVDGVPMSALVAEAADPRAVVVALHGGATTSAYFDCPGHPELSLLRAAVERGFTVVAVDRPGYGASAAYPDAMARPDQRVALAFGAVERIAGPGPVFVLGHSMGCELAVRMAVTGSVLGVSLAGTGLRYRSGARDILKNAAVDHRPRGLRDLLWQPERLYPGDVLGNGLSAGGTLYEADVVKTWASHDFPELAAQVTVPVQFLAGDHENVWESDADALAKIAALFRAAPRVDVGEVAESGHNLSVGLTASTYHRRVLSFADECVAGSARTATEVEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ54</accession>
    <name>A0A132PQ54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847876.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19450"/>
    <dbReference type="EnsemblBacteria" id="KWX24461">
        <property type="protein sequence ID" value="KWX24461"/>
        <property type="gene ID" value="AFM11_10935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6226"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="292" mass="31990" checksum="D80A8B28C172D2E4" modified="2016-06-08" version="1">MTSTAVEFESVWSDLQGVAFSQGYLDVGGVRTRYLHAGDPNLPALVLLHGSGGHAEAYVRNLESHAEHFSTWSIDMLGHGYTDKPGHPLEVAHYVAHLVGFLDAIGAPRAHISGESLGGWVAARAAVDHPHRIDRLVLNTAGGSQADPEVMKRIITLSMAAAENPTWETVQARIKWLMADKSKDYDDIVASRQRVYRQPGFVSAMSDIMALQDPEIRARNLLGEKEYGSITAPTLVVWTSDDPTADVAEGRRIASMIPGARFEVMPGCGHWPQYEDPATFNRLHLDFLLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQM7</accession>
    <name>A0A132PQM7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08150</name>
        <name evidence="2" type="ORF">AWC31_00075</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000001">
        <property type="protein sequence ID" value="ORX19295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24638">
        <property type="protein sequence ID" value="KWX24638"/>
        <property type="gene ID" value="AFM11_08150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19295">
        <property type="protein sequence ID" value="ORX19295"/>
        <property type="gene ID" value="AWC31_00075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5481"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX19295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="145" mass="15747" checksum="18F71C5B4ACC7E68" modified="2016-06-08" version="1">MLEERRAGDAAVVGTHHPRARRGRELLAVAVPRRPTGTVGVHQHHGVGGFDRRLIGAGVQRVQPVDAEQPRVKRQRVEVGVLHPADRQVKTAVGDTGGLRVRRHHPRVHPQFGDARGPLGPIGRAPVHTADAHRVGDRHTFCAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQN7</accession>
    <name>A0A132PQN7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_08205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846338.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00130"/>
    <dbReference type="EnsemblBacteria" id="KWX24649">
        <property type="protein sequence ID" value="KWX24649"/>
        <property type="gene ID" value="AFM11_08205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5492"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="322"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="503"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="715" mass="76099" checksum="CB652A366769DB61" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQW1</accession>
    <name>A0A132PQW1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="11" type="ORF">AFM11_08595</name>
        <name evidence="12" type="ORF">AWC31_13775</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846528.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13775"/>
    <dbReference type="EnsemblBacteria" id="KWX24716">
        <property type="protein sequence ID" value="KWX24716"/>
        <property type="gene ID" value="AFM11_08595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18376">
        <property type="protein sequence ID" value="ORX18376"/>
        <property type="gene ID" value="AWC31_13775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5570"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="15"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX24716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX18376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="510" mass="54419" checksum="F35EDBE3BA96A514" modified="2016-06-08" version="1">MTGHQLDENEPREECGVFGVWAPGEEVAKLTYYGLYALQHRGQEAAGIAVADGSQVLVFKDLGLVSQVFDEQTLAAMPGHVAVGHCRYSTTGSTTWENAQPVFRNTAAGTGVALGHNGNLVNTAELAARARDAGLIDMKGAPAATTDSDILGALLAHGAADATLEQAALELLPTVRGAFCLTFMDENTLYAARDPHGVRPLSLGRLDRGWVVASETAALDIVGASFVRDIEPGELLAIDADGVRSTRFANPEPKGCVFEYVYLARPDSTLVGRSVHATRVDIGRRLAREHPIDADLVIGVPESGTPAAVGYAQESGIPFGQGLMKNAYVGRTFIQPSQTIRQLGIRLKLNPLREVIRGKRLIVVDDSIVRGNTQRALIRMLREAGAVEVHVRIASPPVKWPCFYGIDFATPAELIANAAPQEHEGEMLEAVRHAIGADTLGYISQQGMIAATEQPATRLCSACFDGNYPIELPGENALGKNVIEHMLASAARSGIPVQADNDNASALRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQW9</accession>
    <name>A0A132PQW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacteriocin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_08675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Encapsulin nanocompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the encapsulin family. Family 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846564.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13695"/>
    <dbReference type="EnsemblBacteria" id="KWX24729">
        <property type="protein sequence ID" value="KWX24729"/>
        <property type="gene ID" value="AFM11_08675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5585"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007544">
        <property type="entry name" value="Linocin_M18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04454">
        <property type="entry name" value="Linocin_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019254">
        <property type="entry name" value="CFP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1284">Encapsulin nanocompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="28699" checksum="013121C0A50E9A39" modified="2016-06-08" version="1">MNNLYRELAPITESAWAEIELEATRTFKRHIAGRRVVDVSEPGGPVTAAVSTGHLLDVNPPGDGVIAHLRDAKPLVRLRVPFTVARKDIDDVERGSQDSDWDPVKDAAKKLAFVEDRAIFEGYGAASIEGIRSSSSNPALALPDDAREIPDVIAQALSELRLAGVDGPYSVLLSAETYTKVSETTAHGYPIREHINRLVDGEIIWAPAIDGAFVLSTRGGDFDLQLGTDVSIGYLSHDAEVVHLYMQETMTFLCYTAEASVALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR59</accession>
    <name>A0A132PR59_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846867.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13115"/>
    <dbReference type="EnsemblBacteria" id="KWX24821">
        <property type="protein sequence ID" value="KWX24821"/>
        <property type="gene ID" value="AFM11_09255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5699"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="260" mass="27544" checksum="D65ADEC705486A32" modified="2016-06-08" version="1">MTGMLQGKVVVISGVGPALGTTLARRCAEAGADLVLAARTVERLEEVAKQVTDLGRRAITVGTDITDEAQVGNLVEESLKAYGKVDVLINNAFRVPSMKPLANTTFDHMRDAIELTVFGALRLIQGFTPALAEANGAVVNVNSMVVRHSQAKYGAYKMAKSALLAMSQSLATELGEQGIRVNSVLPGYIWGGTLESYFNHQAGKYGTTVEEIYKATAAASDLKRLPTEDEVASAILFMASDLASGITGQALDVNCGEYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRA4</accession>
    <name>A0A132PRA4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846773.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13295"/>
    <dbReference type="EnsemblBacteria" id="KWX24794">
        <property type="protein sequence ID" value="KWX24794"/>
        <property type="gene ID" value="AFM11_09075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5664"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="169" mass="18750" checksum="9E7230042D8C1C7C" modified="2016-06-08" version="1">MSTVERSTPPLAGDERATLESWLDFYRATLAAKCAGLSEQQLRTASVPPSSLTLMGIVQHETEVERNWFRRVLIGEEVPSIYGPRSTEGHDGGFDPAIDIDFETAYARWQSEIEQSKANCAGRALDDTSPFMGSEVTLRWIYTHMIAEYARHCGHADLIRESIDGATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRF3</accession>
    <name>A0A132PRF3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_08045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846253.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24645"/>
    <dbReference type="EnsemblBacteria" id="KWX24622">
        <property type="protein sequence ID" value="KWX24622"/>
        <property type="gene ID" value="AFM11_08045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5459"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="159"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="341" mass="38151" checksum="4CB64F14EBED6B47" modified="2016-06-08" version="1">MAQGSYVADKSSSGGEFNRDTNYITTRITADGHDGYPVEPGRYRLIVARACPWANRTIIVRRLLGLEDVLSIGFCGPTHDERSWTFDLDPDGLDPVLRIPRLQDAYFKRDPNYPKGITVPAIVEVASGAVVTNDFAQMTLDFSTEWTAYHREGAPQLYPEPLREEIDAVAKRIYTEVNNGVYRCGFAGSQEAYDAAYDRLFTALDWLSERLATQRYLVGDTITEADVRLFTTLARFDPVYHGHFKCNRSKLAEMDVLWAYARDLFQTPGFGDTIDFVQIKQHYYIVHADINPTQIVPKGPDLSDWLTPHGREALGGRPFGDGTPPGPTRQGERVPAAHSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRW6</accession>
    <name>A0A132PRW6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_06435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845308.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29240"/>
    <dbReference type="EnsemblBacteria" id="KWX25060">
        <property type="protein sequence ID" value="KWX25060"/>
        <property type="gene ID" value="AFM11_06435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4480"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2028"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="2110" mass="222901" checksum="22A897B0D1512DE2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS69</accession>
    <name>A0A132PS69_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_06920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845498.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28730"/>
    <dbReference type="EnsemblBacteria" id="KWX25145">
        <property type="protein sequence ID" value="KWX25145"/>
        <property type="gene ID" value="AFM11_06920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4583"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="223" mass="23985" checksum="19D95512472A46E1" modified="2016-06-08" version="1">MPAQVQRHPLAAQTASLLLARIRDGEWPLGHRLPGETTLAAQLGVGRSTLREAIRELAGKGVLDSRQGAGVFVTALDVAEDWDTVLRRSTIVSVIEARIAIEAEAAALAATRRTPADLRTIRRTLVARGVVGQSVPDHVDADMAFHRAVIAAAHNDVLTQLFDAFLPRLRLAMIDMLKIKPIASEPCDHALHQQLADAIVARDPEAAAAASRTHLSSLKESFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSD6</accession>
    <name>A0A132PSD6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_05555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845785.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12930"/>
    <dbReference type="EnsemblBacteria" id="KWX25233">
        <property type="protein sequence ID" value="KWX25233"/>
        <property type="gene ID" value="AFM11_05555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4301"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="338" mass="36158" checksum="05A6A1399E9950EA" modified="2016-06-08" version="1">MAKSKQATLQSIADDLGLHVSTVARVLNGMRQGERAASGATAERIRKRAAEVNYRPNPHAASLRTRRTNLIGVLVPRLSDVVLATVYEGIESAASARGLTAFVANTQDEPADQRKRIEMMLDRRVDGLILGDARADDHTVLEELRRREVPFVLVNRSVAGYPAATCDNYLGGRLAAEHLLELGHRDVGVIAGLAHASTGIDRPAGFVDRYREAGIEVPSYNIVFSGLDSHGGHYAADRLLAGSTPPTALFAVNDFAAIGAAGAIRNHGLRVGEDVSLIGFNNIALTAELHVPLTSIESHAFDMGRDAVQLLTEALAGQDPDQLRTTPVLVARESTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSN9</accession>
    <name>A0A132PSN9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843812.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25284">
        <property type="protein sequence ID" value="KWX25284"/>
        <property type="gene ID" value="AFM11_03030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2474"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="591" mass="64191" checksum="B6A03E37FE1FF2EB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSQ6</accession>
    <name>A0A132PSQ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_transf_28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845311.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29220"/>
    <dbReference type="EnsemblBacteria" id="KWX25062">
        <property type="protein sequence ID" value="KWX25062"/>
        <property type="gene ID" value="AFM11_06455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4484"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033072">
        <property type="term" value="P:vancomycin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="421" mass="45746" checksum="164C25655C63C5A5" modified="2016-06-08" version="1">MRFAIAAHGTRGDIEPCTALALECVRRGHDVRMAVPPNLVSFVEATGLGPVASYGVDSQQQLEAEIFRKSWKLQNPLTALRQLKDYTTEGWQDMSRTLVEVADGADLILTATTYEEVAANVAEHLGLPLAALHYFPFRANTHILPVPLPGRLVRSVWPAAEWLHWRLIKDAEDVQRRDLGLPKSSGRAIGRILDAGALEIQAYDPQFFPGLAEAWRGVRPVIGGLTLQLDTDADHDVSAWIAAGPPPIYFGFGSMPVQSPSAAVAMIADACSALGERALICSGVWDVDGADVPEHVKIVRTVNHSAVFPRCRALVHHGGAGTTAAGLRSGIPTFVLWVGAEQPLWAAQVKRLEVGTAQRFSEMTHKSLRVGLRTVLEPRYLARAREVAERMTAPEVAVATAADLLEAAVRKGRSPVRQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT55</accession>
    <name>A0A132PT55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844356.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25444">
        <property type="protein sequence ID" value="KWX25444"/>
        <property type="gene ID" value="AFM11_04085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2695"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="13"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="373" mass="39319" checksum="1683230EB0ED5E75" modified="2016-06-08" version="1">MANAHPALTAQRVGTLTLDNKFAVAPMTRVSATPDGAATTEMADYYRGFARGGFGLLLTEGIYTDVTHSQGYLNQPGLATDAHVQAWRPVTDGVHAHGVPIVAQLMHAGALSQGNAHGAGTIAPSAITPRGTMLDEYGGSGGWPTPQEMTRDEIDTVVSSFGDAAVRAQAAGFDGVEVHAANGYLLDQFLTAYTNTRDDEYGGGVANRIKLAARVLSEIRNRVAEGFLVGVRLSQTKVNDFTYRWPGGAADAEIIFATLAGTGADYLHIASEGRDFIDTARFSDGRTITALAREVSGLPVMANGGMHDLRQAADVLEGGHADLLSIGRGALANPDLPRRVAAGEDLEGFDHEMLSPMATIANARNWRTAESVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT58</accession>
    <name>A0A132PT58_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_04620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844570.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20525"/>
    <dbReference type="EnsemblBacteria" id="KWX25529">
        <property type="protein sequence ID" value="KWX25529"/>
        <property type="gene ID" value="AFM11_04620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2803"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="322"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="512" mass="54772" checksum="8B265298D586F3BC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTA0</accession>
    <name>A0A132PTA0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_04405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844484.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20740"/>
    <dbReference type="EnsemblBacteria" id="KWX25494">
        <property type="protein sequence ID" value="KWX25494"/>
        <property type="gene ID" value="AFM11_04405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2757"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="219" mass="24006" checksum="A4E790CA0C1C40A1" modified="2016-06-08" version="1">MRIAVVEDDDGVGEALVDALAEVGHSPVRMRRGADLLLGHRDVDLVLLDLGLPDADGLTVLRQLRVVSQVPVVVLTARDDERSVVRALRGGADDYVVKPARLGELRARIEVVARRRMAAADEEPDTVESGDIVVDLNGRRVEVGGEEISLAPKEFEVLAYLVARRGEAVSRQEMMDAIWGDAYVAISRSLDVHMTSLRAKLGRPEAITTIRGYGYRWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTG9</accession>
    <name>A0A132PTG9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844799.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25639">
        <property type="protein sequence ID" value="KWX25639"/>
        <property type="gene ID" value="AFM11_05280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2941"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="121" mass="13610" checksum="6B285CF6CCDC766D" modified="2016-06-08" version="1">MPNRWSGVTIDCADPSRLSLFWSELLDIPPTNEHGDDTNWATLGSRTSALPRLTFQRVPEPKSTKVRLHLDVQVDDISAGRRQVEALGGSWSGIRHDYDEGVVMVMLDPEGHEFCLVQYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTJ6</accession>
    <name>A0A132PTJ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ORF">AFM11_03605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844101.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21550"/>
    <dbReference type="EnsemblBacteria" id="KWX25372">
        <property type="protein sequence ID" value="KWX25372"/>
        <property type="gene ID" value="AFM11_03605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2596"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="30905" checksum="86E94D450FEDD479" modified="2016-06-08" version="1">MSIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQVVGGVNARKAGTKVSHKDKDGNDIELPVFGSVAEAMKETGADVSIAFVPPAFSKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNVEKGQKTRIIGPNCPGIITPGESLVGITPNNITGKGPIGLVSKSGTLTYQMMYELRDFGFSTAIGIGGDPVIGTTHIDAIEAFEKDPETKVIVMIGEIGGDAEERAADYIKANVSKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAAGVKVGKTPSETAAHARAILESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU69</accession>
    <name>A0A132PU69_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">AFM11_00515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842278.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33630"/>
    <dbReference type="EnsemblBacteria" id="KWX25814">
        <property type="protein sequence ID" value="KWX25814"/>
        <property type="gene ID" value="AFM11_00515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.106"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="23"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="27281" checksum="322D658D8E1B7133" modified="2016-06-08" version="1">MINLPGLRSRKVVAQRTPAELDAMAVAGALVAAALRAVRAAAAPGVSTLELDRVAESVIRDGGGTPSFLGYHGFPASICASVNDRVVHGIPSASEVLAAGDLVSIDCGAIVDGWHGDSAVTFGVGTLIDADEALSAATKAAMEAGIAAMVPGNRLTDVSHAIEVETHAAEARHDRKYGIVAGYGGHGIGRQMHMDPFLPNEGSPGRGPYLAPGSVLAIEPMLTLGTTKTVVLEDEWTVVTADGTRAAHWEHTVAVTDDGPRILTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU92</accession>
    <name>A0A132PU92_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842481.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33935"/>
    <dbReference type="EnsemblBacteria" id="KWX25883">
        <property type="protein sequence ID" value="KWX25883"/>
        <property type="gene ID" value="AFM11_00900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.186"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="106" mass="11590" checksum="E6B04DEBED933C8F" modified="2016-06-08" version="1">MAQSSNSLGTDFDVMTTVAGKIDVLNDDIRAMLQTFIGRMSSVPPSVWGGVAATRFRDVVDRWNSESLKLHTALQRIADTIRSNEQTLRDAADTHSQRLGAVGDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUF5</accession>
    <name>A0A132PUF5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_01280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34315"/>
    <dbReference type="EnsemblBacteria" id="KWX25943">
        <property type="protein sequence ID" value="KWX25943"/>
        <property type="gene ID" value="AFM11_01280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.262"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="171" mass="18580" checksum="29D49B5AA45723C6" modified="2016-06-08" version="1">MVAATLAGAAELFAERGPAGTSIRDIATRANVNHGLVYRHFGTKERLVGAVLEHLGARLTALLGDGAEADEIERTIDQHTRVMARALLDGYPVGQLQTRFPGVALLLDEVVPKFDDERRARMAVANAVALQLGWRLFEPFLRSAAGIEEVSRADVQQSVSAEIARILEPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUQ5</accession>
    <name>A0A132PUQ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01755</name>
        <name evidence="3" type="ORF">AWC31_34505</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842902.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34505"/>
    <dbReference type="EnsemblBacteria" id="KWX26004">
        <property type="protein sequence ID" value="KWX26004"/>
        <property type="gene ID" value="AFM11_01755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11773">
        <property type="protein sequence ID" value="ORX11773"/>
        <property type="gene ID" value="AWC31_34505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.361"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="213" mass="23716" checksum="787CEF469AF79188" modified="2016-06-08" version="1">MTLDLTVDELLTTTRSVRKRLDFEKPVSREVLMECLDLALQAPTGSNAQGWQWVFVEDPAKKKALADIYRTNANPYLDLPKPERGDIRDEQIDAVTSSAKYLNENFEKAPVLLVPCLEGRPDGAPAGMSASYWGSLLPAVWSFMLALRSRGLGSAWTTLHLLGDGEKQAAEVLGIPFDQYAQAGLFPIAYTKGTDFKKAKRLPAEQFAHWDTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVP5</accession>
    <name>A0A132PVP5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_01285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843614.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34320"/>
    <dbReference type="EnsemblBacteria" id="KWX26237">
        <property type="protein sequence ID" value="KWX26237"/>
        <property type="gene ID" value="AFM11_01285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.263"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="9">
        <location>
            <begin position="16"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="7">
        <location>
            <begin position="327"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="8">
        <location>
            <begin position="698"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="361"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="590"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX26237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="784" mass="86892" checksum="D3FE9550F54CDF34" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB44</accession>
    <name>A0A132PB44_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859628.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19561">
        <property type="protein sequence ID" value="KWX19561"/>
        <property type="gene ID" value="AFM11_35045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5738"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="181" mass="20382" checksum="B21AF5294ED00833" modified="2016-06-08" version="1">MLPKLGPDGMLPPGRYRVTQDEVQARFVDGRGPHRAELWRDWEVTTRMLGRRVPLNAAWLYGPFLSGADNPDTLQCVYWAEDYELGKARLDPAVAKLLRAFALPGEVRRAVGVKVDTALAAWHCQPDMRNRDEYFAQYTTRRGEVDDLLQRVASGPRGAAPVREDAVPRRGYVEVIIGGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB56</accession>
    <name>A0A132PB56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859731.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19546">
        <property type="protein sequence ID" value="KWX19546"/>
        <property type="gene ID" value="AFM11_35235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5778"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="75" mass="7984" checksum="97E602DAE6DD218F" modified="2016-06-08" version="1">MPDSAGDALHGGAPDAAGSALPLRKRQQKVPLNTYVRPGTQQRVEVLKDRGYAVTDIVDAALNEFLDRAGVPQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBU6</accession>
    <name>A0A132PBU6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859003.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02430"/>
    <dbReference type="EnsemblBacteria" id="KWX19764">
        <property type="protein sequence ID" value="KWX19764"/>
        <property type="gene ID" value="AFM11_33980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5133"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="285" mass="30002" checksum="CF79A552AA17578E" modified="2016-06-08" version="1">MTASTFVPPLLAPLVRLYRSTSTPVIRLGHMLVFFVQAVVAVPIALRHYRKEFVRLLSDITWGNGSLVVGGGTAGVAIVLGVTVGALVGIEGYNFLDLLGLGPATGIISSLVNTRELAPIAASLAFATQAGCRFTAQLGSMRIAEEIDALNALAIRPIPYLVTTRLMASVVAIVPLYVACLAVSYLTSQLVVFAISGGSTGSYLHYFTMMLSGQDILYSLLKAIVFVWIASTIQCYYGFYASGGPVGVGVAAGHAMRASITVVIMVNMLLTMALWSVDSGARFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBZ2</accession>
    <name>A0A132PBZ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858897.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07550"/>
    <dbReference type="EnsemblBacteria" id="KWX19836">
        <property type="protein sequence ID" value="KWX19836"/>
        <property type="gene ID" value="AFM11_33835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5105"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="369" mass="41538" checksum="BE977F88B5825DF6" modified="2016-06-08" version="1">MTEAIDKIWTTPPIPYRPELENPPADEEQLINKIMAKLLKNNQRAYEKYKHGLRDAHAKSHAILRGELIVNDDLRPELAQGIFAEPRRYPVIARISSTSGVLRGDKMRGVRGLGIKAIGVDGERLPEDEPSTTQDFVLVTHEDFLFADARAYAGLGMFTASLLARLPDTALWAGSELLSGLDKLGLHIPANLKVFIAPNRPILGETFFSSAPIRYGDYVAKFRYAPSSENVKAHAGELLPRNPSQDAHRDLIMEFFENNTAEYEFGVQLCIDEKTMPIEDASVNWDQKKSPYLPVARIVFPPQNPYSPLRRAYGDDVLSFNSWRGLKAHQPLGSINRLKKLVYESSSNFRHDVNRVPRHEPSDISELPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBZ9</accession>
    <name>A0A132PBZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19848">
        <property type="protein sequence ID" value="KWX19848"/>
        <property type="gene ID" value="AFM11_33635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5061"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452968" evidence="1">
        <location>
            <begin position="24"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="221" mass="22534" checksum="7763A8825625966B" modified="2016-06-08" version="1">MQRSRPVIGLISAVQAAIPPAQAAIRELLPSATLWNVLDDRLLDDAEGAITEALAARMRRLIDHTVLEGADAVLLTCSMYASVARDAAAEVDVPLFGPDEALFSAAAHGGYRRLALVSPALDPLADSLARIRPVVGTDVAVEAVVAEGAAAAARGGDVSALADAIIRAVSPVAGKIDAVVLGQYSLAPAAAGVQTALRLPTLAGPRYAAHALRVVLDGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCC8</accession>
    <name>A0A132PCC8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858701.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19887">
        <property type="protein sequence ID" value="KWX19887"/>
        <property type="gene ID" value="AFM11_33450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5021"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="22150" checksum="ED9E6B7D1D0E3575" modified="2016-06-08" version="1">MSWQPPYAEPGELARFMGDAAATDNAELVLAIETASRSVDRICNRQFGKTETLETRYYTARFDRNRRRWIIDVDDFATVDGLIAETVGAQYDSEITGYLPAPVNAVLDGKVWTQLVVDPASSAVPDATEHGVRVTATWGWPAIPPTIKLATLIQASRLFSRRHAPFGVAGNPEVGQLRLLERLDPDVAISVRPFARVWGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCQ3</accession>
    <name>A0A132PCQ3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 9">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_32595</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 9"/>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858161.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19730"/>
    <dbReference type="EnsemblBacteria" id="KWX20096">
        <property type="protein sequence ID" value="KWX20096"/>
        <property type="gene ID" value="AFM11_32595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4847"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="11">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="132"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX20096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="443" mass="46794" checksum="6C4B9AD68655F054" modified="2016-06-08" version="1">MTVALLTDKYELTMLAAALRDGTAHRQTTFEVFARRLPEGRRYGVVAGTDRFVEALAEFRFDQPSLAALADFLDSESLDYLAGYRFTGDVEGYAEGELYFPGSPVLSVHGTFAECVVLETLVLSIFNHDTAIASAAARMASAAQGRPMIEMGSRRTHEQAAVAAARAAYLAGFAGSSNLEAQRRYGVPAMGTAAHAYTLLHTTAAGPDEQAAFRGQVAALGVDTTLLVDTYDITRGVENAIAAAGPELGAVRIDSGDLGVLARQVRQQLDELGATKTRIVVSGDLDEFAIAALRAEPVDSYGVGTSVVTGSGAPTASMVYKLVEVDGMPVAKRSSHKESHGGRKQALRLAKASGTIVEEVVYPHGQPPEPQPGLTARQLSVPLVKGGRPVDDTDAADKLAAARDRVAAGLHSLPWDGLKLSRGEAAIPTRMVPSVVEHRGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCY4</accession>
    <name>A0A132PCY4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857867.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31840"/>
    <dbReference type="EnsemblBacteria" id="KWX20176">
        <property type="protein sequence ID" value="KWX20176"/>
        <property type="gene ID" value="AFM11_32055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4737"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="22110" checksum="1BEF35EFC14BE4BF" modified="2016-06-08" version="1">MPTGRDRLLAAALKLFAAKGYAATSVAEIQQESGLAPGSGALYKHFGSKRELLEAAVTHRIDSIVAAREEFDSGKPRSVEDAVRSAGELIWTNLTQSEELLRVMLREPHELGELDQKTWQVITDNAYQRFADELTASNRAGRTNIPDPEASAAVAIASLSYAATLRALTGRSPGNVDHDRYFEAWVVQTVSLIEQHRLHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCZ9</accession>
    <name>A0A132PCZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_31250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857414.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25400"/>
    <dbReference type="EnsemblBacteria" id="KWX20221">
        <property type="protein sequence ID" value="KWX20221"/>
        <property type="gene ID" value="AFM11_31250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4155"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="373"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX20221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="459" mass="49751" checksum="BD947DAC2BC3DD93" modified="2016-06-08" version="1">MPKMRPYHVAIVGSGPSGFFAAASLLKFAESPDADRDVRVDMLEMLPTPWGLVRSGVAPDHPKIKSISAQFEKTAADPRFRFFGNIAVGEHVQAAELAEQYDAVVYAVGAQSDRALKIPGEDLPGSVAAVDFVGWYNAHPHFGEMAPNLSGGRAVVVGNGNVALDVARILVSDPKALANTDIADHALESLGAQGMEEVVVIGRRGPLQATFTTLELRELHDLDGLDDVDVILDPADFADITDEDLEAAGKTVKQNIKVLRGYAEQGPRGAKRRIVFRFRTSPIELRGDGRVESIVLGRNELVRDADGRVVAKDTGDREELPVQLVVRAVGYRGVPTPGLPFDERSGTIPHTDGRVDGSANEYVVGWIKRGPSGVIGSNKKDSQDTVNTLLDDLHSRELRDFGPDHDEKLVAWLLERQPKLVTGDHWKLIDSHERAAGEPTGRPRVKLASVAELLRIGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD00</accession>
    <name>A0A132PD00_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857861.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31850"/>
    <dbReference type="EnsemblBacteria" id="KWX20174">
        <property type="protein sequence ID" value="KWX20174"/>
        <property type="gene ID" value="AFM11_32045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4735"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="408" mass="43002" checksum="5F34C689E94F56B3" modified="2016-06-08" version="1">MTSTTAGPLNGVKVVDMTTSYAGPTAAMYLADLGATVVKVERPGHGDDARGWGPPFVDGTSAWFASANRNKQSLVLDLRTDGGRDVLSRLLDTADVFLQNMNPAKLVRMGIDADTLHARNPRLVYCAMSGFGLDGPDSDLPGYDLVAQARSGLMSVTGEKGRSPQRVSTALSDVVTGMCAAIAISAALVRQTRSGEGETIDVSLLDTDLALMAPRIAAFHAGEPEPAPSGGTDSVLAVYQPFEAADRTIVVAIGNDAMWQRFCAAVDLPDLAADPALADNAGRRAHRSRITAVIAERLATRTAADWVRILGEVDVPVSLVQTLSEVVKDPQVVSRGSLMPVPESAERLVTVRSPFRLGGVAVRNERFPDLGADSRRILEELGYGSDDIAGLLAVGAVAEPDLTREAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDC5</accession>
    <name>A0A132PDC5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_31695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857712.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26315"/>
    <dbReference type="EnsemblBacteria" id="KWX20316">
        <property type="protein sequence ID" value="KWX20316"/>
        <property type="gene ID" value="AFM11_31695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4243"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="255" mass="27960" checksum="A224CF02456E3672" modified="2016-06-08" version="1">MPAHRIRQPRVAEIVASKLRDDILSGRLCEGDILPTQESLFQQFGVSPPALREAIHLLETDGLVSVRRGNMGGAVIRQPSAERTAHTISMVLQSRAATPADVSEALLHLEPICAGMCAARTDRATEVVPYLQAEIDTHTAQFGDTSRFVPNARRFHEVLVARCGNEPMILLIGSLELIWSAHESSVWGGEVDDAMNEKTMRAALRDHQRLLDAIADGDYARATKLAADHLTTARRTTLAVGTDRTIEARLISNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDQ2</accession>
    <name>A0A132PDQ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20458">
        <property type="protein sequence ID" value="KWX20458"/>
        <property type="gene ID" value="AFM11_30230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3942"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="117" mass="11550" checksum="D58FDAE4121545CE" modified="2016-06-08" version="1">MPLMPAVQRHIELQPEPVTAANATTTGVIATTGAMAATAGPTGAATAGATAATTVAFPGWAPVAAIAATGEGQLQTVFAALSGRGVRIARKNSEAVTAAVETNESNRQSLTVIPVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDV2</accession>
    <name>A0A132PDV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857331.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26880"/>
    <dbReference type="EnsemblBacteria" id="KWX20407">
        <property type="protein sequence ID" value="KWX20407"/>
        <property type="gene ID" value="AFM11_31170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4138"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="50"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="28172" checksum="29818CB796ECF014" modified="2016-06-08" version="1">MSAFVGDPGNALPLTGERTIPGLAEENYWFRRHEVVYQRLADRCIDRDVLEAGCGEGYGADLIADVARNVIGLDYDEATVAHVRARYPRVDIRHGNLAELPLADNSVDVVVNFQVIEHLWDQAQFAAECYRVLRPGGVFLVSTPNRITFSPGRDTPLNPFHTRELNAAELTELLVTAGFTLESMLGVFHGAGLTVMDERHGGSIIEAQVQRAVADAPWPDQLLADVAAVRTDDFDLTPAGERNIDDSLDLVAIAVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE48</accession>
    <name>A0A132PE48_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857477.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25535"/>
    <dbReference type="EnsemblBacteria" id="KWX20242">
        <property type="protein sequence ID" value="KWX20242"/>
        <property type="gene ID" value="AFM11_31380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4182"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="805"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="872" mass="92280" checksum="93357E69CE53322D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEG0</accession>
    <name>A0A132PEG0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_29320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040634.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20715">
        <property type="protein sequence ID" value="KWX20715"/>
        <property type="gene ID" value="AFM11_29320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3752"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1232" evidence="6">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="151" mass="16312" checksum="E03256889EC51FE1" modified="2016-06-08" version="1">MTGSFGWDLLIGVGGALLFAWLALLVALAILRPRGGLLREAVRILPDVLRLVRRLAGDSTLPRGIRVRLGLLLAYLAIPIDLIPDFIPVLGYADDAIIVAAVLRSVVRRAGLDTVRAHWPGTDDGFTALTRLTGLAKPSSRQHRDVPPQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEK3</accession>
    <name>A0A132PEK3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856096.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20768">
        <property type="protein sequence ID" value="KWX20768"/>
        <property type="gene ID" value="AFM11_28390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3553"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453186" evidence="2">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="69" mass="7273" checksum="8087512E41A485B2" modified="2016-06-08" version="1">MTITRRVAAGFTLAAAPALIFLGAATANAETSQTTTGPTVTHHEAFPNQSHVPEPGTSAHHHHQRNHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEM1</accession>
    <name>A0A132PEM1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856133.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32735"/>
    <dbReference type="EnsemblBacteria" id="KWX20780">
        <property type="protein sequence ID" value="KWX20780"/>
        <property type="gene ID" value="AFM11_28475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3573"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD_N" evidence="2">
        <location>
            <begin position="37"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="1">
        <location>
            <begin position="147"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="501" mass="55165" checksum="E3AC59E1D3EB4DE2" modified="2016-06-08" version="1">MSLSRRTVLRGAVALAALPAAGFTADRRLRSGDPFTLGVASGEPSSDGVVIWTRLAPDPLADDGLGSMPARAVDVEWEVAADERFTRIEQRGIVPAAPEYAHSVHVELAGLRPGRDYFYRFRAAGHLSPAGRTRTAPESGSLAPLSLCVASCSNYEQGWFTAYRRLAEEHSDLVVHLGDYQYEYAARDGGVRRHVGPETISLANYRRRHAQYKTDPDLQAAHASAPWVVVFDDHELADNWAGDVPALSQQGFMDRRAAAMRAYYENMPLRRSSLPRGADMQLYRRVHWGALATFHMLDTRQYRTDQACGDKISDCVDGLDPARTLTGDAQERWLLNGFQQSRARWDVLGQQVFFSQVDLTPGPGRGINPDAWDGYAANRDRIVAGLVDSPVRNAVVLTGDIHSHWAAEVRDRSGTAVATELVTTSISSGGDGSADTRAAVRAENPHIRYFADRRGYIRARISADELRADFRELPYVTRPGAAVHTGASFVVPDRERALHAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEY3</accession>
    <name>A0A132PEY3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_28380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856090.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32660"/>
    <dbReference type="EnsemblBacteria" id="KWX20767">
        <property type="protein sequence ID" value="KWX20767"/>
        <property type="gene ID" value="AFM11_28380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3551"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031326">
        <property type="term" value="P:regulation of cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX20767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="599" mass="63291" checksum="D449B726313C2A2A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF60</accession>
    <name>A0A132PF60_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856675.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25360"/>
    <dbReference type="EnsemblBacteria" id="KWX20632">
        <property type="protein sequence ID" value="KWX20632"/>
        <property type="gene ID" value="AFM11_30020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3896"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="22475" checksum="6FDA77F1CE516750" modified="2016-06-08" version="1">MPTPEQITRHHDPDPDENPWVEGPPSPELIELVPYNPQWPARYDTLAADIRAAMGSDLLDLEHVGSTAVPGLAAKDVIDIDLTVADPRDEEAYVPRLQTVGYRLTIREPGWHEHRCLRLDHPRVNLHVFGPDCPETIRHKLFRDWLRIHPDDRMRYEQAKRSAAPGGGHVMDYNLRKQPVIREIYDRIFRAHGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFA4</accession>
    <name>A0A132PFA4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855207.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06745"/>
    <dbReference type="EnsemblBacteria" id="KWX21018">
        <property type="protein sequence ID" value="KWX21018"/>
        <property type="gene ID" value="AFM11_26895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3253"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="475"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="545" mass="58933" checksum="CB06DA4C913ADD0E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFU3</accession>
    <name>A0A132PFU3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855021.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22705"/>
    <dbReference type="EnsemblBacteria" id="KWX21229">
        <property type="protein sequence ID" value="KWX21229"/>
        <property type="gene ID" value="AFM11_26630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3197"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="254" mass="27465" checksum="39DEB8B9991D1D13" modified="2016-06-08" version="1">MTGPNEQLEPQRRTLKIEIAVVLAVTFGLSAYTALLKLTEGVLLGLSGQTVALNPRRSPFDLIDLGLHLAGILQLLAWGALAIYLLWRSGFGPSTIGLTRPQWRADGLGGLGLAALIGLPGLAFYVVARVLGLSANVEPAELYDTWWRIPVLLGAAFANGWAEEIIVVAFLLTRLRQLDVSPARALVISSLLRGAYHLYQGYSAGLGNIVMGLVFGYVWQRTGRLWPLIIAHALIDAVAFVGYALVADRLGWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFW0</accession>
    <name>A0A132PFW0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_26425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854913.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22890"/>
    <dbReference type="EnsemblBacteria" id="KWX21193">
        <property type="protein sequence ID" value="KWX21193"/>
        <property type="gene ID" value="AFM11_26425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3154"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="PTHR45724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="259" mass="26871" checksum="E7AE43B91E763B0C" modified="2016-06-08" version="1">MYTPTMTHRLAAEFIGTFWLVLGGCGSAVFAAKFVADDGISLGIGFLGVSLAFGLTVLTGVYAFGVVSGGHFNPAVTLGAALARRVEWKAVVPYWITQVVGGLVAGLVIYVIAKGQDGWTATGNMAANGYGDNSPGGYSLVAVLIAEIVLTGIFLLVILGSTDDRAPKGFAGLSIGLTLTLIHLISIPISNTSVNPARSTAVAFFNGDGAPAQLWVFWLAPLIGAAIAGLAYPYLFGVAEELADRPVRDDALEPPDQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFX0</accession>
    <name>A0A132PFX0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="8" type="ORF">AFM11_27450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855474.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07385"/>
    <dbReference type="EnsemblBacteria" id="KWX21107">
        <property type="protein sequence ID" value="KWX21107"/>
        <property type="gene ID" value="AFM11_27450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3364"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="331" mass="35687" checksum="A7F6DA93D255C62E" modified="2016-06-08" version="1">MVHDSPDPQEHGHIPVLLERCVELLAPALTRRDADGTDAVLVDATLGAGGHSERFLTDFPGLRLIGLDRDPNALAIAGARLAPFGDRVTLVRTRYDGIASALADSGVPRIDGVLFDLGVSSMQLDQAQRGFSYATDAPLDMRMDPDAPLTAAEIVNTYDAKSLARVLRDFGEERFAGRIADKIVRRRASQPFTTTGELVELLYEAIPAPARRTGGHPAKRTFQALRIAVNGELDSLRIAIPAALGALQPGGRIVVMAYQSLEDRIVKQAFSTVTASRTPPGLPIELPGHEPEFVALTRGAERADEQEIERNPRSAPVRLRALEKVGGRGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFX2</accession>
    <name>A0A132PFX2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855663.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20882">
        <property type="protein sequence ID" value="KWX20882"/>
        <property type="gene ID" value="AFM11_27685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3411"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="52"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="202" mass="21853" checksum="CD93087A00125F79" modified="2016-06-08" version="1">MVEQSIWMRKVEADPGHSQWYVERFRSLARAGEDLAGEARLIDAIAPRAARILDAGCGPGRLGGHLFEAGHDVVGVDVDPALIEAAEQDHPGPRWLVGDLAELDLPARGIAEPFDVILSAGNVMTFLAPSTRVEVLARLRAHLRSDGRAVIGFGAGREYAFDQFLDDADAAGFTPDLLLSTWDLRPFTDDADFLVAILRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG35</accession>
    <name>A0A132PG35_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854437.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24675"/>
    <dbReference type="EnsemblBacteria" id="KWX21306">
        <property type="protein sequence ID" value="KWX21306"/>
        <property type="gene ID" value="AFM11_25605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2984"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="98" mass="10757" checksum="F5E424A125C03676" modified="2016-06-08" version="1">MPAVTEEQVETVRGLVAAIPAGRVSTYGDIADAAGLSSPRIVGWIMRTDSSDLPWHRVITASGRPAPHLATRQLERLRTEGVLAADGRVPLREYRHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG39</accession>
    <name>A0A132PG39_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_25520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854395.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24760"/>
    <dbReference type="EnsemblBacteria" id="KWX21291">
        <property type="protein sequence ID" value="KWX21291"/>
        <property type="gene ID" value="AFM11_25520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2967"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="391" mass="42615" checksum="2CD3C006E5048D9F" modified="2016-06-08" version="1">MSSTKLTAEEETIVKTVHDFVEKQVKPVVRELEHANTYPEELIETMKEIGVFGLAIPEPYGFGAVSMPCYVQVAEELARGWMSLAGAMGGHTVVSKLLLLFGTEDQKQKYLPRMATGELRATMALTEPGGGSDLQAMRTVARRGNEAGDGYVINGSKTWISNARRSDLVALLCKTDPDAHPPHKGVSILLVEKVPGFEISKDLPKLGYKGVESCELNFTDCHVPADALLGTEEGRGFAQMMKGLEVGRLQVAARATGVARAAFEDALRYAQDRESFGKPIWQHQSVGNLLADMGTKLYAARSLLLSAAEKFDAGERCDMEAGMAKLFASETAMQIALDAVRVHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAKQLVARGGLDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGE1</accession>
    <name>A0A132PGE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma factor, family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854518.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36125"/>
    <dbReference type="EnsemblBacteria" id="KWX21334">
        <property type="protein sequence ID" value="KWX21334"/>
        <property type="gene ID" value="AFM11_25770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3018"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024020">
        <property type="entry name" value="Anit_sigma_mycothiol_RsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014295">
        <property type="entry name" value="Anti-sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02949">
        <property type="entry name" value="anti_SigH_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03988">
        <property type="entry name" value="antisig_RsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="101" mass="11460" checksum="EFD9B52D31A59F27" modified="2016-06-08" version="1">MSESRESDERWSPPIGPVDPEHPDCAAVIAEVWTLLDGECTPESRDKLKHHLEECPACLRHYGVEERVKRLIAAKCSGEKAPDSLRERLRIEISRTTIIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHD2</accession>
    <name>A0A132PHD2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_23105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853015.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27870"/>
    <dbReference type="EnsemblBacteria" id="KWX21750">
        <property type="protein sequence ID" value="KWX21750"/>
        <property type="gene ID" value="AFM11_23105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1973"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="7">
        <location>
            <begin position="33"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="304" mass="34383" checksum="966072C564258FF4" modified="2016-06-08" version="1">MTVTDLVHVDELRLLEAEAVHIIREVVAELQRPVLLFSAGKDSIVLLRLAEKAFRPSPLPFPVMHVDTGHNFPEVIEFRDRRVTGAGHKLIVASVQETIDSGRVADPGPGASRNRQQTRTLLDALEAGGFDAAFGGARRDEERARAKERILSFRDEFGQWDPRAQRPEPWSLYNGRIRKGEQVRVFPLSNWTELDIWRYIQLENLELPSIYFAHEREVFERDGILLAVSDYAQPQGSEAATVEWVRYRTVGDLTITGAVRSQATDIERVITEISAATVSERGETRADDRTSAAAMEDRKREGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHF6</accession>
    <name>A0A132PHF6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_23335</name>
        <name evidence="12" type="ORF">AWC31_28060</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853133.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28060"/>
    <dbReference type="EnsemblBacteria" id="KWX21788">
        <property type="protein sequence ID" value="KWX21788"/>
        <property type="gene ID" value="AFM11_23335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14989">
        <property type="protein sequence ID" value="ORX14989"/>
        <property type="gene ID" value="AWC31_28060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2022"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="10">
        <location>
            <begin position="10"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="408"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX21788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX14989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="438" mass="45419" checksum="173D0B5A39983A92" modified="2016-06-08" version="1">MQEIDPAATAWLLASTALVLLMTPGLAIFYGGMVRTTGVLNMIMMSFISIPLVTVAWLLVGYTLAFSEDAGGGLIGGLQHFGMLGIDPTTARGSVPELLFATFQLSFAIITAALISGAIADRARFAAWMVFVPVWAVAVYAVVAHWVWGPGGWLFELGVLDYAGGLVVEIVSGASALALALVLGPRIGFKKDAMRPHNLPFVLLGVGLLWFGWFGFNAGSALAANGTAAAIFLNTLVAGCLGMLGWLTVEQIRDGKPTTFGAASGVVAGLVAITPSCGTVNTLGAVVVGLAAGIVCSFAIGLKFRFGYDDSLDVVGVHFVGGVVGVLLIGFLATEVMTAGPEGLLYGGGLAQLGKQLLAAVVVAVYAFAMSYAVAKVIDRFMGFRVSAEDETTGVDFTQHAETAYAEGVHGHSPLRRPGLFDGPLGERPKSLEDDQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHK8</accession>
    <name>A0A132PHK8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25110</name>
        <name evidence="3" type="ORF">AWC31_27430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854155.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27430"/>
    <dbReference type="EnsemblBacteria" id="KWX21492">
        <property type="protein sequence ID" value="KWX21492"/>
        <property type="gene ID" value="AFM11_25110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14881">
        <property type="protein sequence ID" value="ORX14881"/>
        <property type="gene ID" value="AWC31_27430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2383"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX14881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="245" mass="26906" checksum="A4BE53FEAEB63F9A" modified="2016-06-08" version="1">MYRVFEALDELGAIVEEARGVPMTAGCVVPRGDVLELIDDIKDAIPGELDDAQDVLDARDSLLREAKEHSESVMSKVNADADGMINHARAEADRLLADAKAQADRMVAEARQHSERMVVEAREEAARMSAAAKREYEASTGRAKAEADRLIENGNISYEKAIQEGIKEQQRLVSQTEIVATANAEATRVIDAAHAEADRLRGECDIYVDSKLAEFEEFLNGTLRSVGRGRHQLRTAAGTHDYATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHN6</accession>
    <name>A0A132PHN6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853310.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28390"/>
    <dbReference type="EnsemblBacteria" id="KWX21846">
        <property type="protein sequence ID" value="KWX21846"/>
        <property type="gene ID" value="AFM11_23670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2090"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453298" evidence="1">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="30794" checksum="3932761B83E8BCEE" modified="2016-06-08" version="1">MRALIGAVTAMLLVVTATVTGCSSDDKPESTYEAQTASLGESLNLLGWTITTSNLRFDAEHVLVDVEATASGGERAKPEDIRFGLYGALAHPIEANAIGGCAGVTSLALRPLSAPSPDKLSGTVCLGPLRDQSQVRGVYAYSPRERIAGTTVAYAAAFPVGVLPTNVNDTGLTIKTSSVDGFSADGAQLAPTALGEPDAFTGNGYMLLGLEIDGLAARYREDSARRGGPLMVVAAPTLPPPGLSHACSVYGASVLVLPDASRDAVNLRASLCTQGEINAALLYATVSLIGTQAALWTTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHW2</accession>
    <name>A0A132PHW2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="15" type="ORF">AFM11_22415</name>
        <name evidence="16" type="ORF">AWC31_08795</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852718.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08795"/>
    <dbReference type="EnsemblBacteria" id="KWX21925">
        <property type="protein sequence ID" value="KWX21925"/>
        <property type="gene ID" value="AFM11_22415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10245">
        <property type="protein sequence ID" value="ORX10245"/>
        <property type="gene ID" value="AWC31_08795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1833"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="121"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX21925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX10245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="347" mass="38090" checksum="D5F5F6A5B2F5E371" modified="2016-06-08" version="1">MAEQPSDLSEEALTKAVSAARHAFDLAGDLDALARAKTEHLGDRAPIALARQALATLPKADRADAGKRVNVARGEAQRAYDERLAVLRAERDAAVLVAERIDVTLPSTRQPIGARHPITILAENVADTFVAMGWELAEGPEVETEQFNFDALNFPPDHPARSEQDTFQIAPDGSRQVLRTHTSPVQIRALLERELPVYIVSIGRTFRTDELDSTHTPVFHQVEGLAVDKGLTMAHLRGTLDAFARAQFGPEGRTRFRPHFFPFTEPSAEVDIWFPNKKGGPGWVEWGGCGMVNPNVLRACGIDPDVYSGFAFGMGLERTLQFRNGIPDMRDMVEGDVRFSLPFGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI04</accession>
    <name>A0A132PI04_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852802.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08525"/>
    <dbReference type="EnsemblBacteria" id="KWX21966">
        <property type="protein sequence ID" value="KWX21966"/>
        <property type="gene ID" value="AFM11_22680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1886"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="25"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="400" mass="42213" checksum="CFFC142A6DF226D6" modified="2016-06-08" version="1">MSTPEPLYILGAGMHPWGKWGRDFTEYGVVAARAALAEAGLDWRQIQLVAGADTIRNGYPGFIAGSTFAQKLGWNGVPVSSSYAACASGSQALQSARAQILAGFCDVALVIGADTTPKGAFAPVGGERKNDPDWQRFHLIGAMNPVYFALLARRRMDLYGATAEDFAQVKVKNSRHGLQNPNARYRKESAVEDVLASPVVADPLRQLDICATSDGAAALIVASADFARKHLGSLEGVPSVRAISTVTPRYPQHLPELPDIATDSTAVVEAPERVFKDQILDAAYAEAGIGPEDVSLAEVYDLSTALELDWYEHLGLCAKGEGEQLLRSGATTIGGRVPVNPSGGLACFGEAIPAQAIAQVCELTWQLKGQATGRQVEGAKVGVTANQGLFGHGSSVVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIK0</accession>
    <name>A0A132PIK0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853269.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28320"/>
    <dbReference type="EnsemblBacteria" id="KWX21832">
        <property type="protein sequence ID" value="KWX21832"/>
        <property type="gene ID" value="AFM11_23595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2075"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012042">
        <property type="entry name" value="NeuTTM/CthTTM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40114">
        <property type="entry name" value="PTHR40114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016487">
        <property type="entry name" value="CYTH_UCP016487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="207" mass="22654" checksum="3A86B0CF5D60A9B8" modified="2016-06-08" version="1">MSDSGAGDFEFERKFFVREMPAVAASDPSPVLIVQAYLFASDGFAVRVRVQGTAPAELDTDPGRLVELLGEESIGTMTAKGPAVGGTRYEAERDLDPLVAAQIVRRADHVVAKIRYAMWLGEDGWIIDRFLGGNAPLVLAEVERGGPVVDLAIPAFCATEVSEDDRFRNEYLAHQPFGMWADSYLTELDRLGPRFVDTLGRNQFEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIM5</accession>
    <name>A0A132PIM5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_21390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04205"/>
    <dbReference type="EnsemblBacteria" id="KWX22208">
        <property type="protein sequence ID" value="KWX22208"/>
        <property type="gene ID" value="AFM11_21390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1625"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="31069" checksum="0DF3BA83445D7DE3" modified="2016-06-08" version="1">MVRRRDVRGAKRREQILNLLQTVESGSLSVEEIAERFGVSFATVRRDLSRLHQDRHITRTYGGVALTVPTELSIHQRHLEFTREKDAIGRLAAESVADGAVVIVDAGTTTEFVARYLDAEDLTVFTNGIGAINILMRKEDVSVVVLGGRLRRVNETISGAEAEHMLRAVVADYAFIGADAVHPRYGVASRTLEQSRLKTLMMQRARQTIVVADHRKLGTDQFSYWSELPAQWRFITDDGAETEAPATALDELRRIGAHIELAHPLRALTDTADERGTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ56</accession>
    <name>A0A132PJ56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852205.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06510"/>
    <dbReference type="EnsemblBacteria" id="KWX22333">
        <property type="protein sequence ID" value="KWX22333"/>
        <property type="gene ID" value="AFM11_21145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1576"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453391" evidence="1">
        <location>
            <begin position="27"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="461" mass="47253" checksum="6480972B8382AD22" modified="2016-06-08" version="1">MLDVLARRAVASGSLGAVSAGSRTAAAIGASAFLAGGNAFDAALAAALSETVALPSKCGLAGDVVALYVTAGASAPISLVAIGGASAGLYAAAEAAGWEVPATGPLSVGIPGAPAGYSRIAELARLPLERLTAPAVELARRGVWWSPMNATLECEARTLLYRYQPDGCVYSPRDAKHTVGDMVRLPGLAVVLEEFVARGADLFTGPVGDAVVDCVQRHGGMLTARDLVSVDVAEEAAHCVQTESGPLWATNAPTYGPALTHAMAGRVVSDVGPGDVRRSLADLADTKTAAAEGTSTVAAVDEAGNAVVLVHSLSFPQYGSGLVVGEYDLILSNRAGRGFTFAPGHPNAPVAGRRPLTTLHAWGIGHRDGWILGATPGGQQQVPWNVQLVAQLLDTSDDGEQAMGDALVTPRWQLDAPGDVRHEGRELGRFEARSSHTLVRTATSRCAAAADPRWDGAAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJJ9</accession>
    <name>A0A132PJJ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_20235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851926.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11480"/>
    <dbReference type="EnsemblBacteria" id="KWX22483">
        <property type="protein sequence ID" value="KWX22483"/>
        <property type="gene ID" value="AFM11_20235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1382"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="263" mass="27222" checksum="1D24A6B31F7DE03A" modified="2016-06-08" version="1">MLAAERRRAILRALNSGGAVRVAELAAQLAVSEMTVRRDLDAMDAEDLLRKVHGGAVTRHNRGEEPWSSVKAAQQRAEKAAIADVAAGMVADGVTIAISAGTTTTELARRLRHRPSITVVTNSLTVFDVLTAPSTDGADAPQVYLTGGTRTPSDALVGPIADAALALFRVDATYLGVHGFDPQAGLTSPNIAEAQTNRTLIGIGAQLVVLADHTKYGEIGTNVFAGLGQVDTLIVDDGLADEDRAALAGLVGDVVIAQVAGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJU0</accession>
    <name>A0A132PJU0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851537.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_14930"/>
    <dbReference type="EnsemblBacteria" id="KWX22573">
        <property type="protein sequence ID" value="KWX22573"/>
        <property type="gene ID" value="AFM11_18840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1103"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022468">
        <property type="entry name" value="PhnX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03351">
        <property type="entry name" value="PhnX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="24652" checksum="5DA7E03CF61D78FE" modified="2016-06-08" version="1">MSTNTNEPISLVVFDMAGTTVEDSGLVQQSFLAADSHAGLSKTDADREEMLRYVSDTMGQSKIVVFRHLARGNEEQAQAANKEFERCYSQLVAEGNCSAIPGAEDAITSLRSRGIKTALTTGFARETQTAIIDALGWHDLADLVLCPEPGMRGRPYPDMPLTALMRTETDSVRSMVVLGDTSSDVISGLRAGARASIGVLTGAHDKGQLADAGATHIIDSVADLPSLLATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK44</accession>
    <name>A0A132PK44_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-hydroxycyclohexanecarboxyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15310"/>
    <dbReference type="EnsemblBacteria" id="KWX22634">
        <property type="protein sequence ID" value="KWX22634"/>
        <property type="gene ID" value="AFM11_19230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1180"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="262" mass="27174" checksum="36BB3104FE079F79" modified="2016-06-08" version="1">MVSGGLDGKVAVVTGAGGGIGLACVRAFHAAGACVLGADIDTGGLAGIGGERVREARVDLRHPEDADAMVQAALDAFGRLDILVNNASIAPVRQGFLATTDEDWQRTLELNLLGYIRAARAAIPALQRAGGGVLIHVASEAARMPNPRLPDYSVSKSGVLMLSKVLAAEFTSQGIRSNVVSPAFIRSPIYDRPGGLADSLAEEFGVDKETALQKYVELNRIPVGRLGTVDEVASMVTYLATDDAAFISGSNFSVDGGVTPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK48</accession>
    <name>A0A132PK48_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19750</name>
        <name evidence="2" type="ORF">AWC31_11090</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX09022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851835.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11090"/>
    <dbReference type="EnsemblBacteria" id="KWX22392">
        <property type="protein sequence ID" value="KWX22392"/>
        <property type="gene ID" value="AFM11_19750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09022">
        <property type="protein sequence ID" value="ORX09022"/>
        <property type="gene ID" value="AWC31_11090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1284"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX09022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="202" mass="21691" checksum="2DCDB27869EB1735" modified="2016-06-08" version="1">MNVAPDELTGTEQAVLLVLMAESRPVPNPELERLGPKLDKPGRVRLNELGLIETTTGRPLVHELTDSGWALCRELLGAGAPARSSGQGRALYTVLNSLGRYFDRADLAPADVFLPPAQAEEQLRTAYTRLAARPGGWVSLVSLREAVPGLARAEVDAALVNLYQQPGVSLIPEENQKVLTAADRAAAVQIGDQNKHLMAIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKP4</accession>
    <name>A0A132PKP4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ORF">AFM11_17540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851074.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05060"/>
    <dbReference type="EnsemblBacteria" id="KWX22908">
        <property type="protein sequence ID" value="KWX22908"/>
        <property type="gene ID" value="AFM11_17540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.863"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="28"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="371"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX22908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="558" mass="59662" checksum="EE9F2C7A6C7E6265" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKT6</accession>
    <name>A0A132PKT6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_16375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850605.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19945"/>
    <dbReference type="EnsemblBacteria" id="KWX22956">
        <property type="protein sequence ID" value="KWX22956"/>
        <property type="gene ID" value="AFM11_16375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.623"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="264" mass="27798" checksum="FD5C4C6C9738AB80" modified="2016-06-08" version="1">MTESQPGAIVERNGNVLIITINRPEARNAVNSSVSIAVGDALADAQNDPEVRAVILTGAGDKSFCAGADLKAISRGENLFHPDHPEYGFAGYVSHFIDKPTIAAVNGTALGGGTELALASDLVVAEERAKFGLPEVKRGLIAGAGGVFRIAEQLPRKVAMELLFTGEPITAADALRWGLINQVVPDGTVLDAALKLAERITGNAPLAVQASKRVAYGAEDGGVPGDQPGWKRTNREFAILLQTEDAKEGPLAFAEKRQPVWKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKY3</accession>
    <name>A0A132PKY3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="7">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_16675</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850712.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01245"/>
    <dbReference type="EnsemblBacteria" id="KWX23006">
        <property type="protein sequence ID" value="KWX23006"/>
        <property type="gene ID" value="AFM11_16675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.685"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006468">
        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="14">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="850"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX23006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1224" mass="134979" checksum="0B191822BEF56AEC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL48</accession>
    <name>A0A132PL48_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_17035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850840.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01605"/>
    <dbReference type="EnsemblBacteria" id="KWX23069">
        <property type="protein sequence ID" value="KWX23069"/>
        <property type="gene ID" value="AFM11_17035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.760"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="380"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="498" mass="51221" checksum="9A0D15B59CD767DB" modified="2016-06-08" version="1">MTNQDQSGDSGRLAPRPVERPPVDAASQRTFGRPSGVDGSFLGADKYQDQGEYAPKDQPPDPVLAEAFGRPKGAADSLQRHPTDAGALDAERAGVDDDVDDPWRDPAASVALGTPAQAPSAPVIVSAPAGKLGLREVLFGGRVSWVALVVLILTALLVSFVGGWVGQKTAGTVEAFTTSKVTLETGDLPEPEAGRIASVAAAVADSVVTIEAKSNNEGSQGSGVVVDGNGYIVTNNHVISEAAGKPADYKITVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLTVARMGDSEKLRVGEEVIAAGAPLGLRSTVTHGIISALHRPVPLSGDGSDTDTVIDGVQTDASINHGNSGGPLINMNSEVIGINTAGKSLSDSASGLGFAIPVNEVKQVVETLIKDGKIAHPTLQLTAKSVSNSVASGAQIANVVAGGPADKAGILENDVVVKVGDRKVADADEFVVAVRQLKIGQEAPIEVVREGRPMTLMVTPIGDDQKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL65</accession>
    <name>A0A132PL65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16615</name>
        <name evidence="3" type="ORF">AWC31_01185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850685.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01185"/>
    <dbReference type="EnsemblBacteria" id="KWX22994">
        <property type="protein sequence ID" value="KWX22994"/>
        <property type="gene ID" value="AFM11_16615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13176">
        <property type="protein sequence ID" value="ORX13176"/>
        <property type="gene ID" value="AWC31_01185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.672"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="133" mass="14489" checksum="8A2C160AF7486E5C" modified="2016-06-08" version="1">MTSNERPPGSNARPAAARQRVVLAHRRGARMVRTRVEVQEQTQVGDALVRGLVRAQLGLALRLAAVVVSIVVAVLLLTTALPEVAGLSVFGIRLNWLILAGLIYPLLYGVGRLYVRLAEQGERDFVRVVDSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLC9</accession>
    <name>A0A132PLC9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Excalibur domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851009.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01320"/>
    <dbReference type="EnsemblBacteria" id="KWX23148">
        <property type="protein sequence ID" value="KWX23148"/>
        <property type="gene ID" value="AFM11_16750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.703"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008613">
        <property type="entry name" value="Excalibur_Ca-bd_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05901">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00894">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453376" description="Excalibur domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Excalibur" evidence="2">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="194" mass="18487" checksum="A9F953361559DE4E" modified="2016-06-08" version="1">MRTFIVGLACSAVVAPLLAVFTAPTAGAYPNCAAARAASAAPLYAGQPGYSSKLDRDGDGVACESGGGGGGGYAGGGLPLYGGAPVATAPTNQAPAAPPGAGAGFTTVVNWTGTDCIDITAPAADAGTLQTASYCGGQARLTSSGSGEQMVGADPVMGDAGTLACEILDGLLVDSGTAGDGHDVNCLTRASALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLG5</accession>
    <name>A0A132PLG5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureF</name>
        <name evidence="4" type="ORF">AFM11_15265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850167.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15885"/>
    <dbReference type="EnsemblBacteria" id="KWX23186">
        <property type="protein sequence ID" value="KWX23186"/>
        <property type="gene ID" value="AFM11_15265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7166"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="224" mass="23790" checksum="52E0A35AB6222621" modified="2016-06-08" version="1">MADPAAALAWLQLHDNAFPAGRFVHSYGVESWLQAHPAASDSEICRLAESFVRHSVATLDAVVVAHAWAVEELSALTALDALTTSYKLTANARAASHGCGRQFALVAQQVGVRAPFLGAVTGGRADGNLAVVEAVVQRELGIGRLDAALGSIRSGYAGVLSAAVRLGRLGPIRAQRALLDARRQMVEMARLALATPLDDMHSTTPELEIWAMRHETASGRMFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLH0</accession>
    <name>A0A132PLH0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_16800</name>
        <name evidence="11" type="ORF">AWC31_01370</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850758.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01370"/>
    <dbReference type="EnsemblBacteria" id="KWX23027">
        <property type="protein sequence ID" value="KWX23027"/>
        <property type="gene ID" value="AFM11_16800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13210">
        <property type="protein sequence ID" value="ORX13210"/>
        <property type="gene ID" value="AWC31_01370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.713"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX23027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX13210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="107" mass="11673" checksum="199E061195C8D603" modified="2016-06-08" version="1">MTYVIAEPCVDVKDKACIEECPVDCIYEGARMLYIHPDECVDCGACEPVCPVEAIYYEDDVPDQWSSYAQSNADFFSELGSPGGASKVGQTDNDPQAIKDLPPQGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLT3</accession>
    <name>A0A132PLT3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_16695</name>
        <name evidence="2" type="ORF">AWC31_01265</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851007.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01265"/>
    <dbReference type="EnsemblBacteria" id="KWX23147">
        <property type="protein sequence ID" value="KWX23147"/>
        <property type="gene ID" value="AFM11_16695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13192">
        <property type="protein sequence ID" value="ORX13192"/>
        <property type="gene ID" value="AWC31_01265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.689"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX13192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="145" mass="16255" checksum="9D6277DE961F22BE" modified="2016-06-08" version="1">MPKGQELDVLTRRQCLDLLQRVRVGRLVFTEDALPAVQPVNFRLTHDDVVIRVAGGAKLTAATENHVVAFQADELDPDLRTGWSVTVVGHAQPITDVDELVEVAGTFVQPWVDGRRDHFIRIRAEKVTGRQIREQSVPHYQGEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM05</accession>
    <name>A0A132PM05_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850460.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16665"/>
    <dbReference type="EnsemblBacteria" id="KWX23385">
        <property type="protein sequence ID" value="KWX23385"/>
        <property type="gene ID" value="AFM11_16090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7343"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453172" evidence="1">
        <location>
            <begin position="30"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="322" mass="35039" checksum="00CF9C8DBBBF9874" modified="2016-06-08" version="1">MTGRWMVVVMASLLLASGCAGNSATQSTAGTPPGFPLTLDNCGVTTTYDRPPTRAVALNQHAIETLLALGLEKSMVGTSYLDDRILPEYQAAYDSVPVLAEEYPSYEALLAVEPDFVYGGWDSAFDEKEGRARQRLADVGIDTYLNIEDCSSEPATMSTVDAELRGIGRIFGISDRAEEQVDQLHRDLERAESKVRGAAHVKVAVYDSGEATVFTSGGKGIGNEMITAAGGVNLFSDVPKVWADVSFEQFAERSPDVILIYDYGDQPVEQKKKFLMGHPLLQHVPAIRDERFAVLPLSSVVVGVRIARAVEALARQLHPERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMA0</accession>
    <name>A0A132PMA0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849804.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18450"/>
    <dbReference type="EnsemblBacteria" id="KWX23466">
        <property type="protein sequence ID" value="KWX23466"/>
        <property type="gene ID" value="AFM11_14370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6982"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="302" mass="32075" checksum="3C5D6E4B14CC5282" modified="2016-06-08" version="1">MTDPSRYPPGWNPPPPGPYQGQPPVNPYYYYQPGYNWPGYGEAPPIHGRPPKRSKTPWIIAAVAAVLVIAIVVGGVLWRFNSGGEDTEAATTTTSATTSTTATPECEGRVASPTPQTPPDWIAVASPRGLGYDVPPDWTVNSCTTMIGWEVPCPDGPFGFCPVRTMTGSAEMPNKQCPDLHRGATGVPGANSTDDIDEALQRETQLVEDIYTSRSGVVPTVSLGERRELTVSGEPAVQVIATVTGIEASECTGPSALHSMLATKVEGQPGSVMFIVSLEQGYPGAPDPKLIDEIVATLRKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMF9</accession>
    <name>A0A132PMF9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14300</name>
        <name evidence="4" type="ORF">AWC31_09055</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849779.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09055"/>
    <dbReference type="EnsemblBacteria" id="KWX23454">
        <property type="protein sequence ID" value="KWX23454"/>
        <property type="gene ID" value="AFM11_14300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09098">
        <property type="protein sequence ID" value="ORX09098"/>
        <property type="gene ID" value="AWC31_09055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6968"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="66"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="357"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="377"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="593" mass="65043" checksum="59A341A4430877A6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMH1</accession>
    <name>A0A132PMH1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxybenzoyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849662.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09510"/>
    <dbReference type="EnsemblBacteria" id="KWX23397">
        <property type="protein sequence ID" value="KWX23397"/>
        <property type="gene ID" value="AFM11_13960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6895"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="148" mass="16357" checksum="D491E2698A815CED" modified="2016-06-08" version="1">MTGTELTPGDFPLHWPVLTRWTDNDMFGHLNNAVYYELFDTAINGWINTNCDIDPVNAPWLGVVAESGCRYFAELKFPDPLVVGLSVARLGNSSVTYQLGLFEPDGPVAAVGHWVHVYVDRTTRRPVPIPDAIRALLQSICSADAARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMJ7</accession>
    <name>A0A132PMJ7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0232 protein AFM11_14745</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_14745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0232 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849932.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18155"/>
    <dbReference type="EnsemblBacteria" id="KWX23523">
        <property type="protein sequence ID" value="KWX23523"/>
        <property type="gene ID" value="AFM11_14745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7058"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00630">
        <property type="entry name" value="UPF0232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023007">
        <property type="entry name" value="UPF0232_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="188" mass="19934" checksum="C063CD7CFC2C518E" modified="2016-06-08" version="1">MTDDGDDTVQPFPPDHLAGLRGMDLVRRTLEEARGAARSQGKDVGRGRSAPVRRVAGAGRRRTWSGPGPDVRDPQLLGAATQDLAKSRGWSSRVAEGSVFGRWRSVVGDQIAEHANPTALHEGVLTVSAESTAWATQLRMVQAQLLAKIAAAVGDGVVTSLKIVGPVGPSWRKGPYHIAGRGPRDTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PML9</accession>
    <name>A0A132PML9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849910.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18210"/>
    <dbReference type="EnsemblBacteria" id="KWX23514">
        <property type="protein sequence ID" value="KWX23514"/>
        <property type="gene ID" value="AFM11_14690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7047"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="269" mass="27909" checksum="A7151C448A2076E7" modified="2016-06-08" version="1">MSTRAASAFALTDDELQVVGSRLGVTEFPTVLAVRPRHGTVEALARAADLATGQLAARGLIGSDGVDTELAEMVTALRRPAREIAIRLVTPDGLARISLVQTGFMCVAARRTGNGLQLRAIDSHTGIAGAVIAELPASQPAAVEPFSAPATDLAECLNGGHSATFFTDRLRALGAGHQVASALGSAFAARIAFAEIVCHVLDAAADRVVRVPGAVAVFYTKRGRLVSAPSVSPSGQLWTTIKPGSDHRVMQAISQLAELTPSGWEGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN94</accession>
    <name>A0A132PN94_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849298.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03540"/>
    <dbReference type="EnsemblBacteria" id="KWX23744">
        <property type="protein sequence ID" value="KWX23744"/>
        <property type="gene ID" value="AFM11_13255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6744"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="283" mass="29833" checksum="5D9114C2FAF9562C" modified="2016-06-08" version="1">MRTIFITGVSTGLGRAFATAALQSGDRVVGTLRKPAEVAAFEALAPGRAHARLLDVTDDAAVFRTVADIESEIGPIDVVIANAGYGLEGIFEETPLSAVRAQFATNVFGVAATLQAALPYMRRRRAGHLMAVTSMGGLMAVPGMSAYCASKFAVEGLLESLRKEVAGFGIHVTAIEPGSFRTDWAGRSMTRAERSIADYDALFDPIRTARVNASGNQLGNPAKAAQAVLSILDTDKPPAHLVLGSDALRLIAAARSAVDDDIRRWESLSRSTDFADGAQLASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN95</accession>
    <name>A0A132PN95_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_13645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849462.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03890"/>
    <dbReference type="EnsemblBacteria" id="KWX23806">
        <property type="protein sequence ID" value="KWX23806"/>
        <property type="gene ID" value="AFM11_13645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6825"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="406" mass="40858" checksum="A32FB3A6DF831787" modified="2016-06-08" version="1">MTTPEGLQRRLGTVDAVTIGLGSMIGAGIFAALAPAAAAAETGLLIGLAVAAVVAYCNATSSARLAARYPQSGGTYVYGRERLGEFWGYTAGWSFIVGKTASCAAMALTVGLYVWPDQAHAVAVAAVVALTVVNYAGVQKSALLTRIIVAVVLAVLAAVVVIVLGSGAADTARLELADDVTAGGVLQAAGLLFFAFAGYARIATLGEEVRDPARTIPRAIPIALGIALVVYAVVAVAALAVLGSAELASAPAPLADAVAAAGAGQWQPVVRVGAAVAALGSLLALILGVSRTTLAMARDHHLPHRLAAVHPRFGSPHRAEIVVGVAVAVLAAFADLRGAIGFSSFAVLMYYAIANASAWTLGRRVIPALGLVGCLVLAFTLPLSSVLTGLAVVAVGAAIYGVRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNB2</accession>
    <name>A0A132PNB2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amylo-alpha-1,6-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849132.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03200"/>
    <dbReference type="EnsemblBacteria" id="KWX23687">
        <property type="protein sequence ID" value="KWX23687"/>
        <property type="gene ID" value="AFM11_12915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6675"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="24"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="430"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="708" mass="77035" checksum="E7237F7B1290F2CE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNG2</accession>
    <name>A0A132PNG2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23833">
        <property type="protein sequence ID" value="KWX23833"/>
        <property type="gene ID" value="AFM11_13820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6860"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="PTHR43709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="348" mass="36159" checksum="DCD714FCB9637524" modified="2016-06-08" version="1">MSAHGVKCMLMRGGTSKGTYFLADDLPRDPGERDDLLLRIMGSPDPRQIDGVGGGHPLTSKVAVVSRNGAGVDYLFLQVSVDQALVSDRQNCGNLLAGVGPFAIERGLVAATDGQTAVPIRMTNTGGRAIAHVPTPAGVVEYAGTTSIDGVPGTAAAIVLDFEDTAGSSCGALLPTGQVQDVIAEVPVTCVDNGMPTVVLRAADLGVRGDESPTELESDQRLRELLERVRLEAGKRMNLGDVSDLTVPKLTIVSPPRSGGVIATRTFIPHRVHASIGVLGAASVAVAAALPDSVAAGIADPSGGPRMRIEHPTGALEVEVELDGERVRRTAIVRTARKLFDGTVFPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNQ6</accession>
    <name>A0A132PNQ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyrate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849503.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04025"/>
    <dbReference type="EnsemblBacteria" id="KWX23827">
        <property type="protein sequence ID" value="KWX23827"/>
        <property type="gene ID" value="AFM11_13785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6853"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="444" mass="46807" checksum="5B4FA4F11E3A8D45" modified="2016-06-08" version="1">MSFSNIMDSNSYTGGLATDPGTEQLISARTRLLGPAYRLFYERPVHLVRGRGSHMFDADGVRYLDAYNNVVSVGHCHPNVVSAVTRQLETLNTHTRYLHEGIVDYSARLLGTFADSGADDIDQVMYACTGSEANDLALRVAQMYTGATGVIVTGDAYHGNTEAVTAISPSLGGDTTVGPHVRTVPAPDSYRTGTAVAAKFRADVQAAITDLQAAGHGVRCLIVDTIFSSDGIYPDPSVLGPAVEAVRAAGGVFIADEVQPGFGRTGDSMWGFSRHGVVPDLVTMGKPMANGLPVAAMAARSEVLEAFARGVPYFNTFGGNPVSMAAAAAVLDVIEDEQLIANAARVGATLQDELARITAGHPRIGDVRGCGLYVGVEVVTDPETALPNRAAAHDLVNAMRDRRVLISVCGSDGNVLKIRPPLVFSMADVDWLCTEFGAALAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNW2</accession>
    <name>A0A132PNW2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848373.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30335"/>
    <dbReference type="EnsemblBacteria" id="KWX24020">
        <property type="protein sequence ID" value="KWX24020"/>
        <property type="gene ID" value="AFM11_11690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6415"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="108"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="439" mass="45609" checksum="773E0494DF823FF1" modified="2016-06-08" version="1">MPAAITPRIDELRAEGVEIVAGSLTDLAGVTRAKYIPLHRLSVFEQSGMGVSPSWSVFCVDSGIAFTPSIGVVGDQRIRIDPADLRLVEEKVAWAPASLYDQQGNPAPLCTRSLLADTERAAADRGLNVLVGAELECTMLAPDGGHATTANWSPYGIRTSLDKSAFLVDLNATAARAGLAVEQLHTEYGHDQLEVSLAPTTPVAAADAVVLARIVIGRVAARHGMTVSFSPVPFAGEAGNGAHLHLSLADDTGPLLSGGDGPHGMRSSGCSAVAGVLDGLPDLVGVYAGSVISAARLKPGNWAGAAKCWGLENREAAVRFIAATPGNPHGANVELKIIDPSANPYLAAAALLGSALRGIDKDLRLPAEVTDDPANSEARPLPADHRTVIELLESSAVAAEILTPAVVEGLAAVRRHELVTYGDRPPAETCQALRLAWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNW4</accession>
    <name>A0A132PNW4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13170</name>
        <name evidence="3" type="ORF">AWC31_03455</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849265.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03455"/>
    <dbReference type="EnsemblBacteria" id="KWX23732">
        <property type="protein sequence ID" value="KWX23732"/>
        <property type="gene ID" value="AFM11_13170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11192">
        <property type="protein sequence ID" value="ORX11192"/>
        <property type="gene ID" value="AWC31_03455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6727"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="50"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="183" mass="20469" checksum="B922B9539AF69D7D" modified="2016-06-08" version="1">MSALEPARIAPGGFRELGPINWAIAKLGARAIRAPRFTLFNVLGQHKLLFLAWLPYSGVLLGRLGKLPRKDAELIILRVGHLRDCEYELQQHRRLARSRGVDAETQAKIFEGPDAAGLTDRQRVLITATDEFVVTRSMSSETWATLSKHLNKQQLIEFCMLAAQYDGLAATMATLRMPLDFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP66</accession>
    <name>A0A132PP66_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848742.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09645"/>
    <dbReference type="EnsemblBacteria" id="KWX24136">
        <property type="protein sequence ID" value="KWX24136"/>
        <property type="gene ID" value="AFM11_12335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6546"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="147" mass="16358" checksum="6A5BB150964E8845" modified="2016-06-08" version="1">MADVADQQLRDLKLLRRVRDRIDREYAQPLNVEALARGVNMSAGHLSRQFKAAYGESPYSYLMTRRIERAMALLRRGDMSVTEVCFAVGCSSLGTFSTRFTELVGVPPSVYRRDATDVTAGIPSCLAKQVTRPIRNREASVYGSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPC0</accession>
    <name>A0A132PPC0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848451.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30210"/>
    <dbReference type="EnsemblBacteria" id="KWX24047">
        <property type="protein sequence ID" value="KWX24047"/>
        <property type="gene ID" value="AFM11_11835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6446"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="163"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="397" mass="43792" checksum="B9E97FEBE15BA67A" modified="2016-06-08" version="1">MARPLLPAAAELLNAVNAVKPLGRKGYTTVAAFAFGWPTSENAPLITTVSVADALRRGIRGDYRSAQGRISLVLKAISWALLYLIHRRGLASQPYFEDPLRTALGADYAVAPRPLRRGEVWSTSWSRRRYAQKTVHYGPHRANLADIWMRTDLPRDGKAPVLLQVPGGAWMIGMRRPQSYPLMSHLAEQGWICVSIGYRISPRHPWPDHIIDVKRALAWVKDNIASYGGDPDSVCITGGSAGGHLTALAALTPNDPKWQPGFEDADTSVVAAVPVYGRYDWFSTSGTGRSEFMEILQRLIVKLPLSGNEQVYRDASPITLVRPDAPPFFILHGVNDSLIPVGEGREFAKALREASTSPVVYAEIPHAQHAFDFFGSPHGHYTADAVEKFLNWVLAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPI6</accession>
    <name>A0A132PPI6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11280</name>
        <name evidence="3" type="ORF">AWC31_30615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848146.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30615"/>
    <dbReference type="EnsemblBacteria" id="KWX23952">
        <property type="protein sequence ID" value="KWX23952"/>
        <property type="gene ID" value="AFM11_11280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12348">
        <property type="protein sequence ID" value="ORX12348"/>
        <property type="gene ID" value="AWC31_30615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6333"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX12348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="273" mass="31147" checksum="DE624BEC2457C56A" modified="2016-06-08" version="1">MSAPTADRRATGVFSTTRAQIPQRTLRTDRWWQAPLLTNLGLAAFVVYATVRAFWGSAYWVEDYHYLTPFYSPCVSTACAPGSSHFGQWVGELPWFIPMAFISLPFLLAFRLTCYYYRKAYYRSVWQSPTACAVAEPHAKYTGETRFPLILQNAHRYFFYAAVLVSLVNTYDAIVAFHSPSGFGFGLGNVILVVNVILLWVYTVSCHSCRHVTGGRLKHFSKHPVRYWMWTQVSKLNTRHMLFAWITLGTLVLTDFYIMLVASGTISDLRFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPJ7</accession>
    <name>A0A132PPJ7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_12285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848692.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09695"/>
    <dbReference type="EnsemblBacteria" id="KWX24127">
        <property type="protein sequence ID" value="KWX24127"/>
        <property type="gene ID" value="AFM11_12285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6536"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="146"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="9">
        <location>
            <begin position="223"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="338" mass="37498" checksum="1DFFEF9E81FCD531" modified="2016-06-08" version="1">MSVVLRKLTNVTVLAHRLDDDSPADAFLADAQRYRRELLAHCYRMTGSLHDAEDLVQETYLRAWKSYKGFQGKSSVRTWLYRIATNTCLTSLEGRQRRPLPSGLGTPSSAGADEIAEHHEVPWLEPLPDDSTDPSNIVGSRESVRLAFVAALQHLSPRQRAVLVMREVLQWKAAEVGDAIGASTAAVNSLLQRARAQLDAVGPTEDDKIEPPDSAEAQDLLSRYISAFEAYDVDRLVELFTAEAIWEMPPFDSWYRGPQAIGDLTRHKCPAEKAGDMRFIPTTANGQPAAALYMLNRETGTHEAFQIHVLDITPDGISHVVAFMEQSLFEKFGLPASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPL3</accession>
    <name>A0A132PPL3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polar amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_09810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847299.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05415"/>
    <dbReference type="EnsemblBacteria" id="KWX24278">
        <property type="protein sequence ID" value="KWX24278"/>
        <property type="gene ID" value="AFM11_09810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6000"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="23"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="262" mass="28705" checksum="BEC98411ACB669A8" modified="2016-06-08" version="1">MNFDWDFFWKSLLTPSEPFLDGLVLTIVISVVAMVLATVLGLVIALMRRSHIAALRWFAGFYIWVIRGTPLLVQLVVIYTGLAAVGLYEFHDVSFVGISVKAAVQAAIVGLMIHESAYIAEIVRAGLDSVPKGQFEAAASLGMRPSKVMRWIIVPQSLRVMVPPLGNTFNGLMKTTSVLSVIGVSELFLVTQSISSATFFTFEIFLVAAIYYLALTTIWTFIQAAIENRLARQLGIDQPVRITQRLLGGRKGSNAATLQPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPP0</accession>
    <name>A0A132PPP0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848318.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30465"/>
    <dbReference type="EnsemblBacteria" id="KWX24002">
        <property type="protein sequence ID" value="KWX24002"/>
        <property type="gene ID" value="AFM11_11585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6394"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009793">
        <property type="entry name" value="DUF1361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07099">
        <property type="entry name" value="DUF1361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453469" evidence="2">
        <location>
            <begin position="25"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="224" mass="24817" checksum="705B247E779EEBEE" modified="2016-06-08" version="1">MTNARRVVLILSLLATTGLTLVLGVTDPAAPLSYPTRFLVWNLFLAWIPMVFAVGFAVVRRRLWLVPLGLIWLAFLPNAPYLVTDLVHLGEGYELWRHVLQYGFAAWTGILLGVVSLLLVHQRVDRDLGRVWGWLTVVVSVGLCAIGVVIGRFQRWNSWDLVTRPESVVAATLEWVRSPFAYVQSTGVAVAVAAFFGLAYLTVWSLSGPVDVAHQRTSVLGEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPY6</accession>
    <name>A0A132PPY6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847689.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19000"/>
    <dbReference type="EnsemblBacteria" id="KWX24399">
        <property type="protein sequence ID" value="KWX24399"/>
        <property type="gene ID" value="AFM11_10565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6153"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="308"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="391" mass="41054" checksum="7489BF1658970FFB" modified="2016-06-08" version="1">MPYITSIGTYLPCWGTQHRRSAGDDEDAITLAVEAGRAALSPGGAVERVVLVSRDLPLVESSNAAVLLAGLGLDPELEVNERLGGVPATLDAVSSARPRTLIIGVDLDPAGAAAILTAEDGLRVRTAARVARSLPVRTRNVGGVVHDYGDPRLLHERGLLTSLAAAWLDTPVQLAGVDHDKAVELCQGTPRQLLTTGASSGLFALASLAESDTIGPLVAVEQASLSGVTVAGGTAQVIRMEREVRQMPEGTVTPGADLQISLAAYERAFEAKVRWEAGQYAGSPGDLDFPPRFRVGADGTLNTEYELVPLPRTGTVYTEVTVQIPVPGLRTPYSLVIVELDGVGVRALVKVTGAEPGSVDIGDRGRMVLRRIAVRSGVPDYGYAFEPEMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ09</accession>
    <name>A0A132PQ09_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clpX</name>
        <name evidence="9" type="ORF">AFM11_09870</name>
        <name evidence="10" type="ORF">AWC31_05355</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847333.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05355"/>
    <dbReference type="EnsemblBacteria" id="KWX24287">
        <property type="protein sequence ID" value="KWX24287"/>
        <property type="gene ID" value="AFM11_09870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09661">
        <property type="protein sequence ID" value="ORX09661"/>
        <property type="gene ID" value="AWC31_05355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6012"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX09661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="426" mass="46662" checksum="D14B3E37E1859037" modified="2016-06-08" version="1">MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELADADDVKLDELPKPAEIREFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGEKSRDSRSEPVELTKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVAGAFAGLEKIVSDRVGKRGLGFGAEVRSKAEIDTQDHFAEVMPEDLIKFGLIPEFIGRLPVVASVTNLDKDSLVKILSEPKNALVKQYVRLFEMDGVELEFTGDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTKETVQDNVLPTIVPRKPSRTERRDKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ65</accession>
    <name>A0A132PQ65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inosose dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847917.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05540"/>
    <dbReference type="EnsemblBacteria" id="KWX24478">
        <property type="protein sequence ID" value="KWX24478"/>
        <property type="gene ID" value="AFM11_09685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5975"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="97"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="29886" checksum="C3F4D430598C8A1B" modified="2016-06-08" version="1">MRIAGAPISWGVCEVPGWGYQLHRDRVLTEMRGAGLTATELGPDGFLPADPVELTEVLDAQSLSCVGGFVPVVLHDANHDPARDLEGPLASLRAADAGVVVLAAATGADGYDSRPELDAGQWATLLANLDRLSRIAAEAGLLAVLHPHVGTMVETRSDVDRVLAGSSIPLCLDTGHLLIGGTDPLELAKAVPHRIKHTHLKDVDAALAARVQAGELTYTDAVGAGMYTPLGTGDVDIAGIVSVLRDNGFDGWFVLEQDTILQAEPTDEGPVRDVVASVAYLKSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQC0</accession>
    <name>A0A132PQC0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845990.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22025"/>
    <dbReference type="EnsemblBacteria" id="KWX24529">
        <property type="protein sequence ID" value="KWX24529"/>
        <property type="gene ID" value="AFM11_07525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5353"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="154"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="31145" checksum="31BCEDB68FBA913E" modified="2016-06-08" version="1">MNLDLSDDAKEFGRQALRAFEAAGGDALLQQAEAKPEAREALVTPVLDGLGAHELDPRTDPDSLEAAAALCRSAGYWALPYPVAERLAGTLVIAEDAPRAAVAGLDTSWTAATLDGRCFRITGTSGAGPAFTTALELAAVDGDADVALGLVLPCWTLLGMLDRAIDLTVAHVSLRKQFGQTLSSFQGVQFQLTEAEVERSGVDMLAKYALWSVGTPDAVNDALALRMAAVEASEVVFRVCHQLHGAVGFCDETTLSWLSRYSQPLRRLPFGLSQTRDALTARLGRRGLTGLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQC2</accession>
    <name>A0A132PQC2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_10410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847955.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18845"/>
    <dbReference type="EnsemblBacteria" id="KWX24495">
        <property type="protein sequence ID" value="KWX24495"/>
        <property type="gene ID" value="AFM11_10410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6121"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="6"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="422" mass="44496" checksum="5399C81AEC49291D" modified="2016-06-08" version="1">MRPWIVWTTGLLAYIVAVLDRTTLGVSGLQAADRFAANPSVLSTFVVLQVVVYACAQVPAGVLLDRFGSRVLIVSGAALMAAGQLVLALSESLPAALAARAIVGLGDAVTFISVLRLVPHWFKPAQVPLLTQLTGICGQLGQVLSAVPFLALLTAAGWTPAYLSVGAFGLLAMALAFALVRNTPHGSVVAAETTTVRDTLASVRTVWLRPGTRLGFFTHMGTQFSVTVFALMWGVPYLTVAQGLSTTAAGTLLTISVVTAISAGIVIGIFTGRHPHRRSRLVLAIIASNALAWTVVLALPGPAPLWLLLVLIVVISVGGPGSMVGFDFARTFNPSATLGTAQGMVNMGGFLAALLVMQAMGVILSHAGSYSFESFRVAWTVQYAVWVLATIGILITRMKARRLLKAEQERMLLEGFEAHPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQG9</accession>
    <name>A0A132PQG9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histidinol dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFM11_07790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 15">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846125.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24576">
        <property type="protein sequence ID" value="KWX24576"/>
        <property type="gene ID" value="AFM11_07790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5409"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KWX24576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="451" mass="47813" checksum="9C8C5E8FA75F177B" modified="2016-06-08" version="1">MQITTEEARTLGPFTWLKKPAVDGPPAQRDPKVVERVSQMLLDIERRGLDAVRAYAQELDGWSGPLEISADELRKSGDALPADVREALELGYERTNRFAVAQRARLTDFEIELAPGVSGGVQYVPVNRVGAYLPAGRFPLLASAFMTVGVAKAAGVPTVLACTPPTGEHGAHPAVLYGAYLSRADSVFAVGGVQALGAMAFGLIGDGPVDMLVGAGNAFVTEAKRQLFGRVGIDLLAGPSEVAVLADETADPEWVAADLLGQAEHGPNSPAALITTSETLGRKVIEAIDRQLETLATREVAGPAWRDFGSVVVACDAEQAAAIADVLGPEHLEVQTADDDYFLKRLRNYGSLFLGRWSTVAYSDKGIAGTNHVLPTGKTARYNAGLSVSRFVKPLTYQRAAREATAELAPAVERISAFEGLAAHEATATIRIEEIGRNSAVFDGTPAASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQV7</accession>
    <name>A0A132PQV7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_07850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846154.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24460"/>
    <dbReference type="EnsemblBacteria" id="KWX24587">
        <property type="protein sequence ID" value="KWX24587"/>
        <property type="gene ID" value="AFM11_07850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5421"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="192" mass="20428" checksum="83D4669D9AB13AFF" modified="2016-06-08" version="1">MNERLDSPVQRVSLAELAWTFNHIALASFGGGLSAWSREVLVVEKRWLGEAEFLSAMTMCRILPGANQVNMAVFAGTKMRGLPGAVAAVVGLCLVPMVIVLVMAFAYFRFKEVPAVKGVLHGASAAAVALTVAMVVKTGRQCLTGLVPVLLFAGAFVLNGLLRWPLLGTLAILAPLSLIWAWPRKSAERAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQX5</accession>
    <name>A0A132PQX5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846599.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13610"/>
    <dbReference type="EnsemblBacteria" id="KWX24741">
        <property type="protein sequence ID" value="KWX24741"/>
        <property type="gene ID" value="AFM11_08760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5600"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007362">
        <property type="entry name" value="DUF429"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04250">
        <property type="entry name" value="DUF429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="1">
        <location>
            <begin position="292"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="565" mass="62718" checksum="79F7E9D8FD1EBA5B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR55</accession>
    <name>A0A132PR55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846819.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13210"/>
    <dbReference type="EnsemblBacteria" id="KWX24809">
        <property type="protein sequence ID" value="KWX24809"/>
        <property type="gene ID" value="AFM11_09160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5681"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="156" mass="16902" checksum="84F03100B41874E7" modified="2016-06-08" version="1">MTKRDERAPAPDVDSLARSMLQLLGHDEDEEHVTSGGRSSGSWSKAPDFASDPQRAAAVREATQRDRERYLTSGLVSVDCRFCHVAVQVKKLGPQHTSVQWNSEATQRCAVFNEIRESGGDPARARSCPRLADSIKHAIAEGCLEEVSSAPSPGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR97</accession>
    <name>A0A132PR97_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13385"/>
    <dbReference type="EnsemblBacteria" id="KWX24861">
        <property type="protein sequence ID" value="KWX24861"/>
        <property type="gene ID" value="AFM11_08985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5647"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="151"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="373" mass="39786" checksum="6FC9CC64C49D84CF" modified="2016-06-08" version="1">MLLAGCQFGGLNSLNMPGTAGHGPGSYTVTVQLPDVATLPQNSPVMVDDVTVGSVSGLDAVQRPDGTFYAAVELSLDGNVKLPANATARVAQTSLLGSQHVELAAPADEPGEGELREGSNIALAESGRYPTTEEVLSSLGMVVNKGNLGALQDITDEAYAAVAGRAGSFTDLIPRLAELTSSLDRQTNDIIAAADGLNRFASILARSKDNLGRTLDTLPAALKVLNDNRTNIVEAFTALRSFAEVGSRILSQTKDDFAADLKDLYPVIKAFNDNVDDFIKDLEFLPTFPFHYKYLRQAVRGDYLNVFVTFDLTLRRFGESIFTTSGFDPNMKHMSEVINPPDFLTGAMANLSGQAADPFKIPPGTATQHEGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRC5</accession>
    <name>A0A132PRC5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ruvA</name>
        <name evidence="10" type="ORF">AFM11_05370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844970.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12745"/>
    <dbReference type="EnsemblBacteria" id="KWX24880">
        <property type="protein sequence ID" value="KWX24880"/>
        <property type="gene ID" value="AFM11_05370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4263"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="20073" checksum="F4A32B5000B046F0" modified="2016-06-08" version="1">MIASVRGEVIDIALDHAVIEAAGVGYKVMATPSTLATLRRGTESRLITAMIVREDSMTLYGFADGDARDLFLTLLGVSGVGPKIALATLAVHDPQALRQALADGDVTALTRVPGIGKRGAERMVLELRDKIGPVTPGPGLAAAGHAVRGPVIEALVGLGFAAKQAEEATDKVLANDPEATTSAALRAALSMLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRD0</accession>
    <name>A0A132PRD0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845020.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24908">
        <property type="protein sequence ID" value="KWX24908"/>
        <property type="gene ID" value="AFM11_05545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4299"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="376" mass="38593" checksum="943107AF8EB1F048" modified="2016-06-08" version="1">MATAPSTRPQSAALPLWPLVAAICLLAALLWTGSLHVVAPMLDMIAAAASEPNFYGSALAGAGLLAGGVVAHRLQVKRRPCQGFAQACGSGLWVATLASSLLGVAISNLVWGWTLSEGTWQPLFVPFVSVSPTVVLMFGAEAKTVLTGGVLGGLITPPLSVLGADLCSRLTLPPVVGITAGMAVAAVIAFTLCRHLPWLPCPLHLQRAPAVADVGTGAQKHGPGWLLRRCLADFSEAQFFGSEWASFGLIAGVVLAYLLNPAMVAYGSGLLPQILAAQAITAIIAVTLWRGQWARKPFYPTFVPVVSVAPACVLAYGGTAVSIVAGAVLGALLSPPLAAAISSRLPTDFHPFIGNVAAMAVATSVIIPPLQLLPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRD1</accession>
    <name>A0A132PRD1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846651.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13515"/>
    <dbReference type="EnsemblBacteria" id="KWX24757">
        <property type="protein sequence ID" value="KWX24757"/>
        <property type="gene ID" value="AFM11_08855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5619"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="191" mass="21657" checksum="6B9F9F47BC45AB12" modified="2016-06-08" version="1">MASFERAQLEDWVERWLQVNRDAEKAGDWKPLADFYTDDATYGWNIGPKEDVMCVGIDEIRDIALGLEMEGLGNWTYPYQKVIIDDKQGEVVGFWKQVVGGADKAAGDTDADALEVYGIGGSWFRLADVDGEPKIEWQRDFFDFGHVQKLYLKLMENGKLSEGMQKRIERALAGEKLPGYYPLGEAPVPIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRH2</accession>
    <name>A0A132PRH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846319.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00095"/>
    <dbReference type="EnsemblBacteria" id="KWX24642">
        <property type="protein sequence ID" value="KWX24642"/>
        <property type="gene ID" value="AFM11_08170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5485"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="141" mass="15867" checksum="F83B55D0D61FE21E" modified="2016-06-08" version="1">MALSKEEREQFLAEPHIAALSVYAGDKRGPLTVPIWYQYSPGGEPWVLTGVGSRKHRLIEAAGHFSLMVERLEPTVRYVAVDGAVSRIEPSTDEQLVEMTKRYLAPEKVEGYLEFARREHGESVTVYLKPEHWLSADLGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRI5</accession>
    <name>A0A132PRI5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846813.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24807">
        <property type="protein sequence ID" value="KWX24807"/>
        <property type="gene ID" value="AFM11_09150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5679"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453265" evidence="2">
        <location>
            <begin position="28"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="210" mass="21234" checksum="603815C767885463" modified="2016-06-08" version="1">MSFTSAGRLKSLLTTALAAVLVVSAGACDATQTPPASAPAPGLPAAAPTTTTSPKPQASDYSHLLLQAEDVSIPPNTFTARSTTVNPDGQDGASALFVNADDTRAIADTILIYPDVATASATLRQASAAVSTIVTGGPPQPVPVGTGGTVISGTAPDGSKAVTLLMFTQGRALVRLEFDSTPQDPVSPQTVASVGRMQQIALRIGLPERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRI8</accession>
    <name>A0A132PRI8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845130.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11725"/>
    <dbReference type="EnsemblBacteria" id="KWX24961">
        <property type="protein sequence ID" value="KWX24961"/>
        <property type="gene ID" value="AFM11_05865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4364"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="804"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="870" mass="91770" checksum="97401B8462ABD654" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRM0</accession>
    <name>A0A132PRM0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845178.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29625"/>
    <dbReference type="EnsemblBacteria" id="KWX24991">
        <property type="protein sequence ID" value="KWX24991"/>
        <property type="gene ID" value="AFM11_06035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4399"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="98"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="199" mass="21244" checksum="BF06D914B8FF4616" modified="2016-06-08" version="1">MFTGIVEELGVLVDKEDLADAARLAIRGPIVTADARHGDSIAVNGVCLTVVDIRPDGIFTADVMAETLNRSSLQKLEVGGRVNLERAAAVNSRLGGHIVQGHVDGTGHVISRTPSEHWEVVRIGLPEALSRYVVEKGSITVDGVSLTVSGLGDDWFEVSLIPTTRELTTVGHADVGAQVNLEVDVIAKYVERLMSRTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRN2</accession>
    <name>A0A132PRN2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845158.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24980">
        <property type="protein sequence ID" value="KWX24980"/>
        <property type="gene ID" value="AFM11_05965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4385"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="456" mass="51683" checksum="46E7769984599392" modified="2016-06-08" version="1">MAAPAQRLNTWTMTRDAITVGFDATGGFMSHVSGHDITRFRCGGRRFVSVTHPDYIDHVLHRARLKYIKSNEYEAIRAAAGINLLTDEGDSWAAHRAALNPTFARRHLNVIIDLMIDPIEQVTTDVVPGVEFDMHTTMVETTLRVVANALFSQDFGPLVRSMKDLTTRGLRRTERLARLGLWGLMPRPVYDALTWCTFSGVPLPPPVREGQKIALALDDAVARILDERIARPTDSPDLLNVLFSADNGTWPRRRIRDEALTFMLAGHETTANGMSWFWYLLSLNPDARDRMLAEIDDVLADRRPSAADLTGLPWTTACIQESQRYYSAVWMMAREAIEDDLIDGHHIRPGTTVLIPIHHIHHDERWWPDPERFDPTRFLGTATKDRPRSAYLPFGGGRRICIGQSFALMEMVLMAAIMSRRYTFDVCPDHPVELEATLTLRPKHGLHVIAHQREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRN3</accession>
    <name>A0A132PRN3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol acetyltransferase</fullName>
            <shortName evidence="2">MSH acetyltransferase</shortName>
            <ecNumber evidence="2">2.3.1.189</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mycothiol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mshD</name>
        <name evidence="4" type="ORF">AFM11_08520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol</text>
            <dbReference type="Rhea" id="RHEA:26172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16768"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="EC" id="2.3.1.189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. MshD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846497.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13845"/>
    <dbReference type="EnsemblBacteria" id="KWX24702">
        <property type="protein sequence ID" value="KWX24702"/>
        <property type="gene ID" value="AFM11_08520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5552"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035447">
        <property type="term" value="F:mycothiol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01698">
        <property type="entry name" value="MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017813">
        <property type="entry name" value="Mycothiol_AcTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021524">
        <property type="entry name" value="MSH_acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03448">
        <property type="entry name" value="mycothiol_MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="147"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 1" evidence="2">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 1" evidence="2">
        <location>
            <begin position="85"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="272"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="296" mass="31845" checksum="DE9E7D95A345E632" modified="2016-06-08" version="1">MTAADWRTGLSGADQAQVREVIAAAAAHDGVAPVGDQVLRELGHDRTRHLLATDDDRVVGYLNLAPAGADDPAMAELVVHPQARRRGIGSAMARTALAEGGAGARVWAHGNLEPARALASSLGLSIVRELLQMRRPLVDLPPLRELPAVRIATYSGPDDDAEILRVNNAAFSWHPEQGGWTEREIDERRNEPWFDPEGLFEAFDEQTGRLLGFHWTKVHDADVGEVYVVGVDPEAQGRGLGAALTLVGLHHLADRLTASSQPTVMLYVEADNSAAVNTYRKLGFEVFGVDAAYAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRR2</accession>
    <name>A0A132PRR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845114.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11690"/>
    <dbReference type="EnsemblBacteria" id="KWX24954">
        <property type="protein sequence ID" value="KWX24954"/>
        <property type="gene ID" value="AFM11_05830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4357"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453530" evidence="2">
        <location>
            <begin position="19"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="440" mass="45656" checksum="EDAE9E09415FBD90" modified="2016-06-08" version="1">MPALRTSVICLTVVVAAAACATPREEEPAVTIERLVALSDGDHLASTYADGILAPVSAGHRDLLSTVSVRDGVVDTAHVEVSNSVTAAPEVLALSPDGTTAFVAERLKPRNVGDTKAQQLAPGDRLFAVNISNRQAPAIGDVATIAPSPEALAVHPDGSHIAVVSNTADSSLLQFISWTPDGFGAVEQFDLAALGVPGEAGKPRGGLTATNVHWHPTGRALAVNIDSQNRVAFFTVDTSVPGRPGVHAWGEPVATGVDPFVGRFTPDGRHYLTSDWGRDLSTTDLNKRLPTGRSTLSVIRVGDPGADQPRKVGTAESDKSAEGLAISPDGRWVATVNMRGTAVPAGSPLHDDHATVSLLRLDGDTGELSKVGDYHLDGVLPEGGTFDATGRYFLATVYEGRPGGNGSGVQVYRVGSADDPGLTAVQRIPLPHGVHHVVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRW1</accession>
    <name>A0A132PRW1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_06290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845257.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29385"/>
    <dbReference type="EnsemblBacteria" id="KWX25035">
        <property type="protein sequence ID" value="KWX25035"/>
        <property type="gene ID" value="AFM11_06290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4452"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="63"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="287" mass="31593" checksum="B2B941BFCED774A1" modified="2016-06-08" version="1">MKFKYGMLMPLLALFGVAVGFPLCYAAYLSVTDYKLTDREPPGFVGAANFTNALSNTAFWEAFGTTAIYVLIAVSVELVLGFSLALALHQQRWAKDLSRAIVLAPMFITPIAVGLIFRFLLNDQIGAIPALLHTIGADYDFFGAGRALLTLAFIDVWQWTPFMVLLILAGLESMPKQPLEAARVDGAGPIYRLRRVMIPMLAPVLTVAVLLRGLDALRVFEYVYATTRGGPGTETQTLQYYMYLEGIQFFRLAQASAMAFVVLVLVLAVIVVAFRTMERSREGSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSK5</accession>
    <name>A0A132PSK5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anti-sigma-K factor RskA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sigma-K anti-sigma factor RskA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rskA</name>
        <name evidence="2" type="ORF">AFM11_03165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The cytosolic domain interacts with sigma factor SigK.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anti-sigma-K factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843868.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21930"/>
    <dbReference type="EnsemblBacteria" id="KWX25303">
        <property type="protein sequence ID" value="KWX25303"/>
        <property type="gene ID" value="AFM11_03165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2507"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="237" mass="24518" checksum="2AAFEAE3FCCB5178" modified="2016-06-08" version="1">MTSPGDPELLTLATPYALHAVPESELADIERRVAAAPPEVAEQFAAEVRAVRETMARVAASTAVEPPTDLRDRVLAAVAPGNMRELRPSRPRWRTALLAAAAAVVIALASIGVGIVMRPSATPSTAEQVFAAPDVRTVSGPIPTGGTATVVFSRDRNAGVLVMNGVTPPETGTVYQMWLMRDTGPESAGTMDSAAVAPSTTAVLPDLGDASALAFTVEPGTGSSTPTTPIFARLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT28</accession>
    <name>A0A132PT28_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptidyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844496.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20705"/>
    <dbReference type="EnsemblBacteria" id="KWX25498">
        <property type="protein sequence ID" value="KWX25498"/>
        <property type="gene ID" value="AFM11_04440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2764"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="168"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="412" mass="44611" checksum="DFC03174201FB71D" modified="2016-06-08" version="1">MKFLFDDESFSFETLRAAGYANAGGADLGEILVTARAIPEGDEAAWHREWKATAQRVEALGRQSLAAGRAVSAREALLRASNYYRTAEFYLRENPAHDPEAKELFARSRGTFLAAMPLFDFGFERIAIPYQDTALPGYLYLADDSGRPRPTVIFNGGYDSTLEESYVALAAGALARGYNVLAFDGPGQGAALREQGLTFRPDWEAVLTPVVDFALTRPEVAPDAIALFGYSLGGYLAARAAAFETRLAAVILNDGVYDFFAALTNMMPPFLVNWIDQGNDEAADAVIGLLMAVNTQTRWAVRNGLWALGIDTIPDLARAFKAYTIADVADRITTPTLVLDAENDQFFKGEPARAATAMVNAKTTLVTLYEADGAGEHCHMGAASRANQVMFDWLDAELHRAVAPGEQIAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT38</accession>
    <name>A0A132PT38_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_04305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844460.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20850"/>
    <dbReference type="EnsemblBacteria" id="KWX25480">
        <property type="protein sequence ID" value="KWX25480"/>
        <property type="gene ID" value="AFM11_04305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2739"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="626"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="844" mass="89710" checksum="F87750E42A47558C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT81</accession>
    <name>A0A132PT81_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03845</name>
        <name evidence="3" type="ORF">AWC31_21320</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844227.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21320"/>
    <dbReference type="EnsemblBacteria" id="KWX25407">
        <property type="protein sequence ID" value="KWX25407"/>
        <property type="gene ID" value="AFM11_03845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16570">
        <property type="protein sequence ID" value="ORX16570"/>
        <property type="gene ID" value="AWC31_21320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2645"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="11"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="164" mass="16527" checksum="A99A34FE9FE30E95" modified="2016-06-08" version="1">MEQPGELVGRALVVVVDDRTAHGEEDHSGPLVTELLGEAGFVVDGVVVVAADEVEIRNALNTAVIGGVDLVVSVGGTGVTPRDVTPEATRDILDRELLGISEALRASGLSAGIVDAGVSRGLAGISGSTLVVNIAGSRAAVRDGMATLSPLAVQIIGQLSSLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTK4</accession>
    <name>A0A132PTK4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844566.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20535"/>
    <dbReference type="EnsemblBacteria" id="KWX25527">
        <property type="protein sequence ID" value="KWX25527"/>
        <property type="gene ID" value="AFM11_04610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2801"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="364" mass="37481" checksum="71C44706A6E35509" modified="2016-06-08" version="1">MAKNFLRALSRVVRQETAAEEPSAGSVTFDGALDDVDVAGLVEVGRGPIGDIAVDAERDTIVVTNSATDCLTVINPYTLAVVGSVRLGGEPFAVTAADDRAYVSVTSAGHDAIVVVDTITGAVLAEYPLALTVTALAMSPDGKRVFAGRSGDDRIDIAVIDTTAQRVGTIDIATGVGVSLDALHVDSTGKRLYAATSDARGSRVVTVNAETAQIESTVWIGAPIRDLALGADGIAYVLTSDRQYRGVVHLVDLAAATVVGAVQIGGAPTQLVLSPDATRAYVVDYDRIIVLCTLTNEVLGSVVLHAQPAAVTVRDDGARVYVADYTGHVNAFDVAAPLPALYSQLVATEPAPLPELPALAPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUM0</accession>
    <name>A0A132PUM0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842934.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34595"/>
    <dbReference type="EnsemblBacteria" id="KWX26013">
        <property type="protein sequence ID" value="KWX26013"/>
        <property type="gene ID" value="AFM11_01815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.373"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021385">
        <property type="entry name" value="DUF3017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11222">
        <property type="entry name" value="DUF3017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="97" mass="10232" checksum="E9D98CD51D048A9E" modified="2016-06-08" version="1">MTLKEFARKVFAGQWPILVVGLIFIAAFALVVAGYWRRGALVIGIGVGVAAALRLALTDDRAGLLVVRSKGIDFVTTATVSAAVLYIAWTIDPLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUN1</accession>
    <name>A0A132PUN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842968.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34670"/>
    <dbReference type="EnsemblBacteria" id="KWX26023">
        <property type="protein sequence ID" value="KWX26023"/>
        <property type="gene ID" value="AFM11_01880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.386"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="131" mass="14793" checksum="248E96806D2E9718" modified="2016-06-08" version="1">MLAPLLRELIDAEMPVLEAHDVTMWGYVVLCALDRSSMRTQAALAEAIGADKTRIIRTLDELQQRGLIDRQPDPDDRRVRLLAITAAGRDLKDAVQAEIQRGEDRWLGELSTDDRKAFLRVLAQLTREENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUR6</accession>
    <name>A0A132PUR6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">23S rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_01820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842937.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34600"/>
    <dbReference type="EnsemblBacteria" id="KWX26014">
        <property type="protein sequence ID" value="KWX26014"/>
        <property type="gene ID" value="AFM11_01820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.374"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="6">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX26014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="246" mass="27265" checksum="A7432AC8FA980350" modified="2016-06-08" version="1">MSSPSHGRHEFGQNFLCDHRVVADIVEIISRTTGPIVEVGAGDGALTVPLQRLGRPLTAIEIDSRRAERLAGHTSAKVVATDFLRFRLPRTPHVIVGNLPFHLTTAMLRRLLHGPGWTDAVLLVQWEVARRRAGVGGATMMTAQWWPWFEFGLARKVSANAFRPRPTVDAGLLIITRRAHPMIDAADRRRYQALVHQVFTGRGRGIAQIIGRRVPRHWLRDNGINPAALPKDLTATQWAALFAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUU9</accession>
    <name>A0A132PUU9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843279.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26121">
        <property type="protein sequence ID" value="KWX26121"/>
        <property type="gene ID" value="AFM11_02465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.505"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="125" mass="13294" checksum="A48108B54E5B570E" modified="2016-06-08" version="1">MYHDARDLRSGDVDVWQAVRFGLVAAAAGLGFLLMAVTWVSTCAGATADMAACGAPQRTALALGAPLILFVAGLRAFTRAYQAWKRRETWWAWHGAGWLLTLLTLLVLVTSLPAFGGTGTTGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV71</accession>
    <name>A0A132PV71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843450.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26174">
        <property type="protein sequence ID" value="KWX26174"/>
        <property type="gene ID" value="AFM11_02800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.576"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="106" mass="11529" checksum="709EC5410661B049" modified="2016-06-08" version="1">MRAHRQGEGTGWVRRAPVPTPSGSSVPPGTLINNRWSATELTDLPEHRDAGHAVAARRTGRLGQPAVPAPTGSRRVISGNDAVRQEDSLSVRRAVQWAHPGKRSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVG5</accession>
    <name>A0A132PVG5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842965.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34665"/>
    <dbReference type="EnsemblBacteria" id="KWX26022">
        <property type="protein sequence ID" value="KWX26022"/>
        <property type="gene ID" value="AFM11_01875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.385"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="205" mass="21843" checksum="708924B8803E1245" modified="2016-06-08" version="1">MHTIDADIRPHHRIAVLRTIDLVDTVAASDLDRPTPCADWNLADLLAHMTVQHRGFAAAARGNGSDEAVWRPETVAGAVRADPKGAYAAAAHDVLDAFATDGVTEATFALPEFGPNATFPGALAIGFHFVDYVVHGWDVAAALGVPYDLPDDVIAAVLPLVEAIPDGDFRETAGAPFGRAVNAPATTNFERILAHLGRRPDWRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB39</accession>
    <name>A0A132PB39_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000043">
        <property type="protein sequence ID" value="KWX19528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040740.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19528">
        <property type="protein sequence ID" value="KWX19528"/>
        <property type="gene ID" value="AFM11_35345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5800"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="110" mass="12356" checksum="8DEB79F158C62258" modified="2016-06-08" version="1">MKLEWEGEEEDRLAAIRAAEERDRLEARVNGAPIVIANEFSEVQVSRVETRNGSRLMIKSPRSGQWVSLCPLELEALTWQAPATFSAMIGHPFGPLVTEDEQPPQNKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB88</accession>
    <name>A0A132PB88_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoadenosine phosphosulfate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19578">
        <property type="protein sequence ID" value="KWX19578"/>
        <property type="gene ID" value="AFM11_35175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5764"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="12"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="29940" checksum="11096EAF3F5600A5" modified="2016-06-08" version="1">MPNLADYDLLLLNSSAGKDSQAALDVVAGVAAAQEISDRLVVVHADLGDADWDGVPELAAEHAAHYGVRFEITARRRDGDIETILDRVEERGMWPDAARRWCTSDHKRGPIRKVMTRLVTELRDSGRVTDRPVRVLNILGYRAEESPARARRSPYAHNPASSNGRRIVDDWYPIHDWSVRQVWARIAAAGTRPHPAYGAGMSRLSCRLCVLSSRGDLVCSARLNPGLADRYAAVERKIGHRFRKDLSMADIIAEAQGDTAQLALLPIAHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBC4</accession>
    <name>A0A132PBC4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_27 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859605.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02020"/>
    <dbReference type="EnsemblBacteria" id="KWX19604">
        <property type="protein sequence ID" value="KWX19604"/>
        <property type="gene ID" value="AFM11_35000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5729"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038734">
        <property type="entry name" value="YhaN_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13514">
        <property type="entry name" value="AAA_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_27" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="877" mass="93809" checksum="C3D19EFA3684C2D6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBE1</accession>
    <name>A0A132PBE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859297.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17300"/>
    <dbReference type="EnsemblBacteria" id="KWX19651">
        <property type="protein sequence ID" value="KWX19651"/>
        <property type="gene ID" value="AFM11_34495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5244"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="32896" checksum="EC81C89390FF95DC" modified="2016-06-08" version="1">MDEWECAVVGGGAAGLSAALVLGRARRRTLVVDAGEPSNQSARAIGGLLGHDRRPPAELYTTGRRELAEYPSVQYVAGEVISGKTVDDRHVLELDSGETIAARRVLLATGMRYCPPELPGLDELWGKSVFQCPFCHGWEMRDKRLAALAAGDDAVHAVLMLRGWSDDVVLLTDGAPDLPDGERRRLAAAKVDIDERRIVELIGQDGELTAIAFADGSRLERDGLLVEAPLRQRSGLATQLGAACSAGPTAPDSLDVDALHRTTVHTVFAAGDPCTEQPYLAGAIAAGAEAAMIIVQSLLADEFSLPYPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBH5</accession>
    <name>A0A132PBH5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19668">
        <property type="protein sequence ID" value="KWX19668"/>
        <property type="gene ID" value="AFM11_34605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5267"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="64"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="197" mass="21023" checksum="E2D927F7803D234E" modified="2016-06-08" version="1">MAAVNEKLGGRLPLVDPAGLTPEQQDLAASVRATQLPWAAGAGFEITSPDGRLIGPFNAFLHHPEIASRFLAFSAAESRYTTLGERIREIVILAVGRVWAAEYELYAHSVLAANAGIDRAAIQALAHGEAPTSLHGDELVAAELAQQLSKNHRIDEALYRVAEAAFGRRGLFDIVALMGQYLTVSALLSLFEVPAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBI0</accession>
    <name>A0A132PBI0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859398.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19680">
        <property type="protein sequence ID" value="KWX19680"/>
        <property type="gene ID" value="AFM11_34680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5283"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="21657" checksum="7914C8EC0B4E6B1E" modified="2016-06-08" version="1">MAVSSAERKGDARDRLLARLLDAFGDGLPSPDMSLREVAARVETSHALLRYHFGSLPGVLAAMLTAQRSRDNEVLLKTAEEGAFDDLVVAIWHTYTRPEQLSRIRGFFHVVGLAAYNPGDFHEFIDSLDDLTTMLASLAEREGHETERALSMATVAVAAIRGLLLQEILNPSAHSEGTVALMLRMIGGPMRTKATERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBJ3</accession>
    <name>A0A132PBJ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease, DMT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859418.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19686">
        <property type="protein sequence ID" value="KWX19686"/>
        <property type="gene ID" value="AFM11_34475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5240"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="164"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="306" mass="31744" checksum="FB861783D1D22117" modified="2016-06-08" version="1">MRAPRRDSYDRAMVTDRPALTTALGALGVSASGLFVALSATSPGTASFFRCVFALPLLAPLAVAEWRRRGVPPARQQGWAAAAGVLFAADALLWTQAIYEVGVGITAVLVNTQVVIVPLLARFIDREPLSRHFVTLLPVVVVGTVLTGGILETGVIGTAPVAGTVHAALAAVCYSVFLFLLRRGGPDRPQVQSYVAIMASAAIGALAGGALWGGVTLMPGWGAMGWLVLTAITGQVLGWLLVALGSPLLRAEVSSALLLLTPIGALVLGAAFLGQVPSMWQMVGSLLILCSAYLITTRRPAVRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBP3</accession>
    <name>A0A132PBP3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_36055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000076">
        <property type="protein sequence ID" value="KWX19402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19402">
        <property type="protein sequence ID" value="KWX19402"/>
        <property type="gene ID" value="AFM11_36055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="119" mass="12839" checksum="19498BACCBA14FAB" modified="2016-06-08" version="1" fragment="single">MFESLFDIDPGASEQQLRALVEKYELLKPALAAAQARATALWDAKRRAREAADGVPAATRGKGLAAEVALARREAPKKGDQYLGLAKALVHEMPHTLAALEAGMLSEWRATLIVRESAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBS7</accession>
    <name>A0A132PBS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aconitate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_34095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859071.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02545"/>
    <dbReference type="EnsemblBacteria" id="KWX19785">
        <property type="protein sequence ID" value="KWX19785"/>
        <property type="gene ID" value="AFM11_34095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5156"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006250">
        <property type="entry name" value="Aconitase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01342">
        <property type="entry name" value="acon_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="6">
        <location>
            <begin position="529"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="648" mass="69399" checksum="EB24FFCD684B0E6B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBX5</accession>
    <name>A0A132PBX5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Methionine synthase</fullName>
            <ecNumber evidence="6 20">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 20">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">AFM11_33725</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 20 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 20 22">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="20">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6 20"/>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858851.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08030"/>
    <dbReference type="EnsemblBacteria" id="KWX19818">
        <property type="protein sequence ID" value="KWX19818"/>
        <property type="gene ID" value="AFM11_33725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5081"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 20 22" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="17 20 21" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 20 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 20 22" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 20 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="15 20 21" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="25">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="26">
        <location>
            <begin position="370"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="29">
        <location>
            <begin position="662"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="28">
        <location>
            <begin position="768"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="27">
        <location>
            <begin position="918"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="22">
        <location>
            <begin position="778"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="22">
        <location>
            <begin position="1213"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="710"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="781"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="826"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="830"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="882"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="969"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KWX19818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1252" mass="137203" checksum="48BFABD4B74DF371" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCF3</accession>
    <name>A0A132PCF3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19662">
        <property type="protein sequence ID" value="KWX19662"/>
        <property type="gene ID" value="AFM11_34565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5258"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="184" mass="20881" checksum="84A675F3DABED985" modified="2016-06-08" version="1">MLLHWYDEMSSDDFFGEISDDVRTAVNTMLNRRQINVLPYRTNAERSIMAGKFIEDLDRHMLFRVYIPAGRLYAEEASTLLGLFRDWLNQTGRDAIRQDGYTTPAGHVYEFFGEKSQQAWELSRQFSDFSDFLESCHSAPEAALDGLLSAGVEPVVADQMVAKYAKAGRRLQLDLRPNSGTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCF4</accession>
    <name>A0A132PCF4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858423.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32130"/>
    <dbReference type="EnsemblBacteria" id="KWX19984">
        <property type="protein sequence ID" value="KWX19984"/>
        <property type="gene ID" value="AFM11_32755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4880"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="243" mass="26755" checksum="9CA88F19017D1F08" modified="2016-06-08" version="1">MDLMPKADLSDADVAEALGRAVGVIDLILDVLSETDPLGLRRRTHDRDSADSLVDRPLNLLAGLLDCADVPGTKSWARKDRAGRIRWWVRRVGALDTVVVAFPGVFGVLADRLPLQDLFGFTNQAIVLCAVAREYGITDHQTQVRLLAAVLCGRELTDEAGAVPPPEPDADWSQMSLVKKLWQLVGIMNAIGDELGKRPHPRRLFRYFGMLPWIGAVADYFGEYGALVRAADAAQIWITNNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCG5</accession>
    <name>A0A132PCG5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858383.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32410"/>
    <dbReference type="EnsemblBacteria" id="KWX20018">
        <property type="protein sequence ID" value="KWX20018"/>
        <property type="gene ID" value="AFM11_32965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4923"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="30131" checksum="0562513013933BBD" modified="2016-06-08" version="1">MQKPGQTPGRPVADTGLLVAAIRAEETRRDDGLFSDPFAEKLAGESGRRLLADALAATGEKTTLQIIVRTRFWDEALLRATRTVDQVVILAAGMDARAYRLPWPDGTVVFELDQPAVIAAKNERLAEDRPRCRRVALGVDLTADWTASLYDNGFDADKPAVWLIEGLLQYLDEAAVHTLFDRVDAMSAAGSVLLYDVVGKTLLDAAMLAAVRESMAASGAPWLFGTDQPGELSGRLGWSAVVTDIAEPGNAWNRWFAPAVPLDVPGVPRGYFVEATKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCH5</accession>
    <name>A0A132PCH5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_33025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32470"/>
    <dbReference type="EnsemblBacteria" id="KWX20029">
        <property type="protein sequence ID" value="KWX20029"/>
        <property type="gene ID" value="AFM11_33025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4936"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043641">
        <property type="entry name" value="PPE-PPW_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18878">
        <property type="entry name" value="PPE-PPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PPE" evidence="4">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="PPE-PPW" evidence="5">
        <location>
            <begin position="467"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="530" mass="53494" checksum="C824B0002D765AA7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCM9</accession>
    <name>A0A132PCM9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858124.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19660"/>
    <dbReference type="EnsemblBacteria" id="KWX20083">
        <property type="protein sequence ID" value="KWX20083"/>
        <property type="gene ID" value="AFM11_32525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4833"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="1">
        <location>
            <begin position="71"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="246" mass="27802" checksum="B609045C9810029B" modified="2016-06-08" version="1">MRSAGEFQEVQRLIEAGMNDCAIARRTGIPRPTVQSWRRRPPNRLRLPSAASPCGVDHDSAVLPRREYAYLLGLYLGDGCVSQHPRAYRLRVTLDEKYPGIIDSCRAAIETLMPGQRASVERQPTACVVVSLYSKHWPCLLPQHGPGKKHTRPIRLEPWQKALVKEATEEFVRGLIHSDGCRVVADDRGVKSIRYHFSNRSDDIRGLYCEALDELGIPWTRPSKYDVAVYRKAATARLDEFIGPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCX5</accession>
    <name>A0A132PCX5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858103.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19590"/>
    <dbReference type="EnsemblBacteria" id="KWX20077">
        <property type="protein sequence ID" value="KWX20077"/>
        <property type="gene ID" value="AFM11_32465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4821"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="243" mass="26736" checksum="BE9A9370C65386FB" modified="2016-06-08" version="1">MDALERVVEQIMSSATRTSDGSIARLPTERQLAETLGISRGALREQLAALESLGLVTRTQGSGIHLAPTSPTPVRLYFDLSVRLGLITTDQLERGREMLEETVVRAAAVRATPADLAELEGYVEQMVDGSSSGDHQKADAADYNFHRCLYRIVDNPVLNLIADGLVDVLRELLTQRRVRAINSEEPDEHGHYRTDLIHQQIVGALRLRDPDLAAATMAAHFEQWRHITDEPADADEPGVRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDI5</accession>
    <name>A0A132PDI5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="4">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_31040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="4 6">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857259.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26750"/>
    <dbReference type="EnsemblBacteria" id="KWX20386">
        <property type="protein sequence ID" value="KWX20386"/>
        <property type="gene ID" value="AFM11_31040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4111"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026494">
        <property type="entry name" value="RNR_NrdF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04171">
        <property type="entry name" value="RNR_1b_NrdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="320" mass="36790" checksum="BCB795B931A18F6B" modified="2016-06-08" version="1">MKLIDRVSAINWNRLQDEKDAEVWDRLTGNFWLPEKVPVSNDIPSWGTLTEHEKQLTMRVFTGLTLLDTIQGTVGAVSLIPDALTPHEEAVYTNIAFMESVHARSYSNIFSTLCSTAEIDDAFRWSEENPNLQRKAEIVMQYYKGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKFQRGLALVDEAKRQELKDYTYELLFELYDNEVEYTQDLYDGVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAILSALSPNADENHDFFSGSGSSYVIGKAVNTEDEDWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDL8</accession>
    <name>A0A132PDL8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26485"/>
    <dbReference type="EnsemblBacteria" id="KWX20420">
        <property type="protein sequence ID" value="KWX20420"/>
        <property type="gene ID" value="AFM11_30765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4054"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="104" mass="11758" checksum="CE072AD93710B652" modified="2016-06-08" version="1">MAEGSADFVLVLEDLHDVGEAQTLTHQQAVQRIVDHCDMFEKIRFDLNLVVAGDDGEHVVIVYESPMTLKDGTEMTISSMEIFRVRDGRITEVWNCGYKQGVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDW8</accession>
    <name>A0A132PDW8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857019.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20523">
        <property type="protein sequence ID" value="KWX20523"/>
        <property type="gene ID" value="AFM11_30180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3932"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="122" mass="13805" checksum="BBCEBDBF88DC9790" modified="2016-06-08" version="1">MTATLPLTVRKAAETAARDHHLDLSPYLADLICFHYGRPDLMRHLTQAILFETASRTYDLTTDTYGRHQTIRLPVPVAELVEYEARDRGIQRSTLLADIVCLRMGFPGLIRAIDKEVMPLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE24</accession>
    <name>A0A132PE24_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856880.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20477">
        <property type="protein sequence ID" value="KWX20477"/>
        <property type="gene ID" value="AFM11_30355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3969"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="214" mass="23470" checksum="B3C4F78B5FD673B1" modified="2016-06-08" version="1">MSRRWSRNRLKFALAGPLFEAGNRFIPGHPHGRLAQLVAEVQPRRVLELCGGTGYAARLLAHKSPATRVDSLDISPEMLAVGRTRLHRAGISTVALHKGDVAALPFGDDTFDVVMSVFGWHELPTDIRHQAIDETLRVLRPGGQVIAIDLDPPPTARTVFDIYLRLTERPHARDVLGTGLADAFTAHGLTVTSHLPARSWAAPFQIVHAHERGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE59</accession>
    <name>A0A132PE59_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6285 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856656.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25320"/>
    <dbReference type="EnsemblBacteria" id="KWX20626">
        <property type="protein sequence ID" value="KWX20626"/>
        <property type="gene ID" value="AFM11_29980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3888"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046252">
        <property type="entry name" value="DUF6285"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19802">
        <property type="entry name" value="DUF6285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6285" evidence="1">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="112" mass="11766" checksum="94F4DB45B95FCD35" modified="2016-06-08" version="1">MSDLYGRPTAAELVAAVAEFLETEVRAETGGAVNFHARVAANALRMVERELLAGDPVDCDAALAELGFSGEAALASAIRSGELDDRAEDVTACLRVLVRQRLAAAHPGYDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEI9</accession>
    <name>A0A132PEI9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040659.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20704">
        <property type="protein sequence ID" value="KWX20704"/>
        <property type="gene ID" value="AFM11_29240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3733"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="119"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="342" mass="36740" checksum="D91254D60B1A709D" modified="2016-06-08" version="1">MSKQLKGTIWRLAVFLSVCALGTFALLAVFAEFRFDVGKTYFAQFSNVSNMRKGSLVRIAGVEVGKVRSISVNRDSTVRVEFSAENSVVLTEGSRAVIRYDNLFGDRYLALEEGAGGVKTLQPGDMIPLARTEPALDLDAVIGGFRPLFRALDPDQVNALTGQLIQAFQGEGSAIGSFLNQAAVLTNTLADRDQLFGQVITNLNVVLGSLGDQSDQLDKAVTSLSGLIDGLAGRKKDIANAVAHTNAAAGSVADLLTQVREPFQKVVHETDRAAGIVVADHDYFDNLLNTLPDKYKALARQGIYGDFFSFYLCDLILKLNGKGGQPVYVKVAGQSTGRCAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEU4</accession>
    <name>A0A132PEU4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856995.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20512">
        <property type="protein sequence ID" value="KWX20512"/>
        <property type="gene ID" value="AFM11_30580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4016"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="318" mass="32768" checksum="099140C7F3C34DD8" modified="2016-06-08" version="1">MNAAGRLSVYGVGLAVVFAAAFAVGGAVVPDDAGATWSQSATPGTHSEAADAATPGKDEQVSGLSLARSDFALGPVHAPTRAGVAGELSFQVRDAKGDQVSDFVASHERALHLMVVRSDGAGYQHVHPELDADTGTWSLPWRWDAAGTYRVFVDFVPADGADAHAVTLSRAVEVGGTFSPETVAGVSASDSVGGFDLRVTGDLVAGESSELAVAVSRDGRPVTNLQPYLGAFGHLVALRDGDLAYLHVHAEGSEPAAGETSGPTITFMTQAPTPGFYLLYLDFQVDGQVHTARFVLEAAPGDGSGEAQHGETHEHGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF67</accession>
    <name>A0A132PF67_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Arabinosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFM11_27590</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the emb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10120"/>
    <dbReference type="EnsemblBacteria" id="KWX20971">
        <property type="protein sequence ID" value="KWX20971"/>
        <property type="gene ID" value="AFM11_27590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3392"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052636">
        <property type="term" value="F:arabinosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071766">
        <property type="term" value="P:Actinobacterium-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032731">
        <property type="entry name" value="Arabino_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042486">
        <property type="entry name" value="Arabino_trans_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007680">
        <property type="entry name" value="Arabino_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040920">
        <property type="entry name" value="Arabino_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027451">
        <property type="entry name" value="EmbABC_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14896">
        <property type="entry name" value="Arabino_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17689">
        <property type="entry name" value="Arabino_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04602">
        <property type="entry name" value="Arabinose_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Arabino_trans_N" evidence="15">
        <location>
            <begin position="42"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Arabinose_trans" evidence="13">
        <location>
            <begin position="205"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Arabino_trans_C" evidence="14">
        <location>
            <begin position="695"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KWX20971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1068" mass="114431" checksum="5751FDECFFD4C752" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFD2</accession>
    <name>A0A132PFD2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_27170</name>
        <name evidence="7" type="ORF">AWC31_07020</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855323.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07020"/>
    <dbReference type="EnsemblBacteria" id="KWX21059">
        <property type="protein sequence ID" value="KWX21059"/>
        <property type="gene ID" value="AFM11_27170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09942">
        <property type="protein sequence ID" value="ORX09942"/>
        <property type="gene ID" value="AWC31_07020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3309"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX09942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="140" mass="14947" checksum="358A98340AE9892D" modified="2016-06-08" version="1">MTTNLETRLATYSPVVIGIFRVVFGFLFTIHGAAKLFAWPVDSGSGAIPVGTWPGWWAGLLELVLGLLILTGLFTRIAAFIASGEMAVAYFWQHQPNGLFPLENGGEPAVLYCFGFLLLAAIGGGAFALDTARGRRTARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFF3</accession>
    <name>A0A132PFF3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_29380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011331214.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20722">
        <property type="protein sequence ID" value="KWX20722"/>
        <property type="gene ID" value="AFM11_29380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3767"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="129"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="238"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="386" mass="42232" checksum="CCE14D121AB84219" modified="2016-06-08" version="1">MSELFPDYRSPWETDDQALLRKHAAEFFRKEATPNQDRWAAQHQVDREFWTKAGAAGLLCLDIAEEYGGGGGNFGHEAIVQQEIAYAHDTAFGFAVHSTIVAHYIAAYATEDQKKRWLSKCASGESVLAIAMTEPGTGSDLQAVRTTAVRDGGHYVINGSKTFISNASHCDLLVIVAKTDPSQGSKGISLLVAETENLPGFERGRVLDKIGQHGQDTRELSFTDMRVPAANLLGGVEGQGFYQLMGQLQRERLILGVGGVAVAEAAVAESIRYAKERHAFGKPILNFQNTKFVLAECKTDVLAGKTLMDHCIQRHLDGTLDAATASMAKLWGSDKQCEIVDRCLQVFGGYGYMMEYPIAQMYAASRVQKIYGGTNEIMKELIGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFY7</accession>
    <name>A0A132PFY7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855067.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22615"/>
    <dbReference type="EnsemblBacteria" id="KWX21245">
        <property type="protein sequence ID" value="KWX21245"/>
        <property type="gene ID" value="AFM11_26720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3215"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045699">
        <property type="entry name" value="GlfT2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040492">
        <property type="entry name" value="GlfT2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19320">
        <property type="entry name" value="GlfT2_domain3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17994">
        <property type="entry name" value="Glft2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glft2_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="GlfT2_domain3" evidence="2">
        <location>
            <begin position="453"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="653" mass="72109" checksum="AD6C4689E0F5ECD9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGN8</accession>
    <name>A0A132PGN8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="10" type="ORF">AFM11_25180</name>
        <name evidence="11" type="ORF">AWC31_27500</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854191.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27500"/>
    <dbReference type="EnsemblBacteria" id="KWX21505">
        <property type="protein sequence ID" value="KWX21505"/>
        <property type="gene ID" value="AFM11_25180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14894">
        <property type="protein sequence ID" value="ORX14894"/>
        <property type="gene ID" value="AWC31_27500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2397"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="258"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX14894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="519" mass="54628" checksum="EAB5B573DBA7C094" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGU5</accession>
    <name>A0A132PGU5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_23820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853432.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24325"/>
    <dbReference type="EnsemblBacteria" id="KWX21569">
        <property type="protein sequence ID" value="KWX21569"/>
        <property type="gene ID" value="AFM11_23820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2122"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="8">
        <location>
            <begin position="18"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="712" mass="76618" checksum="24165E5F60C1946E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH46</accession>
    <name>A0A132PH46_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853752.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23675"/>
    <dbReference type="EnsemblBacteria" id="KWX21669">
        <property type="protein sequence ID" value="KWX21669"/>
        <property type="gene ID" value="AFM11_24450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2250"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="186" mass="21314" checksum="5581F3FEA84D511A" modified="2016-06-08" version="1">MPNGNHDWTKPAALAIPKEGYFELERGRYGPVYPRTPACYGFSIIAKVKEGREEAVRAYGKQIEEAIADSPDVLAPLRLHYLRWVLFDVGSGLHFQYQGIFDTDFDKYTEDAVQLFSATGITTVFTNLEGFPEDWKENPDAFVKFVREHQCPSFLEYGEYPYVTADEIKKALRLKAAFSHMLDQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHP9</accession>
    <name>A0A132PHP9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_25330</name>
        <name evidence="6" type="ORF">AWC31_27650</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854262.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27650"/>
    <dbReference type="EnsemblBacteria" id="KWX21532">
        <property type="protein sequence ID" value="KWX21532"/>
        <property type="gene ID" value="AFM11_25330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14920">
        <property type="protein sequence ID" value="ORX14920"/>
        <property type="gene ID" value="AWC31_27650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2428"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX14920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="266" mass="28997" checksum="B1BE6C165C00A6A0" modified="2016-06-08" version="1">MDRDGIQIDDVSVVFDAPAGKVTAVTGITQHVPHSSFVSIVGPSGCGKSTLLAVISGLQKASTGQVRVAGKPVTGPDPSIGVVFQEDSTLPWRTVEENVAFAMEMIGVDKASRRQRAKDAIELVGLDGFEKSYPSMLSGGMRQRVALARTLAVQPEVVLMDEPFAALDQQTRLFLGAEVRQIWARTHQTIVFVTHDISEAILLSQQVWVMSYRPGSIIDVVDIDLPDERDASMVSTPQFNELQNRIWTSLQAESMRGFKQQEAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHR5</accession>
    <name>A0A132PHR5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21876">
        <property type="protein sequence ID" value="KWX21876"/>
        <property type="gene ID" value="AFM11_23250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2003"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453093" evidence="1">
        <location>
            <begin position="31"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="152" mass="14968" checksum="7312C639D9DD74B8" modified="2016-06-08" version="1">MAPVALVVALAAVGLAVFGLFRPSAGPADAAPAAVDASAGQGSKADVCSAFQTVRSAVSIQTHATSEGSAGAQAVAANARLSMLGGGAYLLERTGPSTPPELADAIQKFAGGLQDIAMHSLTGIGNDDPQQAERLRNADAANKSIADICAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHT3</accession>
    <name>A0A132PHT3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852654.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08980"/>
    <dbReference type="EnsemblBacteria" id="KWX21895">
        <property type="protein sequence ID" value="KWX21895"/>
        <property type="gene ID" value="AFM11_22230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1796"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453302" evidence="1">
        <location>
            <begin position="45"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="182" mass="18292" checksum="FBDD40F9146F17F0" modified="2016-06-08" version="1">MTSRSEVHTGGNRYGWRRVVAGAVAGSALAVGLLVGAAAPTAFAVPTTGADEPPAPKMSTDEALAIIAADYDTGAGGGQISQLIHEVLVLRAQGFKPSNANGRALSEALDKRPNQTPLVDALKSTVSFQRKLQAQAAGAVTPGGFTAGINQLPPGMAPDPTNPDNTGVFIGPTGGGVQQPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHU3</accession>
    <name>A0A132PHU3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23135</name>
        <name evidence="2" type="ORF">AWC31_27900</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX15126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853386.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21873">
        <property type="protein sequence ID" value="KWX21873"/>
        <property type="gene ID" value="AFM11_23135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15126">
        <property type="protein sequence ID" value="ORX15126"/>
        <property type="gene ID" value="AWC31_27900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1979"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX15126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="199" mass="21679" checksum="E4727872B1934551" modified="2016-06-08" version="1">MLELEVIDDPSAAVIALDPIRSRLLAELTEPASAAALAARVGITRQKVNYHLRALEQHDLVTVASERRWGGLTERLLVATASSYVVSPGALGPAAADPGRTGDRLSASYLIALSARAVREVGEMWRAARTKNKRLATLSIDTVIRFRTPADRAEFTRELSDAVLSLAARYHDDTAADGREHRLVVAAYPKPKTEEPKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIH6</accession>
    <name>A0A132PIH6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobalt ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_21870</name>
        <name evidence="6" type="ORF">AWC31_04675</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852465.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04675"/>
    <dbReference type="EnsemblBacteria" id="KWX22145">
        <property type="protein sequence ID" value="KWX22145"/>
        <property type="gene ID" value="AFM11_21870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10585">
        <property type="protein sequence ID" value="ORX10585"/>
        <property type="gene ID" value="AWC31_04675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1722"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX10585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="251" mass="26905" checksum="E968FAC2CE41435D" modified="2016-06-08" version="1">MTTPDIDIEGLHHVYPDGHVGLRGVDLAIASGERVAVLGPNGAGKTTLMLHLNGVLRATSGAVRITGLPVTRENLREIRRRVGLVFQDPDDQLFMPTVAQDVAFGPANFGVAGDELAARVRRALAQVSLTEHADRNPAHLSGGQRRRAALATVLACDAEVLVLDEPSANLDPVARRELAETLATLDVTMVIVTHDLPYAAQLCSRAVIMDEGRIVADGAIDTVLADADLLAAHRLELPWGFEVPVRRAVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ06</accession>
    <name>A0A132PJ06_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21080</name>
        <name evidence="2" type="ORF">AWC31_06445</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852183.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06445"/>
    <dbReference type="EnsemblBacteria" id="KWX22326">
        <property type="protein sequence ID" value="KWX22326"/>
        <property type="gene ID" value="AFM11_21080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09849">
        <property type="protein sequence ID" value="ORX09849"/>
        <property type="gene ID" value="AWC31_06445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1563"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX09849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="253" mass="25360" checksum="C622561E93FA2EBE" modified="2016-06-08" version="1">MDLGLSGKRFAVTGGTRGIGRAVVEGLLAEGAVVAYCARTPDAVAEAQAELTAGGATAVGSAVDVGDAAAVTEWVSGAADTFGGLDGVVANVSALAIPESAENWRTSFEVDLMGTVSLVDAALPHLVASGAGSIVTVSSVSGREIDFAAGPYGTFKAAIIHYTQGLAYNHAGKGVRANSVSPGNTYFPGGVWPSIEENNPELFAAALALNPTGRMATPQEVANAVVFLSSSAASFITGTNLVVDGALTRGVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ30</accession>
    <name>A0A132PJ30_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="17" type="ORF">AFM11_20785</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852077.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06200"/>
    <dbReference type="EnsemblBacteria" id="KWX22274">
        <property type="protein sequence ID" value="KWX22274"/>
        <property type="gene ID" value="AFM11_20785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1496"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013173">
        <property type="entry name" value="DNA_primase_DnaG_DnaB-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08278">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00766">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="263"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="440"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KWX22274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="632" mass="69137" checksum="A99801E91E52ED48" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJB7</accession>
    <name>A0A132PJB7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852248.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22354">
        <property type="protein sequence ID" value="KWX22354"/>
        <property type="gene ID" value="AFM11_21295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1605"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="141" mass="15439" checksum="BF1F13D1F0B28B97" modified="2016-06-08" version="1">MTVAVYSAEQVADILGLHVRTVRAYVRDGRLPAVRMGKQYRITEQDLRTFTGATVGKPTGKPHAHVSAVTHIHNVDRLTMDRVTTHLTAAAVGDSNRKAQLNFHSTYDETACRLTIFVDGDPEATAAVIGLIDGLTRQDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJC5</accession>
    <name>A0A132PJC5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_21685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852399.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04490"/>
    <dbReference type="EnsemblBacteria" id="KWX22112">
        <property type="protein sequence ID" value="KWX22112"/>
        <property type="gene ID" value="AFM11_21685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1685"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017535">
        <property type="entry name" value="Asparagine_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03104">
        <property type="entry name" value="trio_amidotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="601" mass="65120" checksum="4B699A9A7FE29F10" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJF2</accession>
    <name>A0A132PJF2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diaminopimelate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_20140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851908.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29970"/>
    <dbReference type="EnsemblBacteria" id="KWX22466">
        <property type="protein sequence ID" value="KWX22466"/>
        <property type="gene ID" value="AFM11_20140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1363"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="50"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="291"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="421" mass="44572" checksum="DDF9D0E6D237559F" modified="2016-06-08" version="1">MTTTAADLIGLFPPGSRPDTDGTLMVGGCRLDAIAEEFGTPAIVVNEDALRRRARDYLAAFRGRWPRSDVAFASKSFPCTAVQRVMAEEGLHLDVAGGGEILTALKAGADPARLVLHGNAKTDEELEIAVGHGVGLVVIDNFDDIDRLERIVGAGRRQACLVRVIPGVEAATHASQATGHAASKFGLSPEDARAAIARIEAGSRLRLDGVHTHVGSQLLNVDQLAAAVEPIARLGTFEVYDLGGGLGARYTYDEHPPGLDEYADAMTTQARALLPSGSRIIVEPGRSMVAASACTLYRVTTVKRGVVTHVAVDGGMGDNLEVSLTGQRFEATIVNRVGGGEPVSVVGRHCESGDQLVDGVALRDPVVGDLLAVPVTGAYCYTMSNQYNGARRVPVVFTCDGDARLVVRRDTWDDLLVRDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJM2</accession>
    <name>A0A132PJM2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851483.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22430"/>
    <dbReference type="EnsemblBacteria" id="KWX22549">
        <property type="protein sequence ID" value="KWX22549"/>
        <property type="gene ID" value="AFM11_18665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1070"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="136" mass="15257" checksum="8A5BF600C0C95BD1" modified="2016-06-08" version="1">MASPVSVLSEDESWRLLASVALGRFVTTIGTRLEIFPVNFVVQRRTVLFRTAEGTKLITAVMSDRVLFEADDHNIINGWSVIVRGTAELLESPEDIAAAERAQLLPWTATEKRRFVQITPKEISGRYFTFGSDQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJP8</accession>
    <name>A0A132PJP8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851527.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_14895"/>
    <dbReference type="EnsemblBacteria" id="KWX22568">
        <property type="protein sequence ID" value="KWX22568"/>
        <property type="gene ID" value="AFM11_18805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1096"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="117" mass="12529" checksum="7E81CE5624D34372" modified="2016-06-08" version="1">MDLLRNVVVYLHLIGFAVMVGAWVAEAAARRFQITKVMDYGITLSLVTGLVLAAPWPAGIELNYPKIGVKLVILIALGAVLGIGRVRERRTGRPVMPLFIAAGVLPLLAAGIAVLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJS1</accession>
    <name>A0A132PJS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_20710</name>
        <name evidence="14" type="ORF">AWC31_06125</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852051.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06125"/>
    <dbReference type="EnsemblBacteria" id="KWX22262">
        <property type="protein sequence ID" value="KWX22262"/>
        <property type="gene ID" value="AFM11_20710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09793">
        <property type="protein sequence ID" value="ORX09793"/>
        <property type="gene ID" value="AWC31_06125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1481"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="204"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="272"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX22262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX09793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="438" mass="47315" checksum="15E46630BA3981C1" modified="2016-06-08" version="1">MSGLLPLFGAIILVGFGGLFAAIDAALSTVSIARIEELTRDERPGAARLGRVVAERPRYINLVVLLRITCEVSATVLLASFLDGHLGVSWGLFAAAAIMVVTSFVAIGVGPRTVGRQNAYSIALVSALPLQAISVLLTPISRLLVLIGNALTPGRGFRNGPFASEIELREVVDLAQQRGVVADEERRMIQSVFELGDTPAREVMVPRTEMVWIESDKTAGQATSLAVRSGHSRIPVIGENVDDIVGVVYLKDLVQQTYYSTNGGRDTTVAQVMRSAVFVPDSKPLDELLSEMQRDRNHMALLVDEYGAIAGLVTIEDVLEEIVGEIADEYDTDEVAPVEDLGEREYRVSARLPIEDLGELYGLDLDEDLDVDTVGGLVAFELGRVPLPGAEVSWDGLRLRAEGGPDHRGRVRINTVLVSPTESPDENSRTRGGDHPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJX8</accession>
    <name>A0A132PJX8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ORF">AFM11_19320</name>
        <name evidence="10" type="ORF">AWC31_15405</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851691.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15405"/>
    <dbReference type="EnsemblBacteria" id="KWX22648">
        <property type="protein sequence ID" value="KWX22648"/>
        <property type="gene ID" value="AFM11_19320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17811">
        <property type="protein sequence ID" value="ORX17811"/>
        <property type="gene ID" value="AWC31_15405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1197"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140640">
        <property type="term" value="F:catalytic activity, acting on a nucleic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="79"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX17811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="203" mass="22030" checksum="57730AAC6BB52145" modified="2016-06-08" version="1">MFEGPVQDLIDELGKLPGIGPKSAQRIAFHLLSVEPPDIDRLTAVLGRIRDGVTFCAVCGNVSDDERCRICSDPRRDASLVCVVEEPKDVQAVERTREFRGRYHVLGGALDPLSGIGPEQLRIRELLNRIGERVDGVDVAEVIIATDPNTEGEATATYLVRMLRDIPGLTVTRIASGLPMGGDLEFADELTLGRALAGRRAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK64</accession>
    <name>A0A132PK64_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate--cysteine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19665</name>
        <name evidence="2" type="ORF">AWC31_15730</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851822.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15730"/>
    <dbReference type="EnsemblBacteria" id="KWX22740">
        <property type="protein sequence ID" value="KWX22740"/>
        <property type="gene ID" value="AFM11_19665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17867">
        <property type="protein sequence ID" value="ORX17867"/>
        <property type="gene ID" value="AWC31_15730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1267"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016602">
        <property type="entry name" value="UCP012666"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012666">
        <property type="entry name" value="UCP012666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX17867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="489" mass="55056" checksum="6762B3AAF05F161B" modified="2016-06-08" version="1">MGEEVKRTEYTRAHRQEYRRKVQLCLDVFETMLAQSKFEFERPLTGMEIECNLVDSQYQPAMSNREVLDSIADPAYQTELGAYNIEFNVPPRPLPGRAALELEDEVRASLNAAEAKANEDGAHIVMVGILPTLMPEHLSGSWMSESTRYQALNDSIFTARGEDMAIDIAGPERLSIQAASIAPESACTSMQLHLQVSPADFARNWNAAQVLAGPQLAVGANSPYFFGHQLWAETRIELFTQATDTRPDELKTQGVRPRVWFGERWITSIFDLFEENVRYFPSLLPELSDEDPVAELAAGRAPTLSELRLHNGTIYRWNRPVYDVVNGLPHLRVENRVLPAGPTVIDMMANSAFYYGLLRTLSEEDRPLWTKMSFAAAHHNFTAGAQHGMDARLYWPGLGEVTPDELILRQLLPLAHDGLRRWGVSGEVCDRYLGVIEGRAKTGQTGAAWQVSTVQDFQQSGRSRPEALAEMLRLYVQRMHSNEPVHTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKB4</accession>
    <name>A0A132PKB4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851115.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22778">
        <property type="protein sequence ID" value="KWX22778"/>
        <property type="gene ID" value="AFM11_17670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.889"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="450" mass="48731" checksum="028A718467457D6D" modified="2016-06-08" version="1">MTTSEPGTPKPTSRPTPGPTPGSTPRPGPPRPVPHPGRAASPVVAPAPTSDPHRFGRVDADGTVWLITGSGERVIGSWQAGDTESAYAHFGRRFDDLHTEVALLERRLTSGTGDARKVKSAAAALAETLPTAAVLGDVDALGARLTAILEQADAAAQNERAQRDEHRAAQTARKEALAAEAEDLAANATQWKAAGDRLREILDEWRTITGLDRKVDDALWKRYSAARETFNRRRGSHFAELDRNRLGARQAKEALCERAEELAGSTDWGATGAAFRDLLAEWKAAGRAAKDVDDALWQRFKAAQDTFFSARNAAHAERDAEFKANAAAKEALLSEAEKIDTTDLDAARAALRVIGDKWDAIGKVPRERAADLERRLRAVEKKIRDAPVGGVDPEAQARADQFRARAEQFEKQAEKAAAAGRTKDAEAARASAEQWRQWADAAAESLGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKC3</accession>
    <name>A0A132PKC3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nrdR</name>
        <name evidence="10" type="ORF">AFM11_17730</name>
        <name evidence="11" type="ORF">AWC31_11850</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851134.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11850"/>
    <dbReference type="EnsemblBacteria" id="KWX22788">
        <property type="protein sequence ID" value="KWX22788"/>
        <property type="gene ID" value="AFM11_17730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18688">
        <property type="protein sequence ID" value="ORX18688"/>
        <property type="gene ID" value="AWC31_11850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.901"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX18688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="149" mass="16764" checksum="06720C1DA1680813" modified="2016-06-08" version="1">MHCPFCRHPDSRVVDSRETDEGQAIRRRRSCPECGRRFTTVETAVLAVVKRSGVSEPFSREKVIRGVRRACQGRQVDDDALNVLAQKVEDAVRGLGTPEIPSHEVGLAILGPLRELDEVAYLRFASVYRSFSSAEDFEREIEALRAHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKD6</accession>
    <name>A0A132PKD6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloalkane dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851805.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15090"/>
    <dbReference type="EnsemblBacteria" id="KWX22724">
        <property type="protein sequence ID" value="KWX22724"/>
        <property type="gene ID" value="AFM11_19000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1134"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="48"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="302" mass="33076" checksum="3802533942046566" modified="2016-06-08" version="1">MQTLRTPDERFANLPEFPYAPKYCEVDDGEGGTLRMAWVEQGPAHAEPVLLLHGEPSWSYLYRRMIPILVAAGHRVICPDLVGFGRSDKPARIDDHSYARHVEWVRALAFDVLDMHRVTLVGQDWGGLIGLRLAAEHPERFANIVVANTGLPTGDIPMPEIWWQFRSAIQGLPTIEVGRFVASGCLRPMSDAVRAAYDAPFPDDSYCAGPRAMPGLVPTTPDDPAAAANRSAWEVLSASETPMLVAFSDGDPITGPMAAIFQREMRGARGIDHPVIAEAGHFLQEDAGEELAAAIVAFLRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKQ5</accession>
    <name>A0A132PKQ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851443.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22929">
        <property type="protein sequence ID" value="KWX22929"/>
        <property type="gene ID" value="AFM11_18160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.989"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="189" mass="20630" checksum="2CA404E985E72A3B" modified="2016-06-08" version="1">MPAMSRVERAFCKGMLWRGSGNAVLGSLPTDRLGRDVLEIGSGSGDIAARLRQARPDLAITATDFDPVMVRAATGRLRRYPDVTVQTADATDLPFADASFDSVLSCLMLHHIVEWEKAIAEIARVLRPGGVFAGYDLVRSPLATTIHRLDRSPFRLVNPGELESVCAEHGLTMRTQTRLAGQVMQFASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKT1</accession>
    <name>A0A132PKT1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_18630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851401.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12650"/>
    <dbReference type="EnsemblBacteria" id="KWX22903">
        <property type="protein sequence ID" value="KWX22903"/>
        <property type="gene ID" value="AFM11_18630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1063"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031326">
        <property type="term" value="P:regulation of cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="406" mass="42327" checksum="5B25D3CB0072DDBB" modified="2016-06-08" version="1">MTGHGLLVGRYELRRVLGYGGMAEVWDGWDHRLDRAVAVKMMHRAVAAQPDTRRRFESEARAAARLSHPNIVAVHDFGEHDGTPFIVMERLPGQTLADVIAQGPLSPQRAGAVLADVLFALAAAHGAGVLHRDIKPGNILIAANGSMKVADFGIAKTAGDVQTMAGQVVGTMAYMSPERITGAPASVSDDLYAVGVMGYEALVGFRAFPQDTPGAVVHAIMDNPPPPLSVVRPDVDPALAGTIDRAMARDPRHRFGSAEDMRSALACNPVAAFAGPALAGGPPRPATKVFTQAPMAPAATYFVPAAPKRRIPARTRKILAAAAIIAAFTVSVLAVAMDSSSTQAPDPVSTSTSVPTPSSAPPPPPPAPVVDQPRNEGNGKGEGNKDHKKNPGHGGGNGKGDKEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL29</accession>
    <name>A0A132PL29_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850803.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01485"/>
    <dbReference type="EnsemblBacteria" id="KWX23049">
        <property type="protein sequence ID" value="KWX23049"/>
        <property type="gene ID" value="AFM11_16915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.736"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="184" mass="19469" checksum="6AFD8E1E55A5244C" modified="2016-06-08" version="1">MSAVFDRQWAVCVYCASGPTHPELLALAGQVGSAIAERGWTLVSGGGNVSAMGAVARGARAKGGRTVGVIPKALVHRELADVDAAELVVTDTMRERKKEMEDRSDAFIALPGGIGTLEEFFEAWTAGYLGMHDKPLILLDPFGHYDGLLTWLRGLADTGYVSPEALDRLVVVSDVDAALDACAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLE5</accession>
    <name>A0A132PLE5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_15185</name>
        <name evidence="6" type="ORF">AWC31_15805</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850137.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15805"/>
    <dbReference type="EnsemblBacteria" id="KWX23171">
        <property type="protein sequence ID" value="KWX23171"/>
        <property type="gene ID" value="AFM11_15185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17881">
        <property type="protein sequence ID" value="ORX17881"/>
        <property type="gene ID" value="AWC31_15805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7149"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX17881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="191" mass="20774" checksum="EFE047E44836C76F" modified="2016-06-08" version="1">MTSQVSMESGVRERTRKAILDAAMTVLADQPAAALSDIAAAAGVGRSTVHRYFAERTDLLRALARHVHELSNAEIERADPTHGPADAALRRVVESQLDLGPIVLFVYNEPTILADPELAAYLDTGDEAIVEVLNRASTERPEYPPGWARRVFWALLQAGYEAAKQDGTPRHQIVDAIMASLTTGTIHLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLH4</accession>
    <name>A0A132PLH4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850196.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23198">
        <property type="protein sequence ID" value="KWX23198"/>
        <property type="gene ID" value="AFM11_15325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7179"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="361" mass="37854" checksum="2AE30CE2E8F127A3" modified="2016-06-08" version="1">MSIATLTTLAESTDAVLTAGNKLRGRQADADYAVELLTRRLEDCLDRFGQTRMQGFDGTGEPAAVDSVEDSLTIAASQLSMAAVALAADNDGDMGAGLDAALDDLTVTNATLQQLTAPSVAQGFETSIVRSADTPAAVKGLRAATEATLERVATDGGELCDRVIRTLPEVLPAISNTWEAIKKALNLEVLGEYFSRLARIALRLVAAALDRLATLIPSGFIDAARDRLRMLADRLAENEPTVAVFASILGIAVVERDTVVRLAREGLDKSKLDRATGQLTALGEQYGRYIGIASNVAGALKVLHSFSGLLVPVAPQLAVATASAHVLILVTVVAISLDFLDAGSQFGIVRGVRLTVEDATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLS6</accession>
    <name>A0A132PLS6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850615.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19915"/>
    <dbReference type="EnsemblBacteria" id="KWX22962">
        <property type="protein sequence ID" value="KWX22962"/>
        <property type="gene ID" value="AFM11_16405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.629"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="38265" checksum="E7ECCE4963F53C51" modified="2016-06-08" version="1">MEYRRVGNSGLTVSELSFGAATFGGRGEFFGAWGDTDVEQARAMVDLCLESGITMFDTADVYSDGASEEVLGAALRGRRDSVLISTKAALPTGPEDWGTSRSRLLRAVDDALQRLQTDRIDLFQLHAYDAFTPIDEVLQTLDVLVEQGKVRYTGVSNFSGWQLMKSLDLAEKHHRPRYVAHQVYYSLIGRDYEWELMPLGMSEGVGALVWSPLGWGRLTGKIRRGEPLPKHSRLHATADAGPPVDDELLYDVVDVLAAIAAETGKTIPQVALNWLLRRPTVSSVIVGARDERQLRDNLGAVGWRLDADQIARLDAASRREAPYPYFPYFRQEGFARLNPPIGANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM18</accession>
    <name>A0A132PM18_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetyl-CoA synthetase</fullName>
            <ecNumber evidence="4">6.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_16295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.16" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850579.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16925"/>
    <dbReference type="EnsemblBacteria" id="KWX23388">
        <property type="protein sequence ID" value="KWX23388"/>
        <property type="gene ID" value="AFM11_16295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7384"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="97"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="535"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="646" mass="70114" checksum="E40D040FCA8AD5FF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-06-17" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMA3</accession>
    <name>A0A132PMA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23445">
        <property type="protein sequence ID" value="KWX23445"/>
        <property type="gene ID" value="AFM11_14245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6956"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="102" mass="10787" checksum="338946B39EECFFDF" modified="2016-06-08" version="1">MDENSAITRHLSRYGIWGFIAAATNTLFLEFATWVLAPWLLYALLILPPIILTDLAISALVARCGGVAGQIGRGLMIGCIAAPASLAIFVPVFIIAHAIGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMC5</accession>
    <name>A0A132PMC5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850179.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15915"/>
    <dbReference type="EnsemblBacteria" id="KWX23192">
        <property type="protein sequence ID" value="KWX23192"/>
        <property type="gene ID" value="AFM11_15295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7173"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="165" mass="18748" checksum="1BBC1B886EB31553" modified="2016-06-08" version="1">MPRFILESADADFFTTAPHIFTYRERFAAPPQQVWESLVSDESLAAWGPSVKEVNWLSPRPFGVGTMREVVLAPGFARVHETFFRWDDGRRYSFTVDEATIPSLRRFAEDYLVEPAGEGQTQFTWIVAIEPKPAFALPFRVLAPAVKATFGRLASDGQRYFARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMG8</accession>
    <name>A0A132PMG8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFM11_14780</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849947.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18120"/>
    <dbReference type="EnsemblBacteria" id="KWX23530">
        <property type="protein sequence ID" value="KWX23530"/>
        <property type="gene ID" value="AFM11_14780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7067"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="283"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KWX23530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="361" mass="40173" checksum="A4BEC7C0A2B8F4EF" modified="2016-06-08" version="1">MFNWFSLDIIYYPVSAIMWVWYKAFAFLLGPSNFFAWALSVMFLVFTLRAILYKPFVKQIRTTRQMQELQPQIKALQKKYGKDRQRMALEMQKLQREHGFNPILGCLPMLAQVPVFLGLYHVLMSFNRTQTGIGRLGLSVEENRSLPNYLFSATDVGHFLDANLFGAPLGATMIQQHGLEAFTEFNRVAVIAVGLPIMILAGIATHFNSRASVARQSPEAASNPQTAMMNKLALYVFPLGVVVGGPFLPLAVIMYWLANNIWTYGQQHYVFGKIEKEEEAKKAEALERRAANAPAPGAKPNRARKQTPSTSAGPDVESTAAEIESSAATDNKADDPKTDTTGTTAVSRTPKPGARPKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMM9</accession>
    <name>A0A132PMM9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recF</name>
        <name evidence="10" type="ORF">AFM11_14750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849934.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18150"/>
    <dbReference type="EnsemblBacteria" id="KWX23524">
        <property type="protein sequence ID" value="KWX23524"/>
        <property type="gene ID" value="AFM11_14750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7059"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX23524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="384" mass="41752" checksum="324B924BC9375C0D" modified="2016-06-08" version="1">MHVRHLGLTDFRSWAHVELDLEPGRTVFVGPNGFGKTNLIEALWYSATLGSHRVASDAPLIRAGAERAIVSTIVVNDGRELAVDLEITSGRANKARLNRSPVRSAREILGVLRAVLFSPEDLALVRGDPGDRRRYLDELATTRRPSIAGVRADYDKVVRQRTALLKTAAGARYRGDRSVLDTLDVWDGHLAAHGAALIAARVALVEQLHPEVEKAYQLLAPASRPAAIRYRSSVEAIENAPAGEGVEFYEAALLDALARRRDAELERGVCLVGPHRDDLELRLGDQPAKGFASHGESWSMALALRLGAYELLRSDGADPVLLLDDVFAELDSARRRALATVAGAAEQVLVTAAVAEDIPEDWDACRIEVRMTEEDGGRVSEVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMP7</accession>
    <name>A0A132PMP7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23573">
        <property type="protein sequence ID" value="KWX23573"/>
        <property type="gene ID" value="AFM11_15060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7123"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="221" mass="23733" checksum="DD28FBA9D9388BE0" modified="2016-06-08" version="1">MMIIGYRPADPAAARRALPSRLEPHPDGVVLLNLWAAEDPGRSSGMGTYGRLSCGYIAPEVSGYDTQTSDGNATGHGRFFAHHWLESAGMRSFAEASCGNRADIGYVQQSEPHPGELVQELYVDGKVVVRTTSSVGTERLATIGGHLNYFTTFAGPDDREQIARVAVPFVADVKEAQVKSIEWLFDADHPAAALAPSSDPDVASVLYGDITWAPFTVAEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMS1</accession>
    <name>A0A132PMS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849868.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23497">
        <property type="protein sequence ID" value="KWX23497"/>
        <property type="gene ID" value="AFM11_14560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7021"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="235" mass="26307" checksum="10AFA47B939B713F" modified="2016-06-08" version="1">MRRPDGELILLGTLPVVAIIWISAFFLFPGFVHPMSPNMSAEQVAGLYQDDTARIRYSMILFNWFGVGLIPIVILLAMQVRRMAHRTPILSYSLIAAAGGPPALFLIANMFWLLGSFRPERSPELTQVLNDLAWLTFTLLVPYLIAQCLLLALAIYWDQQEQPVFKPWVAYFNLVVAAALVPATFTALSFDGPFAWDGVLSFWLKNIAIAVWILVMGVVLAQSIKQQRTQDKVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN30</accession>
    <name>A0A132PN30_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_13290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849313.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03575"/>
    <dbReference type="EnsemblBacteria" id="KWX23749">
        <property type="protein sequence ID" value="KWX23749"/>
        <property type="gene ID" value="AFM11_13290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6751"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="510" mass="54766" checksum="D4D24711CDACC467" modified="2016-06-08" version="1">MPLNTGDVFAGYTIQRLLGSGGMGEVYLAQHPRLPRQDALKILPISLTGDTQYRQRFNREADIAALLWHPHIVGLHDRGESDGQLWIAMDYVDGTDASRFVREHHPKGMPLADAIEIVTAIADALDYAHTRNLLHRDVKPANILLTGSGDVADPAPRVRTKRRILLADFGVARRVDDISGLTATNMAVGSMAYSAPEQLLGQDMDGRADQYALAASAFHLLTGRSPFHHSNAAVVISKHLSEPPPRLSASRPELAHLDDVMAKGLAKDPAARYAQCSDFANALASAAPKPAPRPPTVARPVVSPPPPPKPAPQPQPPAPHISSPSISTPPPPAAWSFTPPVLQPRPRQKRSAARVLVSATLAVLLVCAIGFAATQFMRSAPTTSTTPQWQPYVDAAKTLAVDLVTVNADTVDADIERVIDATTGEFQDRLRSGSAKMKQGTVDEGKETEADVTGAGVESFTSDEAVVLVSVTTKTTYNTNAPREDAVQRLAITMVKVGDEYKASKMEFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNI9</accession>
    <name>A0A132PNI9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849517.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23834">
        <property type="protein sequence ID" value="KWX23834"/>
        <property type="gene ID" value="AFM11_13825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6861"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="226" mass="24260" checksum="F40969C08344E9E9" modified="2016-06-08" version="1">MRARGGRSSVTRADMAVAEEIRTLILRGELVPNQRLVEADLAEQFGASRTAVRTALGELAVQGLVEREQNRGARVRVISFDEAIEIAEVRRALESLCAGKAAAVVTDDEIAELKAIGEAMEQAVAGGDLGGYSAKNRELHARIHQISGQRTALSLIERLRAQSVRQQFALAMKPGRPSVSLGEHLAIIDAIAHRDPAAAEHAMTVHLNSVVAAMREVHAQQPTSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNL5</accession>
    <name>A0A132PNL5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848082.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30725"/>
    <dbReference type="EnsemblBacteria" id="KWX23931">
        <property type="protein sequence ID" value="KWX23931"/>
        <property type="gene ID" value="AFM11_11175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6312"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="56"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="546" mass="58783" checksum="A388C16C9B0DEACD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNP9</accession>
    <name>A0A132PNP9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl-peptide hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acylaminoacyl-peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_11130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23923">
        <property type="protein sequence ID" value="KWX23923"/>
        <property type="gene ID" value="AFM11_11130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6303"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="6">
        <location>
            <begin position="405"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="625" mass="67283" checksum="0968AB9E4C2DEA85" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPE9</accession>
    <name>A0A132PPE9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F420_oxidored domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848019.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31220"/>
    <dbReference type="EnsemblBacteria" id="KWX23912">
        <property type="protein sequence ID" value="KWX23912"/>
        <property type="gene ID" value="AFM11_11035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6283"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="251" mass="26003" checksum="8269C80A90D30633" modified="2016-06-08" version="1">MRRSTVAPSSKSPAATDDVVSETVSILGGTGNLGFGLALRLGVAGYTVCLGSRDADRAQRAAELARERVGGGEFIGCRNGEAVARADRLVVAAVPFASHVAILRSVADQWRPGQVLLDTTVPLATAVGGRPTHLIDPWHGSAAQQARSAIDDQVALASGLHTISAAALRNLARPLDQDTLICGEPEAKQVAAAALERIAGLRVVDAGSLEMSRLLEGLTPVLIGINIRHKTHAGIQVTHLGTSTKQQAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPF4</accession>
    <name>A0A132PPF4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_12255</name>
        <name evidence="5" type="ORF">AWC31_09725</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848882.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09725"/>
    <dbReference type="EnsemblBacteria" id="KWX24185">
        <property type="protein sequence ID" value="KWX24185"/>
        <property type="gene ID" value="AFM11_12255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09214">
        <property type="protein sequence ID" value="ORX09214"/>
        <property type="gene ID" value="AWC31_09725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6530"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX09214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="209" mass="22411" checksum="16BF5C7D6FB86121" modified="2016-06-08" version="1">MFDQLLRTEDEALIAARESAPAADMPPIEVSAQYGKLLSLLATISGARRVLEIGTLAGYSTINLARGIGADGHVVTLEYEPRHAEVARANLQRAGVADRVEIIVGAALDTLPTLAERGDVFDFIFIDADKENNVSYVEWAIKLGRPGSVIVVDNVTRFGRVLEPAADDPQALAVHDMLELMGNHPRLDAAAIQTVGAKGWDGFAVALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPF7</accession>
    <name>A0A132PPF7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09485</name>
        <name evidence="3" type="ORF">AWC31_05740</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847129.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05740"/>
    <dbReference type="EnsemblBacteria" id="KWX24220">
        <property type="protein sequence ID" value="KWX24220"/>
        <property type="gene ID" value="AFM11_09485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09728">
        <property type="protein sequence ID" value="ORX09728"/>
        <property type="gene ID" value="AWC31_05740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5934"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="42"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="294" mass="32372" checksum="CF4A01FAD5705745" modified="2016-06-08" version="1">MSVPARPAPLFADIDDVARRLAETGYLPDTATATAVFLADRLGKPLLVEGPAGVGKTELARAVAQSTGSELVRLQCYEGVDEARALYEWNHAKQILRIQAGQGEGADWDRTKDDVFSEEFLLTRPLLTAIKRTDPTVLLIDETDKADIEIEGLLLEVLSDFAVTVPELGTITAERPPFVVLTSNATRELSEALKRRCLFLHIDFPDPDLERRILLSRVPELPEHIATELVRIIGVLRGMQLKKLPSVAETIDWGRTVLALGLDTIDDQMIAATLGVVLKHQSDQQRAAGELRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPL9</accession>
    <name>A0A132PPL9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847339.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05345"/>
    <dbReference type="EnsemblBacteria" id="KWX24289">
        <property type="protein sequence ID" value="KWX24289"/>
        <property type="gene ID" value="AFM11_09880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6014"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="263"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="454"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="523" mass="56324" checksum="9BE4665C4EC60ED5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPZ7</accession>
    <name>A0A132PPZ7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_10210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847515.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18655"/>
    <dbReference type="EnsemblBacteria" id="KWX24344">
        <property type="protein sequence ID" value="KWX24344"/>
        <property type="gene ID" value="AFM11_10210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6080"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="4">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="5">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="400" mass="41840" checksum="F37749257E0BEE1F" modified="2016-06-08" version="1">MSAKEFLVPDLGEGLQDATITSWNVAVGDTVELNQTLCTVETNKAEVEIPSPYAGQVLELGGAAGETLAVGSLLVRIGTVESSASPVPAATNGIGTQRKPVLVGYGADDAMDVSRRATAPSTPPTVRARAKPPVRKLAAELHVDLDALSPGSGPEGIVTRDDVLAAAGSSELRAVGGVQAEMARRMALSRHEIPDAHARVDVDGAALLRLRDSIRAIDAELPVTPFVLTLRLLTIALRHHPILNSTWVETTGGPQIHQHPSVHLGFGVAAPRGLLVPVVRGADRLTTRELAGVVARLVEGARAGTLKPPELTGSTFTVSNFGALGMDDGVPVINYPEAAILGMGSLKPRPVVIDGAVVARPTMSLTCAFDHRVADGAQVGAFLRELRQLIEEPELALLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ07</accession>
    <name>A0A132PQ07_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847750.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19200"/>
    <dbReference type="EnsemblBacteria" id="KWX24419">
        <property type="protein sequence ID" value="KWX24419"/>
        <property type="gene ID" value="AFM11_10685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6177"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010753">
        <property type="entry name" value="DUF1330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07045">
        <property type="entry name" value="DUF1330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1330" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="96" mass="10329" checksum="4172F167E3C66D76" modified="2016-06-08" version="1">MAKGYVIITEDIKDPAGMGEYAKLAQQAMAGATIVAVDQKPEVVEGTWHGTQTVVLEFESVDAAREWYYSDAYQKAAKVRQSAADCNGVIISGFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ57</accession>
    <name>A0A132PQ57_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847771.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24425">
        <property type="protein sequence ID" value="KWX24425"/>
        <property type="gene ID" value="AFM11_10730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6185"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="119" mass="13754" checksum="F75ACD899212E3E4" modified="2016-06-08" version="1">MKAIGSRRRSQPAPPWAIFADLCDPNRQPVRPWLHLRDDEMPPAIVESARPHRVVWSSLWGRRPDAQVRFDLEAEPGGGTYLRWTLYVDDPVPDAEMTRHMCKRIGELVNANLRHTYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ87</accession>
    <name>A0A132PQ87_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847110.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05780"/>
    <dbReference type="EnsemblBacteria" id="KWX24212">
        <property type="protein sequence ID" value="KWX24212"/>
        <property type="gene ID" value="AFM11_09445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5926"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="18159" checksum="130A87E0B64CC4BE" modified="2016-06-08" version="1">MSQARLGTIRHDIVVDAPLERAFRVFTEQFGDFKPREHNLLAVPIAETVFEARPGGRIYDRGVDGSVCAWARVIALDPPNRVVFSWDIDPTWQIETDPARCSEVEVRFVAESETRTRVELEHRHIDRHGDGWEAVVSGVDGDAGWPLYLSRYGALVESVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQB4</accession>
    <name>A0A132PQB4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_07405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845938.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24513">
        <property type="protein sequence ID" value="KWX24513"/>
        <property type="gene ID" value="AFM11_07405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5331"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="30693" checksum="43A1CDE11A4E22FF" modified="2016-06-08" version="1">MKVHRAVIAAAGLGTRMFPITKTIDKAMLPIGTRPAIDLIIGECQAAGVDQIAVVVRAGSTQVQDYYTPDPTLESLLARHSWQSKGEVLNDIGRGIDFQFFYQRLDVDDYGTAVPLLLVRDFVGEQPFYYISGDDVLIDTAYTSTLLNLAELVNVGGSGLVARTCDWAEAQRYGVLDVTRRDGRLVLTGLREKEIPSDATRNPLVNISRYVLPATVIDLIRDLPVDPRTGERRVTDALLRLMDSGEPPLVYATDGQYFDIGDHRGLLAANNFVDTRGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQF9</accession>
    <name>A0A132PQF9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LEH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19235"/>
    <dbReference type="EnsemblBacteria" id="KWX24504">
        <property type="protein sequence ID" value="KWX24504"/>
        <property type="gene ID" value="AFM11_10720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013100">
        <property type="entry name" value="LEH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07858">
        <property type="entry name" value="LEH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LEH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="119" mass="13502" checksum="40B3CD5A9F0F8E07" modified="2016-06-08" version="1">MVRAEIAAWGSNDIDEIMSHFAEEATFDIGPDWPRLSGRDAIHEMMKVFFAGGKCVDLEIRHLAVDGDVVLMERRDHWIVDGKQMSWPVMGAYEVKGEKITAWREYFYPPKDPSADGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQK3</accession>
    <name>A0A132PQK3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_07940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846197.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24540"/>
    <dbReference type="EnsemblBacteria" id="KWX24603">
        <property type="protein sequence ID" value="KWX24603"/>
        <property type="gene ID" value="AFM11_07940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5438"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="372" mass="39927" checksum="78AE1929F99C3A29" modified="2016-06-08" version="1">MAAVPDDFIAGLEGVVAFTTEIAEPDKDGGALRYRGVDIEELVTRRVTFGDVWGLLVDGSFGTGLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYAPILDVDESTAREQLARASVMALSYVAQSARGIYQPAVPQRMIDECPTVTARFMTRWQGDPDPKHVEAIDAYWVTAAEHGMNASTFTARVIASTGADVAAALSGAVGAMSGPLHGGAPARVLPMIEEVEKSGDARAVVKAILDSGDKLMGFGHRVYRAEDPRARVLRATAQRLGAPRYEVAVALEQAALAELRERRPDRAIETNVEFWAAVILDFAQVPATMMPAMFTCGRTAGWCAHILEQKRLGKLVRPSAIYVGPEPRSAESVAGWDKIAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQT4</accession>
    <name>A0A132PQT4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846438.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24683">
        <property type="protein sequence ID" value="KWX24683"/>
        <property type="gene ID" value="AFM11_08410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5530"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="92" mass="8993" checksum="B6C7E3EED275A66F" modified="2016-06-08" version="1">MKGDLYADGAGLNAAAHSSLDIADALKSSAVETAYSVGQPSEAGVIALDAALAAMRARQSSRAGGQSAGMDAASAVYTNTDSASAGDITKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR46</accession>
    <name>A0A132PR46_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="6">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purD</name>
        <name evidence="9" type="ORF">AFM11_08780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846611.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13590"/>
    <dbReference type="EnsemblBacteria" id="KWX24744">
        <property type="protein sequence ID" value="KWX24744"/>
        <property type="gene ID" value="AFM11_08780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5604"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="107"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="422" mass="43146" checksum="95A68CB2429B838C" modified="2016-06-08" version="1">MRVLVIGSGAREHALLLALRRDPEVEELAVAPGNAGTEVIADQYDVDITSGEAVVKLAQRIGSDLVVVGPEVPLVLGVADAVRAAGIACFGPTKDAARIEGSKAFAKDVMAAAGVRTAGSEIVDNPAHLDAALDRFGPPAGQAAWVVKDDGLAAGKGVVVTADRDAARAHAASLLDSGHPVLLESFLDGPEVSLFCVVDGETVVPLLAAQDFKRVGDGDTGPNTGGMGAYAPLPWLPESVTTQIVDQIVKPVAAELVARGSSFSGLLYAGLAITSNGPAVVEFNCRFGDPETQSVLALLESPLGQLLRAAASGELASFGELQWHDGYAVTVVLAAENYPGRPRVGDVIHGSEADGVLHAGTARRDDGAVVSSGGRVLSVVGTGADLPAARDAAYTLIKSIRLPGSHFRTDIGLAAAEGRISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR94</accession>
    <name>A0A132PR94_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24868">
        <property type="protein sequence ID" value="KWX24868"/>
        <property type="gene ID" value="AFM11_09215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5691"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="3">
        <location>
            <begin position="472"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="704" mass="76633" checksum="2E84190524728A80" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRC4</accession>
    <name>A0A132PRC4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24876">
        <property type="protein sequence ID" value="KWX24876"/>
        <property type="gene ID" value="AFM11_05350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4259"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="167" mass="18596" checksum="67964D690BDA734D" modified="2016-06-08" version="1">MTMRRYASSGSYYWKTPGEGAWLPREWAYTPDEFDSVSVLTTTERMSRWFMRTLLRADAFAERVARERLAMTAVRRHEQAHALSRAGSRTRNATVVTVHDSGIAVDARSSPTAQAIADAAVVTVGIEIDGDRRDAVTLLPRTVAIAPAQEFLVVDHPDDPIPLWVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRD6</accession>
    <name>A0A132PRD6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_05440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844987.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12815"/>
    <dbReference type="EnsemblBacteria" id="KWX24890">
        <property type="protein sequence ID" value="KWX24890"/>
        <property type="gene ID" value="AFM11_05440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4277"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014343">
        <property type="entry name" value="Ectoine_EhuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03005">
        <property type="entry name" value="ectoine_ehuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="254" mass="28389" checksum="4F20EBC65F3ABB1D" modified="2016-06-08" version="1">MVRFAGVVKRFGDHVVLDGLDFSVRPGEFVTLIGPSGSGKTTILRLLMTLEQVTEGRIYVDGECLSHMIRRGREVPADDNHQRQLRKRIGMVFQQFNLFPNMSVLHNITEAPIHTLNLPRDEAEDRAQRLLELVGMPEKADAHPSELSGGQQQRVAIARALAMKPDVLLLDEVTSALDPELVAGVLSLLKDIAESTDITFLCVTHEMDFAREVSDRVLMFDGGRIVEDAPPDKLFTAPEHERTRTFLRAVLERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRJ6</accession>
    <name>A0A132PRJ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GFO_IDH_MocA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24817">
        <property type="protein sequence ID" value="KWX24817"/>
        <property type="gene ID" value="AFM11_09210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5690"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="249" mass="27648" checksum="BA64848F656FB9AC" modified="2016-06-08" version="1">MISSDPAELLDSVAAPIVVVATPRDTHADLAELALRARRDVFVEKPMATEPADCTRLTSIADAEGVALFTGFTYLYHGAYACLRDAIAANEIEQLTFTWNRPGLRGPTEWELLPHDLAIAIGLTGHTPARIRLKVTGGRVQCRWALDDNRIVQIEHDGGGSGPKDKRVRVVTKRGDVWEWRGNHLAMWDSATETSEPDLAIDYSPKEPLVREVKWFLEHRADRSAMRADAALSTSVTELINRALTEKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRM2</accession>
    <name>A0A132PRM2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08465</name>
        <name evidence="4" type="ORF">AWC31_00320</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000001">
        <property type="protein sequence ID" value="ORX19338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846467.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24692">
        <property type="protein sequence ID" value="KWX24692"/>
        <property type="gene ID" value="AFM11_08465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19338">
        <property type="protein sequence ID" value="ORX19338"/>
        <property type="gene ID" value="AWC31_00320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5541"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453569" evidence="2">
        <location>
            <begin position="31"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX19338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="144" mass="14028" checksum="75D6E138D86B6321" modified="2016-06-08" version="1">MKKLIVLGAGAAVAASAAVSSLLGAGIAAAAPDVVGQTYSDAATAIEDDGGTPKVAVTVGSKLSQDDCIVTNAWDAPFMRDDGGEFAHADGEVMVALNCDGGHATATNPGASVASPAGREAKAAADEAAAAEEEELAEASTPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRU3</accession>
    <name>A0A132PRU3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_06410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29265"/>
    <dbReference type="EnsemblBacteria" id="KWX25056">
        <property type="protein sequence ID" value="KWX25056"/>
        <property type="gene ID" value="AFM11_06410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4474"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="219" mass="24338" checksum="5C7F70E18FA12693" modified="2016-06-08" version="1">MVRPRRGSAMVATVDETALIQALRNGDETAFAMLVDQHAPAMLRVARGYVPSAEIAEEVVQEAWIALIKGIGKFEGRSSLRTWLFTVMINIAKSRGVRERRDADAEIAAFTGTTVDPARFRPGSDPWPGHWKADAAPSAFPETPEGSLLGTELMELARRELEKLPERQRMVVTLRDMLGFDSAEVCRLLDLTVANQRVLLHRGRAAVRQALEDYLQEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRU4</accession>
    <name>A0A132PRU4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_06425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845306.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29250"/>
    <dbReference type="EnsemblBacteria" id="KWX25059">
        <property type="protein sequence ID" value="KWX25059"/>
        <property type="gene ID" value="AFM11_06425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4477"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="275" mass="29783" checksum="13C0F828680B854E" modified="2016-06-08" version="1">MSVTDDNHFVLVDRPRPDVALVTLNRPERMNSMAFDVMVPLKRVLEELRYDNSVRVVVLTGAGRGFSSGADHKSAGSVPHVDGLTRPTYALRSMELLDDVILALRRLHQPVIAAVNGAAIGGGLCLALACDIRVAADGAYFRAAGINNGLTASELGLSYMLPRAIGASRAFEIMLTGRDVDADEAQRIGLVSRSVPDDELLDTCYQMAERIAAFSRPGTELTKRTLWSGLDASSLEGHMQAEGLGQLYVRLLTANFEEAVAARAEKRAPIFTDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSN2</accession>
    <name>A0A132PSN2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_03265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843915.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21820"/>
    <dbReference type="EnsemblBacteria" id="KWX25320">
        <property type="protein sequence ID" value="KWX25320"/>
        <property type="gene ID" value="AFM11_03265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2528"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="71"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="308" mass="32940" checksum="4A8C658B077491F3" modified="2016-06-08" version="1">MTGPTPEDLRLALRAATLYYLDGLTQAEIASRLGVSRPTAGRLVAKAKANGLVRIEVVVPPDISDDLHADEERELERRFGLTEAVVASNASRAGAALLMRRIGADEVLGFTWGPEQVGVASALVPGVASCRAVVQLDGAMSTAAYQTGTEQILTRCADTLRAETFRLPAPLYADPATVVSMREDSVISRTLDAGRRAEVMLFGVGAVSTSTTLFEGSFLDIRMLDELVSLGAVGEIGGRFFNAYGEPVHDELQQRAMSVPLEDIRTCEKTILVSGGASKHQAILGALRGKLARLLVCDIDCARWLLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSQ8</accession>
    <name>A0A132PSQ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_03690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844149.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21465"/>
    <dbReference type="EnsemblBacteria" id="KWX25386">
        <property type="protein sequence ID" value="KWX25386"/>
        <property type="gene ID" value="AFM11_03690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2614"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="241" mass="26806" checksum="9FD47CC196CFE00F" modified="2016-06-08" version="1">MVKAGVVDARQERADRILDTAKDLLLRWGYRRIRIDEVAKRAGVGKGTVYLHWRTREQMLSAVGTRETAEMVDAVVAALRVDSAEVAPHRLMRRIFVEAMSRPVLRAIYTQDIETVDALVTDGAQKAMGAANFAGWREYLTIVHEYGLLGSGLRPEDVHYPLTASVFGFFAAEPMLPGELGLTLDEKADQLASTLRRAFEPARSPARKHLDAAAAKVIAHYERLAEEFRALTYGGDQDDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSZ9</accession>
    <name>A0A132PSZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_03755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844185.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25394">
        <property type="protein sequence ID" value="KWX25394"/>
        <property type="gene ID" value="AFM11_03755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2628"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013228">
        <property type="entry name" value="PE-PPE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08237">
        <property type="entry name" value="PE-PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453263" evidence="2">
        <location>
            <begin position="33"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="PE-PPE" evidence="3">
        <location>
            <begin position="388"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="725" mass="76053" checksum="E8AC8AAF053FAB71" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT46</accession>
    <name>A0A132PT46_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_04400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844482.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20745"/>
    <dbReference type="EnsemblBacteria" id="KWX25493">
        <property type="protein sequence ID" value="KWX25493"/>
        <property type="gene ID" value="AFM11_04400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2756"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="256"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="477" mass="50119" checksum="792B904C5F82E821" modified="2016-06-08" version="1">MWRRVLLVLVIYSAIAVLGLAIPLAATLGRERLQRFGENRFAAASHFADLASRRDGYQDVDLQQAVDRYYALYGEPVVIVDRSGNPRASAGPGTNSPDVAGAVSEALRNQRSRVPGTLTPWSPAQVLIAVPVGTGTQVDGAVVLAASTAAAKGDVTRAWLLIVAGAAALLAVASLIALALSRWTIRPLTELAARVSSLGHRVLDHAPASGDHDNGQPDTVGRYAGPQEVRRLSAVFDAMARDVEAAATAQRRLVADSAHALRNPLAALRIRLDTLGMALPESSAAAHRKAAAEVDRLEGIVADLLALATAETRPDPDGEIRSADVRAAIADRHEFWSAALAEAGIEAGVTDESDDPLYATIPDRDLAQILDITLSNAVKYAGTGTHVDLGARRIGDDIAVWVEDNGRGVSEQDLPLISTRFYRAANTVGQGTGLGLSIARALTERAGGVFGVGPGRSGGLRIDLRLPAADRDEPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTS4</accession>
    <name>A0A132PTS4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="10" type="ORF">AFM11_00075</name>
        <name evidence="11" type="ORF">AWC31_33180</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036429170.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33180"/>
    <dbReference type="EnsemblBacteria" id="KWX25736">
        <property type="protein sequence ID" value="KWX25736"/>
        <property type="gene ID" value="AFM11_00075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11545">
        <property type="protein sequence ID" value="ORX11545"/>
        <property type="gene ID" value="AWC31_33180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.15"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX11545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="156" mass="17586" checksum="3803E4F0D9CF7AE5" modified="2016-06-08" version="1">MPRKGPAPKRPLVNDPVYGSQLVTQLVNKVLLQGKKSLAERIVYGALEQARDKTGTDPVVTLKRALDNVKPALEVRSRRVGGATYQVPVEVRPDRSTTLALRWLVSFSRQRREKTMVERLANEILDASNGLGASVKRREDTHKMAEANRAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTW7</accession>
    <name>A0A132PTW7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844938.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25714">
        <property type="protein sequence ID" value="KWX25714"/>
        <property type="gene ID" value="AFM11_04945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2870"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="277" mass="30064" checksum="4DC6DAD0EC9E4450" modified="2016-06-08" version="1">MSEPLLDRDSGVPLYAQIRDVLRGQILGQHIAPGEHLPGELELQERFGVARSVIRQALSELADAGLIRRERGRGSVVVPTRLHHRRAEQAGGLSRQLAAAGEHLRTVVLDLRAATAPDAAVPALRTADAWRIERLRFVDEEPLVFMRSWVSRELFPDLTADAIEGSLLGYMRSTGVVPVGGPRQLRAVPADPTVADHLGIDVGTPVLLLQALTNDDQGRGLEWSTLWHQPSTVFDVDAKVETRVDAPADPAAPGSPDFDRVRELIAELASIIGPGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTX0</accession>
    <name>A0A132PTX0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842213.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33495"/>
    <dbReference type="EnsemblBacteria" id="KWX25788">
        <property type="protein sequence ID" value="KWX25788"/>
        <property type="gene ID" value="AFM11_00380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.77"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="150" mass="15383" checksum="A3BD2DB35C82CD18" modified="2016-06-08" version="1">MHRIHRITLDDALPLLAAGRAKAEEIGVKQTLCICDDGGNVLALHRLPGARLTGVDIAIAKAFTAAGHERATHLFNEPPNGPALPGNEAFGISHMLPGKFAIFVGGFPLVFDGQIVGGVGISGGNGQQDKAVGAAILAEFDALTASVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTZ7</accession>
    <name>A0A132PTZ7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="7" type="ORF">AFM11_00290</name>
        <name evidence="8" type="ORF">AWC31_33400</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842170.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33400"/>
    <dbReference type="EnsemblBacteria" id="KWX25775">
        <property type="protein sequence ID" value="KWX25775"/>
        <property type="gene ID" value="AFM11_00290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11586">
        <property type="protein sequence ID" value="ORX11586"/>
        <property type="gene ID" value="AWC31_33400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.59"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX11586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="98" mass="11178" checksum="EE0197BA6F36F34F" modified="2016-06-08" version="1">MAETKGPKHTPRTEKPRGRRKTAIGYVVSDKMQKTIVVELEDRKSHPLYGKIIRTTKKVKAHDENGDAGIGDRVSLMETRPLSATKRWRLVEVLERAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTZ8</accession>
    <name>A0A132PTZ8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplO</name>
        <name evidence="10" type="ORF">AFM11_00475</name>
        <name evidence="11" type="ORF">AWC31_33590</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842257.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33590"/>
    <dbReference type="EnsemblBacteria" id="KWX25806">
        <property type="protein sequence ID" value="KWX25806"/>
        <property type="gene ID" value="AFM11_00475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11620">
        <property type="protein sequence ID" value="ORX11620"/>
        <property type="gene ID" value="AWC31_33590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.96"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX11620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="147" mass="15463" checksum="149C4354E99BADD8" modified="2016-06-08" version="1">MSVIKLHDLKPAAGSKTAKTRVGRGEGSKGKTAGRGTKGTKARKNVPVTFEGGQMPIHMRLPKLKGFKNRFRTEYEVVNVGDISKAFPEGGTVGVDELVAKGLVRKNTLVKVLGDGKLTVKVDVTANKFSGSAREAITAAGGSVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUP3</accession>
    <name>A0A132PUP3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_01940</name>
        <name evidence="4" type="ORF">AWC31_34720</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842997.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34720"/>
    <dbReference type="EnsemblBacteria" id="KWX26033">
        <property type="protein sequence ID" value="KWX26033"/>
        <property type="gene ID" value="AFM11_01940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11812">
        <property type="protein sequence ID" value="ORX11812"/>
        <property type="gene ID" value="AWC31_34720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.398"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="461" mass="50121" checksum="3CF27A0A39A7DD4A" modified="2016-06-08" version="1">MTSVDITEATSTDLGAKANRHLWGHFARHGEGITPPIITRGEGVRIFDDRGKSYIDGLSGLFVVQVGHGRKELAEAAAKQAETLSFFPLWSYATPPAIELAERVASFAPGDLNRVFFTTGGGEAVESAWKLAKQYFKLTGKPGKHKVVSRSIAYHGTPQGALAITGIPAFKAPFEPLTPGGFRAPNTNFYRAPEEYAHDEKAFGRYCADRIAEAIEFEGPDTVAAVFLEPVQNAGGCFPPPPGYFERVREICDEYDVLLVSDEVICAYGRIGSMFACNDFGYVPDIITSAKGLTSGYSPLGAMVASDRLFEPFNDGKTTFGHGYTFGGHPVSSAVALANLDIFEREGLNDHVKTMAPAFKSTLEKLYDLPIVGDVRGEGFFYGIELVKDKTTKETFNDEESERLLRGFLTPALWEAGLYCRADDRGDPVVQLAPPLISGQAEFDAIYDILHGVLSEAGKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUY5</accession>
    <name>A0A132PUY5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6 9">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 6 9">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mdh</name>
        <name evidence="13" type="ORF">AFM11_02710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 6 9"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843405.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35485"/>
    <dbReference type="EnsemblBacteria" id="KWX26161">
        <property type="protein sequence ID" value="KWX26161"/>
        <property type="gene ID" value="AFM11_02710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.556"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="PTHR23382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="12">
        <location>
            <begin position="156"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="11"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX26161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="328" mass="34287" checksum="041810C1B007DD9E" modified="2016-06-08" version="1">MTRPQVVTVTGAAGQIGYAALFRIGAGALLGRDVPVKLRLLELPSALRAVEGVVMELVDSALDLLIDIEIHDDPVRAFDGVDVALLIGARPRSKGMERADLLAANAAIFAEAGKALNAGASSDVRIVVVGNPANTNALVASAHAPDIPAERFTALTRLDHNRAVAALATHAGAHVSDVSRVTVWGNHSPTMYPDIFHAVVDGRPGAEYAADTEWLTTDFIPTVAKRGTAIIEARGTSSAASAANAAIDHVRDWVDGTDPDDWTSVALPSPGAYGIPEGVVASLPVRAVDGAWQIVEGLDVNEFSRARIDASVAELLDERAAVERLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUZ7</accession>
    <name>A0A132PUZ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26156">
        <property type="protein sequence ID" value="KWX26156"/>
        <property type="gene ID" value="AFM11_02675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.549"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="85" mass="9206" checksum="AE721310C2FCE464" modified="2016-06-08" version="1">MVFMIAPRGFRRRGFSARTSRVKWAVKWADALAEGIVGTPPNMERATSETLKRLLIAAGLVALALILAAVAVYAIAFIMLAPMMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV73</accession>
    <name>A0A132PV73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_01670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843658.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26258">
        <property type="protein sequence ID" value="KWX26258"/>
        <property type="gene ID" value="AFM11_01670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.344"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="110" mass="11793" checksum="527A397D71C4DFA5" modified="2016-06-08" version="1">MTAEAKSERLIRVCAVGELRPGGVKRVDVDPPIALYNIGGTFYATADWCTHDRSSLADEGFVENGQVECGWHFAKFCVRTGAVTAPPATQPLATYSVQVIDDAVYVTVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV94</accession>
    <name>A0A132PV94_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH asnC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_02110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34890"/>
    <dbReference type="EnsemblBacteria" id="KWX26278">
        <property type="protein sequence ID" value="KWX26278"/>
        <property type="gene ID" value="AFM11_02110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.432"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="167"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="311" mass="33924" checksum="8518CA364C731D38" modified="2016-06-08" version="1">MEMLDPLALRITEALQVNGRASWRRIAEVLDEPVRTVARRGAALLEDRTVQVVGLTALAPTHLLRVQCRPDAVQSVARALAARPDTVFVYALAESAEVIAEVTSEFDALPSLLVMDLDGVITHRLTPVLQYFRTVAEWRAGVLTPDEVAALELPDVPPEQTRTGLQVDDVDRAIIDALVADGRTPFEAIASLAGFSQATARRRIDQLIQRGFVRIRAVVGPALLGLPVEALLWIRCAPQHAEHIGTTLARSPLVRYAAMVMGEYPVVVDVTAHDTAELRDFLTTGPWEGRVESVHSTLLLQTFKRGGVVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVH0</accession>
    <name>A0A132PVH0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cutinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26274">
        <property type="protein sequence ID" value="KWX26274"/>
        <property type="gene ID" value="AFM11_02020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.413"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="244" mass="25056" checksum="D21933A83067747D" modified="2016-06-08" version="1">MFFAIGTPPASAEPCPDVEVVFARGTGEPPGVGPTGQAFVDSLRQRVGDKTLGVYPVNYPATDQWTTGVDGIRDAGAHVTRMAATCPDTKMVLGGYSQGAAVMGFVTSAAVPDGVDPATVPKPLEPDIAEHVAAVVLYGTPNLRAMNFLGEPPVIIGPEYEPKTLKVCAPEDFVCSDGLNFAAHTSYGYDGLIAQGVDFAASRLGLEPAPPAAPPAQWDQLPAPQPPPAPAPPAPPAPAPLATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAV0</accession>
    <name>A0A132PAV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000049">
        <property type="protein sequence ID" value="KWX19453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859958.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31625"/>
    <dbReference type="EnsemblBacteria" id="KWX19453">
        <property type="protein sequence ID" value="KWX19453"/>
        <property type="gene ID" value="AFM11_35785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5894"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="28131" checksum="ADAC0B186AA4A078" modified="2016-06-08" version="1">MQVENKVAVVTGGGSGIGRALAIELARNGVQVVIGDLDEHKATDAAKCIGDAAASVQADASTVDGITSLIAGAERNFGPVDLFVANAGIMGAAGLGDSGDWDKILAINLRAHINAAELLLPGWLTRGSGYFVSVASAAGLLTQLGSAGYAVTKHAAVGFAEWLAITHSEDGIGVSCVCPLGVDTPLLDAVRSSQGPSSQISARSIIKSGRVISAAEVAAETIDAIREDRFMVLPHPEVLDMFRGKGADYDGWVARMRRVQRSLRRDVTEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAW8</accession>
    <name>A0A132PAW8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Phosphatidylinositol phosphate synthase</fullName>
            <shortName evidence="10">PIP synthase</shortName>
            <ecNumber evidence="10">2.7.8.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_35725</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61216"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
            <dbReference type="ChEBI" id="CHEBI:144472"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Contains a di-nuclear catalytic Mg(2+) center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000047">
        <property type="protein sequence ID" value="KWX19469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859924.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12685"/>
    <dbReference type="EnsemblBacteria" id="KWX19469">
        <property type="protein sequence ID" value="KWX19469"/>
        <property type="gene ID" value="AFM11_35725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5881"/>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02241">
        <property type="entry name" value="PIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044268">
        <property type="entry name" value="PIP_synthase_PgsA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="10 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453132" description="Phosphatidylinositol phosphate synthase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="CDP-DAG binding" evidence="10">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX19469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="225" mass="23866" checksum="AFD1954AC41FAA64" modified="2016-06-08" version="1">MSNFYLMTRAAYVKLSRPVAKAALRAGLTPDIVTLAGTAGTVISALTLFPIGQLWWGAFAVWIFVLADMLDGAMARERGGGTRFGAVLDATCDRIADGAVFAGLLWWAAFGLDSATLVVATLICLITSQVISYIKARAEASGLRGDGGLIERPERLVIVLVGAGLSGVPFLHMPWLLHVAMWLLAVASVVTLLQRLHTVRISPGAMDPLQPASPNNGEKPETSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAZ5</accession>
    <name>A0A132PAZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_35655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000046">
        <property type="protein sequence ID" value="KWX19474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859890.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31570"/>
    <dbReference type="EnsemblBacteria" id="KWX19474">
        <property type="protein sequence ID" value="KWX19474"/>
        <property type="gene ID" value="AFM11_35655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5866"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="30328" checksum="B321648846465506" modified="2016-06-08" version="1">MLIVVVAGLVSGAVLLLATVGFELLRRVEGFLNIAHPQLIVLSGFSAYGFNVLVGLHWIVSCVLAIVVTTLVGVVTARVIFWPMRQRPHYIPMIASVGLAFFLHAMIELFTGFGVKTLDVPLQKTISVGGVAVAGADQIAVIGTAALVVVALHFWLSKSYSGRALRAMANNQALAQIRGVNTSYLQYLTWAVASALAALAGTLIALTARIYPELGWDQVLVISAAAIIGGLGSIYGVMLAAILVGLTSSLATLAIPSEYTQMVVFAAIALVVFVRPEGLFSGPKERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB11</accession>
    <name>A0A132PB11_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="3">DHNA-CoA synthase</shortName>
            <ecNumber evidence="3">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menB</name>
        <name evidence="4" type="ORF">AFM11_35530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859791.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02720"/>
    <dbReference type="EnsemblBacteria" id="KWX19500">
        <property type="protein sequence ID" value="KWX19500"/>
        <property type="gene ID" value="AFM11_35530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5841"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="147"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="304" mass="33691" checksum="420280EE290D7EA6" modified="2016-06-08" version="1">MSSNPFDPTVWEPVPGFDDLTDITYHRHIADGAKKPTVRVAFDRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRTGYQYAAGETAETVDPARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVTCDLTLASREHARFKQTDADVGSFDGGFGSAYLARQTGQKFAREIFFLGRAYDAETMYQMGAVNEVVDHADLEKAGLQWAAEINGKSPQAIRMLKFSFNLIDDGLVGQQVFAGEATRLAYMTDEAVEGRDAFLEKRDPDWSSFPRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB47</accession>
    <name>A0A132PB47_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_35330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000043">
        <property type="protein sequence ID" value="KWX19536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040733.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19536">
        <property type="protein sequence ID" value="KWX19536"/>
        <property type="gene ID" value="AFM11_35330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5797"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="437" mass="48099" checksum="D421394A450E8955" modified="2016-06-08" version="1">MLTVVHEGRDPNEAGDAAGAGRSLLDEIVRDGARQMLAAALQAEVADYIARHAGEVDDNGHRLVVRNGYHTERDVMTAAGAVTVKAPRVNDKRIDPETGQRKRFSSAILPAWARRSTQVSEVLPLLYLHGLSTSDFGPALEQFLGSGAGLSPASITRLTAQWQDEAKAFGQRDLSQVDYVYLWVDGIHLKVRLEQEKLCLLVMLGVRADGRKELVALADGYRESTECWADLLRDCRRRGMRAPVLAIGDGALGFWKALREVFPDTREQRCWFHKQSNVLAALPKSAHPGALAAMKEIIGAEDIDKAQIAIAAFEQDYGAKYPKAVKKIVDDADVLLEYFRYPAEHWVHLRTTNPIESTFATVRLRTRVTKGPGSRAAGMAMAYKLIEAAQSRWRAVNAPQLVALVRAGALFHKGKLLERPVDITPEPSPDTPVSEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB50</accession>
    <name>A0A132PB50_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000043">
        <property type="protein sequence ID" value="KWX19524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19524">
        <property type="protein sequence ID" value="KWX19524"/>
        <property type="gene ID" value="AFM11_35320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5795"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="171"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="407" mass="45896" checksum="D5B315563C8A327B" modified="2016-06-08" version="1">MYGLTLSARREITKKEAGAYVAASKKAKGEILDRLVAEVGWSRANARRQLGRAFKRRGPARMEVRKPRPPTYGYDTVKVLQQVWVVAGQPCGKYLAAVMGTTLANMDAHIRAGAFGRVRARYSPAVHDQLLAMSAATIDRLLAPFKLSMYPDGKSTTRSRRNQYTESIPIMSRIPDIDWQPGLVAIDTVAHCGNNAKGQYAFTLTATDVYTGWTSNRAIKNKAAKWVVKAMDEILDEFPYPIDHIHSDNGSEFLNDPVTTWCNAHNIRMTRSRPHHSNDNPFVEQKNEAVVRRSAFNYRYDTDAELGLLNELWPLVNLRKNLFLPTKKVTGYHLSRKGKSVRSYDDPRTPADRIKDTGIMLEPQRHYLDELYASLDLAGLTNRINEIQQRLIRLAAAKTYSQAPHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBA4</accession>
    <name>A0A132PBA4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hist_deacetyl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859619.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19609">
        <property type="protein sequence ID" value="KWX19609"/>
        <property type="gene ID" value="AFM11_35025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5734"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="33"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="363" mass="39044" checksum="ADE021EDBB44ABF3" modified="2016-06-08" version="1">MATGIWYDERCLAHDNGSMILDERAASWLRVTHAENPQRLARAVTVLEASGVARELDWFPLREAAVDDLALVHTRAHIDRVRAACDSESTVFVGPEARAGRGSWEPALLSAGGTVAAVDWVLDGVERNAYVLARPPGHHASSDTAMGFCLFNNVAIAARHAQRRHGLGRVAIVDWDVHHGNGTEDVFYEDPSVLYISLHQDGLYPPGRGLVQDRGRGAGSGTTVNIPLPAGMGDAGYLAAVDRIVVPALRSFAPDLILISAGQDPSAADPLGRMSVTAEGFRGMTRRLADVANDVCEGRLIAVQEGGYSVDHVPFCVLAIVEELAGLIPQFSSDPMELDTPQAIRDWEIEAIDSVRICDDSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBN6</accession>
    <name>A0A132PBN6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_34445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859256.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11225"/>
    <dbReference type="EnsemblBacteria" id="KWX19739">
        <property type="protein sequence ID" value="KWX19739"/>
        <property type="gene ID" value="AFM11_34445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5233"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX19739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="587" mass="61723" checksum="C832BA8B7CC15CB3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBT7</accession>
    <name>A0A132PBT7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859043.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02495"/>
    <dbReference type="EnsemblBacteria" id="KWX19776">
        <property type="protein sequence ID" value="KWX19776"/>
        <property type="gene ID" value="AFM11_34045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5146"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009758">
        <property type="entry name" value="DUF1326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014581">
        <property type="entry name" value="UCP033303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07040">
        <property type="entry name" value="DUF1326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033303">
        <property type="entry name" value="UCP033303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="216" mass="23834" checksum="0705D931621E3116" modified="2016-06-08" version="1">MTVTTTTDWSLRGEWFDVCSCKLPCPCSFAQEPTHGDCLFTLVWKIHEGHYGATNLSDLGVVAIGEFKGNMWVGDPEATMSLMFYIDDKADADQRHALEQIFTGYEGGWPGEFGSLIGELRGIEYAPITFDAAEDLAYWRAEIPGKVDVRVEALTGPTADPNKRVTTVNAPGAEVGPGQVATWGVVKKDEAVGFDFSHEYRGGSSKHFPFDWRPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBY1</accession>
    <name>A0A132PBY1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydroorotate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33785</name>
        <name evidence="2" type="ORF">AWC31_07970</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858879.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07970"/>
    <dbReference type="EnsemblBacteria" id="KWX19828">
        <property type="protein sequence ID" value="KWX19828"/>
        <property type="gene ID" value="AFM11_33785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10107">
        <property type="protein sequence ID" value="ORX10107"/>
        <property type="gene ID" value="AWC31_07970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5094"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043758">
        <property type="entry name" value="DUF5703"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18963">
        <property type="entry name" value="DUF5703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="89" mass="10125" checksum="BC6BF689E40A4405" modified="2016-06-08" version="1">MTAVQRGRMPPGWDKVVAEDLSDEYDWVPLRLPPDVTRVSASIRLSIEAEYRGWELTRVRAYTDGSRRVLLRRKKTAATMPGTPDQPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC00</accession>
    <name>A0A132PC00_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_33995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859012.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02445"/>
    <dbReference type="EnsemblBacteria" id="KWX19767">
        <property type="protein sequence ID" value="KWX19767"/>
        <property type="gene ID" value="AFM11_33995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5136"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="406" mass="41991" checksum="0E7B7B468B561F94" modified="2016-06-08" version="1">MTPVAVDGALGLKEQRTQRWAYPLLLVLSGVALGVSGVPAPLYGIYETAWHLTPLATTIVFAVYAIAALAAVLVSGRISDVIGRKPVLLFALVAMIVGLGVFLVADTMALLLVARTIHGAAVGSIVVVAAAALLDLRPHLGVRSGQLSGVAFNIGMTVAIVGSAMLAQYAPHPLRTPYAVVAVVCVIVGVGVIALRETHTTRSSGPIRISKPAVSQEIRSDFWFAALGAMASWSVLGVLLSLYPSLAAHQTHIDNLVFGGGVVGVTAFSAALIQLAATRIPAHRAAILGDVGMAITLLLTVPVLLTHSWPLVFVAAALLGATFGLGFGASLRHLSHVVPADQRGETMSAFYVLAYTAMAVPTLLAGWAATRWNLATVFPWFAAAVALACLTAAAIGARSIRAAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC70</accession>
    <name>A0A132PC70_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858797.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02320"/>
    <dbReference type="EnsemblBacteria" id="KWX19918">
        <property type="protein sequence ID" value="KWX19918"/>
        <property type="gene ID" value="AFM11_33395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5011"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="236" mass="26144" checksum="30B5683067095075" modified="2016-06-08" version="1">MATTTIPLLPCTDRDQTVEFYRALGFDTSDQQTKPYLYLAFALADINVHFKKPAPSLNPAEELSGGCVIFVDDVRGFHATFSDGLRRHYGRLPITGLPRIARLRPGQSRFNLYDPSGNCLVFIRRDEADITYGGARSLSGLARALDNVAIFRDFKDDDVLAARALDTALRRYRDSAPRVDLARALADRIELAIVLGDSATADSVRAELDSMHLTPDEREGAATELQAITDLERWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCD5</accession>
    <name>A0A132PCD5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858597.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16945"/>
    <dbReference type="EnsemblBacteria" id="KWX19964">
        <property type="protein sequence ID" value="KWX19964"/>
        <property type="gene ID" value="AFM11_33280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4988"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="30"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="385" mass="40704" checksum="D41274449C510B2D" modified="2016-06-08" version="1">MDVSLRAGIPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAGAPAPVREAAVAALNRNQLGYTVALGIPELRAAIAGSYRARYGVDVGVDDVVITTGSSGGFLLTFLACFDVGDRVAIASPGYPCYRNILTALGCEVVEIPCGPETRFQPTVTMLEELDPPVQGVIVASPANPTGTVIPPEELAAIASWCDASGVRLISDEVYHGLVYEGAPATSCAWETSRKAVVVNSFSKYFAMTGWRLGWLLVPAELRRAVDCLTGNFTICPPALAQHAAVAAFTPESLGEAEGLLAHYADNRRLLLDGLRAIGIDRLAPTDGAFYVYADVSEFTNDSLSFCSKLLADTGVAIAPGIDFDTVRGGSYVRLSFAGPTSDIEEALCRIGPWLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCE1</accession>
    <name>A0A132PCE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_32765</name>
        <name evidence="8" type="ORF">AWC31_32140</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858288.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32140"/>
    <dbReference type="EnsemblBacteria" id="KWX19986">
        <property type="protein sequence ID" value="KWX19986"/>
        <property type="gene ID" value="AFM11_32765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12605">
        <property type="protein sequence ID" value="ORX12605"/>
        <property type="gene ID" value="AWC31_32140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4882"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX12605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="470" mass="48226" checksum="4F230CE4EB970A4B" modified="2016-06-08" version="1">MNRLDRFFEISARGSTFAAEIRGGLVTFIAMAYIIVLNPVILSSAPDVDGTRLEFAQVSATTSLAAGVMTILFGIFARLPFAFAAGLGINSFLATTVVGSVTWPEAMGLVVINGLIIVLLAVTGLRRLVFDAVPMQLKLAITAGIGLFILFIGLVDAGFVGSTGLPSPPVGLGTGGVGSINTVPTVVFVFTLLVTGILVARRVRGGILIGLVAGTVVAVIIEAIWHLGSAVDKPGGWGLSVPSLSGSPFALPDLSLVGEFSMGSFGRIGALAAIMLVFTLVFANFFDAMGTMTGLSREAGLADPQGTFPRLRSALIVEGTGAVVGGASSASSNTVFIESGAGIEEGARTGFANLITGVLFLAAMFVAPLASIVPTEVAAAALVIVGAMMVSHLRHIDISEFSVALPVVLTVATMAFSYSIANGIGVGFVAWAVLRSAAGKAREVSPLLWVVAAGFVLYFARGWIESLIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDG9</accession>
    <name>A0A132PDG9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857233.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26705"/>
    <dbReference type="EnsemblBacteria" id="KWX20379">
        <property type="protein sequence ID" value="KWX20379"/>
        <property type="gene ID" value="AFM11_30995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4101"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="2">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="236" mass="25056" checksum="7EE33BDD540A88F7" modified="2016-06-08" version="1">MTQSSLTLGYVPGGTPAKWARIWAERHPEVPLQLCAVDAADAADAVRAGTVDVALMRLPADTSGLAVIPLYEETTVAVVPADHLLTAVDEITAADLDGEPTLLPLDNVVTWAAPGTPLEHRPDTTKDAIELVAAGMGVLVVPQSLARLHHRKDLTYRPITDAPTCPVALAFPEGPQSPLVEEFIGVVRGRKPSSSRGQAEPAPKRTAREKTLAKQAARAAAGKVARKPSRTQRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDL5</accession>
    <name>A0A132PDL5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_30890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857171.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26610"/>
    <dbReference type="EnsemblBacteria" id="KWX20423">
        <property type="protein sequence ID" value="KWX20423"/>
        <property type="gene ID" value="AFM11_30890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4080"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="254" mass="27975" checksum="CAED9F7EA7DACBA0" modified="2016-06-08" version="1">MHEGDASRLTRNLRVLFADVTKRFSTGTVAIDRVDLEIERGSFVAVVGPSGCGKSTLLRMAAGLERPTTGSVALDTDSVGFIFQEPTLLPWRTVRANVELSAELGTVPRSDTKRRAAEAISTVGLQQFADQLPNSLSGGMKMRVSLARALTLSPQLMLLDEPFGALDEMTRLDMQVELQRLYTQQQFTAMFVTHSVAEAVYLANRVVVMTPRPGRIAGVIDIDFPYPRTPDLRFDARFTGYVEQVSGMLHGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDQ9</accession>
    <name>A0A132PDQ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20463">
        <property type="protein sequence ID" value="KWX20463"/>
        <property type="gene ID" value="AFM11_30265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3950"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="326"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="695"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="349"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="712"/>
            <end position="719"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1053"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1297" mass="142227" checksum="796EEB93818A94A8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDX2</accession>
    <name>A0A132PDX2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_31045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857390.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26755"/>
    <dbReference type="EnsemblBacteria" id="KWX20427">
        <property type="protein sequence ID" value="KWX20427"/>
        <property type="gene ID" value="AFM11_31045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4112"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="448"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="483" mass="52665" checksum="5D4828D545CC2E2D" modified="2016-06-08" version="1">MTRVIRFNAFDMNCVAHQSPGLWRHPDDQSWRYKDITYWTELAKLLERGRFDGLFIADVLGTYDVYGASDEAAIRQAAQIPVGDPMLLVSAMALVTENLGFGITTGTGFEHPYPFARRMSTLDHLTNGRIGWNIVTGYLPAAARNMGQTDQPAHDARYDHADEYLEVLYKLWEGSWEDDAVVRDAERGVFTDPAKVHHIGHAGEHFSVPGVHLAEPSPQRTPVIYQAGSSPRGVRFAAENAEAIFTAAPTKAILRETVSTIRSELELAGRDPYSAKIFNLTTVITGETDEEAHAKHAEYLSYGDPEGALVFMSGWMGVDLARYGLDEPIGNVDSNAILSAVKAFQSASDKGGEWNVRDIAEWGEIGGMGPRIVGSGVRVADTLQEWVDETDVDGFNLAYAITPGSFADFISYVVPVLTARGAYQSGYAPGSLRNKLLGHGDRLADEHRGASYRVGGRNSTIIERPSTVPSSSASTAAQPARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE20</accession>
    <name>A0A132PE20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29755</name>
        <name evidence="6" type="ORF">AWC31_25095</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856538.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25095"/>
    <dbReference type="EnsemblBacteria" id="KWX20586">
        <property type="protein sequence ID" value="KWX20586"/>
        <property type="gene ID" value="AFM11_29755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14477">
        <property type="protein sequence ID" value="ORX14477"/>
        <property type="gene ID" value="AWC31_25095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3843"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX14477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="321" mass="33696" checksum="A2FF3809FF715E40" modified="2016-06-08" version="1">MTIPQPRSYTPQAELRDVTLRDGLQLTAKMLPTELKVEVIRELLAIGVPALEIGSMARPDLVPPLADTLDVVSALTPEELDKCWIWVATPRHVEKAAAAGARHFQYCFSASDSHNKANIGRNTETSVAAMPDAVRIASEAGGSIQLCIATAFTCPFEGLIDPRRVWAIAADPRTDGASDVVVCDTIGQAIPTQVGDLIRGLATSNAERRIVFHGHDTWGLGVANSLAAIDAGATMVDGSLGGLGGCPFAPGASGNTSSEDLLFALRPHWLTPDSLASLVRLSEKVLAEIGEPNRSKTAQGARSSATAFPWVIGGAAAESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE51</accession>
    <name>A0A132PE51_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GlcNAc-PI de-N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856597.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25215"/>
    <dbReference type="EnsemblBacteria" id="KWX20605">
        <property type="protein sequence ID" value="KWX20605"/>
        <property type="gene ID" value="AFM11_29875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3867"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="224" mass="24292" checksum="6F32C023673001BC" modified="2016-06-08" version="1">MNIQPFPTDWRTALVLVPHPDDPEYGIGAAVAKWTAEGKSVHYALASRGEAGIAGMPAEQAGPIREGEQRRSAAIVGVDDVVFWDFPDSAIRDTPELRAKIAETITAIAPDVVITIYSGPSWAPDAPNQSDHIEFSHAVAAAFDSLPAPPRWLFENGPEPTHGEVIDDYVDVAVDSLAAHKVYLEVLDPGTPVVEQARRQVDMSTPKSSELGGRIAEFILKRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE81</accession>
    <name>A0A132PE81_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856684.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25375"/>
    <dbReference type="EnsemblBacteria" id="KWX20635">
        <property type="protein sequence ID" value="KWX20635"/>
        <property type="gene ID" value="AFM11_30035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3899"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014188">
        <property type="entry name" value="Acrylyl-CoA_reductase_AcuI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF1">
        <property type="entry name" value="PTHR43677:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02823">
        <property type="entry name" value="oxido_YhdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="332" mass="33812" checksum="B2F22C09ADF86448" modified="2016-06-08" version="1">MDTFQALIARQDDDRITASVETLEESDLPPGEVTVRVLYSSVNFKDALALTPNGGVVRDYPIVPGIDLTGEVVASDSGEFKPGDLVLAHGYQIGTGHHGGYAEYARLPADQVVALGALTPREGAAIGTAGFTAAMSVQALADRGITPQDGPIVVTGATGGVGSVSVDLLAAAGYHVVASTGKADRADELRALGAADVIGRLPADPAAKPRPLGKAQWAGAVDCVGGATLADVLSTLQYGGAVAASGLTGGAALNTTVMPFILRGAALLGIDSVLMPIGPRRALWEQLGGPLKPRHLDDVTHEVDVKDVVGVLDEVRAGRYAGRAVVKVAGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-02-10" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEA6</accession>
    <name>A0A132PEA6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047328144.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20660">
        <property type="protein sequence ID" value="KWX20660"/>
        <property type="gene ID" value="AFM11_28935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3668"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024967">
        <property type="entry name" value="DNA-bd_IS481-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13011">
        <property type="entry name" value="LZ_Tnp_IS481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="135"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="323" mass="37497" checksum="5EC871A33FEFC2E7" modified="2016-06-08" version="1">MVHANASLTPRGRLRLAQAVVDQGWSLRRAAERFQCSVATAKKWADRYRDGGEAAMVDRPSRPHRSPLRLPKRRERRIVNLRFTRRWGPHRIAAYLHLPRSTVEAVLRRYRMPLLRHLDQNTGLPVRRPKPRRYEHPAPGDLVHVDVKKLGRIPDGGGHRKLGRQAGRRNRCGMGYTFLHHAVDDHSRLAYSEDLTDERKETAAGFWKRANAFFADHGITVKRVLTDNGSCYRSKNFAEALGPDITHKRTRPYRPQTNGKVERFNRTLTTEWAYAQTYRSEAERAGTYQHWLHHYNHHRPHTGIGGMTPIERLRVHNLPVKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PED9</accession>
    <name>A0A132PED9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_29265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040650.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20708">
        <property type="protein sequence ID" value="KWX20708"/>
        <property type="gene ID" value="AFM11_29265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3739"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="273" mass="29552" checksum="3FA3DC9FF7AEE5A9" modified="2016-06-08" version="1">MSSYDQYQHLTFDRPSEGVLQVTINRPDRLNAANKRLHWELGKVWLDVGTDSQTRVAVVTGAGKAFCAGGDLDMVLDQANDFSQIVETMAEARDIVYNIANCDKPIISAINGVAVGAGLAVALMADVSVIAEDAQLTDGHLRLGVGAGDHAAIVWPILCGLAKAKYYLLTADFIDGKEAERIGLVSLCRPPEEVLPTALEVAQKLAGGPQHAVRWTKRALNHWVRNAGPIFEASLALEMLNFFDVDVIEGASAIKDRRPPRFPSAANHERDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEE8</accession>
    <name>A0A132PEE8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_29235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047328217.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20703">
        <property type="protein sequence ID" value="KWX20703"/>
        <property type="gene ID" value="AFM11_29235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3732"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01782">
        <property type="entry name" value="MCEVIRFACTOR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="126"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="436" mass="45987" checksum="E001A765AA8D0870" modified="2016-06-08" version="1">MKSFSERNTPLIGAIGVAAVAAIVLAALNFQKLPFLNQANEYSAYFADAGGLHTGASVDVSGFPAGKVSSMELDGARVLVTFSVDRKIFLGDRTEAAIKTKSLLGSKVLDVISRGDGELTTTIPIERTVSPYQLPDALGDLATTISGLNTDQLSDSLATLAQTFSGTAPELRNAVQGVARFSQTLNERDAQLRNLLANARKATTVLAQRTDQIVTLVKSTNALLVELRTQSSAIDQIWNNISAVAQQLKGFIAENRQQLRPALEKLNGVLAIVDNRKERIQDAIKRLNAYALSLGEAVSSGPFFKAYLANLLPGQFVQPFVDAAFSDLGLDPATVLPSERIDPPTGQPATPALPVPYPRTGQGGEPRLTLPDAITGKPGDPRYPYREPPPAPPPGGPPPGPPAPPPPGVQNTPEPTPSPVYVPAPGEVPAQPGGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEI1</accession>
    <name>A0A132PEI1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_29990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856659.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25330"/>
    <dbReference type="EnsemblBacteria" id="KWX20627">
        <property type="protein sequence ID" value="KWX20627"/>
        <property type="gene ID" value="AFM11_29990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3890"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="149"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="257"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="414" mass="46766" checksum="4C0622FF8403F037" modified="2016-06-08" version="1">MDFALPEHLPGLLAEMDAFIEAEIKPLEREHIQYFDQRREYARTDWENGGIPRREWEDLLDEMRRRADAAGWLRYGLPARFGGRDGSNLDMAVIREHLAHKGLGLHNDLQDESSIVGNFPQVIMMDRFGTEAQKSEWVEAVLTGKRSMAFGLTEPGHGSDATWLETTAVADGDGWIINGTKRWNTGVHRATHDLIFARTSGEPGQARGITAFLVPTDAPGFHVPFYWWTFNMPTDHGEVELKDVRVPGDAVLGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVAYAGDRVVFGKPLAVNQAVQWPLVELQTEAQMVRLLVRYAAAQLDANHHMEVSDKVSMANYRANRLVCEAADRAMQVHGGIGYSRHEPFEHIYRHHRRYRITEGAEEIQMRRIAQRLFGFGKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEU6</accession>
    <name>A0A132PEU6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855617.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10130"/>
    <dbReference type="EnsemblBacteria" id="KWX20868">
        <property type="protein sequence ID" value="KWX20868"/>
        <property type="gene ID" value="AFM11_27600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3394"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="94" mass="9932" checksum="70291F48A6892CD9" modified="2016-06-08" version="1">MTKPQALNITFTARLGKVRPGDTWTCVQLPDSATIFGTRGLVKVAGTIDGRPFTGAFMALGDGTHKLPVAAAIRKAIGKSDGDDVEVHLAERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF34</accession>
    <name>A0A132PF34_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20884">
        <property type="protein sequence ID" value="KWX20884"/>
        <property type="gene ID" value="AFM11_27695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3413"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="85" mass="8977" checksum="61BEFF8B0E119BE5" modified="2016-06-08" version="1">MRVSNAFALNHLASSTACNTITGRSCRVDIDNAAGNPFRPLGDVAFGMAESEAATRGQRRRMRPAVPIMSDGDSTGGFLIPVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF65</accession>
    <name>A0A132PF65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855754.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10415"/>
    <dbReference type="EnsemblBacteria" id="KWX20914">
        <property type="protein sequence ID" value="KWX20914"/>
        <property type="gene ID" value="AFM11_27895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3453"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="571" mass="63626" checksum="1581A967A02F3BF5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFL3</accession>
    <name>A0A132PFL3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06910"/>
    <dbReference type="EnsemblBacteria" id="KWX21136">
        <property type="protein sequence ID" value="KWX21136"/>
        <property type="gene ID" value="AFM11_27065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3287"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="320" mass="33616" checksum="B5D68BD5D7E5051F" modified="2016-06-08" version="1">MLDFAVNVRAGSPPAWLTDRLAARLTDLGRYPSAADERRAVAAVASRHGRDESEVALLAGGAEGFALLPGLQPQLAALVAPSFTEPEAVLTAAGVPVHHVELAPPFTLAGAQVPDAADLVVVGNPTNPTGVLHPREHILALRRPGRIVVVDEAFADAVPGEPESLAGDALPDVLVLRSLTKTWALAGLRVGYALSAPELLARLTARRAHWPLGTLQLEAIAAANAPEAVAEADAGARRLTGLRAEMATALRALGLEVIAGAAPFVLFAVPDAELMRKHLESKGIAVRRCDTFVGLRPNYLRAAVREEWPVLVDAVTEVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFW2</accession>
    <name>A0A132PFW2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855632.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20872">
        <property type="protein sequence ID" value="KWX20872"/>
        <property type="gene ID" value="AFM11_27630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3400"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="163" mass="18490" checksum="5F8807445ACF358B" modified="2016-06-08" version="1">MSDTMKSTRTIDAPAQTVFDVLADPSTHQAIDGTGWVREPFDGKRLTEVGQIFRMAMYHDNYGGMHYEVANRVEVFSPPHAIAWLPGQGTDDANLDFGGWFWRYDLDPVDNDRTEVTLTYDWSAVPSTIREQIVFPPFDRQHLDNSLKHLAELAQSRVSAAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGF9</accession>
    <name>A0A132PGF9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24790</name>
        <name evidence="6" type="ORF">AWC31_27045</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854006.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21438">
        <property type="protein sequence ID" value="KWX21438"/>
        <property type="gene ID" value="AFM11_24790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14817">
        <property type="protein sequence ID" value="ORX14817"/>
        <property type="gene ID" value="AWC31_27045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2319"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX14817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="209" mass="23398" checksum="F815DC3ECBC3BDC5" modified="2016-06-08" version="1">MPDRQRRRYAPRLPREQRRQQLLDAALTVLDDCPLHELSMEAVAEAAGVGKPVLYTAFRTRAELVTALLTREHRHGIEQVRAALPEDLSIAGPTGAYTATVSAFLRSVLENPTRWRLILTVPDNAPRDYRAAVRNARSRVIAQAEEFAKAGSALDPRLAELDPVLLGHTMLSFAEMLGRLAVNDPERYPRERLEQYAVVAMTMFAGQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGI0</accession>
    <name>A0A132PGI0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27415</name>
        <name evidence="3" type="ORF">AWC31_07350</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855457.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07350"/>
    <dbReference type="EnsemblBacteria" id="KWX21102">
        <property type="protein sequence ID" value="KWX21102"/>
        <property type="gene ID" value="AFM11_27415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10000">
        <property type="protein sequence ID" value="ORX10000"/>
        <property type="gene ID" value="AWC31_07350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3357"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041098">
        <property type="entry name" value="Rv2175c_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18367">
        <property type="entry name" value="Rv2175c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rv2175c_C" evidence="1">
        <location>
            <begin position="66"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="134" mass="14557" checksum="7BF67AF63CC1C593" modified="2016-06-08" version="1">MSSVPAADDVLDPDEAVYDLAEVAGLLGIPVTKVHQQLRESHLVAVRRGGAVVVPKIFFDDTGHVVKALPGLLVVLHDGGYGNTEIVRWLFTPDPSLTITRDGSTDRQDNARPVDALHSHQAREVVRRAQAMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGL8</accession>
    <name>A0A132PGL8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isorenieratene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854049.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27125"/>
    <dbReference type="EnsemblBacteria" id="KWX21453">
        <property type="protein sequence ID" value="KWX21453"/>
        <property type="gene ID" value="AFM11_24870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2335"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="509" mass="55182" checksum="4E293F3911C8A6A9" modified="2016-06-08" version="1">MTDSRRVTHPAPPGASHADALTTRPRVVVVGAGIAGLTAATGLAERGIDVTVVEREPYLGGRVAGWNEPLRDGSEAAMNRGFHAFFRQYYNLRALLRRVDDDLSMLVPVEDYPLVDAQGRRDTFRGLPTVPPLNALVFALRSPTFRLRDLVRLNARAAAPLADVSVPATYDRLDHLNAEEFLRDINFPEAARHLAFEVFSRSFFAKPAELSAAELATMFHIYFLGSSEGLVFDVANANFDVALWSPLRAYLESLGVEFRTGAPVTAVDPAGRVTVETAGTTAEVAADAVVLAADVTGLKRIVAASPALGDTVWRASIERLGTAPPFVVHRLWLDRPVRNDRPAFLGTGGRPPLDNISVLGRYEHEAAEWCRRTGGSVLELHAYAAGGADEGLRERLLGRLHEIYPETASAAVVDERVLYRQDCPRFAPGDFASRPTITTPHANVVLAGDAIRIDLPVALMERAATTGWAAANAILAHFGVRGHELHTVPGEGRSAVLRRLAGQRRRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGP8</accession>
    <name>A0A132PGP8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">F420-0--gamma-glutamyl ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_26120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854685.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35775"/>
    <dbReference type="EnsemblBacteria" id="KWX21387">
        <property type="protein sequence ID" value="KWX21387"/>
        <property type="gene ID" value="AFM11_26120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3089"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043773">
        <property type="term" value="F:coenzyme F420-0 gamma-glutamyl ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01259">
        <property type="entry name" value="F420_ligase_FbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019943">
        <property type="entry name" value="F420_FbiB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023661">
        <property type="entry name" value="FbiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03553">
        <property type="entry name" value="F420_FbiB_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="11">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="F420_ligase" evidence="11">
        <location>
            <begin position="96"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="10">
        <location>
            <begin position="268"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX21387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="456" mass="48501" checksum="899C89FFF179F2BE" modified="2016-06-08" version="1">MTGEHGSAAATGEHGSADRVEILPVPDLPEFRPGDDLAGALAAAAPWLQDGDVLVVTSKVVSKCEGRIVVAPSDPEERDTLRRKLIDDEAVRVLARKGRTLITENAIGLVQAAAGVDGSNVDSTELALLPVDPDGSAAALRDGLRDRLGVTVGVVITDTMGRAWRNGQTDFAIGAAGLTVLHGYAGARDRHGNELLVTEVAVADEIAAAADLVKGKLTAIPVAVVRGLHLPDDGSTAHTLVRAGEDDLFWLGTAEAIQLGRSQAQLLRRSVRRFSAEPVPHELIEAAVGEALTAPAPHHTRPVRFVWVQDTATRTRLLDRMKDRWRADLAGDGRAPDAVERRVSRGQILYDAPELVIPFLVPDGAHSYPDEARTAAEHTMFTVAVGAAVQALLVALAVRDVGSCWIGSTIFAGDLVRAELDLPDDWEPLGAIAIGYPDEQQPPRDPVPTDGLLLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGU7</accession>
    <name>A0A132PGU7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_25385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854359.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27705"/>
    <dbReference type="EnsemblBacteria" id="KWX21565">
        <property type="protein sequence ID" value="KWX21565"/>
        <property type="gene ID" value="AFM11_25385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2439"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="108"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="459"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="855" mass="93010" checksum="B4034167E2D160B5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHJ2</accession>
    <name>A0A132PHJ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23690"/>
    <dbReference type="EnsemblBacteria" id="KWX21734">
        <property type="protein sequence ID" value="KWX21734"/>
        <property type="gene ID" value="AFM11_24435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2247"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="305"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="589" mass="64024" checksum="F27E1B062ECF6A2E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHR7</accession>
    <name>A0A132PHR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853152.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28095"/>
    <dbReference type="EnsemblBacteria" id="KWX21794">
        <property type="protein sequence ID" value="KWX21794"/>
        <property type="gene ID" value="AFM11_23370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2029"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="700" mass="74430" checksum="F5DC61CDF1FE724C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIK5</accession>
    <name>A0A132PIK5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_21990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852503.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04795"/>
    <dbReference type="EnsemblBacteria" id="KWX22166">
        <property type="protein sequence ID" value="KWX22166"/>
        <property type="gene ID" value="AFM11_21990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1746"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="273" mass="29989" checksum="300D7E6696E68C7F" modified="2016-06-08" version="1">MTTATITAPGTTVTAEAAEAITVDNLSVRFSSKRATVTALEEIDLRVADGEFVSIAGPSGCGKSTLLKVIAGLTDATSGEVRLRGNRVRGPQREIGYVFQRAALLEWRSVRRNILLQAEMRGMPRQAAARRCDYLIEMTGLTGFENALPHELSGGMQQRVSLCRALLHEPDVLLMDEPFGALDALTREKMNVELHRIWRETGTTVVLVTHSVAEAVYLANRVVVMSPRPGRIVEMLDVDLPAERDYAETMERPEFIRVANRVRDLLGSSSAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIU4</accession>
    <name>A0A132PIU4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852539.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22184">
        <property type="protein sequence ID" value="KWX22184"/>
        <property type="gene ID" value="AFM11_22085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1765"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="146" mass="15359" checksum="906DA91B383CDFEE" modified="2016-06-08" version="1">MGHIEATRELAASPDALWATVSDPQTWDKWFTVHDKWLEEPPSTLTAGARLTAKIVMLGMANKIEWTIESVDAPNSLVLAGTGMAGVKAKFAFTIDPAGTGSRFTVTGDFEGALVKGALAKAVEKDGVKQLDKSLDALDALASASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJD2</accession>
    <name>A0A132PJD2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851900.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30015"/>
    <dbReference type="EnsemblBacteria" id="KWX22458">
        <property type="protein sequence ID" value="KWX22458"/>
        <property type="gene ID" value="AFM11_20095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1355"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="45"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="468" mass="51380" checksum="1F85DFB03A1DE8C8" modified="2016-06-08" version="1">MRTVFDAEVDPALIDRALAASSLGSVWLDMPRPRHPALTRSASCDLAVIGAGYTGLWTALHAAERHPDWRIVLIDGHRVGWAASGRNGGFVDASLTHGENNGKTRWPNEIEKLDAMGRDNLDGMQADIARLGLDTEWQRTGMLTVATEPHQIDWLAQAAAAGEGAFLDREAVRAQVDSPTYQAGLFERATCALVHPAKLAIELARACADAGVHIHEHTDARSINSGGAVLRIETPQAVITARQAVLATNVFPSLLRRNSFHVVPVYDYVLATEPLTDAQLSRIGWHGRQGVGDCANQFHYYRLTMDNRIVWGGYDAVYHFGRKVKAGYEDRPTTYRKLAAHFFVTFPQLDDVTFSHRWAGAIDTNTRFCAHWGMARNGRVAYVNGFTGLGVGAARFAADVCLDLLDGTPTERTELEMVRKRPLPFPPEPLASMGIQATRWSLDRADHAAGQRNLLLRSLDALGLGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJG6</accession>
    <name>A0A132PJG6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-carbamoyl-L-amino acid amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851932.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11440"/>
    <dbReference type="EnsemblBacteria" id="KWX22488">
        <property type="protein sequence ID" value="KWX22488"/>
        <property type="gene ID" value="AFM11_20275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1389"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="414" mass="44843" checksum="B39B6B8CEA183614" modified="2016-06-08" version="1">MDANAFLTDFHHVATFGATPNNGVDRQAATAEDKLSRDWFAEFAARRGWELRVDAIGNMFALIEFVPGAPYVLIGSHLDSQPLGGRFDGAYGVIAALHAAQRVAARVGEHGAQVTYNLGVVNWFNEEGGRFAPSIMGSSVFAGLMDENEMLQVRDLTGVSVAEALDAIGYRGTDPRPDTAGYAEIHIEQGRILERENINLGAVESSWYTQKLDIEVLGEQSHTGATAMADRHDALVAASKVVLLVHDVTRKFEDEAIVSSVGRFTVEPNSPIVVARRVHLVADLRSASPEIVATARASLRSDIEAIAREHDIAINVRDFDVRDIQYFPQSGIELTEKVAADLGLTVRPICTMAGHDSVPMNRIVPTVMMFIPSVDGVSHCEREFSTDEDMVAGVDALTNVAWEMVNGSLAESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJL5</accession>
    <name>A0A132PJL5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22525">
        <property type="protein sequence ID" value="KWX22525"/>
        <property type="gene ID" value="AFM11_20500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1436"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039708">
        <property type="entry name" value="MT1774/Rv1733c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42305">
        <property type="entry name" value="PTHR42305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="197" mass="21003" checksum="DF40EF0D33D8011D" modified="2016-06-08" version="1">METFTFRLRWPWLLRALGRNPLVRPSDRVEGLVAVALILIALFAVPIACAIGTAVHDSRAQLYADEAQDRRLVPAVILEDATEEPGQAYDVATAPARWHAGGAQHEEAIDVPVDAKAGDSVDVWVKSDGSRVAAPTPTDQAAVAALLAASASWFGAVGAVWLLAAGVRLGLARRRVAGWDRELRLLLDDTGRAGSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJP1</accession>
    <name>A0A132PJP1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851968.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22523">
        <property type="protein sequence ID" value="KWX22523"/>
        <property type="gene ID" value="AFM11_20485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1431"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="97" mass="10446" checksum="D246A91EEAC26854" modified="2016-06-08" version="1">MTEPSDSNIEPRDGFTAARTQPNWLIQVAAWVGIIAGIVFVIIVVFFVGFYVAGYNTDRHSQWHHESGCIMGPGGMMGPGQPPASGTSNAPDLHHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJZ8</accession>
    <name>A0A132PJZ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_19440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851735.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15525"/>
    <dbReference type="EnsemblBacteria" id="KWX22668">
        <property type="protein sequence ID" value="KWX22668"/>
        <property type="gene ID" value="AFM11_19440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1221"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="255" mass="27343" checksum="688111324AF9E9F2" modified="2016-06-08" version="1">MAIRESQARRSEIVRLARSIGLASVEELSAQFGVTASTIRRDLSQLTAQGLIARTYGGAIPLDQQPESSLRQRALEGFDAKRAIARWAADQVQSAETILLDAGTTVGAMGPFLTDRRDLVVVAAGLTVLEALADADDVRVECIGGTLRHLSQGFIGPLAEATLQRLTFDRAFLGADAVTADLGICEAELVQTRLKEIMIERAGQVYVLAHAEKLGQRPFHAWAPIPPGTTLVTDSTAGDDQVRPFEDAGITVVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK60</accession>
    <name>A0A132PK60_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LapA_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_18875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851547.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_14965"/>
    <dbReference type="EnsemblBacteria" id="KWX22577">
        <property type="protein sequence ID" value="KWX22577"/>
        <property type="gene ID" value="AFM11_18875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1110"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010445">
        <property type="entry name" value="LapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06305">
        <property type="entry name" value="LapA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="LapA_dom" evidence="7">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="120" mass="12649" checksum="848AACDC4A82025F" modified="2016-06-08" version="1">MTSDQSASPDLPEPMPGSPLPPETGKPTKPEAQPKFTRAAALWSALIMGFLVLIVLLIFIAQNTTSAEFAFLGWHWTLPLGVAILGAAVAGGLLTVAAGTARIFQLRRAAKKNLKAALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL09</accession>
    <name>A0A132PL09_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850766.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01390"/>
    <dbReference type="EnsemblBacteria" id="KWX23031">
        <property type="protein sequence ID" value="KWX23031"/>
        <property type="gene ID" value="AFM11_16820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.717"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="PTHR10543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="494" mass="54448" checksum="2A4EA2A51143DB45" modified="2016-06-08" version="1">MTTTLSARESENLYLAGNYAPVHQETTALDLAVTGTIPDYLDGRYLRNGPNAVGDPDPARYHLFLGDGMVHGLRLRDGKAQWYRNRWVRSADVARALGERWPGGARRAGFDFAANTNVIGHAGRTLALTEAGVRPYELDDELETVGGSDFCGTLMAGYTAHPKRDPKTGELHAVSYHPMRGNLVQYTVTDVDGKVRRAVDIPLRAQTMMHDFSLTEHYVVLYDLPVALDFSGQMTTRPAKAAARWLSRFAARHAAPDFVVRAVIRGSENGGASALGAFPYRWAPERQARVGVLPRAGTAADIRWFEVNPCYVFHPLNSYDESGPEGERIVLDVVRHESVFAPEEQFTNARTLDRWTVDLTAGTVREERLDDTAQEFPRVDERRVGLRHRFGYAVGYAPQTPGITAPEAILRHDLATGASEPVSFGPGREPGEFVFVPSSPDAAENDGVLMGFVYDRASDRSDLVLLDGQTLQTVATVHIPVRVPHGFHGNWVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL27</accession>
    <name>A0A132PL27_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ketosteroid isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16925</name>
        <name evidence="4" type="ORF">AWC31_01495</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850808.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23051">
        <property type="protein sequence ID" value="KWX23051"/>
        <property type="gene ID" value="AFM11_16925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13234">
        <property type="protein sequence ID" value="ORX13234"/>
        <property type="gene ID" value="AWC31_01495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.738"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453367" evidence="1">
        <location>
            <begin position="27"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="40"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX13234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="166" mass="18362" checksum="9A28705DED938BB7" modified="2016-06-08" version="1">MLNRIRLGLAVALALMFTLPMGTAMAQPYDAVESSNLATVRAGFDAWANGTGSPYDSLAQDVTWEIVGNSVASRVYTSKADFIDNVIAPFNARMSQRLIPTIRDMYTDGDTVIVFFDAEGTARDGLPYRNTYAWFLTLREDKIVKASAFFDSIAFDDLWKRVSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL28</accession>
    <name>A0A132PL28_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxybutyrate CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850601.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19955"/>
    <dbReference type="EnsemblBacteria" id="KWX22954">
        <property type="protein sequence ID" value="KWX22954"/>
        <property type="gene ID" value="AFM11_16365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.621"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="1">
        <location>
            <begin position="272"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="430" mass="45623" checksum="45DF16D311D3B1CB" modified="2016-06-08" version="1">MPQELTPEEAAMRLESTDTLGIPLGPGQPPAFLRALGTRTDWTDLRVYGALLAVGTELFSRKGVHYLSGFYGPLERSLCDSGADIEFTPADFRRFGPLLQRRSPRVMTTVATPPDADGWCSLSLHAGGTVDELRRAGADPERMLVVEVSDGYPRTFGFGEQHRHALHVDEIDVMVHSTDAPLALPGPPPTDDDKAIARHAVGFIHSGATLQTGIGSIPSQIATLLAEGDGGDYGLHSEMFTDGCMQLHRAGKVSNSAKGQYDGVSVTTFALGSPELYEWLDGNKSVAFLPVEIVNSPEVIGANHNMMSINGALAVDIQGQVVADTIDGKQFSGIGGAEDFVAGTGLELSDRSLICLPSTFSRDGALHSRIVPQFGPGAVITTPRHHVDVIVTEYGAAELEGLSVRERGHALAAIAHPDFRDELAAAADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL69</accession>
    <name>A0A132PL69_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein S4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">tRNA synthetase RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16885</name>
        <name evidence="6" type="ORF">AWC31_01455</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850790.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01455"/>
    <dbReference type="EnsemblBacteria" id="KWX23043">
        <property type="protein sequence ID" value="KWX23043"/>
        <property type="gene ID" value="AFM11_16885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13226">
        <property type="protein sequence ID" value="ORX13226"/>
        <property type="gene ID" value="AWC31_01455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.730"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025708">
        <property type="entry name" value="HSP15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016821">
        <property type="entry name" value="HSP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX13226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="121" mass="13274" checksum="6898BDCF4A158197" modified="2016-06-08" version="1">MSSVRVDSWIWAVRITKTRSAAAAACRGGHVRVNDVAAKPAQHVSPGDEVRVRLDGRERIVEVVRPIAKRVGAAIAAECLIDRSPPPPPKEILAAVPVRDRGAGRPTKRERRELNRLRGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLA3</accession>
    <name>A0A132PLA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850971.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01970"/>
    <dbReference type="EnsemblBacteria" id="KWX23130">
        <property type="protein sequence ID" value="KWX23130"/>
        <property type="gene ID" value="AFM11_17385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.831"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="38"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="433"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="523" mass="56160" checksum="A7609B7FC9E8AF66" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLE3</accession>
    <name>A0A132PLE3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_15155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850127.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15775"/>
    <dbReference type="EnsemblBacteria" id="KWX23166">
        <property type="protein sequence ID" value="KWX23166"/>
        <property type="gene ID" value="AFM11_15155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7143"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="210"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="33175" checksum="226529DB0401129B" modified="2016-06-08" version="1">MDALAGLLDGVRARGAFVLRLRMDPPWSMRIEDDAPLTLICQTAGSAVIVGDTSGITRLEPGDVALTRGTDHYVFADDPATQPTVVIHPGQRCTTLSGESLRFEMSLGVRTWGNSASGAAQAIVCAYEGRSAVSARLLDVLPPVVVVRFTEWDSPLVGLLAAEAGQDGPGQEVYLDRMLDLLLIAVLRCWFGRDGNAPAWWLAEQDPIVGPALRLIHHNPAHPWTVANLAAAVGCSRAVFARRFTEQVGEPPIAFLTGWRLALAADLLQTSRATVASVARQVGYSTPFALSSAFKRAYGISPNEHRALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLS9</accession>
    <name>A0A132PLS9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850206.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16390"/>
    <dbReference type="EnsemblBacteria" id="KWX23204">
        <property type="protein sequence ID" value="KWX23204"/>
        <property type="gene ID" value="AFM11_15360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7187"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="461" mass="47108" checksum="7FB6E0642F971FE8" modified="2016-06-08" version="1">MRPTRWRRSTHVAVGVAVIVLVAAVVAVAALFTGHRSDAAEAVRPVPAPATASPGIVPVDISAPTPTEGGLEAALAPALADPNLGMVTGRITDADTGAELWEQGAELPMQPASVNKVLTTAAALLTLDRDARLTTTVLASDSQPGLVVLHGGGDPTLSAAPADTDTWYKGAARISDLADQIRQSGVRATTVRVDTSLYSGPTMAPGWDPADIAGGDIAPMESVMLDGGRTQPTTVESRRSTSPALDAGKALAAALRIDPETVTLLPSGLSGPSTKIAEVQSAPLIERLRQMMNDSDNVMAESIAREVADKLNRPQSFEGGVDAVLHQLEGIGIDTTGADLVDSSGLSIDDRLTAKTLDEVVNAAAGHTQPALRPLVDLLPIAGGSGTLSNRYLDTEGGKAAAGWLRAKTGSLTGTNALAGIVTDDDGRVLTFALISNNAGPTGRTAIDALAAVLRTCGCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM29</accession>
    <name>A0A132PM29_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850414.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16540"/>
    <dbReference type="EnsemblBacteria" id="KWX23304">
        <property type="protein sequence ID" value="KWX23304"/>
        <property type="gene ID" value="AFM11_15965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7318"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="105" mass="11376" checksum="A1B9EA886E2544D4" modified="2016-06-08" version="1">MPVVKINAIEVPRNAGPELEKRFAHRAHAVDNQPGFLGFQLLRPVKGEDRYFVVTQWESEEAFQAWASGPAIEAHKGQQANPVATGASLLEFEVVLDVAGPGAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM93</accession>
    <name>A0A132PM93_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="13" type="ORF">AFM11_16030</name>
        <name evidence="14" type="ORF">AWC31_16605</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16605"/>
    <dbReference type="EnsemblBacteria" id="KWX23384">
        <property type="protein sequence ID" value="KWX23384"/>
        <property type="gene ID" value="AFM11_16030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18164">
        <property type="protein sequence ID" value="ORX18164"/>
        <property type="gene ID" value="AWC31_16605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7331"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="330"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX23384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX18164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="457" mass="50004" checksum="DA755C2D24EAF0F6" modified="2016-06-08" version="1">MTGAVRDFVPLRPGHASIYLCGATVQGLPHIGHVRSGVAFDVLRRWLTANGYDVAFIRNVTDIDDKILNKAADAGRPWWEWAATYERAFTAAYEALGVLPPSAEPRATGHITQMVELIERLIDKGHAYAAGGDVYFDVLSLPDYGELSGHRIDDVHQGEGVATGKRDQRDFTLWKGAKPGEPSWPTPWGRGRPGWHTECVAMCEAYLGAEFDIHAGGMDLVFPHHENEIAQAHAAGDGFARYWLHNGWVTMGGEKMSKSLGNVLAIPAVLQRVRAAELRYYLGSAHYRSMLEFSETALQDAVKAYTGIEDFLHRVRNRVGSISVGDWTPKFAAALNDDLSVPIALAEVHAARAEGNRALDAGDHDGAMAQATAIRSMMGILGCDPLDERWESRDETSAALAAVDVLVQWALASRTEARANRDWAAADAIRDRLKEAGIEVTDTADGPQWALLDRDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMB4</accession>
    <name>A0A132PMB4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 13" type="primary">ureC</name>
        <name evidence="13" type="ORF">AFM11_15245</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7 10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="5 7 10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850159.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15865"/>
    <dbReference type="EnsemblBacteria" id="KWX23182">
        <property type="protein sequence ID" value="KWX23182"/>
        <property type="gene ID" value="AFM11_15245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7162"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="12">
        <location>
            <begin position="135"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 8 9">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="5 7">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5 6">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX23182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="571" mass="60490" checksum="2A476D6AC7CC017F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMJ9</accession>
    <name>A0A132PMJ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_14545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849861.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23494">
        <property type="protein sequence ID" value="KWX23494"/>
        <property type="gene ID" value="AFM11_14545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7018"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="99" mass="10891" checksum="C2C52E9523E4BFAB" modified="2016-06-08" version="1">MVRTKVNTRLLIVWAILTGMTLIYVWLDEAVDQNGTLKASTVVTVSAIVIALIKVRIIFREFMEVRHAPALLCRLTDGWVVLIGVCLLGSYFVGSAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMN2</accession>
    <name>A0A132PMN2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretion protein EspD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849786.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09035"/>
    <dbReference type="EnsemblBacteria" id="KWX23457">
        <property type="protein sequence ID" value="KWX23457"/>
        <property type="gene ID" value="AFM11_14320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6972"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="180" mass="19325" checksum="B60D19F10AD5F4ED" modified="2016-06-08" version="1">MGDFPPHDPDDDGDYDSLAALDFSYPDDDSDDLGLAALDTYDTVGQAGDGEYWDGIGAPGEAGNEDADLPVPLFTVTNPPGTVTVSAYLDGRVHQIDLSPKVTNMTESDLADEILVIADLAGQQARSAQYSFMLEGMREHGHDDVATRDFLTRDLNLPTPEQADTARAQVFSTRYGGDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMT7</accession>
    <name>A0A132PMT7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849015.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02935"/>
    <dbReference type="EnsemblBacteria" id="KWX23650">
        <property type="protein sequence ID" value="KWX23650"/>
        <property type="gene ID" value="AFM11_12655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6621"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="219" mass="23380" checksum="0B4E6EFA5A7201E1" modified="2016-06-08" version="1">MARQPAPVTVVLPCLDEEQSLPGVLAAIPSGYQALVVDNNSTDGTAAVARRHGAAVVSEPRPGYGSAVHAGVVAATTPIVAVLDADGSLDPGQLPALVAELDRGADLVIGRRRAVDGLRWPWHARLGTAAVCWRLRQRYHLPVHDIAPMRVARRDALLSLGVTDRRSGYPLELLVRAAQARWRVVERDVAYGPRTGGKSKVSGSIRGSLIAALDFWRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMV4</accession>
    <name>A0A132PMV4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849062.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03085"/>
    <dbReference type="EnsemblBacteria" id="KWX23666">
        <property type="protein sequence ID" value="KWX23666"/>
        <property type="gene ID" value="AFM11_12765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6644"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025323">
        <property type="entry name" value="DUF4229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14012">
        <property type="entry name" value="DUF4229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="93" mass="10396" checksum="93FC0B6BF307A145" modified="2016-06-08" version="1">MIADVLAYLVARLVLVAVLAAVIFGVGQVFIEDFPLVVALLFALVIALPLGIWLFRPLRERATASIAVFDERRRKDREQLQARLRGDEPPAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN63</accession>
    <name>A0A132PN63_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_13430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849377.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03715"/>
    <dbReference type="EnsemblBacteria" id="KWX23771">
        <property type="protein sequence ID" value="KWX23771"/>
        <property type="gene ID" value="AFM11_13430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6780"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="17"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX23771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="428" mass="45971" checksum="B0D157F13124898D" modified="2016-06-08" version="1">MLAPVLALTIFVVAFWFIATERADKVKTVLIAAGLMALLGLIPGEEVFYSEHEGIDWNVIFLLLGMMVIVGVIKQTGLFDFLAIWAAKRSRGKPFRLMVMLMLITAIASPVLDNVTIILLVAPVTLVICDRLRIAPQPYLIAEVLASNIGGAATLIGDPPNIIIGSRAGLTFNDFLVHMAPAVVIIFALFVVFTRVLFRKDLRGDDVHIYDVMALQERRAIKDTRLLVRSLVVLTAVIIGFALHSVLHVAPSIVALLGAGAMLLVTDVDVAEILPEVEWPTLVFFMGLFVMVAGLVHTGVIGVLGSVAESAFGDNWFGAATALLFGSAVFGAFVDNIPYTATMTPVVEGMVAQAPDAGTGQALWWAFALGACFSGNGTAIAASANVVAIGIAKRAGHPISFWRFTRYGIVVTLLSTALAWGYVWLRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNA6</accession>
    <name>A0A132PNA6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_13675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849470.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03920"/>
    <dbReference type="EnsemblBacteria" id="KWX23810">
        <property type="protein sequence ID" value="KWX23810"/>
        <property type="gene ID" value="AFM11_13675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6831"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="433" mass="44443" checksum="1FC18D5C0BCD68CE" modified="2016-06-08" version="1">MTLLSWKYVEARADDDFVVAPHERLDWARTIGIGAQHVVAMFGATFLVPVLTGFPPATTLLFSGVGTILFLLITGNRLPSYLGSSFSVIAPVTAAVAAEGTGSALGGLIAVGVLLILIGAVVHLVGTRWIDPVLPPVVTGAIVALIGFNLAPAAKNNFEKGPLVGLVTLVLLVATLAFFRGIIGRLAIFGAVAVGYLLALILGEVDTSAIAAAPWVGLPEFQAPTFTISVLPLFLPAVIALVAENIGHVKSVGQMTGTDMDPLIGRALAADGVATVLAGAGGGSATTTYAENIGVMAATRVYSTAAYWVAAAVAIGLSLCPKVGATISAIPPGVLGGATIVLYGLVGILGVRIWLTNHVDFAKPINQMTAAIPLIIGIADFTWQAGSLTFTGIALGSIAALLIFHGMRSLEFLGGLGRRKNSLPERVDHPGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNB7</accession>
    <name>A0A132PNB7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Poly(A) polymerase PcnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_14850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849969.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18050"/>
    <dbReference type="EnsemblBacteria" id="KWX23542">
        <property type="protein sequence ID" value="KWX23542"/>
        <property type="gene ID" value="AFM11_14850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7081"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014065">
        <property type="entry name" value="tRNA_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02692">
        <property type="entry name" value="tRNA_CCA_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HDc" evidence="4">
        <location>
            <begin position="267"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="481" mass="53381" checksum="A9F2756308628F1E" modified="2016-06-08" version="1">MPEAAPADAELLAGALVALNRRADVLRGLGAVFAAAGHELYLVGGSVRDALLGRLTDTSDLDFTTDARPEQMQKFLRPWADALWDTGIQFGTIGAGLGDDRLEITTFRADSYDQVSRNPTVEFGDNLHDDLVRRDFTVNAMAVRITPDGPGEFHDPLGGLAAARDKILDTPSAPEVSFGDDPLRMLRAARFVSQLGFGVAPRVLEALLEMAPQLERITVERVAAELDKLLLGADPVAGIDLMVQTGMGAVVLPEVGDMRMAIDEHHQHKDVYWHSLTVLRQAMDLEDEGPDLVLRWAALLHDIGKPATRKHESDGGVSFHHHEVVGAKMARKRMRALKYSKQMVDDVSQLVYLHLRFHGYGDGKWTDSAVRRYVTDAGPLLGRLHKLVRADCTTRNKRRAARLQANYDDLENRIAELAAKEDLQRVRPDLDGNEIMEILGIPPGPQIGEAWRHLKELRLERGPLTRDEAVDELLKWWNARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNC3</accession>
    <name>A0A132PNC3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="5">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="primary">psd</name>
        <name evidence="6" type="ORF">AFM11_13380</name>
        <name evidence="7" type="ORF">AWC31_03665</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="5">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849356.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03665"/>
    <dbReference type="EnsemblBacteria" id="KWX23764">
        <property type="protein sequence ID" value="KWX23764"/>
        <property type="gene ID" value="AFM11_13380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11225">
        <property type="protein sequence ID" value="ORX11225"/>
        <property type="gene ID" value="AWC31_03665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6770"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00664">
        <property type="entry name" value="PS_decarb_PSD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5034535892" description="Phosphatidylserine decarboxylase beta chain" evidence="5">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034535891" description="Phosphatidylserine decarboxylase alpha chain" evidence="5">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="5">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="5">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="5">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX11225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="232" mass="24629" checksum="0A07F9EE7A2DEFB3" modified="2016-06-08" version="1">MARRPDLQSGPERLAALVRSSIPPMHSAGLPFVGASLAVAALGRNRRWVRRAGLLAAGANAAFFRHPPRVPPTRPGVVVAPADGLVCLIQDAVPPAELGLPDTPMQRVSIFLSVLDAHVQRAPIGGEVVAVQHRPGRFHSAELEAASEDNERNSVVIRTPEGVHVIAVQIAGLVARRIVCDAHVGDKLDIGQTYGLIRYGSRLDTYLPAGSRLMVSRGQRALAGETVLAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNG4</accession>
    <name>A0A132PNG4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiol-disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12975</name>
        <name evidence="2" type="ORF">AWC31_03260</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849578.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03260"/>
    <dbReference type="EnsemblBacteria" id="KWX23870">
        <property type="protein sequence ID" value="KWX23870"/>
        <property type="gene ID" value="AFM11_12975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11312">
        <property type="protein sequence ID" value="ORX11312"/>
        <property type="gene ID" value="AWC31_03260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6687"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="84" mass="9083" checksum="6A17C85B4C973A1F" modified="2016-06-08" version="1">MTLLTRAGCSLCARAAEQLAALRDELGFELVTTDVDVEAAAGDPALRAEFGDLLPVILLNGTQHSYWEVDEQQLRSDLADGIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNM0</accession>
    <name>A0A132PNM0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Allophanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_11210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848103.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30685"/>
    <dbReference type="EnsemblBacteria" id="KWX23938">
        <property type="protein sequence ID" value="KWX23938"/>
        <property type="gene ID" value="AFM11_11210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6319"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="224" mass="23862" checksum="D57E1D203586BD70" modified="2016-06-08" version="1">MSVASDLMDARGAETGPGTPHDYGDQALLLEFASTAEVLAWTDTLREAGLPGVMDIVPASRTILIKLDGHRYQAPTRQRLSKLQLQPDALAGPPAGDRVDITIDVVYDGADLHDVAELTGLTPAQVIAAHTGSPWRVGFSGFAPGFAYLVDGDERLRVPRRAEPRTNVPAGAVGLAGEFSGIYPRKSPGGWQLIGHTDAVLFDVNRDSPALLTPGMWVQFRAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNQ7</accession>
    <name>A0A132PNQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848226.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30470"/>
    <dbReference type="EnsemblBacteria" id="KWX23976">
        <property type="protein sequence ID" value="KWX23976"/>
        <property type="gene ID" value="AFM11_11430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6362"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017816">
        <property type="entry name" value="MycoS_dep_FDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03451">
        <property type="entry name" value="mycoS_dep_FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="190"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="362" mass="38142" checksum="F2CD2A5B99F4EA11" modified="2016-06-08" version="1">MPQTVRGVISRSKKQPVELVDIVIPDPGPGEVVVDIIACGVCHTDLTYRDGGINDEYPFLLGHEAAGTVEAVGEGVTHVEPGDFVVLNWRAVCGECRACKRGRPHLCFDTHNAAQKMTLTDGTELTPALGIGAFADKTLVHEGQCTKVDADADPAVAGLLGCGVMAGIGAAINTGAVNRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDLDDRKLEWAREFGATDTVNAAHADVVKSIQDLTDGHGADVVIDSVGRPATYEQAFYARDLAGTVVLVGVPTPDMTLEMPLVDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQGRLPLEKFVSERIGLDAIEDAFHKMHAGEVLRSVVVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNR1</accession>
    <name>A0A132PNR1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849117.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23682">
        <property type="protein sequence ID" value="KWX23682"/>
        <property type="gene ID" value="AFM11_12885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6669"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="259" mass="26558" checksum="3299154BE1D40DFF" modified="2016-06-08" version="1">MDTIANTTTASQFLPLAGRRALVTGGSRGIGAAIVRRLAADGAAVAFTYHSSAEQAENLAAEASASGATVIALQADNGDVDAITSALDQAADGFGGLDILVNNAGIAYGAPIDQFPLDEFDRLVAVNVRGVFAAIQAAVPHFATDARIITIGSVNADRVPVPGLSVYSMTKAAVAGLTRGLARELGPRGITVNNIQPGPTATDMNPDDDGEFADHMRNLTAVGRYGRPRDIASAVAYLASPESGFITGVTWNVDGGYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNY2</accession>
    <name>A0A132PNY2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848454.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24048">
        <property type="protein sequence ID" value="KWX24048"/>
        <property type="gene ID" value="AFM11_11840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6447"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="353"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="551" mass="59060" checksum="D25B092621D42A40" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-02-10" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPF6</accession>
    <name>A0A132PPF6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_11120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848053.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23922">
        <property type="protein sequence ID" value="KWX23922"/>
        <property type="gene ID" value="AFM11_11120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6301"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="412" mass="43970" checksum="FDFA6504D06DD9CE" modified="2016-06-08" version="1">MGIIRRLKRTSLTTWVFVALFLGALAGATLRERMVPLGVVGDVWLKLIKLIIVPLMLAVMIRSITSQKSGAAFGRTVGLAFGFYVFTTAIAALIGSTLAILLAPGQGFDYQSSESIEPPVEFSIAGFFSDLVSDNMFNSFAEGNLLQIVVIATLLGFAIRRIPDSAAVEQIAKGLDILTQIVFAYVRMVIAISPIGVFFLMASTIGKYGSAIIGSFSQLIGVFYLGVLLQIFFVYGLAVWAVARVNPLSFLRRSTPLWMFTLSTASSAAAIPVNLRVAKEGFGVSDRVRNFVIPLATEFNHDGNAILLPSMVVFASQAAGIHLSFEHLLQIVLLGTVLSFGGGGVPGGGIVKVLAVLQTFGLPLEIGAIAAGLYRLFDMGITSANCLGDLAGAIVIDRMLRRKSTEPVDARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPG5</accession>
    <name>A0A132PPG5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_09565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847182.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05660"/>
    <dbReference type="EnsemblBacteria" id="KWX24236">
        <property type="protein sequence ID" value="KWX24236"/>
        <property type="gene ID" value="AFM11_09565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5950"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="409"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="790"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="849"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="890"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1002" mass="108595" checksum="BBE47F03383E86E0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPJ8</accession>
    <name>A0A132PPJ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrodipicolinate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848176.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30560"/>
    <dbReference type="EnsemblBacteria" id="KWX23962">
        <property type="protein sequence ID" value="KWX23962"/>
        <property type="gene ID" value="AFM11_11335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6344"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="143"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="359" mass="38200" checksum="B27E76AFDA859130" modified="2016-06-08" version="1">MRRIAVWGTGNMGATAIRSAVAFPGLELAAVITSSQDKVGRDAATFARLDQATGVTATDDIDAALAECDAVAYMSSGDIRPEEAIAEIARCLRSGKHVVTPSLYSLYDPASAPPEWVERLTDAAVAGNAALLVSGVDPGWANDALAVTAAGLCTRIRSIRCQEIFDYSTYNQPHAVRVLCGFGGSMDDVPMMLLPSIPNMVWGGNVRLIGRGLGMEIDDITEKVERLPLDESVDNVLGRFEKGTQGAFRVQVIGWSQGVERVVVDHITRIDPACAPEWPQPDQGVGDHRVIIDGDPQLSIVVRADVPGGTRADGGNTTAANRLLGAIDWLATQKPGIYDGLDVPLHPPLPAEVEATRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPK6</accession>
    <name>A0A132PPK6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847278.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05460"/>
    <dbReference type="EnsemblBacteria" id="KWX24270">
        <property type="protein sequence ID" value="KWX24270"/>
        <property type="gene ID" value="AFM11_09765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5991"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="30632" checksum="2E48363DB7D0FD2F" modified="2016-06-08" version="1">MSNAVCTNYAQITAVRAGDPDAVARAWQQRTTRPTVRGDGRLMIVAADHPARGALAVGSRPTAMNSRTDLLDRLCTALADPGVDGVLATADILDDLLLLGALDDKVVISSFNRGGLAGSAFELDDRMTGATAASTAAARMNGGKMLCRIDLEDPGTVSTLAACAQAVDELAAHGLMAMVEPFLSRRVNGKVRNDLTADAVIKSIHIGQGLGSTSAYTWMKLPVVEEMDRVMDATTLPTLLLGGDPTDPDEAFASWEKALALPSVRGLIVGRTLLYPADDDVSSAVSTAVGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPP2</accession>
    <name>A0A132PPP2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847375.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05275"/>
    <dbReference type="EnsemblBacteria" id="KWX24301">
        <property type="protein sequence ID" value="KWX24301"/>
        <property type="gene ID" value="AFM11_09950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6026"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="148" mass="16188" checksum="D1E6D79AACBE358C" modified="2016-06-08" version="1">MTPEQMLDVAVEEARKGLAEGGIPIGAALFTTDGVLLGSGRNRRVQNDDPSVHGETDAFRNAGRQRDYRSTVMVTTLSPCWYCSGLVRQFNIGAVVIGEAKTFSGGHDWLAENGVKITLLEDQRCVSMMEEFIAARPELWNEDIGVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPZ0</accession>
    <name>A0A132PPZ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847715.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19135"/>
    <dbReference type="EnsemblBacteria" id="KWX24408">
        <property type="protein sequence ID" value="KWX24408"/>
        <property type="gene ID" value="AFM11_10620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6164"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="20"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="380" mass="44167" checksum="CF295053C59C33CE" modified="2016-06-08" version="1">MTITANPRVPASERIAVRCVDSDVHPMPKRGELLEYIPEPWRSKYFRSHPVGEQIYYDAPDYAHAYAMRVDAFPPDGEFACSDPDMALRQLVMEAGSDIAILEPTHSEARLGEATAAYCTAINQWLANHWLDSHNNWHERWRGSICVAIEEPHTAVAEIEKWAEHPYMAQVLMKAEPRPSWGDPKYDPIWAAATKHDITVSCHLSRGEYETLPIPPVGLPSYNHDFMVTYSLLAANQVMSLIFDGVFDRFPTLRIVFVEHAFTWILPLMWRMDAIYEARKSWMDIKRKPSEYVKDHIKFTTQPLDYPEDKTELSRAFEWMECEKILLYSSDYPHWTFDDPRWLVKHLPDHAREAIMFRNGIETYKLPETVPVLEGQVRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ64</accession>
    <name>A0A132PQ64_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Citrate lyase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_10225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847524.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18670"/>
    <dbReference type="EnsemblBacteria" id="KWX24347">
        <property type="protein sequence ID" value="KWX24347"/>
        <property type="gene ID" value="AFM11_10225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6083"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="11"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="272" mass="29378" checksum="B667A3CF4FDC9FAE" modified="2016-06-08" version="1">MALANTGPGWLFCPADRPERFEKAAAAADVVILDLEDGVAAKDREAARQALLETRLDPSRTVVRVNPTTTPDHELDLKAVAATDYTTVMLAKSEHPDQVRALAPLDVVVLIETPLAALDVVSLVQPDNAFAVMWGAEDLFAVTGGTANRRDDGSYRDVAQHVRSQTLLAAKAYGRMALDSVYLDIKDLDGLRAEADDAVAVGFDAKVAIHPTQVSVIRAAYEPTAEQAEWARHVLAEARVQRGVFQFGGIMVDAPVLRRAERIVQLAPHPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ67</accession>
    <name>A0A132PQ67_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847036.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24192">
        <property type="protein sequence ID" value="KWX24192"/>
        <property type="gene ID" value="AFM11_09320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5901"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="186"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="330" mass="35717" checksum="C6E7EA17DC00D1E5" modified="2016-06-08" version="1">MTLTGHAVVVDRWSVAQATPRHHPLIADFLATTPGLGGRKFAADSRDVAEQLDGVYPGSAVVLYGDSDDVLGYAALHQPDGEEPEVLADFVFGPSAPRDGVDAIVGDTVARFHRVATPGSYLRVYIGADQAAAIAALVDQGAWRERQFISTRKSLTDEDPSALAAAHIDGVAVLSWPEVIAGGFGEQVRQLQFDTFSEHFGNMTKTPQRWEHHLHSRAFSPDFSLAAIDRDEVVIGYVLGSVYTVGTGAAAQRSAHTDYIGVRRDRRQRGTGELLLRKIWLAALRRGFTAASLGTDIDNASKAHLLYRRLGYVAVADEYAYRIDAGGSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQE4</accession>
    <name>A0A132PQE4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFM11_07505</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845978.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22005"/>
    <dbReference type="EnsemblBacteria" id="KWX24525">
        <property type="protein sequence ID" value="KWX24525"/>
        <property type="gene ID" value="AFM11_07505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5349"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="4"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="354"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KWX24525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="478" mass="49032" checksum="9AE8D6EB82A87490" modified="2016-06-08" version="1">MREFDLLVIGGGPGGYVAAIRAAQHGLSVGLVEKERPGGVCLNWGCIPTKAMLRSAEVLQTVRDAAEYGIRADNVGFDYAAVRGRMTEVVTGLTDGVAGLLKANGVTVIEGHARFTSATTVDIYDVAATDGPRYAATPGQLVDAATARDVIIATGSTPIPLPIPGADLPGVITSDGAFGLASVPERVVIVGGSAVGAEWASLFAAFGSTVTLVEMRSTLVPAEDAEIGAALGRSFKQRGITVLTESTVTSIAQADALRVTVDGPKVAEIDADVVLFGVGRKPNTADLGLDAAGVAVDARGFIAVDEKLRTNIEHVYAIGDVTGKALLAHVASHQGLTAADVLAGHDKQIDYNVVPAATFTHPEIASVGLTEDAAKAAGHDPVTAKFPFAALGRARTFGDTEGFVKIIAGRKYGEVLGVHIIGPSASDLITEGALAITLEATLDELADTIHAHPTLGEIGMEAALAALGLPVHITPPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQF1</accession>
    <name>A0A132PQF1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_07685</name>
        <name evidence="7" type="ORF">AWC31_22180</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846072.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22180"/>
    <dbReference type="EnsemblBacteria" id="KWX24558">
        <property type="protein sequence ID" value="KWX24558"/>
        <property type="gene ID" value="AFM11_07685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16719">
        <property type="protein sequence ID" value="ORX16719"/>
        <property type="gene ID" value="AWC31_22180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5386"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX16719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="244" mass="26143" checksum="5E5B1274A16150B2" modified="2016-06-08" version="1">MIGVTRDGNVLTLELQRAERRNALNCELVDSLREAVENAANEDVRAIVLTGQGPVFSSGADLTDAAGMAEKLPDKALALNLAIDKTPVPVIGAINGPAIGAGVILAMICDLRVVAPDAYFQFPVAKYGLALDNWSIRRLTSLVGYGRARGMLLAAERLTSDVALQTGMANRIGTLADAQKWAAEIAGFAPLALQHAKRVLNDDGAYEEQWPAHKELFDKAWASKDVIEAQVARIEKRPPNFTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQU5</accession>
    <name>A0A132PQU5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24709">
        <property type="protein sequence ID" value="KWX24709"/>
        <property type="gene ID" value="AFM11_08560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5561"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="32" mass="3692" checksum="CEBAD7A24ACE008F" modified="2016-06-08" version="1">MVLFFEILLVAAVVVITWFALYAVYRLVTDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR22</accession>
    <name>A0A132PR22_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08845</name>
        <name evidence="4" type="ORF">AWC31_13525</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846645.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13525"/>
    <dbReference type="EnsemblBacteria" id="KWX24755">
        <property type="protein sequence ID" value="KWX24755"/>
        <property type="gene ID" value="AFM11_08845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18335">
        <property type="protein sequence ID" value="ORX18335"/>
        <property type="gene ID" value="AWC31_13525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5617"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="452" mass="51876" checksum="372318744532FD2E" modified="2016-06-08" version="1">MTITKEVQRVSGGEDEHGHLEEFRTDPIGLMKRVREECGDAGWFQLADKQVVLLSGAEANEFFFRSTDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEQMKGHAATIENEVRRMTENWGDSGEIDLLEFFAELTIYTSTACLIGLKFRNQLDSRFANYYHLLERGTDPLCYVDPYLPIESFRVRDEARANLVELVQEVMNGRIANPPKDKSDRDLLDVLVSIKDEEGNPRFSANEVTGMFISLMFAGHHTSSGTSSWTMIELLRHPEYYAKVQQELDDLYADGQEVSFHALRQIPHLDNALKETLRLHPPLIILMRVAQDEFEVEGFPIHKGQMVAASPAISNRIPEDFPDPDAFDPDRYVKPRQEDLINRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYEFEMSQPPESYRNDHSKMVVQLARPAKVRYRRRVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRX9</accession>
    <name>A0A132PRX9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_06660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25096">
        <property type="protein sequence ID" value="KWX25096"/>
        <property type="gene ID" value="AFM11_06660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4530"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="186" mass="18921" checksum="D9C08D4DC86724AC" modified="2016-06-08" version="1">MAAPLLAGASGVTCWIADHATATPPRPVDLSTTSNVLDSVLAAELHGAQAAMGCAAEDILVAALGRTVARVIGDGILVIDVDTHDGPSRRVAVPCVSQRGLSGSELLATARSATTGTAPIGAAVRIGYGEGVFAEPGEYLLELRVHPGPAGGLTVGWSFDVRSFDAYTVEELAEQFPSALIEVTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS52</accession>
    <name>A0A132PS52_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_06965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845517.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28685"/>
    <dbReference type="EnsemblBacteria" id="KWX25153">
        <property type="protein sequence ID" value="KWX25153"/>
        <property type="gene ID" value="AFM11_06965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4592"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="7">
        <location>
            <begin position="64"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="138" mass="14130" checksum="0171E4AA053C8AA4" modified="2016-06-08" version="1">MTDPTQPGGTADGASSPPPYPPPAGYPPPPPPGYQPPPAGYAPGFGDPIAPYGRHPVTGEPYSDKSKVTAGVLQLIGLIGFVGFGRIYLGETGLGIAQLLVGLVTCGIGAFIWGIVDAILILTDKVRDPQGRPLRDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS74</accession>
    <name>A0A132PS74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxamine 5-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_07245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845688.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17470"/>
    <dbReference type="EnsemblBacteria" id="KWX25201">
        <property type="protein sequence ID" value="KWX25201"/>
        <property type="gene ID" value="AFM11_07245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4649"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="3">
        <location>
            <begin position="48"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="243" mass="26668" checksum="441B43CA27FF8B75" modified="2016-06-08" version="1">MTSAPSPSRYGSIAFTAPVAKRQEAAGSISTYGRFRADGDDIGSVDGLDPRTRALVVAARSFFIATVTPDGWPYVQHRGGPPGFVRVLDSATIAFADYVGNEQFVTIGNLDADNRTALFFIDYPTRLRVKVFGRATVFERADSPEFVDGLLAVDDRQARGHRAIVIRVEATDVNCRRNIPPLYDEASVRERLRLARADLLDEIRVLKLRNRELEDQATAVAGSSDRPGSILSEASPARAEERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSE5</accession>
    <name>A0A132PSE5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">AFM11_05955</name>
        <name evidence="18" type="ORF">AWC31_29705</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845808.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29705"/>
    <dbReference type="EnsemblBacteria" id="KWX25243">
        <property type="protein sequence ID" value="KWX25243"/>
        <property type="gene ID" value="AFM11_05955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13972">
        <property type="protein sequence ID" value="ORX13972"/>
        <property type="gene ID" value="AWC31_29705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4383"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="126"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="249"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KWX25243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX13972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="399" mass="42706" checksum="31978CF522AC9DF9" modified="2016-06-08" version="1">MSKGRLFTSESVTEGHPDKICDAISDSVLDALLEQDPKSRVAVETLVTTGQVHVAGEVTTSAYADIPKIVRDRILEIGYDSSTKGFDGASCGVNIAIGAQSPDIAQGVDTAHETRVEGKADPLDLQGAGDQGLMFGYAIGDTPELMPLPIALAHRLARRLTEVRKNGVLDYLRPDGKTQVTIQYDGRTPVRLDTVVLSTQHADGIDLEATLTPDIREKVVNTVLADLGHESLDTSDYRLLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGSETVDPARIEKAISSVFDLRPGAIIRDLDLLRPIYAQTAAYGHFGRTDIELPWEQTNKVDELKASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSP7</accession>
    <name>A0A132PSP7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ORF">AFM11_03655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844126.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21500"/>
    <dbReference type="EnsemblBacteria" id="KWX25381">
        <property type="protein sequence ID" value="KWX25381"/>
        <property type="gene ID" value="AFM11_03655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2606"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="520" mass="55172" checksum="82381BF90EB6BA7A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSX8</accession>
    <name>A0A132PSX8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_04010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844319.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21145"/>
    <dbReference type="EnsemblBacteria" id="KWX25433">
        <property type="protein sequence ID" value="KWX25433"/>
        <property type="gene ID" value="AFM11_04010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2680"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="13">
        <location>
            <begin position="115"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="14">
        <location>
            <begin position="323"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX25433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="516" mass="57188" checksum="4575268E7608CDAC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSY3</accession>
    <name>A0A132PSY3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_03835</name>
        <name evidence="12" type="ORF">AWC31_21330</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844221.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21330"/>
    <dbReference type="EnsemblBacteria" id="KWX25405">
        <property type="protein sequence ID" value="KWX25405"/>
        <property type="gene ID" value="AFM11_03835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16572">
        <property type="protein sequence ID" value="ORX16572"/>
        <property type="gene ID" value="AWC31_21330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2643"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="248"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX25405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX16572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="491" mass="52675" checksum="AC1BFF5602F6C3EC" modified="2016-06-08" version="1">MALNSNFWRPTTALPNTSSLSLRWRVMMLAMSMVAMVVVLMAVAVYAVVSRALYDDLDNQLHSRARLLIESGSLAADPGKAIEGTAYSDVNAMLVIPGRSIYTANQQGQMLPLGQPEKDVISGELLMSLRTANHQRVLAVHLANGSSLLISKSLAPTGQVLRRLGTVLLIVGGIGVAVAAMAGGAVARAGLRPVGRLTEAAERVARTDDLRPIPVVGSDELARLTEAFNLMLRALAESRERQGRLVSDAGHELRTPLTSLRTNVELLMAAQEPGAPRLPEEEMAGLRADVIAQIEELSTLVGDLVDLTRDDAGGITPEPVDMTDVVDRSLERVRRRRNDIEFDVDVIGWQVFGDGPGLGRAVLNLLDNAAKWSPPNGRVGVRLYQIDPVHAELVVSDHGPGIPPQERRLVFERFYRSAAARAMPGSGLGLAIVQQVVLKHGGALRIDETVPGGNPPGTSIHMMLPGRPIPAGGTTHDHSDHDEDTVGAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTC0</accession>
    <name>A0A132PTC0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_04975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844694.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25589">
        <property type="protein sequence ID" value="KWX25589"/>
        <property type="gene ID" value="AFM11_04975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2876"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="DUF1537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SBD_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="NBD_C" evidence="8">
        <location>
            <begin position="273"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="427" mass="44461" checksum="9FD9BE57C892A640" modified="2016-06-08" version="1">MVLAAFVADDFTGATDALWQFQRYGLRARLLTSAAELAQENLDADYDVIGIATTARSTTGTGAARVALPALRALAGLKPELLQYKVCSTFDSSPERGNIGSVIAGVGDELGLLWPAPVLPAQPEFGRWTVFANHFASYAGKNYRLDRHEPMRRHPATPVDEADLRLHLGRQLAGEIGVLHVPLLADDTELSVALDERMHSAETAFIVDAVTDTDLARFGVSLRDLQARVGHPLFAVGSGGLSYGYAAALAGSGSRVAPAPAHADVAPPQGPVLAVSGSCSPVTDRQIRTAEDAGWFSAHIDEAGVSERARAALQQGRHSVVYTARGAGTGAAAADLSRRLGTLALGAVGDGLTSRLLVAGGDTSGDIIGMAGVTAIEISSSIDVAGLLCRSFGRNSVLDNAEVVLKGGQVGSDDFFLRVAGQAGMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTL6</accession>
    <name>A0A132PTL6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ispE</name>
        <name evidence="11" type="ORF">AFM11_04065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844895.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21090"/>
    <dbReference type="EnsemblBacteria" id="KWX25689">
        <property type="protein sequence ID" value="KWX25689"/>
        <property type="gene ID" value="AFM11_04065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2691"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="103"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="10">
        <location>
            <begin position="222"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX25689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="322" mass="33045" checksum="71C1F788FED106EC" modified="2016-06-08" version="1">MSASDGSTASEWVPTGSVTVRVPGKVNLYLAVGDLRDDGYHDLTTVFHAVSLLDEVTVRNADVLSLTLSGEGVESLPTDERNLAWRAAVLMAEHVGRAPDVAISIEKSIPVAGGMAGGSADAAAVLVAMNTLWELGVPRRDLHALAAQLGSDVPFALHGGTALGSGRGEELATVLARNTFHWVLAFAHRGLSTPKVFGELDRLRADERRGELPRAEEPEPVLAALASGDPAELAALLGNDLQPAALSLYPDLRRTLRAGVEAGALAGIVSGSGPTCAFLCPSSTAAVDVGAQLAGAGVCRTVRVASGPVHGARVVPAPSPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU40</accession>
    <name>A0A132PU40_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_00755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842405.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33795"/>
    <dbReference type="EnsemblBacteria" id="KWX25856">
        <property type="protein sequence ID" value="KWX25856"/>
        <property type="gene ID" value="AFM11_00755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.155"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="22196" checksum="AE094A7DB1E07A04" modified="2016-06-08" version="1">MTARELKIPGAWEITPKLHGDSRGLFFEWFTDSGFHAFAGHRFDMRQANCSVSAAGVLRGVHFSELPPSQAKYVTCLRGAVFDVVVDIRVGSPTFGQWDSVLLDDRDRRSIYLSEGLGHAFLALEDDSTVMYLCSTPYAPQREHTIRATELGIDWPDTHELVLSERDANAPTLDEVRAAGLLPTWDDTRAFVEELRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUA2</accession>
    <name>A0A132PUA2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_01130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842610.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34170"/>
    <dbReference type="EnsemblBacteria" id="KWX25921">
        <property type="protein sequence ID" value="KWX25921"/>
        <property type="gene ID" value="AFM11_01130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.232"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="226"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="313" mass="34066" checksum="17C2BC49A666464A" modified="2016-06-08" version="1">MTEGIGVAVRQLRWEADGVVSVQLHPSAGGLLPPWSPGAHIDLVLPTGIRRQYSLCGPVGERSYYRIGVRRERASRGGSEYVHAFLRPGQRLMIAGPRNTFELRRADSYVFVAGGIGITPIIPMIRQAESWGLDWKLLYGGHTVTSMPFLDELRAHGSRVSFFPSDADGRIPLAEHFAQVRAEVKIYACGPATMLAALEDAVAHWPPGSLQLERFKPRSRPSTPDRPVEVVCAASGKTVTVSEDQSILTALEAGGVNVPSSCRSGICGACETRVLEGVPDHRDDILSETERAANDRMYVCVSRAQTPQLVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUB9</accession>
    <name>A0A132PUB9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cholesterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_01250</name>
        <name evidence="10" type="ORF">AWC31_34285</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842663.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34285"/>
    <dbReference type="EnsemblBacteria" id="KWX25938">
        <property type="protein sequence ID" value="KWX25938"/>
        <property type="gene ID" value="AFM11_01250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11737">
        <property type="protein sequence ID" value="ORX11737"/>
        <property type="gene ID" value="AWC31_34285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.256"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="7">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="6">
        <location>
            <begin position="190"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="8">
        <location>
            <begin position="468"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX11737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="578" mass="62834" checksum="7E94F41ED2653C61" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUG1</accession>
    <name>A0A132PUG1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodiol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842824.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25981">
        <property type="protein sequence ID" value="KWX25981"/>
        <property type="gene ID" value="AFM11_01550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.317"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="85" mass="9490" checksum="F4A6AEBD74BE7895" modified="2016-06-08" version="1">MTTRLSNEFADVVLEVVSTGNGERLQITSPRRGTSIRLDPVELEALTWQTTDTFTRMLEGSIGPSRTEFGVAEPDFVRSDERTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUL3</accession>
    <name>A0A132PUL3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_01790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842919.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34570"/>
    <dbReference type="EnsemblBacteria" id="KWX26010">
        <property type="protein sequence ID" value="KWX26010"/>
        <property type="gene ID" value="AFM11_01790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.368"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="716"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="861"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="250"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="339"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX26010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="888" mass="94248" checksum="1610D8AB9EB5A3E3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUL7</accession>
    <name>A0A132PUL7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842976.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34690"/>
    <dbReference type="EnsemblBacteria" id="KWX26026">
        <property type="protein sequence ID" value="KWX26026"/>
        <property type="gene ID" value="AFM11_01900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.390"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="12"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="282" mass="28920" checksum="8CFFF33D7672AC8B" modified="2016-06-08" version="1">MTLATTWSTAMGLDVPIVNAPMGGAAGGRLAAAVSAAGGLGMIGMGSAATPDQLRRELAILQGLDRPFGIGLVHWVMVDRPELFEIALAAQPTLLSVSFGDDWDWVRHAHDAGVKVATQVPTVDAARRAADAGVDVLVARGAEGGGHGEPTVGTLPLLAEVLDAVELPVLAAGGITSPRSVAAVLAAGAAAAWLGTVFTTCAEALTPDAARDALLAGTETELTREFDVAAGYRWPPTIPERVLRGSSVNAGQGVGMVNQALPAAQTIERLCWGAEALLRRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUT4</accession>
    <name>A0A132PUT4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843141.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35000"/>
    <dbReference type="EnsemblBacteria" id="KWX26080">
        <property type="protein sequence ID" value="KWX26080"/>
        <property type="gene ID" value="AFM11_02220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.454"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="315" mass="35135" checksum="ED46F7DB99687D09" modified="2016-06-08" version="1">MTDTPDDELSAATAAVREAESLRRRLDAAKVAAKESAERAQAAQRQVAAEARDVAKLESFSLTMILSHLKGSHDDAMARETAEHQAAEYEYRTQQARADADQRLVDHLTRQLQALGDVTSRYEQALAAKERWLHDHHDPTSVRLLKIAERRGQLTASHTELDQAYEAGQQALGDLRTAAERLDSARSWSAYDTWFDGGMIASIVKENRLDDVAVLLRSADGALRRFTTELADVHMAGVQAVELSSFTRVFDVWFDNFFTDLIVRDRIIEAQENVEKAITGVKRVLDNLRVAKQSVADELTALRAGRAALLTSHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUV4</accession>
    <name>A0A132PUV4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02555</name>
        <name evidence="3" type="ORF">AWC31_35330</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843328.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35330"/>
    <dbReference type="EnsemblBacteria" id="KWX26138">
        <property type="protein sequence ID" value="KWX26138"/>
        <property type="gene ID" value="AFM11_02555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11915">
        <property type="protein sequence ID" value="ORX11915"/>
        <property type="gene ID" value="AWC31_35330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.524"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="68" mass="7683" checksum="9DE4150359F30569" modified="2016-06-08" version="1">MDREDLPDEVPVADAVEQQRETTGPVEDEEAFTPSADAPPLEATEPDWQEQREAVDLDPELDEFGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUW3</accession>
    <name>A0A132PUW3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843243.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35175"/>
    <dbReference type="EnsemblBacteria" id="KWX26110">
        <property type="protein sequence ID" value="KWX26110"/>
        <property type="gene ID" value="AFM11_02395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.491"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453608" description="NMT1 domain-containing protein" evidence="1">
        <location>
            <begin position="40"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="55"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="350" mass="37041" checksum="E556C8F623CA278D" modified="2016-06-08" version="1">MSKHLDRRQFITRGLAFGGLALTGPAVLSACVTGESSGAADGFGVASQRLAWIKNTQFAGSYIADKKGYYRDAGFSGAELVSGGPTAPPIESDVLSRTFAGVSQVPIVGSAVAKGAPLKIVGAVYSRYAGCIMTMADKPVNTPEDLYGKTIGCASSSEPVWRNFLAALKLDESKINTVPVQGDPIGMTVGEIDGYLGFINSQVVDLRHKGFDISTMLLADVGFPLVGQTYITTQDNIDNNRDKLKAFLHAEIRGWREVLGDPQMATDLTVDEYGKDLHLNPAATYDCCLAGNDLIRNGQASQQLVAISDETAAANIEAIAAGGLNLSAGDLFELGPIREVYEENPDLALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAS2</accession>
    <name>A0A132PAS2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000064">
        <property type="protein sequence ID" value="KWX19414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047041234.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19414">
        <property type="protein sequence ID" value="KWX19414"/>
        <property type="gene ID" value="AFM11_35995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6576"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13701">
        <property type="entry name" value="DDE_Tnp_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="256" mass="27633" checksum="FED729E5310686BC" modified="2016-06-08" version="1" fragment="single">MIAQAAATARAAGVTGQILVRGDSAYGNSTVVTACHRAGVRFSLVLTKTAAVAAAIDAIPETAWTPVNYPGAVRDPDTGAWISDAEVAETTYTAFGSTKTPVTARLVVRRVKDARFLDALFPVWRYHPFFTNSDEPVDAADITHRRHAIIETVFADLIDGPLAHMPSGRFGANSAWILCAAIAHNLLRAVGVLAGGAHAVARGATLRRKIITIPARLARPQRQPILHLPAHWPWTEHWLTLWRNTIGYSPPEIATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB18</accession>
    <name>A0A132PB18_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000044">
        <property type="protein sequence ID" value="KWX19506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010596912.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19506">
        <property type="protein sequence ID" value="KWX19506"/>
        <property type="gene ID" value="AFM11_35435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5820"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="147" mass="16532" checksum="ABE197AA5B6A1539" modified="2016-06-08" version="1">MNTPVMTIGDLARRTGVPAKVLRRHHDLGLIYSLGRSRAGYRLFDEHALWCVEVIATLRGLGLTEAEIRQLAATCDDSARPVGPQLAELLARSRTRIEDRIRDLDEQRRRIDEFEHHHHDALTRATSHDRAAAPPWVPDPRTCGCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBA1</accession>
    <name>A0A132PBA1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859544.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19590">
        <property type="protein sequence ID" value="KWX19590"/>
        <property type="gene ID" value="AFM11_34915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5712"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="137" mass="14141" checksum="DC1135A9274533F4" modified="2016-06-08" version="1">MTTQTGSDVMAQFLPQSPFVTKLGIVAESLDGPEVRLRMPWDPSNVTLADMVHGGAIATLADVTVMVAAWAGAAVPDSLRGVTVSMSISYLAPARATDLLGVGRVLREGRSLVSCDVDIVTPGGDAVAKAIATYKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBE8</accession>
    <name>A0A132PBE8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859309.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17280"/>
    <dbReference type="EnsemblBacteria" id="KWX19655">
        <property type="protein sequence ID" value="KWX19655"/>
        <property type="gene ID" value="AFM11_34515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5248"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025333">
        <property type="entry name" value="DUF4239"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14023">
        <property type="entry name" value="DUF4239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="261" mass="28176" checksum="1EF2138E96E55C5C" modified="2016-06-08" version="1">MGDFGLIGAWLLLAVVIVGGVIIAVGSVLIASRIIARDARPEHNSILSPFLTVVGLIYGAVLGFTVVVGWQQYLSAETNVATEASILKTMYRQTVAMPQPEQSEVRAQIRKYATAMQGPEWGKNEFGNISNDGRAALTAMYRIVGSGKPSDATSAINQPFLSQLTELSTIRSARILDAKPRIPPLLWCALVFGGFVLIALTSFMRLADNRAHIILVSAVTMLLALLLYLIFVLDHPFGPMGVTPQPFSEAFAVFDLVDQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBK2</accession>
    <name>A0A132PBK2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859479.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10940"/>
    <dbReference type="EnsemblBacteria" id="KWX19627">
        <property type="protein sequence ID" value="KWX19627"/>
        <property type="gene ID" value="AFM11_34795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5308"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="561" mass="61732" checksum="D00A9800FF1B9A61" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBR6</accession>
    <name>A0A132PBR6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859018.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02455"/>
    <dbReference type="EnsemblBacteria" id="KWX19769">
        <property type="protein sequence ID" value="KWX19769"/>
        <property type="gene ID" value="AFM11_34005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5138"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="189" mass="20347" checksum="B0DF4C03917A32EB" modified="2016-06-08" version="1">MGRAGARLREFRRERGLSLTEVAARAEVTKGFLSLAERGMTNVSVPVLMRICDALEIGIGDLFEYPSAPVVRSGAGAPLEMGGVDVREELLTPKAERHVQVMHTVMRPGGGSGGAYRLDAATVFVYVLRGRLSIAVDGENTVLDTGDCLTFDATRLHDWHNPTDGEAEVLWTIAPPVGAEDFRAAVRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBS1</accession>
    <name>A0A132PBS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859064.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02535"/>
    <dbReference type="EnsemblBacteria" id="KWX19783">
        <property type="protein sequence ID" value="KWX19783"/>
        <property type="gene ID" value="AFM11_34085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5154"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="29701" checksum="D974F905CD37C695" modified="2016-06-08" version="1">MSAKVWFITGASRGFGREWTIAALQRGDKVAATARDTSTLTDLADKYGDALLALRLDVNDREADFAAVKQAHDHFGRLDIVVNNAGYGQFGFIEELSEAEAREQIETNVFGALWITQAALPYLRAQGSGHIIQVSSIGGITAFPLVGMYHASKWALEGFSQSLAQEVAPFGIHVTLIEPGGFDTDWAGSSAKHATPLPAYDEAREAAQRARAQRTAKSGDPKASAAAVLKIVDAENPPLRVFFGELPLQLAKADYESRLKTWEEWQPVSIEAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBU5</accession>
    <name>A0A132PBU5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859113.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02560"/>
    <dbReference type="EnsemblBacteria" id="KWX19799">
        <property type="protein sequence ID" value="KWX19799"/>
        <property type="gene ID" value="AFM11_34110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5159"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="165" mass="18112" checksum="88BDD8B3A434D9C8" modified="2016-06-08" version="1">MRLKAAAQPLLPHLYGEPGETRSQRIIRRVRIGIVVVACLVTLQSVLLVLGAWRNDRQIERNMGVAAAEVLSAGPRRSTIEFVTPDRVTYRPELGVLYPSELDTGMRIYVEYDKNDPDLVRVRDRDASLAIIPAGSIAVVGWVVAGAALMGLAVVQRRLNPSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBW5</accession>
    <name>A0A132PBW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3'(2'),5'-bisphosphate nucleotidase CysQ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33750</name>
        <name evidence="4" type="ORF">AWC31_08005</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858859.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08005"/>
    <dbReference type="EnsemblBacteria" id="KWX19821">
        <property type="protein sequence ID" value="KWX19821"/>
        <property type="gene ID" value="AFM11_33750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10113">
        <property type="protein sequence ID" value="ORX10113"/>
        <property type="gene ID" value="AWC31_08005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5087"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX10113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="253" mass="27441" checksum="A9ACFE4B820201FB" modified="2016-06-08" version="1">MTLSDADVAAAVAKEAGELLLAVRDEVGFYDPYYLGDEGDRRSNALILDRLAQARPGDSVLSEEAVDDLARVEADRVWIVDPVDGTREFSLPGREDWAVHIALWQRSLGPHGGLSDAVVALPARGEVYRSDTVTPPPPRQDGPILITASSNRPPPVLWRMREHLDFRMVRIGSAGAKAMAVVRGDVDAYIHAGGQWEWDSAAPAGVVLAAGLHASRLDGSELRYNRPDPYLPDFVMCRPELASVLLDAIGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCA9</accession>
    <name>A0A132PCA9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpE</name>
        <name evidence="15" type="ORF">AFM11_33340</name>
        <name evidence="16" type="ORF">AWC31_02375</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036440957.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02375"/>
    <dbReference type="EnsemblBacteria" id="KWX19867">
        <property type="protein sequence ID" value="KWX19867"/>
        <property type="gene ID" value="AFM11_33340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13385">
        <property type="protein sequence ID" value="ORX13385"/>
        <property type="gene ID" value="AWC31_02375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5000"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX19867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX13385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="86" mass="8610" checksum="B3CA66A761985AD0" modified="2016-06-08" version="1">MELDPNAIITAGALIGGGLIMGGGAIGAGIGDGIAGNALISGIARQPEAQGRLFTPFFITVGLVEAAYFINLAFMALFVFATPGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCG7</accession>
    <name>A0A132PCG7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858387.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20019">
        <property type="protein sequence ID" value="KWX20019"/>
        <property type="gene ID" value="AFM11_32970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4924"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="32517" checksum="C40BECCD602FB893" modified="2016-06-08" version="1">MTTGQLGEFLRARRSRLRPEDVGLPRFGERRRVSGLRREELAQLAGVSVSYYTRLEQGQSVNASEAILDALADALKLDNHERRHLRELAAQRPQPTRRPPVERVSSLTRDLLRSLDNVPALVVGRRTDILAWNPLGHALFAGHVDPTLVDRPADRPNLARLLFLDPHTRDLYVDWPRKARAVVGNVRLVAGRHPEDALLAGLIGELSMQSQEFVSLWADHRVKPCEADTYDLRHPLVGSLTVTQQNLRVARNPEQSLCLVTTAAGSASADTMQLLARSVDGKNIQADSMAGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCN3</accession>
    <name>A0A132PCN3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859266.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11210"/>
    <dbReference type="EnsemblBacteria" id="KWX19742">
        <property type="protein sequence ID" value="KWX19742"/>
        <property type="gene ID" value="AFM11_34460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5237"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041065">
        <property type="entry name" value="GNAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18407">
        <property type="entry name" value="GNAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GNAT_like" evidence="1">
        <location>
            <begin position="269"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="338" mass="35227" checksum="4278CBC96D2ACBAD" modified="2016-06-08" version="1">MTTLARQHDCLLLDLDGTVFRGHEPVTGALDSLAEVDARVLYVTNNASRAPGQVAEHLKELGFRADADDVVTSAQSAARLLATQLPSGAKVLVVGTDALADEVSNVGLRPVRQFDEEPVAVVQGHSPQTGWPELAEAALAIRAGALWVAANVDLTLPNERGLLPGNGSMVAALKAATAQEPQVAGKPQPTLMNDALARGTFDTPLVVGDRLDTDIAGANAAGLPSLMVLSGVSTAAEALHAVVAERPDYIALDLRGLHAPAESLKVGPHPAWRIVLDGADATVYATGAEPTDSLSVLRATAHAVWAADVDHQHFAVLAGDDIARRALQQWSLLSVPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCY2</accession>
    <name>A0A132PCY2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31695"/>
    <dbReference type="EnsemblBacteria" id="KWX20193">
        <property type="protein sequence ID" value="KWX20193"/>
        <property type="gene ID" value="AFM11_32155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4758"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="22176" checksum="6BB0D001F2D045CA" modified="2016-06-08" version="1">MWRCTVAGLAEFPRDLVTLEEWDALELDEARRWELVEGGIVMTPRPRPLHQVVSFNLAQVIRAALPASLAVLLEVEVTVEARFPPTVRDPDLVVVKRSVVDRNPVRIDASDVVLVVEIVSPGSRRTDRVMKAYEYAKAGIEHYWIVDLDTDPDERFLAHVLRGDAYHRVGSLDEDRVRTEEPLALDFTLEDLTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD05</accession>
    <name>A0A132PD05_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclohexanecarboxylate--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857963.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31890"/>
    <dbReference type="EnsemblBacteria" id="KWX20209">
        <property type="protein sequence ID" value="KWX20209"/>
        <property type="gene ID" value="AFM11_32005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4727"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="45"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="467"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="555" mass="61080" checksum="B3EB0C8DD9CCAB70" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD53</accession>
    <name>A0A132PD53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">K+/H+ antiporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_31485</name>
        <name evidence="7" type="ORF">AWC31_26065</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857527.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26065"/>
    <dbReference type="EnsemblBacteria" id="KWX20259">
        <property type="protein sequence ID" value="KWX20259"/>
        <property type="gene ID" value="AFM11_31485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14646">
        <property type="protein sequence ID" value="ORX14646"/>
        <property type="gene ID" value="AWC31_26065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030151">
        <property type="entry name" value="NhaP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="5">
        <location>
            <begin position="399"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX14646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="498" mass="52460" checksum="1003294882A19F4D" modified="2016-06-08" version="1">MSLNQLYLTLLVGGLVLLASIVGTRVATKVGFPSLLLFLLVGVVLGVDGIGLDFDNVELARNVCTAALAVILVEGGLTTRYSDIRQVLAPAASLATLGVLISTLVTAVGAHLLLDMHWQLALLLGAIVASTDAAAVFSVLRVLPLPRRLAGLLEAESGFNDAPAVILVLMFSVVPFVLDPEGAVTDLIYELLAGIALGLAVGFVGAQALRRIALPASGLYPIATFGLGLVAFAAAGSAHASGFIAAYLAAVVLANSGLPHRSATRSFAEGVGWLAQIGLFVLLGLLVNPHDLGSDIIPAIVIGLVLLLVARPLSVMLSLVAFRIPFREQLFLSWAGLRGAVPVVLATFPIVAGVPDSYRLLNIVFVLVVIFTLVQAPSLRIVAHGLGLVSRDNTREIQVEAAPLDVIDADLLTMTVRPGSRLHNVTILELRLPDPAVITLIIRNGHTFVPLPDTRIAVGDELLIVTTSRTRAAAEARLRAVSRRGKLAYWFDEYGHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDE2</accession>
    <name>A0A132PDE2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857159.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26585"/>
    <dbReference type="EnsemblBacteria" id="KWX20355">
        <property type="protein sequence ID" value="KWX20355"/>
        <property type="gene ID" value="AFM11_30865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4075"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="256" mass="27416" checksum="6DCDD1EEBCCB73E5" modified="2016-06-08" version="1">MWASGDYPKLAAELVSPLGPVLVQACGIGPGDRVLDVAAGTGNAAIPAAQTGASVIASDLCPELLEHGRALAAERGVELEWREANAHQLPFGDDEFDVVMSCIGVMFAPFHQQAADELIRVCKPGGRLGVLSWTPEGHIGRLFATMKPYVPAPPPGAQPPPLWGQEDHVRGLLGDRVGDVVTDRRTLTVDHFADGAAFRDYFKSVYGPTIAAYRNIEGNEDRVAALDADIARIGDDFLQGGSSMEWEYLLVTARKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDT5</accession>
    <name>A0A132PDT5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_30495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00500"/>
    <dbReference type="EnsemblBacteria" id="KWX20499">
        <property type="protein sequence ID" value="KWX20499"/>
        <property type="gene ID" value="AFM11_30495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3999"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="146"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="247" mass="26413" checksum="B502158ABE0A6BB6" modified="2016-06-08" version="1">MSDTATAATSFGVLLIEGGTGCADLATDSLRREGILVTIAAGGTGALLAIVAKAQPQMIIVEVGASVADTMSLCRYLRSVSDAHIAVLTAGHDAQTTIAGFDAGADEVFAEPLRTGEIACRVRTFIGHRHRGSVQRSLGRAPEESDGPRRFGPLTIDADRRQVFVSGRQIDLTRTQFDILATLARNPDRLTTRQELQNAVWGPSWSGSSNNIDVHIGHLRRKLGDDPAHPTLVLNVRGVGYRLPMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE78</accession>
    <name>A0A132PE78_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856559.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25140"/>
    <dbReference type="EnsemblBacteria" id="KWX20594">
        <property type="protein sequence ID" value="KWX20594"/>
        <property type="gene ID" value="AFM11_29800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3852"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="33"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="261" mass="28310" checksum="DD9690F13FC54B23" modified="2016-06-08" version="1">MTSTLGDSKQVLMQRALDGLSNHIEDSALTIRQKLALTCRALFDAGHDSGLAGQITARAEAPGTYYTQRLGLGFDEITDENLLLVDEDLNVLDGSGMANPANRFHSWIYRARPDVQCIVHTHPFHVAALSMLEVPLKVSQMDIAPLYDDCAFLADWPGVPVGNEEGEIISAALGDKKAILLAHHGHVVAGASVEEACSLAMLIERGAKLQLAAMAAGTVADLPPRLAREAHDWTLRPKRSQANFAYYARRALVRHPDAITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE99</accession>
    <name>A0A132PE99_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20651">
        <property type="protein sequence ID" value="KWX20651"/>
        <property type="gene ID" value="AFM11_28885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3657"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="79" mass="9255" checksum="24FC0854BC9CD9C0" modified="2016-06-08" version="1">MVGPQLLDQQAVASLVHLGWVGEPVAARFTWAHYLRYCELLGDWATQGDVAVELVEMWLVRRWRERITARRSRHVQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEK8</accession>
    <name>A0A132PEK8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011331216.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20724">
        <property type="protein sequence ID" value="KWX20724"/>
        <property type="gene ID" value="AFM11_29390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3769"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="463"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="555" mass="60997" checksum="1C2A6D20BBD52634" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEU2</accession>
    <name>A0A132PEU2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RecBCD enzyme subunit RecC</fullName>
            <ecNumber evidence="6">3.1.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Exonuclease V subunit RecC</fullName>
            <shortName evidence="6">ExoV subunit RecC</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Helicase/nuclease RecBCD subunit RecC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recC</name>
        <name evidence="8" type="ORF">AFM11_28655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.</text>
            <dbReference type="EC" id="3.1.11.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RecC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.5" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856208.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32885"/>
    <dbReference type="EnsemblBacteria" id="KWX20859">
        <property type="protein sequence ID" value="KWX20859"/>
        <property type="gene ID" value="AFM11_28655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3612"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009338">
        <property type="term" value="C:exodeoxyribonuclease V complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01486">
        <property type="entry name" value="RecC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006697">
        <property type="entry name" value="RecC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041500">
        <property type="entry name" value="RecC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17946">
        <property type="entry name" value="RecC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000980">
        <property type="entry name" value="RecC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01450">
        <property type="entry name" value="recC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecC_C" evidence="7">
        <location>
            <begin position="773"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117415" checksum="F4C29B29CED2B471" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF76</accession>
    <name>A0A132PF76_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855832.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10615"/>
    <dbReference type="EnsemblBacteria" id="KWX20996">
        <property type="protein sequence ID" value="KWX20996"/>
        <property type="gene ID" value="AFM11_28070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3489"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="491" mass="50379" checksum="D0C94B78C54B6541" modified="2016-06-08" version="1">MDSKFAFELAGVDAIGQARLAAAGDVTATELLDAAIVRLEAARTLNAVIADLFDRGRTQATALDASGVLRNGQAGPLAGVPFLLKDLGAALAGAPEAMGSRALRDHVATDSAWTVQRYLEAGLVVFGKTNTPEWGNHCTTEPVLFGPTANPWSSSVTPGGSSGGSAAAVAAGVVPAASGGDGTGSIRVPASCCGLVGLKPRRGRASFAPDGGHGLEGLVNNHALTRTVRDCAALLDVIAGSVTGDPYSAPAPDEPFLQAVSRDPQPRRVLMSTSSPFPTERIDPAVVAAVEQTGRLLESLGHQVQAGGPSIEPDAVADAVAVLHNVSNAQLHAFATGHLGREPLDDEFEPSTWVMIREGFTTTGMAYADAIAAVHAQTRRFAAGMAGHDVLLVPTLLTGPPPYALLNQPRGTTRAFFDVEFATTGWTALANVTGWAAISLPLGTTDDGLPIGVQLMAPDEAVLLGLAAQLEQAAPWAARKPAGWVANDGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF88</accession>
    <name>A0A132PF88_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855982.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20983">
        <property type="protein sequence ID" value="KWX20983"/>
        <property type="gene ID" value="AFM11_27840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3442"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="416"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="500" mass="52144" checksum="BEFD565CE8241D2E" modified="2016-06-08" version="1">MALPGTTNPREEQSVLSALKTPRRLRTEVLAGLVVALALIPEAISFSIIAGVDPRVGLFASFTMAVTIAIVGGRPAMISAATGAVALVVAPLVHSHGLDYLIAAVILAGVLQLVLGGLGVAKLMRFVPRSVMVGFVNALAILIFISQLPHLLGVPWLVYPLVVVGIAIIVVLPKLTTVIPAPLVAIVLLTAACLGFGWSVPNVGDEGELPSSLPALLFPDVPLTLNTLAVIAPYALTMAVVGLLESLMTAKLVDDITDTHSNKSREALGQGVANIVTGFFGGMGGCAMIGQTMINVKACGARTRISTFLAGALLLGLVVGLGDIVAQIPMAALVAVMIMVSVATLDWHSVNPKTLRRMPKSETAVMAATVAVTVATHNLAYGVVVGTLAAMVLFARRVAHLTDVVEVSHPDADTRVYAVKGELFFASSNDLVYQFDYAGDPANVVIDMSEAHIWDASTVATLDAITTKYAAEGKNVTIIGMNDNSAERHRRLSGRLAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFF6</accession>
    <name>A0A132PFF6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ORF">AFM11_27045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855274.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06890"/>
    <dbReference type="EnsemblBacteria" id="KWX21043">
        <property type="protein sequence ID" value="KWX21043"/>
        <property type="gene ID" value="AFM11_27045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3283"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX21043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="316" mass="32437" checksum="A148989D788A4B34" modified="2016-06-08" version="1">MFEPTCRAAGIAIGYLADLLLGDPRRGHPVAVFGAGAARLERLTYADDRRAGVLHTGLLLSGLALFGAAAGRSAPVTALATFVALGGTSLNRVGGQMATVLEAGDLDGARRLLPSLCGRDPAALDAAGLTRATVESLAENTSDAQVAPLLWAAVAGVPGVLVYRGANTLDAMIGHRSPRYLRFGWAAARFDDVVNYLPARLTGLLVVACAPVVDGSPRAALRAWRRDAARHPSPNAGVAEATFAGALGVRLGGPTQYAHQLEIRPTLGDGRVPEVIDVGRAVRLSRAVQAAAAGVAVLTAGLSAAVRNGRRASPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFI2</accession>
    <name>A0A132PFI2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28280</name>
        <name evidence="4" type="ORF">AWC31_10830</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10830"/>
    <dbReference type="EnsemblBacteria" id="KWX20967">
        <property type="protein sequence ID" value="KWX20967"/>
        <property type="gene ID" value="AFM11_28280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08975">
        <property type="protein sequence ID" value="ORX08975"/>
        <property type="gene ID" value="AWC31_10830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3530"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453209" evidence="1">
        <location>
            <begin position="22"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="2">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX08975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="127" mass="13066" checksum="7EF983B56DA758F2" modified="2016-06-08" version="1">MKLMAVFCTLAGLLTVLVACGQSDDSVRGTGTAILTASPTTEPASDGPTITIEGMGFSGGLTVAPGTQITIVNNDEVEHSVTARTGDAFDVHVDGKQRATLTAPSEPGEYAFYCVYHPAMIGTLTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGN5</accession>
    <name>A0A132PGN5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_25200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854204.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27520"/>
    <dbReference type="EnsemblBacteria" id="KWX21509">
        <property type="protein sequence ID" value="KWX21509"/>
        <property type="gene ID" value="AFM11_25200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2401"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453323" evidence="9">
        <location>
            <begin position="30"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="43"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX21509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="295" mass="30559" checksum="59A32648C4B8DECF" modified="2016-06-08" version="1">MGRIVCALIVSVTAVFTALTTVAAPVAGADIDVQQVGSVPIPDGPAQAWIVADMDTGQVLAGRNENVRYAPASTIKTLLAQVVLDEVPLDTTIVADEADTHVECNCAGVAPGHTYTARQLLEAALLASGNDAANTLARMLGGQEAAVAKMNAKAAALGAHGTNVVTPSGLDGPGMPFWSTPHDLAVIFRAAMANPVFAQITAMPSTVFPTKTGDRVLVNQDELLHRYPGAIGGKTGFTDIARKTFVGAAQRDGRRLVVALMFGLVKEGGPTYWDQAAALLDWGFAQDRSASVGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGT6</accession>
    <name>A0A132PGT6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_25280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854240.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27600"/>
    <dbReference type="EnsemblBacteria" id="KWX21523">
        <property type="protein sequence ID" value="KWX21523"/>
        <property type="gene ID" value="AFM11_25280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2418"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="270"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="477"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="546" mass="58905" checksum="352D6A494B4262F1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH57</accession>
    <name>A0A132PH57_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">AFM11_25755</name>
        <name evidence="14" type="ORF">AWC31_36140</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003882795.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36140"/>
    <dbReference type="EnsemblBacteria" id="KWX21332">
        <property type="protein sequence ID" value="KWX21332"/>
        <property type="gene ID" value="AFM11_25755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12044">
        <property type="protein sequence ID" value="ORX12044"/>
        <property type="gene ID" value="AWC31_36140"/>
    </dbReference>
    <dbReference type="GeneID" id="44296805"/>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3015"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX21332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX12044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="84" mass="9304" checksum="AF279DEBD2A05BC5" modified="2016-06-08" version="1">MDWRHKAVCRDEDPELFFPVGNSGPALAQIADAKLVCNRCPVTTECLTWALDSGQDAGVWGGMSEDERRALKRRNARTKARTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHF5</accession>
    <name>A0A132PHF5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21779">
        <property type="protein sequence ID" value="KWX21779"/>
        <property type="gene ID" value="AFM11_23275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2011"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="117" mass="12606" checksum="1E37133CA45E9D35" modified="2016-06-08" version="1">MLWNNVVDPVGARGDARPFDFDDAHAYVGAVLGLWAGAAHKVHILRADYTPAKWLASMGSGGCDWTAPLAKPWRGDCFGYATNALVFARGQYVVAMRTCASCFGWLVAGAPLPARHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHN7</accession>
    <name>A0A132PHN7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">AFM11_23740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853351.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29905"/>
    <dbReference type="EnsemblBacteria" id="KWX21860">
        <property type="protein sequence ID" value="KWX21860"/>
        <property type="gene ID" value="AFM11_23740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2105"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="299"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="331"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="413"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX21860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="431" mass="46282" checksum="C531D5C49AD2811D" modified="2016-06-08" version="1">MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGENFALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELKGLEERGVDTSGLLISADAHLLMPYHVAIDKVVERWAGSKKIGTTGRGIGPCYQDKIARIGIRVADVLDETLLAEKIEAALEFKNQVLVKIYNRKALEPAEVVENLLTQAEGFKHRIADARLLLNQALENGETVLLEGSQGTLLDVDHGTYPFVTSSNPTAGGAAVGSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDEHGAYLAKTGGEVGVTTGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYKVDGKRTDEMPMTQSDIHRAEPIYEELPGWWEDISGAREFDDLPAKARDYVLRLEELAGAHVSCIGVGPGREQTIVRRDILAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHQ3</accession>
    <name>A0A132PHQ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oleandomycin glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853272.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28325"/>
    <dbReference type="EnsemblBacteria" id="KWX21833">
        <property type="protein sequence ID" value="KWX21833"/>
        <property type="gene ID" value="AFM11_23600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2076"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="381" mass="41177" checksum="464130AB27249D08" modified="2016-06-08" version="1">MYPHLAVIRELVDRGHRVSYLVSGHLAWLARPTGADIVECGSVLPGAPGAPESWGDENDPVTGMRMFLDEAIHVLPQLHAHLDRDRPDLVLYDIGGMAGPVAAAQWGVPAAQLSPSEVAWDTYHEDMAEILDPILNSPTGVAYRQAFEDWLAASGSGLTFDEVTGVPRRCLALIPRVMQRHADRVGDRYRFVGPCIDPRREDPRDWTPPPGDGPLALLAFGTAYTQRADIYRNVIDALDGLDWRLTLASGRAGADELGSVPPWVQLCPTVPQPAVLRLADCFFTHAGMGSCTEGLWYGVPMVALPQAVDQPANAARLETLGVGRHLQAHLPAVAEIRDAALAVTSDEQIRLRLNAIQEEIQASGGPVQAADAVEDVAAGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHS4</accession>
    <name>A0A132PHS4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_23755</name>
        <name evidence="6" type="ORF">AWC31_29890</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000018">
        <property type="protein sequence ID" value="ORX13673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853423.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29890"/>
    <dbReference type="EnsemblBacteria" id="KWX21886">
        <property type="protein sequence ID" value="KWX21886"/>
        <property type="gene ID" value="AFM11_23755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13673">
        <property type="protein sequence ID" value="ORX13673"/>
        <property type="gene ID" value="AWC31_29890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2108"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX13673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="63" mass="6732" checksum="804717740199B373" modified="2016-06-08" version="1">MRVEADRDACIASGNCVMVSDAVFDQDDDGVVVVLVDDIPDEEIDHAREAVKLCPASALKLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHV2</accession>
    <name>A0A132PHV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852744.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08705"/>
    <dbReference type="EnsemblBacteria" id="KWX21938">
        <property type="protein sequence ID" value="KWX21938"/>
        <property type="gene ID" value="AFM11_22505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1851"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="386" mass="42374" checksum="7C6F3CB08A4F7FE0" modified="2016-06-08" version="1">MRTFTADERRARLARRHFLTAPADSITATAAGLVGLHSTDPATPYLSLWARLPGFAIADLDTELYERRSVIKHLAMRRTLWMVHTGDLATIQAGASDRVAGNELRKLIGDVEKAGVAPDGARWVSAACAAVLRHLQQHGPTSAKELRAALPELSGSHDPAPVKRWGGEIPLGPRVLTVLGVQGEIVRGPNDGAWTVSRPRWTTTADWLGTKPEPTSEDAARTELVRRWLAAFGPATVTDIKWWFGNTLTWARTALRDLEAVEVDLEGIPGYALPDDLEVEPDPGPWCALLPGLDVTTMGWFDRDWYVGPHRSQVFDTNGNAGPTVWCNGRIVGGWRQDENGRVVLCLLEETGSAMNRALQRKADELTEWLAAARVNPRFPSPVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI30</accession>
    <name>A0A132PI30_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalt-precorrin-6X reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_22835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852859.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08365"/>
    <dbReference type="EnsemblBacteria" id="KWX21996">
        <property type="protein sequence ID" value="KWX21996"/>
        <property type="gene ID" value="AFM11_22835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1920"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="241" mass="25658" checksum="45AA379420588E82" modified="2016-06-08" version="1">MKILLLGGTGEARALAAALHPDVEVISSLAGRVPDPAMPVGEVRVGGFGGVDGMRRWLMDSAVDGVVDATHPFAATITAHAAQVCAELRLPHLVLARPAWPPGDAILVGSDTEAAKVITQQRFSRIFLTTGRSGTTAFRDVDAWFLIRAVTEPDAETLPARHELLLSRGPYHYEGELALLREHDIDALVTKNSGGDMTQPKLRAAATAGVAVVMVDRPPLPEGVRSVATVDEAQAWVRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI67</accession>
    <name>A0A132PI67_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852887.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08290"/>
    <dbReference type="EnsemblBacteria" id="KWX22011">
        <property type="protein sequence ID" value="KWX22011"/>
        <property type="gene ID" value="AFM11_22910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1935"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="144" mass="15550" checksum="83B9E817DD095B7F" modified="2016-06-08" version="1">MPQATLEAQQRTRSFARVLGPFVALATLIIAIRLPNLTGLLGGLFDNAVLPWMLGAAMLVMGLVVIAFHQYWYSVTAVLISLFGWFVALRGLAMMAIPSAIDSGANATVTSPGLLVAARVFFLLLTAMGLWLTYVGWRREPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIM2</accession>
    <name>A0A132PIM2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852568.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04930"/>
    <dbReference type="EnsemblBacteria" id="KWX22200">
        <property type="protein sequence ID" value="KWX22200"/>
        <property type="gene ID" value="AFM11_22170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1783"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025568">
        <property type="entry name" value="DUF4334"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025951">
        <property type="entry name" value="GXWXG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14232">
        <property type="entry name" value="DUF4334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14231">
        <property type="entry name" value="GXWXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXWXG" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4334" evidence="2">
        <location>
            <begin position="122"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="183" mass="20225" checksum="75E477D713A917FC" modified="2016-06-08" version="1">MLQELFSTVPTITADALEAFDAAEAVEPEFMIGTWHGAELPTGHPMDGLLAASGWWGKQFIDAETVHPLLFPARDSTGLWALNPSLAFGGLGLSTKLPLLRNRSMVAPIAALRPVLQTRSAKARLRTTRYRGVDTATMIYDQLPINDVFRKLSDDAVIGAMDLRGSRKPYFFVLRRDNSRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIN1</accession>
    <name>A0A132PIN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852608.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04425"/>
    <dbReference type="EnsemblBacteria" id="KWX22218">
        <property type="protein sequence ID" value="KWX22218"/>
        <property type="gene ID" value="AFM11_21620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1672"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AhpC-TSA" evidence="1">
        <location>
            <begin position="28"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="180" mass="19696" checksum="8E7406B70AB0E0EB" modified="2016-06-08" version="1">MNPPATIAGYEFRTVTGEHIPVPDPAHLVHLQFRRFAGCPICNLHLRSFVSRHDEISAAGIREVVFFHSPESELAEHTADLPFATVADPDKETYRRFGVESGVRALLDPRSWPAIIGGSAQTLRGRFRAPAARQPGGRLGLPADFLVGRDGTVLAAKYGAHADDQWSVDELLTQAAAMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIP4</accession>
    <name>A0A132PIP4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852517.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22173">
        <property type="protein sequence ID" value="KWX22173"/>
        <property type="gene ID" value="AFM11_22030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1754"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="305" mass="33460" checksum="DE3A388F4069D47A" modified="2016-06-08" version="1">MDDPVAWPSLADQIDIATSLFGERGVRMVGAWLAEQTARIDDLQFARTFSDHITLPGIRPADYAHRHLRTGRGDLIGGIRFYCRDLARPFVEVVAHSFEDVAALADCVRAEWAAFAPGYLRLRARPGRITGPGVVLDVSIHAARHRDITACDGRVRLHPFTDAQQAVDLVSRRYEHLAATQPALAHNITPADPADIRQWHDDGRLRAIEVCDEIVGAIAIVPGAVGWLGGDEVNEEVISAEHCGHGYAVSAQTAWAAYVATDHSQMLVGTIDRHNPASRKTAERAGRPRVLDDVFVALRGRVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ12</accession>
    <name>A0A132PJ12_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_21205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852221.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06570"/>
    <dbReference type="EnsemblBacteria" id="KWX22340">
        <property type="protein sequence ID" value="KWX22340"/>
        <property type="gene ID" value="AFM11_21205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1587"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="348" mass="36993" checksum="71661AF55D111A5D" modified="2016-06-08" version="1">MANIKDVARYANVSPTTVSHVLNGRGRVAKETRDRVLEVAERLGYTASAHAQQLVTRRSRIIAIQMPDLDVSGRGTALVPKSESEYFLELINGAAAAATDARYALIVVSSGVDASSMRSFGVDGMIIVDPKGSEQFLQGSFADQYPVVTTGEPVVAAARPCFVVDNDHEAAARDMLDHFVAQGCSQPAIIVDTTSRSYIRDIQHAYGEWCNANDVRPAVVAVAEASPNEMGKALSSLRSGPSPADSIYTSSDECAIALLDAAREAGISVPGHLALASAVDSSILRVTNPPVTGVFLHPRDIGARAVESLTDLIARKDPDCQLPPLDSNRTLIPTRLVVRASTAMEANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ31</accession>
    <name>A0A132PJ31_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22359">
        <property type="protein sequence ID" value="KWX22359"/>
        <property type="gene ID" value="AFM11_20725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1484"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="197" mass="21340" checksum="61E23C1C1933797F" modified="2016-06-08" version="1">MPAPAHADPLPYGPDTCIQGYVWREARSGDTVCVTPETRSTVAQQNANPKAHKDPNGAYGPESCAQGYVWREAFDGDTICVTPDFRQQMFDDNAAASSRKQANAPEPTPQAAESTIVLEVTGSGEVYSIWSIPFGQVGGDHTKIPFSKSYPLPADEDYVSMNWNSRDDHAKGCRITVDNKVVVNNPQGTGGTCVFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ40</accession>
    <name>A0A132PJ40_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_21045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852171.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06410"/>
    <dbReference type="EnsemblBacteria" id="KWX22321">
        <property type="protein sequence ID" value="KWX22321"/>
        <property type="gene ID" value="AFM11_21045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1555"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="133"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="426" mass="48225" checksum="B282576C8072B2E1" modified="2016-06-08" version="1">MAWDFSTEPEFQEKLDWVKQFCAEKVEPLDHVFPYAVRSPDPAVKAYVRELQQEVKDHGLWATFLDRDLGGPGFGQLKLGLLNEIIGRYAGAPHMFGASAPDTGNMEMLAAYGTEEQKERWLRPLLNQDMFSAYSMTEPQGGSDPNLFKTHAVRDGDEWVINGEKWFTSAGRVADLLFVMCTNGMFVVPRETPGVEIMPEPRNHNHIIYRDVRVPLDHLLGPEDGAKTLAQRRLGGGRIHHAMRTIAQCNLAFDMMCERALSRESHGKVIAEHQMVQEKIAESYAMIKMLRLFVLETAWKIDQTSALEARTEIAAVKFTMAKVLREVSFNALHILGSLGTTDLTPIQAMYAGAPTMGIADGVDEVHKATVARRVLRDYHPHEGNFPTEFIPYKREEARQKMQPVLESRPELAAAAEAYRKYFERHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJD8</accession>
    <name>A0A132PJD8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_21165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06530"/>
    <dbReference type="EnsemblBacteria" id="KWX22374">
        <property type="protein sequence ID" value="KWX22374"/>
        <property type="gene ID" value="AFM11_21165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1580"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="55"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="27267" checksum="C566647DA9DF45E7" modified="2016-06-08" version="1">MSTFRVTRAWLVLGAGLVLWEIVVRWLAVPPYVLPAPSAIVDSFLDHPALFLSGMWVTAKMSLIGFGVAIVIGVALAVLMARSAIFEELSYPFLNIIRVMPTVAIAPLLIIWFGRTGLPIVICSCLIAVFPIIVDVTHGLTSVERDLINMMKLSNASEFSILTRIRIPNCLPYLFSSFRVAAPGAVVGTLLGEFIGSKTGLGYLITVYSAQLNTAAVFVLALLSCLLGILFFNICVWAERLLVPWKTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJH4</accession>
    <name>A0A132PJH4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22499">
        <property type="protein sequence ID" value="KWX22499"/>
        <property type="gene ID" value="AFM11_20330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1399"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="26477" checksum="2FC670E2C4CD7DAC" modified="2016-06-08" version="1">MGKQRPCLAGMMAAVGIVAIYRGGLRPWMYTWGAGPEEVTGVLPGDELVLPDSPRTTRALTIDAPVDAVWPWLAQIGEDRGGFYSYAMLERAVGAHVYNANRVHPEWQDLHVGDSIWLARRYGDGARQTVALVEPESDLVLMAPADFERVQRGEKASGAWSFHVRRIDGWTRLIVRGSGDMAGNPLFDIAHFVMERRMMCGIRHRAEQLYRDEPGGLPANHLATLPATPHGNSALQAQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJJ3</accession>
    <name>A0A132PJJ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851963.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22519">
        <property type="protein sequence ID" value="KWX22519"/>
        <property type="gene ID" value="AFM11_20455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1425"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="270" mass="28680" checksum="2A24C1C2D4ABB6BE" modified="2016-06-08" version="1">MSEKPTRAAVVAGVDGSEAAVKAAQWAADEALGRGVPLRLVYVTKPRHPSAEDYYADVHRGEAALQAAKAELESTGSALMIQTATVDGPAGRALIEESRTAAMICVGSVGIGRYAQSILGSTATELAEKSVCPTAIIRADDYGTPADTQWIVFAMTDPQDDAVVESAMSEARLRHAPVLALGDLRASSVFDGQIEALKQTYPDVHLYPITNEADVTHFLKKHDEAVQLAIVGSSDTAQIPRILGPFGRHRFHLFHHAASSVLVARRSATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJQ7</accession>
    <name>A0A132PJQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn-dependent protease with chaperone function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_19935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851869.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28580"/>
    <dbReference type="EnsemblBacteria" id="KWX22427">
        <property type="protein sequence ID" value="KWX22427"/>
        <property type="gene ID" value="AFM11_19935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1321"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453410" evidence="8">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="9">
        <location>
            <begin position="152"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="318" mass="33536" checksum="DDEB058C4CDE98FB" modified="2016-06-08" version="1">MSALAFTLVALALVGPVPAMLARASWPLRAPRAAIVLWQSIALAAVLSAFSAGIAIASRLFVPGPDGRPTATITSEIKVLGWPLWLLYVVVFTLTLLIGARLCVAVIQVAVATRRRRAHHRMMVDLLSRSRDAVPTHLCTSASGLRILDVAQPLAYCLPGVRSRVVVSEGTLNTLSDNEVTAILTHERAHLRARHDLVLEMFTAVHAAFPRFVRSASALDAVRLLIELLADDAAVRTAGPTPLARALVACAGGRTPSGALAAGGPTTVIRVRRLGGKPNSLVLSAIAYLAAVAVLVVPTVAVAVPWLTELHRLFSGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK07</accession>
    <name>A0A132PK07_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_18980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851583.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15070"/>
    <dbReference type="EnsemblBacteria" id="KWX22594">
        <property type="protein sequence ID" value="KWX22594"/>
        <property type="gene ID" value="AFM11_18980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1130"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453362" evidence="1">
        <location>
            <begin position="25"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="3">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="316"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="590" mass="61310" checksum="6628E0374C3DB66B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK59</accession>
    <name>A0A132PK59_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_19035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15125"/>
    <dbReference type="EnsemblBacteria" id="KWX22726">
        <property type="protein sequence ID" value="KWX22726"/>
        <property type="gene ID" value="AFM11_19035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1141"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="14"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="215" mass="23350" checksum="8C6B6A9E5A4A0FC6" modified="2016-06-08" version="1">MIADNLWPLAKAAITMTIPLTIISFAIGLVIALGVALARLSSNVVLSNVARLYISIIRGTPLLVQLFIVFFALPEFGVKIDPFPAAVIAFSLNVGGYAAEIIRSAILSIPKGQWEAAETIGLSYVGTLRRIILPQATRVAVPPLSNTLISLVKDTSLASTILVTELLRQAQIIAAPTFEFFALYGTAAVYYWVICLALSFGQSRIERRLERYVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKT0</accession>
    <name>A0A132PKT0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_18150</name>
        <name evidence="6" type="ORF">AWC31_12220</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851280.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12220"/>
    <dbReference type="EnsemblBacteria" id="KWX22854">
        <property type="protein sequence ID" value="KWX22854"/>
        <property type="gene ID" value="AFM11_18150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18752">
        <property type="protein sequence ID" value="ORX18752"/>
        <property type="gene ID" value="AWC31_12220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.987"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX18752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="138" mass="15447" checksum="13F314A4BB89AAEB" modified="2016-06-08" version="1">MTIPGPKLELTDDEWRAKLTPEEFAVLRRAGTERPFTGEYTDTKTEGVYECRACGAELFRSSEKFESHCGWPSFFDPANSDAVILRSDNSLGMRRVEVLCANCHSHLGHVFEGEGYPTPTDQRYCINSISLKLVPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKY5</accession>
    <name>A0A132PKY5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851417.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11795"/>
    <dbReference type="EnsemblBacteria" id="KWX22914">
        <property type="protein sequence ID" value="KWX22914"/>
        <property type="gene ID" value="AFM11_17675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.890"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="30101" checksum="BAE20552289B1EF5" modified="2016-06-08" version="1">MARADLAALLALGAALFIAIGDVIHQRSAHQVTDEPVSHVGLFARLLRDRQWWLGSLVAAVGFALQAAALGLGSVLLVQALLVTSLLFALPINARLAHRRVTRWEWLWAALLAGSVAVIVTVGNPTEGHARGPLEAWTLVIAVLGPALVLCLIGARIWSGATSAVLLAVVSGAMWGLFAVLTKGVVDHLGDGLWALLRAPELYAWAVVAVAGTVIQQSSFRAGALTASLPTMTVTEPIVASVLGVVVLGETLRPGEAGWLTLIVAVTAMVVATAALARGEAASEQAATSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKY7</accession>
    <name>A0A132PKY7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_16690</name>
        <name evidence="16" type="ORF">AWC31_01260</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850718.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01260"/>
    <dbReference type="EnsemblBacteria" id="KWX23009">
        <property type="protein sequence ID" value="KWX23009"/>
        <property type="gene ID" value="AFM11_16690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13191">
        <property type="protein sequence ID" value="ORX13191"/>
        <property type="gene ID" value="AWC31_01260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.688"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="14">
        <location>
            <begin position="6"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX23009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX13191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="242" mass="27425" checksum="98CFA2F43FC0EDB7" modified="2016-06-08" version="1">MSGWEIFWDVVPYVTLAIVVVGLWWRYRYDKFGWTTRSSQLYESRLLRIGSPMFHFGILVVIVGHIIGLVIPESWTRAVMSDHVYHIQAVTLGGLAGVTTLAGIALLVYRRRTTGPVFMATTANDKVMYVVLVLAIVAGVSCTFIGASPAGAEHDYRETVAPWFRSIWILQPRGDLMVQAPLYFHIHVMIALVLFCLWPFTRLVHVFSAPIGYLFRPYIVYRSRDVAGRGELVGSQPHRRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL19</accession>
    <name>A0A132PL19_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.117</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Tetrahydrodipicolinate N-succinyltransferase</fullName>
            <shortName evidence="4">THDP succinyltransferase</shortName>
            <shortName evidence="4">THP succinyltransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tetrahydropicolinate succinylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dapD</name>
        <name evidence="6" type="ORF">AFM11_16875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA</text>
            <dbReference type="Rhea" id="RHEA:17325"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.3.1.117"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850786.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01445"/>
    <dbReference type="EnsemblBacteria" id="KWX23041">
        <property type="protein sequence ID" value="KWX23041"/>
        <property type="gene ID" value="AFM11_16875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.728"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02122">
        <property type="entry name" value="DapD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019875">
        <property type="entry name" value="DapD_actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032784">
        <property type="entry name" value="THDPS_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038361">
        <property type="entry name" value="THDPS_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026586">
        <property type="entry name" value="Type2_DapD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14789">
        <property type="entry name" value="THDPS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03535">
        <property type="entry name" value="DapD_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_M" evidence="5">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="287"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-anhydride intermediate" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="314" mass="32277" checksum="D0970748D982A617" modified="2016-06-08" version="1">MTAASGVGLATIAADGTVLDTWFPAPELSADAPAGTVRLSGDDIPAEFAGLTGKDEDRNVEVVAVRTTIADLDDKPADTHDAYLRLHLLSHRLIAPHGANMDGIFGVLANVVWTNFGPCAVDGFETTRARLRRRGAVAVYGIDKFPRMVDYVTPTGVRIADADRVRLGAHLASGTTVMHEGFVNFNAGTLGTSMVEGRISAGVVVDDGSDIGGGASIMGTLSGGGTEVISVGKRCLLGANAGLGISLGDDCVVEAGLYVTGGTKVTTADGQTTKAKDLSGASNLLFRRNSLSGAVEVVKRDGTGITLNEALHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL38</accession>
    <name>A0A132PL38_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_16995</name>
        <name evidence="7" type="ORF">AWC31_01565</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850825.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01565"/>
    <dbReference type="EnsemblBacteria" id="KWX23061">
        <property type="protein sequence ID" value="KWX23061"/>
        <property type="gene ID" value="AFM11_16995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13244">
        <property type="protein sequence ID" value="ORX13244"/>
        <property type="gene ID" value="AWC31_01565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.752"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX13244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="224" mass="24618" checksum="4F17B3A8B7033FE4" modified="2016-06-08" version="1">MKTVVQALAFSVVGFVLIAALLFGPAGTFDYWQAWLFIAVFAILGTVYTIYLGLKNPEVLRRRMHSGPTAETRPAQKLIVLGIYVWFFGVAVLSALDHRFGWSQVPTAVALLGNALVAIGLGITMLVVIQNSYAAATITVEAGQEVVSTGLYALVRHPMYFGALIMMIGLPIALGSYWALILIAPGVPVLALRILDEEKALRHELAGYTEYTQQVRYRLMPYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLD6</accession>
    <name>A0A132PLD6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_15150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850125.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15770"/>
    <dbReference type="EnsemblBacteria" id="KWX23165">
        <property type="protein sequence ID" value="KWX23165"/>
        <property type="gene ID" value="AFM11_15150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7142"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="PTHR10543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="439" mass="48920" checksum="CB17A111C6E8DA47" modified="2016-06-08" version="1">MTETEINNGLPGEGAFFTKGNYAPVADELTEYDLPVDGAIPPELDGWYLRNGPNPRQASAHWFTGDGMIHGVRIENGAAKWYRNRWVRTESFIKDFPVYNPDGTRNLRSSLANTHVVNHAGKTLALVESSLPYEVTNDLETVGAYDFGGKLVDSMTAHPKICPTTGELHFFGYGSIFEPYVTYHQADANGELTINRPVDVKAQTMMHDFAMTAGHVIFMDLPVVFDLDIAINGGDMPYRWSDTYGARLGLLRRDDPFGEIRWFDIDPCYVFHVANAYEHGNKVVLQAVRYPELWRKDGDFDVPAVMWEWTLDLSAGTVTERQLDDYGVEFPRIDDRLAGLNARYSIAVGDNTWVRYDLTTGESVRHELGSGGPGEAVFVPGSGPADESNGWYLGYVYDPARNGSDLVILDASDFSGKPVARIKLPQRVPYGFHGNWISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLF1</accession>
    <name>A0A132PLF1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_15180</name>
        <name evidence="8" type="ORF">AWC31_15800</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850135.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15800"/>
    <dbReference type="EnsemblBacteria" id="KWX23170">
        <property type="protein sequence ID" value="KWX23170"/>
        <property type="gene ID" value="AFM11_15180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17880">
        <property type="protein sequence ID" value="ORX17880"/>
        <property type="gene ID" value="AWC31_15800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7148"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX17880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="512" mass="52444" checksum="ABBA14F580486510" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLR4</accession>
    <name>A0A132PLR4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_16355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850596.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22952">
        <property type="protein sequence ID" value="KWX22952"/>
        <property type="gene ID" value="AFM11_16355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.619"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="128" mass="14234" checksum="B9E00BA0E9B1E9CF" modified="2016-06-08" version="1">MTTPPPDPVAVWIDESGRLTSDLGSVDTRCTATIRAGHCPQRRQCVLLHRAPGPRLLFGELMSNLDDEAGIYLETHAKHIAADLISITVDHVGPDGPPGSWRYRLLPMRWKTADGWRDTDARLAIWPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLZ4</accession>
    <name>A0A132PLZ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16260</name>
        <name evidence="3" type="ORF">AWC31_16890</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850527.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16890"/>
    <dbReference type="EnsemblBacteria" id="KWX23359">
        <property type="protein sequence ID" value="KWX23359"/>
        <property type="gene ID" value="AFM11_16260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18072">
        <property type="protein sequence ID" value="ORX18072"/>
        <property type="gene ID" value="AWC31_16890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7377"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="276" mass="28414" checksum="17897F4D8ABF6E05" modified="2016-06-08" version="1">MGQLDGKVAFITGVARGQGRSHAIRLAGEGAAIIGVDICADIASNGYPMAKRAELDETVALVEAAGGKMVGSVADVRDFHQLKAALDAGVEQFGGLDIVCANAGIATMAFRELTIEEDLEMWTDVLDVNLVGSFHTAKAAIPHLIAGGRGGAIVFTSSTAGLRGFGGLQGGGLGYAASKHGIVGLMRTLANALAPHSIRVNTVHPTAVNTMMAVNPAMTAFLENYPDGGPHLQNPMPVSLLEPEDISAAIAYLVSDAAKYVTGVTFPVDAGFCNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM17</accession>
    <name>A0A132PM17_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MCE-family protein MCE1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_13930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23391">
        <property type="protein sequence ID" value="KWX23391"/>
        <property type="gene ID" value="AFM11_13930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="45"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="131"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="220" mass="23622" checksum="4AE59A790421CFE7" modified="2016-06-08" version="1" fragment="single">MTAPQAPLNKPKTPPYKLAGLVLALVAALVFALTWMQFRGVFEDKVQLTVMSGRAGLAMDPGSKVTFNGVPIGRLASVDVETVGDNPEAKLTLDVDPKYLKLIPENATAELRATTVFGNKYISFLSPENPSPERLSPSTPIQAQGVTTEFNTLFETITAISEQVDPIKLNETLTATAQALDGLGDKFGRSIVDGNDILADVNPRMPQIRRDITGLADLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMD0</accession>
    <name>A0A132PMD0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Betaine-aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_16250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850523.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16880"/>
    <dbReference type="EnsemblBacteria" id="KWX23357">
        <property type="protein sequence ID" value="KWX23357"/>
        <property type="gene ID" value="AFM11_16250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7375"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="17"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="475" mass="49640" checksum="2B2438C345F5FCDA" modified="2016-06-08" version="1">MTRPGAASDLGVGKVIFEHIYPATGKPNGTVTLAGAAEIDRAVEAARAAQGEWISMTVDRRRDLMIDLADIVHDHLDELARLNVFDYGVPISFAGTALLLERFLRHFAGYADKPHGVSTPVNGSFDVNLIEREPYGIIGVITPWNGALAVAASCVAPALAAGNAVILKPSELAPFAALRFGELCDRAGLPTGLVSVAPADAEGGDALVRHPGIGKIAFTGGGATARKVLAAAAANLTPVVTELGGKSANIIFDDADLDLAATLSAHQGPLMQSGQSCACASRILVQEAVYDAFVDKFVGVVAGARVGDPMDPATTFGPVISQAAADRILDTIETAVSNGTGQLLLGGNRIGGDLADGYYIEPTVFGGVDNASTLAQEETFGPVVSVMRFRDEQEAVQIANSTRYGLNAFVQTTDLGRAHRVARRLEAGSVWINQFSDISPQGPYGGYKQSGSGRTGGVEGLNEFRQVKNIRIGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PME6</accession>
    <name>A0A132PME6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23510">
        <property type="protein sequence ID" value="KWX23510"/>
        <property type="gene ID" value="AFM11_14670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7043"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="97" mass="8745" checksum="132B10EE27A4A3FB" modified="2016-06-08" version="1">MSSGLTAVPVGMAAFATANATAGEVISAAGSADSAAMLAAAATAIGPIGATYLAAYGRAQATNLAGTLLVGGVHAGIGGVTSGASAGLSSADSGFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMJ2</accession>
    <name>A0A132PMJ2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">NAD(P) transhydrogenase subunit beta</fullName>
            <ecNumber evidence="6 15">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nicotinamide nucleotide transhydrogenase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pntB</name>
        <name evidence="18" type="ORF">AFM11_14075</name>
        <name evidence="19" type="ORF">AWC31_09405</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="6 15"/>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849703.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09405"/>
    <dbReference type="EnsemblBacteria" id="KWX23417">
        <property type="protein sequence ID" value="KWX23417"/>
        <property type="gene ID" value="AFM11_14075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09159">
        <property type="protein sequence ID" value="ORX09159"/>
        <property type="gene ID" value="AWC31_09405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6919"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:NAD(P)+ transhydrogenase (AB-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012136">
        <property type="entry name" value="NADH_DH_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000204">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB" evidence="17">
        <location>
            <begin position="9"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KWX23417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX09159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="478" mass="49816" checksum="EA41C057BB9B1B76" modified="2016-06-08" version="1">MFTLENIATAAYVVAALLFILALAGLSKHETSRAGNTFGIAGMAVALVATVALALERKIEPLGLALLIVAMIVGAAIGLWRAKVVEMTGMPELIALLHSFVGLAAVLVGWNGYLHVEGDPAGAEAAHLAGEGMIGIHSAEVFVGVFIGAVTFTGSIVANLKLSARIKSAPLMLPGKNILNVGALVAFFVLTVWFVIDPQLWLLVVVTVLALLLGWHLVASIGGGDMPVVVSMLNSYSGWAAAASGFLLGNDLLIITGALVGSSGAYLSYIMCKAMNRSFISVIAGGFGIEAGPADDKDYGEHREITAEGAAELLSSASSVVITPGYGMAVAQAQYGVAELTRKLRDRGVNVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFADTDVVLVIGANDTVNPAAAEDPGSPIAGMPVLTVWNAANVIVFKRSMASGYAGVQNPLFFRENTQMLFGDAKDRVDAINNALSAVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMM2</accession>
    <name>A0A132PMM2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23447">
        <property type="protein sequence ID" value="KWX23447"/>
        <property type="gene ID" value="AFM11_14260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6959"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="741" mass="75860" checksum="A1E1BB4F4CFA67AF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMX0</accession>
    <name>A0A132PMX0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23614">
        <property type="protein sequence ID" value="KWX23614"/>
        <property type="gene ID" value="AFM11_14970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7105"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="166" mass="16850" checksum="09B2DF7DC2A419FB" modified="2016-06-08" version="1">MQPASPSGGTAITAIVLAGLGTLANLGGGLLGLIGLIALSNDSAFESVSDVSGGVFAVLILGVFASIVAGLLLLGGTITLMQRKMIGRWLVVSGCAITMLGSLLNLGLSAAVMARYETYGGGNGYAVLGLIFPIATLVLVLLPSTTAWIQAKRNPVVPQYYPPYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMZ6</accession>
    <name>A0A132PMZ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03130"/>
    <dbReference type="EnsemblBacteria" id="KWX23673">
        <property type="protein sequence ID" value="KWX23673"/>
        <property type="gene ID" value="AFM11_12810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6654"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="458" mass="49753" checksum="CB2B94F1D9D926A6" modified="2016-06-08" version="1">MAPVPDVSTLPLAPRNPLSIRQLANAVRALDTGQELIRAAGGPVTRVQLGPKWLVPPLVAVFSPEGIRDVLGRNDAFAERCIVHDEVRHAAGDSLFVLPNEQWRPRKRALQPVFTKQNVRAFGGHMSGAAQTAVDSWADGGDIDLDAECRRVTMQSLGRSVLGIDLNERAGVIVEHMHVASSYATDRALRPVRAPRWLPTPARKRARAAVAAMRGVAAEILHACRVDETHDAPLVRALMAATDPETGLAISDEDICNDLLIFMLAGHDTTATALTYALWALGHHPEVQDRVAAEATALGDRELTPADVPSLRYTVQVLDEALRMCPPAAGVGRLALQDMAVGGYRIEAGSLVALGIYAVHHDPEVWPNPQVFDPDRFSPENSLGRDRWHFIPFAGGSRSCIGEHFARLETTLALATIIRSVEVVSTDADFPVDVPFTTVARGPIRARVRARKPNHYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN01</accession>
    <name>A0A132PN01_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849223.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03380"/>
    <dbReference type="EnsemblBacteria" id="KWX23718">
        <property type="protein sequence ID" value="KWX23718"/>
        <property type="gene ID" value="AFM11_13095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6712"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="298" mass="31228" checksum="E91B0D8B236C1198" modified="2016-06-08" version="1">MTDPWARPTDQAPPAPPASPQQLPPQGPAPDYPAAPPPAAPTQKDSSAMAKIKKLLSDPLSIVLVVVIVLALVAAGLLGGELYARNRADTVVAGVVECIVEDSATASFDPLPPFLLQHMSGHYTNINIETAGNQIRDAKGMKVALHVKDVRLEDTADSGGSVGSLVANITWSTDGIRQTVADMVQLPFIGSAISDVSTNPSAGTIELKGLVGTIIAKPRVVNKGISLQITELNAIGLSWPRETLQPILDQFTSQLTENYPMGIHADSVQVTDSGVVAQFSTQNASMPKAAEDPCFAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN39</accession>
    <name>A0A132PN39_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849796.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18475"/>
    <dbReference type="EnsemblBacteria" id="KWX23462">
        <property type="protein sequence ID" value="KWX23462"/>
        <property type="gene ID" value="AFM11_14345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6977"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="27016" checksum="5CE008F93239F90F" modified="2016-06-08" version="1">MTDAEFDLATGEFDIGLVRAGAAAAARRRELDISQRSLAADGIINAGALIAFEKGRSWPRERTRLKLEEVLRWPPGTIARLRQGGSVPAPTAPVAPPSPPPAATTDTMISVPGTDEVPLIAQAVLTAVNTLESTVPTLPAEDDPEFTPRVTAMLADLRQLEAVASRAARISMVTPALIKALSAVRRQIDELTTRAAAAPGATLGQRLYAARRHANLTVGETAQAAGVSEDAIARAEAEYPVDAAAVHAIEAVIKTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNK8</accession>
    <name>A0A132PNK8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849555.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02910"/>
    <dbReference type="EnsemblBacteria" id="KWX23854">
        <property type="protein sequence ID" value="KWX23854"/>
        <property type="gene ID" value="AFM11_12630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6616"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="451" mass="48115" checksum="1279DAAE5DF2AC7C" modified="2016-06-08" version="1">MQIGRRETVAVAVGGTLVVAAFVVPHLDLGIVTPLINSTPGQIYSFADTAPIFGWWNTHVGWGTVPAVLIGAATVWWGQTVAQRLPWRTLTLATWATSCAWAFSLAMIDGWQRGFAGRLTARHEYLRQVPTVTDIPAAVRTFSSRILDFQPDSWITHVSGHPPGALLTFVWLDRIGLGGGAWSGLLCLLVGSSAAAAIIVAVRALADEHTARLAAPFVAVAPTAIWIAVSADGYFAGVAAWGIALLALAVSGSTRWTTLTAVGSGLLLGWGIFLNYGLVLMALPALAVLVTAADWRAALRVLIPAVLAALAVVAVFVVAGFWWFDGYTLVQERYWQGIANDRPFQYWSWANLASVVCAIGLGSVAGIGRVVDIAAIRRRSGPVVLLIGALLAIAFADLSMLSKAETERIWLPFTIWLTAAGALLPPRSHRGWLALNVIGALVLNHVILTNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNU7</accession>
    <name>A0A132PNU7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848370.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30340"/>
    <dbReference type="EnsemblBacteria" id="KWX24019">
        <property type="protein sequence ID" value="KWX24019"/>
        <property type="gene ID" value="AFM11_11685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6414"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453451" evidence="1">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="28174" checksum="AC1792098F6F44B2" modified="2016-06-08" version="1">MCRLLGVVSTTPISVSDAVGAHVLKDFVALTRVHGDGWGIARVEQAGGVPGVEVSAGSALDDPAFDSAVRRPPALASMVHLRWATNGLAVEPQNSHPFAVGGIAMAHNGSIKPADPLDDMLEPDIAASLRGTTDSERYFGVIRQHRRTAPDLAEAVRRAVAQLRPIYREASLNALVLGEGQLIAVHAHAHSFLPDEDVEEITAAELPTEHLEDYFALRWARPADGTLVVGSTGFGDLDWQPLPPESVTAISMSDLSMTSLPVMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP34</accession>
    <name>A0A132PP34_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11985</name>
        <name evidence="4" type="ORF">AWC31_09990</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848538.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09990"/>
    <dbReference type="EnsemblBacteria" id="KWX24075">
        <property type="protein sequence ID" value="KWX24075"/>
        <property type="gene ID" value="AFM11_11985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09260">
        <property type="protein sequence ID" value="ORX09260"/>
        <property type="gene ID" value="AWC31_09990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6476"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044870">
        <property type="entry name" value="BMC_CP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51931">
        <property type="entry name" value="BMC_CP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC circularly permuted" evidence="2">
        <location>
            <begin position="3"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="BMC circularly permuted" evidence="2">
        <location>
            <begin position="105"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="203" mass="21656" checksum="1FEECEE652C48731" modified="2016-06-08" version="1">MAQLRSFIFIDRLQPQTMSYLGTWIKGALPRADMAAQIIEVAPGLDIEGVTDVALKHAEVKAGILVVERQFGYLEFHGETGAVKAAADAALDFLGGDPDAAVRPTVLASRIISSIDHQHAFLINRNKIGSMVLPGESLFVLEVQPASYAILATNEAEKAADIKVVDFRMIGATGRVYLSGAEADVRQAAEAAQDALAVLQGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP45</accession>
    <name>A0A132PP45_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_12035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848871.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09940"/>
    <dbReference type="EnsemblBacteria" id="KWX24085">
        <property type="protein sequence ID" value="KWX24085"/>
        <property type="gene ID" value="AFM11_12035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6486"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="99"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="352" mass="37429" checksum="3A96BB220FCC3AE0" modified="2016-06-08" version="1">MTTAAVSVDDSLGTSTGKRIEHRRRSVEAIALATGSRVVVRNAVRMWALQPGLGWPLASIDRMVGLIPRRIGATVEPVALPTCRAEFVRASGASDRRAILYLHGGAFMTCGLNTHRGLVARLSKAADAAVLNVGYRMLPAWGLAEAIDDALAGLRWLRRRGYDSRQVVIAGDSAGGYLALATALRLIARGVEPAAGVAVISPLTDLDPARKLAHRNARRCSMFTGAALSAFARYLHQCEQGLVRDRDAQAVVNPAAADLKNMPPVAVHVSGDESLLADSELLADRLADANVRCDLHVWNGQIHDFPLAADVLPEGRRAIRYLGDFVREVTPTGGHVASSLSGRGQGYSAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP93</accession>
    <name>A0A132PP93_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_12425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848792.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09555"/>
    <dbReference type="EnsemblBacteria" id="KWX24150">
        <property type="protein sequence ID" value="KWX24150"/>
        <property type="gene ID" value="AFM11_12425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6564"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="322" mass="35154" checksum="66EF32848D0B301C" modified="2016-06-08" version="1">MTAVLDSTDVETVNDTPDVPLASWWSRAGAFAIDVVPGLAGIATLALLAFAAPLYGWLWWGSFVAAVLVTIAVLVNRVLWPATKGWSVGRAVFGIRVVTRDDGKAGLVRLLLRDLAHLLDTAAVFIGWLWPLWDKRKRTFADLLTRTEVHRVETPEQDARRRAGVLLVSAALVCVVAAGVGYLAVYRQDQAVRQAHEQIANDGPRIVEQLLSYGVDSFDQDFARAQSLATDNYRPQVIAQQDAVRKAGPTTNEYWAVSSAVLSATKSEASMLLAMQGQRGTNPQDLKFITATVRADFRKTGDAWQVDNLTVLKKPQMNGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPG3</accession>
    <name>A0A132PPG3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09885"/>
    <dbReference type="EnsemblBacteria" id="KWX24183">
        <property type="protein sequence ID" value="KWX24183"/>
        <property type="gene ID" value="AFM11_12090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6497"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="297" mass="31539" checksum="91E9686BBC4DFD00" modified="2016-06-08" version="1">MELPGGIRVSVETPDEGATFTLTESAADDRMTVTVDSVEHTLAELTERCGRWPQAAAVCDDVLRSIDVAAPTFGGVITESLAYSTLQSGPEFARWLAERGPATVPELPDPVQARRDGNTLHVRFNRPRRHNAFSTDARAALLEALDVARLDQSVDEVVLGGNGRSFCSGGDLAEFGSFADPASAHLARTRHSPALLLDELTARLGRRCRAHVHGQVLGSGLEMAAYCGWVRCDPHATLGLPELALGLIPGAGGTVSITRRIGRWRTAFLVLSGRTIDAATALAWGLVDEIVSVGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPG7</accession>
    <name>A0A132PPG7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_09535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847153.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05690"/>
    <dbReference type="EnsemblBacteria" id="KWX24230">
        <property type="protein sequence ID" value="KWX24230"/>
        <property type="gene ID" value="AFM11_09535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5944"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="211" mass="23398" checksum="F3521D5D969507C0" modified="2016-06-08" version="1">MPSVTRKPQAKREERREEIERQLLAATDRLMADGTSFTELSVDKLATEAGISRASFYIYFEDKGHLLRRLATQVFGELARDAEQWWGVAGRRDPADVRAAMSGIIASYRRHQPLLVALNEMSAYDSLVGQTYHELLAGITAQLTRVIEDGQADGSIRPQLPAATTASALTWLVERTCHINLPSQPASYDAELAATLTQIVWAALYLESPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPM6</accession>
    <name>A0A132PPM6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848814.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31265"/>
    <dbReference type="EnsemblBacteria" id="KWX24157">
        <property type="protein sequence ID" value="KWX24157"/>
        <property type="gene ID" value="AFM11_10990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6274"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="467" mass="49283" checksum="5FA380C0C3F03384" modified="2016-06-08" version="1">MTAPAAPAAPVTTTPPVVPMGDFAPVAKLVNDAIAAHRLPGAVVQVGHSGNVVFRQAFGSRKLADEPGLDGAPAPAESMTADTIFDLASLTKSLTTATAIMQLYERGKIQIDERVQTYLPDFNPADDPRRAQVTLRMLLTHTSGIAGDLSLDGPWGLDKADKADGIRRALGAWVVFGPGELFHYSDINFIILGALIEKITGEPLEDYIRHNVFEPLGMNDTYYLPAAKACGPHQIRGTAIALDPGAPEVDECPPGTWNTELLTRVAPTAVDGDTPGLNPDFGHLLRGTVHDPTARRMGGISGSAGVFSTVHDVGLFAQALLDRLAGRPSAFPLTRSTLELMTTPQQPGHTAAQLEAANNAAREAIETSPNSTDPLLAPHYPAIAGQDLRGFGWDIDTAHSRPRGLIFPIGSFGHTGFTGVTLWIDPGSNTYVVVLANVIHQRGGPPIAGLSGEIATVTARALHLYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ48</accession>
    <name>A0A132PQ48_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase</fullName>
            <shortName evidence="2">3-HCI hydroxylase</shortName>
            <shortName evidence="2">3-HPP hydroxylase</shortName>
            <ecNumber evidence="2">1.14.13.127</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mhpA</name>
        <name evidence="5" type="ORF">AFM11_10930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:27846"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:47928"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58642"/>
            <dbReference type="EC" id="1.14.13.127"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24785"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46951"/>
            <dbReference type="ChEBI" id="CHEBI:57277"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.13.127"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aromatic compound metabolism; 3-phenylpropanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.127" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19445"/>
    <dbReference type="EnsemblBacteria" id="KWX24460">
        <property type="protein sequence ID" value="KWX24460"/>
        <property type="gene ID" value="AFM11_10930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6225"/>
    <dbReference type="UniPathway" id="UPA00714"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008688">
        <property type="term" value="F:3-(3-hydroxyphenyl)propionate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019622">
        <property type="term" value="P:3-(3-hydroxy)phenylpropionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019380">
        <property type="term" value="P:3-phenylpropionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01652">
        <property type="entry name" value="MhpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023786">
        <property type="entry name" value="3-HPP/3HCI_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="4">
        <location>
            <begin position="6"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="559" mass="60941" checksum="AAABFFF7C82734AF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQP7</accession>
    <name>A0A132PQP7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">moaA</name>
        <name evidence="15" type="ORF">AFM11_08060</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846262.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24660"/>
    <dbReference type="EnsemblBacteria" id="KWX24625">
        <property type="protein sequence ID" value="KWX24625"/>
        <property type="gene ID" value="AFM11_08060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5462"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="27"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="286"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX24625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="354" mass="37867" checksum="3C0394D5F1079CDD" modified="2016-06-08" version="1">MTVTALGLPTVARPTTDAPSTGPLIDTYGRVATDLRVSLTDRCNLRCTYCMPAEGLNWLPGDALLSPAELGRLLRIAVTRLGVTSVRFTGGEPLVTRHLEEVVAAAAALTPRPEITLTTNGLGLARRAAGLKQAGLDRINVSLDSVDAAHFARITRRDRLGDVLAGLAAAKAAGLDPVKVNAVLDPVSGLDDAVELLRYCLAHGYQLRIIEQMPLDAGHNWQRSEVIDAERILQTLRHHFDLRPDPKPRGSAPAELWQVLDSAGQVTGTVGVIASVSQAFCSACDRTRLTADGQIRSCLFSREETDLRALLRGDAGDDEIEAAWRAAMWAKPAGHGINDPGFLQPDRPMSAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQU8</accession>
    <name>A0A132PQU8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846514.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24711">
        <property type="protein sequence ID" value="KWX24711"/>
        <property type="gene ID" value="AFM11_08570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5563"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453509" evidence="2">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="83" mass="8128" checksum="4EBAAED669F6717B" modified="2016-06-08" version="1">MRRIWMAAATLAAAAALASCSSGKPEPAPTSDAPAEHGSYAHCLSEHGVPAPPGPAAGAPPGVDPGVWQQAMQACSTLAPGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQW3</accession>
    <name>A0A132PQW3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine cleavage system protein T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_08580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846520.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13790"/>
    <dbReference type="EnsemblBacteria" id="KWX24713">
        <property type="protein sequence ID" value="KWX24713"/>
        <property type="gene ID" value="AFM11_08580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5565"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="4">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="355" mass="37725" checksum="3C22931A561B0666" modified="2016-06-08" version="1">MSAVPAPETGPDAGAVWHYGDPLGEQRAAADDAVLVDRSNRAVLTLTGKDRQTWLHSISTQHVSALPDGVVTENLSLDLQGRVEDHWLQTELGGTTYLDTEPWRGEPLLAYLRKMVFWADVQIEPADLGVLSLLGPGVAKDPVLKALGLTTLPDELTAAALPGGGFVRRLASPSTELDLIVPRNQIEAWQARLAEAGVRSAGVWAYEAHRVAARRPRLGLDTDERTIPHEVGWIGTAVHLDKGCYRGQETVARVHNLGKPPRMLVLLQLDGASERPATGDPVLAGGRTVGRLGTVVDHVDDGPIALALLKRGLPADTALVTGGAVEVSAAIDPDSMPPPDTAGAGRVAVERLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR21</accession>
    <name>A0A132PR21_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_08990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846721.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13380"/>
    <dbReference type="EnsemblBacteria" id="KWX24780">
        <property type="protein sequence ID" value="KWX24780"/>
        <property type="gene ID" value="AFM11_08990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5648"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="41"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="121"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="474" mass="50239" checksum="789B9098D15D82BB" modified="2016-06-08" version="1">MTQDNSVSSRSRWLRIGLAALLLVTLAVGVFQVWPSRVGHKLTAYFTNAVGLYPGDEVRVVGVPVGKIDSIEPRPSDVKITMTIDDGVKVPADAKALIIAPNLVSARFIQLTPAYTEGDVMAEGASIGLDRTGVPVEWDEVKEQLTQLSTQLGPQQGSVQGPLSQFVNQAADTFYGNGDSFRNALRELSQTAGRLGDSRADLFGTIRNLQVLVDALSNSNEQIVQFTNHVASVSQVLADSSSGLDSTLATLNQALSDVRGFLDESNDALIAQVGKLADFTQILTDHSDDIEQILHITPNGLANFYNIYNPAQGTVGGLLSLPNFANPVQFICGGTFDTGANPDNYKRAEICRQRMGPVLKRITMNYPPLLFHPINSITAYKGQIIYDTPETEAKSETPVPYLQWQNAPGVTPPQIPPDASLSSLILPPDPAAATPGAPALPPPTSSHMGGPEAPAPGPAPDPAAPLPPQAGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS36</accession>
    <name>A0A132PS36_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltooligosyl trehalose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845445.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28895"/>
    <dbReference type="EnsemblBacteria" id="KWX25115">
        <property type="protein sequence ID" value="KWX25115"/>
        <property type="gene ID" value="AFM11_06755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4550"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013797">
        <property type="entry name" value="Maltooligo_trehalose_synth_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="6"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="754" mass="81996" checksum="916374658F12137B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS47</accession>
    <name>A0A132PS47_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06810</name>
        <name evidence="3" type="ORF">AWC31_28840</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28840"/>
    <dbReference type="EnsemblBacteria" id="KWX25125">
        <property type="protein sequence ID" value="KWX25125"/>
        <property type="gene ID" value="AFM11_06810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13799">
        <property type="protein sequence ID" value="ORX13799"/>
        <property type="gene ID" value="AWC31_28840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4561"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021213">
        <property type="entry name" value="DUF2567"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10821">
        <property type="entry name" value="DUF2567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="223" mass="23153" checksum="4F1F28144C41EDCD" modified="2016-06-08" version="1">MSVSNETQNAAVTEPAEVTDGPRVSRLRAVMIVIAALAVAGALLGVLWAWLAPAIHGVVALTRSGERLRAYLGSESDHFFTAAFMFSGLLVVLAVVSAVALWQWRVHRGPVLVGALAAGCAAAAATAAGVGAVLVHWRYGTVDVAAAPVTPEHRVHYVVEAPPVFFGHTPLQIAATILFPAAIAALVYALLAVSTPRDDLGAWPPVETPPFPVLPPPVTPQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSF2</accession>
    <name>A0A132PSF2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845801.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11570"/>
    <dbReference type="EnsemblBacteria" id="KWX25240">
        <property type="protein sequence ID" value="KWX25240"/>
        <property type="gene ID" value="AFM11_05710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4333"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="193" mass="20878" checksum="892D2C45C721B3BD" modified="2016-06-08" version="1">MLLTRTTAEGIADGTITLVLRRWDAPRAKVGGTQRTVAGTIRIDDVAEFPGNYRVSAEQARSAGYPDAESAQAELDRRPAAHTYVISVSYLGPDERPDLAADDALDDAAVEAITARLDRWDAASADGPWTRRYLGMIAANEAVRAPDLAARVGLDVPRFKRRVRQLKGLGLTISLDVGYRVSPRGRAYLAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSG2</accession>
    <name>A0A132PSG2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843822.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25286">
        <property type="protein sequence ID" value="KWX25286"/>
        <property type="gene ID" value="AFM11_03045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2478"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453246" evidence="1">
        <location>
            <begin position="29"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="27528" checksum="32737CB255E7878B" modified="2016-06-08" version="1">MKTGLDAKIVLITGAASGIGAASARAFAAENAQLALLDRDEHGLQLLAKELSEQTTVHYRSTELSTEAGVVGGINDVLALYEGRVDVLFNNVGAGSLGTFDSLSDANWVNTLQLNFLSQVRASTAVLPAMRAAGRGVIVNNASDLGRQPISSGPDYAASKAAILSLTSSLALNEGPTIRVNAVAPGPIMSPMWTMQGGLADTFAAVHGVHRDDSIALEMKTRGMPLARIGTPEEVANVVVFLASDLASYVTGAVYGVDGGSFRSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSW2</accession>
    <name>A0A132PSW2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_04035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844333.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21120"/>
    <dbReference type="EnsemblBacteria" id="KWX25438">
        <property type="protein sequence ID" value="KWX25438"/>
        <property type="gene ID" value="AFM11_04035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2685"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="206"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="449" mass="48789" checksum="1C18E1BB31449B3D" modified="2016-06-08" version="1">MAELHPKLQAIFEEVTRRNAGETEFHQAVTEVLMSLGPVVAKHPEYADNAVIRRLCEPERQIIFRVPWHDDSGTVQINRGFRVEFNSALGPFKGGLRFHPSVYLGIVKFLGFEQIFKNSLTGLPIGGGKGGSDFDPKGRSDAEVMRFCQSFMTELYRHIGEYTDVPAGDIGVGMREIGYMFGQYKRITNRYESGVFTGKGLTWGGSQVRTEATGYGTVFFVDEILRATGQSFDGKRVVVSGSGNVAIYAIEKVHALGGIVVACSDSGGYVVDDKGIDLDILKEIKEVHRGRIDDYVEARGGTSQFVADRSVWEVPCDIALPCATQNEVSGTDAGLLIESGCRIVAEGANMPCTPEAVKLFDQAGVTFAPGKAVNAGGVATSALEMQQNASRDSWTFDETEERLAEIMRRIHDRCLSTADEYGQPGNYVAGANIAGFIRVADAMLALGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSZ5</accession>
    <name>A0A132PSZ5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843906.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25317">
        <property type="protein sequence ID" value="KWX25317"/>
        <property type="gene ID" value="AFM11_03245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2524"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="169" mass="18864" checksum="B3C819FBE7DBF281" modified="2016-06-08" version="1">MVGNPGFGEPGDLSGLDEAETQCWDQFFQSAWLFYETLNRELIGTHNLSLFDVQLLDLLAKSEGGSARMGDVAEALILQPSRVTEQIRRLESHGLVLRRASKRDRRGVVATVTREGRARLKPALVTYSRVVRTFYLGQMSRQQMIALGESSRRVAVGLKSRMAAKIGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT86</accession>
    <name>A0A132PT86_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844562.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20545"/>
    <dbReference type="EnsemblBacteria" id="KWX25525">
        <property type="protein sequence ID" value="KWX25525"/>
        <property type="gene ID" value="AFM11_04600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2799"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021417">
        <property type="entry name" value="DUF3060"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11259">
        <property type="entry name" value="DUF3060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="233" mass="24134" checksum="F79961F7625B0368" modified="2016-06-08" version="1">MCEHLRMDPQDDPEARIRELERPLADVARASELGTGHDVSPTQPWTHGNTFPPPPPGPPAPWPGYADQFAPPPPQPHSGSGARILVVLGLIMVSLFAAGIAAYVMFSGSGGDTSTDETASPPNPTVQAPVIAPPRVTTDSTTVTAPGETVIVSGVNENRTVACNGNAVIVSGIENTLTITGHCANIAVSGIQNTITVDSADTIGVSGFENRVTFHTGQPEISKSGQDNSVEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT89</accession>
    <name>A0A132PT89_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nanE</name>
        <name evidence="6" type="ORF">AFM11_04640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NanE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844578.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20505"/>
    <dbReference type="EnsemblBacteria" id="KWX25533">
        <property type="protein sequence ID" value="KWX25533"/>
        <property type="gene ID" value="AFM11_04640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2807"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="226" mass="23500" checksum="BC59DA97E7FB0E4B" modified="2016-06-08" version="1">MTDVIDALAGGLIVSCQAYPGEPLRQPDTMARMADAVVAGGAVSIRAQGVDDISTIKSRTTVPLIGLWKEGTDGVFITPTLRHATAVREAGADIVALDGTRRARPDGLTLTATITRLRDSAPTVVMADCASLDDALAARDAGADIIGTTLAGYTDYRPMTDGPDLDLLAQLVSRLPDVPIIAEGRVHTPAQARAALDTGAYAVVVGTAITHPTTITGWFRQALIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTQ8</accession>
    <name>A0A132PTQ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844904.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25695">
        <property type="protein sequence ID" value="KWX25695"/>
        <property type="gene ID" value="AFM11_04255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2728"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="235" mass="22887" checksum="C36792E912C47F2F" modified="2016-06-08" version="1">MLTALLWGLVAASSLVIGAVAGVVRDWNRRFVGLVLGFGAGALISSISFELAEEGFRASGALAVAVGLAVGAVVFYVADTAVDRMGASNGAQTAGLPLLLGALLDGIPEQAVLGIGIAGGAGVSLALVVAIFVSNLPESIGSASDMKSAGHSVSRIVGGWTAIAAVCALATVGGYQLQKVAGGALQGGINGFAAGALLVMLVGSMIPEATEKARENAGLAAVLGFAVAAGLSLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTT6</accession>
    <name>A0A132PTT6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844732.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20150"/>
    <dbReference type="EnsemblBacteria" id="KWX25607">
        <property type="protein sequence ID" value="KWX25607"/>
        <property type="gene ID" value="AFM11_05080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2897"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="514" mass="58042" checksum="1D998B80E6949502" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTZ6</accession>
    <name>A0A132PTZ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase-modifying factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842199.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33470"/>
    <dbReference type="EnsemblBacteria" id="KWX25783">
        <property type="protein sequence ID" value="KWX25783"/>
        <property type="gene ID" value="AFM11_00355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.72"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="32138" checksum="437920A6521463E6" modified="2016-06-08" version="1">MLTELVEVPGGSFRMGSTSFYPEEAPIHTATVADFAIEKHPVTNAQFAEFVDATGYRTVAERPLDPALYPGVADEDLQPGSLVFRPTPGPVDLRDWRQWWDWAPGASWRHPFGPQRAECRPDHPVVQVAYPDAVAYAAWAGRRLATEAEWEYAARGGVEGVYAWGDEVTPDGRLMANTWQGRFPYRNDGALGWTGTSPVGTFPPNALGLFDMIGNVWEWTTTRFAPHHRPDAAQSGCCPSPSGDPGVNQVLKGGSHLCAPEYCHRYRPAARSPQSQDSSTTHIGFRCVADALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU81</accession>
    <name>A0A132PU81_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842525.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34010"/>
    <dbReference type="EnsemblBacteria" id="KWX25896">
        <property type="protein sequence ID" value="KWX25896"/>
        <property type="gene ID" value="AFM11_00980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.202"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003207">
        <property type="entry name" value="Ppandiol/glycerol_DeHydtase_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036091">
        <property type="entry name" value="Prodiol/glycerol_DeHase__sf_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02287">
        <property type="entry name" value="Dehydratase_SU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47148">
        <property type="entry name" value="SSF47148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="142" mass="15557" checksum="DCDDA5361DF45095" modified="2016-06-08" version="1">MTEPILDPSVDYPLSLNRKDLLFTPNGKPIDGITMDAVMSGDVEASDLRITPQTLRLQAQIAEKVGRKQLGANLRRAAEMTAISDERVLQIYNALRPNASTKAVLDSIADELETQYGATLLAGLVREAADVYERRDILATSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUI9</accession>
    <name>A0A132PUI9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="2">HAT</shortName>
            <ecNumber evidence="2">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Homoserine transacetylase</fullName>
            <shortName evidence="2">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">metXA</name>
        <name evidence="5" type="ORF">AFM11_01850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842954.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34630"/>
    <dbReference type="EnsemblBacteria" id="KWX26018">
        <property type="protein sequence ID" value="KWX26018"/>
        <property type="gene ID" value="AFM11_01850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.380"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="55"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2 3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="376" mass="39577" checksum="F2B9E8E90A2CD93C" modified="2016-06-08" version="1">MTITEEPPVQTQPLPAEGEIGLVNIGALTLENGTVLPDVTIAVQRWGELSPNRDNVVVVLHALTGDSHVTGPADDDHPTPGWWDGVAGPDAPIDTDHWCAIATNVLGGCRGSTGPGCLAPDGKPWGSRFPQITIRDQVAADRAALAALGITEVAAVIGGSMGGARALEWIVGHPDDVRAALVLAVGARATADQIGTQATQVAAIKADPDWQGGDYYGTGRAPTAGMEIARRFAHLTYRGEEELDTRFRNEAQGGEDPVAGGRYAVQSYLEYQGGKLAARFDPGTYVVLSDALSSHDVGRGRGGVRAALRSCPVPTVVGGITSDRLYPIRLQEELADLLPGCSDLDVVDSAYGHDGFLVETELVGKLIRRTLELAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUJ4</accession>
    <name>A0A132PUJ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842858.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25990">
        <property type="protein sequence ID" value="KWX25990"/>
        <property type="gene ID" value="AFM11_01625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.335"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="69" mass="6970" checksum="745E53222148C974" modified="2016-06-08" version="1">MTTTTYHVTGMTCGHCEGAITREVGQVAGVQRIEVSATTGILAVTSAGELDDAAVLAAVEEAGYTGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUR9</accession>
    <name>A0A132PUR9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_02290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843184.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35070"/>
    <dbReference type="EnsemblBacteria" id="KWX26091">
        <property type="protein sequence ID" value="KWX26091"/>
        <property type="gene ID" value="AFM11_02290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.469"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="46"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX26091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="361" mass="38489" checksum="99FB4F8879270B1F" modified="2016-06-08" version="1">MFTQTLTEGVGRRLLASRRVSALANLLTGPHGVDRYTELVEPTWTRRDARAKVVAVRRQTPRSVTLTLEPNEAFAGFRAGQHINLSVEINGRRRTRCYSPASAEGARYIELTIGRHDGGLVSNYLCDHAYPGMVLGLDAVGGDFVMPEALPRRILFVSGGSGITPVMSMLRTLRAQAFTGDISFVHYARAADEACYRDELAATRGVRVLHGYTRSTDESDLDGHFGPAHLAAACPDAEPDAVFVCGPPALVDAVREHCRNVSSESFVPPTFAVPAASTGGTVRFSTSGVDVVDDGRPLLVQAEAAGLTPESGCRMGICHSCTRFKSSGAVRNLITGAVSSADCEDIQICVTAPVGDVAIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUS1</accession>
    <name>A0A132PUS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_02135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843093.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26065">
        <property type="protein sequence ID" value="KWX26065"/>
        <property type="gene ID" value="AFM11_02135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.438"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="246"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="360" mass="36161" checksum="F0BF170E62A0263D" modified="2016-06-08" version="1">MPSALVSALAAPLHEVRALVGPGWPVGATPVTTLDAARTALADIGSAAGRSWTQAETGWSGAAADAAADIATTTTDTIAALAERAEALSVSAQQAGGAVSSAGDRLQAIVDRFEDRAAELEPHLEEPGVAEELLAEAQRSLREAIAVIDELRAELDRQAVAVMPAGAPAPTVPAGFSGGSSGTSLGMSRGMSPGMLSSGWSGGSTGSPASSLPAPGEVASALRDPGLFGDGVAVRLPDGSSALAPNSVAASAVRHALTQLGVPYHWGGTTPGVGLDCSGLTQWAYREAGLNIPRLAQEQDIGAAVSADALRPGDLAVWDGHVAMVVSANTMIEAGDPVQLSPIRTTNAGQGFQGFWRPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUV7</accession>
    <name>A0A132PUV7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="13" type="ORF">AFM11_00505</name>
        <name evidence="14" type="ORF">AWC31_33620</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842272.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33620"/>
    <dbReference type="EnsemblBacteria" id="KWX25812">
        <property type="protein sequence ID" value="KWX25812"/>
        <property type="gene ID" value="AFM11_00505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11626">
        <property type="protein sequence ID" value="ORX11626"/>
        <property type="gene ID" value="AWC31_33620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.104"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX25812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX11626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="441" mass="47678" checksum="2CF5DBA992971D83" modified="2016-06-08" version="1">MLSAFISSLRTADLRRKILFTLGVVILYRVGASIPSPGVNYPNVQKCIEQVSGGDSAQIYSLINLFSGGALLQLTVFAVGVMPYITASIIVQLLTVVIPRFEQLRKEGQAGQAKMTQYTRYLSIALAILQATSIVALAANGGLLQGCSLDIIQDSSIFGLIVIVMVMTAGAALVMWMGELVTERGIGNGMSLLIFAGIAARIPSEGQTILESRGGVVFTAVCVAALIIIIGVVFVEQGQRRIPVQYAKRMVGRKMYGGTSTYLPLKVNQAGVIPVIFASSLIYIPHLITQLIQSGSSNPGTGWWDKFVADYLTNPADPVYIAIYFGLIVFFTYFYVSITFNPDERADEMKKFGGFIPGIRPGKPTADYLRYVLSRITLPGSIYLGVIAVLPNLFLEIGNTGSVQNLPFGGTAVLIMIGVGLDTVKQIESQLMQRNYEGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV02</accession>
    <name>A0A132PV02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_02360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843224.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35140"/>
    <dbReference type="EnsemblBacteria" id="KWX26104">
        <property type="protein sequence ID" value="KWX26104"/>
        <property type="gene ID" value="AFM11_02360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.484"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX26104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="246" mass="26358" checksum="A319D1FFFD2D98DC" modified="2016-06-08" version="1">MSAENTGTVEVHREDTVAVVTLRRERKRNALSTHMESELLRALRSPEVESSRAIVITGGDTVFSAGADVTELREMTPHAIADYYRGSGSVYEVFAGLPQPTIAAITGYCLGGGLELSLAADIRIADPAAVFGFPEIGIGILPSSGGVTRMVRVVGAGRTRDLVLRGRRFDAGQAELWGIVSEVTAPGEHIKKAMEIARELAERPPLALRITKQVLDVSLDAPTQAALLLEQLAYAVLNNAPEKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV97</accession>
    <name>A0A132PV97_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26256">
        <property type="protein sequence ID" value="KWX26256"/>
        <property type="gene ID" value="AFM11_01655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.341"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="200" mass="21582" checksum="4BB8621CEF2F4D51" modified="2016-06-08" version="1">MHDLYVRNTFGIIDRLGLDTVSVVGVSTGGTVALGMAMTAPERVERLVVGGCTASTGGDPYLLATAPTEVGRLFDECQSGPPDRRRIARLLRSLVVDPGLIDDDLVERCYRWRVDKPDHAAAWARSTIVARSNLAALGAVAVPALVVHGRHDRMVPLEGALQLISHLPSADLVVLNNCGHWPPYERPHSFAKVVEGFLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVE1</accession>
    <name>A0A132PVE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01475</name>
        <name evidence="3" type="ORF">AWC31_34445</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843624.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34445"/>
    <dbReference type="EnsemblBacteria" id="KWX26244">
        <property type="protein sequence ID" value="KWX26244"/>
        <property type="gene ID" value="AFM11_01475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12118">
        <property type="protein sequence ID" value="ORX12118"/>
        <property type="gene ID" value="AWC31_34445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.302"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX12118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="284" mass="31518" checksum="D62BE3A687E3C0BB" modified="2016-06-08" version="1">MDKREFGAFLRSRRERISPTDVGLPVGARRRTPGLRRDEVAHLAFISTEYYTRLEQARAPHPSREVLAGLTRALRLSDAERAHLYVLAGVEPEAPLGPPRAVRQSILDLLQRLPQAAAIVLSATYEVIAWNDLACALMEDFSALSRRDRNLVRRAFLGPRPPGGRRLYGVSDADEFGRTCTQHLRATAARYPDDPETAELIAELRAGSEEFRQLWDAHDVIAQPALCKTFAHPVVGPVAVNCDVLDIADRDQRVVIYTPEPGSPSEEAMRLLAVLGTQRMDVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PW18</accession>
    <name>A0A132PW18_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_00325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843559.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33435"/>
    <dbReference type="EnsemblBacteria" id="KWX26212">
        <property type="protein sequence ID" value="KWX26212"/>
        <property type="gene ID" value="AFM11_00325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.66"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018741">
        <property type="term" value="F:alkyl sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018909">
        <property type="term" value="P:dodecyl sulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07710">
        <property type="entry name" value="arylsulfatase_Sdsa1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044097">
        <property type="entry name" value="Bds1/SdsA1_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="5">
        <location>
            <begin position="109"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX26212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="637" mass="71129" checksum="E68FF85DC2EF51F9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-02-10" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAS0</accession>
    <name>A0A132PAS0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000060">
        <property type="protein sequence ID" value="KWX19418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067860046.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19418">
        <property type="protein sequence ID" value="KWX19418"/>
        <property type="gene ID" value="AFM11_35975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6572"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="142"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="425" mass="46301" checksum="81B490A4A5DB273B" modified="2016-06-08" version="1">MAVNEPIDPRVRLAISQWPDDAPRGAVSTFCAEHGISRKSFYELRKRVKTDGPAAVLEPRTRRPKSSPSALTDEVKQQAVAVRAALEASGLDHGPISVHDKMGALGLGPVPSVASLARIFRREGVAKAEPKKKPRSAWRRFVYPAPNACWQLDATGYVLTGGRQCVIFQLIDDHSRYAVASHVACSETAEAAIAVFDKAVAAHGVPQRLLSDNGIALNPSRRGYLGKLVEHVSRLGVEAITGKPYKPTTQGKNERFHQTLFRYLDKQPLANTLAELQAQVDAFDDIYNTERPHQGLPGRVTPRTAWESTAKVPAPRPKHDLPWFVPLAPKPKRPAPQPQDLPAGTHIMTLSTAGTVRLAGVTYKVDGRLACQQVLVVTNAESIIVADLDGEVLIEHTRPQAGVKYVGNGRPRGQRPKSDETSPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB09</accession>
    <name>A0A132PB09_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease</fullName>
            <ecNumber evidence="3">3.5.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859841.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02645"/>
    <dbReference type="EnsemblBacteria" id="KWX19496">
        <property type="protein sequence ID" value="KWX19496"/>
        <property type="gene ID" value="AFM11_35605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5857"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="216" mass="23099" checksum="5489E6B6B6190429" modified="2016-06-08" version="1">MNLTPTELERLTIFTAAELARRNLREGIPLSHPEAVAFLTDEAMLAARKNMAYDEVIDHVTGLLDADQCEPGVPDMVRIVMLDAPFADGTKLVTLIDPIVARGGDARPGEIIVGDEPIELFPGAQRVTLTVVNRGDRDIQVRSQSHFCEANAALEFDRRAAWGHKLAVASGAGVRFEPGIPVEVTLVPMAGDRIIHGFSGSADGPLDADGALEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB36</accession>
    <name>A0A132PB36_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aromatic-ring-hydroxylating dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_35335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000043">
        <property type="protein sequence ID" value="KWX19526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040736.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19526">
        <property type="protein sequence ID" value="KWX19526"/>
        <property type="gene ID" value="AFM11_35335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5798"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08881">
        <property type="entry name" value="RHO_alpha_C_NDO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043266">
        <property type="entry name" value="RHO_NdoB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="5 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="11">
        <location>
            <begin position="39"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX19526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="487" mass="55167" checksum="024BD9DDB7851D26" modified="2016-06-08" version="1">MTDHSGVIQDVRQGMIPAHIYNDKEIFELEKERVFGRSWLFVAHESEVPEAGDYVVRRVLEDSFIISRDEHGEIRALFNMCLHRGMQVCRTEMGNASHFRCPYHGWSYRNDGRIVGLPFHKEAYGGEEGFKKQGQTLLPAPSLGIYNGLIFVSLDPDAEPLEDFLGDFKFYMDYYTKQSSGGIELRGPQRWRVKANWKIGAENFAGDMYHTPQTHTSVVEIGLFREPKAEKRKDGTTYWAGNGGGTTYKLPEGSLEDRLRYVGYPDEMIARMKEQWSQEQLDVVGKDGFMVSAASVFPNMSFVHNWPRVEEDSDEVLPFISIRQWQPISEDETEIVSWFAVDKNAPEEFKALSYKAYLMCFGSGGMFEQDDVENWVSLTSTAGGPMARRLLLNSRMGMLENGQNVVEPLTPEQYSGPGSTRVGYSEYNQRELLLRWANHLERPMEKAAQVHVGSNPVQDCPSDTPDSFPAPAEHNGHAPAMTVSKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBH9</accession>
    <name>A0A132PBH9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17285"/>
    <dbReference type="EnsemblBacteria" id="KWX19654">
        <property type="protein sequence ID" value="KWX19654"/>
        <property type="gene ID" value="AFM11_34510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5247"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="12"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="143"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="354" mass="36841" checksum="E6AA0CA48B78FD39" modified="2016-06-08" version="1">MTFWRETVTEQLRAGVIGAGFIGAVHANAVRAAGGVVTRVAASTPERSAEAAHRLGALGSAATAEELIDSDDVEVVHICTPNSLHVPLARRALAAGKPVICEKPLATTLSDASSLAAEAKGRVATVPFVYRFYPAIREAWARIAAGEAGPLHLLHGAYLQDWQAGGASAGWRGEDTEGGAYRAFADIGVHWCDLVEFTTGHRITRLLARTTANGTVTTVLFDTDAGAAGSMLASQTAIGRRNALRISLDGADAAYGFDQENPENLFVGGMDGNLTLHRGSPATSAATARYSLLPPGHPQGYQDCFNAFVADTYAAIDGSAPDGLPTFADGLRAAALVDAVITSSQSATWVEVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBJ2</accession>
    <name>A0A132PBJ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Limonene-1,2-epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859448.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10875"/>
    <dbReference type="EnsemblBacteria" id="KWX19617">
        <property type="protein sequence ID" value="KWX19617"/>
        <property type="gene ID" value="AFM11_34730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5293"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="147" mass="16533" checksum="5DDAC5F62CD772EC" modified="2016-06-08" version="1">MSVEDTILGMWKALSGRDWDLLKTYLAEDCIYLDMPVGPAAAAKGPEDIVKRLKIGLEPLASYENFDGLLIAAGQDAMYEHHEEWHWQTGESAVLKFVSVHRVEDGKITLWKDYWDMGALANHAPPTWMADFANADMSWVYDATGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBN2</accession>
    <name>A0A132PBN2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">engA</name>
        <name evidence="7" type="synonym">der</name>
        <name evidence="11" type="ORF">AFM11_34385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859228.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11285"/>
    <dbReference type="EnsemblBacteria" id="KWX19730">
        <property type="protein sequence ID" value="KWX19730"/>
        <property type="gene ID" value="AFM11_34385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5221"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="31"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="204"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="84"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="210"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="257"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="322"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX19730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="466" mass="50640" checksum="C4E8D3E046249572" modified="2016-06-08" version="1">MSEDGTWSDESEWELPADVIEAVEEAAIAPPVVAVVGRPNVGKSTLVNRILGRREAVVQDIPGVTRDRVSYDANWLGRRFVVQDTGGWEPDAKGLQQLVADQASVAMRTADAIILVVDAVVGATAADEAAARLLRKSGKPVFLAANKVDTERGEADAAALWSLGVGEPHPISAMHGRGVADLLDRLIEDLPETSELAGGGGGPRRVALVGKPNVGKSSLLNRLAGDERSVVHDVAGTTVDPVDSLIELGGKTWRFVDTAGLRRKVGQASGHEFYASVRTHGAIDAAEVVMVLIDGSQPLTEQDQRVLSMVIEAGRALVLVFNKWDLVDEDRRYLLDREIERELVQVQWAPRVNISAKTGRAVQKLVPALETALASWDTRIPTGRLNTFLKEVVAATPPPVRGGKQPRILFATQATSRPPTFVLFTSGFLEAGYRRFLERRLRETFGFEGSPIRINVRVREKRSAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC08</accession>
    <name>A0A132PC08_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000044">
        <property type="protein sequence ID" value="KWX19522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040871.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19522">
        <property type="protein sequence ID" value="KWX19522"/>
        <property type="gene ID" value="AFM11_35520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5838"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="162" mass="18176" checksum="D2D4B706C972AD14" modified="2016-06-08" version="1">MTLSRDELADFAESMARAGDRDTQHVTEEHLVVNSTEAHWIQTGSPSEIGLLLRIPARSIEFFLQKIPAGAGSDLHRHVHESVHFVRHGSGWSEIGDQRVTWSAGDFVYTPPWVWHRHYADDQQDVEMIVIENSRLLAAVDATQRETRGNVSFAEAFGVGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC20</accession>
    <name>A0A132PC20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000043">
        <property type="protein sequence ID" value="KWX19532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19532">
        <property type="protein sequence ID" value="KWX19532"/>
        <property type="gene ID" value="AFM11_35375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5806"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="146" mass="15692" checksum="C6FDDDB1D7645FF6" modified="2016-06-08" version="1">MGERAAMNGQQSDLSGAPAGSVFSMVCPAARQAGCSLRTAALGAAPGRNGLKESLTECEIEVFLSLARGHRIAVRDHETGALWYGRVDMTFPEHGFVWVITDVGERKLLDVGVHTIWRPEESGACGRVRREAGRLGPSTMSRVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC73</accession>
    <name>A0A132PC73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859693.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19582">
        <property type="protein sequence ID" value="KWX19582"/>
        <property type="gene ID" value="AFM11_35060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5741"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="4">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="295" mass="31640" checksum="27E37A6C399FF981" modified="2016-06-08" version="1">MAEGSLAAAVDTVVAAWAVDATMSEQTLDKFALLTRRFARFAAAHDITTLDAADIDLVTKFVAAKGRSRHGVVGPAAVATMHNRRAALRAFFRTARRMGMTLDDPTTDIAVPDREASTLRPLHDDEAALVRLFSEHATPTRHAATTALLLAGAHTSELGYIRISDIDTTVHTAWAHGSTKHRARHLPLDTWARRVIYQRIGHLTEQGANAEAIICTGSDGSEAQRQARVCVTVRDVLTRAGLTGTAGIKPSSLTAHAARRVFDDTGRIEAAAQITGSGSLDGTAALIGYRWCQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC86</accession>
    <name>A0A132PC86_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_33200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858552.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17025"/>
    <dbReference type="EnsemblBacteria" id="KWX19951">
        <property type="protein sequence ID" value="KWX19951"/>
        <property type="gene ID" value="AFM11_33200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4972"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="260"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="382" mass="40618" checksum="040F89F86B680E1C" modified="2016-06-08" version="1">MPEAYIIDAVRSPVGKKNGSLAQVHPIDLGVHVFRSIFDRNDVDPGAVDDVIVGCVDAIGGQAGNIGRNAWLAAGYPEEVPGVTVDRQCGSSQQAISFGAQAILSGTADIILAGGMQNMSWVPISSAMIVGKELGFSTPIAESENWRHRYGDQEISQFRGSELIAERWDISREEMEQFALASHQRAFAAIRAGHFDNEIVPVGDFGVDEGPRETTLEKMASLQPLVEGGRLTAALASQISDGSSAVLLASEQAVKEHNLTPRARIHHISARGADPVMMLTGPIPATQYALQKTGLTIEDIDTVEINEAFAPVVLAWMKDLKADPEKVNPSGGAIALGHPLGATGAKLFATMLNTLERTGGRYGLQTMCEGGGTANVTIIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCB0</accession>
    <name>A0A132PCB0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33250</name>
        <name evidence="2" type="ORF">AWC31_16975</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858578.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16975"/>
    <dbReference type="EnsemblBacteria" id="KWX19958">
        <property type="protein sequence ID" value="KWX19958"/>
        <property type="gene ID" value="AFM11_33250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18086">
        <property type="protein sequence ID" value="ORX18086"/>
        <property type="gene ID" value="AWC31_16975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4982"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="262" mass="27742" checksum="83328CA4EE8E4F28" modified="2016-06-08" version="1">MNLSEVPKEIDGHGLLTGKVVLVTAAAGTGIGSTTARRALLEGADVVVSDYHERRLGETRDELAGLGLGRVESVVCDVTSTEAVDALISETVAKAGRLDVLVNNAGLGGQTPVIDMTDDEWDRVLNVTLTSVMRATRAALRYFRDVDHGGVIVNNASVLGWRAQHSQSHYAAAKAGVMALTRCSAIEAVDYGVRINAVSPSIARHKFLEKTSSAELLDQLASDEAFGRAAEPWEVAATIAFLASDYSSYLTGEVISVSSQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCB3</accession>
    <name>A0A132PCB3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34765</name>
        <name evidence="4" type="ORF">AWC31_10910</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859463.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10910"/>
    <dbReference type="EnsemblBacteria" id="KWX19622">
        <property type="protein sequence ID" value="KWX19622"/>
        <property type="gene ID" value="AFM11_34765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08988">
        <property type="protein sequence ID" value="ORX08988"/>
        <property type="gene ID" value="AWC31_10910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5302"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453192" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX08988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="72" mass="7228" checksum="04BD0603126C8CBB" modified="2016-06-08" version="1">MFVCLCTGATSHVVNEIVAAGATTSKEVAEACGAGADCGRCRRTIRAIIAAAQSQPVGGRAQFNGCPSRTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCT2</accession>
    <name>A0A132PCT2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857784.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20148">
        <property type="protein sequence ID" value="KWX20148"/>
        <property type="gene ID" value="AFM11_31900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4706"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="337" mass="37712" checksum="949BFC7ADC8D57E3" modified="2016-06-08" version="1">MLSLSFASAVNERTRPIMEGTVTAEGISLNPLVSDPAETFWRMLRFGDFDICEMSISSLLMAVERGADLVAIPAFPSRRFMHIELVCHRESGIEKPEDLAGKRLGVGEYQQTAALWTRGILDHDFGVSQYDIQWYMERTPDRSHGAATGFEPPEGISLSFVPPDKSLATMLAAHEIDAALVKRAMRKPASNVVERSAHMKVSPAEFRKVTRPVFADPLAEGQRFYRAHGFVPVNHTYVVRGDVAREHPWVPFNIYQAMLRAKDVAERDLVKAVPLSLIFPEQYLQRTEELLGPNLFPYGIEANRAALETIADYSHEQGLTKKRADVNSLFAPSTLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCW5</accession>
    <name>A0A132PCW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_32405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858073.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19530"/>
    <dbReference type="EnsemblBacteria" id="KWX20067">
        <property type="protein sequence ID" value="KWX20067"/>
        <property type="gene ID" value="AFM11_32405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4809"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="5">
        <location>
            <begin position="10"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="529" mass="57843" checksum="B94C8AA8F32408DE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD39</accession>
    <name>A0A132PD39_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">AFM11_31445</name>
        <name evidence="11" type="ORF">AWC31_25600</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857518.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25600"/>
    <dbReference type="EnsemblBacteria" id="KWX20255">
        <property type="protein sequence ID" value="KWX20255"/>
        <property type="gene ID" value="AFM11_31445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14565">
        <property type="protein sequence ID" value="ORX14565"/>
        <property type="gene ID" value="AWC31_25600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4195"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX20255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX14565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="122" mass="12850" checksum="EEE7C8EEBB170416" modified="2016-06-08" version="1">MTTALVWTGVALLGGAGAVCRFLIDRAVSTRLKRGFPFGTLVVNISGALLLGFLAGLALSPHTALLVGTGFVGSYTTFSTWMLETQRLTEERQVWPAAANIVVSVALGLTAAWLGMWLGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD69</accession>
    <name>A0A132PD69_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857631.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26295"/>
    <dbReference type="EnsemblBacteria" id="KWX20291">
        <property type="protein sequence ID" value="KWX20291"/>
        <property type="gene ID" value="AFM11_31675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4239"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="398"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="482" mass="51066" checksum="7A8D9016F9D602D1" modified="2016-06-08" version="1">MAHPLSQRIDDVLDLDPTAAAIQYDGRWCTWGQVAGLARCVGALAGSGRVGIMLRNQPAHVAALLGVLAAGATVVVINPSRGDDRTRTDIAAMALPVIVGLAEDIATLVTPSPATKTVAISDLDSPPVVSAAETPVADAGRPGVAVWMLTSGTTGPPKRVDLTYDMLARSVMGREPETSPAPTELRHGVAIVNSPLVHVGGVFRVLLCIAEARPLVLLPKFDLERWAAAVREHRPRAVSLVPAALRMVLHSDLTRDDLASIRAVTSGTAPLSADDADAFTEKFGIPVLTSYAATEFGGGVASWTLADHQKYWKAKRGSVGRANPGAQLRVVDDDGNPLGPDQQGLLEVKPAQLDPTSDWLRTTDLARIDSDGFVWILGRADQAIIRGGFKVMPDDVRTALESHPAVRGAAVIGWPDERLGETPVAMVELRTDASPGELTEYLRGRLSRYEIPARIAIVETIPRTPSGKADLGAVRDQFAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDA9</accession>
    <name>A0A132PDA9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20310">
        <property type="protein sequence ID" value="KWX20310"/>
        <property type="gene ID" value="AFM11_31585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="296" mass="31587" checksum="CAC565804F0C6E2D" modified="2016-06-08" version="1">MWDDEVDVICCGTGFGGLATAIAATDADLDVFVARPGQPALNTTPGAWLGEGIDDPETREYFDGLTEDLGPRATAAPDADVTIRVMDDLKPAELSVPVAPFYGARLRDWASRCLLSPYGVLYTRILDRGTTPMRTPTGAEIDVKVIGAIEPDRGISASSAVNEWLLDQTRKRGIQTSDGTSLQRIVFEEGEIVGAVLTTADGPLALRAHHGLAIAMPSRLIAGRAHKLAEHGHSLHIALVGDSASRFGRVELLATDAAKPQRSGYCRVTRLHDGLHDAGRSHTRGGREVHGYPPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDD1</accession>
    <name>A0A132PDD1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamyl-tRNA amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857155.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26560"/>
    <dbReference type="EnsemblBacteria" id="KWX20351">
        <property type="protein sequence ID" value="KWX20351"/>
        <property type="gene ID" value="AFM11_30840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4070"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="122" mass="12864" checksum="D6D6A214EF9403AB" modified="2016-06-08" version="1">MTPAQQWRDTLRQSLLSARKARDTARVAAIRSALSAIDNAETPDAVTLDANMDGPVAGALSGLGAGEVARRELTDGEIRDLIQAEIDERLTAADQYTAGGHHTQAADLRSQAEVLAEALGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDV1</accession>
    <name>A0A132PDV1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856952.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20500">
        <property type="protein sequence ID" value="KWX20500"/>
        <property type="gene ID" value="AFM11_30500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4000"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="145" mass="15579" checksum="D552815786BC0EF7" modified="2016-06-08" version="1">MSNDPDRSTAWQTALTVIQTATPPPLPEGAEVMTVVIEYPPGDPGAPPHRHPGGPAFGYVLEGEILFELEGEPPRVLKAGEAFWEPGGDVIHYQDANNRSDIPLRFLVTMLCAPGQPMLVLVDEDELVARQGRRVAAGATTPTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDX8</accession>
    <name>A0A132PDX8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PhoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_30560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857047.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00565"/>
    <dbReference type="EnsemblBacteria" id="KWX20533">
        <property type="protein sequence ID" value="KWX20533"/>
        <property type="gene ID" value="AFM11_30560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4012"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="148"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="249" mass="26964" checksum="73CC61C15A0DAFE5" modified="2016-06-08" version="1">MNTMNAVSRPPVEAPVFRALVVDDEIGLAEVVASYLVREQFATHVAHTGPDALALARTVDPDVVVLDLGLPGIDGLEVYRQLRTFSDAYVVILTARDTEMDTILGLTVGADDYVTKPFSPRELVARIRAMLRRPRTPGSPAPNSSPAPAPVEIGPLRIVVAAREVTLHGQPIRLTRMEFDLLAALAARPGVVMSRRQLLEVVRGGPWVGNDHLVDVHIGHVRRKLGDDPAAPDYVVTVRGVGYRIGNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE55</accession>
    <name>A0A132PE55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_30545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856981.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00550"/>
    <dbReference type="EnsemblBacteria" id="KWX20507">
        <property type="protein sequence ID" value="KWX20507"/>
        <property type="gene ID" value="AFM11_30545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4009"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452990" evidence="3">
        <location>
            <begin position="31"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="327"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="459" mass="48238" checksum="6FAB8EFFCEEE21A5" modified="2016-06-08" version="1">MRPVCRLAGCLTAAAIAVTGVTVTSPTAQASHNGQQHSDTSQVAALVAELAEANQQLADVGALIQAQQEGVNKALLEVAQARDTAAAARRDAELSQQHLAEAAAAIDAAQRRFDQFAAASYINGPPKALIVAPSPDDIIAAASADQTLSIGHRNALTELHRARTEKTNQDSLARAAQQRADQALADAQRRQDAAVAALTEAQRQFGTQQAEVDRLVAARGSAQARLDAARPAATVNTSWDRLPAGPPAGPRSEASQWDTTLPMVPSANVAGDPIAIINTVLQISATSAQLTADMGRKFLAGLGILPQAAAPVDPGFTNGRIPRVYGRQASEYVIRRAMSQLGVPYSWGGGNANGPSRGIDQGANTVGFDCSGLILYAFAGVGIKLDHYSGSQYNAGRKIPSSQMRRGDLIFYGPNASQHEAMYLGNGQMIEAPFTGSQVRIAPVRTSGMMPYVTRLIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE68</accession>
    <name>A0A132PE68_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_31505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857539.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26085"/>
    <dbReference type="EnsemblBacteria" id="KWX20262">
        <property type="protein sequence ID" value="KWX20262"/>
        <property type="gene ID" value="AFM11_31505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4206"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="22116" checksum="62D4E041C73A7CF2" modified="2016-06-08" version="1">MSETRRSGRWRTGQQSRQRVIDAAREHFMRDGYEKATVRGIAAAAGVDVAMVYYFFGNKEGLFTASVLDTPEHPLHQLAHLLDDGPDDIGARLVRDFIQRWDEGASFDPLLTVWRSAAIQPLARKLLHDSLAGPVAERVSAQFGVTDAELRVELVTTHLVGLAFARYQLKIEPLASASADELVEWVGPTMQRYLTEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEE3</accession>
    <name>A0A132PEE3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040139.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20695">
        <property type="protein sequence ID" value="KWX20695"/>
        <property type="gene ID" value="AFM11_29180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3720"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="70" mass="8230" checksum="A1B19C50EE2257EE" modified="2016-06-08" version="1">MTTQQRNTDIDDERPTRLNAEAADKFIEHLSMHDREVQRHRLISTGAWAMPAATHWHLRFMAWTTKESPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEH8</accession>
    <name>A0A132PEH8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040138.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20694">
        <property type="protein sequence ID" value="KWX20694"/>
        <property type="gene ID" value="AFM11_29175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3719"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023921">
        <property type="entry name" value="ADH_Zn_actinomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03989">
        <property type="entry name" value="Rxyl_3153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="10"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="373" mass="38864" checksum="B2634454C66D1310" modified="2016-06-08" version="1">MKTRAAVLHGQNEQFKVQEVDLDPPGPHEVRVRLAATGLCHSDYHLVTGDLPMPYPVIGGHEGAGVIEEVGAEVTAVEPGDHVVLSFIPACGHCRSCAVGHSNLCDLGANILAGPQLDGTYRFHVGAQGAGQMCLLGTFAEHTVVPDVSVVKIDRSVPLRTAALIGCGVPTGYGAAVNKAKVRPGESVVVWGAGGIGMNAIQGAATSGARVVVAVEPDEAKRKLAYEVFGATHVVDPTAVDPVDAVLEATWNRGADVSIATPGVLTQAILAQALQALGKGGRAVLVAVPPAGADHLPIAPFDVVMFERQILGTVYGSSNPFSDIPQLIDLYQSGKLKLDELVTNTYSLDQINEGYEAMLAGRNIRGLVILSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEJ2</accession>
    <name>A0A132PEJ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040167.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20743">
        <property type="protein sequence ID" value="KWX20743"/>
        <property type="gene ID" value="AFM11_29095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3701"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="29689" checksum="65F2B44492B5B2A8" modified="2016-06-08" version="1">MTPEEKASLAASRAAVDDLATAIVQGADPEEAASALAAARQANTQLDREALLNKIHMPDDAGEYEDALRRIMMRIPDGWGRWISCPRGWYPIVIDFDRSLAEIDPDYELHQVKEKYAGLRYYFGTSESIAEADRQRMDELVDEAEEKCERTCELCGEPRVRHTTPHGWYRTLCEACASAEQKGYEPVGELVNDLTAGMDGVWRVGCYGDAPESIWDLGRGEVTVDGERYSDYEVLAMPGVLRTWRLRPADGTVVESGVVAAIERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEK4</accession>
    <name>A0A132PEK4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856099.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20769">
        <property type="protein sequence ID" value="KWX20769"/>
        <property type="gene ID" value="AFM11_28395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3556"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="161"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="277" mass="29987" checksum="CF55EA4E1E0EF988" modified="2016-06-08" version="1">MEFRRRSDHAVKRDVGAQLEVEIVAPTTLEFQIAVAPHPNTQVFESLSFTLDGKAVHPLEISGVHGNRIHKFDVSEGILSVDYAATIIGRTDPAPVTEYDLSMYLRPSRYAEADKFYGFAATEFGNYVDSTTLLEKVTSWVGNRLSYVPGSSDPIDGAVDTMLAGAGVCRDFAHLVVALLRAVNVPARVVSVYAPGLSPMDFHAVAEAFVEGQWRVVDGTLLAPRQSLVRIATGRDAADTAFLDNHKGSITLKTMVVTAVVDGELPRDSIDQLVSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PER4</accession>
    <name>A0A132PER4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_28790</name>
        <name evidence="6" type="ORF">AWC31_33020</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856275.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33020"/>
    <dbReference type="EnsemblBacteria" id="KWX20825">
        <property type="protein sequence ID" value="KWX20825"/>
        <property type="gene ID" value="AFM11_28790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11519">
        <property type="protein sequence ID" value="ORX11519"/>
        <property type="gene ID" value="AWC31_33020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3636"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="199" mass="21146" checksum="D813F5461944C3C1" modified="2016-06-08" version="1">MSTPTRWAGVPLTDRRAERRALLVDAAFRLFGEGGEAAVSVRSICRECGLNTRYFYESFADTDDLLGAVYDEVSALLAADVEAAMADAGDSLRARTRAGIAAVLGFSSADPRRGRVLFTDARANPVLAARRAATQDLLREAVLSEGGRLYPGSDPVAAQIGAAMYTGAMAELAQQWLSGNLGDDLDVVVDHALKLVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF20</accession>
    <name>A0A132PF20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855751.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10410"/>
    <dbReference type="EnsemblBacteria" id="KWX20913">
        <property type="protein sequence ID" value="KWX20913"/>
        <property type="gene ID" value="AFM11_27890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3452"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="124" mass="13440" checksum="5FFC21CF8A4A71D6" modified="2016-06-08" version="1">MRWIVDGMNVIGSRPDGWWKDRRGAMARLVDRLERWATTEGRSVQVVFESPVSPPIESAVIDIANAPEAAANSADDEIVRLVTSDSRPADITVVTSDSTLAERVRAAGASVHAAAGFRRLIDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF72</accession>
    <name>A0A132PF72_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminopyrimidine aminohydrolase</fullName>
            <ecNumber evidence="1">3.5.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:31799"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:63416"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17509"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TenA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.2" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856004.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10475"/>
    <dbReference type="EnsemblBacteria" id="KWX20988">
        <property type="protein sequence ID" value="KWX20988"/>
        <property type="gene ID" value="AFM11_27955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3465"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="2">
        <location>
            <begin position="15"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="227" mass="24996" checksum="016E2483D1092AA0" modified="2016-06-08" version="1">MHPDANQQSWSARLWQETEATYAAIVAHPFLTGLTDGTLDEKVFAHYVAQDAHYLRDYARALAIVAAKAPTLADTAMFARHAAEVFDVELGLHNELLPELGLDPAELDSTPVAPTTRAYTSYLLATAYGGSFADGLAAVLPCYWIYARVGAELLGRGSTDRRYQRWIDSYGGEEFAATVAEVLALTDRVGPTLSPSEEAGARAHFAVTARYEWMFFDAAYRLEEWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFH9</accession>
    <name>A0A132PFH9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division protein FtsI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_27460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855480.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07395"/>
    <dbReference type="EnsemblBacteria" id="KWX21109">
        <property type="protein sequence ID" value="KWX21109"/>
        <property type="gene ID" value="AFM11_27460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3366"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="90"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="298"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="638" mass="68654" checksum="AE99F806A55E4381" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFJ7</accession>
    <name>A0A132PFJ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855398.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07235"/>
    <dbReference type="EnsemblBacteria" id="KWX21083">
        <property type="protein sequence ID" value="KWX21083"/>
        <property type="gene ID" value="AFM11_27300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3335"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024381">
        <property type="entry name" value="DUF2561"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10812">
        <property type="entry name" value="DUF2561"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="177" mass="18478" checksum="D31B50F76B6062E2" modified="2016-06-08" version="1">MTGPNTELNNTDRVLLGACAVAWLAALGAAVAAVVALVDLGRGHPQGEEFADTPWLLYTVIGISVVVIVAAVPLLLRARAQADNRQPVRAPVRRPHPPSRYGFDRAAAAVEQVWLRFALSAACAIGVATAAVGLATYLMATDNDVAAWCLYGLAGLITVGMVALPILAVRQLDQLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFS7</accession>
    <name>A0A132PFS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854879.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23230"/>
    <dbReference type="EnsemblBacteria" id="KWX21181">
        <property type="protein sequence ID" value="KWX21181"/>
        <property type="gene ID" value="AFM11_26360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3139"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="189" mass="20478" checksum="1837DFFCC8AEEBAB" modified="2016-06-08" version="1">MSDPALESTRRRLSARQADTVERLGRAAVELISREGFPGLTVRRVAAEAGVGSATAYTYFSSKEHLVAEVFWRRLSASPPAVHESPDPATRVVEVLQHIASLVADEPEFAGAVTNALLGKDPDVDVLRQRIGADIRLRLVAALGPDVDGDVIEALELLYTGTLVWAGMGYESYPDIARRLEKSARLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGH6</accession>
    <name>A0A132PGH6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="2" type="ORF">AFM11_24745</name>
        <name evidence="3" type="ORF">AWC31_27000</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853980.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27000"/>
    <dbReference type="EnsemblBacteria" id="KWX21430">
        <property type="protein sequence ID" value="KWX21430"/>
        <property type="gene ID" value="AFM11_24745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14808">
        <property type="protein sequence ID" value="ORX14808"/>
        <property type="gene ID" value="AWC31_27000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2310"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX14808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="99" mass="10534" checksum="968074BA1F1E0BBB" modified="2016-06-08" version="1">MSQISRDEVAHLARLARLALTDDELDSFAGQLDAILGHVSQIQSVDVTGVEPTDNPLKDVNVSRPDTVEPCLSQDEALAAAPNAVDGRFAVPRILGEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGL7</accession>
    <name>A0A132PGL7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stearoyl-CoA 9-desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854581.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35975"/>
    <dbReference type="EnsemblBacteria" id="KWX21357">
        <property type="protein sequence ID" value="KWX21357"/>
        <property type="gene ID" value="AFM11_25920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3048"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FA_desaturase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="415" mass="47439" checksum="A83189D5D8BED907" modified="2016-06-08" version="1">MAVTDVPAFAHLTDADIENLGIELDAIRQDIEDSRGERDARYIRRTIAAQRGLELAGRLMLAASSRRSAWWAGTATLGVAKIIENMEIGHNVMHGQWDWMNDPEIHSSTWEWDMSGASKHWRFTHNFMHHKYTNILGMDDDVGYGLIRVTRDQRWKPMNLLNLFYNTMLCTLFEWGVGLQHLELGKIFKGRDDRKATLIRVREFGVKAGAQVFKDYVAWPAVTSLSPGATYKSTLKANAMANIIRNVWANAVIFCGHFPDGAEKFTKTDMVGETKGQWYLRQMLGSANFDNGPVLRFMSGNLCHQIEHHLYPDLPSNRLYEISIRVRALCEKYDLPYTTGSFLVQYGKSWRTIAKLSLPDRFLRDTADNAPETRSERMFTELEGFGVTDPQTGRRRGLKTAIETVRGWRRTKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGQ4</accession>
    <name>A0A132PGQ4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854207.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27525"/>
    <dbReference type="EnsemblBacteria" id="KWX21510">
        <property type="protein sequence ID" value="KWX21510"/>
        <property type="gene ID" value="AFM11_25205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2402"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="139" mass="15927" checksum="803DD16DF3A26A29" modified="2016-06-08" version="1">MLSLAEISDRLEIQQLLVAYSTAIDRRQFDDLDSVFTPDAYIDYRAMGGIDGHYPEVKAWLAEVLPNFPAYAHMLGNFDVRIDGDTASSRTICFNPMVLGGDDQQVLFCGLWYEDEFVRTADGWRMSRRVETKCFDRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH11</accession>
    <name>A0A132PH11_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853688.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21648">
        <property type="protein sequence ID" value="KWX21648"/>
        <property type="gene ID" value="AFM11_24315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2222"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041669">
        <property type="entry name" value="TetR_C_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17918">
        <property type="entry name" value="TetR_C_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="205" mass="22771" checksum="9A06642930418BAB" modified="2016-06-08" version="1">MVTRSPLRRRQPVQERSKRRVERIRAAAMELLEADGADAVTTRAIAERADVPVATVYQFFPNRDAILQEIVLDHLDRRDADGAAVLAALNPRSLGEVVHGIFEFHYEHLRAHPHLVTLHYTSLARGLLADPRLRRAEFADALHGALLQWGLLRPGTDPLVTTVAVEMGDRVLELAYRAGPAGDRAVLAEGERALTQYLQTYAATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH13</accession>
    <name>A0A132PH13_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25135</name>
        <name evidence="2" type="ORF">AWC31_27455</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854169.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27455"/>
    <dbReference type="EnsemblBacteria" id="KWX21497">
        <property type="protein sequence ID" value="KWX21497"/>
        <property type="gene ID" value="AFM11_25135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14886">
        <property type="protein sequence ID" value="ORX14886"/>
        <property type="gene ID" value="AWC31_27455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2388"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX14886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="135" mass="14811" checksum="94C7A7B52E26BBA6" modified="2016-06-08" version="1">MTELWVERTGVRRYTGHSSRGAEVLVGSEDVDGVFTPGELMKIALAACSGMSSDQPLRRRLGDDYPATIRVSGPADREQERYPLLEEKLEIDLSGLSEADVARLLTVVERAIDQVCTVGRTLKSGTEVKFEVTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH14</accession>
    <name>A0A132PH14_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853565.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24100"/>
    <dbReference type="EnsemblBacteria" id="KWX21611">
        <property type="protein sequence ID" value="KWX21611"/>
        <property type="gene ID" value="AFM11_24055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2170"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="236"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="696" mass="73474" checksum="27C8FCEC0AB14400" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH16</accession>
    <name>A0A132PH16_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853661.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23865"/>
    <dbReference type="EnsemblBacteria" id="KWX21639">
        <property type="protein sequence ID" value="KWX21639"/>
        <property type="gene ID" value="AFM11_24250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2209"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="295" mass="32080" checksum="15A8316749DB892C" modified="2016-06-08" version="1">MSKILLQTTIAETPNDWDVSRFSLLAEELTAAGHQVIARNRVDNTDDPVLSRVDELGFDQLWLMCVDVGDGLTATEAAAILRFRENGGGVLTARDHQDLGCCLNCLGSLGVVNEFHDKNIDPATMCDDPDNPDISWPNYHSGANGDYQPVLTDGPVHELLRTDKTASGRIEWFPAHPHEGLVSPTGSFTSVLAQGRSKATGRRFNLAVLLDGEVTAAGRPMGRALAESTFHHFADYNWDTDLGAPSFVTELPGSQIKEDPYPLAVFKDYVRNVATWLQPGAPHIPVMSSEALSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH26</accession>
    <name>A0A132PH26_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24325</name>
        <name evidence="3" type="ORF">AWC31_23790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23790"/>
    <dbReference type="EnsemblBacteria" id="KWX21649">
        <property type="protein sequence ID" value="KWX21649"/>
        <property type="gene ID" value="AFM11_24325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15585">
        <property type="protein sequence ID" value="ORX15585"/>
        <property type="gene ID" value="AWC31_23790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2224"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="68"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="304" mass="32866" checksum="BB28E1BB909BB682" modified="2016-06-08" version="1">MSILSKPVIADAWARLFSATVNPAPKPGVRFPEIPGRTTSAVIATRHGDVTATIYHPDPGETKPGVYVNVHGGGFVVGHPEQDDPWCRYLAAHANVVVVNPDYVLAPRRRFPAPVEQIYDVVCWAAAPERDWDGSRLCVGGQSAGGSLSAAASRLAMENGGPAISLQVLHYPPLDLVTATKDKHSALGAKAVLKPWMGEVFDTAYIPDPAQRRDRLASPAWGTNADDIEGIAPALIVTAEYDRLRDEARRYAEKLEAAGALAEYHEVRGVDHGYNIMSDNADVTRRMYDLMAGHVRRAVGSVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHQ0</accession>
    <name>A0A132PHQ0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_23645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853298.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21841">
        <property type="protein sequence ID" value="KWX21841"/>
        <property type="gene ID" value="AFM11_23645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2085"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="469" mass="49915" checksum="0F2DF09218F9F095" modified="2016-06-08" version="1">MSQNSRVDFDQSEMTHRQRRIALTAVGGYFVDGYDLLVLSGALLAIIPELDLSPGQVGALTASAFLGMALGSAVAGPLTDRFGRRLVFMMSMVLFVVASLLFLGTQEVWQLIALRLFIGIAIGADMPAAGALITEFVPAHRRGRYTSLAGVAWMLGSLAAIGATLGVYAVAGVDAWRWVMATGCLAALVLIVLRHKTPESPAWLRSRGRTAEADAAWRYATGRDDTFVVDAATAAHRYVSSRLLFKRPLVVLLVGITILWFFNNLYGSAILLYQPVLIQSIVTPEQFTTLIFTAATTALAVLIGAIVCFFVIERLGRRFIALGAITIVVASSIIIWAAAGTPLVVLLAFGAAIGFINGGSSLAFYAWAPELFPTLLRGRAIGLVNMVGKLGSVIGTFALPFAFAQFGTGAFLLIAGLALVNLVCVYFLTMETKGKSLDDVQRAAAARFGGEPVLDHPSLPVSSMPTATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHR2</accession>
    <name>A0A132PHR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_22245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852661.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08965"/>
    <dbReference type="EnsemblBacteria" id="KWX21898">
        <property type="protein sequence ID" value="KWX21898"/>
        <property type="gene ID" value="AFM11_22245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1799"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="219" mass="22628" checksum="C5A0E1D28837E7C9" modified="2016-06-08" version="1">MTSGAIVVSGLTKRFGNDTGLGPVHLTVPAGTLTVITGGPDAGKSTLVRCLTGVYRPDAGSVTFRLGGTDEIELIGADPRTVAWLRGRHIASFNGPLAAAPRLPAADAVARAARCDHTSALGALTRLRAQRLAPTPVGRLRPAERHTVALAAALIAARPFVLLDEPEAAADPASVAVWVQRAIEGGAAVLATATPDSTLASLATATGELRRGRIEWRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI52</accession>
    <name>A0A132PI52_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23785</name>
        <name evidence="4" type="ORF">AWC31_29860</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000018">
        <property type="protein sequence ID" value="ORX13649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853373.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29860"/>
    <dbReference type="EnsemblBacteria" id="KWX21867">
        <property type="protein sequence ID" value="KWX21867"/>
        <property type="gene ID" value="AFM11_23785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13649">
        <property type="protein sequence ID" value="ORX13649"/>
        <property type="gene ID" value="AWC31_29860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2115"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044240">
        <property type="entry name" value="STR4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47377">
        <property type="entry name" value="PTHR47377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX13649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="137" mass="14880" checksum="D9E5C0D2BD5C7E41" modified="2016-06-08" version="1">MSYAGDITPEEAWKLLSENPEAVLVDCRTDAEWRFVGVPDLTSLQRDVVYIEWNRTDGSHNDAFVDDLQASGVTPGDRPVVFLCRSGNRSIGAAEAATAAGIGPSYNVLDGFEGNLDENRHRGGTGWKAVGLPWKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI61</accession>
    <name>A0A132PI61_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_22820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852852.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08380"/>
    <dbReference type="EnsemblBacteria" id="KWX21993">
        <property type="protein sequence ID" value="KWX21993"/>
        <property type="gene ID" value="AFM11_22820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1917"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="249"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="498" mass="53619" checksum="44A779C5EA9A6943" modified="2016-06-08" version="1">MTSRGVLYGVGLGPGDPELVTVKAARLIGEADVVAYHSARHGHSIARSIAERYLRPGQLEEHLVYPVTTETTDHPGGYAGAMEDFYTEAAERIAEHLEAGRDVALLAEGDPLFYSSYMHMHTRLTQRFDAVIVPGVTSVSAASAATGTPLVQGDDVLTILPGTLPEDELKRRLADTDAAVVLKLGRSYTKVREALSTTGRLDEAYYVERASTPRERVAPAGEVDAAKVPYFSLAMIPGGERRPASEGSVVVVGLGPGDYDWMTPQSRRELAAATDLIGYGPYLDRVGIRPGQRHHPSDNTDEPERARLACTLAQQGRAVAVVSSGDPGVFAMATAVLEEAKQWPGVEVRVIPAMTAAQAVASRAGAPLGHDYAVISLSDRLKPWDVIVERLTAAAKADLVLAIYNPASKTRTWQVGAMRDLLLTYRDPSTPVIIGRSVSGARPGPGESVRVVRLAELDPAEVDMRCLLIIGSSQTQWYSDTADGKTEERVFTPRNYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI63</accession>
    <name>A0A132PI63_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA ATPase forming ring-shaped complexes</fullName>
            <shortName evidence="2">ARC</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arc</name>
        <name evidence="6" type="ORF">AFM11_23010</name>
        <name evidence="7" type="ORF">AWC31_08200</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer. Assembles into a hexameric ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852917.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08200"/>
    <dbReference type="EnsemblBacteria" id="KWX22025">
        <property type="protein sequence ID" value="KWX22025"/>
        <property type="gene ID" value="AFM11_23010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10145">
        <property type="protein sequence ID" value="ORX10145"/>
        <property type="gene ID" value="AWC31_08200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1953"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02112">
        <property type="entry name" value="ARC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041626">
        <property type="entry name" value="Prot_ATP_ID_OB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022482">
        <property type="entry name" value="Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17758">
        <property type="entry name" value="Prot_ATP_OB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03689">
        <property type="entry name" value="pup_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="285"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="296"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX10145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="609" mass="67495" checksum="7293EF5E8F483BCF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIB6</accession>
    <name>A0A132PIB6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetic acid degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21645</name>
        <name evidence="3" type="ORF">AWC31_04450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852391.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04450"/>
    <dbReference type="EnsemblBacteria" id="KWX22108">
        <property type="protein sequence ID" value="KWX22108"/>
        <property type="gene ID" value="AFM11_21645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10550">
        <property type="protein sequence ID" value="ORX10550"/>
        <property type="gene ID" value="AWC31_04450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1677"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="43"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="130" mass="13840" checksum="7A63D85575941E7C" modified="2016-06-08" version="1">MLTEPAPAHLLNQLGFRDVEENDERLVIEMDNRPDLANIRGALQGGLVATLIDCAAGRLAGRHVGPGQDVTTADLNVHYLAPIITGPARAVATIVRAGRRLIVTSVDVTDAGRDRLAARATLSFAVLDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIX5</accession>
    <name>A0A132PIX5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_20660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852034.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06075"/>
    <dbReference type="EnsemblBacteria" id="KWX22253">
        <property type="protein sequence ID" value="KWX22253"/>
        <property type="gene ID" value="AFM11_20660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1469"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX22253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="447" mass="48326" checksum="8526DE43EA1701C2" modified="2016-06-08" version="1">MSATTGTLAVIGAGPKAIAVAAKAAELRAMGVPAPDVVVVERAGVAANWQAVGGWTDGQHRLGTSPEKDVGFPYRSSLVQRRNAELDERMMRHSWQSYLIDIGQFAEWIDRGRPAPTHRRWSQYLKWVADNIGMNVVSGEVTEIGVDEDQKSWVLRTHESTVTAGAVMVTGPGQAEKAILPGNPRVLSIAQFWHRAAAQELISAERVAVIGGGETAATMLNELFRHRVSTITVISPQVTLFTRGEGFFENALYSDPTHWAGLTLAERRDAMNRTDRGVFSARVQEALLADDRIRHLRGRVAHAVARDERIRLTLQTDRPAGAGVRSSSERLETVHGFDLVIDGSGADALWFVPLLAQDALDMLELGLGSQLTGDSLQESIGYDLAVTGVTPKLFLPGLAGLNQGPGFPNLSCLGLLSDRVLGADLGIDTAMAADRTIRSTDEQQSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJV4</accession>
    <name>A0A132PJV4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_19135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the phytochrome family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851626.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15205"/>
    <dbReference type="EnsemblBacteria" id="KWX22615">
        <property type="protein sequence ID" value="KWX22615"/>
        <property type="gene ID" value="AFM11_19135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1161"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PHYTOCHROME_2" evidence="6">
        <location>
            <begin position="156"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="755" mass="82186" checksum="63BE314629E455BA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJX1</accession>
    <name>A0A132PJX1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851692.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15410"/>
    <dbReference type="EnsemblBacteria" id="KWX22649">
        <property type="protein sequence ID" value="KWX22649"/>
        <property type="gene ID" value="AFM11_19325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1198"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="237" mass="24744" checksum="6DA5AAFD1B479D7B" modified="2016-06-08" version="1">MADLLQLTPSLYRLRIPGGQAHLLNSYLWLEPDGVTLIDTGWPGSAGLIAEALAALGMRRLHVKRIVLTHFHEDHCGSAAEIADWADIEVVAGAGDASYVRGDEPGPLPVLTDREREIRPDLDASPHGPACRVDRAVRDGDVLDFAGGTRVIGVPGHTPGSIALYLPAADAVLTGDTVAEFHGQVILGVFNTDRQAAVESLARIAATGAQIAGFGHGEAVLTDAAARIAAATDPFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJY0</accession>
    <name>A0A132PJY0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851622.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15190"/>
    <dbReference type="EnsemblBacteria" id="KWX22613">
        <property type="protein sequence ID" value="KWX22613"/>
        <property type="gene ID" value="AFM11_19120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1158"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="350" mass="39314" checksum="56331C0203AAF24D" modified="2016-06-08" version="1">MPTPATELDVDGVKVRLTSPDKVYFPKLGKAGTKGKLVEYYLSVASGPMLALLKDRPTHLQRFPDGIEGEEIYQKRVPQKHPDYLETCVVTFPSGRTADALKVTHPASIIWAAQMGTVTLHPWQVRCPDTEHPDELRIDLDPQPGTGFKEARTIACDVLKPLLDELGLIGYPKTSGGRGVHVFLRIKPDWDFIEVRRAGIALAREVERRAPDAVTTSWWKEERGERLFIDYNQNARDRTFASAYSARKTPIATVSTPLSWDELRDADPDDYTIATVPDFLAGREDPWADIDSKKQSLKPLLDMVAADEEHGLGDLPYPPSYPKMPGEPPRVQPSKKVAEHWDEQGNRRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKG4</accession>
    <name>A0A132PKG4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">23S rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_18070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851252.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12140"/>
    <dbReference type="EnsemblBacteria" id="KWX22840">
        <property type="protein sequence ID" value="KWX22840"/>
        <property type="gene ID" value="AFM11_18070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.970"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="397" mass="42444" checksum="C0D3A51AD629898B" modified="2016-06-08" version="1">MNELTLTTGPAANGGSCVARHEGRVVFVRYALPGETVRVRVVDERGSYWRAEVVEVIEPSPDRVDSLCPIAGVDGAGCCDLAFADPAATRRLKGAVVANQLERLGGYHWRDEDAAAAESVGASGATGWRTRVRLDTTADGHAGFHRYHSAELVTDLGCAQLPDGLMTGLADTRWAGGAQLHIALDSDGVRHVVQSGPKNGRKSPTRVVEGDYEAVQRIRQRVWRVPVTAFWQAHRDAAALYSELVAGWAQLQPGMTAWDLYGGAGVFAAALAESVGESGRVVTVDTSRGASRSARTALADLPWVSVVTDSVRRALAGQDRPADVAVLDPPRTGAGREVIDQLAGAEVPRIIHIGCEAASFARDVGLYLSHGYAVEEIRVFDSFPLTHHVECIVVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKM8</accession>
    <name>A0A132PKM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_18580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851384.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12605"/>
    <dbReference type="EnsemblBacteria" id="KWX22896">
        <property type="protein sequence ID" value="KWX22896"/>
        <property type="gene ID" value="AFM11_18580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1053"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="280"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="312"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="533" mass="57715" checksum="0009206D6C816FED" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKT3</accession>
    <name>A0A132PKT3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851638.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15240"/>
    <dbReference type="EnsemblBacteria" id="KWX22622">
        <property type="protein sequence ID" value="KWX22622"/>
        <property type="gene ID" value="AFM11_19170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1168"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="214" mass="23096" checksum="0128866EDF3AFFE2" modified="2016-06-08" version="1">MPTQPLIVGNPVFVVVDMQESGDMPVEAVGIPHMPGYSERIDRTGQLLTAARGAGIPIVFFQEVHRPSGIDFGRELDGTEGVHCVEGRPGTALHPALLPEPGEFHIVKRRYSGFIGTDFEIVLSGLRASTLILVGGLTDVCVHYTFADAHQRDYYVRVVSDCVGGSSQYRHDAALDAMEYLQTGAVRTSDEILAAFRALADTTTTDPVLEGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKW4</accession>
    <name>A0A132PKW4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850667.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22986">
        <property type="protein sequence ID" value="KWX22986"/>
        <property type="gene ID" value="AFM11_16560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.661"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="17296" checksum="C43C3F2BD4C2BFBE" modified="2016-06-08" version="1">MTDLTVNLKINGEHREIRTRGRTSLADLLRDQLDLTGTHLGCEQGVCGACTVLVDGLPVRSCLTLAGSCEGAEVITIEGLDDADAQRLRTEFSRQGGLQCGFCTSGMVITGWELIRRREDDLSREAVCEAMSGNICRCTGYNGIVRAVLNANESGIASESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL11</accession>
    <name>A0A132PL11_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate--cysteine ligase EgtA</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthase</fullName>
            <shortName evidence="2">GCS</shortName>
            <shortName evidence="2">Gamma-ECS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">egtA</name>
        <name evidence="4" type="ORF">AFM11_19580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2 3">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851774.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15650"/>
    <dbReference type="EnsemblBacteria" id="KWX22692">
        <property type="protein sequence ID" value="KWX22692"/>
        <property type="gene ID" value="AFM11_19580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1249"/>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02034">
        <property type="entry name" value="EgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017809">
        <property type="entry name" value="EgtA_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035434">
        <property type="entry name" value="GCL_bact_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011556">
        <property type="entry name" value="Glut_cys_lig_pln_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378">
        <property type="entry name" value="PTHR34378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378:SF1">
        <property type="entry name" value="PTHR34378:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017901">
        <property type="entry name" value="GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03444">
        <property type="entry name" value="EgtA_Cys_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR017901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="423" mass="44843" checksum="021DC8CCC5EB5026" modified="2016-06-08" version="1">MAVPIRVDPGRLPPKEFTSAEQAAAHVGAGCLQDGPIGRVGLEIEAHCYDLADPMRRPGWDELSAAIATVPPLPGGSRITVEPGGAVELSGPPFDGPMAAIGALLADRAVLRAAFAREGLGLVLLGTDPLRPTQRVNPGQRYQAMEQFFTASGSSEPGAAMMTSTASVQVNLDAGPRDGWADRVRLAHALGPMMIAITANSPVLGGQFTGWSSTRQRVWGQLDSARCGPILGVDGDDPASDWARYAMRAPVMLVNSPDAVPVTNWVPFADWADGRAVLGGRRPTEADLDYHLTTLFPPVRPRRWLEIRYLDSVSDALWPAAVFTLTTLLDDPDAAEIAAQATESVATAWDRAAQAGLADRHLHAAALTCVQAAAERAPAELEESMRHLVRSVEQGRCPADDFADRAVQHGIAAAVSQLAKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLE9</accession>
    <name>A0A132PLE9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850145.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15825"/>
    <dbReference type="EnsemblBacteria" id="KWX23175">
        <property type="protein sequence ID" value="KWX23175"/>
        <property type="gene ID" value="AFM11_15205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7153"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="243"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="323" mass="34674" checksum="7C255DE2F9057B89" modified="2016-06-08" version="1">MTQPASTIDPDTARNALLALRNEIAKAVVGQDAVVSGLVIALLCRGHVLLEGVPGVAKTLLVRTLSAALQLEFKRVQFTPDLMPGDVTGSLVYDARTAEFEFRAGPVFTNLLLADEINRTPPKTQAALLEAMEERQVSVDGEPRPLPDPFIVAATQNPIEYEGTYQLPEAQLDRFLLKLNVPLPPRDQEIAILGRHAHGFDPRDLSAVQPVAGAAELAAGREAVRQVLVADEVLGYIVDIVGATRYSPSLQLGVSPRGATALLATARSWAWLSGRNYVTPDDVKAMARSTLRHRVALRPEAELEGATPDGVLDGILAAVPVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLG6</accession>
    <name>A0A132PLG6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850177.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15910"/>
    <dbReference type="EnsemblBacteria" id="KWX23191">
        <property type="protein sequence ID" value="KWX23191"/>
        <property type="gene ID" value="AFM11_15290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7172"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="267" mass="29464" checksum="239389498026D6E1" modified="2016-06-08" version="1">MTASTTSWISKLLRFDRVDADGDVFRIREPRRGAVERLFGGLIAAQSLAAAGATVDAGKLPQSLHAYFVRGGRYDADVEFRVERTRDGRAFATRRVTAVQDGAVILEMIASFHQPEPGVDWQPGRTPALNFDAAVTKTNVLDFGDLFELRTRPDDHSEFAVPPFWIRTREPVEDDPLVCACTLTYMSDLGPVPAALPPNVPLSADLGFAASLDHSIWFHRAFRPDAWHRYEVRSVNHNDSRGLAVGSLYDGAGSLVASVSQEALWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLY3</accession>
    <name>A0A132PLY3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850190.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23197">
        <property type="protein sequence ID" value="KWX23197"/>
        <property type="gene ID" value="AFM11_15320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7178"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="380" mass="42014" checksum="84C6F4320523ABCC" modified="2016-06-08" version="1">MTTVPVTAEDVFQVRKKQELANLRSLQATLATEVAAETATRSIRDRIELQLAARVEQITSQARDCATLRDIVDNAVRPIAGEVQTYLQGVLYRRAGLDNGTGAVAQWMLNDIADRAGVGPQVLVAFDDAEHIVHTFGMIRMRQQDTTVWRLPILVHELGHHVAHHLRNPEFGAFDKFPIMRYLENAANNDRDLRHLHELFADIFATYVLGAAYPTCVLIQQARGDQDFDDHDDTHPSWPARVHAMIAALRAMASIDPKDPTCHAFANLADREVEPLWSALNDGGTPASTGDLARLQQVAADVVGLLGKHCPSRLRCDFGPQHQLYKTLTATPAVTAPDGTTIAHVLDAAWRWRANNIACDEHLLTVVSNNALRWCAAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMA6</accession>
    <name>A0A132PMA6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849816.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18405"/>
    <dbReference type="EnsemblBacteria" id="KWX23471">
        <property type="protein sequence ID" value="KWX23471"/>
        <property type="gene ID" value="AFM11_14415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6991"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="401" mass="39838" checksum="65488B9DFAFAC99D" modified="2016-06-08" version="1">MRAYLDLVRVPGVVNVTASQLFARLPLGMLSLAILLHVQGLSGSYAQAGAVVAAVSVGQAVAMPVTARLAGRLGVVPTLSVAALVSGASMLALAFAGSSPVLLMTLGVLIGASVPPLMPVVRALYPKMVAGEGVRALFALDTTAQELIWVVGPVGATFLASAVSTAAPLVLSAAVTVLGTAWFLLSARRLHPGVAAGRSSFGRVLANRTVILAMVTSLLLVASFMALEVGIVAELGRDGVTAGAAIAVASVGSLIGGLLLGHRRLGIAWVVAALAAVAIGTALFGVVDNLALQFVALFFSGLGFAPAMSALYLFVSREVAEHSATEAFGWLNSSALVGGAVGTACAGVATEAHGSIGAVTVAALLATLAACCPLVARAAGPIGGVTDQSPDAVSPAAPPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMD7</accession>
    <name>A0A132PMD7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_14590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849874.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23500">
        <property type="protein sequence ID" value="KWX23500"/>
        <property type="gene ID" value="AFM11_14590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7029"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="163"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="370" mass="41129" checksum="30E1CE30C39C987C" modified="2016-06-08" version="1">MRAAPVTVHGRASWTVVDSSGLPIGEIEQFLHWLRAVGRSQNTVRSYARHLSLFYRWLSARGIAWDAVVFDGLCDFVGALSVGLPPLQTWRGGRSAATVKAVSAGVREFYEFHRVEGRGPAELVLTRNPSRLPRRSHSFLAHVEQRRPSEVSRLVRRGKSAAETVQVIDFEADFARLLQAASTKRDRLLLSALYDLGLRVGQALGLRHGDLDPMRRRVQICRREDNQNGALSKQRAQFTVDAPRRFFDLYAAYLLGEIADVDSDYVFVNLFRPPVGGPLSYSNAYQLVERIGTSAGIDDLHPHMLRHTHATALARAGWTAAEIAARLGQSHASSADVYIHLAGDDLSERLRRTEHLVWRAPQNGAGDATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMJ6</accession>
    <name>A0A132PMJ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsF</name>
        <name evidence="9" type="ORF">AFM11_14980</name>
        <name evidence="10" type="ORF">AWC31_17925</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849999.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17925"/>
    <dbReference type="EnsemblBacteria" id="KWX23559">
        <property type="protein sequence ID" value="KWX23559"/>
        <property type="gene ID" value="AFM11_14980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17206">
        <property type="protein sequence ID" value="ORX17206"/>
        <property type="gene ID" value="AWC31_17925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7106"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020815">
        <property type="entry name" value="Ribosomal_S6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01048">
        <property type="entry name" value="RIBOSOMAL_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX17206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="96" mass="10947" checksum="E3BCECC521C317C1" modified="2016-06-08" version="1">MRPYEIMVILDPTLDERTVAPSLETFLNVVRKDGGTVDKVDIWGRRRLAYEIAKHAEGIYAVVDVKAEPATVSELDRQLNLNESVLRTKVLRTDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMW8</accession>
    <name>A0A132PMW8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12870</name>
        <name evidence="4" type="ORF">AWC31_03170</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849115.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03170"/>
    <dbReference type="EnsemblBacteria" id="KWX23681">
        <property type="protein sequence ID" value="KWX23681"/>
        <property type="gene ID" value="AFM11_12870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11141">
        <property type="protein sequence ID" value="ORX11141"/>
        <property type="gene ID" value="AWC31_03170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6666"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="122" mass="13448" checksum="925EA7301109693B" modified="2016-06-08" version="1">MTRSAPGNPPSPASLRHDVEPDQLRLETASDIFRMLADPTRLHVLWLLSQKEADVAALTAATGASRTSVSQHLAKLRFAGLVATRRDGRHIVYRLNDGHLSRLVREGLNHADHRVTGEPPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN12</accession>
    <name>A0A132PN12_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_14170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849736.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09230"/>
    <dbReference type="EnsemblBacteria" id="KWX23432">
        <property type="protein sequence ID" value="KWX23432"/>
        <property type="gene ID" value="AFM11_14170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6940"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="320" mass="35142" checksum="882723F354B02F29" modified="2016-06-08" version="1">MTDLSEAQSVRAAGDSWDITESVGATALGVAASRAAETAQPDPLIRDEFAFLLVSAAGPAWAQLASSDPYWIGDDEDARRIHEMARNYQAVRTHYFDDYFAEVAHAGIRQVVILAAGLDSRAYRLDWPAGTTVFEIDQPKVLQYKTATLDAHGAVARSRYVAVPVDLRDDWPAALIENGFDPLQPTAWLAEGLLPYLPADAQDRLFELVGAHSAPGSRIAVEVFNLDPERYTEERRAERRARAAHMRAQLDLDIDVDSLMYADADRADAAEWLAAHGWEVDAVASIDEMARLGRPAREADLAQLGMDSVLLRARLDGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNA4</accession>
    <name>A0A132PNA4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protease subunit, stomatin/prohibitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849481.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03955"/>
    <dbReference type="EnsemblBacteria" id="KWX23816">
        <property type="protein sequence ID" value="KWX23816"/>
        <property type="gene ID" value="AFM11_13710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6838"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="226" mass="23581" checksum="D3F578E481D6BE83" modified="2016-06-08" version="1">MFKNRITVTAGECALEYRDGTLARVLPPGRHRIARDAAVVRVEMREQVLTLAPQEVLTSDAVSLRITVALRFAVTDAATYTEAAADPMAAVYLAAQIALRDNVSGMTAEEVMQRSARVDAAAITAAAAAAGARTGVAVTEVFVKDVIVPAEMRTAAMALATAKVNGAARLEAARAETAALRALANAGKLLDAHPALAQLRLIQHVPYGSKVVLSLGAPTDVASDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNQ8</accession>
    <name>A0A132PNQ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate--ammonia ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848208.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30500"/>
    <dbReference type="EnsemblBacteria" id="KWX23970">
        <property type="protein sequence ID" value="KWX23970"/>
        <property type="gene ID" value="AFM11_11395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6356"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="120"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="439" mass="47768" checksum="9FFE3D6F6B43CCFE" modified="2016-06-08" version="1">MSTTFADSARAAVVNGLPADAHSVVPLFPDIHGNLRGKLVDPKVISSDRALTEGIPTTDLLLAVDPLDEPITTLSTMGLKGGAKDLLLRPDLTTLRPMPWFPAAYLLLGDLYETSGEPCAVSPRQVLRKALDALASHGLKLKAAFEFEFRLFREGTWEPATAGLSYSPLTLSHVTDFIGTLRRYADELRLGLSVVHSEGAPGLIEVNVDPQDGVAAADTAALLRLVAVEAARRHGLSANFMAKPIAHEEGSSAHVHFSMWDEVGDNALGAAAGNRDDEFYRRAAWGMLTHLPALSLIYNPTINSYKRLVPGYFAPVSAACGPDDRSFALRALLKSPAASRFELRRPGADCNPYLTLAAIAASVHLGLIDRTVPDRGQLDRHDGALPTSLEGAIVEFRNRDGHLDQVLGAEFCTHYLQTREWELHAWQNAVSEWERQRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNU9</accession>
    <name>A0A132PNU9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11680</name>
        <name evidence="3" type="ORF">AWC31_30345</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848367.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30345"/>
    <dbReference type="EnsemblBacteria" id="KWX24018">
        <property type="protein sequence ID" value="KWX24018"/>
        <property type="gene ID" value="AFM11_11680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12305">
        <property type="protein sequence ID" value="ORX12305"/>
        <property type="gene ID" value="AWC31_30345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6413"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX12305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="290" mass="30982" checksum="5979EF0B414E9647" modified="2016-06-08" version="1">MSEDSANAEPTVEARATAALPTLSKAERRVGRALLADYPSAGLASAARLAERAEVSPPTVLRFAQSLGYEGFADLQVALRAELSARSSGPITRLPDAPAAGSMLDRLLQQARAQNERAAETLAMLPESALEAAVALLADTGRTLYLHGGRFSQLLAVHLAAHLEQLRSGVRVLTDPTGRDLGALLELSRTDVLVLFDYHRYERSAAVLARRVHRAGATVLLITDDLACPVAPDAEVVLAASSTVGTTYQSMAAGFLLTELLIPLVMDAVGEPARTRMALWEEQRRTELLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP04</accession>
    <name>A0A132PP04_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848508.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10035"/>
    <dbReference type="EnsemblBacteria" id="KWX24066">
        <property type="protein sequence ID" value="KWX24066"/>
        <property type="gene ID" value="AFM11_11940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6468"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022468">
        <property type="entry name" value="PhnX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03351">
        <property type="entry name" value="PhnX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="226" mass="23430" checksum="2184E3C0D0A23D6E" modified="2016-06-08" version="1">MPNDDIQLAVIDMAGTTVADDGLVNSAFEAAATAAGIPAEGEERENARQYVLDTMGQSKIVVFRALLDTEELAQLANAEFERTYAELIDNGQAHAIDGAAEAITELRDAGIKVALTTGFSGPTQEKLLAALGWQDVADLVLAPGDGVRGRPYPDLILTALIRLQADGVANVAALGDTANDVESARRAGVAIAAGALTGAHVEEQLRAAGATHVVGSITDFADLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP69</accession>
    <name>A0A132PP69_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848303.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23997">
        <property type="protein sequence ID" value="KWX23997"/>
        <property type="gene ID" value="AFM11_11555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6388"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="301" mass="33138" checksum="EA50D84EB83B3E53" modified="2016-06-08" version="1">MPETLSIATKAYPHTAFLTEPGFTVRGHGIALADADPIYKAFAPMVRELRYDVSELAIATYLQAREADIPIALLPVALSGDFHHHSLTCWPGSAELNPADLKGQRVGVRAYSQTTGLWVRGILNEEYGVDSKDVTWITTEEPHVDSYVEPANVERASGKVLDLLRRGDVVAAVLGPPALDGAQGPLVPIIPNWRDAEEAWGERHRTVPINHMLTVRRDLLESDPDTVWELYQAFGTQIAARKAAEVSPGPRVRALRFGVTDELVAALQVAIDYALQQEVIRKPVSVDELLDDFTRHLGDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP78</accession>
    <name>A0A132PP78_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849533.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29745"/>
    <dbReference type="EnsemblBacteria" id="KWX23842">
        <property type="protein sequence ID" value="KWX23842"/>
        <property type="gene ID" value="AFM11_13870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6870"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="246" mass="25914" checksum="ACF9E6DED5207834" modified="2016-06-08" version="1">MAAALSAITEHVHFAQTDLVNWTLVTDSDGVLLIDAGFPGQREDVLGSVRQLGFGVDDIKAVLLTHAHIDHFGTAIWLAKTHGTPVFCHANEVGHAKREYLEQASPADVVRHIWQPRWLKWSATITAKGGMNHAGIPTTQPLSNEVAAGLPGSPVAIPTPGHTGGHCSYIVDGVLVSGDAIVTGHPLLRGIGPQLLPSVFNHDEDGCLRSLSALGMLDTDVLLPGHGSVWRGSIADAAEQAIARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPE1</accession>
    <name>A0A132PPE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847094.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24209">
        <property type="protein sequence ID" value="KWX24209"/>
        <property type="gene ID" value="AFM11_09420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5921"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453522" evidence="2">
        <location>
            <begin position="31"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="383" mass="39145" checksum="EAEE745F487549E9" modified="2016-06-08" version="1">MYARIQSTVLTTVAAAGAAALVAAPVTAPAQLHAPRVVNAQIQLTASPPLGAIPLAFLRNQVLYCSVICPFVVQGAITVPLAAVQTPVTFLDALAATGSLPRAVGMAAASVTGAANDAAEGIILNDVNRVVPKAFNTLEIAVVQLMRVGSAVLTPAELPDAVNTARETVLAALNQPLPGPGVPVPTETGAETLPEVVAVEAIKVTAAVAFQAGELLLLGVVQTVDAGAQELARSGDPLAAVSAAAAQATEVVDVASDIVSDSVDTAVTNIRGALDNPFRTARPTTETPRAEVQSASASSADAPPPARRVHREAGRAATQASATAEPSKTADRPVRKLVRDVSRTVRSVTGSLADAPRKTLQHNKSEDSKENRATHDRSDKRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPI8</accession>
    <name>A0A132PPI8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoacid:ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09655</name>
        <name evidence="3" type="ORF">AWC31_05570</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847224.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05570"/>
    <dbReference type="EnsemblBacteria" id="KWX24250">
        <property type="protein sequence ID" value="KWX24250"/>
        <property type="gene ID" value="AFM11_09655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09697">
        <property type="protein sequence ID" value="ORX09697"/>
        <property type="gene ID" value="AWC31_05570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5969"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="75"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="360" mass="39074" checksum="CAB423141DFC4807" modified="2016-06-08" version="1">MTDLIGADLGLTESGLNKTSLVPKTDQPQKGKDFTSDQEVRWCPGCGDYVILNTIRNFLPELGLRRENIAFISGIGCSSRFPYYLETYGFHSIHGRAPTIATGLALARPDLSVWVVTGDGDALSIGGNHLIHALRRNINITILLFNNRIYGLTKGQYSPTSEVGKITKSTPMGSLDYPFNPVSLALGAEATFVGRALDSDRKGLSEVLRGAAAHRGAALVEIMQDCPIFNDGSFDALRKEGAEERLINVTHGEPITFGADGEYCVVKSGYGLEVAKTADVAASEIVVHNAEVDDPAYAFALSRLSEQNLDHMVMGIFRQVNRPTYDDAAREQVNTAIESKPHDTAALQSLLRGKDTWTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPR4</accession>
    <name>A0A132PPR4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ORF">AFM11_09350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847052.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05875"/>
    <dbReference type="EnsemblBacteria" id="KWX24197">
        <property type="protein sequence ID" value="KWX24197"/>
        <property type="gene ID" value="AFM11_09350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5907"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="152"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="624" mass="68762" checksum="08D404E8E1DAC1EE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPU0</accession>
    <name>A0A132PPU0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_10240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13502"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847532.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18685"/>
    <dbReference type="EnsemblBacteria" id="KWX24350">
        <property type="protein sequence ID" value="KWX24350"/>
        <property type="gene ID" value="AFM11_10240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6086"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="5"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="124"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="581"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX24350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="665" mass="69673" checksum="4A3DC9BCC69EB612" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ58</accession>
    <name>A0A132PQ58_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847851.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19410"/>
    <dbReference type="EnsemblBacteria" id="KWX24453">
        <property type="protein sequence ID" value="KWX24453"/>
        <property type="gene ID" value="AFM11_10895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6218"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="29916" checksum="E2F89603A079A821" modified="2016-06-08" version="1">MTYRRHIVDIDGLATSYLEAGAGDTVILLHGGEFGVNAELGWERTIDALAEDYRVLAPDMLGFGGSAKVVDFNDGRGMRIRHIARFCAELGVEAAHFVGNSMGAINLLVDATSDAPRLPVRSLVAICGGGEIQRNEHMAALYDYDATFEGMRRIVAALFADPAYPADDAYVRRRYESSIAPGAWEALAAARFRRPGLDPPPAPSSARAYERIDVPTLIVEGASDKLLPAGWAAEIAAQITGARSAVIQNAGHCPQIEQPDAVNGLLSEFLAGQRARIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ83</accession>
    <name>A0A132PQ83_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847798.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19300"/>
    <dbReference type="EnsemblBacteria" id="KWX24434">
        <property type="protein sequence ID" value="KWX24434"/>
        <property type="gene ID" value="AFM11_10785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6196"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="109" mass="12598" checksum="48BC908F6C025D6F" modified="2016-06-08" version="1">MSKLPEEFADLERFSDWCLPTEEERYQKRLNSTMEEMQDLYDAGMARLEDIMVYVDARFPLKGMPEDAKALVHLGQSIVMVSFPVEVWKQPRVLDSGAAYIQLVKEPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQD1</accession>
    <name>A0A132PQD1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847978.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19250"/>
    <dbReference type="EnsemblBacteria" id="KWX24505">
        <property type="protein sequence ID" value="KWX24505"/>
        <property type="gene ID" value="AFM11_10735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6186"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="167" mass="18066" checksum="CDAFD4A8DEBCD631" modified="2016-06-08" version="1">MRYRLDVVAPCVVDAVRFAGGWLVDRVMAGWDVTVLIGADEDVRPLEILGVDTMDLESVLVSWQDRPHPQTVAVAADLFNSDERVRRGVLGALEQGRTEVTLWGEQCPADLSVDPVRHELSAAARAFKAQALAAVQHPEAAAVGYTEAFRCGTMISRSVPADLIPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQJ5</accession>
    <name>A0A132PQJ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847216.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05585"/>
    <dbReference type="EnsemblBacteria" id="KWX24477">
        <property type="protein sequence ID" value="KWX24477"/>
        <property type="gene ID" value="AFM11_09640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5966"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453207" evidence="2">
        <location>
            <begin position="38"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylas" evidence="3">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="149" mass="15001" checksum="3546B6AEEAA50544" modified="2016-06-08" version="1">MTRSVWITALSGALAMGPMALSTATAGADSVNWDAIAACESGGNWSTNTGNGHYGGLQFKQSTWAAHGGIGSPSTAPREEQIRVAENVLRTQGLGAWPRCGAAGGAPAVWGAPAAGSGCQAVRPGAVLGIIDLRRLCATLLNPLGAFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQK5</accession>
    <name>A0A132PQK5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24487">
        <property type="protein sequence ID" value="KWX24487"/>
        <property type="gene ID" value="AFM11_10125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6061"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="148" mass="15891" checksum="6291A7512E82346D" modified="2016-06-08" version="1">MPVAGLVRVLARFWIPLVLVAVLAISGLAMNRMHGIFGTHIKSGAAPAAGDDIVEFNPKRVVYEIEGLSGTSGHVSYLDADAQPHTESFSSLPWRHEVVTTLPTVFANLVAQGDSDVITCRIVVNGEVRDTQTVNQHNAQAFCLEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQK8</accession>
    <name>A0A132PQK8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08040</name>
        <name evidence="2" type="ORF">AWC31_24640</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000014">
        <property type="protein sequence ID" value="ORX15215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846250.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24640"/>
    <dbReference type="EnsemblBacteria" id="KWX24621">
        <property type="protein sequence ID" value="KWX24621"/>
        <property type="gene ID" value="AFM11_08040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15215">
        <property type="protein sequence ID" value="ORX15215"/>
        <property type="gene ID" value="AWC31_24640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5458"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024495">
        <property type="entry name" value="DUF2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10969">
        <property type="entry name" value="DUF2771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX15215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="162" mass="17817" checksum="63C11C91F6609D04" modified="2016-06-08" version="1">MKRTIAILAVVVVLAIAGTTVGVWRLSSSHGEQLPQISAYSDGHLVRVGPFRYCPVLDLNNCQDPRDAGELRVNEDNPVQLSVPSAIARAPWRLLRVYENPIDTTVSVYRPETTLAVTIPTVDPQRGRLTGLAVQLLTLVQDEAGEEFPLPHAEWSISTVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR88</accession>
    <name>A0A132PR88_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purS</name>
        <name evidence="6" type="ORF">AFM11_08685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846976.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13685"/>
    <dbReference type="EnsemblBacteria" id="KWX24851">
        <property type="protein sequence ID" value="KWX24851"/>
        <property type="gene ID" value="AFM11_08685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5587"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="79" mass="8490" checksum="DC21F4FD3ECCC5A2" modified="2016-06-08" version="1">MAKVVVHVMPKAEILDPQGQAIVGALGRLGHDGISDVRQGKRFELEVDDSVADETLAEIAESLLANTVIEDFSVSREDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR92</accession>
    <name>A0A132PR92_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13170"/>
    <dbReference type="EnsemblBacteria" id="KWX24815">
        <property type="protein sequence ID" value="KWX24815"/>
        <property type="gene ID" value="AFM11_09200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025975">
        <property type="entry name" value="Polysacc_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14099">
        <property type="entry name" value="Polysacc_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453520" evidence="1">
        <location>
            <begin position="30"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="285" mass="30660" checksum="CD15D9AD9A128E6C" modified="2016-06-08" version="1">MMRLPTAIAATVAVVSISASTACGGNSSATPVATSCPLSVTTAAGTCPVSLDSEVVFTGDYDTGDLTQWATLQTRGWNNFPGKYCGYNACVRDGGSGHATAARFEIRDGDVPPFGGGIRSEVRTAGDPAGGASVREGDERWYELSVKFDADFRNPRTGAHDWFVIMQWLPADDSIPALTLQVSLDGELELGGDARSVQFRRPIGDIARGMWVDYVLHVKFSADPHVGFVEVWRDGRLSVPMHHRPTLGMAEYSYLKQGAYRSPDSVGTQVLWHDGLRVVAPGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRE1</accession>
    <name>A0A132PRE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclophilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12840"/>
    <dbReference type="EnsemblBacteria" id="KWX24893">
        <property type="protein sequence ID" value="KWX24893"/>
        <property type="gene ID" value="AFM11_05465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4282"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="165"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="322" mass="33105" checksum="F4548297DF893C84" modified="2016-06-08" version="1">MSAPPPYGGYPPGHPGYPVGYPPPRTNSMAIASLACAFLFAPLGIVFGHISLSQIKRNGEQGRGMAIAGLVIGYALTALSILLVVLMVIFAVALVQTADNLPREGTRSASPGNALPAFDPPPNLGANCQYPATTEPAVKPATPPRTGTVPTEPAIVTASITTDRGNIGIDLANGQAPCTVNNFASLAQQGFFDDTPCHRLTTGELSVLQCGDPSGTGMGGPGYQFPNEYPTNQYRLSDPALRTPVVYPRGTVASANAGTGTNGSQFFVVYEDSLLPPTYTVFGTVDETGLATVDRIAAGGIEGGGDDGKPATPVTITSALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS88</accession>
    <name>A0A132PS88_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ectoine/hydroxyectoine ABC transporter ATP-binding protein EhuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_07035</name>
        <name evidence="6" type="ORF">AWC31_17680</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845551.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17680"/>
    <dbReference type="EnsemblBacteria" id="KWX25165">
        <property type="protein sequence ID" value="KWX25165"/>
        <property type="gene ID" value="AFM11_07035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17522">
        <property type="protein sequence ID" value="ORX17522"/>
        <property type="gene ID" value="AWC31_17680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4606"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX17522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="253" mass="27541" checksum="8FC5791E221DFE69" modified="2016-06-08" version="1">MTAMVRAENVCKNFGALQVLKGVTLEVGKGEVLCLVGPSGSGKSTFLRCINHLEQVNAGRLYVDGELVGYRERGGKLHEMRPKDAAKQRRDVGMVFQHFNLFPHRTALENIIEAPIQVKKVKKAAAVARAKDLLDQVGLSAKADAYPAQLSGGQQQRVAIARALAMSPKLMLFDEPTSALDPELVGEVLGVMKKLASEGMTMVVVTHEMGFAREVADKLVFMDGGVIVESGEPREVMSNPKHERTKAFLSKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS94</accession>
    <name>A0A132PS94_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_07295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845712.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17420"/>
    <dbReference type="EnsemblBacteria" id="KWX25209">
        <property type="protein sequence ID" value="KWX25209"/>
        <property type="gene ID" value="AFM11_07295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4659"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="488" mass="50023" checksum="CE66EDF068EF4403" modified="2016-06-08" version="1">MTGTEASPSTPATDAPHPRPALLVAGLSLVVLTVAVLQTAVVPVLGVIAAQLHSSSVAVSWAVTANLLAAAAATPLIGRLADLYSKKRVLLAVLIVVLAGSVLAAATASVPMLILGRVLQGASYALYPISIAILREELAEDRLVSAMSVLSGTLGFGGGMGLVVTGLLMAGDAGYHRVFWLTTGFTAVVIVVTVLAVPAHKPTARGTIDWLGALGLACGLSAVLLAVTQGNSWGWAAPMTVAFLAGGVVVLVAWWFWERRAAHPLVSTGMMAKRAILLTNLATVFVGMGLYFAFLGLTQFVQISREAAGYGFGANVLQASVYFLLPGALAGFLVALISGRFIDRFGARRVLVVAALAGIAGFAMLAVAHDRAWQVIVAGVLANAYISLGYGALPALVVSEVDAGQTGVATSMNAIARTIGSSSAAAVVAVLLGHSAIPTEASFVTIFLAGAVTAGLAMALIAVSRAPDRHRDSMQNLSESRAMNHEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSI2</accession>
    <name>A0A132PSI2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845917.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17480"/>
    <dbReference type="EnsemblBacteria" id="KWX25270">
        <property type="protein sequence ID" value="KWX25270"/>
        <property type="gene ID" value="AFM11_07235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4647"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="30"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="273" mass="28388" checksum="4974EF720A0067DC" modified="2016-06-08" version="1">MSSQRHPLAIGVIGGPTAVIDYGGLRFVTEPTFDPPGEYGAYRKEIGPALSPAELGAVDAVLLSHDLHPDNFDHAGRTFAQTVPVILTGPQAAGRLGGNAHGLAAFTSTEVRGADSGPGVTVYAVPAQHGPSDGDRDEYGNINTEVTGFVLQYDGLPTVYVSGDNASIAPVREIADRFPAVDVAILHTGAARVPTKNSGRALTLTADRAAAVAELIGASIVVPVHCEGWSLYSETPEDIRRSFDDAGIGARLRDARPGFWAVHGTDSAGSLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSJ0</accession>
    <name>A0A132PSJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03200</name>
        <name evidence="3" type="ORF">AWC31_21895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843885.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21895"/>
    <dbReference type="EnsemblBacteria" id="KWX25309">
        <property type="protein sequence ID" value="KWX25309"/>
        <property type="gene ID" value="AFM11_03200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16671">
        <property type="protein sequence ID" value="ORX16671"/>
        <property type="gene ID" value="AWC31_21895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2515"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453552" evidence="1">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="88" mass="8972" checksum="E33F478BEAB81578" modified="2016-06-08" version="1">MKSRLTTLAGCLLVGGASAAIGLAPLAAAEPSAPKEPHLLPQCQVTGGSSVEGGQTTECASEGNVQIDATPPQPGYGMFPWDDEFFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSK3</accession>
    <name>A0A132PSK3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843834.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25290">
        <property type="protein sequence ID" value="KWX25290"/>
        <property type="gene ID" value="AFM11_03075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2484"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="64" mass="6945" checksum="55F3D66E0CA3F273" modified="2016-06-08" version="1">MGRPVRPDEVAAAIAFLASSSASYITGAQLTVDGGYTAPRQGQRRHEPARTAPRCVHRRLHNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSL7</accession>
    <name>A0A132PSL7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_03460</name>
        <name evidence="8" type="ORF">AWC31_21690</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844030.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21690"/>
    <dbReference type="EnsemblBacteria" id="KWX25348">
        <property type="protein sequence ID" value="KWX25348"/>
        <property type="gene ID" value="AFM11_03460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16632">
        <property type="protein sequence ID" value="ORX16632"/>
        <property type="gene ID" value="AWC31_21690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2566"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX16632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="406" mass="41211" checksum="1E57A08373424232" modified="2016-06-08" version="1">MTTSLERPTGPSSVVAPDPTVRWLAVFALALGGFGIGTTEFVAMGLLPDIASGFGITEPTAGHVISAYALGVVIGAPVIAALTARLPRKALLLGLMAVFTLGNLASMVAPSYPTLVVARFVAGLPHGAFFGIAALAAAHLMGPQNRAKAVAHVLSGLTIATVLGVPIASWLGQALGWRSAFGLVVVIGVLTLTALWFWLPDQLRAMHVSSALTELGALRRPQVWLAVLVGMIGFGGMFAVYTYISTTMTDVAGLSRSLVPVALMVFGLGMVVGNLVGGRLADVSVIRALYLSMGTLGVLLAVFVLASHNPWTALLVLFGIGAAGSAVGPALQTRLMDVAHDAQTLAAALNHSALNIGNATGAWVGGLVIAAGFGYTAPAAAGAMLAVGGLLVLTVSVALQRRGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSP4</accession>
    <name>A0A132PSP4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4Fe-4S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_03565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844083.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21590"/>
    <dbReference type="EnsemblBacteria" id="KWX25366">
        <property type="protein sequence ID" value="KWX25366"/>
        <property type="gene ID" value="AFM11_03565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2588"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="135" mass="14440" checksum="471621054976C73A" modified="2016-06-08" version="1">MIEIVSSTACIACDICVKVCPTDVFDRGADGIPVIARQSDCQTCFMCEAYCPTDALYVSPVSVPVEPGSPHASEDAVSRAGLFGDYRELVGWGRGRTPGSRRDQNPVLTSVPPLPEARLPVPAAVVNSPWNHPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSR6</accession>
    <name>A0A132PSR6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845334.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29155"/>
    <dbReference type="EnsemblBacteria" id="KWX25072">
        <property type="protein sequence ID" value="KWX25072"/>
        <property type="gene ID" value="AFM11_06520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4498"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453255" evidence="2">
        <location>
            <begin position="29"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="98"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="230" mass="23353" checksum="84B1E886F62EFAFD" modified="2016-06-08" version="1">MRSFVLRCLTVIAALAVAGIGLVTPAGAAPDDGQWDPTLPKLISAGAPGDPLAIANASLQATAQATEVTMGLGRKFLASLGLVNDAPTSVAAGSVRGPQAIEYVIRRGGTQMGVPYSWGGGKPSGPSRGIDSGANTVGFDCSGFTQFSYAGVGVLIPKYSGDQYNTGRKVPVAQAKRGDLLFWGPGGSQHVAMYLGGGRMIEASGSAGKVTVSPVRTSGLQPYAARIIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSR7</accession>
    <name>A0A132PSR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25389">
        <property type="protein sequence ID" value="KWX25389"/>
        <property type="gene ID" value="AFM11_03720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2620"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="109" mass="12265" checksum="16F9D1E500EB19F3" modified="2016-06-08" version="1">MQIRASLNSWTGISDDAGMAGGRTVGEKFNRGGWIAVDGLTNSRDCVRVRRTRAKSGASVVGDDGVRRARMTDGSAWQTRRFLMRCQIGDRERSQHEINLTDNRRWLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSS0</accession>
    <name>A0A132PSS0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844198.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21380"/>
    <dbReference type="EnsemblBacteria" id="KWX25398">
        <property type="protein sequence ID" value="KWX25398"/>
        <property type="gene ID" value="AFM11_03785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2633"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="256" mass="26304" checksum="6BC12DD0634CDA68" modified="2016-06-08" version="1">MSKLVQYTVDGAVARLTLDSPHNRNALSTALVEQLHEGFAGAAAEPGVRVVVLGHTGGTFCAGADLSEAAGRDPGDVAVDRAREMTKLLRTILELPLPVIGAIDGHVRAGGLGLVGACDLVVAGSNSTFALTEARIGVAPSIISLTLLPKMTARSAGRYFVTGEKFGAAEAAAIGLITVAADDVSAAVAALTGEIAKGSPQGLATSKALTTASILRSFDEHAEDLTQQSARLFVSDEAREGMMAFLQKRPPGWTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSV6</accession>
    <name>A0A132PSV6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_06740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845436.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28910"/>
    <dbReference type="EnsemblBacteria" id="KWX25112">
        <property type="protein sequence ID" value="KWX25112"/>
        <property type="gene ID" value="AFM11_06740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4547"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="145" mass="16234" checksum="50BFA0021E06DB47" modified="2016-06-08" version="1">MPLTGEYEPSTSDWARENAETYMASRGTQGTELQGRPLILLTTVGAKTGKIRKTPLMRVEHDGQYSIVASLGGAPKNPVWYYNVKKNPHVELQDGAAVGDYEAREVFGDEKAVWWERAVAAFPDYADYQTKTERQIPVFVLTPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT26</accession>
    <name>A0A132PT26_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_03950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844283.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21215"/>
    <dbReference type="EnsemblBacteria" id="KWX25424">
        <property type="protein sequence ID" value="KWX25424"/>
        <property type="gene ID" value="AFM11_03950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2668"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453316" evidence="4">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="25563" checksum="99E29C471A5807E5" modified="2016-06-08" version="1">MTRARAGAAMLAAITLVSACSSEPSTPAGDSIVVFAAASLKPAFTQIGEQFKADNPDVKVEFSFAGSSDLVTQLTQGADADVFASADTRNMDKAAQAGLVDGAPVDFATNTLTIAVAPGNPKGIKGFQDLAKPGVAVVVCAPPVPCGGATEKVEKATAVTLSPVSEETSVTDVLNKVTTGQADAGIVYVTDAADAGDKVTSVPFPEAAQAVNTYPIAVLKDSQNSELANRFVDLVTGEAGQKVLAEEGFTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTH9</accession>
    <name>A0A132PTH9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2'-5' RNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844747.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20115"/>
    <dbReference type="EnsemblBacteria" id="KWX25615">
        <property type="protein sequence ID" value="KWX25615"/>
        <property type="gene ID" value="AFM11_05125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2906"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="174" mass="18873" checksum="EDE991377CB3B7EB" modified="2016-06-08" version="1">MALAVCLLFDRRSERAIRALWDRVEQQGVASLCSHTHGRHVPHVSYAVLRRWDLAAVSDALAGIRAGAPVQLSFDGVGLFRRGRVWLVAGVSADFVARQERVVDAVTATGAELHKHYRPGVWLPHCSLAPRATLAQVPQVVATVLDVLPLRVTLDHAALINSATGELNALQTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUC2</accession>
    <name>A0A132PUC2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842579.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34120"/>
    <dbReference type="EnsemblBacteria" id="KWX25913">
        <property type="protein sequence ID" value="KWX25913"/>
        <property type="gene ID" value="AFM11_01085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.223"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="101" mass="10323" checksum="665D0E6C0DF602A2" modified="2016-06-08" version="1">MGVVDAARIDVEALMDAARQYEAAADIVDATVRTRLSRAAFDGSAAGQAHVAQGDAVRAALDDLAEPLGEWARAAGEIGAVLRASADRYVAADGRAASRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUL9</accession>
    <name>A0A132PUL9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choline oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_02040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843042.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34820"/>
    <dbReference type="EnsemblBacteria" id="KWX26049">
        <property type="protein sequence ID" value="KWX26049"/>
        <property type="gene ID" value="AFM11_02040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.418"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="3">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="516" mass="55365" checksum="D9BB00227F298387" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUY4</accession>
    <name>A0A132PUY4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_02240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843153.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35020"/>
    <dbReference type="EnsemblBacteria" id="KWX26084">
        <property type="protein sequence ID" value="KWX26084"/>
        <property type="gene ID" value="AFM11_02240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.458"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="7">
        <location>
            <begin position="33"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="8">
        <location>
            <begin position="409"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX26084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="581" mass="62881" checksum="7A375D01AD3837F5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV95</accession>
    <name>A0A132PV95_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01235</name>
        <name evidence="3" type="ORF">AWC31_34270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843610.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34270"/>
    <dbReference type="EnsemblBacteria" id="KWX26235">
        <property type="protein sequence ID" value="KWX26235"/>
        <property type="gene ID" value="AFM11_01235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12112">
        <property type="protein sequence ID" value="ORX12112"/>
        <property type="gene ID" value="AWC31_34270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.253"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035165">
        <property type="entry name" value="DUF5319"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17252">
        <property type="entry name" value="DUF5319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX12112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="134" mass="14835" checksum="06396296C35C2C4E" modified="2016-06-08" version="1">MRDHLPPGLPPDPFADDPCDPSAALDAIEPGQPLDPQERTAVEADLADLAVYEALLAHKGIRGLVVCCDECQQDHYHDWDMLRANLLQLLVDGTVRPHEPAYDPEPDAYVTWDYCRGYADASLNEATSDSDGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PW27</accession>
    <name>A0A132PW27_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">General stress protein CsbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_00910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842488.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26222">
        <property type="protein sequence ID" value="KWX26222"/>
        <property type="gene ID" value="AFM11_00910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.188"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="70" mass="7158" checksum="9B7C3027120FAF41" modified="2016-06-08" version="1">MGIADDMRNKADDLKGRAKEAAGAATGNEDLKTEGQADQGIAAAKQKVADAAEKVKDGVEAVKDKLTGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB59</accession>
    <name>A0A132PB59_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859633.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19563">
        <property type="protein sequence ID" value="KWX19563"/>
        <property type="gene ID" value="AFM11_35070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5742"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="182" mass="20360" checksum="FCA3A0F30FFF9EA3" modified="2016-06-08" version="1">MKAGLTVLVPPHAGTAKPTPLTTIDCPCGDAHALWTDEGRLHERAILDTGETHLQRLPVAKVYARRNRAGTYRWYIDFATTCGTVHHQRIDTTDDDAARGYNRAEHLRQHTKTEDGDSVYDRCYGWREDAESLNNTLDRTLYGGRMTAHTATRQHGVMIGFALGRNAIAAYIHQRHQQPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB64</accession>
    <name>A0A132PB64_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19581">
        <property type="protein sequence ID" value="KWX19581"/>
        <property type="gene ID" value="AFM11_35055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5740"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="102" mass="10599" checksum="2DC84A1748D886C1" modified="2016-06-08" version="1">MSRGHGDRPPVAYLADGVWPDGQLVADAPPSASAALHLARELHVAMEESRTGQRALAAATGIAHTTIGRILAGTVLCDIGTLAKLEHALGRPLWPRAGFGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBE7</accession>
    <name>A0A132PBE7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859469.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10920"/>
    <dbReference type="EnsemblBacteria" id="KWX19624">
        <property type="protein sequence ID" value="KWX19624"/>
        <property type="gene ID" value="AFM11_34775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5304"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="1">
        <location>
            <begin position="126"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="245" mass="26465" checksum="91C742F77E42F66D" modified="2016-06-08" version="1">MEKVIVTMRAAQADETWCARLLSRVRDNLLDIGPAGLTLNVRDAAVRDSLMTLTTLDPPVVAVVSMWVHQYYGAQARAAIDLLAGECDVAAAYLVTESVPLPAPVTAPGERTDGLANIALLRRPSDLDERTWLHRWHIDHTPVAIETQATFGYTQNTVVRALTPDAPVLAAIVEELFPLPAVSDLHAFFGAADDADLADRMQRMVASTDAFGASSNIDTVPTSRYVYSSPFAGRVVPLATPGRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBP1</accession>
    <name>A0A132PBP1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859174.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19714">
        <property type="protein sequence ID" value="KWX19714"/>
        <property type="gene ID" value="AFM11_34285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5199"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="114" mass="11448" checksum="D558827CB79C2547" modified="2016-06-08" version="1">MTITVDTPPTNPETAALDLIVRIAESVAGGAALRASLQDFAGALHIEGALSGLSTTDDARLAAATIAEAACTADDPVGALRIRAAAFRAGCWDCADPRGLAQALDGAATVLDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBZ5</accession>
    <name>A0A132PBZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell envelope protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858945.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08020"/>
    <dbReference type="EnsemblBacteria" id="KWX19853">
        <property type="protein sequence ID" value="KWX19853"/>
        <property type="gene ID" value="AFM11_33735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5084"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="domain" description="DUF1254" evidence="2">
        <location>
            <begin position="70"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1214" evidence="1">
        <location>
            <begin position="340"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="469" mass="51676" checksum="33C2E65C5BB7D9EB" modified="2016-06-08" version="1">MILAASLVACATEPEQPDQPPPPQQAVPLDQVRAIAKEAYIYGFPMVDTYRVQYAYFVNKDDPEYKGGWNDIHNTARVYTPEDKAIQTPNSDTPYSFVGADLRTEPLVLTVPPIEQDRYYSLQFIDGYTYNFAYVGSRTTGNGGGSYLLAGPGWQGDKPEGIKEVIRSDTDLAFVLYRTQLFGESDLDAVKKIQAGYQVAPLSVYLKQPSPPAAPPIDFTPPLTPEAQKTSPQFFEILNTALRFAPVKPEEQEMRARFATIGIGPDGDFDADKLTPETRKAIEDGMADAWAEFNMFKKDKVDTDQVGSAQFFGTAADLKGNYLYRMAGAVLGIYGNTAAEALYPGATADSKGEPLTGANRYTYRFAKDQLPPVNAFWSLTMYELPASQLVANPIDRYLINSEMLDTLVPDPDGGYTLTIQNESPGVGNPAQAANWLPAPKGPFMLVLRLYWPKPDALNGTWKAPKPERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC71</accession>
    <name>A0A132PC71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19894">
        <property type="protein sequence ID" value="KWX19894"/>
        <property type="gene ID" value="AFM11_33485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="76" mass="8505" checksum="F599F698A4D09A56" modified="2016-06-08" version="1">MDRPVQSASDVGITCEKAEFTNTSRVVRQPIVLHFTGFAEVVVALVSMSESYCDPVVFAFAILFRRFKFVSTKIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCF6</accession>
    <name>A0A132PCF6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">(4Fe-4S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_32900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858349.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32345"/>
    <dbReference type="EnsemblBacteria" id="KWX20008">
        <property type="protein sequence ID" value="KWX20008"/>
        <property type="gene ID" value="AFM11_32900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4909"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00273">
        <property type="entry name" value="TIGR00273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="LUD_dom" evidence="7">
        <location>
            <begin position="80"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="320"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3390" evidence="8">
        <location>
            <begin position="414"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX20008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="489" mass="53043" checksum="E6AD74BE3722FB1E" modified="2016-06-08" version="1">MTATFLGNPGLGNLRGDESFPSAARTALANSQLRRNIGHATHTIRAKRLRAVAECADWEELRAAGSAIKQDVMARLPELLEQLERNVTERGGVVHWARDADEANRIVTDLIRATGSVEVVKVKSMATQEIGLNEHLEAEGIAAFETDLAELIVQLGHDKPSHILVPAIHRNRAEIREIFEREMPDAGKLTDEPRVLAMAARAHLRRKFLTAKVAVSGANFGVTETGTLAVVESEGNGRMCLTLPETLITVMGIEKIVPTFSDLEVFMQLLPRSSTAERMNPYTSMWTGVHPGDGPQEFHLVLLDNGRTQVLADEVGRAALHCIRCSACLNVCPVYERTGGHAYGSVYPGPIGAILSPQLTGTTGHGDPNASLPYASSLCGACFEACPVRIDIPSILVHLRAKQVDSERGGLPGGQDLAMRAAGWAMAGAGRFSLAEKALAAGRLIAGKDHRISALPWPASKWTASRDIPEPPKETFRQWWVRTHGEDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCM7</accession>
    <name>A0A132PCM7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_32400</name>
        <name evidence="5" type="ORF">AWC31_19525</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX17025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858070.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19525"/>
    <dbReference type="EnsemblBacteria" id="KWX20066">
        <property type="protein sequence ID" value="KWX20066"/>
        <property type="gene ID" value="AFM11_32400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17025">
        <property type="protein sequence ID" value="ORX17025"/>
        <property type="gene ID" value="AWC31_19525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4808"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX17025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="131" mass="13554" checksum="69B5C666E68B8830" modified="2016-06-08" version="1">MPTRVLVAKPGLDGHDRGAKIVARTLRDAGFEVIYTGIRQRIEDIVSIALQEDVALVGLSILSGAHVALTTRTVEALRAADAGDIAVVVGGTIPQGDVQKLLDAGAAAVFPTGTGLDTLVTEVRALTEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCP7</accession>
    <name>A0A132PCP7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858321.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32215"/>
    <dbReference type="EnsemblBacteria" id="KWX19997">
        <property type="protein sequence ID" value="KWX19997"/>
        <property type="gene ID" value="AFM11_32840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4897"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="25"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="483" mass="50060" checksum="5F2B58E1394A9503" modified="2016-06-08" version="1">MNTQNAIAELDTKHGILIDGSAHGASRTFEVHDPATGLVIAEVADGTVADAESAVDAAHRAFGDWAASSPRQRSEILRRVYELMLADTDRLVALICAENGKSQADARAEVGYAAEFFRWFSEEAVRTDGVYGISPAGGTRTLVTHKPVGVAALVTPWNFPAAMATRKIAPALAAGCTVVLKPAAETPLTALAIAAILSAAGVPDGVVNVVPTTDAAAVVSAWLADDRVRKVSFTGSTGVGRVLLKQAADRIVNASMELGGNAPFVVTADADVAAAVQGAMVAKYRGGGQACTAANRFYVHAAVVDEFVARFSAEVSALRVGPAADPASQIGPLVSARAAERVAAAIESAVADGAVIAAAAETPDDGWFVAPTVLTGVAPDAAIIADEIFGPVAPVVVWETEDDLLRWVNDTEYGLAAYIYAGRLQDALRLAESFDAGMVGINRGIVSDPSAPFGGMKQSGLGREGARDGLHEFQETQYFSVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCQ7</accession>
    <name>A0A132PCQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858346.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32340"/>
    <dbReference type="EnsemblBacteria" id="KWX20007">
        <property type="protein sequence ID" value="KWX20007"/>
        <property type="gene ID" value="AFM11_32895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4908"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="42"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="202" mass="21207" checksum="30CD4A747FD756C2" modified="2016-06-08" version="1">MTDARTAVLGRIRDALAAAPPAPVVVPRDYDRAPLTGAGDIERFSETVAEYRANVYRIAADEIAATVRKLVGPDAAVVIPADLPADWVRDVRTVVDEPALSIDELDSADAVLTGCAVGIAATGTIVLDAGATQGRRAITLVPDHHICVVRADQIVDTVPQGFAALSTDRPLTFISGPSATSDIELERVEGVHGPRTLDVLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCS9</accession>
    <name>A0A132PCS9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34025</name>
        <name evidence="3" type="ORF">AWC31_02475</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859028.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19772">
        <property type="protein sequence ID" value="KWX19772"/>
        <property type="gene ID" value="AFM11_34025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11026">
        <property type="protein sequence ID" value="ORX11026"/>
        <property type="gene ID" value="AWC31_02475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5142"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452977" evidence="1">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="99" mass="10277" checksum="22A6C8B9F5285C6D" modified="2016-06-08" version="1">MRKTVIATLTAGLALTGLALAGPAAAAPTGQTSAQQTIKDLQAEGYRVIQTKVGSGSIDNCTVSAVRPGRDITELRAAPRGNTEEVVRYTTVYVDLKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCW8</accession>
    <name>A0A132PCW8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_32020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857849.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31875"/>
    <dbReference type="EnsemblBacteria" id="KWX20170">
        <property type="protein sequence ID" value="KWX20170"/>
        <property type="gene ID" value="AFM11_32020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4730"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="10"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="192"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="30655" checksum="7F155D84381168B7" modified="2016-06-08" version="1">MSTAAAEFTTVGLLGLGTMGAGIAQVFAASGRDVVVLETDQDRIAAGLAVIERFLDGGIAKGKITEADKAAVLARISATTEAADLASVDLVVESVTEDPDIKKALLGKVAEVVGDQTPICTNTSALSVTDLAAALPNPARVAGLHFFNPAPLMRTVEVVRALQTNDALIDRLVALVDTFGDKDAIVVKDRPGFLVNALLLPYLNDVITELDDGLATAEDIDTAIKLGLGYKAGPLELLDMIGLDVQLHATEAAYAATRDPRYAPPPLLRQMVAAGRLGNKTNNGFRTHDSENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD03</accession>
    <name>A0A132PD03_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_32200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857980.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20215">
        <property type="protein sequence ID" value="KWX20215"/>
        <property type="gene ID" value="AFM11_32200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4767"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="152"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="303"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="368" mass="40051" checksum="950D0BE3FB50C243" modified="2016-06-08" version="1">MEHCRLIRQEVGPYGADGLVDEDDLLTEGKAHAMFMLETLGSGSTDIAPAQQVGRKRAQQGVPLAAVMSAYRVGIRYWWEQIGRKTQELALPSESLLIAGSELWQHQAEYTEALAAAYQEVATERSIERQHARSALVAGLLEGSLPVGISTWDAARMLKLPEAGNYVVVAIGLDTIDPGIAKTEAALEAIGFPSAWRLEADAQVGLVALSAAARLTRLQEILKHNSAHRIGISPLYDGIPPTGEGLRYARIALLAATDADQIVVFDHNPYAIAAVSDPQTMARYAQTVLGALNDLSTPDKTVLLETFRQWITAGGTVAETAELLFCHPNTVRYRLRRLKELTGRDIARPSDVAELWLAVEADTRLHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD45</accession>
    <name>A0A132PD45_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857423.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20224">
        <property type="protein sequence ID" value="KWX20224"/>
        <property type="gene ID" value="AFM11_31265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4158"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="172" mass="18047" checksum="5CF70C6FC3F36EC8" modified="2016-06-08" version="1">MKFDLSAVTNGAARLWRSRLGRLRTSTLVLIVAFIALSWVQQNYAPKPASTESPATQVVPPGFVPDPDYTWVPRTNVAPPRTTTSTTTPTTTPETTTTTEETPTTTSPTETTSPTSPTSTTPSPGPQTTVVDPDGPGLLPPITLPVFPGPAPQTPAGQPQIADEPVAPAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD56</accession>
    <name>A0A132PD56_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_31420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857501.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25575"/>
    <dbReference type="EnsemblBacteria" id="KWX20250">
        <property type="protein sequence ID" value="KWX20250"/>
        <property type="gene ID" value="AFM11_31420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4190"/>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlcB" evidence="5">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="204" mass="23039" checksum="9C0AE3D474894B48" modified="2016-06-08" version="1">MTEIDEALEPVLKRELTDIADAVRVVPAPPIPVVAEPYGIRLADADADAEMVSEWMNRPHLVEAWEYDWPPERWRRYLQAQLDGEYSRPLIASFKGTPAGYIEVYRAAKDSIAPRYDADPHDIGVHAAIADLNLVNKGIAPFLLPKVVASVFELDPNCRRIMFDPDHRNTGARRVCEWAGCTFLGEHDMSNRRMALYALPRTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDA4</accession>
    <name>A0A132PDA4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20318">
        <property type="protein sequence ID" value="KWX20318"/>
        <property type="gene ID" value="AFM11_31755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4255"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="182" mass="20473" checksum="6892C9F3D679CB13" modified="2016-06-08" version="1" fragment="single">MIVVGADVHKRSHTFVAVNEVGRRLGEKTVKATTEGHQAALIWARELFGTDLIWGIEDCRNMSARLERDLLGAGQKVVRVPTKLSAQTRKSARTRGKSDPIDAEAVARAVLREPDLPVACHDETSRELKLLTDRRDILVAQRTSAINRLRWHVHELDPEQAPAARKLKLTTHQQALQDWLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDC7</accession>
    <name>A0A132PDC7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26520"/>
    <dbReference type="EnsemblBacteria" id="KWX20343">
        <property type="protein sequence ID" value="KWX20343"/>
        <property type="gene ID" value="AFM11_30800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4061"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="173" mass="18407" checksum="F8BF62DE86EF5502" modified="2016-06-08" version="1">MMTGLLIELNVNGKRYSVHADVRTTLLDLLRERLHLTGTKKGCDHGLCGACTVDVDGERVLSCLTLAASVAGSSVDTVEGLADGDELAPIQQAFVDHDAFQCGYCTSGQLSSAQAMLREHARGDLSAESFCTTDVTSPPCLTDREIRERMAGNICRCGAYANIVAAIQDVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDG6</accession>
    <name>A0A132PDG6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase IV</fullName>
            <shortName evidence="4">Pol IV</shortName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dinB</name>
        <name evidence="6" type="ORF">AFM11_30940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857203.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26660"/>
    <dbReference type="EnsemblBacteria" id="KWX20368">
        <property type="protein sequence ID" value="KWX20368"/>
        <property type="gene ID" value="AFM11_30940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4090"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="5">
        <location>
            <begin position="5"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="4">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="353" mass="38136" checksum="49C857898579A4C3" modified="2016-06-08" version="1">MTSWVLHVDLDQFLASVELRRHPELEGLPVIVGGSGDPTEPRKVVTCASYQAREFGVHAGMPLRTAARRCPDATFLPSDPAAYDEASEQVMGLLRDLGHPLEVWGWDEAYLGADVTDPVELAERIRTVIAAETGLSCSVGISDNKQRAKVATGLAKPAGVYVLTEDNWMAVMGDRPPDALWGVGPKTTKKLATMGISTVADLAATDAAVLTAAFGPSTGLWILLLAKGGGDTEVSSEPWVPRSRSHVVTFAQDLTDRSEIDAAVVELAHRTLAEVVEQHRIVTRVAVTVRTKTFYTRTKIRKLPAPTTDRGVITDTALAVLDQFELDRPIRLLGVRLELAMEQTTEPVVGDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDK0</accession>
    <name>A0A132PDK0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein NrdI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nrdI</name>
        <name evidence="5" type="ORF">AFM11_30970</name>
        <name evidence="6" type="ORF">AWC31_26690</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Probably involved in ribonucleotide reductase function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NrdI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857223.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26690"/>
    <dbReference type="EnsemblBacteria" id="KWX20374">
        <property type="protein sequence ID" value="KWX20374"/>
        <property type="gene ID" value="AFM11_30970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14753">
        <property type="protein sequence ID" value="ORX14753"/>
        <property type="gene ID" value="AWC31_26690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4096"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00128">
        <property type="entry name" value="NrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020852">
        <property type="entry name" value="RNR_Ib_NrdI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004465">
        <property type="entry name" value="RNR_NrdI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37297">
        <property type="entry name" value="PTHR37297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07972">
        <property type="entry name" value="Flavodoxin_NdrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005087">
        <property type="entry name" value="NrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00333">
        <property type="entry name" value="nrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX14753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="147" mass="16238" checksum="809AC4E247E431B2" modified="2016-06-08" version="1">MANLVYFSSVSENTHRFVEKLGLPAIRIPLHGRIEVDEPYVLILPTYGGGRATPDINDGGYVPKQVIAFLNNEHNRSLIRGVIAAGNNNFGAEFAYAGNVVSRKCGVPYLYRFELMGTPDDVAAVRAGLEDFWKDQTCHQPSQLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDM4</accession>
    <name>A0A132PDM4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_30070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856745.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20435">
        <property type="protein sequence ID" value="KWX20435"/>
        <property type="gene ID" value="AFM11_30070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3908"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="96"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="311" mass="33392" checksum="18F244B8F0E87AAB" modified="2016-06-08" version="1">MLAVLGAPPRGDGWAVEWKFDGQRATVVVEDGRAVVYSRSGADVTQAFPELQGVAAAVGHRRLILDGEIIAPDRDGLPSFARLQQRWPQNRRPTPELVRQVPVQLAAFDVLALDGHDMTTLPYTERRGALDNLAPLDSGRGVLAVPKAWTDVSPSDMLAIAASHRMEGIVVKRLDSRYRPGRSALWVKCPVRATAELVIVGYWPASGPMASTAIGALLLAGRDVAGELVVVGRVGTGFSAPTRRHLYELLHAIECGEPVDGGDGVSVGVRWVKPVYVGEVAYREYSPTGGLRHGSWKGLRPGCPSEVGMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE61</accession>
    <name>A0A132PE61_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-quinone oxidoreductase</fullName>
            <ecNumber evidence="9">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_29925</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856624.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25265"/>
    <dbReference type="EnsemblBacteria" id="KWX20615">
        <property type="protein sequence ID" value="KWX20615"/>
        <property type="gene ID" value="AFM11_29925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3877"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 8 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0874">Quinone</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="10">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="12">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="11">
        <location>
            <begin position="232"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX20615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="795" mass="83747" checksum="2BB72BE4129368C3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEH1</accession>
    <name>A0A132PEH1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048896473.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20738">
        <property type="protein sequence ID" value="KWX20738"/>
        <property type="gene ID" value="AFM11_28970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3674"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="15"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="503" mass="54486" checksum="EA26E71816ADBD8D" modified="2016-06-08" version="1">MSDMDHYRMYIAGKWVDSSETVEILSPTDGLPVATVAWGDVTDIDRAVAAAKDAHESGVWRERTPAERAEVIDAIADRLEERIETLTVLQVRENGATVRAAGAFLVGYSIAHLRYFAELARKFPFEQLGELLEVPTLATGIVRHEPVGVCGAIVPWNFPLLLAVWKLGPALAAGNTVVLKPDEQTPLTLLELARAADEVGLPAGVLNIVTGPGVTTGARLAEHPDVRKIAFTGSTEVGREVMRAAAGNIKKVTLELGGKGANIVLDDADVDLAVDGTLFGFLLLSGQICSSGTRLLVADSIYDTFMTKLVERIATVNIGDPMKTETDIGPLVSLKQKQRVEKYIAVGQEEGATVAYQGSPPTDPDLSNGHWVAPVILTDVTNDMRVAREEIFGPVLVVIRYDNDDDAVRIANDSEYGLSAGIWSTDNQRALALARRLEAGTVWVNDWHMVNCLHPFGGFKQSGIGRELGPDALREYLEQKFVHVDMTNDRSKRAFSLVVSTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEK6</accession>
    <name>A0A132PEK6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_28375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856087.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32655"/>
    <dbReference type="EnsemblBacteria" id="KWX20766">
        <property type="protein sequence ID" value="KWX20766"/>
        <property type="gene ID" value="AFM11_28375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3549"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="791" mass="84452" checksum="1D3D16222E2EEAEC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEP4</accession>
    <name>A0A132PEP4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Death-on-curing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856174.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20791">
        <property type="protein sequence ID" value="KWX20791"/>
        <property type="gene ID" value="AFM11_28580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3596"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006440">
        <property type="entry name" value="Doc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426">
        <property type="entry name" value="PTHR39426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01550">
        <property type="entry name" value="DOC_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="126" mass="13700" checksum="D36BFA78F528941D" modified="2016-06-08" version="1">MTEYLDRDDVLTAGSIAFGGELKVRDYGLLDAAVARPQTTVFGVDAYPEIWDKAAALLQSLARNHALVDGNKRTAWAAAWTFLHINGFELAADFDVDRAEDLMNEVATRDCDVSEIAASLFSFAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEP5</accession>
    <name>A0A132PEP5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_29190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040144.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20697">
        <property type="protein sequence ID" value="KWX20697"/>
        <property type="gene ID" value="AFM11_29190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3722"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="218" mass="24261" checksum="191A65659F34CB96" modified="2016-06-08" version="1">MWFHPRGRGTVSGAIVTQRTRGSERRERILAAAAELIAERGYHAVSMTDLGVAAGIVGPGIYRHFDSKAAVLASLFERVIDALLERASTIVDQARDEREALTGLVADHVSLVINDRELAIVYYRELHNLSDEQRRRLRRKQRLYLEEWVHVVAELRPELDEADVRAVVHGAIGAIQSILHYRDTGLPPERVAARLAAMGYAVLGIAASDDLPRIVNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEP6</accession>
    <name>A0A132PEP6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856824.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20462">
        <property type="protein sequence ID" value="KWX20462"/>
        <property type="gene ID" value="AFM11_30260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3949"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="149" mass="16815" checksum="E9CDE5E7DAAF22B1" modified="2016-06-08" version="1">MSSAAIHVPEALEPLLAPRPIPRTKMQIILPAVIGLAVLGMIALMMSQPALRSGPMAVFSLLFPIMMIGSMLYMFTGNRFGGVGDNQQLTPAQMEIRRREYFHDLDELRDEVHAAAEAQFNQFRWLHPEPDQLLGLVGSDRMWERSRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEW6</accession>
    <name>A0A132PEW6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27645</name>
        <name evidence="2" type="ORF">AWC31_10180</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20875">
        <property type="protein sequence ID" value="KWX20875"/>
        <property type="gene ID" value="AFM11_27645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08875">
        <property type="protein sequence ID" value="ORX08875"/>
        <property type="gene ID" value="AWC31_10180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3403"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX08875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="148" mass="14662" checksum="D1D639E7201342EF" modified="2016-06-08" version="1">MTANSGYSAQIRAEAASMSRDTFANGEFTLWVRMKERQMSVGGSLVRIAAGAAVAGAAAMGAIAAAHAAPVGAGADVNPVPLRPLSVQEDPACGWLGWRHPLCGGGAFETPADDGIPGDNAAEGGIPAPAMVPNIDGSLSPPGTPGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEW8</accession>
    <name>A0A132PEW8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856272.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33015"/>
    <dbReference type="EnsemblBacteria" id="KWX20824">
        <property type="protein sequence ID" value="KWX20824"/>
        <property type="gene ID" value="AFM11_28785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3635"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="47"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="37283" checksum="866DAF5C540ADF4D" modified="2016-06-08" version="1">MFMPHEFVGQWLNQKFDRDIRKHYFRGMDFAGPHGDPGWFGPGSAVWHVHSHLHALIFGLQCAAYMERLDPSIYWMGMHHSRLVQRDENGVASPRIDPAGAAVRLGHSIAFFIGTAYGSTDTAERLAKTVRSMHHTIKGTRPDGAVYDADDPDWLRWNYATVVWGLATAHELYHPQPLRGKRLDRYYGEFVRVGHALGGTDLPTTKAETLDCLESYLPRLALTHGAAMATGPNLGLPQSAIDWAIRDTMPKWAMQLIQHQSPNFVERAARRSMAWSIINGLELAAGPTPEFRQAKARVADGIDPALAPHTEPTYVPGSDALLRRDEIEDSFATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF61</accession>
    <name>A0A132PF61_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ANTAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_28435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20847">
        <property type="protein sequence ID" value="KWX20847"/>
        <property type="gene ID" value="AFM11_28435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3565"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="148"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="220" mass="23179" checksum="215B5B5D6556B149" modified="2016-06-08" version="1">MAAIDKAAAPMRLCDACVAALPVDRAAIAVHVDGVGLEILCASDHIAERLEWEQITLGEGPGWDAVSAGGPVVATDLAGGDGRWPVFAAEAAWGAGAMYALPLQVGAIRVGVLDLYCDAADPLSTTDFADAVAVADLVSAILLTVGRDGPIIGALDSWWDQPLSTREVHQATGMVMAQLDVDAREAYVRLQAFAYGNDRLISEVAREVVARQLRFDRDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFE4</accession>
    <name>A0A132PFE4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28000</name>
        <name evidence="3" type="ORF">AWC31_10520</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855793.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10520"/>
    <dbReference type="EnsemblBacteria" id="KWX20927">
        <property type="protein sequence ID" value="KWX20927"/>
        <property type="gene ID" value="AFM11_28000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08924">
        <property type="protein sequence ID" value="ORX08924"/>
        <property type="gene ID" value="AWC31_10520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3474"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="40"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX08924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="229" mass="24260" checksum="3F4570AE82AEE985" modified="2016-06-08" version="1">MGRLTTFIVSLGLLVGLFGQVPTQRYTTSGLDPRINRIAVIGDSYTTGTPAEGGMGPKGWTTIAWQELAQRGVQVTADVVAEGGAGYVVRGNRGSIFGDLTTRAVQPDDSLVVFFGSRNDKDADPAAITRMSHDALASAERIAPAARLLVIGPPWPTADVPPTVLHIRDILRAQARDAGATFIDPIAEGWFVGRPELIGADGIHPTDAGHAYMADKIAPLIGAELPRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFK7</accession>
    <name>A0A132PFK7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">murF</name>
        <name evidence="11" type="ORF">AFM11_27470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855486.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07405"/>
    <dbReference type="EnsemblBacteria" id="KWX21111">
        <property type="protein sequence ID" value="KWX21111"/>
        <property type="gene ID" value="AFM11_27470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3368"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="135"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="344"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX21111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="503" mass="50611" checksum="65AC9AA16B28EF96" modified="2016-06-08" version="1">MIEMTIARIAEIVGGELADITPEQAAATRVTGTVEFDSRAVGSGGLFLALPGARSDGHDFAASAVAAGAVAVLAARPVGVPAIVVRPEPGATDSGSGALEYDTDGSGAAVLAALGRLAAAVAAELVAGGLTIIGVTGSSGKTSTKDLLAAVLAPLGEVIAPPGSFNNELGHPWTVLRATTDIDFLILEMSARHRGNIAALAAIAPPSIAVVLNVGTAHLGEFGSREAIAKTKAELPQAVGPSGVVVLNADDTAVAAMAEETTARVVRVSRSPGADVWAGPVTLDALARPRFTLHTAHAQADIELAVHGDHQVSNALCAAAVALECGATLPQVASALSAAGPVSRRRMQVSTRGDGVTIINDAYNANPDSMRAGLKALAWMARESAGEGGGKRRSWAVLGEMAELGDDAISEHDAIGRFAVRLDVSRLLVVGSGRTMNAMHHGAVMEGSWGSESTMVADADAALALLQDELQPGDVVLVKASNSVGLGALAETLVAGPVGDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFP6</accession>
    <name>A0A132PFP6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26275</name>
        <name evidence="6" type="ORF">AWC31_23325</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854840.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23325"/>
    <dbReference type="EnsemblBacteria" id="KWX21168">
        <property type="protein sequence ID" value="KWX21168"/>
        <property type="gene ID" value="AFM11_26275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15508">
        <property type="protein sequence ID" value="ORX15508"/>
        <property type="gene ID" value="AWC31_23325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3122"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX15508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="276" mass="30138" checksum="57FF8286D4295D4B" modified="2016-06-08" version="1">MTEQPPAIDCRHLTHRYGEFTAVDDFTLQVQPGETLGLLGPNGAGKTTAVRVLTTLTPVQSGEVRIFGLSAGKHTMDIRHNIGYVPQQLSIESALTGRQNVELFARLYDVPRSERAERVTAALDSMQLLDVADAAAGTYSGGMVRRLELAQALVNRPLLLILDEPTVGLDPIARDSVWEQVRHMQSEFGMTVLLTTHYMGEADALCDRVALMHHGRLQAVGTPAELKAAVSSQTGSDDATLEDVFRHYAGSDLDAETQHAGIREVRATRRTARRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG13</accession>
    <name>A0A132PG13_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_26535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854975.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21214">
        <property type="protein sequence ID" value="KWX21214"/>
        <property type="gene ID" value="AFM11_26535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3177"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="254" mass="28567" checksum="7942361C85FA8A7E" modified="2016-06-08" version="1">MHANRDAKTVGAVAALTGVSVRTLHHYDHIGLVVPSVRTAAGYRGYTDTDIERLHLVLVYRSVGLALDEIRTLLDDADADVLAHLQRQHSLLCERAEQLQQTIKAVEELMSAHNNGIQLSAEEQVEIFGSAVFDEHHEEAQERWGGTEEWRQSQIRTAEMSKQDWIEFKAENDALLQALADGKRAGMRPGSPEADALAARHRANVSRFYDCTDDMHVCLAQMYLADERFTRYYDDVEPGLARFVHDIITASVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG33</accession>
    <name>A0A132PG33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26655</name>
        <name evidence="2" type="ORF">AWC31_22680</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855034.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22680"/>
    <dbReference type="EnsemblBacteria" id="KWX21234">
        <property type="protein sequence ID" value="KWX21234"/>
        <property type="gene ID" value="AFM11_26655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15398">
        <property type="protein sequence ID" value="ORX15398"/>
        <property type="gene ID" value="AWC31_22680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3202"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX15398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="116" mass="12985" checksum="2A59C8F117757238" modified="2016-06-08" version="1">MAVRMSSQRFEELVSDALDLVPPELAAAIDNVVVLVEDRNPDEPEILGLYQGVALTERDSWYAGSLPDTITIYRDALLDICDDEEQVVDEVAITVIHEIAHHFGIDDERLHELGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGH2</accession>
    <name>A0A132PGH2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="9" type="ORF">AFM11_24750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853983.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27005"/>
    <dbReference type="EnsemblBacteria" id="KWX21431">
        <property type="protein sequence ID" value="KWX21431"/>
        <property type="gene ID" value="AFM11_24750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2311"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="493" mass="51246" checksum="FE39F527C78B7737" modified="2016-06-08" version="1">MTELIRRDAATLAAQIAAKEVSSTEVTQAHLDQISATDDRFNAFLHVAADEALAEAGRIDAAVAAGEQLPSPLAGVPLALKDVFTTTDMPTTCGSKILEGWRSPYDATVTAKLRAAGIPILGKTNMDEFAMGSSTENSAYGPTRNPWNTERVPGGSGGGSAAALAAYQAPLAIGSDTGGSIRQPAALTATVGVKPTYGTVSRYGLIACASSLDQGGPCARTVLDTALLHAVIAGHDPRDSTSVDAAVPDVVAAAKAGASGDLKGVRVGVVKQLRGEGYQPGVLESFNAAVEQLTALGAEVTEVDCPHFDHAMAAYYLILPSEVSSNLARFDAMRFGLRVGDDGTHSAEEVMALTRAAGFGPEVKRRIMIGTYALSAGYYDAYYNQAQKVRTLIARDLDRAYENVDVLVSPATPTTAFGLGEKVDDPLAMYLFDLCTLPLNLAGHCGMSVPSGLSPDDGLPVGLQIMAPALADDRLYRVGAAYEAARGPLPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH73</accession>
    <name>A0A132PH73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853799.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23560"/>
    <dbReference type="EnsemblBacteria" id="KWX21685">
        <property type="protein sequence ID" value="KWX21685"/>
        <property type="gene ID" value="AFM11_24560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2273"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="189" mass="20521" checksum="73696410D2AFCC0B" modified="2016-06-08" version="1">MTTETAPRRRSEKSRVAIIEATRELLLERGFDGLSIEAVAAKAGVGKQTIYRWWPSRPALVADVLLEDADKILATMPATDDVTADLVSWAGTLTSALTTKRGYAMLRTLTAASLEHEDTAARLRAGFSRPLLDSVRNRLLAENIAAETAHAAADALLGAVVYAILSEGRNYERQRAETTARTIVASLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHH2</accession>
    <name>A0A132PHH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853716.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23740"/>
    <dbReference type="EnsemblBacteria" id="KWX21657">
        <property type="protein sequence ID" value="KWX21657"/>
        <property type="gene ID" value="AFM11_24375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2235"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="276" mass="30081" checksum="0AFB9BE8762D9602" modified="2016-06-08" version="1">MDNAPELRTLAVEGVRSPVLVGGADSPETVVFVHGNNAGARWDALLEPISELACVIAPEMPGFGAADKPAQWPYTVAAYAAHLDGLLRQLGVRRAHLVAHDFGGPWALAWAVDHLDSVASITLINAPVVIDHFAAKLWRTPVLAEMLTRIGTPAILRKVLASRDPGLPPDAVASIAEHMFAPGTPDAVLKLYRSTGPDAIAPYVDRLADFDRNVLIVWGAEDHYVPFEQTDDYRRIFRHCEIHAVPGAGHWPWLEQPDVVAGYLTNFLRRQPGGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHI4</accession>
    <name>A0A132PHI4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23220</name>
        <name evidence="3" type="ORF">AWC31_27985</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853086.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27985"/>
    <dbReference type="EnsemblBacteria" id="KWX21771">
        <property type="protein sequence ID" value="KWX21771"/>
        <property type="gene ID" value="AFM11_23220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14979">
        <property type="protein sequence ID" value="ORX14979"/>
        <property type="gene ID" value="AWC31_27985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1997"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX14979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="249" mass="27918" checksum="0987D88C0C9FD034" modified="2016-06-08" version="1">MVYTRNWYGGLVAASAEHRVLKHQVVRAQLDRMLDDMEVGDPFPAEREIAEQFDVARETVRQALRELLLDGRVERRGRTTVVAKPKVQLPLAMGSYTEAAKDKGLSAGRILVGWTDLTADETLAGQLAIEPGAPIIQLERVLTTDGVRVGLETTKLPAARYPGLRETFDYRVSLYAEIRSRGIKFERTVDTIDTALPDARESALLTVDSRTPMFLLNRVSYDQNGVPIEQRRSLYRGDRMTFTAVMHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHJ7</accession>
    <name>A0A132PHJ7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_23575</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853255.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28300"/>
    <dbReference type="EnsemblBacteria" id="KWX21828">
        <property type="protein sequence ID" value="KWX21828"/>
        <property type="gene ID" value="AFM11_23575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2071"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="143"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX21828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="388" mass="43276" checksum="9BD8313525A8A265" modified="2016-06-08" version="1">MGLDDRDALQVLRDAVDPENGSDTLIRDFYTHWFATDLSARDLFPPDMDVQRKVFASALAWLFGELIAQRAEEPVAFLAQLGRDHRKYGVLQSHYDTMQDALYTTLRTHLAAAWTDRLAEAARDAVALAIGVMRGAADAEQSPAYCDGTVVEHHRVTRDVSVIRLQLDQPLFYHPGQYVTVQVPQWPRRWRYLSPAIPADRSGAIEFHVRSVTGGMVSTAIVGETRPGDRWRISSPHGAMQVDRAGEDVLMVAGSTGLAPLRTLIMDMTLHGVNPRVHLFFGGRYPCDLYDLKTLWQIASTNPWLSVTPVSEYSSDPPWARDYPDVQPPRGLHVRQTGKLPEVVTRYGNWGDRQILICGGPDMVDATKAALIAKGAPPERIQHDPLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHN9</accession>
    <name>A0A132PHN9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854237.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27595"/>
    <dbReference type="EnsemblBacteria" id="KWX21522">
        <property type="protein sequence ID" value="KWX21522"/>
        <property type="gene ID" value="AFM11_25275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2417"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="PTHR37466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="128" mass="13778" checksum="95D68741F1763EED" modified="2016-06-08" version="1">MADRNVLGGPLEECGTDPLTGFYRDGCCSTGDADLGRHTICAVVTAEFLEHQRSIGNDLSTPAPHFRFPGLVPGDRWCVTAANWLRAHEDGHAAPVVLAATHERTLDVVPLEVLSQYAVDVPDDLADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHW0</accession>
    <name>A0A132PHW0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_22220</name>
        <name evidence="7" type="ORF">AWC31_08990</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852650.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08990"/>
    <dbReference type="EnsemblBacteria" id="KWX21893">
        <property type="protein sequence ID" value="KWX21893"/>
        <property type="gene ID" value="AFM11_22220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10278">
        <property type="protein sequence ID" value="ORX10278"/>
        <property type="gene ID" value="AWC31_08990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1794"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX10278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="212" mass="22852" checksum="0102A1147691E462" modified="2016-06-08" version="1">MTTTNSAAGQERKRPGRPPGTSDTRERILATARELFARNGIDKTSIRAIAAGAGVDPALVHHYFGTKTQLFAAAIHIPIDPMAVIGPLRETPVEQIGHTLPSILLPLWDSEMGKGFIATLRSILAGNDVSLVRSFLQEVIVAEVGSRVDNPVGSGRIRVQFVASQLVGVVMARYILELEPFKSLPVEQIAETIAPNLQRYLTGDLPGLGELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI08</accession>
    <name>A0A132PI08_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YahG/YlbE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08610"/>
    <dbReference type="EnsemblBacteria" id="KWX21951">
        <property type="protein sequence ID" value="KWX21951"/>
        <property type="gene ID" value="AFM11_22595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1869"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009499">
        <property type="entry name" value="DUF1116"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024033">
        <property type="entry name" value="Uncharacterised_dom_sf_YlbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06545">
        <property type="entry name" value="DUF1116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="422" mass="45167" checksum="89E28F554EAF4D77" modified="2016-06-08" version="1">MSTQLDTTALDVEAANAAAFAHLDEADPWVIDVAPAHEVLPGFRDNLVLTSGAPMPWSAYTGGQREALIGGALFEGLAATREEAIAGFADGRIEVGACHDFSAVGSLAGIYTASMPVFVVVNRTRGNLGFCNFYEGKEPRRLNYGCYDDGVRDRLRHVNDVLAPVVGEAIRRQGGIALKPLIARALRMGDEVHSRNAAASILFNREILPAILDMVDAKVSGVRETLLHLAENDYFFLRLSMAAAKASADAMSVPGSTLVSAMAFSCRGFAIKLAGLGDTWFEGPPPIHQGKLFTGHTEDEITWMGGESPITETVGLGGFAQACALSLQEYQGGSPEIMIERNREMYAITHGENSVYRIPLFGFRGTPTGIDARKVLETGVLPVMDVGLAGRDGGQIGAGVIRAPRECFVDAMAEHARRFGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI18</accession>
    <name>A0A132PI18_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydrodipicolinate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_23620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853285.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28365"/>
    <dbReference type="EnsemblBacteria" id="KWX21837">
        <property type="protein sequence ID" value="KWX21837"/>
        <property type="gene ID" value="AFM11_23620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2080"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="359" mass="38780" checksum="F24E6457B0CB576B" modified="2016-06-08" version="1">MTSKVRVFQVATGNVGTEMIKRIVKRPDLELIGLHCYTPEKVGRDAGEIAGIEPVGVTATGSIDDIIAARPDVLTFHGVFPDEDLYVKVLEAGINIVTTADWITGWHRDTNHPHPSGKPVSQLLAEACEKGGSTFYGTGMNPGLNQILGVVCSADVAEIENVTTIESVDVSCHHSKDTWIEVGYGLPVDDPSIPGKLEKYTRVFADSVLMMADCFGLTLDEVKFSYELGACTKDVDLGWYKLPKGSLGGNYIKYQGMIDGVPRVETHLEWQMTPHTDPSWDIKGCYITQIKGDPCVYNKHMIFPKPGVDLSDPDSFASIGMTVTGLPALNAIASVVKAPPGLLTSADVPLRGFAGRFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI96</accession>
    <name>A0A132PI96_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_21490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852351.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04305"/>
    <dbReference type="EnsemblBacteria" id="KWX22088">
        <property type="protein sequence ID" value="KWX22088"/>
        <property type="gene ID" value="AFM11_21490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1646"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="409" mass="45787" checksum="52F7809FA15F8B0B" modified="2016-06-08" version="1">MNRPVLQGFTYDPFDPDVMADPLPYYRILRDEHPVYYIDKWDTYALSRFDDIWEVLGITDGTFVASEGTLPAATVLSHHNDGPVPDPPLHPMPFHANFDSPIYENVRRCTSAQFRPRAVPKLADRIRTLANERLDELLPRGRFDLTQDYAGIVAAAMVCEFVGLPAELAPEVLATVNAGSLAQPGEGVEVGNARPGYLSYLTPIVERRRAEGPDGSVPIADSLIGFRLPDGSALGDMEAAVQMLGVFIGGTETVPKITATGLWQLRRHPDQLAAVRADLDGNVPIAREEIIRHSAPAQWFARTVRRPYTIHDTTLKPGQRVITLLASAARDEREYDNPDAFIWNRPIERLLSFGRGQHFCLGVHVARLEITIMIQEWLKRVRDYHIDEQAASRPPSSFQWGWNNIPVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIC6</accession>
    <name>A0A132PIC6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852393.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04465"/>
    <dbReference type="EnsemblBacteria" id="KWX22109">
        <property type="protein sequence ID" value="KWX22109"/>
        <property type="gene ID" value="AFM11_21660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1680"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018988">
        <property type="entry name" value="DUF2000"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09391">
        <property type="entry name" value="DUF2000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="136" mass="14826" checksum="5B5A51EF1BDE98BB" modified="2016-06-08" version="1">MRFETKIAVLLRDDLEAWQRLNVCAFVASGIAAANPDTVGDPYVDADDTEYLAMFGQPVLVFEGSKETLRAAHTRALTRGVPMSIFTADLFATGNDRDNRAAVRAVARADLDLVGLAVHARRNVVDKILKGARMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ74</accession>
    <name>A0A132PJ74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Capsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852156.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22314">
        <property type="protein sequence ID" value="KWX22314"/>
        <property type="gene ID" value="AFM11_21005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1544"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024455">
        <property type="entry name" value="Phage_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05065">
        <property type="entry name" value="Phage_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01554">
        <property type="entry name" value="major_cap_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="276" mass="28533" checksum="580DD4F97913E635" modified="2016-06-08" version="1">MAVLNSNLQTAWTPEDYGQLIDTVIAEKSIAFQAGTRITTGSETWRTPMLTADPAVGWYAENTQIALTDPTTSELVVTPKAVKGLTQISTEAAEDSNPAAADQVGRALARAIAKKIDAAFFGNTIANGPNGLMSLVGVNVIDTGTITLDSLDPFHEAKAAALIDGATITHFVLAADVALALAKAKQATDSNMGLLADVSDGTTLAGVPVLVSTDVAAGEAWGLDASQIFVVQRTGTTVTRSFDAAFSFDAVQVRATARVAFGFANPAGVVRLHDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJA4</accession>
    <name>A0A132PJA4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19855</name>
        <name evidence="3" type="ORF">AWC31_11195</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX09041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851853.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22411">
        <property type="protein sequence ID" value="KWX22411"/>
        <property type="gene ID" value="AFM11_19855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09041">
        <property type="protein sequence ID" value="ORX09041"/>
        <property type="gene ID" value="AWC31_11195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1305"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453394" evidence="1">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="85" mass="8230" checksum="D7658E787348884F" modified="2016-06-08" version="1">MKALIGLAVGVLAASGIALATASPASAGCQGGWTPWGGGTTCDGPIAQDGTFQRCVTAGAMGFGGTNCYLLNVNNLAGNVPYVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJH5</accession>
    <name>A0A132PJH5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851929.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11465"/>
    <dbReference type="EnsemblBacteria" id="KWX22486">
        <property type="protein sequence ID" value="KWX22486"/>
        <property type="gene ID" value="AFM11_20250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1385"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="409"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="500" mass="53031" checksum="16D2BB54BD59135D" modified="2016-06-08" version="1">MNVLHELIAEAARTAPDRAALITDDGTTTGFAEFDRQIRSVAAWTASRTDPADRVAVIADNGAAYALLYYGVPRSGRVLTLINQRLSPAEQAAQLDATRPALVLGDAKYLSALGNTPDDSHLVTFDSAAWRDATTADPQYPDAAGPDDPAWLLFTSGSTGVPKGVVHSHRSILAAVRGTVAGRSVQPGGVYLLPFPMCHIAGYNMLVHHTTASTVVLTAQFRPEAFADLVRTHAVRSCSLAPTMLHSLLGHLERTGTRLPTLQAVAYGSAAMPLDLLRRAIDVLGVDFHQGYGMTETGGNITFLGPDDHRAGAAGDTRLLVSAGHPHRDVEVGIVGADGMPLAVGEVGEIVVRGDQVAPRYWPAQPSTTDGWLRTGDVGRLDTDGRLFVVDRLKDVIVTGGENVSSRAVEDVLSGHPDVDMVAVVGVPDDYWGEAVCAVVVPVAGREPSADELIEHVRCAIAGFKRPRVVLFVDALPLTGNGKVAKDRVREFARSAVLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJL2</accession>
    <name>A0A132PJL2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_22180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852572.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04940"/>
    <dbReference type="EnsemblBacteria" id="KWX22202">
        <property type="protein sequence ID" value="KWX22202"/>
        <property type="gene ID" value="AFM11_22180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1785"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="171" mass="18596" checksum="B3B6C1B077C35E32" modified="2016-06-08" version="1">MSEESTSNAASQTRLPKDVRHAELDDIDRRILLALHADARMSNSALADSVGIAASTCHGRVRRLQEIGVIRGFYTDIDPAAVGLSLQAMISVSLQSNARGKIRSFIAHIRKRPQVMDVYFLAGGDDFILHVAARDTDDLRAFVVENLNADADVAGTQTSLIFEHLRGASPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK22</accession>
    <name>A0A132PK22_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pribosyltran domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22537">
        <property type="protein sequence ID" value="KWX22537"/>
        <property type="gene ID" value="AFM11_20340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1401"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="681" mass="74959" checksum="212E2817227ACEFE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK92</accession>
    <name>A0A132PK92_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851078.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05070"/>
    <dbReference type="EnsemblBacteria" id="KWX22759">
        <property type="protein sequence ID" value="KWX22759"/>
        <property type="gene ID" value="AFM11_17550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.865"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="275" mass="28456" checksum="FA45286059F55C21" modified="2016-06-08" version="1">MPTDGPLTGKVAFITGAARGQGRAEAIRLAADGADIIAVDLCHQIASVPYPLATPDDLAETVKLVEDTGARIVAGQADVRDEAALASALQAGVDELGRLDIVVANAGIAPMQSGADGWRDVVDVNLTGVHHTVEVAIPTMVEQGDGGSIVLISSAAGLIGVGGGDRGSLGYTAAKHGVVGLMRAYANFLAPHSIRVNSIHPTGVDTPMINNEFTRQWLKHVAEELNAPTDFGNALPVQVVQVEDIANAVAWLVSDQARYVTGVILPVDAGIVNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK93</accession>
    <name>A0A132PK93_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851076.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05065"/>
    <dbReference type="EnsemblBacteria" id="KWX22758">
        <property type="protein sequence ID" value="KWX22758"/>
        <property type="gene ID" value="AFM11_17545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.864"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="141" mass="14505" checksum="DD70CA742DFB586C" modified="2016-06-08" version="1">MSPAAAVIVAVSFVWLGMVLAISFLEAPLKFRAPGVTLQIGLGIGRLVFRALNSVEILFAVAILIALAADPPATSVNVAIAVAVVALAVQLLAVRPRLTRRSDAVLSGSDAPRSHAHYAYVALEAVKVIALSTGGILLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKE3</accession>
    <name>A0A132PKE3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA_dh_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22805">
        <property type="protein sequence ID" value="KWX22805"/>
        <property type="gene ID" value="AFM11_17825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="1">
        <location>
            <begin position="216"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="35460" checksum="2B4BEB7CCB6E15E6" modified="2016-06-08" version="1">MRDRRATIMEDRVVTDKGVRMTEPRAARDAQAAGFLSAMGEPIAAVRDSPDLRILQPSGFGGGSGTVEQFIAAVVRLAREDGQAAWTAAAVNAAAFEIGGAPEPAGADVWGHARQALVTSAYRGAGRLTGADRVLSGRWPSVPAARWADWFVLPADDAGSACRVLVARRDVDIAPVAGPASAWAEVTVTGVAVAPHHVLESRSGASISAQVLLSAGMAAAVAGAADGAWCAHVAQMKERLATSHGGAEVADQAPSTVHVAHTACDIDAAILQITDAAHHADDLAAAVRAHRQAVARAREAADTLMSAGRRHALDAADPVCRLWGDVHAGARLAISLFDCLDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKJ2</accession>
    <name>A0A132PKJ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_18165</name>
        <name evidence="9" type="ORF">AWC31_12235</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851285.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12235"/>
    <dbReference type="EnsemblBacteria" id="KWX22856">
        <property type="protein sequence ID" value="KWX22856"/>
        <property type="gene ID" value="AFM11_18165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18755">
        <property type="protein sequence ID" value="ORX18755"/>
        <property type="gene ID" value="AWC31_12235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.990"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX18755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="434" mass="49178" checksum="0CA1FC0AD728F590" modified="2016-06-08" version="1">MYGSLVAATDSTTNRMSTGLLNAFRPRTSPPGIATVLRSVLWPVAILSIIHRSYVLATNGYITDDFGPVYRAVINFKLGLDIYNEHFEYVDPHYLYPPGGTLLLAPFGYLPVDASRYWFIFFNTVAIILAAYFLVRLFKYSFTSVAMPALLLAMFCTESVTNTLVFTNINGCILLCGVLFFRWLLAGGVRNELLAGVAIGLTLVVKPSLAPLLLLPLLNRQFYTFITALGVPVLFNAVAWPLVSDPMGFVRNTVPYILSTRDYFNSSILGNGIYYGLPMWLILLLRIVFLLLAVGSLWLLYRHYRERDPLFWMLTSSGVLLIASFLVLSLGQGYYSMMLFPFLMTVVLPNSVIRNWPAWLAIYGFMTMDRWLLGHWPTTGRFLEYMKITYGWSLMLVVVFCVLYFRYLDAKQDGRLDEGIDPPWLSRARATESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKK9</accession>
    <name>A0A132PKK9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851329.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12405"/>
    <dbReference type="EnsemblBacteria" id="KWX22876">
        <property type="protein sequence ID" value="KWX22876"/>
        <property type="gene ID" value="AFM11_18450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1024"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="656"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="792" mass="85406" checksum="15D40513FD800247" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKS4</accession>
    <name>A0A132PKS4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850592.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19975"/>
    <dbReference type="EnsemblBacteria" id="KWX22950">
        <property type="protein sequence ID" value="KWX22950"/>
        <property type="gene ID" value="AFM11_16345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.617"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="26327" checksum="D6907DB05175557F" modified="2016-06-08" version="1">MSYDPGGYPSVAVTVDLVALTIRDDELCALVIRRGEAPYAGQWALPGGFVRPDEDLDQAATRELVEETGLAAERLHLEQLASYGAPQRDPRMRVITVAYLGLAPDLPLPTAGGDAAGARWAPVAELSPGRLAFDHDRILADGIERARAKIEYTPLATTFCPDEFTVAELRRVYEIVWGTTLDSRNFHRKVTGADGFLVPTGHTTTRDGGRPAQLYRRGGLRLLHPPMMRAADMPERLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKV0</accession>
    <name>A0A132PKV0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12005"/>
    <dbReference type="EnsemblBacteria" id="KWX22923">
        <property type="protein sequence ID" value="KWX22923"/>
        <property type="gene ID" value="AFM11_17935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.942"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="348"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="472" mass="48821" checksum="55395018B90AFAE1" modified="2016-06-08" version="1">MLITPAPPAWAAGVCARNGKPLADGTYTTTSGFGPRGNSIHQGVDLAGSDGTDIFAAMDGTVAAAGPASGFGQWIVIDSQTRTGLVSTVYGHMYPDGVLVRQGAPVRAGDHIAEMGNNGQSTGTHLHFEYWEGGRLSHGQAVDPAFILSGQAVSANQSTAQQASSAADCRTGVLKPGLVPPAFVPWLLKAGVMCQGITAPLLAAQLEAENGFRHGPTAPVSSTGAQGPAQFMPGTWKTWGKDYDNSGPPPDVNSIADAVMSQGALMCENYRLCAAGVADGSLAGDPVALALAAYNAGFGAVQRNGGMPSGGEYTTQTQPYVYKIMQRAKAFEASPGLGGMPPESVPITGGPTTIVDAATEFKGKKWVWGGGGVDGPTRDGFDSPGLTYYAVVRGTGGKEVLPRTADEQWNVGKEIALAEVQPGDLIFSGWDRHDRPSHVGIALGNGEMIHADPARGVVIAEFYPESKARRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLI4</accession>
    <name>A0A132PLI4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_15435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850227.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16340"/>
    <dbReference type="EnsemblBacteria" id="KWX23215">
        <property type="protein sequence ID" value="KWX23215"/>
        <property type="gene ID" value="AFM11_15435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7202"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="326" mass="34893" checksum="7BBE1534AD08B4B2" modified="2016-06-08" version="1">MTALVVDDLSVDIRTITGTVRAVNNVSFSAERGETLALLGESGCGKSMTATALVGLLEPVADVVSGTAKLTGKDSEVDLFSADRKKRREIAGTELAIVFQDALTALNPLYTVGTQLAEPFRIHRGLSAKEAKRKAVELMARVGIPQPETRLNSYPHQFSGGMRQRLLIAMAVALNPSVLIADEPTTALDVTVQAQIMALLRDLRTEYDMAVVLITHDLALVAEEADRVAVMYAGQVVETGPVAEVFANPRHPYTKGLLNSVPVSAVRGETLKSIGGAPPDLHSIPAGCVYQDRCPLARDICITTRPALQGDGRRSACHFPEEVTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLV1</accession>
    <name>A0A132PLV1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850348.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15995"/>
    <dbReference type="EnsemblBacteria" id="KWX23273">
        <property type="protein sequence ID" value="KWX23273"/>
        <property type="gene ID" value="AFM11_15770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7277"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="BLACT_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="41"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="28468" checksum="B9D24D6366C789F7" modified="2016-06-08" version="1">MTAGAELQHPAYGLLRPVVETDTVSASVLLCNNPGLMTLEGTNTWVLRAPASDEMVVVDPGPDDDEHIARVAELGKISLVLISHKHEDHTGGIDKIVDRTGAVVRSVGSGFLRGLGGPLTDGEVIEAAGLRITVMATPGHTADSLSFILDDAVLTADTVLGRGTTVIDSEDGSLRDYLDSLHRLKGLGARTVLPGHGPELDDLEAVAAMYLAHREERLDQVRGALRDLGEDASARQVVEHVYTDVDQKLWDAAEWSVQAQLDYLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM16</accession>
    <name>A0A132PM16_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16280"/>
    <dbReference type="EnsemblBacteria" id="KWX23227">
        <property type="protein sequence ID" value="KWX23227"/>
        <property type="gene ID" value="AFM11_15505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7216"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="113" mass="12099" checksum="7251FE63E88A4136" modified="2016-06-08" version="1">MTTAEWDALPHTITTFMTALDAREVDQTLATLAPDAVVTDEGHDYTGHDQIGKWVATAAAEYTYTAEITGATTTDTGVVVTQHLKGDFPGGVADLNYRFTLDGALISRVVIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PME2</accession>
    <name>A0A132PME2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14640</name>
        <name evidence="2" type="ORF">AWC31_18260</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849891.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23506">
        <property type="protein sequence ID" value="KWX23506"/>
        <property type="gene ID" value="AFM11_14640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17258">
        <property type="protein sequence ID" value="ORX17258"/>
        <property type="gene ID" value="AWC31_18260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7037"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX17258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="105" mass="11343" checksum="371FDCBE149C3BD1" modified="2016-06-08" version="1">MSLKADLDQMRTVGGHLRGLAVEVTGMKFGPMMMGTDSAALKSVGAMQNIQYNVLNTTLIPTCSERLSETGDIMINIADKFQNGDESKLLDVVNTFNKATGTWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PML4</accession>
    <name>A0A132PML4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-beta-D-heptose 1-phosphate adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_14200</name>
        <name evidence="6" type="ORF">AWC31_09200</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849746.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09200"/>
    <dbReference type="EnsemblBacteria" id="KWX23437">
        <property type="protein sequence ID" value="KWX23437"/>
        <property type="gene ID" value="AFM11_14200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09125">
        <property type="protein sequence ID" value="ORX09125"/>
        <property type="gene ID" value="AWC31_09200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6946"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="255" mass="27104" checksum="E2A5F2808CF3F47A" modified="2016-06-08" version="1">MYAEERQQAIAELVMSRGRASVAELAQTYDVTTETVRRDLAVLDKAGVLRRVHGGAVPVRNLHLVEAGVGERDTTRAEQKDAIAAAAIDFFPLSGATVLLDAGTTTARVAAEIPSDRELTVVTNSVPIAGRLAAMPTVTLQLLGGRVRGLTQAAVGEQVLRALDTMRVDIAFIGTNAISVRHGLSTPDTEEAAVKRAMVRAANYVVVVADSSKVGQEDFVSFAPLDSVDTLITDAEIDETDRKQLTEQGVEVVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMP2</accession>
    <name>A0A132PMP2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17980"/>
    <dbReference type="EnsemblBacteria" id="KWX23610">
        <property type="protein sequence ID" value="KWX23610"/>
        <property type="gene ID" value="AFM11_14920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7095"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022480">
        <property type="entry name" value="F420_MSMEG2906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03856">
        <property type="entry name" value="F420_MSMEG_2906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="28145" checksum="31F742D4E543D59B" modified="2016-06-08" version="1">MQLQPQHSPQYSHIRDAVRRCEDIGVDIAFNWDHFFPLYGDPEGAHYECWTMLGAWAEQTSRIEIGALVSCNSYRNPELLADMARTVDHISDGRLILGIGSGWKQKDYDEYGYEFGTAGSRLDDLAEALPRIRARLAKLNPAPTRDIPILIGGQGERKTLRLVAEHAGIWHAFVDRNTYPGKAQVLGEHCQSVGRDPATVERSAGVQDSGGIDAMLAEADALADLGVTILTVGANGPDYDLTAAEALCRWRDGRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMQ2</accession>
    <name>A0A132PMQ2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23477">
        <property type="protein sequence ID" value="KWX23477"/>
        <property type="gene ID" value="AFM11_14445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6998"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="799"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="868" mass="91621" checksum="0A2FEC9BD7FD0B9A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMR6</accession>
    <name>A0A132PMR6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_14360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850074.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23593">
        <property type="protein sequence ID" value="KWX23593"/>
        <property type="gene ID" value="AFM11_14360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6980"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="4">
        <location>
            <begin position="38"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="5">
        <location>
            <begin position="189"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="322" mass="34938" checksum="E88522314360A82B" modified="2016-06-08" version="1">MSNTDTAPAEVTCATSAFTGVLHAREVPLGGPRALLVRRTLPQRERSLIGAWCFADHYGPHDVRASGRGMDVPPHPHTGLQTVSWLFAGEIEHRDSAGVHAMVRPGELNLMTAGAGICHSEVSTADTAVLHGVQLWVALPDSDRDTGRDFAHYAPTPRTFDGATLRVFLGELADSRSPVHTFTPLLGAQIDLEAGAVLTLDVDPAFEHGVLLDQGMVQVGDTPLEVADLAYQAPGHQLLHLANPADSPARVVLLGGPPFPEELVMWWNFVGRSHDDIAMYRELWQDHDARFGDVSGYRRDTARLPAPPLPNGRLKPRPRPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMU0</accession>
    <name>A0A132PMU0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_15130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23584">
        <property type="protein sequence ID" value="KWX23584"/>
        <property type="gene ID" value="AFM11_15130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7138"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="3">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="243" mass="26972" checksum="EF5C12E02EEEEC27" modified="2016-06-08" version="1" fragment="single">PRVEAAKLDTAMQSHHDAQIADWKRDHENCEQAPPFPNTVDAFMSLVEAGWDSDVAARPHGQHTTVVVHLDVDKRVAALHLGPLLTDEERQYLTCDATCEAWFEQHGHVIGAGRTTRTVNRRLRRALEHRDRCCVVPGCGATRGLHAHHIIHWEDGGLTELTNLVLVCPHHHRSHHHGEITITGPAHKLIVTDHAGQPLRGGSLAQPPTTPPPAVPPCPGPTGERADWWWYEPFQPQPPPTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMW3</accession>
    <name>A0A132PMW3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849107.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23679">
        <property type="protein sequence ID" value="KWX23679"/>
        <property type="gene ID" value="AFM11_12850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6663"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="304" mass="33714" checksum="678AEDB8B3A08AA0" modified="2016-06-08" version="1">MELRQLRYFVTVAEEMNFRRAAERLLIAQPALSQQISKFEKELRTALFERTTRRVELTDAGRVLLAEGRRVLAEADHALAAVQQAAHGEVGLLRIGFVSSAALRIVPATVRALQKAWPGVQVELSEATTDRQLTAIADGALDIGIVREVDRFEGIVVRPLMREPLIVAMHSSHPLAHRTSVRIADLRNERFLTFPRQQVSRLYDHIAALCHQAGFRLEAAQEAIQFPTLLGLAAANTGVTIVPESLRALHLPELRYVTLADPQAVSTVSVAYRADRRHIPAITHFLDIASVDLTDPESQDPEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMX4</accession>
    <name>A0A132PMX4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849027.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02960"/>
    <dbReference type="EnsemblBacteria" id="KWX23653">
        <property type="protein sequence ID" value="KWX23653"/>
        <property type="gene ID" value="AFM11_12680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6626"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="1">
        <location>
            <begin position="42"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="429" mass="44587" checksum="8F5E9BD985C53492" modified="2016-06-08" version="1">MPSTDQTPKADQPLYGQQTILALANFTAPGRTFGDVPAFVRNYALVKLAAAQANHSLGVLGSAQRDGIVAACEEVAAGHHADQFPSALLLGGGGTTTNMNVNEVIAARASQLAGAEVHPNDHVNASQSTNDTYPTAMALTVLDLVEHPVQALDELARALDDKAAEFDVTPHLGRTCLRDAVTLTAGQSHRAQSAAIRRTCEDLRSATAAMSSVPLGATAIGTGVGAPDGYRELAIGELVSLTGRQLEPAVDPFDALAHLDPYAAVAAAGARAGLTMAKVAADIRLLSSGPAGGLGDLNIPAVQAGSSIMPAKVNPAIPEYVMQLSYRIRGAAHTVEFAVAAGELELNVMEPVIIDALITIFDDLAAAATTFARRCVSGISWDGQRREENLSAALDSWVTLAAARGYDAATLRYRNNDLSTSGLNGDRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN16</accession>
    <name>A0A132PN16_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-ACP thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_13160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849258.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03445"/>
    <dbReference type="EnsemblBacteria" id="KWX23730">
        <property type="protein sequence ID" value="KWX23730"/>
        <property type="gene ID" value="AFM11_13160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6725"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="273" mass="31442" checksum="C2C622E7C68D63ED" modified="2016-06-08" version="1">MTGTAGKPTTGLGKTMMPVPDPHPDVFDRQWPLRVGDINRVGRLRFDAACRHIQDIGSDQLREMGFEETHPLWIVRRTMIDLIRPIEFQDMLRMRRWCSGTSNRWCEMRVRIDGRKGGLMESEAFWININRETQGPARISDDFLEGLRRTTDEARLRWKAYLKAGSRDDADEIREYPVRVSDIDLFDHMNNSVYWTVIEDYLHTHPELLERPLRVTIEHDAPVALGDKLEIISHTHPPGSTDKFGPELTDRTVTTLTYAVGEETKAVAALFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN93</accession>
    <name>A0A132PN93_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849472.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03925"/>
    <dbReference type="EnsemblBacteria" id="KWX23811">
        <property type="protein sequence ID" value="KWX23811"/>
        <property type="gene ID" value="AFM11_13680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6832"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="338" mass="36145" checksum="890C90A2174B4E99" modified="2016-06-08" version="1">MIDLLVAGGGPAGLATAVYAARAGLEAVVVEHRRGPIDKACGEGLMPHSVRQLERLGATVEGKDFYGIRYLDGRRCAEARFRDGAGRGVRRTVLHAALSEAAAAAGVRVVHGEVGEVTQDSTSVSAAGFRARYLAAADGLHSPIRRSLGLASGDAQRRRWGIRRHVQTAPWSDCVEVYWAHDTEAYVTPVNDDCVGIAILKSTRGGFGEHLEQFPELAERIDGLPHGQDRAAGPLRQKVRHRTAGRVLLVGDAAGYIDALTGEGMGLAFGAAELLVGCVLADRPQDYDRQWRAMTRRYRFLTAALLHGSGFRPVRAAITPAAAALPSVFTRVVNALGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNX9</accession>
    <name>A0A132PNX9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_11790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848430.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24040">
        <property type="protein sequence ID" value="KWX24040"/>
        <property type="gene ID" value="AFM11_11790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6437"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="215"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="276"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="493" mass="52769" checksum="3CE9091EC1138EB7" modified="2016-06-08" version="1">MSSMPRTPAARSRLRRLLPSTARTRIIAWMLLLVLAALGIVTFVTWRLLVSGIDTRIDEALRFEVSEFTELTAPGVNPRTGEPFTSVDEVIREAIAYNLARPNEKFLGYVDGEYRTQSRQEPGTPEVLASDPGFTALVASLTAPTDGNYAHPEAGDVRYLAIPVRLDGDPGHGVIVAAYLSDAERDSADDAARLMLIVGAITVLGAAGAAWLVAGRILRPLRDVVDTARTITENDLSQRIPSSGEGDELDALVGTVNGMLDRVEAGVSAQRRFIDDIGHELRTPITIVRGHLEVLDPGDRADVESTVALVDDELDRMNRMVADLLLLARAEQPAFLQPVPVDVGALTADAFGKVSRLGDREFTFDACARVVAVLDPQRITQALVALADNACRYTKPGDRIGIGSQLSGGWLRFWVSDTGPGVSEADRSRIFERFGRGSAGGRRSDGAGLGLAIVRAIAVAHGGEVLLDTVVGQGATFTVVIPAIPEEAPWPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPD4</accession>
    <name>A0A132PPD4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aspA</name>
        <name evidence="3" type="ORF">AFM11_11125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848836.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24165">
        <property type="protein sequence ID" value="KWX24165"/>
        <property type="gene ID" value="AFM11_11125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6302"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="2">
        <location>
            <begin position="414"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="476" mass="50004" checksum="30B13DC2E197B35A" modified="2016-06-08" version="1">MHAASTPGDRIESDFLGERRVPARVYWGVHTARALENFPISGIPISAHRSLIAALGAVKQAAVRANLDLGLIDAEMATVIDRACQEVRDGLLDAEFVVDVVQGGAGTSTNMNANEVIANRALELRGLPLGSYDQINPNDHINRSQSTNDVYPTAVKVALLFTLDEMAAALGRLGDAFAAKAEEFRGVVKIGRTQLQDAVPMTVGQEFGSWAANLVEEQARISDTCALLREVNLGATAIGTGITTVPGYGAAVTQHLREITGLPLVSAPDLVEATSDTGSFVQLSGVLKRIMVKVSKICNDLRLLSSGPYAGLGELRLPPRQAGSSIMPGKVNPVIPEVVNQVAFAVVGNDITVTMAAEAGQLQLNAFEPVICHSLLQSISWMTRAFESLTTRCVAGIQINRERLLALSAGGTGVVTALAPYLGYAVASQIASAVAAGRGDLRNLVLETGLVDPDRLDELLEPGTLAAGSNNAASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPJ1</accession>
    <name>A0A132PPJ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847245.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05525"/>
    <dbReference type="EnsemblBacteria" id="KWX24258">
        <property type="protein sequence ID" value="KWX24258"/>
        <property type="gene ID" value="AFM11_09700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5978"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="170"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="324" mass="33904" checksum="C6DD778B3772C73B" modified="2016-06-08" version="1">MSGQLRFGLIGTGWIGRFHAESLARRVPDACLVAVADPNIEAAQAIGASQTYADPQELIDDPAVQAVAISSPAAAHTDLVVAAAQAGKHVFCEKPMALTLDDADRAIAAAADAGVALQVGFNRRFAADFAAAHDAIIAGTIGTPQLLRSLTRDPGISAEVAARVKPWTIFNETLIHDFDTLCWLNPGARVTEIYAQAAALIHPQFAEAGFLDTSVVQLRFDNGAFGTAEASFQAVYGYDVRGELFGSDGVLLAGRAPEQAGRLNIELFADAYVAQFAHFVDSIRTGTTPSVTGHDARVALEIALAAAESVRTGAPVALAGAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPV4</accession>
    <name>A0A132PPV4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermidine/putrescine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847600.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18825"/>
    <dbReference type="EnsemblBacteria" id="KWX24369">
        <property type="protein sequence ID" value="KWX24369"/>
        <property type="gene ID" value="AFM11_10390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6117"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453485" evidence="2">
        <location>
            <begin position="24"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="396" mass="43058" checksum="25890660909A380B" modified="2016-06-08" version="1">MKWPALHTGLVLAACATLVVACAGSQSPGGESGSPPELEPPSAVGDGEGQLNLVAWAGYAEDGSNDKAVDWVTPFEQQTGCQVNVKIGNTSDEMVQLMRSGQYDGVSASGDATLRLIYAGDVAPVNTDLVPNYETISSFLKDQPWNSVDGQMYGIPHGWGANLLMYNVNVVRDAPNSWAAVFDDASKYKGKVTAYDSPIYIADAALYLSKTKPELGITDPYSLTSEQLDAATELLKAQRENIGEYWSDYTKEVQAFESGTSVIGTSWQVIANTIGADNKVQVNTVLPKEGSTGWSDTWMVSAKAAHPNCMYKWMNWISSPEINAQVAEYFGEAPAQTKACEHTTQKDFCDIYHATDAEFASRIHYWTTPQTQCVDGSGDDCTAYSEWVDKWQQIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ90</accession>
    <name>A0A132PQ90_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_10575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847966.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19010"/>
    <dbReference type="EnsemblBacteria" id="KWX24499">
        <property type="protein sequence ID" value="KWX24499"/>
        <property type="gene ID" value="AFM11_10575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6155"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="28"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="490" mass="51934" checksum="7AF200B4C848CE0F" modified="2016-06-08" version="1">MQETPTIADVRQADRRLLIGGALRDTPRTFPSINPATGDVLGYAPDATVADAEAAVAAARDAFDNTDWSTNTELRIRCLEQFHQALIDHRDELAALTIAEVGATAALCAGAQLDQPIDIVRYYAELLKTYPMTEDLGNIESRGAQHHRWVEKEAGGVVAAIIAYNYPNQLALAKLAPALAAGCTVVLKSAPDTPLITLALGELIANHTDIPAGVVNVLSGADPEVGAVLTTSPDVDMVTFTGSTPTGRRIMAAASETLKKVFLELGGKSAAIVLDDADFNTAALFSAFSMVTHAGQGCALTSRLLVPAKHKDEIVELIKNNFGLVRYGDPADPKTYMGPLISEKQRDKVDGMVKRAVEAGATLVTGGEKVEPGFFYTPTLLADVDPDSEIAQEEVFGPVLAVIAYEDDDDAVGIANNSIYGLSGAVFGSEDRALAVARRIRTGTFSINGGNYFSPDSPFGGYKQSGIGREMGKAGLEEFLETKTFARVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQC5</accession>
    <name>A0A132PQC5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846015.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22075"/>
    <dbReference type="EnsemblBacteria" id="KWX24538">
        <property type="protein sequence ID" value="KWX24538"/>
        <property type="gene ID" value="AFM11_07575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5363"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="410"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="500" mass="54024" checksum="306A57519D415E39" modified="2016-06-08" version="1">MVHTTLADALTDAARNTPGRVLLIDGDVELGCRELSDRATALAGHMARQMPAGSVVSFMLPNWHEAAIIYLAATLAGMVANPILPSLRDHELRFILEDADSRMIFIPERFGQHDYAGMLTRVCADMASPPDVVVVRGHSHIAFDGLGNAPAGTLPALDPDTVRMILYTSGTTGRPKGVLHSHKSINALIYQLRDHWLIEPCDTFLVPSPIAHIGGSIYAFECPLLLGTTAVLMQRWNADDGVELMTEHRCTHMAGATPFLEQLLNAAERAGTRLPDLKVFICGGASVPPSLIRRASGYFERALVSRVYGSTEVPVTTVGSLRPGDVDHAAETDGRPGVAEIRLVSGEIRARGPQMLLGYLHPEDNADSFDAQGFFRTGDLGRWVDGDYLTVTGRAKDLIIRNGENISPKEVEDILVGELGIAEIAVVGVPDDRTGERACAVIVPADDRRPDVAALGKVLEKAGVAKFKTPEQVEIWEALPKNDAGKVLKHQIRATLTKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQI4</accession>
    <name>A0A132PQI4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_07555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846003.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22055"/>
    <dbReference type="EnsemblBacteria" id="KWX24534">
        <property type="protein sequence ID" value="KWX24534"/>
        <property type="gene ID" value="AFM11_07555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5359"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="34"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="447" mass="51015" checksum="B68CB0669A6F8EBC" modified="2016-06-08" version="1">MTEELADPMAIDVDAYISPEYARAERDRLWRKVWQQVGRVEDIPEIGSYLTYDILDDSIIVVRTGPNEFAAHHNVCMHRGRRLIDTPKGAKNACARTRKSFVCGFHGWTYDFNGACTHIREQDDWKGALTPQNTHLPPVTVDTWGGWLFINMDTDPEPLADYLFPAAKILDPFGLENMRYKWRKWLYFDCNWKVAMEAFNETYHVFTTHPEFNRFGEFKGWAKAQGRHSNIGYDAPKGMDETKSKIRLGTGDPRISTAEMQVYTMEETNATTTQTLVNAAKRLVDELPEGTPADKVLEHWLSSARRDDEARGVIWPTIPADILGQSGTAWQIFPNFQIGQGLTSALCYSARPDPSYNPDKCIFEVSVFELYPKGEEPQTEWQYTPADSPNWLSVLPQDFSNMAAVQQGMKSMGFPGTKPNPYRERSTVNLHYQLSKYMGVGEPREIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQL4</accession>
    <name>A0A132PQL4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_07715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846088.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24340"/>
    <dbReference type="EnsemblBacteria" id="KWX24564">
        <property type="protein sequence ID" value="KWX24564"/>
        <property type="gene ID" value="AFM11_07715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5392"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="25913" checksum="8783651AF5C0EF30" modified="2016-06-08" version="1">MSQLSPEPDADEDEQRPPAITARALTMHGPWGPVYGPIDLDIAEGGVTVLVAPSGSGRTALLMTLAGRMRPAGGALTVFGRTRARDIFRAAALAGIDEIDTVSESVTVRDLITEQRRWDAAWYRLVRRADENDLAALCAPVFGDLPLPPLTEYFDALTELDQILLRVALANTARPPLLVVGNLDHLTDDRNRILLLDRLVALGEQQTVITANVNGVANPAVTQLTVPNTTPAELAAAQKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQM9</accession>
    <name>A0A132PQM9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08135</name>
        <name evidence="2" type="ORF">AWC31_00060</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000001">
        <property type="protein sequence ID" value="ORX19293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846300.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00060"/>
    <dbReference type="EnsemblBacteria" id="KWX24636">
        <property type="protein sequence ID" value="KWX24636"/>
        <property type="gene ID" value="AFM11_08135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19293">
        <property type="protein sequence ID" value="ORX19293"/>
        <property type="gene ID" value="AWC31_00060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5478"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX19293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="114" mass="12176" checksum="AB37AB0EE8EECC2A" modified="2016-06-08" version="1">MEKISLTALARQQLASARTANSGRSAHTVYGGHEHALRQTLIALTQGSGLDEHESPGEATLQVIEGRVRLANSEASWEGSPGDHIVIPRTRHTLHALADSVVLLTVVKTMGPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQN4</accession>
    <name>A0A132PQN4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_07835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846146.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24445"/>
    <dbReference type="EnsemblBacteria" id="KWX24584">
        <property type="protein sequence ID" value="KWX24584"/>
        <property type="gene ID" value="AFM11_07835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5418"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="44"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="357"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="392"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="643" mass="70497" checksum="B79D2CA24777E410" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR56</accession>
    <name>A0A132PR56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846891.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24828">
        <property type="protein sequence ID" value="KWX24828"/>
        <property type="gene ID" value="AFM11_07410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5332"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012853">
        <property type="entry name" value="CPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007531">
        <property type="entry name" value="CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR007531-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR007531-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="191" mass="20978" checksum="725F46586F1A3EFB" modified="2016-06-08" version="1">MVSAAEIGQVVLLNGVSSSGKSTLARQLLADFATPWFHMSVDMFGAMRAQAQTHDLDDASLTEVLRRTRAGFHRAVRAMALAGNNIVMDHVLSEPWRLTDLLTVMADVDVVFIGVHCDAAVLMDREVARGDRPIGTAATQIQPTHHHGLYDVEVDTSAEDAQACSARIRQYLEQHPAPAVRAFHVLRRSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR90</accession>
    <name>A0A132PR90_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24849">
        <property type="protein sequence ID" value="KWX24849"/>
        <property type="gene ID" value="AFM11_08620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5575"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="130" mass="13796" checksum="351F24BA72939C32" modified="2016-06-08" version="1">MAALALSGCAWFGGDGERDRFVQPGSPKVSPSGHYTAAVDTRAARSGVGTWVAVIIDESGAEVFRDDYAYSTRHGAGITWLSTDDQLWLLSGDVGTAHVDRGSDGRWSKTAVTPETRGSVPAEIRELIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRD2</accession>
    <name>A0A132PRD2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic acid reductase</fullName>
            <shortName evidence="3">CAR</shortName>
            <ecNumber evidence="3">1.2.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ATP/NADPH-dependent carboxylic acid reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">car</name>
        <name evidence="6" type="ORF">AFM11_05390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP- and NADPH-dependent reduction of carboxylic acids to the corresponding aldehydes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a carboxylate + ATP + H(+) + NADPH = AMP + an aldehyde + diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:50916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
        <text evidence="3">Binds 1 phosphopantetheine covalently.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The N-terminal domain likely catalyzes substrate activation by formation of an initial acyl-AMP intermediate, the central region contains the phosphopantetheine attachment site, and the C-terminal domain catalyzes the reduction by NADPH of the intermediate thioester formed from the attack of the phosphopantetheine thiol at the carbonyl carbon of acyl-AMP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family. Carboxylic acid reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844975.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12765"/>
    <dbReference type="EnsemblBacteria" id="KWX24883">
        <property type="protein sequence ID" value="KWX24883"/>
        <property type="gene ID" value="AFM11_05390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4267"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02247">
        <property type="entry name" value="Carbox_acid_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046407">
        <property type="entry name" value="CAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 3 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="650"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="412"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="502"/>
            <end position="505"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="782"/>
            <end position="785"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="819"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="849"/>
            <end position="850"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="875"/>
            <end position="877"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="915"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="951"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="955"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3 4">
        <location>
            <position position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1169" mass="127093" checksum="72D6E286BCE3B8E4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRN4</accession>
    <name>A0A132PRN4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845116.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11695"/>
    <dbReference type="EnsemblBacteria" id="KWX24955">
        <property type="protein sequence ID" value="KWX24955"/>
        <property type="gene ID" value="AFM11_05835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4358"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="251" mass="27530" checksum="15ACFEA7C17381B4" modified="2016-06-08" version="1">MSQPDAQPVSLPVRRPRADRARQVADVLRHQIYDGAYDRGLPAESDLAAEFFVSRNTIREALAVLKNEGLIERGTKVGTHVAVRKFDHGLDALVGLKETFKDYGEVRNEVRAVQRLAAPPAVARKLALEPGAQVVFVERLRYLGDLPLSLDLTYLAPDIGEAVIAFSLETNDVFALIERVSGQRLGGATFALEAVSADPHSAATLQVPNGSALLMAERLTSLDDGRPVDLEYIRMRGDRITMRGNLFRSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRU6</accession>
    <name>A0A132PRU6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_06385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845287.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29290"/>
    <dbReference type="EnsemblBacteria" id="KWX25053">
        <property type="protein sequence ID" value="KWX25053"/>
        <property type="gene ID" value="AFM11_06385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4471"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="228" mass="24352" checksum="14192F990E1DC778" modified="2016-06-08" version="1">MPTDIDLLRTACERDLGDPEQWLSSISYPNSLALCVIDAIYSTGARYVTVEKVVGRYRDHRTAQGGDADSDGLTELLATMRELGGPDPWASQIGNRRPTSSAANAPLKAQAIAEVAEALVALGIDTTDDLRAVAADDERRARARAVWCATPGQRSGLTWDYTLKLAQIPGANAGPVVVGYVAREIGTVDSAGAAELIRGVAEAAGWNAIELDHAIWRFESGRPHQRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSB0</accession>
    <name>A0A132PSB0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_07150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17565"/>
    <dbReference type="EnsemblBacteria" id="KWX25185">
        <property type="protein sequence ID" value="KWX25185"/>
        <property type="gene ID" value="AFM11_07150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4628"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453542" evidence="6">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="280" mass="28903" checksum="459957CD856D0AB7" modified="2016-06-08" version="1">MLIRRIARPMLSATFIARGVDALRSPKPAADAARPTLGALSMLPAPVGPNVPTNAETVARVNGMVQVAGGLLLATGRLPRLTAAALALSVVPGSLGAHSFWKETDPQRAADERKAFLTDVSLIGGLIIAAADTAGKPGLAWRGRHAAQKVTATVAAALPAGAAASDSLADNPVVEKIGHGLAVGAERGRELADVARERASELAQVAREHAPELAEAARERGAAIADVARERGGVLADAARERGAVLADVARERGPELAETARERSAALADRARSQLDQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSJ4</accession>
    <name>A0A132PSJ4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_03005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843805.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25280">
        <property type="protein sequence ID" value="KWX25280"/>
        <property type="gene ID" value="AFM11_03005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2469"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="113"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="174"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="394" mass="42474" checksum="2D12878CC26C48EE" modified="2016-06-08" version="1">MNGKRKTTIRLRLTALYAGAFFICGAILIAAVYLNVQQSLQHPPGTGMQETVGRFLGNRGTGDHPVADRIFAAVNEQATQERAETLRALLVRSLVALVVMGVAAAGLGWLLAGRVLHPLQQITATARRVADRSLHERIALDGPFDEIKDLADTFDAMLERLDRSFDGQRRFVANASHELRTPLAINRTLIEVALDDPDTSESTRQLGATLLGVNARNERLIDGLLVLASSQQQLDLRPGVDLAQIAQRAIEIASPVAERSGVTIASQLQPVNVTGDLTLLERVAHNLIDNAVRYNLAEQGWVHVTVGATGPFARLIVENSGSVIAPGDVDDLFEPFRRLPNSERVSDPRLGPGRGAGLGLSIVRSVVQAHRGEVEARAHTTGGLTVTVTIPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT17</accession>
    <name>A0A132PT17_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fis family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_04300</name>
        <name evidence="6" type="ORF">AWC31_20855</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844458.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20855"/>
    <dbReference type="EnsemblBacteria" id="KWX25479">
        <property type="protein sequence ID" value="KWX25479"/>
        <property type="gene ID" value="AFM11_04300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16493">
        <property type="protein sequence ID" value="ORX16493"/>
        <property type="gene ID" value="AWC31_20855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2738"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX16493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="228" mass="25362" checksum="C426D62E81774E19" modified="2016-06-08" version="1">MTVKTRVLVIDDEPQILRALRINLSVRGYEVRTAATGAEALRSAADHRPDVIVLDLGLPDMSGIDVLAGLRGWLSAPVIVLSARTDSSDKVEALDAGADDYVTKPFGMDEFLARLRAAVRRATVTESDQPVIETSSFTVDLAAKKVTKNNAEVHLTPTEWGMLEMLVRNRGKLVGREELLREVWGPAYAKETHYLRVYLAQLRRKLEDDPSHPVHLLTEAGMGYRFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT48</accession>
    <name>A0A132PT48_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-ACP desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_07370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845752.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17350"/>
    <dbReference type="EnsemblBacteria" id="KWX25222">
        <property type="protein sequence ID" value="KWX25222"/>
        <property type="gene ID" value="AFM11_07370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4674"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="308" mass="34483" checksum="E8F0D8133B3F1679" modified="2016-06-08" version="1">MVTIQDAVLTELEPVVEANLNRHLGQAKPWNPHDYVPWSRGRDFALLGGEDWTPEDSQLDEVAKAALVVNLLTEDNLPSYHREIAVRFGLDGPWGQWVGQWTAEEGRHSIAIRDYLVVTRGVDPDALERLRMQHTVAGYDSGDKTVLEALAYVSFQELATRISHRNTGRAAGCPIAEQMLTRIAADENLHMVFYRNLVAAALDVAPNATMEAVANEVINFQMPGNTMPGFAENALTIAKAGIYDLRSHLDDVLRPVLRFWKIFEREDFTGEGARARDQLGQFLELVNAKASYYEQRRIERDAVAAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTG2</accession>
    <name>A0A132PTG2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="6" type="ORF">AFM11_05160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844759.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20080"/>
    <dbReference type="EnsemblBacteria" id="KWX25621">
        <property type="protein sequence ID" value="KWX25621"/>
        <property type="gene ID" value="AFM11_05160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2913"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="356" mass="38559" checksum="2242079A90BC55D0" modified="2016-06-08" version="1">MSLNLGIVGLPNVGKSTLFNALTRNNVLAANYPFATIEPNEGVVPLPDPRLDELAKMFGSEKIVPAPVTFVDIAGIVKGASEGAGLGNKFLANIRECDAICQVVRVFTDDDVTHVDGRVDPKSDIEVIETELILADMQTLEKALPRLEKEARTHKDRRPVYDSAVAAQEVLNSGKTLFGARFDAAVLRELNLLTTKPFLYVFNADEPVLTDEKRKSELRELVAPADAVFLDAKIEAELLELDDESAAELLESIGQTERGLDALARAGFHTLKLQTYLTAGPKEARAWTIHQGDTAPKAAGVIHTDFEKGFIKAEVVSYDDLVAAGSMAAAKAAGKVRMEGKDYVMADGDVVEFRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTK5</accession>
    <name>A0A132PTK5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844859.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21645"/>
    <dbReference type="EnsemblBacteria" id="KWX25671">
        <property type="protein sequence ID" value="KWX25671"/>
        <property type="gene ID" value="AFM11_03505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2575"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="584" mass="60662" checksum="1AD40C848F167F77" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTK9</accession>
    <name>A0A132PTK9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mce associated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844810.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20030"/>
    <dbReference type="EnsemblBacteria" id="KWX25645">
        <property type="protein sequence ID" value="KWX25645"/>
        <property type="gene ID" value="AFM11_05310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2948"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="196" mass="21263" checksum="429F8C98647F7567" modified="2016-06-08" version="1">MADESPDDESVESPEDEDTAVETADDEAEPEPEARPMSRIRLGALVGSAVVVVLAGLAGWLGYLAYQSQSAERHRDMMLEAGRQAAFSLTNVGWETADADVQRVLDSAGGKFYDDFEKRAESYREVVKQVKSKSEGTITGSALESISDGQAKVLVSVTVKSSNAGVPEQAPQYWRMVLTVQENEGKAKVSELEFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU48</accession>
    <name>A0A132PU48_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="10" type="ORF">AFM11_00820</name>
        <name evidence="11" type="ORF">AWC31_33860</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842438.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33860"/>
    <dbReference type="EnsemblBacteria" id="KWX25869">
        <property type="protein sequence ID" value="KWX25869"/>
        <property type="gene ID" value="AFM11_00820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11669">
        <property type="protein sequence ID" value="ORX11669"/>
        <property type="gene ID" value="AWC31_33860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.170"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX11669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="139" mass="14692" checksum="F496CD6463EF3219" modified="2016-06-08" version="1">MPPAKKAAGTAAKRGKTTRRREKKNVPHGAAHIKSTFNNTIVSITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENAARKAQEHGVKKVDVFVKGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU67</accession>
    <name>A0A132PU67_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_00940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33970"/>
    <dbReference type="EnsemblBacteria" id="KWX25889">
        <property type="protein sequence ID" value="KWX25889"/>
        <property type="gene ID" value="AFM11_00940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.194"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="128"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="188" mass="21599" checksum="18279D87D4750D0C" modified="2016-06-08" version="1">MVLSRDGLLEWLSDEVLARRAQRGDLEAFDTLVVRHAPALRRFVANTYPDRHECDDIVQETFIAAWKALPTFAFRSQFRTWLYSLASRRTVDALRRRRPQSDLDAAAETPDLGPGPGQRALDGDFMTALNRELSRLPYPGRAAWWLREVYDLPLSEIATVLHTTEGSVRGHLQRTRKRLAEALEEFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUA1</accession>
    <name>A0A132PUA1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP:cob(I)alamin adenosyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cobalamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00965</name>
        <name evidence="2" type="ORF">AWC31_33995</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842516.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33995"/>
    <dbReference type="EnsemblBacteria" id="KWX25893">
        <property type="protein sequence ID" value="KWX25893"/>
        <property type="gene ID" value="AFM11_00965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11693">
        <property type="protein sequence ID" value="ORX11693"/>
        <property type="gene ID" value="AWC31_33995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.199"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="132" mass="13207" checksum="B3342FEBEBE04D3A" modified="2016-06-08" version="1">MTSLPLATAQKVLDAAISKADEIGQPMNIAVVDDGGHLVAFVRMDGAIKASIDISIRKARTSVMMNLPTSALTTVCQPGGELYGLEQTAGGLVVFGGGILLEADGEVIGAIGVSAGSVEQDVAVAEAGVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUB7</accession>
    <name>A0A132PUB7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF222 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844805.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25642">
        <property type="protein sequence ID" value="KWX25642"/>
        <property type="gene ID" value="AFM11_05295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2945"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF222" evidence="1">
        <location>
            <begin position="50"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="465" mass="50116" checksum="9C742BD451EFB0B4" modified="2016-06-08" version="1">MSVVRTSVRYRDPSAADRLDALRAALAGVRDLPWGALSEADLLDVCAGVQDIRNVLPVVEHAAISALSECTTPAAIGAKSWPEALRIRLRISGTEARRRCRDAMNFGPRRAVSGEALAPVRAATAAAQAGGWLTPDHLDELETFFKKCPDWVAAARRAAFERKLVAVAAQETPETLRQTVAEALYLLNQDGEEPVDAAERKRGIVVHPQQPDGTSKVSGWLNAEGRAVVEPLLAKYAAPGMCNPDDESPCVTGTPSEEAIEADTRTAAQRNHDALVTIGRNALMSGDLGQHNGLPVSLIVTTTLQELEAGAGVAVTAGGSKLPVPDVIRLAAHAWHYLAVFDDATLVPLYFGRTKRIATPAQRLVLFARDRGCTRPGCTAGGYRCEAHHAEQDWTVGGQTNIDELALSCGPDNRLVAKGKWTTTMRNGRCEWTPPPLLDAGQNRINNYHHPQRYLTESDEDDEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUJ3</accession>
    <name>A0A132PUJ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)H nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844670.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20245"/>
    <dbReference type="EnsemblBacteria" id="KWX25712">
        <property type="protein sequence ID" value="KWX25712"/>
        <property type="gene ID" value="AFM11_04900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2861"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="335" mass="36448" checksum="15624584CECB8DF2" modified="2016-06-08" version="1">MPDTMIDTATIIAAVQLASRAPSLHNTQPWRWVADGAADVRSRNDLGLKLFLDPNRVVHSTDRSSREAVISCGVMLDHLRVASAASGWATSVERFPNPNNRDHLATVHFSPMQFVTDAHRRRADAILARRTDRLPMAAYADWDSFEPLLRARLADGPVHLDVLGDDVRQELAEAAALTESLRLYDSAYHAELAWWTTPFATEDGIPQSSLVSAEESERVGLSRAFPVTAHSQRRAGVNDDSATIVVLSTDGYSREDALDAGEALSTALLECTLAGLGSCPVTHVTELHASRDIIGSLINRDACPQVLIRIGIAPTLEDVPPPTPRRPVEAILTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUN6</accession>
    <name>A0A132PUN6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842836.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25984">
        <property type="protein sequence ID" value="KWX25984"/>
        <property type="gene ID" value="AFM11_01585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.325"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031702">
        <property type="entry name" value="DUF5078"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16877">
        <property type="entry name" value="DUF5078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453604" evidence="1">
        <location>
            <begin position="26"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="146" mass="16690" checksum="3131C069F94E9E1B" modified="2016-06-08" version="1">MKLEKLSLAALATAATLTLSPTAAADATEDYPIPRRILHTPCTAEQILAATRDTNPVYYERYMIDYNNKSPEVHRAVQDRIHWFFSMDYAGRRQYSENTATNAFYEQLAWNWPNWAKIFFNNKGVAAAATSVCMNYPPGDMSVWVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUN7</accession>
    <name>A0A132PUN7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_02010</name>
        <name evidence="6" type="ORF">AWC31_34790</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843037.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34790"/>
    <dbReference type="EnsemblBacteria" id="KWX26046">
        <property type="protein sequence ID" value="KWX26046"/>
        <property type="gene ID" value="AFM11_02010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11824">
        <property type="protein sequence ID" value="ORX11824"/>
        <property type="gene ID" value="AWC31_34790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.411"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="187" mass="20567" checksum="73DB8CBD2336DBD9" modified="2016-06-08" version="1">MGIHVSGGRPVLSRDTIRAVAWRVADAEGLPEVTCRRIARELGTGPASLYRHIADRRQVLNLLAEDLAAGYPLVEVAGRPEARLIAQWLAMRDYLVAHPWGAPLIADGEHTVSSAQPVADRCMSLLRELGLDDTVAQRGYRALWRLLIGHLLSRHPFGHLQGAPPEDDDFEWAMRTLLTGLVAESGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVN5</accession>
    <name>A0A132PVN5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_01060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34090"/>
    <dbReference type="EnsemblBacteria" id="KWX26227">
        <property type="protein sequence ID" value="KWX26227"/>
        <property type="gene ID" value="AFM11_01060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.217"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX26227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="31766" checksum="D5FA51ABCF6BBB94" modified="2016-06-08" version="1">MTITDARRSSRHQTLTAWPLLGPGLLIVCVLAVLPLLLVARNSVAEADRYGQVRGGFTFENFTRLADPVYAKTLVYSLAMAALNTIFCLVVGYIVAYYTVSQPAHRQPLILLLVIVPFWTDFLVRTFAWMTLLGSDGPVLGLLRMFGDAGDPLVPSQTAVMLALLYAFLPTAIFPIYASMRGIDPSLREAAADLGCGWWRTHFRVIAPLSSAGIVAAALLIFVPTLGVFVIPVLLGGGKSLLVGNLIVTLYTEFRNQPMGAALSMVVLILMIASIGIAGLILKFRNRSARWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBK3</accession>
    <name>A0A132PBK3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19711">
        <property type="protein sequence ID" value="KWX19711"/>
        <property type="gene ID" value="AFM11_34270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5196"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="68" mass="7642" checksum="578D00343EF9B47D" modified="2016-06-08" version="1">MFALYGDGHLQADDLSLSPHIDLSGHPTDPSENSVVVRDSRTWVQGGKELRNRRLVSGPQRVFTLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBT4</accession>
    <name>A0A132PBT4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diacylglycerol acyltransferase/mycolyltransferase Ag85A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34145</name>
        <name evidence="4" type="ORF">AWC31_02595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859089.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02595"/>
    <dbReference type="EnsemblBacteria" id="KWX19791">
        <property type="protein sequence ID" value="KWX19791"/>
        <property type="gene ID" value="AFM11_34145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11046">
        <property type="protein sequence ID" value="ORX11046"/>
        <property type="gene ID" value="AWC31_02595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5166"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452967" evidence="2">
        <location>
            <begin position="38"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="320" mass="33996" checksum="1D48D604C66C48DD" modified="2016-06-08" version="1">MADAHGVHRFSRGTVILTALMVAVTVGLLGPPQKAEAWSRAGLPVEMLSVPSGSMGRDIKVQFQGGGPRAVYLLDGLRAREDFNGWDIETPAFEWFYQSGLSVVMPVGGMSSFYTDWYQPAAGNGGVWTYKWETFLTSELPQWLAANKDVSTSGNAVVGLSMSGNSAMILAAYYPGQFIYAGSLSAFLNPSAGPWPGLIGLAMGDSGGFSPNAMWGPPGDPAWARNDPTVQVGRLVANNTRIWVYCGSGTPGELGGGDLPATFLEGTALQSNLNFRDQYIAAGGNNAVFNFPPTGTHTWSYWGAQLQAMKPDIQRVLGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBU4</accession>
    <name>A0A132PBU4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02580"/>
    <dbReference type="EnsemblBacteria" id="KWX19801">
        <property type="protein sequence ID" value="KWX19801"/>
        <property type="gene ID" value="AFM11_34130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5163"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="218"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="318" mass="33854" checksum="EC38E147FEBB86CE" modified="2016-06-08" version="1">MVILGYSGVQALDLVGPFDVFTSATLCLAGKENSEGGYAVTLASVDGQPVTTLTGLEFVAAPPPDPHGPIDTIVIPGGMGAEAARQNPAVIEWITTAAGHARRVVSVCTGAFLAAQAGLLDGCPATTHWASASRLANEFPTVAVDPEPIFVRSSERVWTAAGVTAGIDLALSLVEDDYGTEVAQTVARYLVLYLRRPGGQTQFAAPVWMPRAKRAPIREVQEAIESEPGGTHSISALAERAAMSPRHFTRVFTDEVGEAPGAYVERIRTDAARRQLEESDDTVTVIAARCGFGTAETMRRNFVRRLGISPDQYRKTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBY8</accession>
    <name>A0A132PBY8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35585</name>
        <name evidence="2" type="ORF">AWC31_02665</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859861.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19502">
        <property type="protein sequence ID" value="KWX19502"/>
        <property type="gene ID" value="AFM11_35585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11293">
        <property type="protein sequence ID" value="ORX11293"/>
        <property type="gene ID" value="AWC31_02665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5853"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="65" mass="6861" checksum="0F6B9627865BCE07" modified="2016-06-08" version="1">MANNDFSPSQEQVSAAFEFAGVTVPADRVAANYETYSSTLALIRKASAPGLGETVPAVGFKAHWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBZ4</accession>
    <name>A0A132PBZ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine-threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858956.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07565"/>
    <dbReference type="EnsemblBacteria" id="KWX19855">
        <property type="protein sequence ID" value="KWX19855"/>
        <property type="gene ID" value="AFM11_33820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5100"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="440" mass="46310" checksum="76BD15860F37A9EB" modified="2016-06-08" version="1">MTDRIWRLVFDEEGHSDNAAVAERVDRAEGLSDLVIFSHGWNNDEAAAKSLYDRWFRLLAKQLDPARTVGFVGVRWPSQLWRDEPIPDFEPAVAAGGGGAAALGQERVVAAGDPSLDPAELADLKNMFPSGTAELDTLARLLAAPPTMDAIPDLFEALQAFNSATPDGFSDGEADAPDAGPGMVADDQDPSELFNTFADQLLAAGVEFSDDGGGAAGLGDFAAKLWHGAKEALRQLSYWKMKNRAGVVGKDGLGPVTDRFAAKFPGLRIHLVGHSFGARVVSYALAGMTAAQPSPVKSVTLLQGAYSRFAFTEKLPFRKGSGALFGMLSRIDGPLTVCFSSHDRALGTFYPLASAAAGDDSAAAADPLFRWRAMGSHGAFNSPTQSLGADGAVYPFQTGQILNLDASGVVAKDDGPSGAHSDIFHEELSWVVAAAGGLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC75</accession>
    <name>A0A132PC75_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858493.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19933">
        <property type="protein sequence ID" value="KWX19933"/>
        <property type="gene ID" value="AFM11_33100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4952"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="27749" checksum="361333E4DFBC936A" modified="2016-06-08" version="1">MSNTPFTTPGGLNWNAAPIQLPDMPPIQAGEDAMSMTIAGILPTLAASLTTNVTALAAKENMFNGKLGDAQGAYEKADQAGQQGVGQLGQMMGQLGQMGQMASTPAQAAGQMGGQFGSLMEPLMKAMESAKGGGGPEGSGAPGSGTPGGASMGANPQQQQAEREARLNDRDAKQNEREDRQNERDIAQDKREASQDAREAQLNERSGAGSSASAPQAPAQSAPPAATAPPAGATAPPAGAAGPSESRPAPGPVPVTPHEPPRYNGGDDDLARRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC96</accession>
    <name>A0A132PC96_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858536.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17055"/>
    <dbReference type="EnsemblBacteria" id="KWX19946">
        <property type="protein sequence ID" value="KWX19946"/>
        <property type="gene ID" value="AFM11_33170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4966"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="251" mass="26842" checksum="744877FA0D7DF9D1" modified="2016-06-08" version="1">MTITTTTVEPGIVSVTVNYPPVNAIPSRGWFELADAITAAGRDLQTHVVILRAEGRGFNAGVDIKEMQSTEGFTALIDANRGCFAAFKAVYECEVPVVAAVNGFCVGGGIGLVGNADVIVASDDAKFGLPEVERGALGAATHLSRLVPQHMMRRLFFTAATVDAETLHHFGSVHEVVPRAELDEAALRVARDIAAKDTRVIRAAKEALNLIDVQKVNSSYRMEQGFTFELNLSGVSDEHRDAFAGTDKGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCK6</accession>
    <name>A0A132PCK6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858052.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19490"/>
    <dbReference type="EnsemblBacteria" id="KWX20060">
        <property type="protein sequence ID" value="KWX20060"/>
        <property type="gene ID" value="AFM11_32365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4801"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="255" mass="27289" checksum="AD1180565B701A78" modified="2016-06-08" version="1">MYGMPDEIDVRADGGLRIITLNRPDALNAVNDNLHVGLAHLWEALNEDADARAAVITGAGRAFSAGGDFNYLDELRRDEALRQKTIKHGRDLVIGMLRCRIPVIAAVNGPAVGLGCSLAALSDIVYMAETAHFADPHVQIGLVAADGGPLVWGSQISLLQAKEFALTGVRIKAERAVELGLANHVVADPLAEAIACAKKLMDLPKQAVEATKRLMNIQLEQRVMASLDYANLAEYVSFGTADFNKIVDGLIAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCN6</accession>
    <name>A0A132PCN6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_32455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858100.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20076">
        <property type="protein sequence ID" value="KWX20076"/>
        <property type="gene ID" value="AFM11_32455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4819"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="441" mass="46345" checksum="3906A31F07F01FAF" modified="2016-06-08" version="1">MTAPPNDAAESPAPVNNPRRVSIASMIGSAVESYDFFIYGTAAAAYFGSVFFHADEPIVGVLASFATLAVGFVMRPVGGYLAGHFGDRFGRKAVLFWSLVVMGIGTVLIGVLPTYDQIGVLAPILLIVLRMVQGVGFGAEWGGAVLMAVEHAPAHRRGFFGAIPQIGIPLGLVLANGAFLLSSALFDGNWVWRAPFLASAVMVAVGIYVRLGVSESPAFEKIKDANEIHRQPALEVIRSDSRMILRIIGLRLAETGGYYVATSFVLSYVGLASISSKTDVLTGTLVGSALGVASLPLFGALSDRIGRKPVFLIGSVFTIAFGIPMFLLINTGAFIMIVVAVALALLLSHDPIFAVESSWFSEQFPANVRSSGISLGYNGASVIVGFVPFVATLVYGAMGWLGPALLFVAMGIISTALAVRTRETAPAKATSETPTPQVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD52</accession>
    <name>A0A132PD52_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858719.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19892">
        <property type="protein sequence ID" value="KWX19892"/>
        <property type="gene ID" value="AFM11_33475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5028"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="164" mass="18914" checksum="D621A5E6E0A0E29F" modified="2016-06-08" version="1">MGKPSRFHAVDDANRTRNEMFSLIKEQAPRFDTTFLCKSGAYSYVRQKGEMYLYKMAWYLRFKEIALQVSTVDDGPLRDRRFSIATSKRKAQAQAAIEDVSQQLQMHRAVHICHWNAPTSWGAQVADYGLWAVHRELLGKNCQWFPPCVKPTLSSVFLPWGQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD55</accession>
    <name>A0A132PD55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857453.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25490"/>
    <dbReference type="EnsemblBacteria" id="KWX20234">
        <property type="protein sequence ID" value="KWX20234"/>
        <property type="gene ID" value="AFM11_31335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4173"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016516">
        <property type="entry name" value="UCP07580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39456">
        <property type="entry name" value="PTHR39456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10118">
        <property type="entry name" value="Metal_hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="311" mass="35305" checksum="5A744BEE61FB8B8A" modified="2016-06-08" version="1">MTDLIVRKMRFAFADHHVPFLWNETNPAFSSMANAVSFLAIAFEKMIGHMITEAMPHITNPEIAEEAQAFVRQEGQHSMAHRQHAKGLIKSYPALKETLDEVTRAFDHLTANTPLKYRLAYTADLEATFTPVFKLMLDHDDTLFAPGDDRVASLFLWHFVEEVEHRSSALIIYDAVVDDPWYRMRVAPSIFKHVWGALRIACEGFNQHVPLEERKIDALSMFGMQAKKKALMQRLPFVDVPNDGPFANAFGHLPVREMLTALSGVVRSQIPGHNPAHEKLPALADEWFARYEAGYEVTQWYTAGKKDTANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD64</accession>
    <name>A0A132PD64_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31495</name>
        <name evidence="3" type="ORF">AWC31_26075</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857532.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20260">
        <property type="protein sequence ID" value="KWX20260"/>
        <property type="gene ID" value="AFM11_31495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14647">
        <property type="protein sequence ID" value="ORX14647"/>
        <property type="gene ID" value="AWC31_26075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4204"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX14647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="98" mass="10662" checksum="FBA3DD0F0290EAC8" modified="2016-06-08" version="1">MDATEDAPPAPEKRLVIRVNSNAKMSRGKAAAHAVHAALKLYGIEYEHPVIVIGGKPDEILAQTVHIRDAGRTELEPGTLTAGASWEWRDRAEPDPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD81</accession>
    <name>A0A132PD81_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857514.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25595"/>
    <dbReference type="EnsemblBacteria" id="KWX20254">
        <property type="protein sequence ID" value="KWX20254"/>
        <property type="gene ID" value="AFM11_31440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4194"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF190" evidence="2">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DUF190" evidence="2">
        <location>
            <begin position="126"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF190" evidence="2">
        <location>
            <begin position="247"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="364" mass="38824" checksum="69004AE73DE89EDB" modified="2016-06-08" version="1">MVGHVVGRSAVSAEHLKLTAYFGERQRHGRRFAADALLDLFGEADVASSVMLRGIASFGPRHQLRSDETLSMSEDPPVAIAAVDTADKISTLADRAVEMVPRGLITVERAVLVSAGSPAAVPETAKLTIYVGRHHRVAGTPAYRAVCAVLHRHGFAGATVFLGVDGTEHGQRRRARFLSPNADVPMMIVAIGTGDQVAAVLGELAELLAEPLFTVERAQLCKSNRELLSRPKALPGQDKQGRALWQKLMIHTSETALHGGVPIHRAIVRRLLESGAAGGATVLRGVWGFSGDGKPHGDRLFQFGRQVPLTTVVVDTPDRIAATFDIVDALTADHGLVTAELVPSATTVDAGYRSGSTDLGRYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDK2</accession>
    <name>A0A132PDK2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857357.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26925"/>
    <dbReference type="EnsemblBacteria" id="KWX20416">
        <property type="protein sequence ID" value="KWX20416"/>
        <property type="gene ID" value="AFM11_31215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4148"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="336" mass="34620" checksum="17E6295396328C3F" modified="2016-06-08" version="1">MSIFAAATGVGSWPGTTARLAAEVVVGELHTLSHLVELPARGLGADLIGRAGALLVDIGIDTVPRGYRIASGRSTALRRAVSLLGEDIDALEEAWERAGLRGSGRAVKVQAPGPITLAAQLELSGGHRAITDRGALRDLAASLAEGVAMHRAEVARRLDTPVVVQFDEPSLPAALQGRLAGVTSLTPVHPVDEPVAMSLLDACVAAAGADVALHSCAAELPWKALLRSSIHAVSVDVSTLAPADLDGVGEFVDSGRTVLLGVVPGTAPERKPSWEEIAKAAVALTDRLGFSRAVLRDRIGITPACGLAGATPQWARTAIELAQKAADAFSEDPDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDR1</accession>
    <name>A0A132PDR1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30935</name>
        <name evidence="4" type="ORF">AWC31_26655</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857200.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26655"/>
    <dbReference type="EnsemblBacteria" id="KWX20367">
        <property type="protein sequence ID" value="KWX20367"/>
        <property type="gene ID" value="AFM11_30935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14746">
        <property type="protein sequence ID" value="ORX14746"/>
        <property type="gene ID" value="AWC31_26655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4089"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014555">
        <property type="entry name" value="RecF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029347">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase_AAA_core" evidence="2">
        <location>
            <begin position="176"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX14746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="392" mass="42397" checksum="9BC7CA60A750A1BA" modified="2016-06-08" version="1">MLQTIAVRGYRSLREVILPLTDLTVITGANGTGKSSIYRALRLLADCGRGQVIGSLAREGGLQSVLWAGPEQPAEEAQGTTRTRPVSLELGFAADDFGYLVDLGLPQMAGSGGRPSAFALDPEIKREVVFAGPVLRPSSTLVRRTREFAEAAAQSGRGFDELSRSLPAYRSVLAEYAHPHALPELSAVSDRLRDWRFYDGFRVDAGAPARRPHVGTRTPVLADDGSDLAAAVQTIIEAELGDLERAVAEAFDGAEISVAVTDGLFDLQLRQRGMLRPLRAAELSDGTLRFLLWAAALLSRRPPSLMVLNEPETSLHPDLVRPLATLISTAATQTQVVVVTHSRALLEFLGTTPVADEDRGTAVEIELYKQWGETKVSGLGMLTTPSWHWGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEA1</accession>
    <name>A0A132PEA1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047041150.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20653">
        <property type="protein sequence ID" value="KWX20653"/>
        <property type="gene ID" value="AFM11_28900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3660"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="360" mass="38992" checksum="FAEC009E6CC4A9A4" modified="2016-06-08" version="1">MTIVAHAHPFVIGVDTHARTHTLAVLVAATGEPVATEQFPATAAGMDRAVAWAARRTDGEMATLWVIEGVATYGAHLASVAKRAGFEVVEAARMDARAHRGAGKSDPFDARRIAAAVLSLEPEQLRRPRSDDGIRAALRVLVTAREHMTTERTATVNALTALLRVAALGIDARKPLTAGQIGEVARWRTRAEDVATSTARAEAVRMAKRVVALNEQLAANQAQIIDLIHTSKAAALLDKTGIGPVTVAVVYTAWSHAGRVRSEAAFAALAGVSPIPASSGNTIRHRLNRGGDRRLNRALHMAVITRMTHDPETRAYVERRRAEGRTTKEIRRCLKRYLARQLYRNLESLHAEPNTKPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEC6</accession>
    <name>A0A132PEC6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856510.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25035"/>
    <dbReference type="EnsemblBacteria" id="KWX20577">
        <property type="protein sequence ID" value="KWX20577"/>
        <property type="gene ID" value="AFM11_29695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3831"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="366" mass="38314" checksum="F2FFF352B926EB75" modified="2016-06-08" version="1">MTGALDGVVVVDFSRVLAGPYATMMLGDFGAEVIKVERPGVGDDTRQWGPPYDSAGVATYFNAVNRNKRSVVLDLTDPADVQRARDLVAGADIVVENFRPGTMEKLGLGYEDLRAIRPDVIYCSITGFGRDGGADLPGYDLLVQAVGGLMSVTGTEPGDPTKTGVALVDVLSGLHALSGILAALNHRNRTGEGQRVDTNLLSVLLSSMVNQASGYLGAGAVPQIMGNRHPSIAPYQTFDTADRPIAIAVGNDKQFRAFAAAIGSPELADDPRFSSNPQRVANRDALCALIETELKSNGADHWYTVLTAVGVPAGPINDLAEAFAFARELGIEAEVSVPGSPTPQVANPVTLSATPVTYRSGPPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEV2</accession>
    <name>A0A132PEV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040180.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20747">
        <property type="protein sequence ID" value="KWX20747"/>
        <property type="gene ID" value="AFM11_29210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3727"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="160" mass="16906" checksum="134FDA66A2CD8D55" modified="2016-06-08" version="1">MRWSRVLAYGMLPGLALLLAAAAGGLKWQVGSLREAQLASVESVRAATDGTITMLSYKPDTAEKDLTAAQNRLTGQFKDSYASLTHDVVIPGAKQKQISAVANVPAAASVSATANHAVVLVFVNQTVIVGTDAPTSTTSCVRVTLDKHDGRWLISQFEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEZ7</accession>
    <name>A0A132PEZ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855701.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10310"/>
    <dbReference type="EnsemblBacteria" id="KWX20893">
        <property type="protein sequence ID" value="KWX20893"/>
        <property type="gene ID" value="AFM11_27780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3429"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="461" mass="50164" checksum="41445DC70444BA8F" modified="2016-06-08" version="1">MSNGRMKVLIIGGGFGGLFCARRLGRVDVDVTLLDRAAGHLFQPLLYQCATGTLSIGHISRPLREEFARHRNVRTLLGEAVELDPGARTVTARRPDETTFTLDYDVLVIAAGMQQSYFNNAQFAAWAPGMKTLDDALSIRQRLFTAFEIAETLPPGRDRDAWLTFVVAGGGPTGVELAGQIREMATRTLANEFHSIEPEEARVLLCDGGDRVLKSFAPDLAEKATRTLQKLGVEMRMGVHVTDVRRDGVTVTPKAGGPDEVHAARTVLWTAGVEAVPFARHIAEVLGAKSDRSGRIEVDPDLSVPGHPEVFVVGDLVGRDKLPGVAENAMQGGLHVAACIRRELEGKPRRPYRYRDLGSAAYISRGNALLQVGPVRVAGFVGWLAWGFIHIAFLTGVRNRVSTVATWLATIARASRYHRAFMLGSDSMPEQRYTWSAWDAPTPPPEVQPGPGAGSPDHTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF54</accession>
    <name>A0A132PF54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855935.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10850"/>
    <dbReference type="EnsemblBacteria" id="KWX20968">
        <property type="protein sequence ID" value="KWX20968"/>
        <property type="gene ID" value="AFM11_28290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3532"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="109" mass="12473" checksum="EB7D6350B1E92D98" modified="2016-06-08" version="1">MLDADDVRRIALSFPETTEKERWNHPTFDVAGKMFVTIPDDESSFAVRCPKFERDELIAAEPHKFWVPAHEALSAWVRVRLAALEDSNELHDILLDSWRQAAPTRLTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFD8</accession>
    <name>A0A132PFD8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855320.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07010"/>
    <dbReference type="EnsemblBacteria" id="KWX21058">
        <property type="protein sequence ID" value="KWX21058"/>
        <property type="gene ID" value="AFM11_27160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3307"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="31751" checksum="26AC2A7D29DBA81B" modified="2016-06-08" version="1">MKFYIASGFLDTAEIVEIAKAADDLGYDGMGIPDHIVNLETLSTPYPYTKDGERRWQPFTHWPDPWVLVGALAQATTRLRFTTTVYIPAMRDPYAAAKAIGTAAYLAGGRVDLGVGVGWCKDEFELVGQRFDARGRRTDEMLELMRKLWSPGWAEFSGEFYTAPRLEMEPTPPHIPIWVGGLSDLALRRAARNDGWIGDLVTTDRAIAAITRLRELRAEAGLSMDGFTVLTPLVDAITSADYERAEAGGITHILTMPWMFYTGPDASLADKIDGMKRFRADLGLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFE8</accession>
    <name>A0A132PFE8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27220</name>
        <name evidence="2" type="ORF">AWC31_07150</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855352.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07150"/>
    <dbReference type="EnsemblBacteria" id="KWX21068">
        <property type="protein sequence ID" value="KWX21068"/>
        <property type="gene ID" value="AFM11_27220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09966">
        <property type="protein sequence ID" value="ORX09966"/>
        <property type="gene ID" value="AWC31_07150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3319"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX09966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="117" mass="13447" checksum="23A3B099C38F966D" modified="2016-06-08" version="1">MGLFDRFRRRGSARGAGSDPAADLRYLQQWVAEHVGVEAYVEPKTTVTDVTVVLVAADGEWTRRRAGGDAGARRLSERLQIPVYDVQKVGYPQRMRDYDARRRIERERAARQELDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFF1</accession>
    <name>A0A132PFF1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">AFM11_27175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855326.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07025"/>
    <dbReference type="EnsemblBacteria" id="KWX21060">
        <property type="protein sequence ID" value="KWX21060"/>
        <property type="gene ID" value="AFM11_27175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3310"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="143" mass="15253" checksum="B1EAC74EED13F7D5" modified="2016-06-08" version="1">MRVLVQRVRRAHVTVDGNVVGAIEPNPQGLVALVGVTHDDDAAKARRMAEKLWQLRILDGEKSASDVGAPILAISQFTLYANTDKGRRPSWNAAAPGGVAEPLVTEFTDALRKLGATVETGVFGADMQVELVNDGPVTVLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFG6</accession>
    <name>A0A132PFG6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_27130</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855306.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06980"/>
    <dbReference type="EnsemblBacteria" id="KWX21053">
        <property type="protein sequence ID" value="KWX21053"/>
        <property type="gene ID" value="AFM11_27130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3301"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="4"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="310"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX21053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="463" mass="49867" checksum="0FA4037F6A241E50" modified="2016-06-08" version="1">MQRLSGLDASFLYLETAAQPMHVCSVLELDTSTMPGGYTFDRMRDALSLRIKAMPEFREKLADSRFNLDHPVWVDDKDFDVDRHLHRIGLPAPGGRTELAEICGHIASLPLDRTRPLWEMWVIENVAGTDAHAGGRLAVMTKVHHSGVDGVTGANLMSRLCTTEPDAPPPDPVEGVGGATGLEIAINGAVKFATRPLKLVNVVPSTLSSVVDTVRRARNGMTMAAPFAAPKTAFNANITGHRNIAFAQLDLEDIKTVKNHFGVKVNDVVMALVSGVLRTFLADRGELPENSLVAMVPVSVHDRSDRPGRNQVSGMFSTLETHIDDPAERLKAISEANSVAKQHSSAIGATLLQDWTQFAAPAVFGVAMRVYAASRLSGAKPVHNLVVSNVPGPQVPLYFLGAEVKAMYPLGPIFHGSGLNITVMSLTGKLDVGIVSCPELLPDLWDLADDFAVALDELVKATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFG9</accession>
    <name>A0A132PFG9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvT</name>
        <name evidence="10" type="ORF">AFM11_27235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855361.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07170"/>
    <dbReference type="EnsemblBacteria" id="KWX21071">
        <property type="protein sequence ID" value="KWX21071"/>
        <property type="gene ID" value="AFM11_27235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3322"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="10"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="282"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="365" mass="38695" checksum="686C48FC49D98E90" modified="2016-06-08" version="1">MSDDLLHGPLEDRHRELGAGFAEFGGWLMPVSYAGTVAEHTATRNTVGLFDVSHLGKALVRGPGAAAYVNSALTNDLNRIGPGKAQYTLCCTESGGVIDDLIAYYVSDDEIFLVPNAANTAAVVAELQKHAPDGLTITDEHRSYAVLAVQGPRSAEVLASLGLPTDMDYMGYADAEFEGVFVRVCRTGYTGEHGYELLPAWDRAGVVFDALVAAVRGAGGEPAGLGARDTLRTEMGYPLHGHELSLDISPLQARCGWAIGWRKDAFWGRDALLAEKEDGPSRVLRGLKAVGRGVLRADLAVLDGDTQIGVTTSGTFSPTLKVGIALALVDTAHDIADGAHVTVDVRGRAVECEVVKPPFVEAKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFI8</accession>
    <name>A0A132PFI8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855422.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07285"/>
    <dbReference type="EnsemblBacteria" id="KWX21091">
        <property type="protein sequence ID" value="KWX21091"/>
        <property type="gene ID" value="AFM11_27350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3344"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="283" mass="29779" checksum="D1BDAB005321D3ED" modified="2016-06-08" version="1">MRRSTTSAGTDVRSRRPALAVALLAETGIAAALLVSLASPEPAQVPTPPGVPAVSTTPTADPGMRLPDGRTAALLALGGRHAGVVLDRIRAELPGAVEAVTAFWGPDWRRDIVIAVAASDEQFRVLAGGVGDIAATTTAERIMFAPGAAAMSQGALRIVLRHELFHYAARSQTAADAPRWLTEGVADYVGRPATDRRPQDAGALGQLPTDADLDSPGAARSLAYDRAWWFSRYVAETYGVPTLRALYVRACGIGHPDVATAVRDTLGADIDEVVAGWRRWLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFJ9</accession>
    <name>A0A132PFJ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06730"/>
    <dbReference type="EnsemblBacteria" id="KWX21129">
        <property type="protein sequence ID" value="KWX21129"/>
        <property type="gene ID" value="AFM11_26880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3249"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="346" mass="37567" checksum="2697080621FCF214" modified="2016-06-08" version="1">MPSQTTPASAQPVPRPGVSGTSLTLDGKPWWPIGINAYQLGTNWSVNAGCGAQVDLDDYFGRLRPHSLTRFNVYSAMAVNKHTGQLDFTALDAVFKAAERHGQLLIAVLTSDEGGCENDYFKDYAWYAGGWRTDVSHGLPMTFAAWLDTAVKRWGGSPVLAGWTAVGEPEPSDCFDHHCHWTDRACHPNSANVLRAFFDATGSRIRELDPGSLIFSGHAGGGQCGSRGDEFEMVSASPGLDVLEYHYYEETDYLPGDVYDGLQRRVEQARAVNKPLLVAEIGMEAGSCATPAQRRQVLGDAITRMRTKDAAGAMFWAFVPDPRPTECTLDIGPDDPLFAMVGTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFT8</accession>
    <name>A0A132PFT8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23280"/>
    <dbReference type="EnsemblBacteria" id="KWX21173">
        <property type="protein sequence ID" value="KWX21173"/>
        <property type="gene ID" value="AFM11_26310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3129"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="59" mass="6198" checksum="432496CA68F79622" modified="2016-06-08" version="1">MIAAMTTYQADHTLLLALPAFAPAVVVVGVVVYIAMRDRRKGDVAHSEGEDDAGQDGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG93</accession>
    <name>A0A132PG93_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_25885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854563.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36010"/>
    <dbReference type="EnsemblBacteria" id="KWX21351">
        <property type="protein sequence ID" value="KWX21351"/>
        <property type="gene ID" value="AFM11_25885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3041"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="27556" checksum="3C930E4F198B7FD5" modified="2016-06-08" version="1">MGSMCGRFAVTTDPALLAQKIQAIDETTSASGDKDVAGANYNVAPTTTISSVVKRHTEPDDESTRRVRSMRWGLIPPWVKTAEDGTPDNKGPLLINARADKVTSSPAFRNSAKNKRCLVPMDGWYEWKGQKGEKTPFYMYGADGEPLFMAGLWTTWRPAGAPKDAPPLLSCTIITTDAAGPLADIHDRMPLTISAPDWDRWLDPDSPIDEGLLRGHGDLDRIAVREVSRLVNSVRNNGPELIEPAEPEASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGK3</accession>
    <name>A0A132PGK3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_25085</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854145.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27405"/>
    <dbReference type="EnsemblBacteria" id="KWX21488">
        <property type="protein sequence ID" value="KWX21488"/>
        <property type="gene ID" value="AFM11_25085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2378"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12922">
        <property type="entry name" value="VKOR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041714">
        <property type="entry name" value="VKOR_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="12">
        <location>
            <begin position="25"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX21488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="210" mass="22489" checksum="2CC833D4E032A1BE" modified="2016-06-08" version="1">MTVTAQPAADSEHTPDDRPSGVPVARASAVWVLIAGVIGLAASLTLTVEKIEILINPAYVPSCSINPVLSCGSVMVTPQASAFGFPNPLIGIVAFTLVTVTGVLAVAGVRLPRWYWAGLAAGTLLGAAFVHWLIFQSLYRIGALCPYCMGVWAVTIPLLVVVSSIALRPLAGNAVARGIYQWRWSLVALWFTGLILLILVRFWDYWSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH60</accession>
    <name>A0A132PH60_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853743.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23700"/>
    <dbReference type="EnsemblBacteria" id="KWX21666">
        <property type="protein sequence ID" value="KWX21666"/>
        <property type="gene ID" value="AFM11_24425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2245"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="184"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="292" mass="32455" checksum="8EBA082E81199C57" modified="2016-06-08" version="1">MPDPARLVRHRDGIPVYRYWTDREAPPVSVARGRRGDLVEHGPHIHDFPVLWYVHDEGVAYVVAAGEVVDPGPMTAESAGVGVYFDPAALGHDASSPWPAWQAHPLLFPFIHGRAGGLLQLDVPVDRRALWDNMFCAIEAELAGRREAYRQATLAYLTILLIDLARLADDVVGDLRRSGEPLLAEVFTVIDRQLAQPLSLRDVADAVGMTAGHLTTLVRKRTGRTVGEWIVERRMSRARELLAGTDLPVAEVARHVGMVDAGYFSRQFRRTHGVSPREWRRTGTNGIRTETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIB8</accession>
    <name>A0A132PIB8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852347.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04295"/>
    <dbReference type="EnsemblBacteria" id="KWX22086">
        <property type="protein sequence ID" value="KWX22086"/>
        <property type="gene ID" value="AFM11_21480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1644"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="287" mass="30266" checksum="A142B7306A60EDD0" modified="2016-06-08" version="1">MTVGAELVSTTELANGFCFGEGPRWFEGLLWFSDMLGEAVHTVTLSGSMTTLPLPGHSPSGLGFRPDGTLLIVSTQRRQILRYDGDTVELLADLSDLVPAALGDMVIDDHGRAYVGSQARSGGVIVRIDPDDTVHVVAEHLDFPNGMAITPDGSTLIVAESTARRLTAFAIDADGGLTERRVFADGLDGPPDGIAVDADGGVWTALTLAHRFQRIVDGGTVTDRIDAHGRTAIACALGGPEGRMLFMVTTTDAYPERLVGTKLSRVDAAMVDVPAPGDHSSSGDHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIE6</accession>
    <name>A0A132PIE6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852431.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22129">
        <property type="protein sequence ID" value="KWX22129"/>
        <property type="gene ID" value="AFM11_21780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1704"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="75"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="215"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="342" mass="38895" checksum="806F0874A6090831" modified="2016-06-08" version="1">MAKKGRVFVRGLTSETYGLGEFRRQQLAVERVRDDSVVVDDAKVAHSGDSEKSRTWWRIGPGDEDFLTQTIQVHFVELPPQSSNHGHGHQNEAAFYILEGRGYEIHDDKRYDWAKDDLVYVHTDSVHRHFNPYDEKALALVVKAKCTWMFMGLIQQGRSGPVENEEAFGPREDWSKIWTAGVLDRKKVVGPADTVWEQTPLGRVRVIASPRHTDGRIFSIDAFELEIEAGGHSGKYWKMADEVFYVLSGGGYALQWEVEAEIAEKYYARIAREPKRYDIKQGDTLYVPQNHVCQIFAADGTPLRLFNAQNRVFKHLGYDTVHYFEPASDSDQALGELADTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIH0</accession>
    <name>A0A132PIH0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4439 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852487.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04745"/>
    <dbReference type="EnsemblBacteria" id="KWX22158">
        <property type="protein sequence ID" value="KWX22158"/>
        <property type="gene ID" value="AFM11_21940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1736"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029447">
        <property type="entry name" value="DUF4439"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14530">
        <property type="entry name" value="DUF4439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4439" evidence="1">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="155" mass="16131" checksum="ED8B9F821B60EDD5" modified="2016-06-08" version="1">MTSPESAPARPTSAADGALFDAVATEHGIIYGYGLVSAHSSPEENSLVAAAMAEHRARREAAIAMLNGRSVAAPLPAAGYQLPAEVKNPIDAANLAVRMEQDAAVAWRAVLEQATTSEDRSFAVTALTQAAVTAAKWNEFLDVWPVTVAFPGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIK3</accession>
    <name>A0A132PIK3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4'-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_22065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852531.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04870"/>
    <dbReference type="EnsemblBacteria" id="KWX22180">
        <property type="protein sequence ID" value="KWX22180"/>
        <property type="gene ID" value="AFM11_22065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1761"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009366">
        <property type="term" value="C:enterobactin synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009239">
        <property type="term" value="P:enterobactin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041354">
        <property type="entry name" value="4PPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003542">
        <property type="entry name" value="Enbac_synth_compD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38096">
        <property type="entry name" value="PTHR38096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17837">
        <property type="entry name" value="4PPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01399">
        <property type="entry name" value="ENTSNTHTASED"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4PPT_N" evidence="3">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="108"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="224" mass="24054" checksum="53FF458AF9A45DC5" modified="2016-06-08" version="1">MTGTLLAQVLPDGSDTVASAELYDDPPGLAPLPEEEPLVARSVAKRRNEFVTVRYCARQALGELGIGPVPILKGDKGEPCWPDGVVGSLTHCKGFRGAVVGRAGDVRSIGIDAEPHDVLPDGVLGAITLPVERTELSTMPGNLHWDRILFCAKEATYKAWYPLTHRWLGFEDAHITFAVDDSGTAGRFRSQILIDPAAEHGPPLTALDGRWSVRDGVTLTAIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIP1</accession>
    <name>A0A132PIP1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852286.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04130"/>
    <dbReference type="EnsemblBacteria" id="KWX22057">
        <property type="protein sequence ID" value="KWX22057"/>
        <property type="gene ID" value="AFM11_21315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1610"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="31104" checksum="0E013E7F98184D91" modified="2016-06-08" version="1">MRIGVVFPQTELDGDPGAVRAYGQRVEELGYAHILAYDHVVGADPAVHQGWAGPYNIRTTFHEPFVMFGYLAAVTTLELVTGVIILPQRQTVLVAKQAAEVDLLTGGRLRLGVGLGWNAVEYEALGEEFGNRGKRSEEQVELMRRLWTEPTVTFDGRYHRVTGAGLAPLPVQRPIPVWFGAATERALERAGRLGDGWFPMVAPGAKLDEARAHVERAALAAGRDPASIGMEGRVTWSGDAERAARELSAWVAAGASHVSVNTMGAGLDTVDAHLAALERVAAAVPLGTVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ66</accession>
    <name>A0A132PJ66_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_21225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06590"/>
    <dbReference type="EnsemblBacteria" id="KWX22343">
        <property type="protein sequence ID" value="KWX22343"/>
        <property type="gene ID" value="AFM11_21225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1591"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="509" mass="54513" checksum="4F0E24D439CADE9C" modified="2016-06-08" version="1">MVGMDLDKDSNTAPRGRLPQVERHGIDYIPEDERRSRPSNLYVLLLGGSMTFGVFIIGWYPIAFGLGWWSAATSIMAGSAVGAIFLGLSGLMGPHSGTNNPVSSGAYFGVAGRLIGSVLEGTASLAFAAISIWTGGDALASALIRFFGMPDNEVVRLVAYGVLSITVTFISVFGHHSMMASLRFILPTAGLCMIIGLFVYSRDFDASYAGTGDYAFGSQLNSWLVSALLCAATVSSYAAYSGDWTRHISPKKYSDRRIVLTLLIGGIFGMGVCFLWGAFTSAAAFNAGAADADTSFVFGVVDIVPLWYIPALLYLGLASGTTQAVINTYGTGLDTSAIFPRFNRIQATLLACGLATALVYVGHFYDRIESGMSIYLQLLVCFSIPWVVIVVYGHVLRRGYYDVDDLQVFNRRLRGGIYWYRGGLNPRMLVLWSVAAVTGMLFSVNDAYTGPLAFMIGGIDGGLIASGLVALIGCPIVHRIWPDKPDVFGPARRGPQPSVAQPPAAALEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ72</accession>
    <name>A0A132PJ72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22363">
        <property type="protein sequence ID" value="KWX22363"/>
        <property type="gene ID" value="AFM11_21010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1545"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="88" mass="9215" checksum="E9DE4C6A342C8A6E" modified="2016-06-08" version="1">MTADQATAVIGVVKAMVSAHTRGVGFTADEPNDELSAVILSASARLLANTSGVVREQMGGLEVQYGSAAFGFTLPELGVLNRYRKMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJB4</accession>
    <name>A0A132PJB4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_19950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851872.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28565"/>
    <dbReference type="EnsemblBacteria" id="KWX22430">
        <property type="protein sequence ID" value="KWX22430"/>
        <property type="gene ID" value="AFM11_19950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1324"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="350" mass="35809" checksum="0C9960D155C3A885" modified="2016-06-08" version="1">MTDGAAGVAALGIHKSYGRRRVLAGADLEVPAGTITAVLGPSGCGKTTLLRILAGFDDPDAGTVHIAGEPMIGRGPVVPAHRRRVGLMPQEGALFPHLTVGGNVAFGLAARNGVAGEVAHWLDVVGLPGLADARPHELSGGQQQRVALARALAARPRVLLLDEPFAALDAGLRTRVREDIAEILRAAGTTAVLVTHDQTEALSLADSVALLIDGAVAQHAAPADLYGRPANLATARFVGATVELAGTCRAGVAHTALGAHPVRIAVADGPAVVVLRPEQLRMRAPDGDADTAARVCASRFYGADTVVHVVLRDGTALRLRSPGDARVATDSTVTVEVVGDVLAYPSPATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJC0</accession>
    <name>A0A132PJC0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_19985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851879.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28530"/>
    <dbReference type="EnsemblBacteria" id="KWX22436">
        <property type="protein sequence ID" value="KWX22436"/>
        <property type="gene ID" value="AFM11_19985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1331"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="578"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="767" mass="80669" checksum="99B06CF289C3F13A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJC6</accession>
    <name>A0A132PJC6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_19955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851873.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28560"/>
    <dbReference type="EnsemblBacteria" id="KWX22431">
        <property type="protein sequence ID" value="KWX22431"/>
        <property type="gene ID" value="AFM11_19955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1325"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="55"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="308"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="511" mass="53419" checksum="48CF0DAE82850F0A" modified="2016-06-08" version="1">MSGRGRRAPAPLVGAAALVVLATLVPLVYLGERAVERGWAFVVDELWQQRTAALVGRSLTLVVVVTAICVVLGVGLAVLVSRTDLRGRRGLAVALTLPLAMPSYLLAYLWVSVYPAVEGFWGACLVLVLVSYPLVFLTTVAALSRVDPALEEVARSLGHGGLSVLFRVTLRQARGAITAGALLVALYVLSDFGAVAAMRYEVFTWVIYGAYRSGFNPSRAAVLSLVLLVLALVLVLAEARARGIAAARIGGGTPRPAPLNRLRRWWPVALLVPMAVLAAAIGVPTLALVHWLLTAGARWDGGEWVAALAATVWLSVIAAVVCTVAALPLGVLAARYRDRATRVLEGASYVAHGLPAIVIGISMVSLGVVLLRPLYQHAPLLILAYAVLLVPLAVGSVRAAVETTPVRLEEVAQSLGRSPLRAFGAVTARLSVPGIGAGAALILLTCMKELPVTLLLHPTGVDTLATRLWGYSSVSDYAAAAPYAAALVVFAAVPTAALGFFSAGRSGVRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJE7</accession>
    <name>A0A132PJE7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851897.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28435"/>
    <dbReference type="EnsemblBacteria" id="KWX22455">
        <property type="protein sequence ID" value="KWX22455"/>
        <property type="gene ID" value="AFM11_20080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1352"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="146" mass="16052" checksum="470DDB47AEB56BBB" modified="2016-06-08" version="1">MTTRYDAPGPVARAGNDLIRHLAELGISIAGTTALRVRGRRTGKPHAVVVNLLSVDGEKFLVSPRGNTQWARNARAAGAVDIGPRWRRRTVPIAEVPDDGKPPLLKRYLDRWYWEVKGHAAGLTPQSTDAELRDGARSIPVFKLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJY2</accession>
    <name>A0A132PJY2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19380</name>
        <name evidence="6" type="ORF">AWC31_15465</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851713.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15465"/>
    <dbReference type="EnsemblBacteria" id="KWX22659">
        <property type="protein sequence ID" value="KWX22659"/>
        <property type="gene ID" value="AFM11_19380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17822">
        <property type="protein sequence ID" value="ORX17822"/>
        <property type="gene ID" value="AWC31_15465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1209"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX17822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="221" mass="24775" checksum="AED2D091888CC34D" modified="2016-06-08" version="1">MAVSSSNGSIQGRLIEEIRRRIIAGEISPGVNISELAIAEEFGVSRTPVRETFKQLQTEGLIEIRPRVGTFVTTPSRREITELFQMKELLEGAAARLLAQRGRVPEIDKLEENLRQADHAVANDDRARYAELVEEFHDLLIVGADNNKLEAHYRMLMNQLAYARLVHTSLSQPGRPLQSDREHHVVLDLIIAKDGDSAERVMREHVRASRQALLAGLGDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK51</accession>
    <name>A0A132PK51_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactofuranosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851487.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22420"/>
    <dbReference type="EnsemblBacteria" id="KWX22711">
        <property type="protein sequence ID" value="KWX22711"/>
        <property type="gene ID" value="AFM11_18675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1072"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="307" mass="34476" checksum="3FF1E5EFBC66A947" modified="2016-06-08" version="1">MCVRCSRKPRVADLVCAVVVTHRRRELLAKSLDAVVAQDRAPDHLIVVDNDNDPAVRDLVTGQPIPSTYLGSRRNLGGAGGFALGMLHALTLGADWIWLADDDGRPADATVLGTLLACAEQHSLAEVSPMVCNLDDPERLAFPLRRGLVWRRLVSELRTEGSGDLLPGIASLFNGALFRAATVDAVGVPDLRLFVRGDEVELHRRLVRSGLPFGTCLTASYLHPCGTDEFKPILGGRMHTQYPDDETKRFFTYRNRGYLLSQPGLRKLLPQEWVRFGWYFLVSRRDPAGLREWIRLRRLGRRERFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK76</accession>
    <name>A0A132PK76_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 4">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_17475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 4"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851052.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04995"/>
    <dbReference type="EnsemblBacteria" id="KWX22749">
        <property type="protein sequence ID" value="KWX22749"/>
        <property type="gene ID" value="AFM11_17475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.850"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="5">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="158" mass="17535" checksum="0118A94226418FFF" modified="2016-06-08" version="1">MTVGLIWAQSGTGIIGRDNGIPWRLPEDQARFKELTLGHTVVMGRLTWESLPAKVRPLPGRRNVVVTRDAAYRADGAEVVTGLPDDLDGWVIGGAQIYAMALPIADRCEVTEIDIDLPRDDHDALAPVLDETWVGTTGEWQTSSSGLRYRFCTYRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKD4</accession>
    <name>A0A132PKD4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851084.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05100"/>
    <dbReference type="EnsemblBacteria" id="KWX22763">
        <property type="protein sequence ID" value="KWX22763"/>
        <property type="gene ID" value="AFM11_17580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.871"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="110" mass="11803" checksum="DEE7EE896D1B0217" modified="2016-06-08" version="1">MTALLREVIGDVLRNARTDQGRTLREVSDAARVSLGYLSEVERGRKEASSELLSAICDALDVPLSRVLTDAGEGMARRERDAAQLAQTNVAHIDVSTKVVIPQAVSMAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKR2</accession>
    <name>A0A132PKR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18185</name>
        <name evidence="3" type="ORF">AWC31_12255</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851447.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12255"/>
    <dbReference type="EnsemblBacteria" id="KWX22931">
        <property type="protein sequence ID" value="KWX22931"/>
        <property type="gene ID" value="AFM11_18185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18890">
        <property type="protein sequence ID" value="ORX18890"/>
        <property type="gene ID" value="AWC31_12255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.994"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="177" mass="18769" checksum="EBFAA1AAAB8E897A" modified="2016-06-08" version="1">MCEVTVEVPAPADLPELAAVAAATFPLACPPSATPDNIAAFIAENLSAQRFAGYLSDPERIVLVSRDGDAITGYAMLIHGVPADDDVQGAVTERPALELSKIYVLADHHRGGAAAALMAETLKRAADAGMSCVWLGVNQQNVRAQRFYAKHGFNIKGTKTFQLGAGVENDYVMVRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKW0</accession>
    <name>A0A132PKW0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851451.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12285"/>
    <dbReference type="EnsemblBacteria" id="KWX22933">
        <property type="protein sequence ID" value="KWX22933"/>
        <property type="gene ID" value="AFM11_18215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1000"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="386" mass="39446" checksum="421EE504197E9735" modified="2016-06-08" version="1">MAAGGALLVVAVVLTALNLRPAITSVGPVLGEMRESLGASAVWAGALTTLPGLCFAAAGLAAPWLAHRIGLGRAISVAMAVLSIGLLVRVLDGPYVVIGGTLVATAGIALVNVLIPVVIKGSFPARIGLMTGIYTAALQGGGALGSAATPPLESVFHSWRGALGSWATLAVLALVFWLLGSRGITTARTADSSSGGSTRSLMRSSLAWTVTLFFGCQAFLAYVVMGWLPEVFIDNGVSKSDAGLLVGLASVLAVPISLFIAPLAARQSNQSWWIVGLGVVGFAGMIGLLVDPGAAPLLWSVLVGLGMSVFSLALTVIALRARNAEDTARLSGMVQGFGYLLAGIGPFLFGLLHEATGGWTVPWAMVLVVYLVQMVAGALAGRNRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL08</accession>
    <name>A0A132PL08_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme oxygenase (biliverdin-producing)</fullName>
            <ecNumber evidence="2">1.14.14.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_18250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heme oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.18" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851309.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12320"/>
    <dbReference type="EnsemblBacteria" id="KWX22867">
        <property type="protein sequence ID" value="KWX22867"/>
        <property type="gene ID" value="AFM11_18250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1007"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018207">
        <property type="entry name" value="Haem_oxygenase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00593">
        <property type="entry name" value="HEME_OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="217" mass="24002" checksum="926DAEA27A85B49A" modified="2016-06-08" version="1">MPSAVVPEAIRSLSAAMRENSQAEHDAAEQSSFMSELLSGRVNEQGYVDYLVRLRAIYAALEDAVRAHHADPLVAAVYDPALERLGPIDADLDHWAPDAPRVVDSPATREYCDRIAESSWAGSLIAHHYTRYLGDLSGGQAIGRILDRTFGLNGAGLSFYAFPMRPKPYKDDYRARLDGLALSTDEAEAVVNEVKVAFRLNHALFDELAHNLSTYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL18</accession>
    <name>A0A132PL18_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_18455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851331.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12410"/>
    <dbReference type="EnsemblBacteria" id="KWX22877">
        <property type="protein sequence ID" value="KWX22877"/>
        <property type="gene ID" value="AFM11_18455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1025"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="234" mass="24410" checksum="0B4ED0903FBDC7EE" modified="2016-06-08" version="1">MSDTDESAPIDRRRHILRLAAFAAFLLGLFYLVAVARVVDVDDVRATVAATGPVAPLTYVFVSAVLGALFVPGPILAAGSGVLFGPVLGTFVTLGATVGTAVIASLIGRRAGRDSARALLGAARADRLDRQIERGGLWAVVGQRFVPGISDALASYTFGAFGVPLWQMAVGAFIGSVPRAFVYTALGASIGDLSAPLAYTAIGVWCVTAIIGAFAAHRGYRSWRNRDHTPEPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLA2</accession>
    <name>A0A132PLA2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_16835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850773.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01405"/>
    <dbReference type="EnsemblBacteria" id="KWX23034">
        <property type="protein sequence ID" value="KWX23034"/>
        <property type="gene ID" value="AFM11_16835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.720"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="50"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="319" mass="35510" checksum="8F9CA2F86C5E9A29" modified="2016-06-08" version="1">MGVFDRVARPAILAASRSQRLRRTAERLPVTRKVVDRFVAGETIPDALDAVAVLRGSGRLVTIDYLGEDTTSSEDAEHTVRAYLALLDGLQRRPETVTPVRPLEVSLKLSALGQALPRDGEKIALENAHTICAKARDVGAWVTVDAEDHSTTDSTLAIVRDLRTEFDWLGTVLQAYLKRTQADCEEFAAAGARIRLCKGAYDEPASVAYRDADEVTDSYLRCLKTLMGGRGYPMVASHDPVIIDAVPGLAREFGRGVDDFEYQMLYNIRDAEQRRLADAGNHVRVYVPFGYEWYGYFVRRLAERPANLTFFLRALAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLI5</accession>
    <name>A0A132PLI5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23206">
        <property type="protein sequence ID" value="KWX23206"/>
        <property type="gene ID" value="AFM11_15380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7191"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="377" mass="41295" checksum="387EC0BCE28E5885" modified="2016-06-08" version="1">MGAYRGLTWDHPRGVDALRRAVREDTAPRCEIVWDTQSLEGFESAPICDNAARYDLLVLDHPHLGEALRCGALLPLEEVFNSAELDDWKRGTVGDSFASYQMDDRSWALPLDAATQVSVAADPAIDIPTTWTDAVELARDVDTVLPTSGPHLFLTLCSIALANGEEPGRHDEFLTAEAIAEGLDTITAFIDHRLPPPRSHNPIVVLEQMSQPGGPVYCPLVYGYVNYAQAGLPRPLLFADAPKGRSGRRGSVLGGTGIAISSRCRPGDDLVRHLRWLLDDATQSTFIPEHAGQPSALAAWRNPLVDKASSGFYSRTADTIGQAWIRPRFDGAISFQRRAAECVREAVLSHRNADRLAAELTRLHLASLDRQHRVGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLM8</accession>
    <name>A0A132PLM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_17655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851414.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05175"/>
    <dbReference type="EnsemblBacteria" id="KWX22912">
        <property type="protein sequence ID" value="KWX22912"/>
        <property type="gene ID" value="AFM11_17655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.886"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="26332" checksum="0C107F3F32DF6060" modified="2016-06-08" version="1">MISLQGVNKHFGSLHVLKDINLDVGRGQVVVVLGPSGSGKSTLCRTINRLETIDSGTISVDGEQLPAEGRKLAQLRSDVGMVFQSFNLFAHKTILENVTLAPMKVRKATKEKARDNAMALLERVGVANQADKYPAQLSGGQQQRVAIARSLAMNPKVMLFDEPTSALDPEMINEVLAVMTSLAGEGMTMVVVTHEMGFARRASDRVVFMSDGAIVEDSEPAEFFDNPKTDRAKDFLGKILHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLX3</accession>
    <name>A0A132PLX3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850169.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15890"/>
    <dbReference type="EnsemblBacteria" id="KWX23187">
        <property type="protein sequence ID" value="KWX23187"/>
        <property type="gene ID" value="AFM11_15270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7167"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01051">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039377">
        <property type="entry name" value="Mn_catalase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="297" mass="33137" checksum="FAD4D8B808B3AEF5" modified="2016-06-08" version="1">MFIHNKDLQFEVRVTEPDPRFATLLQEQFGGANGELKAAMQYFTQAFVLREKNPKMYDLFMDIATEELSHLEMVGSMITMLLDGLNDDLKMANERCDWMPAVGSADGRDQIMHSVAVNPLYFVLTGGGPDVSNSQGVPWQGSYVNANGDPSVDLRSNLAAESRAKVVYEYLKQFTDDPGVQDTLTFLMTREVAHYQQFTAALNELPVNFPPGQLPGDDRFQNVAFNMSNGAGDARGPWNQGQGPWPEGMKWKYVNKPEEEWLGGRLRQNQGAKKNPEGAPAVDSEKPFTHEQHTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLZ0</accession>
    <name>A0A132PLZ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein lpqE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850432.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16585"/>
    <dbReference type="EnsemblBacteria" id="KWX23313">
        <property type="protein sequence ID" value="KWX23313"/>
        <property type="gene ID" value="AFM11_16010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7327"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453125" evidence="2">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="194" mass="19814" checksum="9D5430B59D4C75BA" modified="2016-06-08" version="1">MNRLTFRASAGLAACGLAAAVALTACGAGQVSQTATQEPAVNGVNAQAGQVSLRNVHLRAPQEGDYVEPGSAVELLFVAVNDSPEADNKLVSITSDVGQVTLSGDSTVPASGVLLVGEPDGQLAPVEEAESADAVTAEVSLTKPITNGLLYDFTFNFENGKTTVAVPISAGNEPRRDQTGETQEAEGGEARGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PME3</accession>
    <name>A0A132PME3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849895.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23508">
        <property type="protein sequence ID" value="KWX23508"/>
        <property type="gene ID" value="AFM11_14660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7041"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="107" mass="11716" checksum="8102D904AE4E4DF0" modified="2016-06-08" version="1">MAEVPTATSRNGGIAVSTTERGLPVALRIDPRELQKSPELLAAEILALCRLSAVRAQVARRRELLSQNVSPAVIRNLKLANEEDLRMAEDRAAEGDDVLPNSWMRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMW9</accession>
    <name>A0A132PMW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12910</name>
        <name evidence="6" type="ORF">AWC31_03195</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849129.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03195"/>
    <dbReference type="EnsemblBacteria" id="KWX23686">
        <property type="protein sequence ID" value="KWX23686"/>
        <property type="gene ID" value="AFM11_12910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11145">
        <property type="protein sequence ID" value="ORX11145"/>
        <property type="gene ID" value="AWC31_03195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6674"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="189"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="381" mass="41396" checksum="9C8245900F87891B" modified="2016-06-08" version="1">MSGNDFANSNEAIEPLRIVLVAPPYFDVPPKGYGGTEAVVADLADALVKRGHRVTLLGAGEPGTAASFKPLWRQTMADRLGQPYPEIMHALKVRRAIEHIASTDGVDLIHDHTFAGPLNTPAYRNLGLPTLVTVHGPIDDDLYPYYRELGDDVGLIAISDRQRELAPDLNWVGRVHNALRIDDWPFRSDKGDYALFLGRYAPYKGAHLALQAAHEAGMPLVLAGKCSEPSEQAYFDEQVRPLLTENDHVFGQADAVSKRKLLAGARCLLFPIQWEEPFGMVMIEAMACGTPVVALRGGAVPEVVVDGVTGVLCDRPEELATAIDKAQALDPAACRRHVAAHFAVGQFGSGYERIYRSVLGAPQPITLRQIVEPGMPERASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN08</accession>
    <name>A0A132PN08_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13110</name>
        <name evidence="3" type="ORF">AWC31_03395</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849232.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03395"/>
    <dbReference type="EnsemblBacteria" id="KWX23721">
        <property type="protein sequence ID" value="KWX23721"/>
        <property type="gene ID" value="AFM11_13110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11180">
        <property type="protein sequence ID" value="ORX11180"/>
        <property type="gene ID" value="AWC31_03395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6715"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019662">
        <property type="entry name" value="DUF2516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10724">
        <property type="entry name" value="DUF2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="94" mass="9856" checksum="92A5D4042C2E34FB" modified="2016-06-08" version="1">MILANLAGVIVAVLVVLVLIVGVYAFVHAAMQRPDAYTATGKLTKPVWLAIIGVGLLLALLLRDAFGAAISACATGVYLVDVRPKLLEIQGKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN56</accession>
    <name>A0A132PN56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13415</name>
        <name evidence="6" type="ORF">AWC31_03700</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849371.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03700"/>
    <dbReference type="EnsemblBacteria" id="KWX23769">
        <property type="protein sequence ID" value="KWX23769"/>
        <property type="gene ID" value="AFM11_13415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11230">
        <property type="protein sequence ID" value="ORX11230"/>
        <property type="gene ID" value="AWC31_03700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6777"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="215" mass="23774" checksum="C1689E004F74BF66" modified="2016-06-08" version="1">MSAKILLADDHALVRAGLRMIIDAEPDLHVVAEAADGYEALSALDRTPADLAILDIAMPRMTGLQAAREINRSHPHVRILILSMYDNEQYFFEALKAGASGYVLKSVADRDLLEACRATLRGEPFLYAGAITALIRDYLHRARQGGEMPDNILTPREEEVLKLIAEGYSTREIAATLTISAKTVDRHRTNILSKLGLRDRLALTRYAIRAGLIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN57</accession>
    <name>A0A132PN57_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_14480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849837.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18345"/>
    <dbReference type="EnsemblBacteria" id="KWX23482">
        <property type="protein sequence ID" value="KWX23482"/>
        <property type="gene ID" value="AFM11_14480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7004"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="13"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="418" mass="44328" checksum="6A8A0711E84E23C3" modified="2016-06-08" version="1">MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDSRLGRRVAVKVLKAEFSTDAEFVERFRAEARTVAMLNHPGIASVYDYGETELDGEGRTAYLVMELINGEPLNSVLKRTGRLSLRHALDMLEQTGRALQVAHTAGLVHRDVKPGNILITPTGQVKLTDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDATAASDVYSLGVVGYESVSGKRPFTGDGALTVAMKHIKETPPPLPADLPPNVRELIEITLVKNPGMRYKSGGPFADAVAAVRSGRRPPRPNQAPTLGRAAPAAVPSAAQARAAADLTGRAPVTAARARPTATSAHRPAPPPRRTFSSGQRALLWAAGVLGALAIVIAILIVLNAQDRKEREQTPPPTVTDTVTETTPYQSPAALPELGLHVIMPRAPAAPEQILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PND1</accession>
    <name>A0A132PND1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ppx-GppA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849188.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03310"/>
    <dbReference type="EnsemblBacteria" id="KWX23707">
        <property type="protein sequence ID" value="KWX23707"/>
        <property type="gene ID" value="AFM11_13025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6698"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="17"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="323" mass="34116" checksum="5B65F4981BE419CE" modified="2016-06-08" version="1">MRLGVLDVGSNTVHLLVVDARRGGHPTPMSSTKAALRLAEAIDNSGKLTRKGADKLVETVDEFAKIATSSGCAELMAFATSAVRDATNSEDVLARVRSETGVSLQVLSGVDESRLTFLAVRRWYGWSAGRIINIDIGGGSLELSNGVDEEPEVALSLPLGAGRLTREWLPDDPPGRRRVAMLRDWLSTELADAGAKMLKPGPPDLAVATSKTFRSLARLTGAAPSGAGPRVKRTLTATGLRQLIAFISRMTAADRAELEGVSAERAPQIVAGALVAEASMRALEVESVDICPWALREGLILRKLDSEADGTALVGTAARDAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNG0</accession>
    <name>A0A132PNG0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849458.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03880"/>
    <dbReference type="EnsemblBacteria" id="KWX23804">
        <property type="protein sequence ID" value="KWX23804"/>
        <property type="gene ID" value="AFM11_13635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6823"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="74" mass="8085" checksum="DD287C5BA4DA3603" modified="2016-06-08" version="1">MLARLRRLLAYRIAVGELLVAGTILGAPYLLIGAIWSSTHTDHLEQMAPLDATVSFLGSIVSWPVLLFTDICMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNR5</accession>
    <name>A0A132PNR5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848028.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31200"/>
    <dbReference type="EnsemblBacteria" id="KWX23914">
        <property type="protein sequence ID" value="KWX23914"/>
        <property type="gene ID" value="AFM11_11055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6287"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="164" mass="18039" checksum="65491F3BB83BB87F" modified="2016-06-08" version="1">MIRTQVVLRVNDRDHEVWVRNDRTLLDVLHDDLGMPDVRYGCAEGVCGTCTVLMDGDPVSACCVYAVQAEGHDIVTLRGWSDPQDEPHPLQKCFLERGASQCGFCTPGMLLTAATLAERNPDASREEIRHELVGNLCRCTGYQAIVDAVEDYLHAPAVERGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNY3</accession>
    <name>A0A132PNY3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849322.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03595"/>
    <dbReference type="EnsemblBacteria" id="KWX23752">
        <property type="protein sequence ID" value="KWX23752"/>
        <property type="gene ID" value="AFM11_13310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6755"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="125" mass="13578" checksum="8AB656BC3D3490DC" modified="2016-06-08" version="1">MSVKVDLNQLAAKLTDYTFAYLVTVDDNYHAHTVAVEPQLVDGVIDVGPVGGHTRRNLASHDGVTLIWPPRWPGGFSLIVDGRGQPAATDDDTQQIVPSRAVLHRKRSRHSANPGTNDCVVLSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP47</accession>
    <name>A0A132PP47_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ornithine--oxo-acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11975</name>
        <name evidence="4" type="ORF">AWC31_10000</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848532.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10000"/>
    <dbReference type="EnsemblBacteria" id="KWX24073">
        <property type="protein sequence ID" value="KWX24073"/>
        <property type="gene ID" value="AFM11_11975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09262">
        <property type="protein sequence ID" value="ORX09262"/>
        <property type="gene ID" value="AWC31_10000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6474"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="426" mass="46667" checksum="B706950055A8D88B" modified="2016-06-08" version="1">MYDYGTFAFASKAEVLEQAKTFWNPDKTQFWTDSGVDLVIDRREGYFLWDMSGRRLIDMHLNGGTYNLGHRNPEVMQAISEGMSHFDVGNHHFPSVARTALAQRLVATAPASISKVAFGSGGGEAIDIALKSARHATKRRKIVSIIKAYHGHTGLAVATGDDRFAKMFLADLPEEFIQVPFGDVAAMEQALAGNDVAAVIMETIPATYGFPLPPPGYLEAVKAATEKHGTLYIADEVQTGLMRTGELWGITKHGIDPDILVTGKGLSGGMYPITAALLSERAAQWLDEDGFGHISTFGGAELGCVAAIKTLEICTRPEVRSMVHYIADLFDQGLRRIQDDHPDWFVGVRQNGVVIGLEFDHPEGAKFVMRELYENGVWAIFSTLDPRVLQFKPGLLLSRELCEDVLDRLEVAVSRAKTAAKGRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP62</accession>
    <name>A0A132PP62_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848696.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09685"/>
    <dbReference type="EnsemblBacteria" id="KWX24129">
        <property type="protein sequence ID" value="KWX24129"/>
        <property type="gene ID" value="AFM11_12295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6538"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="189" mass="21337" checksum="751EEC4DAD8B3D43" modified="2016-06-08" version="1">MAESGGDWAPYQQLQEAAAVYLRDPQMAMEALRGVVDLDAIQGFTMDRFTKQRDGREVLYQEIAITDGRRLVLWMGDDLFADDDGDGFDDDDDDEPAAALFESAIRVIPLSWIYDVSLDANYRVEGQRRALHSVELRIYVGSTDYTKARTPEKTEFHSEDFVFSKSHSDGGVAQAQRLMQFGKLMATHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP68</accession>
    <name>A0A132PP68_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848703.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09675"/>
    <dbReference type="EnsemblBacteria" id="KWX24131">
        <property type="protein sequence ID" value="KWX24131"/>
        <property type="gene ID" value="AFM11_12305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6540"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023921">
        <property type="entry name" value="ADH_Zn_actinomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03989">
        <property type="entry name" value="Rxyl_3153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="10"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="374" mass="39587" checksum="7530551EB3C107FD" modified="2016-06-08" version="1">MKTKGALLWELNSPFKVDEIDLGDPVADEVQIRMHAAGMCHSDYHITTGATPIGLPALGGHEGAGVVTKVGKNVTGIEEGDHVILAFIPACGVCPPCLKGFRSLCDRGAVLLGGKAIADGTSRIHAGSHEVSPMNLLGTFAPYMTVHKDSVVKIDKDVPFETAAIMGCAVPTGFGSATNVADVKPGETVIIVGVGGIGMSALQGAVISGAKHVIAIDPNEWKREQALKFGATHVYPSMAEAIAPIIDVTYGLMGDKVIIAVGEMKGEYIEEALILTAKTGTCVVTGMGSMMDADVKLNLFLFTMLQKTLKGNIFGGGSSHVETPRLVALYKSGLLNIDDMITRTYKLEDINQGYQDMLDGNNIRGVIRFDESDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPK2</accession>
    <name>A0A132PPK2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CP_ATPgrasp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847074.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05830"/>
    <dbReference type="EnsemblBacteria" id="KWX24204">
        <property type="protein sequence ID" value="KWX24204"/>
        <property type="gene ID" value="AFM11_09395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5916"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007302">
        <property type="entry name" value="CP_ATPgrasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016450">
        <property type="entry name" value="UCP005522"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04174">
        <property type="entry name" value="CP_ATPgrasp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005522">
        <property type="entry name" value="UCP005522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP_ATPgrasp_1" evidence="2">
        <location>
            <begin position="109"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="549" mass="60201" checksum="E0C553167E0F784B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPN2</accession>
    <name>A0A132PPN2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="6" type="ORF">AFM11_09555</name>
        <name evidence="7" type="ORF">AWC31_05670</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847179.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05670"/>
    <dbReference type="EnsemblBacteria" id="KWX24234">
        <property type="protein sequence ID" value="KWX24234"/>
        <property type="gene ID" value="AFM11_09555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09714">
        <property type="protein sequence ID" value="ORX09714"/>
        <property type="gene ID" value="AWC31_05670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5948"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX09714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="103" mass="11062" checksum="1D37BF7656E0B23B" modified="2016-06-08" version="1">MATYAIVKTGGKQYKVAVGDVVKVEKLDSEPGASVSLPVALVVDGAKVTSKADDLAKVAVTGEVLEHTKGPKIRIHKFKNKTGYHKRQGHRQQLTVLKVTGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPP9</accession>
    <name>A0A132PPP9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidinol phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11650</name>
        <name evidence="6" type="ORF">AWC31_30375</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848349.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30375"/>
    <dbReference type="EnsemblBacteria" id="KWX24012">
        <property type="protein sequence ID" value="KWX24012"/>
        <property type="gene ID" value="AFM11_11650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12309">
        <property type="protein sequence ID" value="ORX12309"/>
        <property type="gene ID" value="AWC31_30375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6407"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX12309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="264" mass="27956" checksum="F60685100A753D42" modified="2016-06-08" version="1">MSVEQQAGPIVADAVSWSAGGRLVIGGVSLVLREGETLGLLGPNGSGKSSLLRLLAGLRRPSGGAVLLDGRSLAGHRRRTVAQRIAVVEQQVSTDINLTVEQIVRLGRIPHRGVWSGDAAADDAAVERALAHTGTVHMRNRDWRTLSGGEQQRVQIARALAQEPRELLLDEPTNHLDIRHQFELLALIRDLPVTAVVTLHDLTLAALFCDRLVVLAEGRVAAAGVPAEVLTPALISAVYGVDARVIADGAGAGRPSVHLLPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPW5</accession>
    <name>A0A132PPW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_10490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847646.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18925"/>
    <dbReference type="EnsemblBacteria" id="KWX24386">
        <property type="protein sequence ID" value="KWX24386"/>
        <property type="gene ID" value="AFM11_10490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6138"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="22603" checksum="ABA9E092953C58B8" modified="2016-06-08" version="1">MASARRIGAPDAKNRIVLLDAAEKLMIEEGYAAVTSRRVAEHAGLKPQLVHYYFRTMDDLFLAVFRRRAEEGLVEQARALDSAQPLWALWRFGTDPGATRLTMEIMGLANHRKALRAEIAHYAEKFREEQTKAMTAALRRYGVDSSDVPPIVWTIFATSVSRVMVMEQALGMSAGHAEVLEFCESWLRRLEGEPQPIEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPX1</accession>
    <name>A0A132PPX1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24388">
        <property type="protein sequence ID" value="KWX24388"/>
        <property type="gene ID" value="AFM11_10500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6140"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="128" mass="14135" checksum="6EA6AD7905DFC1CF" modified="2016-06-08" version="1">MPFGNYDLHIPDRRDFHTWVLSAIAPCRGENNSKRHDCLNVGLIPRPIAKAVQPTGEANLVDGRYTFVVNDPFGLRCGDIYYGPTIPTHDVYSWDANTLAGEMVSAFDVGCDNAPGGSFTYPITLTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ69</accession>
    <name>A0A132PQ69_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltranspeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847923.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05425"/>
    <dbReference type="EnsemblBacteria" id="KWX24480">
        <property type="protein sequence ID" value="KWX24480"/>
        <property type="gene ID" value="AFM11_09800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5998"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="527" mass="55269" checksum="3B6AD70C3BF14237" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ70</accession>
    <name>A0A132PQ70_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847922.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05505"/>
    <dbReference type="EnsemblBacteria" id="KWX24479">
        <property type="protein sequence ID" value="KWX24479"/>
        <property type="gene ID" value="AFM11_09720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5982"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="247" mass="27431" checksum="28FDBEDBC7365E50" modified="2016-06-08" version="1">MALLDDIMNAAGGLDRWRAGQQVLGTLESSGSLFEIKQMPGRSKRKFAVAMREVWAAVWPAGDTSHVEFTADGTALVAEDGTELARRHNVRDTFAGHILESPWNPLQRAYFSGYALWNYLNLPFLLTLPGVHTYAIEPIGTGDRRLVGLGATLPAGLPSHCRRQQFYFGPDLLLARHGYHLDIAGRIPVIQYVEDHVDVDGLKIPTTRRAYLRDDRSQPRSQLPLVSLGFTDLRVTSRDSATAVRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQC1</accession>
    <name>A0A132PQC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845996.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22040"/>
    <dbReference type="EnsemblBacteria" id="KWX24531">
        <property type="protein sequence ID" value="KWX24531"/>
        <property type="gene ID" value="AFM11_07540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5356"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="306" mass="31359" checksum="363866C6031AC56F" modified="2016-06-08" version="1">MTTLRFDDRVAVITGGGRGLGRAYALLLASRGAKVVVNDSGGSLTGDGADAAPAHDVAAEIAAAGGVAVASTDSVVTPDGGRAIIDTAIEHFGRLDILIHNAGTVRRGSLKEMSFADFEAVLDVHLRGAFHVVRPAFPIMCDAGYGRVVLTSSIGGLYGNHNVANYAVAKAGLIGLSNVVALEGAAEGVTCNVIVPSAVTRMAEGIDTSAYPPMGPELVAPTVGWLAHESCSVSGEMLIAIGGRVARALIAETSGVYRPSWTIEDVAENLGAIRALENSVIFPVVPDGHADHIRYSFAMASQGVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQZ9</accession>
    <name>A0A132PQZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Growth inhibitor PemK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847057.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05870"/>
    <dbReference type="EnsemblBacteria" id="KWX24472">
        <property type="protein sequence ID" value="KWX24472"/>
        <property type="gene ID" value="AFM11_09355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5908"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="200" mass="22628" checksum="86BB6BEE5D2B1635" modified="2016-06-08" version="1">MASQWKTFQKFAENLVFNEAPKLVRQLQRPENVPRTVQQGIQQGIKLGLEVLAGGPGDKAPAITAGRPVSKHSVPTAHRARKLVYSPDLDGRADPGEIVWTWVVYEDDPTKGKDRPVLVVGRDQRTLLGLMLSSQDYHRDDPDWVGIGTGTWDYDGRQSWVRLDRVLDVPEEGIRREGAILDRDRFEVVAARLRTEYSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRC3</accession>
    <name>A0A132PRC3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24814">
        <property type="protein sequence ID" value="KWX24814"/>
        <property type="gene ID" value="AFM11_09190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5687"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="346" mass="38728" checksum="C9B0BEF5188714F9" modified="2016-06-08" version="1">MPSYRQEFVRAIAESGEDVLFLVGDRQFGDGVVTDVDSPIVRKTGRNIYLMGRKLVWQPGCLMLGFLARNLVIELNPRNLTSWLLLISRLLTFRQASAWGHAHSRRGSKPEFNRPRRFMQGLCSELITYTETEAAELKTCFPDKPVIPARNSLYSSAQLSAYDIRDVARCTDLIMIGRLVADKKPLLGLAAFEQALPHLPDQTSLHVVGAGPQEDDVRAYLGAAELTDRVRLHGWVSDLAVLAPIFQRCRALLSPGYVGLNVTQALGFGLPVIYPRDDPHAPEIEALNPTNSIVFDTDDVDQCSRAIVAVYQGDWPFDSRRMADEIRSQYSTERMIQPFVALARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRF7</accession>
    <name>A0A132PRF7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845042.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12985"/>
    <dbReference type="EnsemblBacteria" id="KWX24919">
        <property type="protein sequence ID" value="KWX24919"/>
        <property type="gene ID" value="AFM11_05610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4312"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="178" mass="20060" checksum="7A890E59D2C0F165" modified="2016-06-08" version="1">MNSPIEPDTKDWTWVMSRPCPECGFDATAVHHTEVAARIRDDAAAWVPRLNQPGVAIRTRPGMWSTLEYGCHIRDVHRIFDHRVRLMLTEHDPQFPNWDQDATAIADDYGSQDPATVATELFESANTVAATYEQVPDDAWSRRGLRSNGSEFTVASIAIYHLHDIVHHAHDVTAPPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRU0</accession>
    <name>A0A132PRU0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845018.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12915"/>
    <dbReference type="EnsemblBacteria" id="KWX24907">
        <property type="protein sequence ID" value="KWX24907"/>
        <property type="gene ID" value="AFM11_05540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4298"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="319"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="450" mass="46702" checksum="86BE99AC5A1FE7C2" modified="2016-06-08" version="1">MTDLVETAALSGYFRQRDISSLATDLRAGRATSVELVEESLAAIDRLNPILNAFTTVDADAALAAARQADADLARGLDHGPLHGIPVSVKDLVDVEGQITTSGSAVHPDRPADADATCVARLRAAGAVIVGRNVLHEFAYGATGDRSLHGASRNPWDTDKISGGSSGGGAVATAAGMVPLAVGTDTAGSVRVPAALCGIVGFKPAYGAIPIDGVRPLAASLDHVGVFARTAADAAAGYAAMAGRAPDPDPRGPLLAWIDPTCIGPTDPAIVATVRTAMDQAGISAVGTELPFRAGELFAVLSVLQASEAYTEHADALADHRDDIDPEVVKRLIRGRDTPAWQYVRADRTRNMLRASIVELLGRFDVLAMPTVPTVATDLGRRAHVIDGQAVEVRSALLSLTSPWNLTGHPALSIPAGTVSGLPVGLQLITAPGREHLLFALADRVERAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS03</accession>
    <name>A0A132PS03_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 12">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFM11_06840</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 12"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845469.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28810"/>
    <dbReference type="EnsemblBacteria" id="KWX25131">
        <property type="protein sequence ID" value="KWX25131"/>
        <property type="gene ID" value="AFM11_06840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4567"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_2" evidence="15">
        <location>
            <begin position="19"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="16">
        <location>
            <begin position="428"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KWX25131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="526" mass="54379" checksum="9E08C2CBB76DB903" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS76</accession>
    <name>A0A132PS76_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_07175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845653.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17540"/>
    <dbReference type="EnsemblBacteria" id="KWX25189">
        <property type="protein sequence ID" value="KWX25189"/>
        <property type="gene ID" value="AFM11_07175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4635"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="263" mass="26669" checksum="EFC6BA6789DCE381" modified="2016-06-08" version="1">MTTLADPRYAGALRLDGKRALITGATKGIGADIARAFASAGARLVLSGRDAGELNAARSGLADEFGAEVRTEVIDLAHADGPLELAGRAADAFGGLDVLVNNAGISHPQPVIDTDPALFDATIAVNLRAPALLASAVGAAMVAAGTRGSIITVASAAALAPLPDHYAYCASKAGLVMATKVLARELGPHGIRANSVCPTVVLTEMGQRVWGDEAKSAPMIARIPLGRFAVPHEVSDAVVWLASDAASMVNGVDIPIDGGYTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS89</accession>
    <name>A0A132PS89_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_05450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844990.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12825"/>
    <dbReference type="EnsemblBacteria" id="KWX24892">
        <property type="protein sequence ID" value="KWX24892"/>
        <property type="gene ID" value="AFM11_05450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4279"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014342">
        <property type="entry name" value="Ectoine_EhuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03004">
        <property type="entry name" value="ectoine_ehuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="16"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="245" mass="26841" checksum="1AAA061411A45AD7" modified="2016-06-08" version="1">MFDNVGFFVDTIAQGLLLTVEATLGGIVIAAVLSFLAGLAMLSKSRIVRTLARIYVEIWRGTSEVVQLLWIYFVLPVLVGYQIVPMAAGIVVLGLNHGAYGAEIVRGAIQAVPRAQYEGCVALNFTPAQRMRRVILPQALVEMVPPFNNLFIQLLKSSSLLTMITVHEMTYQAREVLVNNYISDSPVIWTIVLLFYLALAVAITFVMRVLERKAAKMVGRQPPPRRGVLTRFGRGSVPAGAGRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSG4</accession>
    <name>A0A132PSG4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuA</name>
        <name evidence="5" type="ORF">AFM11_06925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28725"/>
    <dbReference type="EnsemblBacteria" id="KWX25263">
        <property type="protein sequence ID" value="KWX25263"/>
        <property type="gene ID" value="AFM11_06925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4584"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="552" mass="60467" checksum="05CFF9CB5C3DC6AA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSM3</accession>
    <name>A0A132PSM3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_07000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845898.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17715"/>
    <dbReference type="EnsemblBacteria" id="KWX25264">
        <property type="protein sequence ID" value="KWX25264"/>
        <property type="gene ID" value="AFM11_07000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4599"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="310"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="343"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="510" mass="52949" checksum="F575C84215CC2038" modified="2016-06-08" version="1">MFRADPLFRLTVDLLRPRLGRFLLASLFGVLSLGSALALAGISAWLITRAWQMPPILDLTVAVVAVRALGISRGVLGYCQRLASHDTALRAAANARTGLYRKLADASADDAMRLPSGELVARVGASVDELSDVLVRALLPIVVAAVLSCAAVGVIAIISPVAAAVLALCLLVAGVLAPAVAARAVAAAESVAAQHRASRDTATMLALEYAPELRVSGRLDEIITTAERHHRNWGDAADRAAAPAAVAGAMPSAAIGVSVLGAAIAGIALAPAVAPTTVAILMLLPLSAFEATTALPEAAVQLTRSRIAARRLHDLIAPDSHGRRRPHVPAVDLPPGGRLAVVGPSGSGKTTMLMAMAEKFDQKSRRAAFFAEDAHLFETTVRDNLLVVRGDATDAELLEALHRVGLTDWLSGLPDGLSTVLVGGAAAVSAGQRRRLLLARVLVSDFPIVLLDEPTENLDAADGQQFLTDLLTPGALVPADRTVVVATHHLPTDTDCPVIRCPQLGAAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT47</accession>
    <name>A0A132PT47_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844544.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20590"/>
    <dbReference type="EnsemblBacteria" id="KWX25516">
        <property type="protein sequence ID" value="KWX25516"/>
        <property type="gene ID" value="AFM11_04555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2790"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="259" mass="28646" checksum="0E85F31B85F5936B" modified="2016-06-08" version="1">MTNLTTLLPTKTTTPRYSVQLTTDPDRIDGAQRLRYAVLAEEGGRTASAFGLDADRFDEHCVHVLIEDNRSGELVACCRMLPSGGAIAAGDLCIAASFDIAALEPLRLSMLEFGRAVVRADHRNGAVVLMMWSAVLEYAYRYGYDHVLGCVTMPAFETSGRGRNVMHHVWSHLRRNYRAPDCYTVRPHRPVVIDALCLSYLAPHRQPELPALMRGYLRAGARICGEPAYDPVFGFACFPTLLSTTGDTYRPATESALYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT59</accession>
    <name>A0A132PT59_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844501.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20695"/>
    <dbReference type="EnsemblBacteria" id="KWX25500">
        <property type="protein sequence ID" value="KWX25500"/>
        <property type="gene ID" value="AFM11_04450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2766"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="100" mass="11329" checksum="215696AF4A016D10" modified="2016-06-08" version="1">MTQLDRTGAATTVTEQPDRFTIEVEGRSVGLADYHDRDGRRIFPHTEVLPQYRGRGLATILIAEALRSTRAAGLRVVPQCWMVAEYIDKHPEYADITDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT84</accession>
    <name>A0A132PT84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Propionyl-CoA synthetase</fullName>
            <ecNumber evidence="4">6.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prpE</name>
        <name evidence="4" type="ORF">AFM11_04270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844448.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20885"/>
    <dbReference type="EnsemblBacteria" id="KWX25474">
        <property type="protein sequence ID" value="KWX25474"/>
        <property type="gene ID" value="AFM11_04270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2732"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="64"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="514"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="626" mass="67533" checksum="27ECC4D806227E30" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTM5</accession>
    <name>A0A132PTM5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LpqV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844606.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20420"/>
    <dbReference type="EnsemblBacteria" id="KWX25547">
        <property type="protein sequence ID" value="KWX25547"/>
        <property type="gene ID" value="AFM11_04725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2826"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020377">
        <property type="entry name" value="Uncharacterised_LpqV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17301">
        <property type="entry name" value="LpqV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453624" evidence="2">
        <location>
            <begin position="30"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="152" mass="15396" checksum="C92891B0EBE65D42" modified="2016-06-08" version="1">MRSYTWVSRATAGAVAVAGLSLLVGCSSGDDKEQSQESSAPATTATTTAESPTPTAAPGEVAVSPGGVTTAVGADAQSTEEEYFQACHAAKVWMDEKGGDPKAQIEPYLASLQAPDAAPGPGTYNKPWAELEPARQAAVIVAVQAAADQLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTU7</accession>
    <name>A0A132PTU7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_00220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842126.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33330"/>
    <dbReference type="EnsemblBacteria" id="KWX25761">
        <property type="protein sequence ID" value="KWX25761"/>
        <property type="gene ID" value="AFM11_00220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.45"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="416" mass="46235" checksum="5EF9F89B2EF0E167" modified="2016-06-08" version="1">MSAPTMDDAAKVLADPTAYADDARLHAALTQPRADNPVAWVDNPPYRPFWAITKHADIMAIERDNNLFISAPRPLLATAAADDMAKEQLEAGMGLRTLIHMDDPHHRKVRAIGADWFRPKAMRDLKVRVDQLAKRYVDRMREIGPECDFVTEIAVHFPLYVIMSLLGLPEEDYARMHMLTQEMFGGDDEEYQRGKSLEDGLAVLLDFFAYFSKLTASRRANPTDDLASAIANGRIDGEPLSDVDTASYYVIVASAGHDTTKDAISGGLHALIENPSELARLREQPELMGTAVEEMIRWSTPVKEFMRTATADTTVRGVPIAEGESVYLAYVSGNRDEEVFADPFRFDVGRDPNKHLAFGYGVHFCLGAALARMEMNSLFTELLSRLESIELAGTPELSATTFVGGLKHLPIRYSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU65</accession>
    <name>A0A132PU65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconate 5-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.69</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.69" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844700.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25592">
        <property type="protein sequence ID" value="KWX25592"/>
        <property type="gene ID" value="AFM11_04990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2879"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008874">
        <property type="term" value="F:gluconate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="26807" checksum="EA1A78E80D12E229" modified="2016-06-08" version="1">MTQHGSFDLRGSTAVVTGSSGGIGRAIAAALAGAGAEVVVTGRRDTHVAETVEQIRSAGGSAAGYPLDVRSAQSVSALFDTLDREHRRIDILVNNAGVQLRKPLLEVTEEDWTSVLDANLTGAFRMGTQVARRLIAQRRPGKIINIASLTSSIARPGVGTYAASKGGLLMLTRAMAAEWGPHGLQANAIGPGVLATDMTAELTADPDYDAWLRRRTPAGRWGSAHDVTGAAVFLCSPASDFVNGQILYVDGGVTAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU85</accession>
    <name>A0A132PU85_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_00880</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33915"/>
    <dbReference type="EnsemblBacteria" id="KWX25880">
        <property type="protein sequence ID" value="KWX25880"/>
        <property type="gene ID" value="AFM11_00880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.182"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453600" evidence="13">
        <location>
            <begin position="26"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="14">
        <location>
            <begin position="81"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX25880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="439" mass="44167" checksum="D70DBE7BB466C870" modified="2016-06-08" version="1">MSAQYRLLAATFAMLSLVAAPAAGAVTPPAIDDALLPPAAPPAATHPTEQRGQCFGSTPRDVAEPRTPLALDAVWRLSRGGGQTVAVIDTGVTRHRLLPHLIGGGDYVSSGDGTSDCDGHGTIVAGIVGGAAADGFSGVAPDVSILAIRQSSNKFADASGSSGVGDVDTLAKAVRTAADLGATVINISSVACVAADDALDDRALGAALAYAVDVKNVVVVAAAGNVGGPGHCPEQNPAGEPDWDTVVSVATPAWYDDLVLCVGSVNRDGTASTFSLGGPWVDVAAPGEGIVSLHPDGERLIDTLGKSNPVSGTSYAAPIVSGIAALIRSRFPHLSARDVMRRIEDTAHRPPGGWNPYLGHGVVDPLAAVSDGGAPTSEPAPVAATSIAQPAVTPDDARSRRVAFGGAAVCAAATALLAITLSSRRLRAPTPRSQPVVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU98</accession>
    <name>A0A132PU98_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842368.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25844">
        <property type="protein sequence ID" value="KWX25844"/>
        <property type="gene ID" value="AFM11_00680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.139"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="27"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="436" mass="46458" checksum="978DFF2F6CEFF1D7" modified="2016-06-08" version="1">MELLTETGWAELPTTGEPALAEDVRCDVAVIGGGVGGMTAALRLAEAGADVALLEAQTCGWGASSRNAGYVTNSIAADPALLALLFRRSKVRALFEFAESAVEFTQNAIENRAIDCDFEKAGIVQAAVSKGQLRKARRNAKIMAEAGSSAEFVDGRDAGLPEGFLGGMQEGVGGTLNPAKYVLGLRSAVLASGARVFEHTPVRDVTDGGTGVTISTANGRVHAKQALLTANAYNKDLAITPPRLVSPVWTSLVETEPIAPERLDAIGWTSRAPMVTAHMILESYRVTPRNTIVFGTRRLETTKGPLLARTPSTPVVDDLLHGFRERFPGLHDIKPQRAWGGWIGMSSTWLPVAGEASPNVLYSLACNGHGFAQAQYVGHMLAGTLSGEPTPQDLKTIWHTGRFWPSFVSSPALHLGWLGDRLADRLARASQPTTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUJ0</accession>
    <name>A0A132PUJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842833.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25983">
        <property type="protein sequence ID" value="KWX25983"/>
        <property type="gene ID" value="AFM11_01575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.322"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021269">
        <property type="entry name" value="DUF2848"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11010">
        <property type="entry name" value="DUF2848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="230" mass="25207" checksum="DB6A3511AF005821" modified="2016-06-08" version="1">MPQLTFTLRDDEAVIVDVDTLLNAGYAGRSQADVTAHINELAELGVPAPTRIPCIYPIASYLAMQTENIDVQHELTSGEAEWALVVAGTGPDDLLLTAACDHTDRRLEQHGVAWSKQAAPDVLARRAWRLSTIADRLDEFTLTGTVETETGVDVIQQGTLTELLSPLFWIEELRSRDLLNPGTVLMSGTIPMRPEVNQFSTGWGVELRDPVTDEAISLSYSVRRTPPAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUK4</accession>
    <name>A0A132PUK4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844955.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25722">
        <property type="protein sequence ID" value="KWX25722"/>
        <property type="gene ID" value="AFM11_05180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2918"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="233" mass="25161" checksum="65C5E8BCF030CE2D" modified="2016-06-08" version="1">MIPNNTPAGRAAQRPEPVRAYSQPEIRRRRRAGLPIVNYGGGWSIVAEIAEVCEPLAQRIAASERPGRFSWRGSQVGVHDLVAAAHEAVGDITGWLAEADAHVKTKHLAGDPGKRRYAMTTLCDLAPRPALPDVTDAMIRDGSWAAALIEMAEPVDAGLADLLRRAHPPGAPALRGQLSRSERLDRLLRESLDRPAAELECRLDRADREAAKPSALAKAEAARAELEAMGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUT3</accession>
    <name>A0A132PUT3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843269.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35230"/>
    <dbReference type="EnsemblBacteria" id="KWX26118">
        <property type="protein sequence ID" value="KWX26118"/>
        <property type="gene ID" value="AFM11_02450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.502"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="67"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="190" mass="19977" checksum="080D2E71BB13EDF5" modified="2016-06-08" version="1">MRRLRTKLYLAAGACAAIAGYAAGVDVPWSLAIGVAVPLVLVTAPHFLAGAWDGARTPGPSEQRGAEMSGLEFEDHVARIARSCGLPVIMTPVTGDWGVDLIVGHRPNRVAIQCKRQSRPVGAGAVQEVVAGAPMQDCAKTMVVTNHEFTPAAHKLAALHGCELVGGAQLPRLKSIIRRVITEIPPDPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUW7</accession>
    <name>A0A132PUW7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843339.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35345"/>
    <dbReference type="EnsemblBacteria" id="KWX26141">
        <property type="protein sequence ID" value="KWX26141"/>
        <property type="gene ID" value="AFM11_02570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.527"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="311" mass="33616" checksum="24D1E7147BC12BC3" modified="2016-06-08" version="1">MDSVERTGTRTEESTPISEKVSFVIASRNRSAELAAVIHRLLDETECPITVVDNGSEDDSVEAVRRIASRSGGRVVLIGLKSNLGAVGRNIGVAACRTPYIAFCDDDSWWDPQAPARGAAIFDRYPNTAVLAARTEVWPQRRDDPMVEELANSALGHRPDLPGPSILGFLACSAMVRKSAFEAAGGFSEILHFRGEEQLLALDLAALGWHLCYCPELKAIHQPSSQRPATAAQDARSLRNAVLTTWLRRPMRQCVGATGSLLCAAARDGEHARAAAEAMVRLPAVLAHRRTLPAGVEDALAVLERGNGRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV35</accession>
    <name>A0A132PV35_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_00960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842513.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33990"/>
    <dbReference type="EnsemblBacteria" id="KWX25892">
        <property type="protein sequence ID" value="KWX25892"/>
        <property type="gene ID" value="AFM11_00960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.198"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="28"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="507" mass="54999" checksum="92AE187DFF2EEC48" modified="2016-06-08" version="1">MTVYARPGAEGALMSFEARYDNYIGGEWVAPVEGRYFENPTPVTGQVFCEVARSTEADVEKALDAAHAAAPAWGKTSPAERAVILNKIADRIEENLESIALAESWDNGKPIRETLNADIPLAVDHFRYFAGVLRAQEGSLSQIDEDTVAYHFHEPLGVVGQIIPWNFPILMAVWKLAPALAAGNAVVLKPAEQTPASVLYLISLIGDLLPAGVVNIVNGFGVEAGKPLASSNRIAKIAFTGETTTGRLIMQYASQNLIPVTLELGGKSPNIFFSNVLAAADDYQDKALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQGDPLDTETMIGAQASNDQLEKILSYIEIGKTEGAKLITGGERAQLGGDLNGGYYVAPTIFTGNNKMRIFQEEIFGPVVAVTSFTDYDDAISIANDTLYGLGAGVWSRDGNTAYRAGRDIKAGRVWTNCYHQYPAHAAFGGYKQSGIGRENHKMMLDHYQQTKNLLVSYSNKALGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVA9</accession>
    <name>A0A132PVA9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_01605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843643.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26253">
        <property type="protein sequence ID" value="KWX26253"/>
        <property type="gene ID" value="AFM11_01605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.330"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="151"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="298" mass="29991" checksum="A66634FE54DF2D31" modified="2016-06-08" version="1">MIVGALLLLGTLWGSAFPLIKVAAPAFGPVGTTHIRLAVAAVVLALIAAVRRELWRGVSKRFGAFALLAALNVAIPLTLVATAIVGLNASMAAILNATTPMFTILVAAAWLGQRITWSRTLGVAAGVFGVVILLGGASLTPDTGTALAAAASLTAALSYALGGTYARRAFPDTAPMTLALGQQVAATLLLIPVTVGATWAAAPPGPVTDAAITAVAVLGLGATACGYLLYFWIIRHAGPVAASTVTLLVPVAGSGLGVGWLGEPLTPALLLGLLVISTSVVLLTFDKPRITRPTAAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVE6</accession>
    <name>A0A132PVE6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02635</name>
        <name evidence="2" type="ORF">AWC31_35410</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843763.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35410"/>
    <dbReference type="EnsemblBacteria" id="KWX26293">
        <property type="protein sequence ID" value="KWX26293"/>
        <property type="gene ID" value="AFM11_02635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12144">
        <property type="protein sequence ID" value="ORX12144"/>
        <property type="gene ID" value="AWC31_35410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.540"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX12144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="142" mass="15358" checksum="BC20C5929555C776" modified="2016-06-08" version="1">MLHAKRLPRGTVDHTHPHDTLEFRVPARMDRLSTVRTVLAALAAFDDLDLDAVADLRLAVDEACAVLIDSAAPGALLTLVVEPHRDALVIHASTPRADAEIPALGGFSRHVLSALTDDVRTFHAGQVFGISLTTRRRWASAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PW91</accession>
    <name>A0A132PW91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35395"/>
    <dbReference type="EnsemblBacteria" id="KWX26292">
        <property type="protein sequence ID" value="KWX26292"/>
        <property type="gene ID" value="AFM11_02620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.537"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007251">
        <property type="entry name" value="Iron_permease_Fet4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04120">
        <property type="entry name" value="Iron_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="94" mass="10622" checksum="6DA1B196CFC2E16B" modified="2016-06-08" version="1">MACYVAAGAVVGFDHWWQTLIHSTAAVVTLPMLFVLQHTTNRETKAILIKLDELIQATTDARDDFMDLEKHEVREQEQLHDAHHHEGDDAASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAS9</accession>
    <name>A0A132PAS9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000052">
        <property type="protein sequence ID" value="KWX19435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067860003.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22490"/>
    <dbReference type="EnsemblBacteria" id="KWX19435">
        <property type="protein sequence ID" value="KWX19435"/>
        <property type="gene ID" value="AFM11_35870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6253"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="178"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="337" mass="35518" checksum="F208A1820945C0B8" modified="2016-06-08" version="1">MTDRILVVGAGAIGGVTAAHLARAGHDVVVLDANTEHVRLMNSPGLRFDELGETSIVPITAVDKPADLPGRFSYALVTLKAPYLDVALSPLVAGDLVDTYVSLGNGLVQNSVEQIVGPDRLVIGITEWGATNLGPGHLAQTTVAPFVIGEADGSDSQRIEKLRDILAAAAEVRISPRIVGQIWTKLLLNSTFSGLGAVSGMLYREVVAEPLGRELAYRLWTEAYDVADAAGIELDEIVGVQPDRLVVRSGADLERADAALRILMDRLGATKASMLQDLERGAITEVDVINGGVCLTAQKAGVTSPLNARIVELVHDCERGSRAPGRATLEALAEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAT1</accession>
    <name>A0A132PAT1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000054">
        <property type="protein sequence ID" value="KWX19431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067860037.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19431">
        <property type="protein sequence ID" value="KWX19431"/>
        <property type="gene ID" value="AFM11_35920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6261"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="273" mass="29963" checksum="7896DD5ACE681E18" modified="2016-06-08" version="1">MTASNELGEFLRSRRARLNPAEVGLRGAATSRRVAGLRREELAMLAGVSADYYARLEQGRARNVSEQVLTAVADALQLDDVERRHLNDLAHPSGAAARPAPKVRAALRSMVHALDPVPAVLHGPLLEVLAINRAGKALLTDFEAMPAAERNMVRWMFLDPNARRVYPDWAEIAAQMVAILRAAGNGPALAELVGELTAQSSDFARCWAEYRVYQHTHGPKRFHHDEVGTMVLNYETLRLPADPGLSVILYTADTGSPSAQRLTELVSSYRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAU4</accession>
    <name>A0A132PAU4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_35770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000049">
        <property type="protein sequence ID" value="KWX19451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859949.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31640"/>
    <dbReference type="EnsemblBacteria" id="KWX19451">
        <property type="protein sequence ID" value="KWX19451"/>
        <property type="gene ID" value="AFM11_35770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5890"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="353" mass="37323" checksum="50B1213BCA62B45C" modified="2016-06-08" version="1">MTTTTSTTNVELPALGEAVTEATITRWLKAVGDEVEHDEPLLEVATDKVDTEVCSPAAGILAQIIEPEDAVVEVGAVIAVISAAAPASIEAGPPEPENVPAAAEPVPAPQPAETPTDRVEKLPRIRRTIAQRMLASLQTSAQLTTVIEVDLTNVAAVRNRNKAEFHVRTGHKLSYLPFVVRAAVEGLAAHPVINSSLNADCTEVTYHSAVHLGLAVDSDKGLMVPVIRNAESMTLADLAEAIAASALAVRSGSIRPDDLSGGTFTITNTGSRGALFDTPIINQPQSAILGVGTVVERLVPARDELGNLLVKPSSMAYLSLSYDHRIIDGADAARYLATVRERLERGFDDADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAX5</accession>
    <name>A0A132PAX5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000049">
        <property type="protein sequence ID" value="KWX19454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19454">
        <property type="protein sequence ID" value="KWX19454"/>
        <property type="gene ID" value="AFM11_35800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="67" mass="7474" checksum="D212565D2D9FE756" modified="2016-06-08" version="1">MPSARQLVFEIDRPDGLASRLIHPILNEQNPFTTAITVMKAVVNDTVNVHHRQIVSLSERTDGGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAZ4</accession>
    <name>A0A132PAZ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_35560</name>
        <name evidence="8" type="ORF">AWC31_02690</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859802.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02690"/>
    <dbReference type="EnsemblBacteria" id="KWX19488">
        <property type="protein sequence ID" value="KWX19488"/>
        <property type="gene ID" value="AFM11_35560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11063">
        <property type="protein sequence ID" value="ORX11063"/>
        <property type="gene ID" value="AWC31_02690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5848"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX11063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="319" mass="33762" checksum="5B1C139799E2BF97" modified="2016-06-08" version="1">MTGVIGSRLLSTVLVLFGVSLIVFLLLQLVPGDPAVTILGSGATAEAVAALRTELGLDRSLPVQFFDYLGGLLHGDLGRSLTVNAPVTDIMVPRFANTMILTVAALVLCIVVAVPLGVIAAHKQYSIFDRASMVISLAGASVPVYWFGLLLIGVFAITLGWLPTSGMYNPRFPGGLGDLLAHLILPAIAAALVPLAVIARMTRSVMIDILQQDYIRTLRASGLSTTSVLWRHALRNALPPIVNIIGLQVGYLLGGVVFVEVVFGWPGLGQQLYTSITQRDIPVVQAGVLFIALAFVIINLIADGAVGLLDPRTRRKVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAZ7</accession>
    <name>A0A132PAZ7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="4" type="ORF">AFM11_35620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859851.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02630"/>
    <dbReference type="EnsemblBacteria" id="KWX19499">
        <property type="protein sequence ID" value="KWX19499"/>
        <property type="gene ID" value="AFM11_35620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="273" mass="28173" checksum="CCA8FA17AA7E935D" modified="2016-06-08" version="1">MTTALDLVFARVGGRTVLTRRRYRWPLLIGRVFDEPAQHGMGSVTVQNAAGTVIPGDVVRQRIGVVDAGWAVVRGQGATVVSGVPGRGEAVEDVCVRVGAGSRLLLDPPPRILTAHARYRQHTQVCVEPGGQAVFTDAVVLHPALTDEVFGSYASRVAITAADGALLALDAQVLATMPVVRRAPTAFGTVYIVGAGLDTAMTARTPALESVADLGSVYVGVTDLPNSAGWAVRIAASDGGALRTAIGAVIGLVTPCPAELLVPVRCPSSTLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB00</accession>
    <name>A0A132PB00_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_35570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859809.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02680"/>
    <dbReference type="EnsemblBacteria" id="KWX19490">
        <property type="protein sequence ID" value="KWX19490"/>
        <property type="gene ID" value="AFM11_35570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5850"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="31779" checksum="EB435EC97A5F3B01" modified="2016-06-08" version="1">MTNSLDVKKLSVDFHTDNGVVHAVKNADISVREGGILGLVGESGSGKSVTSLAVLRLLGTTRARITGGEILFRGENLLDKTDKEMRAIRGSHIGMVSQNALSALDPSFTIGSQLVEVIRLHQGVDKATARAKALEALELVALPDPKRRMKAYPHELSGGQRQRVVIAIALACRPELLLADEPTTALDATVQKQILDLLVTINRELGTSILLVTHDFGVVAHVCTDVTVMRRGDVLESGTADQVLNNPQHPYTQGLMRAVPRLHLDDQTRAIPRADRRLFEFHGDTTKETADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB14</accession>
    <name>A0A132PB14_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mercuric reductase</fullName>
            <ecNumber evidence="5">1.16.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hg(II) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFM11_35440</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + Hg + NADP(+) = Hg(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23856"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16170"/>
            <dbReference type="ChEBI" id="CHEBI:16793"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.1" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000044">
        <property type="protein sequence ID" value="KWX19519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010596913.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19519">
        <property type="protein sequence ID" value="KWX19519"/>
        <property type="gene ID" value="AFM11_35440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5821"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="7 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="17">
        <location>
            <begin position="9"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="16">
        <location>
            <begin position="356"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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        <location>
            <begin position="188"/>
            <end position="195"/>
        </location>
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            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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        </ligand>
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        <location>
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        </location>
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            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000896"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00003340"/>
        </source>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="479" mass="48722" checksum="38563ABDE1432B54" modified="2016-06-08" version="1">MTTTSPRADLAIIGSGSAAFAAAIAAVNLGKRVVMVERAAIGGTCVNVGCVPSKALLAAAEARHTAASADRFPGLAATGAPVDFAELIAGKNALVDRLRGEKYLDLAADYGWEIVSGTAVFTGTTDAPVLRVEQGADGPRVIDADQYLIATGAAPWAPPTDGLAEAGYLTSTTAMELDVLPGSLIVVGGNAIGLEQAQLFARLGTRVTVIEALDRLAPFEEPEISRAIAQVFADEAITVLTGATLDKALAEGGEKLVTVRTADGATTELRAAQLLIATGRRPDTPGLNLAAVGVRTDDRGAVVVDAHQRSSNPRIWAAGDVAGGPQFVYVAAAQGTLAAGNALGHAGRTLDYTALPRVTFTSPAIAAVGHTDSQAAAAGLRTESRLLTGANVPRALVNRDTRGVVKLVAEAGTGRVLGVHAVAEGAGDLITAAGYAITAGMTVDQLARTWAPYLTMAEALKLTAQTFTADVAKLSCCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB74</accession>
    <name>A0A132PB74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_35100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859653.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19568">
        <property type="protein sequence ID" value="KWX19568"/>
        <property type="gene ID" value="AFM11_35100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5748"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453165" evidence="3">
        <location>
            <begin position="16"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="124" mass="13190" checksum="6E54D2E2654371B6" modified="2016-06-08" version="1">MKVLLALVGMGCVMATLAVLVVVDLVVRYWPIVVLAATAWVAIRWWRTRATSGSSTPTADYRMVAPVVPASVPPVPCRVVAAAEEPLVIGDETGLRPPAPSQSLGWSMPATERASVGDRAVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC05</accession>
    <name>A0A132PC05_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpC</name>
        <name evidence="10" type="ORF">AFM11_33310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858629.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02405"/>
    <dbReference type="EnsemblBacteria" id="KWX19861">
        <property type="protein sequence ID" value="KWX19861"/>
        <property type="gene ID" value="AFM11_33310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4994"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX19861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="121" mass="13354" checksum="CF8514F4BA3E51D7" modified="2016-06-08" version="1">MADLNVEIVAVERELWSGPATFVFTRTTAGEIGILPRHIPLVAQLVDDAMVRVEREGEDDLRIAVDGGFLSVTEETVRILVENAQFESEIDADSAKQDSESDDERTAAWGRARLRALGQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC41</accession>
    <name>A0A132PC41_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858745.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19901">
        <property type="protein sequence ID" value="KWX19901"/>
        <property type="gene ID" value="AFM11_33525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5038"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453008" evidence="2">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="120" mass="12812" checksum="9F56BBB382DB2E96" modified="2016-06-08" version="1">MNKLIVGALAAGALGGAIAFAAPASAAPNCDSVIDKINSEEGYTPSSTEAWTCAVPIQANAWQTFPGQLRENWTSFPGELRDNWVNYPKELRDGWTSFPDKLRDGWTPGDEGAEAADAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCI7</accession>
    <name>A0A132PCI7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858456.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32440"/>
    <dbReference type="EnsemblBacteria" id="KWX20040">
        <property type="protein sequence ID" value="KWX20040"/>
        <property type="gene ID" value="AFM11_32995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4929"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="37"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="34055" checksum="B23891F42BEDA22D" modified="2016-06-08" version="1">MTVSEPVPHVERAMGESVSSPAAEKRRRRGASIDDGLMGVALLAGPANVIMQLARPGVGYGVLESRVDSGRVDLHPIKRARTTFTYLAVATRGSDQQKAAFRRAVNKAHAQVYSTEDSPVKYNAFDKDLQMWVAACLYKGGVDVYRMFIGEMDDETADRHYQEGMALGTTLQVPPEMWPADRAAFDKYWQENLDNVHIDDTVREYLYPIAVGRLRGMALPGPLQRWSENLTGLITTGFLPQRFRDEMRLPWDPQRQQRFNRIIAVLRTVNNLLPSVLRQFPFNLLLRDLDWRVRTGRPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCL8</accession>
    <name>A0A132PCL8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858079.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19540"/>
    <dbReference type="EnsemblBacteria" id="KWX20069">
        <property type="protein sequence ID" value="KWX20069"/>
        <property type="gene ID" value="AFM11_32415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4811"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="407"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="501" mass="52710" checksum="82274EE91218BCAE" modified="2016-06-08" version="1">MSISLLLEMASSGNPDRTAVVSDDIRVSVGELSELADGGAGTIAASGAAHVAYVGTGGVLLPLLLFASARAGVPFTPLNYRLSAEGLRELIDRLPEPLVVADAEYADVVAGAGKRVITSEEFLAAARSSEPAEEFADPDAVAVVLFTSGTTSRPKAVELTHNNLTSYITGTVEFDSAAPEDAALICVPPYHIAGVSAAMSNLYAGRKMVYLRNFDAGRWVELVRAEGVTSATVVPTMLDRIVTALETAGTELPSLRSLAYGGSKVALPLVRKALQLLPGVGFVNAYGLTETSSTIAVLGPDDHRAALAADDAAVARRLGSVGQIVPGIEVQIRADDGTVLGPGETGELFVRGEQVSGRYTEIGSVLDADGWFPTKDVAMLDEDGYLFIGGRSDDTIIRGGENIAPAEIEDVLVEHPDVRDVAVVGPEDPQWGQIIVAVVVPAEGAAPDTDELREHVRKQLRGSRTPDRVVFRDELPTNATGKVLRRQLVDELQPIAKESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD17</accession>
    <name>A0A132PD17_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857923.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31685"/>
    <dbReference type="EnsemblBacteria" id="KWX20194">
        <property type="protein sequence ID" value="KWX20194"/>
        <property type="gene ID" value="AFM11_32165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4760"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="42"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="471" mass="51336" checksum="2D9A1940C9ABEE27" modified="2016-06-08" version="1">MPTGGSTVGDPTKFINGDVSFWYRSIGLPKRRPALPGDQEADVCIVGAGLTGLWTAYYLKREQPDLRIVLLEREFAGFGASGRNGGWLSAELAGSRDAYASTHGREGVVDLMRAMRGAVDEVISVAKAEGIDADIAKDGLLHVARTRAQLGRLYESVRYEQQWGAAPEDFVALSRDEMDDRIRVAGALGGMFSPHCARVQPAKLVLGLARAVEAAGVTIYEGTTVTGIEQGRAITDRGVVHAPIVLRCLEGFTATLEGQRRDWLPMNSSMIVTAPLTPEAADQIGWRGAELLGDYAHGYMYAQRTADNRIALGGRGIPYRFGSKTDTNGATQQWTINALTELMHDMFPATASIPIVHAWCGVLGVPRDWTATVDLDPVTGLGTAGGYVGSGLTTTNLAGRTLADLVLKRDTPVTRLPWVGRRVRRWEPEPLRWLGVQSMYVLYRMADRRETERDLPKTSRIARIANMITGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDB7</accession>
    <name>A0A132PDB7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_31230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857401.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25380"/>
    <dbReference type="EnsemblBacteria" id="KWX20217">
        <property type="protein sequence ID" value="KWX20217"/>
        <property type="gene ID" value="AFM11_31230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4151"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="135"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="247"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="406" mass="43508" checksum="19CF80E86A8F9CF6" modified="2016-06-08" version="1">MAINLEMPRKLQAVIEKGHQGAAEMLRPISRKYDLAEHAYPVELDTLANLFEGISSAKTISFAGAEAFRDDANGDGNKTTVNGANMSALLNALEISWGDVALLLSVPRQGLGNAAISSVATPEQLERLGKDVWAAMAITEPGFGSDSAAVSTTAVLDGDEYVINGEKIFVTAGSRATHIVVWATLDKSLGRAAIKSFIVPREHPGVTVERLEHKLGIKASDTAVLRFENARIPKDNLLGDPEIHVEKGFAGVMETFDNTRPIVAAMAVGIARAALEDLRAILTDAGVEISYDKPAHAQSAAAAEFLRMEADWEAGYLLTVRSAWQADNSIPNSKEASMGKAKAARVASDITLKAVEMAGTTGYSEQTLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSAELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDI7</accession>
    <name>A0A132PDI7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857267.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26770"/>
    <dbReference type="EnsemblBacteria" id="KWX20389">
        <property type="protein sequence ID" value="KWX20389"/>
        <property type="gene ID" value="AFM11_31060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4115"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="91" mass="9907" checksum="4911D881DD05625F" modified="2016-06-08" version="1">MFHVLTTTYLKPLDVVEQTRPAHIAWLKEEVAAGRILLAGRQETPTGAVLITGDISAEEAQSIIDRDPYTLAGLVSVERVSFNGSFRAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDK1</accession>
    <name>A0A132PDK1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_31175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857334.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26885"/>
    <dbReference type="EnsemblBacteria" id="KWX20408">
        <property type="protein sequence ID" value="KWX20408"/>
        <property type="gene ID" value="AFM11_31175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4139"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="6">
        <location>
            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="263" mass="27736" checksum="67B20C2230D2B2C4" modified="2016-06-08" version="1">MTNIVVLIKQVPDTWSERKLSDGDFTLDREAADAVLDEINERAVEEALLIKEREGGDSTVTVLTAGPERATEAIRKALSMGADKAVHLKDDGLHGSDVIQTAWALARALGTIEGTELVIAGNEATDGVGGAVPAVIAEYLGLPQLTHVRKLNVEGGKVTAERETDEGVFTLEASLPAVVSVNEKINEPRFPSFKGIMAAKKKEVTVLTLAEIGVEADEVGVANAGSKVLSSTPKPPKTAGEKMTDEGDGGTKIAEYLVAQKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDM0</accession>
    <name>A0A132PDM0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_31075</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-D-serine = D-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24873"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58680"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-serine = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857395.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26785"/>
    <dbReference type="EnsemblBacteria" id="KWX20429">
        <property type="protein sequence ID" value="KWX20429"/>
        <property type="gene ID" value="AFM11_31075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4118"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX20429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="413" mass="43695" checksum="3761BBEDC6AD416E" modified="2016-06-08" version="1">MGTSRERSSVLITVTGVDQPGVTSALFEVLSRHKVELRNVEQVVIRGRLTLGVLVAVPADIADGDGLRSDVEAAIHGVGLDVVIERSDDLPVMREPSTHTIVVLGRPITAGAFSVVARAVAELGVNIDFIRGVSDYPVTGLELRVSVPSGAAYGQLQTALAKVAVDEGVDIALEDYSLSRRAKRLIVFDVDSTLIQGEVIEMLAARVGAEAAVAEVTEAAMRGELDFAESLHRRVATLAGLPAEVLDDVAEQLELTPGARTTIRTLRRLGFHCGVVSGGFRQVIEPLAHELMLDYVAANELEIVDGKLTGRVIGSVIDRPGKAKALRDFAQQVGVPMEQTVAVGDGANDIDMLAAAGLGVAFNAKPALREVADASLSHPYLDTVLFILGITRGEIEAADAVDGVVRRVDIPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDU1</accession>
    <name>A0A132PDU1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00545"/>
    <dbReference type="EnsemblBacteria" id="KWX20506">
        <property type="protein sequence ID" value="KWX20506"/>
        <property type="gene ID" value="AFM11_30540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4008"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="16603" checksum="8C8A52FF3A781CEA" modified="2016-06-08" version="1">MWYPRSWQQCSVAGAVAVGVGLAVGIPSALVPNPWFARMTAVPGWGYAAWILIAVMSAVLAATYVGDASATSTTSRRTGIVANIGSILAVGCPVCNKLVVATLGVSGALNMWAPVQPVIAAVSVSLLGWALWQRISSRRACPAPSDVGRVTQSVTAALDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDZ3</accession>
    <name>A0A132PDZ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20550">
        <property type="protein sequence ID" value="KWX20550"/>
        <property type="gene ID" value="AFM11_29545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3801"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1307" mass="140794" checksum="BFE064AA31E2E77A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE02</accession>
    <name>A0A132PE02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29600</name>
        <name evidence="6" type="ORF">AWC31_24940</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856462.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24940"/>
    <dbReference type="EnsemblBacteria" id="KWX20560">
        <property type="protein sequence ID" value="KWX20560"/>
        <property type="gene ID" value="AFM11_29600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14451">
        <property type="protein sequence ID" value="ORX14451"/>
        <property type="gene ID" value="AWC31_24940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3811"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX14451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="223" mass="25332" checksum="4D3E04A2468A32A0" modified="2016-06-08" version="1">MTTYEPQRALRKDAERNRQRVLDAARELFAEKGLEATLNDVARHANVGVGTVYRRFATKEELLDAVFEDGIDQVVALAESALEYEDSWDGFVWFVEHMCELTATDRGLREMVYSKAYGGCGVESSRLRLIPPISKLVERARNDGHLRPDVEHTDMPILGLLAGTVSEWSGHVKPELWRRYVALLLEGMRRRDGQPRLQVEALCEERMEAAMQGWRPAGCPMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE54</accession>
    <name>A0A132PE54_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit C</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NADH dehydrogenase I subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NDH-1 subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoC</name>
        <name evidence="5" type="ORF">AFM11_29945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856635.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25285"/>
    <dbReference type="EnsemblBacteria" id="KWX20619">
        <property type="protein sequence ID" value="KWX20619"/>
        <property type="gene ID" value="AFM11_29945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3881"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0874">Quinone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="4">
        <location>
            <begin position="97"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="238" mass="26346" checksum="80EA3E6416CA33A6" modified="2016-06-08" version="1">MSTSNGSSNGTNGIRNGIGDTPEVIGVRRGMFGAEGTGDTSGYGRLVRPVALPGSSPRPYGGYFDEVVDQLAEVLGEERYAVSIERVVVYRDELTLEVSRVQLPAVASVLRDDPALRFELCLGVSGVHYPDDTGRELHAVYPLMSITHNRRIRLEVAAPDADPHIPSLYAIYPTTDWHERETYDFFGIVFDGHPALTRIEMPDDWVGHPQRKDYPLGGIPVEYHGAQIPPPDQRRSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE71</accession>
    <name>A0A132PE71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29975</name>
        <name evidence="3" type="ORF">AWC31_25315</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856653.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25315"/>
    <dbReference type="EnsemblBacteria" id="KWX20625">
        <property type="protein sequence ID" value="KWX20625"/>
        <property type="gene ID" value="AFM11_29975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14515">
        <property type="protein sequence ID" value="ORX14515"/>
        <property type="gene ID" value="AWC31_25315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3887"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX14515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="209" mass="22435" checksum="ADCD989C82EECAC3" modified="2016-06-08" version="1">MDTTPALSLFDEAYESRTAPWVIGEPQPAIVELERRGLIRGKVLDAGCGTGEHTMLLTRLGYDVLGIDFSPQAIAQARENAAQRGVDARFAVADATRLDAEPGYDTIIDSALFHIFDDTDRPAYVASLHTACRPGGYVHVLALSDAGRGFGPEVSEDVIRGAFADGWELEALDTTTYRGVVGPAQTEAIGLPAGSHVDEPAWLARARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE85</accession>
    <name>A0A132PE85_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20537">
        <property type="protein sequence ID" value="KWX20537"/>
        <property type="gene ID" value="AFM11_30610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4023"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="42"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="21652" checksum="9CC7A1E4822B6743" modified="2016-06-08" version="1">MHPLHRATGPDDLYDTKPPWDIGRPQQVFQDLADAGRIVGRVLDIGCGTGEHALMAAARGCETVGVDQSARALELAKAKAGRRGLAVRFVRHDALELAELGERFDTVIDSGLFHIFTEPARGAYVASVASVVDPGGTLFVLGFSDREPGDWGPQRLTRNQIITAFSDYWRIEAIEPATLDITVAPHRIAAWLVELTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEB9</accession>
    <name>A0A132PEB9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_30675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857078.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26395"/>
    <dbReference type="EnsemblBacteria" id="KWX20322">
        <property type="protein sequence ID" value="KWX20322"/>
        <property type="gene ID" value="AFM11_30675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4036"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="21500" checksum="D57BE552421DB904" modified="2016-06-08" version="1">MTARTDRRRSDAYANESRIIAAAREIFAADGAAATLTQVAARAGVGNATLYRHFPNRQALAAAVYEDVFATEIEPVVMELVDSDAPREAFIDVIERMAELMYAQRPLLPSLDHLTELTTRLFGRKRELLEAVVRRGQEVGELRADLTVEDVPTFVAMVTAASVALEQPPALRRRYLSLMLDALNPADAQPLPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEQ3</accession>
    <name>A0A132PEQ3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="10" type="ORF">AFM11_28640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856202.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32870"/>
    <dbReference type="EnsemblBacteria" id="KWX20801">
        <property type="protein sequence ID" value="KWX20801"/>
        <property type="gene ID" value="AFM11_28640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3608"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="8">
        <location>
            <begin position="32"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="9">
        <location>
            <begin position="207"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX20801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="496" mass="55127" checksum="194119DF3A9C698B" modified="2016-06-08" version="1">MAPDKPSSIAYPAPGSRPLRHDNEALPPHVIVLFGATGDLAKRKLLPGLAYLEQSTFSPDIRVVATSLEDFTDEQFLKHAKEAIDQFASRKPTDEQWASFASKVHYVPQSAGPQALAAAVAAAEAELGADARRLHYLSVPPKAAQSVITMLKDADLVKRAKVVMEKPFGTDLESAVLLNAFVHKTFKESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNRNFIDHIQIDIPEKLGLDQRANFYESTGAFKDMVVTHLFQVMAFVVMEPPTALEPRAISEEKNKVFRSMLPINPAEVVRGQYQGYRDEVGVAPDSETETFIALKVGIDNWRWAGVPIYLRTGKKMAEGQRIISIAFKEAPRTMFPAGSGVGSQGPDHLTFDLADESKVSLSFYGKRPGPGMRLQKLSMQFSTEESGAAADVLEAYERLILDAMRGDHTLFTTAEGIESLWERSAPLLEDPPIVKMYPVGTWGPNAIHQLIAPNAWRLPFERVWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEV4</accession>
    <name>A0A132PEV4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid replication protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20522">
        <property type="protein sequence ID" value="KWX20522"/>
        <property type="gene ID" value="AFM11_30175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3931"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="384" mass="42609" checksum="679A8F8C9BC0B166" modified="2016-06-08" version="1">MPPPSSFVNLELEADAYAGVACWSGGPARWAHVTVPIAYELRYKAIRPQMCNGGIDKHTLVLVAAALARFADFDTGRNSRPSNTQLALCTCLSVRTVQRARECLRLLGVATEVLRGRQRTLTERMASWRMGDRHRGWASVWALHDLALVNKVIHSLSSHLGRSHFTTETTSSERTLTTRGRAKRTRHGASRRRAPDKDGLRLATQWRASPGAPRWCQRYSADSWAAMLAAPAAAGWNARDLTQLVRDWLGTGRRISDSPPRPIALLGTLLAWHLSHNTLLDRPAALDEAREAAELAAVAERKANQAQAHVTFLAEREQGRAALASEGHAWARREAARLAKQSAGRRTEAARRDHEHRRTTLDTARQSAPPRRIHDGFLKSDADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEW1</accession>
    <name>A0A132PEW1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855653.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10200"/>
    <dbReference type="EnsemblBacteria" id="KWX20879">
        <property type="protein sequence ID" value="KWX20879"/>
        <property type="gene ID" value="AFM11_27665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3407"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="192" mass="21094" checksum="DE6F71189DC87B90" modified="2016-06-08" version="1">MTATYTFDVFSSLDGYGTAGGDWTGYWGKQGPELLDHRLALYSEPARMVFGANTYRVFAKMVASGGENSEVRDPWVTRMRNTPTTVVSTTLKEPLDWPNATVASGDAVDVVARLKEKSEVPLRSHGSLSMNRALMAAGLVDRVRVTLFPVITGKTGLNPIFEGGADFDLELIESRTLDGRIQELTYRPHLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF18</accession>
    <name>A0A132PF18_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25130"/>
    <dbReference type="EnsemblBacteria" id="KWX20592">
        <property type="protein sequence ID" value="KWX20592"/>
        <property type="gene ID" value="AFM11_29790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3850"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="285" mass="30945" checksum="1477C9346A060D43" modified="2016-06-08" version="1">MTTRSLPEILNGAPLTAVGVAVIRARESARADRLYDDPYARRFVEAAEQAYLSPNAPAGAAETWGSVLRLADVMYEPRTLGVRIADDALLQAAAEGRTQIVLLGAGLDTHAYRLSWPRAVHLFEIDLPQLFAFKEPVLEGIRPACDRHVVPADLGGSEWPKVLLDSGFQPEVPTHWVDHALMTLPTDVARAGVRAVTELSAPGSRYGFPVMAGAAFRNTLRSVAAEGLYRDMPNTERGLGEDAREWLESIGWTTSFKSTAELTEGYPRQVAAEDSGGHVVATRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF22</accession>
    <name>A0A132PF22_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855841.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10630"/>
    <dbReference type="EnsemblBacteria" id="KWX20938">
        <property type="protein sequence ID" value="KWX20938"/>
        <property type="gene ID" value="AFM11_28085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3492"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="304" mass="32884" checksum="B98E4D28AEB5848D" modified="2016-06-08" version="1">MVMPIDRPKLEGNVAVGDGRQLGFAEFGDPQGRAIFWLHGTPGARRQIPTEARVYAEQNHIRLIGVDRPGIGSSTPHQYESVLDFATDLRTIADTLGIDKLAVVGLSGGGPYTLACAAAMPDRVVAAGVLGGVAPTVGPDAISSRLMQLGAVVAPVIQVAGAPIRLAASGLIRLIRPVASPALEIYARLSPEGDRRMLARPEFKAMFLDDLLNGSRKQLAAPFYDIVVFERDWGFRLDEVKVPVRWWHGDHDHIVPFTHGQHVVSRLPEARLTELPYESHLGGLGCAQEIMGTMIDIWDAGKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF73</accession>
    <name>A0A132PF73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-succinylbenzoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855781.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10495"/>
    <dbReference type="EnsemblBacteria" id="KWX20924">
        <property type="protein sequence ID" value="KWX20924"/>
        <property type="gene ID" value="AFM11_27975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3469"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041338">
        <property type="entry name" value="OSBS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18374">
        <property type="entry name" value="Enolase_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="2">
        <location>
            <begin position="80"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="321" mass="33349" checksum="EAD756D835EE8B03" modified="2016-06-08" version="1">MQTLIDFDNAPIFAIPLADGAGTAGVREGMLIEGPQGWGEFSPHPDDHATVRWLTAALEPSTVGWPDPVRGRIPIAVTVPAVDPEAAHRIVTQAHCRTASVDVGAGVLAADIARVEAVRDALGASGTLRCDARGRWDPDAAAVAIPALDVAAAGLEFVEQPCRTLPELAAVRRRVDVRIAVDESVRDADDPVRLRLGDAADIVVLTCGPLGGARRSLRVAEATELPCVVSSALETSIGLAAGLALAGALPELPFACELGTRPLLGGDLVAASRSLVAVDGYLPVAPMPPAPKPDLLGRYALSDPQRAAWWRDRLRAAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF98</accession>
    <name>A0A132PF98_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_27730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855679.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10265"/>
    <dbReference type="EnsemblBacteria" id="KWX20887">
        <property type="protein sequence ID" value="KWX20887"/>
        <property type="gene ID" value="AFM11_27730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3420"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="162"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="229" mass="24691" checksum="493CFAE30D76B933" modified="2016-06-08" version="1">MTSASNHDLAVRMAELARDVAVPAALEDVLRTTTKAVLDLVPGAQYAGMLLLGTGGKYETLAPTSDLMYELDHIQISTGEGPCVQAAVGDLIVRTDDFEHEQRWPVYTPKVLELGVRSSLSFMLYTTRRNAGALNMFSSEPHAFDAESEAIGSVLAAHAAAAIVAGRHGEQLQTALSSRDLIGQAKGMIMERYNVDAVRAFEMLRQLSQSSNVKLVDVAKQVIETRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFA0</accession>
    <name>A0A132PFA0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06690"/>
    <dbReference type="EnsemblBacteria" id="KWX21010">
        <property type="protein sequence ID" value="KWX21010"/>
        <property type="gene ID" value="AFM11_26840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3239"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="31413" checksum="39DE9B0AAA84AB67" modified="2016-06-08" version="1">MHKMSIYHVEAGEGEPVLLLHGYPQSASCWRHQIPTLAARHRVIAPDWPGFGRSDPPPTPATYDAEVERIGELADSFGLDRFNLVAHDYGGFLGLGYTLRHPERVLRLALLNTRAHSIFRPWFYHFSRGQRWAVTNTPGLARRLPLSRIHQLFLRPYRRLGCWDSAIEHEYLDWMDTPQGRHTFVDFFTNYHLPVVPWLAEGLNTIACPTAVIWGDRDRYIPVRTAFELADRIPNATLTRLRGADHYVMEERPAEVTEALVELLARPCVVSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFM9</accession>
    <name>A0A132PFM9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855549.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06905"/>
    <dbReference type="EnsemblBacteria" id="KWX21135">
        <property type="protein sequence ID" value="KWX21135"/>
        <property type="gene ID" value="AFM11_27060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3286"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="210" mass="21740" checksum="66E51653C03AC73F" modified="2016-06-08" version="1">MLFDLDGTLTDSAEGIVSSFRHALQAVGANVPDGDLASRIVGPPMHHTLRDMGLGEHADAAIAAYRADYTSRGWAMNTLFDGIPALLADLRAAGVRLAVATSKAEPTARLILEHFGLDGYFEVIAGASPDGTRAAKADVVAHALAQLQPLPERVLMVGDRVHDVEGAAEHGIETVVVGWGYGAADFAGPAAVAARAQVATVEALRGVLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGA1</accession>
    <name>A0A132PGA1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854560.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36015"/>
    <dbReference type="EnsemblBacteria" id="KWX21350">
        <property type="protein sequence ID" value="KWX21350"/>
        <property type="gene ID" value="AFM11_25880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3040"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="155"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="497" mass="52648" checksum="C2444BA588C282C9" modified="2016-06-08" version="1">MIIEPGVVDAIGTDLRAAQYTVDGVADLLGADVNAALGRGVWWPALRATNAAPADRQRLAVLVRLFLLGSDESREQVETALPSVSVEALAANGVVEVSDGAVRAALDIRPHSDGAHDLIVVSDQDAALRSGPLRHDHVLGIGGASISLARAVIRTPVNRALDLGTGCGIQALHLDAHCAEVVATDTNERALALAAATARLNGMSWDLRHGSLFEPVAGERFDLIVSNPPFVVGSGARDYIYRDSGIAGDLLCQSLIEQVGDHLLPGGTAHIMANWIVGSESSDWRDRVRGWLAGTGLHAWVVQRELADPISYVSLWLADAGETPEQMADRGGQWLDWFAEQGIAGIGMGLISLRAPRHGERPEEILEEITAADELVTGSEVDAFFARRAYLRDTSDDQLLAARLSTAPVFLEEQSLPGPDGWQQVGAAVRRPGGPAAVIGVDEVLRALLAGCRGEVPLGTLIELLATHHGVDADALAEAALPEVREAIGRGILYQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGB3</accession>
    <name>A0A132PGB3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein LpqB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lpqB</name>
        <name evidence="8" type="ORF">AFM11_25970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LpqB lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854613.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35930"/>
    <dbReference type="EnsemblBacteria" id="KWX21366">
        <property type="protein sequence ID" value="KWX21366"/>
        <property type="gene ID" value="AFM11_25970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3059"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01373">
        <property type="entry name" value="LpqB_lipoprot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023959">
        <property type="entry name" value="Lipoprotein_LpqB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008865375" description="Lipoprotein LpqB" evidence="6">
        <location>
            <begin position="23"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="7">
        <location>
            <begin position="198"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="586" mass="61473" checksum="ED2A6C0D3A84E5D4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGF6</accession>
    <name>A0A132PGF6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_25975</name>
        <name evidence="12" type="ORF">AWC31_35925</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854744.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35925"/>
    <dbReference type="EnsemblBacteria" id="KWX21410">
        <property type="protein sequence ID" value="KWX21410"/>
        <property type="gene ID" value="AFM11_25975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12162">
        <property type="protein sequence ID" value="ORX12162"/>
        <property type="gene ID" value="AWC31_35925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3060"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="231"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="298"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX21410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX12162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="550" mass="60102" checksum="F17E33F98ABE0FFB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGR2</accession>
    <name>A0A132PGR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854885.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22950"/>
    <dbReference type="EnsemblBacteria" id="KWX21182">
        <property type="protein sequence ID" value="KWX21182"/>
        <property type="gene ID" value="AFM11_26365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3141"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="203" mass="22051" checksum="6DEC71B7766018CA" modified="2016-06-08" version="1">MTTALTGAGSSTGTDAFRLRLLDGLTAAINDKGYRDTTVADIVRHARTSKRTFYDQFASKEECFIELLRANNAALVTRIRGAVDADAPWQDQIGQAVGAYVDHIESAPAITLSWIRELPALGSAARPLQRAALRELTDLLIELSDSAGFRHAELPTLTRPMAIILLGGLRELTALIVEDDRDIREIYEPALAASKAILGPRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGT5</accession>
    <name>A0A132PGT5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_25075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854344.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27395"/>
    <dbReference type="EnsemblBacteria" id="KWX21559">
        <property type="protein sequence ID" value="KWX21559"/>
        <property type="gene ID" value="AFM11_25075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2376"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="118"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="350" mass="37203" checksum="141FA9337DD19F9C" modified="2016-06-08" version="1">MLLGRATKFTLNAIPNISDRRKRLLLGGRTVTIDGNTLDTTLQFMLAAQQSAGLAGLVADFTPVSGVAVSRAQLRTTAAMMPGSIHVDVSEISIPGPAGPMTARRYMPVDAGPVNALLLFFHGGGFVIGDLDTHDGLCRLICRDGGIQVVSVDYRLAPEHKAPAAAEDAYAAYQWALDHAAGLGATHIVVGGDSAGGNLAAVVSQWARDDELPLPALQLLLYPVTDFSSETRSRTLFSDGYFLTRRDMDWFRDHYLDGADVTAEDPAVSPLLAEDLSGLPPALVITAGFDPLRDEGNRYARAMRDAGVLVDLREERSLIHAFANFFPLGGGSAKAAAAMISALRAHLSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH61</accession>
    <name>A0A132PH61_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853770.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23625"/>
    <dbReference type="EnsemblBacteria" id="KWX21675">
        <property type="protein sequence ID" value="KWX21675"/>
        <property type="gene ID" value="AFM11_24495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2260"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="17541" checksum="2832EA8D1E324564" modified="2016-06-08" version="1">MEIRAAEAADIAAIAPFFRAIVADGESYTYPDDMTDAQIREAWLAAPPWHTIVAVVDGVVVGTARMGPNKPGRGDHVGTASFMVDPASPARGVGRAMGQWVIDWHRENGYSAIQFNAVVETNVRAVALWQNLGFRIIGTVPRAYRSRTHGPVGLHIMYLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHG2</accession>
    <name>A0A132PHG2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28065"/>
    <dbReference type="EnsemblBacteria" id="KWX21789">
        <property type="protein sequence ID" value="KWX21789"/>
        <property type="gene ID" value="AFM11_23340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2023"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="556" mass="55370" checksum="3D7106289CF107F5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHH8</accession>
    <name>A0A132PHH8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853199.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28180"/>
    <dbReference type="EnsemblBacteria" id="KWX21809">
        <property type="protein sequence ID" value="KWX21809"/>
        <property type="gene ID" value="AFM11_23455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2046"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017519">
        <property type="entry name" value="CHP03085"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03085">
        <property type="entry name" value="TIGR03085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="209" mass="22202" checksum="75EB11DE5F35637D" modified="2016-06-08" version="1">MSSIAQRERAALVESMRAAGPDAPTLCEGWNARDLAAHLVVRERRLDAAPGILVPKLAGYTAKVQQQVTDSTDWATLVDQIASGPPLFSPFKVLDPLVNVAEMFIHNEDVRRAQPDWEPRVLDDATVNALSRQVATMARMAMAKSPARVSLRTPAGKSLATVGSGGPAVTVTGEPGELLMFAAGREQARVTFGGPDDAVAALRSAHRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHM4</accession>
    <name>A0A132PHM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_23730</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853346.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29915"/>
    <dbReference type="EnsemblBacteria" id="KWX21858">
        <property type="protein sequence ID" value="KWX21858"/>
        <property type="gene ID" value="AFM11_23730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2103"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX21858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="259" mass="28344" checksum="DBB9689238362903" modified="2016-06-08" version="1">MNIRPLHQSVRPSPVFLAVVAITIGGGVLAWLAADNVRPLSYVGVFILVIAGWLVSLCLHEFGHAFTAWRFGDHDVAVRGYLTLNPLKYSHPMLSLGLPVLFIALGGIGLPGGAVYVRTSWMTARQKTLVSLAGPAANLVLAVVLLGLTRMFYDPAHGVFWSGVAFLGFLQVTALVLNLLPIPGLDGYGALEPHLKPETQRALEPVKQWGFFILLILLIAPALNRWFFGIVYWFFDFSGVSSYLVSVGGQLTRFWSAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHN5</accession>
    <name>A0A132PHN5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_23185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853059.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27950"/>
    <dbReference type="EnsemblBacteria" id="KWX21764">
        <property type="protein sequence ID" value="KWX21764"/>
        <property type="gene ID" value="AFM11_23185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1989"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453089" evidence="2">
        <location>
            <begin position="24"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="83"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="546" mass="60394" checksum="E168BCD6B8A224AE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI01</accession>
    <name>A0A132PI01_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="22">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="22">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 26" type="primary">lysS</name>
        <name evidence="26" type="ORF">AFM11_22460</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="22">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the LPG synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="22"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852733.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08750"/>
    <dbReference type="EnsemblBacteria" id="KWX21933">
        <property type="protein sequence ID" value="KWX21933"/>
        <property type="gene ID" value="AFM11_22460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1842"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 22" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="19" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 22 26" id="KW-0436">Ligase</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="25">
        <location>
            <begin position="790"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1016"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00024681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KWX21933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1104" mass="120984" checksum="7C6E93AB8675A1B9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI80</accession>
    <name>A0A132PI80_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852905.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08235"/>
    <dbReference type="EnsemblBacteria" id="KWX22021">
        <property type="protein sequence ID" value="KWX22021"/>
        <property type="gene ID" value="AFM11_22970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1948"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036435">
        <property type="entry name" value="Leukocidin/porin_MspA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015286">
        <property type="entry name" value="Porin_fam_mycobact-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09203">
        <property type="entry name" value="MspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56959">
        <property type="entry name" value="SSF56959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453277" evidence="2">
        <location>
            <begin position="32"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="215" mass="22488" checksum="F7FAED7AB95F432D" modified="2016-06-08" version="1">MKAISRMLIALTTAMIAAVAGLFASTGTAHAGLDNELSLVDGQDRTLTVQQWDTFLNGVFPLDRNRLTREWFHSGRAKYIVAGPGADEFEGTLELGYQIGFPWSLGVGINFSYTTPNILIDQGNITQPPFGLDSVITPNLFPGVSISADLGNGPGIQEVATFSVDVSGAAGGVAVSNAHGTVTGAAGGVLLRPFARLIASTGDSVTTYGEPWNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIJ6</accession>
    <name>A0A132PIJ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852343.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04285"/>
    <dbReference type="EnsemblBacteria" id="KWX22084">
        <property type="protein sequence ID" value="KWX22084"/>
        <property type="gene ID" value="AFM11_21470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1642"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="418" mass="46516" checksum="3B0DF7B10A66565C" modified="2016-06-08" version="1">MTVASSPQAREYSPFDITSHDFWSQPFAKRDETFAQLRAGEGLSWHQPLSTLFDVDEPGFWALTRRADIQFASQHPEIFTSAQGVALDPMPAEVQKFATFFLMMDPPEHTTYRRLISSAFTPRNVRRIEEQIHANAVAVVDDLIGAGDIDFVEACSARLPMLTISEMLGVPAADQPALAKAAEKLFSMSDDEYSSIEERAMDTINEIMLISNTGVELAKFRRANPGDDLMTSIVNAEVDGHRLTDEEIGAFLILLASAGNDTTKQTTTHAMMALAANPDQRDWLMEDFDGRIGLATEEFVRWATPVIQFARFATQDVELAGQKISAGDKVGLFYCSANRDETVFDNPQRFDLSRSPNPQIGFGGGGPHFCLGNQLAKSELRNLFRELLTRLKTIEFGEPEMLYSSFVHGIKRVPAHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIV6</accession>
    <name>A0A132PIV6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08685"/>
    <dbReference type="EnsemblBacteria" id="KWX21942">
        <property type="protein sequence ID" value="KWX21942"/>
        <property type="gene ID" value="AFM11_22525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1856"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="512" mass="55171" checksum="1E96E48344252EA2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIW4</accession>
    <name>A0A132PIW4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852576.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22204">
        <property type="protein sequence ID" value="KWX22204"/>
        <property type="gene ID" value="AFM11_22190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1787"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453300" evidence="1">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="101" mass="9978" checksum="6A88429F029FC885" modified="2016-06-08" version="1">MKSLTVAAVSGAMAAVGVGLAGVAGAAPTAPTSPTQAVNDLRAQGYNVIVNKVGAAPLEQCVVDGIRPGQTFTRMDSGVAGAGDDIRTTVTAQTVYVDVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ50</accession>
    <name>A0A132PJ50_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851831.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11070"/>
    <dbReference type="EnsemblBacteria" id="KWX22388">
        <property type="protein sequence ID" value="KWX22388"/>
        <property type="gene ID" value="AFM11_19730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1280"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="81" mass="9029" checksum="2E908F9A922AF48F" modified="2016-06-08" version="1">MRRILSRKVSLEQMIETALWLALPYIVIGLLWTFFHPEQVQLIESELLTRIPAGANLVAFGQVTLLWPLLLVGGDICVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJK9</accession>
    <name>A0A132PJK9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851937.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22493">
        <property type="protein sequence ID" value="KWX22493"/>
        <property type="gene ID" value="AFM11_20300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1394"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="204" mass="22710" checksum="AF3B5C59D743FD0A" modified="2016-06-08" version="1">MPLQNRVTPGGAIIATSARGTFMGNRGILHDDNRRIIRTSRNAMWLICELEFKGRRRELMRPGTYTELFFLDEAVALAAGHRPCGECRRRAYRAYIDAANVGNDHPIGSAKELDSQLRASRQEPGTTAEIGTLPDGVFVTFGDNDFRLIWQGTAYRWSPEGYTDPVVLTADRQARVVTPGLSVDALRHGYPVRVHPSAESVTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJR0</accession>
    <name>A0A132PJR0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22543">
        <property type="protein sequence ID" value="KWX22543"/>
        <property type="gene ID" value="AFM11_20530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1443"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="142"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="275" mass="29753" checksum="B2AC93A2D95B1CA5" modified="2016-06-08" version="1">MRWAAREAAMRHEPLSIVHVLPALPVAASALAWPAGRVPEEVLEIQESEGRGFIADATRTARESVGDKELDVAGELFIGAPVQALSELSTDAKMLVVASQGRSKRHRPLLGSVSTGVLYHARCSVAVIHEEAESPQRAHLPVLVGIDGSAVSESAIAIAFDEASWRSVDLLALHVWSDADMPWLPSLETSAQQRVAEETLAERLAGWQEKYPDVTVRRIVRYDRPAQQLLEESGRAQLVVVGNRGRGGFAGMLLGSVSAAVSREARIPVIVARQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKX8</accession>
    <name>A0A132PKX8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850695.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01210"/>
    <dbReference type="EnsemblBacteria" id="KWX22999">
        <property type="protein sequence ID" value="KWX22999"/>
        <property type="gene ID" value="AFM11_16640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.677"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="217" mass="23604" checksum="ADE8BFABEC9E08BB" modified="2016-06-08" version="1">MELYDVMRTTGATRQFTDDPLPDEVLERILDHARFAPSGGNRQGTRIVVVRDRDTRESLADLSVTGARRYIAQKRNGENPWNPLHPMGVTADDLAAVQVPRATQLLDAAVVLVVCVDLGVVAAFDQGLDRIGVVSGASVYPFVWNILLAARNEGYGGVLTTMMVAEEPKVKALLGIPDDFAVAAVLPLGKPVRQLTKLTRKPVSEIATRERFDGPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL55</accession>
    <name>A0A132PL55_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850659.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22984">
        <property type="protein sequence ID" value="KWX22984"/>
        <property type="gene ID" value="AFM11_16540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.657"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="162" mass="18157" checksum="A9694F87CC4F5CB0" modified="2016-06-08" version="1">MSDQVDGILDQWAHEYPQIDASPMGIVGRIWRLSRHLEQQVHAVLAQFDCSLPDFDVLATLRRSGPPYSLTAGQLMESAMVTSGAITNRVDRLIERGLVTREPNAANRRIKQISLTTAGLDLIDKMIPVHVANERRMLAPLTDAEYDNLLAVLRKLLHAYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL62</accession>
    <name>A0A132PL62_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">AFM11_17435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851037.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04955"/>
    <dbReference type="EnsemblBacteria" id="KWX22742">
        <property type="protein sequence ID" value="KWX22742"/>
        <property type="gene ID" value="AFM11_17435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.842"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="108"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX22742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="245" mass="25930" checksum="076C2AE333B282FE" modified="2016-06-08" version="1">MRVGVLGAKGKVGATMVQAVEAAEDLTLSAGVDAGDELTLLTESQTEVVIDFTHPDVVMDNLKFLIDNGIHAVVGTTGFTWERIEQVEAWLKDKPEAAVLIAPNFAIGAVLSMHFAKQAARYFESVEVIELHHPHKADAPSGTAARTAKLIAEARKGLPPNPDATSTGLEGARGADVDGIPVHSVRLAGLVAHQEVLFGTQGETLTIRHDSLDRSSFVPGVLLAVRKVGERPGLTIGIEPLLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLA9</accession>
    <name>A0A132PLA9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17360</name>
        <name evidence="4" type="ORF">AWC31_01940</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850963.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01940"/>
    <dbReference type="EnsemblBacteria" id="KWX23126">
        <property type="protein sequence ID" value="KWX23126"/>
        <property type="gene ID" value="AFM11_17360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13312">
        <property type="protein sequence ID" value="ORX13312"/>
        <property type="gene ID" value="AWC31_01940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.825"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000428">
        <property type="entry name" value="Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00944">
        <property type="entry name" value="CUEXPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX13312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="68" mass="6774" checksum="30F9DEEC01EE4849" modified="2016-06-08" version="1">MSTQTVTVTGMTCGHCASSVREEVGSIPGVTTVDVDLATGLVTIASDTELDEGAIAEAVAEAGYQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLB6</accession>
    <name>A0A132PLB6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850891.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01745"/>
    <dbReference type="EnsemblBacteria" id="KWX23093">
        <property type="protein sequence ID" value="KWX23093"/>
        <property type="gene ID" value="AFM11_17180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.789"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019993">
        <property type="entry name" value="RecB_nuclease_TM0106_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03491">
        <property type="entry name" value="TIGR03491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="2">
        <location>
            <begin position="311"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="1">
        <location>
            <begin position="934"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1136" mass="124108" checksum="222B51F75A0FDE16" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLC1</accession>
    <name>A0A132PLC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_16495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850644.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19825"/>
    <dbReference type="EnsemblBacteria" id="KWX22977">
        <property type="protein sequence ID" value="KWX22977"/>
        <property type="gene ID" value="AFM11_16495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.647"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="171" mass="18702" checksum="1EF0D1DC1DBB7671" modified="2016-06-08" version="1">MTRYATFLRGVNVGGVNLKMAEVAKALEDAGFTDVRTILASGNVLLDSSSPAKKVRSTAEKALRDAFGYEAWVLVYDLKTVAAISAGYPFEREVEGHHSYVTFVSDPDVLDELAGLPAAPDEKIERGDGVLYWQIARNATLGSTIGKTMGKKRYKSSTTTRNLRTLEKVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLP6</accession>
    <name>A0A132PLP6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850352.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15985"/>
    <dbReference type="EnsemblBacteria" id="KWX23275">
        <property type="protein sequence ID" value="KWX23275"/>
        <property type="gene ID" value="AFM11_15780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7280"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="203"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="36244" checksum="2CD10B1CD12175D9" modified="2016-06-08" version="1">MATTESGAKHVGWPSRLTKARLHFVTGKGGTGKSTIAAALALALAAGGRKVLLVEVEERQGIAQLFDVPPLPYEEVKIATAEGGGQVNALAIDIEAAFLEYLDMFYNLGLAGRAMRRIGAIEFATTIAPGLRDVLLTGKIKEIVVRSNKDAKPGKSGRTAYDAVVVDSPPTGRISRFLDVTKAVSDLAKGGPVHSQAEGVVKLLHSEQTAIHLVTLLEALPIQETLEAIDELNELGLPIGSVIVNRNIPAYLAPEDLAKAAEGDVDADAVRAGLAKSGITLSDNDFAGLLTEAIQHATRIAARGESAEVLDTLDVPRLELPALTDGVDLGSLYELAEELAAQGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM09</accession>
    <name>A0A132PM09_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850372.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16425"/>
    <dbReference type="EnsemblBacteria" id="KWX23284">
        <property type="protein sequence ID" value="KWX23284"/>
        <property type="gene ID" value="AFM11_15850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7295"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="3"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="362" mass="39008" checksum="DD9653C18A60AE68" modified="2016-06-08" version="1">MANLFTPLTIRDVTFAHRAWMSPMMQFAAVPDGPDTGTATDWHLAHLGSRATAGAALVMVEATAVDPRGRSSDYDLGLWNDIQAEKLRRITDFVTAQGAVPGIQLVHAGRKGSTGRPWPDASRTENRWDTVGPSPVSFGRLPAPSELTVGEIGSIVGAFADAAARAADAGFRVLELHGAHGYLIHQFLSPHANHRTDAYGGSPANRRRFALEVVRAVRTRWPAELPLFFRVSATDWLGGDTDDPRPGWMVDDTIELAVELKRLGVDLMDVSSGGSAPDAKIPVGPNYQVPFAARVRKEAEIPTAAVGLITEADQADEIVAGEQADAVFLGRVLLRNPAWVWQAAQHLGATLPHPPRYARAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM21</accession>
    <name>A0A132PM21_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16175</name>
        <name evidence="6" type="ORF">AWC31_16780</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850494.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16780"/>
    <dbReference type="EnsemblBacteria" id="KWX23343">
        <property type="protein sequence ID" value="KWX23343"/>
        <property type="gene ID" value="AFM11_16175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18051">
        <property type="protein sequence ID" value="ORX18051"/>
        <property type="gene ID" value="AWC31_16780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7360"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX18051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="366" mass="39105" checksum="D9C30C1E9D27167B" modified="2016-06-08" version="1">MSRSPDPPRRATLASLAAELKVSRTTISNAYNRPDQLSADLRERIFDAAKRLGYPGPDPVARSLRTRKAGAVGLMITEPLNYSFSDPAALDFVAGLAESCEEAGQGLLLVAVGPNRSFEDGSAAVLSAGVDGFVVYSASDDDPYLPVVRQRHLPVVVVDQPKDVPGVSRIGIDDRGGMRKLAEYVLELGHRDIGLLTMRLGRDWPHGSPKPALADPERVLSPHFHVQRERIHGVYDAMVAAGLAPASLTVVESYEHLPTSGGAAAEVALEANPRITALMCTADVLALSAMDYLRSRGIYVPGQMTVTGFDGVPEALRRGLTTVVQSSVEKGRRAGQLLHNPPRSGLPVIDVLDTEVVRGRTSGQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM45</accession>
    <name>A0A132PM45_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inhibition of morphological differentiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15685</name>
        <name evidence="4" type="ORF">AWC31_16080</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850318.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16080"/>
    <dbReference type="EnsemblBacteria" id="KWX23257">
        <property type="protein sequence ID" value="KWX23257"/>
        <property type="gene ID" value="AFM11_15685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17929">
        <property type="protein sequence ID" value="ORX17929"/>
        <property type="gene ID" value="AWC31_16080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7260"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX17929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="289" mass="30933" checksum="30452FCF8C59B8DA" modified="2016-06-08" version="1">MLALVTASDPAAGESIAVQSGQDVGRPVRTAAFFDLDKTVIAKSSTLAFSKPFFDQGLLNRRAVLKSTYAQFLFLMSGADHDQMDRMRSYITNMCTGWDVEQVKSIVGETLHDIVDPLVFAEAAELIADHKLCGRDVVVVSASGEEIVAPIARALGATHAMATRMVVEDGRYTGEIAFYCYGEGKAEAIRALAAREGYSLDHCYAYSDSITDIPMLEAVGHPTAVNPDRALRKEAAARGWPVLTFTKPVSLRDRIPAPSGAAVATTAAVGISALAAGALTYSLLRRFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM48</accession>
    <name>A0A132PM48_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23373">
        <property type="protein sequence ID" value="KWX23373"/>
        <property type="gene ID" value="AFM11_15495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7214"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="270" mass="29690" checksum="527BA27C4F548153" modified="2016-06-08" version="1">MGDAPRIEYAPQLEELGYRTIWVGIGADPVGDMSLLEQMIAATETAIIASAIINMWQDDARSIAHHYHRIVERYGPRLLLGIGLGHPETRDTYDKPYERMIHYVDALLDTEVPAEAIVIGALGTKTLALAGDKTLGAHPYLAVPAHTRYARETLGSSAFLAPEHKVVLNEDDDEARRIGRPYIQHPYLGLRNYTNNLLRHGFTEADIDGSGSDALIDALVAHGSPETIYTHINEHLTAGANHIGIQILTEDPTASPVQAFRTLAERRPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMS9</accession>
    <name>A0A132PMS9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Extradiol dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_16220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the extradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850511.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16825"/>
    <dbReference type="EnsemblBacteria" id="KWX23352">
        <property type="protein sequence ID" value="KWX23352"/>
        <property type="gene ID" value="AFM11_16220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7369"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="142"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="299" mass="33420" checksum="F1C2ABF9775D7130" modified="2016-06-08" version="1">MSIKSLGYLRIEATDVAAWREYGLKVLGMVEGKGQTEGALYLRMDEFPARLVIVPGEHDRLLESGWETANAAELQDIRTRLEANGTPYKEATATELADRRVDEMIVFDDPSGNTLEVFHGVALEHRRVVSPYGHKFVTEEQGLGHVVLTTKDDAETLHFYRDVLGFHLRDSMRLPPQLVGRPADGEPAWLRFLGVNPRHHSLAFMPGQTPSGIVHLMVEVGEADDVGLCLDRALRRKVKMSATLGRHVNDKMLSFYMKTPGGFDIEFGCEGLEVDDNDWVARESTAVSLWGHDFSVGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMV1</accession>
    <name>A0A132PMV1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome C biogenesis protein ResB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_12785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849071.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03105"/>
    <dbReference type="EnsemblBacteria" id="KWX23669">
        <property type="protein sequence ID" value="KWX23669"/>
        <property type="gene ID" value="AFM11_12785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6649"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="38"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="543" mass="60206" checksum="1DA980B7E97458EE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNF9</accession>
    <name>A0A132PNF9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849290.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23879">
        <property type="protein sequence ID" value="KWX23879"/>
        <property type="gene ID" value="AFM11_13240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6741"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="62"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="225" mass="23973" checksum="D33970C2A5FF96FF" modified="2016-06-08" version="1">MADLAKNWAGPIGRFGGAVYDSGVEREWLARPAGLALWGTDTRLLFESIATLGELPDGTAVLDIPCGGGLALRGLRPDQRLRYVAADISPDMLARARVRATALGRSDIEFAEADIEHLPFADGEFDRCLSFNGLHCLPNPAAAVREMARCLKPGGQIVGDAVVRGAGIRQDLLIAAFQRAGAFGPGGTADDLRGWLTDAGLRVERLDRSGAVVHFTATQGDDEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNQ5</accession>
    <name>A0A132PNQ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849645.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29795"/>
    <dbReference type="EnsemblBacteria" id="KWX23904">
        <property type="protein sequence ID" value="KWX23904"/>
        <property type="gene ID" value="AFM11_13910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6878"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="365" mass="39358" checksum="90DA6CF915465F18" modified="2016-06-08" version="1">MNVPLSILDLAPISAGSDAATALRNTVDLAQHAEQWGYKRYWVAEHHFVAVASSSPAVLVGQIAAATERIRVGTAAVQLGHTTAVAVVESFGTLAAFHPGRIDLGVGRSGQRRAEAVREKPKEPKPPREWHEIDGVVIPAPFDIGALLRNPRLRARMAVLQQPEAVAPDFADQVDDIVAMLNGNYEVGTAVPGAGTGLTPWVFGSSKGQSARVAAARGLPFVASYHITPATALEAIEVYRNSFTPSPFLSEPYVVVSADIVVADDEPTARRLAAGYGHWVYSIRAGDGAVPYPDSADLPPLTDEQREMVRDRTATQFVGDPDQVAGRLEALQRVTRADELVVTSVTHRHEDRLRSHELIAKRWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNV6</accession>
    <name>A0A132PNV6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848849.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23983">
        <property type="protein sequence ID" value="KWX23983"/>
        <property type="gene ID" value="AFM11_11475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6371"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041674">
        <property type="entry name" value="TetR_C_22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17928">
        <property type="entry name" value="TetR_C_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="187" mass="21549" checksum="8AFEEDB6F1828469" modified="2016-06-08" version="1">MIRSVLEAAAELLVEVGYEAVLASPALLLDRSRVSRGSFYSFFESPERVLDELAYQGVRQCTASLERAFRNMSGKHWTEVIDVLIELYITEYRVPLIRELWVRQHLTQRARELDDLAISDMAVLMLTEFRSYGPAFDALTELHCRAALHVVERLFQYAFIDRSDGDPSVLGEARRMLIDYFAGFLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP58</accession>
    <name>A0A132PP58_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="4">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-IPM isomerase</fullName>
            <shortName evidence="4">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">leuC</name>
        <name evidence="6" type="ORF">AFM11_11495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848267.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23987">
        <property type="protein sequence ID" value="KWX23987"/>
        <property type="gene ID" value="AFM11_11495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6375"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="5">
        <location>
            <begin position="78"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="416" mass="44181" checksum="E235BC86E8D095FF" modified="2016-06-08" version="1">MAMTMIERILARKAGIPEVHAGDMVTVDVDMTVLIDLQFATMWIQPLKINDPDKVAIVMDHAVPAPTIKDAAGGPKARKFATDFGIHRFYDVGRHGICHQVIAENGLARPGEVLACTDSHTCAGGAYNTAARGLGPAEVYSILCTGSTWFQVSPTIRYEFTGSLPAGVSGKDVFLYLADQYGDAANVNLEYGGPGLASIPLNDRRTIATQGAEVSADFSTFAYDDVLAEHFHELGISGYEPTHADPEAAYSAVRAIDLSRLVPYVARPGTVSRNGKPVNDIEPRKIDQAFIGSCANGQLDDLRIAADVLRGRQVAPGVRLIVTPASQQVYRDAMRLGYLQDIADAGAVVTNATCGACFGYHMGVVGPGEVCLTSSTRNFTGRMGSTEAEIYMASPATVAASAVAGHITDAREAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPC5</accession>
    <name>A0A132PPC5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipoprotein, LppR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_09345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847049.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05880"/>
    <dbReference type="EnsemblBacteria" id="KWX24196">
        <property type="protein sequence ID" value="KWX24196"/>
        <property type="gene ID" value="AFM11_09345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5906"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026954">
        <property type="entry name" value="PknH-like_Extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038232">
        <property type="entry name" value="PknH-like_Extracell_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14032">
        <property type="entry name" value="PknH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PknH_C" evidence="5">
        <location>
            <begin position="42"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="254" mass="26552" checksum="4FE2390D9F088874" modified="2016-06-08" version="1">MTAIGKLGLLMATLVLATGCTRMVDGAVEPAADLAPKPLTGQNVVQALPEIDELTEILEQQLKEDTYVAPRSGGLDDLPDGLATESDASPHDCVGAVTPMQRSTYESAAVTDIAGEQWEGDEPGGAVLAAEAGVVALDSVASANELFDTFAEQWQDCEGTTVTIVKEQVRGGYFTDTVSDVRVEDSIVAATVDFGHTVDGSSSPVARALGVRANCLVEVDVAFFSNPSSRKGGDVETSAIEIARLMMDKISELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPY1</accession>
    <name>A0A132PPY1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847685.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18995"/>
    <dbReference type="EnsemblBacteria" id="KWX24398">
        <property type="protein sequence ID" value="KWX24398"/>
        <property type="gene ID" value="AFM11_10560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6152"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="253"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="389" mass="41229" checksum="8EFC9E1A441FB48B" modified="2016-06-08" version="1">MRRVAVVGAGMTPFAEHFALGIKDLLPVAFSECAATVDKGIDRDDIDAAWFGAMGTTDGFPSGVLADTLGLTDIPVTHIENSCATGNDAVRNALYGIASGAADVALVMGADKLREVATNSMLWGWEAQTRDMAWDYPLGLVAPAGFAMHVRRYLHESPATREHLAMIAVKNHRNAVDNPKARLRFEITVEQALSAPIVVNPFGLYDCAPQSDGAAALVLAAEDVVDRFTDRPVWVRGVGLGLDSVMYPHKPDMTTFPATVRAAKQAFGMAGLTPGDIDVAEVHDYFTGIELMSYEDLGFADRFEAHKLVEAEVTSMGGALPVNTSGGLKAKGHPPGATGVAQCVELFEQLRGEAVNQVDRARIGLAHNIGGPTAVSAVTILEGPHANGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ38</accession>
    <name>A0A132PQ38_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847739.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19180"/>
    <dbReference type="EnsemblBacteria" id="KWX24415">
        <property type="protein sequence ID" value="KWX24415"/>
        <property type="gene ID" value="AFM11_10665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6173"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="163"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="264" mass="26852" checksum="096CF630971F7703" modified="2016-06-08" version="1">MRIGFIGAGRMGTPMVQRLVAAGHDVHAVGRTDDKRTATAELGAHPVSRSVDAGRDADVVIVCVFTDQQVRAICLDDDLVGAMRPGSVIVLHTTGSPRTAEEIARRAAEHDVAVVDAPVSGGPHDIAAGTVTVFMGGSHDAVARARPAVAAYADPVLRVGPIGAGQRVKLVNNTLFAAQIGLVAEGVRLGSELGIDESTLLTALTHGSAGSRALSGIAATGSADAFITRVGEFIGKDVAVVRTTAAELGTDLGLLDATVSAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ51</accession>
    <name>A0A132PQ51_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847827.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19345"/>
    <dbReference type="EnsemblBacteria" id="KWX24443">
        <property type="protein sequence ID" value="KWX24443"/>
        <property type="gene ID" value="AFM11_10830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6205"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="27720" checksum="E0899F5EA24716BD" modified="2016-06-08" version="1">MAINPSDILLTGQVAVVTGGGAGIGRGIAAGLAAFGATVAVWERDVESCASAAEAVDGLGIVTDVRDSEQVDAALARTETELGPVSILVNNAGGVFASPLLETSENGWDALYKSNLRHVLLCTQRVARKLVAAEKPGSVINLTSIEGVRAAPGYASYAAAKAGVINYTQTAAFELAPHNIRVNALAPDLTVTEGLLRLSPAGLPPGIADGIPMGRPGHVDEIAGAAVFLASGMSSYITGQTIHVDGGTRAAGGWYHHPQTGAPTLGPGWGSGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ63</accession>
    <name>A0A132PQ63_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_10985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847900.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24469">
        <property type="protein sequence ID" value="KWX24469"/>
        <property type="gene ID" value="AFM11_10985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6238"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="111"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="313" mass="32967" checksum="AC83F7823199710D" modified="2016-06-08" version="1">MSRVLVTTDYLRPGDEVDVLLRRHGHETIYRPACGPRDPGEARALFDGVRGAIIASEPVTADMFANASDLQVIARSGVGFDSVDLVSATDRGIRVCNTPGVNHGAVAEMTIALMLISARRLTAVIDGVRAGGWPRDAGTELRGTTLAIIGFGPSGRAVANLATAFGMTVLVHTAHPDPTATRVQFVDRDTAFTQADYLSLHTRSDDRTRRMIDASALAAMKPTAVLINTARGSLIDEDALADALDSGQIAGAALDVLDAEPMPAESRLRGRHDVIVTSHLAGQTAEARLRAGLCAAADVIAVLDGREPAHPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQL9</accession>
    <name>A0A132PQL9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_08095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846281.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00030"/>
    <dbReference type="EnsemblBacteria" id="KWX24630">
        <property type="protein sequence ID" value="KWX24630"/>
        <property type="gene ID" value="AFM11_08095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5469"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="3">
        <location>
            <begin position="476"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="751" mass="78633" checksum="09F7958BE8BBB3E0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR64</accession>
    <name>A0A132PR64_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gmd</name>
        <name evidence="6" type="ORF">AFM11_09225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846855.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13145"/>
    <dbReference type="EnsemblBacteria" id="KWX24819">
        <property type="protein sequence ID" value="KWX24819"/>
        <property type="gene ID" value="AFM11_09225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5693"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="8"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="37945" checksum="8FAC0914EEA3F96B" modified="2016-06-08" version="1">MIQAKRAFITGITGQDGSYLAEFLLAKGYEVHGLIRRASTFNTGRLDHIYTDPHVEGTRFFLHYGDLTDGSRLVTLLQQIRPAEVYHLGAQTHVRVSFDEPEYTGDTSALGTTRILEAIRMIGLDCRFYQASSSEMFGASPPPQSEQTPFWPRSPYGVSKVYAYWITRNYRESYGMFAVNGILFNHESPRRGETFVTRKITRAVARIKAGLDTDLYLGNLDAVRDWGYAKEYVEAMWLMLQADEPDDYVVATGSAYSVRDFVEMAFSYAGLDWHEYVKFDERYVRPAEVDCLIGEPSKARELLGWKAKVLTPELVELMVDADYELALAEVRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRQ6</accession>
    <name>A0A132PRQ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_08635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846545.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13735"/>
    <dbReference type="ESTHER" id="9myco-a0a132prq6">
        <property type="family name" value="Abhydrolase_9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24722">
        <property type="protein sequence ID" value="KWX24722"/>
        <property type="gene ID" value="AFM11_08635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5577"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027787">
        <property type="entry name" value="Alpha/beta-hydrolase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027788">
        <property type="entry name" value="Alpha/beta-hydrolase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10081">
        <property type="entry name" value="Abhydrolase_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15420">
        <property type="entry name" value="Abhydrolase_9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_9_N" evidence="4">
        <location>
            <begin position="38"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_9" evidence="3">
        <location>
            <begin position="269"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="575" mass="63819" checksum="9FF2EBC633756E37" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRV7</accession>
    <name>A0A132PRV7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly scaffold protein NifU</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Nitrogen fixation protein NifU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06370</name>
        <name evidence="3" type="ORF">AWC31_29305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845281.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29305"/>
    <dbReference type="EnsemblBacteria" id="KWX25050">
        <property type="protein sequence ID" value="KWX25050"/>
        <property type="gene ID" value="AFM11_06370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13875">
        <property type="protein sequence ID" value="ORX13875"/>
        <property type="gene ID" value="AWC31_29305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4468"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="156" mass="16934" checksum="62BDC5FE7D01B8D9" modified="2016-06-08" version="1">MRMDQMYQEVILDHYKHPHHRGLREPFGAEVYHVNPTCGDEVTLRVALSDDGETVDDVSYDGQGCSISQAATSVLTDQVIGQSVGDALKTVAAFTEMISSRGNVEGDEDVLGDGIAFAGVAKYPARVKCALLGWMAFKDALAQASEETDDERHRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSE8</accession>
    <name>A0A132PSE8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_07385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845762.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17335"/>
    <dbReference type="EnsemblBacteria" id="KWX25225">
        <property type="protein sequence ID" value="KWX25225"/>
        <property type="gene ID" value="AFM11_07385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4677"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="5">
        <location>
            <begin position="18"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="559" mass="64139" checksum="B8DAF8CC54E96529" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSR3</accession>
    <name>A0A132PSR3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor SigK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_03170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21925"/>
    <dbReference type="EnsemblBacteria" id="KWX25304">
        <property type="protein sequence ID" value="KWX25304"/>
        <property type="gene ID" value="AFM11_03170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2508"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="181" mass="20210" checksum="9A4DEAC9135F02C5" modified="2016-06-08" version="1">MTTDLDALLRRVAQRDVDAFAAFYDHTRSRVFGLVTRVLRDPGYSEETTQDIYLQVWNTAGSYNPAAGSPLAWLMTLAHRRAVDRVRSEQAASQRESRYGAANVETPADHVADSVITLDEQRRVSDCLDSLTAAQRECIHLAYYDGLTYSQVSQRLAANLATIKSRMRDAIRGLRNCLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSS2</accession>
    <name>A0A132PSS2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03435</name>
        <name evidence="4" type="ORF">AWC31_21715</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844021.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21715"/>
    <dbReference type="EnsemblBacteria" id="KWX25345">
        <property type="protein sequence ID" value="KWX25345"/>
        <property type="gene ID" value="AFM11_03435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16637">
        <property type="protein sequence ID" value="ORX16637"/>
        <property type="gene ID" value="AWC31_21715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2561"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="87"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX16637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="314" mass="33016" checksum="3CA81556E216A9B4" modified="2016-06-08" version="1">MTFLFPAALMLLVPVALLAVGYLVTLRRKQRYAVRYAALPLLDKVIPERPQWRRHVPAALLLITLGLLALTAARPEMAVRVPYERATIIVAIDTSESMQARDVEPDRLTAAIAAAGDFIDQLPPAFNVGVIAFAGSTVVVHAPDTDHAGAKDSLRSIGTSSRTAIGEGVFAALAQIRTVTGDEGTDLPAHVVLLSDGTNTSGRSPTAAARAAVAAGVPVSTIAYGTEGGVMESYGYSTPVPVDAETLAELADTTGGTAYAAASSDELADVYRDISSSIGWRTEWREVTPFVAALALVFGLVAAGLSLRWFSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSY2</accession>
    <name>A0A132PSY2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845490.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28745"/>
    <dbReference type="REBASE" id="146316">
        <property type="entry name" value="M.MwoCDC01ORF6905P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25142">
        <property type="protein sequence ID" value="KWX25142"/>
        <property type="gene ID" value="AFM11_06905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4580"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="555" mass="60002" checksum="EE63AD2EA1C8A366" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT09</accession>
    <name>A0A132PT09_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="2">2.6.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844325.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21135"/>
    <dbReference type="EnsemblBacteria" id="KWX25435">
        <property type="protein sequence ID" value="KWX25435"/>
        <property type="gene ID" value="AFM11_04020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2682"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005802">
        <property type="entry name" value="ADC_synth_comp_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00553">
        <property type="entry name" value="pabB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="146"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="416" mass="43041" checksum="2E5741615A83675C" modified="2016-06-08" version="1">MRIERLGDLGEAPAVLRSVAAAAAAAHLPPPAALIGDWFGSRAVIAPSLAAAPVGPAEVFDAPPGTADVIGGGWFGYLSYPDPGADESTPRIPEAAGGWSDCVLRQDGGGSWWYESLTGAALPDWLGHLPPAPPAPYTLEWIAPDRARHRDGVLACLEAIAAGEVYQACVCTRFTGRIEGPPLEFFAGAVTRTAPARAAYIAGDWGAVASLSPELFLSRRGTSVTSSPIKGTLPKDADPAGLLASVKDVAENIMIVDLVRNDLGRVARTGSVTVPELLAVRPAPGVWHLVSTVSAQVDAAVTMSALLDATFPPASVTGTPKGRARELLRVWEPTRRGVYCGTVGLASPVAGCELNVAIRTVEFDATGAAVLGVGGGITADSDPDREWDECLHKASSLVARTRGGKPAQPRARSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT27</accession>
    <name>A0A132PT27_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cutinase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_04415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844488.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20730"/>
    <dbReference type="EnsemblBacteria" id="KWX25496">
        <property type="protein sequence ID" value="KWX25496"/>
        <property type="gene ID" value="AFM11_04415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2759"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007356436" description="Cutinase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="209" mass="21281" checksum="FB6E4E30FB1D0669" modified="2016-06-08" version="1">MTIKPAWILAFAALAAVAPTVTPAPASAAPCADVEVVFARGTNEPPGLGSVGGPFVEDLRARVAPRTVDAAAVEYPASNDFNVSTPAGVDAARSLIESIAADCPNTKIVLGGYSQGAAVIELATNEASPRVADRVAATALFGTPRTGFANMLAGRALPTLAPRFAGNSIDQCNQGDPICWEGGWDMGAHVSYVQSGKVAQAADFTAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT69</accession>
    <name>A0A132PT69_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844536.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20615"/>
    <dbReference type="EnsemblBacteria" id="KWX25513">
        <property type="protein sequence ID" value="KWX25513"/>
        <property type="gene ID" value="AFM11_04530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2785"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="475" mass="51669" checksum="BAC42B1A8C1B4138" modified="2016-06-08" version="1">MPYQDFREFLDALRARGELIDVDRPVALELEVAKAMRKSAAVAGPAIVFTNNGSEFPLVGGVYNSRAKALIAYGCDEDTVVEHILHGLAQRIPPVVIEHAPVHENVVLGDDVDLATLPVPRYSPDDGGPYITAGIVVSRDPDSGTPDIGHYRFEIIDKHTMSFLAMPNHRFGKNLAKAAARGQKSFRAALVIGVDPMLAYTGPIQVPEDTNDFEVAGGLRGAPVELVKCRAIDLEVPAHAEFVIEFEVDFDHTVFEGPLGEYTGYYTPGSMKPIARPLALTYRDKPYFQALLTGKPTTENHVLKQLAFEASFLDSMRKTFPTIERVAIPPSGGVNFRVVMAMRPRFAGEARNAILTAMGSNVRPKTVIVVDPDIDVQNSGEVEWALAFRTQPARDVIIVDDLPGGPLDPTLDDTLPPDRRTGSALGIDATYPYGTAVKVAGEACGPAQAEHGREFVEVADVPGWRDYAFPELDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT76</accession>
    <name>A0A132PT76_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20570"/>
    <dbReference type="EnsemblBacteria" id="KWX25520">
        <property type="protein sequence ID" value="KWX25520"/>
        <property type="gene ID" value="AFM11_04575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2794"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="466" mass="49493" checksum="BC6AF36997160422" modified="2016-06-08" version="1">MPSPHGPGLGASDMNLTSGWLPITLQILTLVVLVAAIGWRTPQWRTRWVPIAIGAGVAFAVIVRLFVKFQGWSDRAASTATVVWVAITGVAIAIAVLGWRDAAWWRRSLSILAVPLSVVCAAAALNTATGYFPTVQSAWQRLTGTESPQWIDEETLAAMRRDGERPTRGTIVKITTPDNVSGFKHRQELVYLPPAWFASDPPPQLPAVMALGGEFSHPEDWPESGGALKTLDEFTARHHGNAPVMVFPDSTGSFSNDTECVNGPRGNAADHLTKEVVPYVVSKFGVSTDPANWGLVGWSSGGTCALTLAVTHPELFSAFVDLDGQLGPNTGTKQQTIARLYGGDAEAWAAFDPQTVILEHGQFPGMAAWLGVSDDTPTVYRPAGDRPPAPEEIADWDPYSEEHAENAKKLCALLSGHGVECSVSSYSGSHDFPSAGEGFAAALPWLAGKLGTPGVPVTPMPGASEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTA8</accession>
    <name>A0A132PTA8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844330.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21125"/>
    <dbReference type="EnsemblBacteria" id="KWX25437">
        <property type="protein sequence ID" value="KWX25437"/>
        <property type="gene ID" value="AFM11_04030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2684"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="394" mass="41340" checksum="99A823F0ED9C4BA8" modified="2016-06-08" version="1">MTNQTPHVVVIGGGYAGVLAANHLQSNPRVAITLVNPRPTFTERIRLHQMAAGNYDAAADYAELLGDRVRLVVDGAERIDADIRQVQLTSGDVLDYDYLIYAVGSTGGVPASVPGAAEFAYPLSEFEQAQRLRARLQDVPMSAPLVVVGGGLTGIEAASEFAEAGRNVTLVTDVVGASLGVQARRSVVKALTKLGVTIVDGPDILVASVSATEVFMADGNRLPSAVTVWTTGFGVPGLAAASGLTTDGLGRLLTDEALTSVDDARIVAAGDAASPSGVPLRMSCQAAGPMGVQAANTVLARIAGEKPAELNQAFSGQCISVGRTFGTVQISHSDDTPRRIYIGGRTAAFVKEQVCRATLTFMRKEARKPGSYFWFKGGDRERQIAEARKEAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTK6</accession>
    <name>A0A132PTK6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03660</name>
        <name evidence="3" type="ORF">AWC31_21495</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844129.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21495"/>
    <dbReference type="EnsemblBacteria" id="KWX25382">
        <property type="protein sequence ID" value="KWX25382"/>
        <property type="gene ID" value="AFM11_03660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16597">
        <property type="protein sequence ID" value="ORX16597"/>
        <property type="gene ID" value="AWC31_21495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2607"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019674">
        <property type="entry name" value="Lipoprotein_LpqN/LpqT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10738">
        <property type="entry name" value="Lpp-LpqN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453584" evidence="1">
        <location>
            <begin position="31"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="216" mass="22831" checksum="2A956DE6C7751405" modified="2016-06-08" version="1">MKATTRTAAILAMLTLVTASCTRVVEDAQAVPGQDLLEAAATDNPDCEEVDAQLATVDSRNPDEPVLKVPQPDGWERTTMMDSELIRFAMANPALGTPEFAPTAVVTLESGPGNEDPEVVFSSQRDALESGLGATDISVESHTLCGLPAETIHYQMPPMGLVAPHPAMVTAAVLHTDDMTFVAAVTVQTTDPANPAYQRDAETILSGFQMLPPTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTM6</accession>
    <name>A0A132PTM6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844888.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21150"/>
    <dbReference type="EnsemblBacteria" id="KWX25686">
        <property type="protein sequence ID" value="KWX25686"/>
        <property type="gene ID" value="AFM11_04005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2679"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="277" mass="30395" checksum="75AD268FB022C010" modified="2016-06-08" version="1">MWPIIGTEAIAAGVLTRGELRWNHTALLPNIYLPKGVRPSVSTNAAAAWLWRGRKGVVAGRSAAALYGVSWIEETVPIELIGRHGRRQPGVTIRDERIGEDEICQVANLPVTTPARTALDLARRLPRDDAVAHLDALASKTGVTVQEVLSLAERYPHTRGIRQARESVALMDGGAETPRQTWLRLLLIDAGMPKPQTAIALADSDWETTVAIGWRGPKVGIDIAEDPVSDPYSIVQKIARAELRQRLGWFDIRVAPAHTTASIIYRVRQALRQRGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTV0</accession>
    <name>A0A132PTV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20910"/>
    <dbReference type="EnsemblBacteria" id="KWX25694">
        <property type="protein sequence ID" value="KWX25694"/>
        <property type="gene ID" value="AFM11_04245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2726"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="98" mass="10105" checksum="542DC1095285FD64" modified="2016-06-08" version="1">MGMVFIGPILYATINLILGFMAFFAAGSYDSQGGNPNIVLAAAAVVLAVIAFGGGIVLLRQSSRYAKGLGIGLMIGWALVSLFTAGFCTGVNPQLYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTX3</accession>
    <name>A0A132PTX3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsS</name>
        <name evidence="7" type="ORF">AFM11_00265</name>
        <name evidence="8" type="ORF">AWC31_33375</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003892827.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A132PTX3"/>
    <dbReference type="STRING" id="59750.AWC31_33375"/>
    <dbReference type="EnsemblBacteria" id="KWX25770">
        <property type="protein sequence ID" value="KWX25770"/>
        <property type="gene ID" value="AFM11_00265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11581">
        <property type="protein sequence ID" value="ORX11581"/>
        <property type="gene ID" value="AWC31_33375"/>
    </dbReference>
    <dbReference type="GeneID" id="66732899"/>
    <dbReference type="PATRIC" id="fig|59750.3.peg.54"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX11581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="93" mass="10774" checksum="272D7E4C448AF76E" modified="2016-06-08" version="1">MPRSLKKGPFVDDHLLKKVDVQNEKNTKQVIKTWSRRSTIIPDFIGHTFAVHDGRKHVPVFVTEAMVGHKLGEFAPTRTFKGHIKDDRKSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUE8</accession>
    <name>A0A132PUE8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ORF">AFM11_00430</name>
        <name evidence="7" type="ORF">AWC31_33545</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014814254.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33545"/>
    <dbReference type="EnsemblBacteria" id="KWX25797">
        <property type="protein sequence ID" value="KWX25797"/>
        <property type="gene ID" value="AFM11_00430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11611">
        <property type="protein sequence ID" value="ORX11611"/>
        <property type="gene ID" value="AWC31_33545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.87"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX11611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="122" mass="13405" checksum="A6530E5022AE3A1F" modified="2016-06-08" version="1">MIQQESRLKVADNTGAKEILCIRVLGGSSRRYAGIGDVIVATVKDAIPGGNVKRGDVVKAVVVRTVKERRRADGSYIKFDENAAVIIKNDNDPRGTRIFGPVGRELREKRFMKIVSLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUH6</accession>
    <name>A0A132PUH6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_01595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842840.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25986">
        <property type="protein sequence ID" value="KWX25986"/>
        <property type="gene ID" value="AFM11_01595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.327"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="176" mass="18591" checksum="2BB99E2E419CCE6E" modified="2016-06-08" version="1">MTTARVLIAYDGSADARTAIAEVARLLPGVKAVVLYARQPLEGLAAHLEGHRALEDLRGVEKASLDASERIAFEGAERARAAGLSAEPRVLSRMSTASEAIVQAAEEIDAALIVLGSRGRRGLWSAVLGSTSVNVLHHARRPTMVVPSEAVASARQRSSKPASEPVAPETPRPEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUJ5</accession>
    <name>A0A132PUJ5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF732 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_01590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25985">
        <property type="protein sequence ID" value="KWX25985"/>
        <property type="gene ID" value="AFM11_01590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.326"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453352" description="DUF732 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="2">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="108" mass="11857" checksum="0D319CD196518A61" modified="2016-06-08" version="1">MLKKTWAAVLLAGMAALTFAAPAQADPDSDFARELHVYGIYGQKDFNAWIGKIACKRLDRGVDVHAADSAKFVADQLPRGSSSEQAYQFLGAAMNYYCPDKRVLLTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUU1</accession>
    <name>A0A132PUU1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843031.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34780"/>
    <dbReference type="EnsemblBacteria" id="KWX26044">
        <property type="protein sequence ID" value="KWX26044"/>
        <property type="gene ID" value="AFM11_02000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.409"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="132" mass="13896" checksum="EDACC44FAEC0666C" modified="2016-06-08" version="1">MTIEIDWNVLRRKAIEVSSSAYAPYSGFPVGAAALVDNSRIVTGCNVENVSYGLGLCAECAVVCALHSGGGGRLLALTCVGPDGGLLMPCGRCRQVLLEHGGPELLIDHPKGPRPLRELLPDAFGPDDLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUV5</accession>
    <name>A0A132PUV5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_02335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843213.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35115"/>
    <dbReference type="EnsemblBacteria" id="KWX26100">
        <property type="protein sequence ID" value="KWX26100"/>
        <property type="gene ID" value="AFM11_02335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.479"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="PTHR14463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX26100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="485" mass="55289" checksum="48028FD346C7E243" modified="2016-06-08" version="1">MEWFTAPEYWFARQVLQRGTAAIYLVAFIAAARQFRALMGERGLLPIPAFLARTSFRRAPSIFHLHYSDRFFAVVCWTGAAISAALLAGAGDLLPLWAAMLAWLLLWVLYLSIVNVGQTWYSFGWESLLLEAGFLAIFLGNDDIAPPVLVLWLTRWLLFRVEFGAGLIKLRGDRCWRDLTCLYYHHETQPMPGPLSWFFHHLPRPLHRIEVAGNHFAQLVVPFALFAPQPIASGAAAIVIVTQLWLVLSGNFAWLNWVTIVLAASAISDSAAATVLPVAAPELSDTPLWFVVAVVAVTAVTVVLSFWPVRNLVSKRQRMNASYNNYHLVNSYGAFGAVGRSRDEVVIEGTDDDVVTASTTWREYEFKGKPGDVRRRPRQFAPYHLRLDWLMWFAAISPAYAQQWLRTLLVRLLENDRQTLKLLRHNPFPDHPPRYVRARLYRYRFSTWDELRHDHVWWERTLLTDYLPPVALRGSAQGARPARPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUY3</accession>
    <name>A0A132PUY3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843303.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35295"/>
    <dbReference type="EnsemblBacteria" id="KWX26130">
        <property type="protein sequence ID" value="KWX26130"/>
        <property type="gene ID" value="AFM11_02515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.515"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="359" mass="38954" checksum="3E189939A411BD53" modified="2016-06-08" version="1">MPGSTRPQRHVGLVTDPGLSTKVVESLTAALPAMLAGSVRDDVCWKVTVHSYAMPLEDDGNIEIRKHSDELKSRYGWDFVVCVTELTRRLGETLVVCEANIAEGTALISLPALGPVRLRRHVAGAIVHVVGALTTAGAEDRNRATVGPLFEPTKREVTDGGKNSYLELTRVHGRLRLLLGMVRVNRPWRLLPSLSSAIAAGVAAAAFGVFYSSIWNMADSMSTTRLAAVSVVAILAMMLWLMLYNGLWERPRDLDQRQNAVLYNGATVLTLGVGVASMYVMLFCVVLMGALTIVPPSYLAATLEHPVTWRDYAELAWLASSLGTFAGALGSSFESDYTVRNATYGKREQERHARAAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV41</accession>
    <name>A0A132PV41_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_02585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GmhB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35360"/>
    <dbReference type="EnsemblBacteria" id="KWX26144">
        <property type="protein sequence ID" value="KWX26144"/>
        <property type="gene ID" value="AFM11_02585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.530"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="6">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX26144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="496" mass="53370" checksum="5E7D07DCD44656D5" modified="2016-06-08" version="1">MSGPVNFAIVVPTIGRKTLQRLLAALEKSDGPTPEAVIVVDDRPEPDPPLLITANLPVTVLRSGGRGPAAARNVGWRSSTARWICFVDDDVRPHPGWLTALAEDLKAAEAAGAVGSQAVIDVPVRPGRRSTDDERRTQRLATAQWITADMAYRRSALVEVGGFDERFPRAYREDSDLALRITMAGNRIIQGARRSRHPVARATWLSSIRAQRGNRDDALMHRKYGRGWRPAIGEGRGRLPAHLATTAAALFAVAGRGRPAARWAALGWLALTVEFAVRRFLAGPRTVTEAARMLITSILIPPVAVYHRLRGEWDFRGAHRDPPLAVLLDRDDTIIEDGPYLNDPDGVRPVAGAVEALNKLRERGLMLAVVSNQSGIAKGLISTSQLADVNARVDALLGPFDSWQICVHDAGDNCSCRKPAPGMVMAAAEALGVQPSRCVLIGDTGGDVQAALSAAADAVLVPTDRTLPQEISDARARARVASTLEDAVSLVLRDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVB4</accession>
    <name>A0A132PVB4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26255">
        <property type="protein sequence ID" value="KWX26255"/>
        <property type="gene ID" value="AFM11_01640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.338"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="238" mass="24867" checksum="1B9A1DB01651AE3F" modified="2016-06-08" version="1">MLRAQAERLRVTPLSEQCRTLNFDVAYQIQDEALSQRIERGENIVGVKVISGTPVAPLTGWLTDAMALRAGEPLPRESLVHPAVRPAVAFVMGRRLGGPGVTAAAALAAVDLVFASLEVTDSRYADRACTLPDLVADNLSSSFYLTGPVGFAPAGLDLSQEEAGITVAAGKATAMRFDAVTRTHPAEALAAAANCLARRGHAIESGWTVLVGSTPLPLAVGFPVTARFSSLGTVTLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVP3</accession>
    <name>A0A132PVP3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843218.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35125"/>
    <dbReference type="EnsemblBacteria" id="KWX26102">
        <property type="protein sequence ID" value="KWX26102"/>
        <property type="gene ID" value="AFM11_02345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.481"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="277" mass="28488" checksum="507CB74A166C62A1" modified="2016-06-08" version="1">MQIRSAGGGAAQVLRPDVHRGTVAVITGGGTGIGRAVALDLAACGADVVICGRREEPLEKTAVDIEALGARALVVPADIRDDAAVTALVDRALGEFGRIDTLVNNAGGQFAAPAEEITSKGWRAVHRLAVDATWAVTREVAVRAMIPQRSGAIFFMAFSPRRGIASMVHATSARAALENLAAGLSLEWSRFGIRSVCIAPGTIATEGMEENYTEAARAEWAAAVPLGRLGTAEEVSGVIAFLASPGGSYVTGTTIVIDGGADAWGAGHPAPRPEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAW2</accession>
    <name>A0A132PAW2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_35635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000046">
        <property type="protein sequence ID" value="KWX19471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859877.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19471">
        <property type="protein sequence ID" value="KWX19471"/>
        <property type="gene ID" value="AFM11_35635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5862"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="199" mass="21970" checksum="EA83DC2A575AB04D" modified="2016-06-08" version="1">MTTDDAAHEQSGGTSRRDVLLQVAADLFLRNSYDGVTVDMICTAAGISGPGLYNHFENKQALLIAVVESPLAALHQFARETAESEPDPRAALEILVDFHIRSVIGAAPTTLIFMKNEHALPEKDRRRIRREMNLYAEEWISIVSILRPDLSEPEVRLLTQAVFSMLNVVATLNKGLDQESIVKTMSTAAIKALTSPRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBI3</accession>
    <name>A0A132PBI3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859430.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19691">
        <property type="protein sequence ID" value="KWX19691"/>
        <property type="gene ID" value="AFM11_34540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5253"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="93" mass="9622" checksum="9D24F9A24153EDD5" modified="2016-06-08" version="1">MMAATMLSGCSADPGRPAASDDPVTTLPVPANMPPFPYPNDIPPVPLPSAVPDVELPGEIPRAQLPADVPQIEMPAAIPQIQLPSAIPPIPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBM1</accession>
    <name>A0A132PBM1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19720">
        <property type="protein sequence ID" value="KWX19720"/>
        <property type="gene ID" value="AFM11_34320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5206"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="112" mass="12080" checksum="5F1C4ED4BDACDCA4" modified="2016-06-08" version="1">MDGRPELTTWGTAILFGSTTAELGRWVDLDGDPAAAEKLPAWLIQQGRRRTREAQAAVGAGSVTAVLTHWAVRDFGSGVVAFDMVVSANMHQLWMITTPEAAQRITGETEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBQ4</accession>
    <name>A0A132PBQ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_33975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859000.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02425"/>
    <dbReference type="EnsemblBacteria" id="KWX19763">
        <property type="protein sequence ID" value="KWX19763"/>
        <property type="gene ID" value="AFM11_33975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5132"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="132"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="531" mass="55824" checksum="28B5D5F8871FCE9E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBU7</accession>
    <name>A0A132PBU7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GDP-mannose-dependent alpha-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_34100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859074.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02550"/>
    <dbReference type="EnsemblBacteria" id="KWX19786">
        <property type="protein sequence ID" value="KWX19786"/>
        <property type="gene ID" value="AFM11_34100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5157"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="14"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="199"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="375" mass="40543" checksum="A85B8881E0AE9433" modified="2016-06-08" version="1">MRVAIVAESFLPNVNGVTNSVLRVIEHLRRTGHEVLVIAPDTPRGQPPADRVHDGVRVHRVPSRMFPKVTSLPLGVPRPRMVSVLRGFDPDVVHLASPALLGWGGVHAARYLGVPTVAVFQTDVAGFAESYGIGMLSRASWAWTRRLHSKADRTLAPSTSAMENLAAHRIPRVYKWGRGVDITGFAPSARDQDLRAAWSPDGRPIVGFVGRLAPEKHVERLAALAGRDDLQLVVVGDGVDREKLGSVLPSAVFTGELRGEALAAAYASMDVFVHPGEHETFCQAVQEAMASGLPVIAPDAGGPRDLVSPYRTGLLLPVAEFETVLPAAVEHLIAERSRYSVAARRSVLGRTWPAICDELIGHYEAVQGQRRLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBW1</accession>
    <name>A0A132PBW1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858825.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08090"/>
    <dbReference type="EnsemblBacteria" id="KWX19808">
        <property type="protein sequence ID" value="KWX19808"/>
        <property type="gene ID" value="AFM11_33665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5069"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453130" evidence="1">
        <location>
            <begin position="40"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="VanY" evidence="2">
        <location>
            <begin position="88"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="214" mass="22582" checksum="3CFE1C5C19FB3EA5" modified="2016-06-08" version="1">MTVNSYRSVQLVLLAVSVLLATALLGVLVHESVVSPSSAAGAEILVKHHDLLGPPSAAPSRSRVGVADGVVADRVTVFDETSPAVVNLDPDLLGALRLAATQAADEGVVFVVNSGWRSAAYQEQLLREAIAQYGSADEAARWVATPATSAHVSGDAVDIGPAEAASWLSTRGAEYGLCQIYTNEPWHFELRPDATNHGCPLLYADPTEDPRMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC29</accession>
    <name>A0A132PC29_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859718.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19542">
        <property type="protein sequence ID" value="KWX19542"/>
        <property type="gene ID" value="AFM11_35215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5773"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="74" mass="8199" checksum="729FAB406779FCF1" modified="2016-06-08" version="1">MDEKRVVALQVRVDAGRAERFAALARAMNVTSSELLRQAIDELLVKAENHVGALSDRIQHQVSTERDGLRDGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC40</accession>
    <name>A0A132PC40_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859745.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19552">
        <property type="protein sequence ID" value="KWX19552"/>
        <property type="gene ID" value="AFM11_35270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5784"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="253" mass="28310" checksum="0FCA0BC26C19BB84" modified="2016-06-08" version="1">MTAPEFAYSAAWRAELERWHAELANTINQASLWAREFHVRTGDSRWGDASAPPSHPLLGYAERLEKISATLKMVCANASLNPPIPRWDRTTLKAPPRIQIPGHDPDWRDADYTEGGRYLLFIRPSAPNSDIVTAQQHWRAALALSAPSVLESHLGIPQLATYAEQAQGLFDIAHDTIRAAFRDSVAATFGRLWATWPTPEDSTRPLIMWMSELTQYGCSTEECEAVLRDIEAIDPEAVARCREAGAWWRPHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCA4</accession>
    <name>A0A132PCA4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858496.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17120"/>
    <dbReference type="EnsemblBacteria" id="KWX19934">
        <property type="protein sequence ID" value="KWX19934"/>
        <property type="gene ID" value="AFM11_33105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4953"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="361" mass="36186" checksum="20AA54E1BDE9A1D8" modified="2016-06-08" version="1">MGIMPDSSPFGSQTVTGPAWPNVDEEQLTAAAASYEKLAANISGNIVPEQTSQLMKLTEVWQGAGSLAASGEATTMIAGHEANAAQAQAIATQLTQMAAAVVQTKMAVNAAAQEVQHEVEALQALPFGNKQELIESRIKMGLSQNIATVTASTTSLASSLGTVANVPQMTTPPTAQAQQGMQQGMQQAMQMAGQLPQMLGQIPQMLGQIPQQLSQPLQQLSQPLQQLTSMLGSVGKGGGTGGGPSPFSAFSNHPLAGGSGPSSGAGMMKAASLPGTGGVGSQTPLMSKLVGGNTTPVSVDPATAGSTAIGLAPVAAGGMGGMGAPMGMMGQRGASGGTSATLAVPAPLEHEVDVDDDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCH6</accession>
    <name>A0A132PCH6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858376.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32400"/>
    <dbReference type="EnsemblBacteria" id="KWX20016">
        <property type="protein sequence ID" value="KWX20016"/>
        <property type="gene ID" value="AFM11_32955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4921"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="209" mass="23220" checksum="00289ABAB689EDEE" modified="2016-06-08" version="1">MTVSPREQLPTARGRQTQAAIDAAARAVIARKGILAATIADIAAEAGRSTASFYNYYDSKEAMVREWALRFRDEARDRARAVGQPGLTNWERSYQAVSAHWTTYRHRLAEIISVSQLAMVNDDFAHYWAEICELPISLITGMVEHAQRQGFCPGDVPRLTAEALVSMLNQFCFVKLSGGNADDVDDEACIMALANVFYRTIYHEGTARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCQ8</accession>
    <name>A0A132PCQ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_32640</name>
        <name evidence="11" type="ORF">AWC31_19775</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX17110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858237.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19775"/>
    <dbReference type="EnsemblBacteria" id="KWX20125">
        <property type="protein sequence ID" value="KWX20125"/>
        <property type="gene ID" value="AFM11_32640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17110">
        <property type="protein sequence ID" value="ORX17110"/>
        <property type="gene ID" value="AWC31_19775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4856"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="9">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX20125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX17110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="128" mass="13403" checksum="6361EB2C8AD87016" modified="2016-06-08" version="1">MTSSFDLRSIPGWFRLIGLAEAVSWAGLLVGMYFKYLGTPRTEIGVKIFGPIHGGVFIAFVVAALLVGIAHKWGIGTWILALLASIVPLGSVIFIIWADRTARMGSSSGSAGAASLTAQPGRAAPETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCV7</accession>
    <name>A0A132PCV7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_32050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857864.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20175">
        <property type="protein sequence ID" value="KWX20175"/>
        <property type="gene ID" value="AFM11_32050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4736"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="15"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="460" mass="49518" checksum="44FB3D53E902B9BA" modified="2016-06-08" version="1">MANATKRPDTSISRVAAASLVGTTIEFFDFFIFGTAAALVFSKLFFPDLSPLIGTLSSFATFGVAFAARPLGALIFGHFGDRIGRKHMLVISLLMMGVGTVAVGLLPTYEQVGILAPILLVVCRLLQGLALGGEWGGAVLMAVEHAPKGKRAFYGSWPQVGVPFGLVLATAMFFLVQLLPEDAMMSWGWRIPFIFSAVLVLTGLYIRLKLEDSPAFRSLKENRQEERFPAGVVFRRAWKGVVLGALSIAAANIPFYMATVFALTYGVGDGIGRNTVLGAVCVASVLQMATIPMAGMLCDRFGRRPLLMVGAAATIALGFPFFWLIDTHNTAAIFLALVLALPICHTLTYAPMASFLPEIFPTQLRYSGAGIAYTIGGLMFSAPVPFVATALFGTFEAAWPLSVYIMIGGVLTLFAVWVSRETVNDDIDWVTRPNVKDGLRTNDSPQDEITGEPVPTVRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD61</accession>
    <name>A0A132PD61_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allophanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857560.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26120"/>
    <dbReference type="EnsemblBacteria" id="KWX20269">
        <property type="protein sequence ID" value="KWX20269"/>
        <property type="gene ID" value="AFM11_31540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4213"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014085">
        <property type="entry name" value="Allophanate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02713">
        <property type="entry name" value="allophanate_hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="552" mass="57075" checksum="FD0CDCB4B556631D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD77</accession>
    <name>A0A132PD77_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urea carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857551.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26105"/>
    <dbReference type="EnsemblBacteria" id="KWX20266">
        <property type="protein sequence ID" value="KWX20266"/>
        <property type="gene ID" value="AFM11_31525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4210"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017792">
        <property type="entry name" value="Urea_carboxylase-assoc_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03425">
        <property type="entry name" value="urea_degr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="2">
        <location>
            <begin position="52"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="29365" checksum="D838D653CF5A74B6" modified="2016-06-08" version="1">MSTTTETSTTAGAREHARAQATAITDSMPVVPASSWPSPPDGIAAEKLTWAETVPGGRYTTKVLARGTRLRLRDLHGTACAHLLLWRADAPWERLNVADTVKVPWQAYLSSGHPLLSDQGRVLATIVSDTSGHHDAVCGTTTLSGNNAKYGAGSPESASPAGRELLALAALKNGLTRRDVAPSVSFFHGVRVQPDGALVSTGSAGAGTAVELLLHLPLIVAIANTAHPLDPAPTFDVGSLEVLAWSAPDDLAEIGARLTDRDPEYQRAFLNSEDVWSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD79</accession>
    <name>A0A132PD79_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_32060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857871.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31835"/>
    <dbReference type="EnsemblBacteria" id="KWX20177">
        <property type="protein sequence ID" value="KWX20177"/>
        <property type="gene ID" value="AFM11_32060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4738"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="253"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="403" mass="44070" checksum="5601A5348B83972F" modified="2016-06-08" version="1">MTFSLQLSDDVIEVRDWVHRFAADVVRPAAAEWDEREETPWPVIQEAAKVGLYSPELFAQQAAEPSGLGMLTVFEELFWGDAGIALSILGTGLAAAALAGNGTPEQLGRWLPEMFGTADEPKLGAFCSSEPDAGSDVGAIRTRARWDEATREWVLNGTKTWATNGGIANVHIVVASVYPELGSRGQATFIIPPGTHSLVQGQKFKKHGIRASHTAEVVLDNVRLSEDLILGGREKFEERIARVKSGSSARGQAAMKTFERTRPSVGAMAVGVARAAYEYALDYACQREQFGRKIGEFQAVAFKLADMKSRIDAARLLVWRAGWMARNNQNFDSAEGSMAKLVASETAVYVTDEAIQILGGNGYTRDYPVERMHRDAKIFTIFEGTSEIQRLVISRALTGLSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDD8</accession>
    <name>A0A132PDD8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyruvate dehydrogenase [ubiquinone]</fullName>
            <ecNumber evidence="2">1.2.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Pyruvate oxidase</fullName>
            <shortName evidence="2">POX</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pyruvate:ubiquinone-8 oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">poxB</name>
        <name evidence="7" type="ORF">AFM11_30855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A peripheral cell membrane enzyme that catalyzes the oxidative decarboxylation of pyruvate to form acetate and CO(2). It channels electrons from the cytoplasm to the respiratory chain at the cell membrane via ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2</text>
            <dbReference type="Rhea" id="RHEA:27405"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="1.2.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="2">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The C-terminus inhibits activity; it has to move for the enzyme to be active. Activated by lipid-binding, which occurs via the C-terminus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">Has 4 domains; the Pyr domain which binds the pyrimidine moiety of the thiamine pyrophosphate cofactor, the FAD-binding domain, the PP-binding domain which binds the pyrophosphate portion of thiamine pyrophosphate and the C-terminal membrane binding region. The C-terminus is held closely against the rest of the protein and covers the active site; during activation it unfolds from the rest of the protein and forms an amphipathic helix upon membrane binding, exposing the active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.5.1" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857158.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26575"/>
    <dbReference type="EnsemblBacteria" id="KWX20353">
        <property type="protein sequence ID" value="KWX20353"/>
        <property type="gene ID" value="AFM11_30855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4073"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052737">
        <property type="term" value="F:pyruvate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042867">
        <property type="term" value="P:pyruvate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00850">
        <property type="entry name" value="POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044261">
        <property type="entry name" value="PoxB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="192"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="381"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="FAD-binding domain" evidence="2">
        <location>
            <begin position="183"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="2">
        <location>
            <begin position="408"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="2">
        <location>
            <begin position="435"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="2">
        <location>
            <begin position="462"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Membrane-binding domain" evidence="2">
        <location>
            <begin position="533"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="274"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Moves into active site upon enzyme activation, plays a role in electron transfer" evidence="2">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="578" mass="62549" checksum="04E6E54471259B0F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDF1</accession>
    <name>A0A132PDF1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857220.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20371">
        <property type="protein sequence ID" value="KWX20371"/>
        <property type="gene ID" value="AFM11_30955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4093"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="262" mass="27006" checksum="F36408A9E240A241" modified="2016-06-08" version="1">MPTHVSTPQDLHGKRAVVTGGTRGIGRAIVERLREAGATVVAVARTASDDHPADELVVADIATPQGVATAAAEVVTRWGGADIVVHNAGGSGQHDGPTATLTDDDWLSTFNQNFFGAVRLDRLLVPGMVDRGSGVIVHVTSIQRHSPLPTTVPYAAAKAVLANYSKALSNELAPSGIRVIAVSPGYVETESAHAMAATLAELNGVDLPAARRAIMDSIGGIPLGAPGRPRDVAELVGFLVSDRAAYITGAEYVIDGGSLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDH3</accession>
    <name>A0A132PDH3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857138.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26525"/>
    <dbReference type="EnsemblBacteria" id="KWX20344">
        <property type="protein sequence ID" value="KWX20344"/>
        <property type="gene ID" value="AFM11_30805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4062"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="331" mass="35175" checksum="EEEF7F5574B20FC0" modified="2016-06-08" version="1">MRTFEFRHAASVNDAIESAASGARYYAGGTNLLDLMKNGVEKPDSLVDIGRLGLRSISATPSGGVLIESGATNSAVANHPLIRAQYPVLSQAILSGATTQLRNMATVGGNLMQRTRCPYFMDTVFDHCNKRKPGSGCAALGGFNREHALFGASAACVAVHPSDMAVALTMLDATVHVMGPDGPRSIAIADFFVLPGHHPHRENALRPAELITGVELPRSVFGSSSWYLKVRDRHSYAFALVSVAAGLQIEDGVIRAAAMALGGVAAKPWRVHEAERSLIGEPADEESYRYAADLLMTGAEPLSENGFKVQLGVNSVVRALTVAASRHDQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDZ4</accession>
    <name>A0A132PDZ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_29590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856455.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24930"/>
    <dbReference type="EnsemblBacteria" id="KWX20558">
        <property type="protein sequence ID" value="KWX20558"/>
        <property type="gene ID" value="AFM11_29590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3809"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004707">
        <property type="entry name" value="MmpL_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00833">
        <property type="entry name" value="actII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="801"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="829"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="874"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="63"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="613"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="519"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="642"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="965" mass="105309" checksum="9AAF2578D43B310B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE12</accession>
    <name>A0A132PE12_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_29655</name>
        <name evidence="5" type="ORF">AWC31_24995</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856490.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24995"/>
    <dbReference type="EnsemblBacteria" id="KWX20570">
        <property type="protein sequence ID" value="KWX20570"/>
        <property type="gene ID" value="AFM11_29655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14461">
        <property type="protein sequence ID" value="ORX14461"/>
        <property type="gene ID" value="AWC31_24995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3823"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX14461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="400" mass="44572" checksum="F10F2838E8D1015B" modified="2016-06-08" version="1">MSSTTLGPVPVFDVADPAFSITSAEVHEAREQSWYATTPYGIAVLRYEQVSRLLKHPKLRQGSVAWPAHNGVTEGPFAEWFASWILNKEGEEHHRLRRLMNPAFSPKLIGGLVPRFQALANELIDNFAEPDRCEFVSEFAEPYAARVIAIMLGIPEDEWRIISTESVTIGLALGVTLREDLPKIEAALQRLYTYCDALIADRRKNPRDDFVTALVNASRPEDGRLSDTELRDAMVLLIFGGFDTTRNQLGLAMQTFMANLEQWRLLADRPDLGGKAVEEVMRVNPTVRWVTREVLEDFEYEGAMLTAGTTVHLYSESAGTDPRVFEPGFDITAERKPHFGFGGGAHHCLGHFVARSDMSEALPLLARRLREPYELPGATWLPDSGNTGPIQLPIGFTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEB4</accession>
    <name>A0A132PEB4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856384.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20679">
        <property type="protein sequence ID" value="KWX20679"/>
        <property type="gene ID" value="AFM11_29065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3695"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="582" mass="61678" checksum="2B4A41495491590D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PED8</accession>
    <name>A0A132PED8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857133.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26515"/>
    <dbReference type="EnsemblBacteria" id="KWX20342">
        <property type="protein sequence ID" value="KWX20342"/>
        <property type="gene ID" value="AFM11_30795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4060"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="734" mass="78588" checksum="AA44F914FE6DA313" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEI7</accession>
    <name>A0A132PEI7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856055.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20756">
        <property type="protein sequence ID" value="KWX20756"/>
        <property type="gene ID" value="AFM11_28325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3539"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="551" mass="57782" checksum="3F4C46184332B26D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEJ3</accession>
    <name>A0A132PEJ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20741">
        <property type="protein sequence ID" value="KWX20741"/>
        <property type="gene ID" value="AFM11_29020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3686"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="273" mass="28177" checksum="02C6E00187073682" modified="2016-06-08" version="1">MVASSALVAGLLVAKAGHISYFFRNILLSIPLVVRRYRKEFTRVLVDISWGNGSIVVGGGTIGVAIVLGATAGALISVEGFNALNLLGLGPATGLISSFVGTRELAPVMIGLAFATQAGCRFTAQLGAMRINEEIDALDTLGINSVAYLVTTRVAAAVTAAVPLFLVCLAAAYLSAEMVAAAVSDHSVGTYMHYFNLAASGRDVFFAVVKAVVFVFAASTMQCYYGYYASGGPAGVGVAAGRAMRASITVVIIVNMLLTMALWSVDSGARFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEK5</accession>
    <name>A0A132PEK5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20760">
        <property type="protein sequence ID" value="KWX20760"/>
        <property type="gene ID" value="AFM11_28345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3543"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="122" mass="13352" checksum="78B3A01204BB2611" modified="2016-06-08" version="1">MVVAMLVAGVGGFLGFRHHQSEQRLAQIRAAVNEFAEASDTADTEKMATLMCRAEAAEFTEGFEGDLDNDGPIEPASRRPVNIESITVTGDEATVEVTRPPAPTKTFKLKREDESWKLCNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEL4</accession>
    <name>A0A132PEL4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_28465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32705"/>
    <dbReference type="EnsemblBacteria" id="KWX20779">
        <property type="protein sequence ID" value="KWX20779"/>
        <property type="gene ID" value="AFM11_28465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3571"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="51"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="86"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="112"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="307" mass="35198" checksum="8AA81F906E6A6500" modified="2016-06-08" version="1">MTDTSRETKTATTFIGARPGERHGSTADEVRSHYDLSNEFFRLWQDPTQTYSCAYFERDDMTLEEAQMAKVDLALGKLGLQPGMTLLDIGCGWGSTIMRAVEKYDVNVIGLTLSHNQLAHIEQRFAESDSKRSKEVRLQPWEEFNDPVDRIVSIGAFEHFGFEKYDYYFKKTYELMPDDGVMLLHTIVSTSKEEVAEMGLPTTMSLMRFFRFIVTEIYPGGRIPLIKMVEDSAVGAGFHVTRKQRLRPHYVKTLDTWAANLEAKKDEAIAITSEEVYERYLKYLTGCADLFRKGYTDVCQFTCEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PES0</accession>
    <name>A0A132PES0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856291.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20830">
        <property type="protein sequence ID" value="KWX20830"/>
        <property type="gene ID" value="AFM11_28815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3641"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="280" mass="31093" checksum="15509A51F507BF21" modified="2016-06-08" version="1">MDTTRELAEFLRDRRARLAPADVGIPASDRPRRTPGLRREEVAELAGVSVDYVVRLEQGRGLRPSASVLDALARALRLDTDERRYLFDLTGQRAESLDADISEEDDTGPLERLVADLSPLPAMLINHRFDVLAWNREMAALMVDFGHLPPAERNTMRLCLTHPGFRDFYLDREQVIREGIADLRAACAVHADDTALTELVESLHAQSAEFARLWALHDVRVYGRGTKRLAHPQAGELTVAFEVLAPLQNRDCRLIIYRAADAASQAALNRIVAGPSSLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEU5</accession>
    <name>A0A132PEU5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856365.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32850"/>
    <dbReference type="EnsemblBacteria" id="KWX20856">
        <property type="protein sequence ID" value="KWX20856"/>
        <property type="gene ID" value="AFM11_28595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3599"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="68" mass="7514" checksum="CB92AC09AC05972D" modified="2016-06-08" version="1">MGMTLRTSDEQTEALRRQAAAEGRSMQAVALSAIDEYIARRAHRTKVDTALQRVVAEEAGVLERLKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEU7</accession>
    <name>A0A132PEU7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin Phd</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856362.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20855">
        <property type="protein sequence ID" value="KWX20855"/>
        <property type="gene ID" value="AFM11_28575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3595"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="65" mass="7408" checksum="90761B249E9C6249" modified="2016-06-08" version="1">MPSLNIEFDEKEMEQIRAAAQADDLSLKKFVHAAVMERASMHKRRVAEAARLVAERSAELNRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEX7</accession>
    <name>A0A132PEX7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856302.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33070"/>
    <dbReference type="EnsemblBacteria" id="KWX20834">
        <property type="protein sequence ID" value="KWX20834"/>
        <property type="gene ID" value="AFM11_28840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3646"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="302" mass="30371" checksum="7D3D8121E19BBA82" modified="2016-06-08" version="1">MSALTLALDIGGTKIAAGLVDPDGLLVHQAKLPTPDGDAETVWAVVGQLLAETMKVADGRVDGVGVASAGPIDLPSGTVSPINIVEWHRFPIVERVAAATGLPVRLAGDGVCMALGEHWRGAARGADFLLGMVVSTGIGGGLVLDGAPYDGRTGNAGHVGHVIVAPENGALCTCGGHGCVETVASGPNMARWAREQGWDAPPEADAKELADAANAGDQLALKTFQRGATAIAAMIASVGAVCDLDLVVIGGGVAKSGALLFDPLRTALNDYAGLDFLRTLRVVPAELGGDAGLVGAAALLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEZ0</accession>
    <name>A0A132PEZ0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PknH_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_28385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20844">
        <property type="protein sequence ID" value="KWX20844"/>
        <property type="gene ID" value="AFM11_28385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3552"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026954">
        <property type="entry name" value="PknH-like_Extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038232">
        <property type="entry name" value="PknH-like_Extracell_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14032">
        <property type="entry name" value="PknH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PknH_C" evidence="4">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="209" mass="22640" checksum="083E67FBCCAE01EC" modified="2016-06-08" version="1">MLVLGGCTRQAEEPDGSPEVDVLGSMLASESEVNIILGTDSLRPKTALRVPAKLDPGEHASRPECVVVIGNAMDWVYRDSDYRQFRETLLADEEGNLEVDQAVIKFDSPAAAREVVTRTVSVWQQCANDTLTITEDGDKTPDLFELAAPEVVDGIDVTHDVSPDLPGYGSRRAILAVDDMVVDVRLTGYDLDDGKAVQLVKTIAGRNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF40</accession>
    <name>A0A132PF40_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855899.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10770"/>
    <dbReference type="EnsemblBacteria" id="KWX20956">
        <property type="protein sequence ID" value="KWX20956"/>
        <property type="gene ID" value="AFM11_28220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="108" mass="11735" checksum="98FCA9530F74662C" modified="2016-06-08" version="1">MRLPEALEDLPVDPETTRVFGDPHQTPDGSTVIPVSKVRRRADGRVSARPLGVFVIRGGKSTWVPAVDTTRIALLGEFIGLVAATLATAAMVRRPPWPDVRAVVSRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFE9</accession>
    <name>A0A132PFE9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_27280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855385.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07215"/>
    <dbReference type="EnsemblBacteria" id="KWX21079">
        <property type="protein sequence ID" value="KWX21079"/>
        <property type="gene ID" value="AFM11_27280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3331"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="378"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="648" mass="72167" checksum="FAA479E30F2B8F7E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFJ2</accession>
    <name>A0A132PFJ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27720</name>
        <name evidence="4" type="ORF">AWC31_10255</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX09048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855962.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20977">
        <property type="protein sequence ID" value="KWX20977"/>
        <property type="gene ID" value="AFM11_27720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09048">
        <property type="protein sequence ID" value="ORX09048"/>
        <property type="gene ID" value="AWC31_10255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3418"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453285" evidence="2">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="75" mass="7550" checksum="DE6CCE7AA598026F" modified="2016-06-08" version="1">MYLTKAALATVAAAGAIAVTAIGLGSATASADPVPPPGAPKKPAESWQGHPMVWAQLPAGGHWGVWVNGDFLPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFK2</accession>
    <name>A0A132PFK2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855529.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07480"/>
    <dbReference type="EnsemblBacteria" id="KWX21126">
        <property type="protein sequence ID" value="KWX21126"/>
        <property type="gene ID" value="AFM11_27545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3383"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="26139" checksum="333AB5C7E38BD491" modified="2016-06-08" version="1">MTPRVLFIRNEHMATEALLGEAFAECGFDIDTFDVVPAERVDSPAGDVTFPDPAGYDVIVPLGARWPVYDDALRKTWVGAEMEMVRRAADAGVGVLGICFGGQLLAQAFGGSVSRSDSPEIGWYDVATDDAELVPGGPWFQWHFDRWTLPPGATEIARTAQASQAFVLGRSLALQFHPELDSALLEGWLGDDRDGEVVGTGRSHDELRLRTKELADDAAVRVRALVRGFLDRVVRAEPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFQ8</accession>
    <name>A0A132PFQ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26400</name>
        <name evidence="2" type="ORF">AWC31_22915</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854904.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22915"/>
    <dbReference type="EnsemblBacteria" id="KWX21189">
        <property type="protein sequence ID" value="KWX21189"/>
        <property type="gene ID" value="AFM11_26400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15440">
        <property type="protein sequence ID" value="ORX15440"/>
        <property type="gene ID" value="AWC31_22915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3149"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX15440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="152" mass="16332" checksum="5F7FC429C6422769" modified="2016-06-08" version="1">MTAPVKASVSIAADPAAVYALITDLPTLASLAEEAHAMQWQKGGSATPGAVFKGHNRNGSKTWSTTCTVTDAEPGKTFAFDVKSLIFPVAHWRYDIAPTDTGCTVTESTWDRRAGWFKAIAGRATGITDRDTANAKHIELTLQRLKEKAETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFY6</accession>
    <name>A0A132PFY6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855055.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22640"/>
    <dbReference type="EnsemblBacteria" id="KWX21241">
        <property type="protein sequence ID" value="KWX21241"/>
        <property type="gene ID" value="AFM11_26695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3210"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="37"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="254" mass="27256" checksum="82EC449BD38CEA45" modified="2016-06-08" version="1">MEPVFRSLEIAARLGVRATGSQITFTGLENLPTTGGAVVAINHTSYVDFLPAGLAATERGRRMRFMIKAEMEQVKVVGFLIKHTGTIPVDRNAGAGAYAVAVKALQAGELVGVYPEATISRSFELKDFKTGAVRMALEAGVPMIPLIVWGAQRIWTKDHPKSLGRSKIPITVAVGKPVPPTGSVSELDAALRAAMSALLDEVQRDYPAPEGAYWVPRRLGGGAPTLSEAKRLDEAELAERARKRAEQEATGNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG34</accession>
    <name>A0A132PG34_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_25620</name>
        <name evidence="5" type="ORF">AWC31_36275</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854442.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36275"/>
    <dbReference type="EnsemblBacteria" id="KWX21308">
        <property type="protein sequence ID" value="KWX21308"/>
        <property type="gene ID" value="AFM11_25620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12066">
        <property type="protein sequence ID" value="ORX12066"/>
        <property type="gene ID" value="AWC31_36275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2987"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3152" evidence="3">
        <location>
            <begin position="132"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX12066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="345" mass="37623" checksum="62AC561FB8EFD185" modified="2016-06-08" version="1">MTYDPGHRGGGRVPALRNEWREPLRAQRDPLAVDSGRPRSNRDEHQHWRKQTWIGRFVSTYGWRAYALPVLIVLTVVVVYQTITGTSSSSPAHEAEGPVQGPPTIDAASTAIIGAPPKGLTQFDANLPTGILPAGGPFTEAGARTWHIVPGTTPKVGEGTTKSFTYTVEVEDGLDTTTFGGDEGFARMVSETLANPKSWTHNGLFAFTRIDAGSGIEPDFRVSLTSPITVREGCGYDIQLEASCYNPSFDGNQPRVFVNEARWVRGAVPFQGDIGSYRQYLINHEVGHAIGYQRHEACAANGELAPIMMQQTFSTSNNDAAKFDPETVQADGLTCRFNPWPYPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG85</accession>
    <name>A0A132PG85_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-CoA:3-ketoacid-CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854543.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36055"/>
    <dbReference type="EnsemblBacteria" id="KWX21345">
        <property type="protein sequence ID" value="KWX21345"/>
        <property type="gene ID" value="AFM11_25840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3032"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="262" mass="27459" checksum="088339BD603024F0" modified="2016-06-08" version="1">MTLNKVVESAAVAVADVPSGASLAVGGFGLAGIPWFLIEALLEQGADDLTIVSNNCGVDGAGLGLLLEAGRISRVIASYVGENKEFARQYLSGELTVELTPQGTLAERMRAGGSGIGAFFTPTGVGTLVAEGGLPWRYHPDGTVALASPAKEVRTFGGKEMVLEESIVTDYALVRAAVVDKAGNCKFHAAARNFNPPAAMSGRVTVVEAEQVVEVGELHPDEIHLPGIFVKRIVALTPEQAAHKDIEKRTTRPRSGSEEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGC3</accession>
    <name>A0A132PGC3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854706.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24770"/>
    <dbReference type="EnsemblBacteria" id="KWX21395">
        <property type="protein sequence ID" value="KWX21395"/>
        <property type="gene ID" value="AFM11_25510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2965"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="26007" checksum="BFEFA2D2D158C320" modified="2016-06-08" version="1">MRIAVAGATGNIGARVVRALEASGHDVVPISRARGVDLTSGDGLDAALAGVQAVVDAISAPPTDRDRTVDYLGTATANLLAAEERAGVGHHVLLSIVGIHAIEGNPHYAGKREQERLIEAGPVPWTIVPATQFHDFAEMVVGWTAQDGPDDVTAPIAPLLVQPIDPDDVAAVLAEVATGAPQGRYADVAGPQTQDLVDMARRTLAARGRDVTLVPTWSAVFGLDMSGNALLPGDGARIAPTTFDEWLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGG6</accession>
    <name>A0A132PGG6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25610</name>
        <name evidence="2" type="ORF">AWC31_36285</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854440.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36285"/>
    <dbReference type="EnsemblBacteria" id="KWX21307">
        <property type="protein sequence ID" value="KWX21307"/>
        <property type="gene ID" value="AFM11_25610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12067">
        <property type="protein sequence ID" value="ORX12067"/>
        <property type="gene ID" value="AWC31_36285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2985"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013402">
        <property type="entry name" value="CHP02569"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02569">
        <property type="entry name" value="TIGR02569_actnb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX12067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="284" mass="30780" checksum="5F88EDCA1C24B5C5" modified="2016-06-08" version="1">MTVERPPEHVLAAFGLAGVRPVPLGSSWEGGWRCGEVVLSMVADHARAAWSAKVRETLFVDGVRLARPVRSTDGRYVVAGWRADTYVAGTPEPRHDEVVSAAVRLHEATAKLERPRFLTQPPVAPWADVDVFIAADRAAWEDRPLHSLPPGARVSPGSADGQRSVELINQLAGLRRPTKSASQLVHGDLYGTVLFAGTAAPGITDITPYWRPAPWAAGVVVVDALSWGDADDGLIERWESLPEWPQMLLRALMFRLAVHALHPRSTAAAFPGLARTASLVRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGG8</accession>
    <name>A0A132PGG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853953.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26940"/>
    <dbReference type="EnsemblBacteria" id="KWX21420">
        <property type="protein sequence ID" value="KWX21420"/>
        <property type="gene ID" value="AFM11_24685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2298"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="439"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="524" mass="54838" checksum="B37094CD9156072E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGJ1</accession>
    <name>A0A132PGJ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854041.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27110"/>
    <dbReference type="EnsemblBacteria" id="KWX21450">
        <property type="protein sequence ID" value="KWX21450"/>
        <property type="gene ID" value="AFM11_24855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2332"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="21508" checksum="4B5E5B9424D26521" modified="2016-06-08" version="1">MTKLAVIYYSATGHGTTMAKRIARTAESAGAEVRLRHIAETLAPETFAQNPAWTANYEATKDDPAATGDDIVWADAVIFGSPTRFGSPTAQFRAFIDSLGGLWAQGKLADKVYAAFTSTQTAHGGQESTLLNLYVSLMHFGGIIVPPGYTDPVKFNDGNPYGVGLVANRENIAEFDDTTNDALDHLARRVVDIAGRLGGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGS8</accession>
    <name>A0A132PGS8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-phospho-L-lactate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854761.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35780"/>
    <dbReference type="EnsemblBacteria" id="KWX21417">
        <property type="protein sequence ID" value="KWX21417"/>
        <property type="gene ID" value="AFM11_26115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3088"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07186">
        <property type="entry name" value="CofD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="330" mass="35229" checksum="5E2B7FCC1F4B1165" modified="2016-06-08" version="1">MKITVLVGGVGGARFLLGVQNLLRLGSFSDDPGNPGEHELTAIVNVGDDAWMHGVRICPDLDTCMYTLGGGIDPERGWGHRNETWHAKEELAAYGVQPDWFGLGDRDLATHLVRSQMLRAGYPLSQVTEALCKRWSPGARLLPVTDDRSETHVVITDPADGERRAIHFQEWWVRYRAKVPSHSFAFIGAEQATAGPGVTEAIAEADVVLLAPSNPVVSVGPILQIPGIRGALRSTAAPVIGYSPIIAGKPLRGMADECLSIIGVESTSEGVGRWFGAKSGTGILDGWLVHEGDHAEIEGVEVRAVPLLMTDPPTTAKMVQAGLDIAGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGY3</accession>
    <name>A0A132PGY3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_25285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854243.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27605"/>
    <dbReference type="EnsemblBacteria" id="KWX21524">
        <property type="protein sequence ID" value="KWX21524"/>
        <property type="gene ID" value="AFM11_25285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2419"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="18"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="497" mass="52062" checksum="89AE4325EE2EBAF5" modified="2016-06-08" version="1">MSTVIQHWRDGKVFAGSSTATAPVTNPATGAVTGEVALASVEDARAVIDAAVAAFPAWRDTSLAKRTSVLFAFRELLNARKDELAALITAEHGKVLSDALGEVSRGLEVVEFACGIPSLLKGGFTENASTNVDVHSVLQPLGPVGIISPFNFPAMVPMWFFPIAIAAGNTVVLKPSEKDPSASLWMARLWAEAGLPDGVFNVLQGDKTAVDELLTNPKIKAISFVGSTPIAQYVYATATATGKRVQALGGAKNHAVILPDADLDLAADAMVNAGFGSAGERCMAISAAVAVGPIADDLVAKIAERAATIKTGDGTKDSDMGPLVTKVHRDKVASYIDAGEAAGAKVVLDGRTVIANGGENGFWLGPTLLDNVTPEMSVYTDEIFGPVLSVLRVDTYDEALELINSNPYGNGTAIFTNDGGAARRFQNEVEVGMVGINVPIPVPMAYFSFGGWKASLFGDSHAHGAEGVHFFTRTKAITTRWLDPSHGGINLGFPENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH34</accession>
    <name>A0A132PH34_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cutinase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_24195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23920"/>
    <dbReference type="EnsemblBacteria" id="KWX21631">
        <property type="protein sequence ID" value="KWX21631"/>
        <property type="gene ID" value="AFM11_24195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2198"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007356431" description="Cutinase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="221" mass="22510" checksum="6FEBA739B11CEA71" modified="2016-06-08" version="1">MGGHKGSRAGLVAAAVSAVAAAGLIVPPVAAAAPDCPDIEVIFARGTDEPAGIGVVGQAFVDTLKPMVKGSTVGSYAVKYPASWDFMKAAAGATDMSKRVQSTVAKCPRTQIVLGGYSQGAAVVDVVATSPVAGLGYTAPLPAAVVPHIASIVVFGNPSARIGQPLTRMSPVFGSRTADLCAPADPICSLGRNWDAHISYPKTGLVKLAAQWVTRHIKPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH56</accession>
    <name>A0A132PH56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853782.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23590"/>
    <dbReference type="EnsemblBacteria" id="KWX21679">
        <property type="protein sequence ID" value="KWX21679"/>
        <property type="gene ID" value="AFM11_24530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2267"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453270" evidence="2">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="181" mass="18146" checksum="8166D3093EBBE286" modified="2016-06-08" version="1">MSTPVNHAARMRGGLVGACSALTAAVAHTAAGGAAPSSSPLVVLVMLCATLGAVVGGFTPETRVGRTALLIAGLGAGQTLGHLALSLTGGHHHATSLLSAPMLGLHVAAAVGLGLLIGVVEYLYVVCASVLCWLRVFFILGRVRPAGHAVWWPSDTVVARPVLLRAGLGMRAPPVVCPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHI7</accession>
    <name>A0A132PHI7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppk</name>
        <name evidence="13" type="ORF">AFM11_24985</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854102.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27240"/>
    <dbReference type="EnsemblBacteria" id="KWX21472">
        <property type="protein sequence ID" value="KWX21472"/>
        <property type="gene ID" value="AFM11_24985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2358"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="10">
        <location>
            <begin position="59"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="9">
        <location>
            <begin position="174"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="12">
        <location>
            <begin position="383"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="11">
        <location>
            <begin position="556"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX21472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="735" mass="82083" checksum="68ED5CC77BEC7E4A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHV3</accession>
    <name>A0A132PHV3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argC</name>
        <name evidence="7" type="ORF">AFM11_22340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852693.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08870"/>
    <dbReference type="EnsemblBacteria" id="KWX21915">
        <property type="protein sequence ID" value="KWX21915"/>
        <property type="gene ID" value="AFM11_22340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1818"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="349" mass="35721" checksum="5173354065D60482" modified="2016-06-08" version="1">MQNRCMTSVAVAGASGYAGGEILRLLLGHPAYADGRLTIGALTAASSAGTSLAEHHPHLLPLVSRVLENTDVSVLAGHDVVFLALPHGHSAALAEQLGPDTLIVDCGADFRLTDAADWERFYGSAHAGSWPYGLPELPGARERLRGAKRVAVPGCYPTAALLAMLPAVAADLVEPAVTVVAVSGTSGAGRSAKVDLLGSEVIGSARAYNVGGKHRHTPEIAQGLQAVTSKKVTVSFTPVLIPASRGILATCTARTSATTSEIRAAYEKAYDAEPFIYLLPEGQLPKTGSVIGSNAAQLAVAVDEDAQTLVAIAAIDNLVKGTGGAAVQSMNLALGWPETEGLSIVGVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHX0</accession>
    <name>A0A132PHX0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCTP deaminase, dUMP-forming</fullName>
            <ecNumber evidence="3">3.5.4.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Bifunctional dCTP deaminase:dUTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">DCD-DUT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dcd</name>
        <name evidence="6" type="ORF">AFM11_23330</name>
        <name evidence="7" type="ORF">AWC31_28055</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dCTP + 2 H2O = diphosphate + dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19205"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.30" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853131.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28055"/>
    <dbReference type="EnsemblBacteria" id="KWX21787">
        <property type="protein sequence ID" value="KWX21787"/>
        <property type="gene ID" value="AFM11_23330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14988">
        <property type="protein sequence ID" value="ORX14988"/>
        <property type="gene ID" value="AWC31_28055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2021"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033973">
        <property type="term" value="F:dCTP deaminase (dUMP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="101"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for bifunctional activity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX14988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="189" mass="20678" checksum="A29F8B142A1A0278" modified="2016-06-08" version="1">MLLSDRDIRAEIAAKRLALEPFDDAMVQPSSIDVRLDSLFRVFNNTRYTHIDPSIQQDELTSLVEPAEGEPFVLHPGEFVLGSTLELCTLPDDLAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCLLRLTSPAEHPYGSDKVGSKYQGQRGPTPSRSHLNFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI20</accession>
    <name>A0A132PI20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22780</name>
        <name evidence="4" type="ORF">AWC31_08420</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852970.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08420"/>
    <dbReference type="EnsemblBacteria" id="KWX21985">
        <property type="protein sequence ID" value="KWX21985"/>
        <property type="gene ID" value="AFM11_22780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10184">
        <property type="protein sequence ID" value="ORX10184"/>
        <property type="gene ID" value="AWC31_08420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1909"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453268" evidence="2">
        <location>
            <begin position="27"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX10184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="158" mass="15930" checksum="C022ED4A483F06FE" modified="2016-06-08" version="1">MSAQPAPRAFSTVFGLLMAAATAAPADGPALVAAALAAVGVLVALLLRPVATAAVVAAASALALSEPEPVFAALAGLSAVAYLVIRYAVGTPEVVTTTRPTMLTAIGFTVLALAAAALPVTVPWVPLLAPLVAGVVYLLALRPFIGEQRWTAANYRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI77</accession>
    <name>A0A132PI77_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="11" type="ORF">AFM11_22755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08445"/>
    <dbReference type="EnsemblBacteria" id="KWX22050">
        <property type="protein sequence ID" value="KWX22050"/>
        <property type="gene ID" value="AFM11_22755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1903"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="256"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX22050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="575" mass="61199" checksum="0EEE58158C019A51" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIL2</accession>
    <name>A0A132PIL2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21900</name>
        <name evidence="3" type="ORF">AWC31_04705</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852474.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04705"/>
    <dbReference type="EnsemblBacteria" id="KWX22151">
        <property type="protein sequence ID" value="KWX22151"/>
        <property type="gene ID" value="AFM11_21900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10591">
        <property type="protein sequence ID" value="ORX10591"/>
        <property type="gene ID" value="AWC31_04705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1728"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="157" mass="17791" checksum="81A083724237E875" modified="2016-06-08" version="1">MTVALRRSWAKDLDVPTLYELLKLRIEVFVVEQATPYPELDGRDLLAETRHFWLEGPDGEVISTLRLMEEHPGGEKAFRIGRVCTKRSARGHGHTTRLMQAALAEVGDYPCHINAQTYLEDMYAQHGFVRDGDEFLDDGIPHVPMVRAGSRVDTEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIM7</accession>
    <name>A0A132PIM7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852590.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04315"/>
    <dbReference type="EnsemblBacteria" id="KWX22209">
        <property type="protein sequence ID" value="KWX22209"/>
        <property type="gene ID" value="AFM11_21500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1648"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="2">
        <location>
            <begin position="30"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="261" mass="26980" checksum="B0B6BF7A691CB5AD" modified="2016-06-08" version="1">MSVSRLQDALAANATIWGGWVVGPTIIGPEEFAHAGYHYVGFDVQHGYLDDADVALLLRRLEHVPIATAVRLPSPDPAPIGRVLDAGADAVIIAMVETPEQAAAAVAATRYAPDGVRSFGPLRASLGHDTAALESRASVFAMIETAQGVSEVDRICAVPGLSGVYVGPADLAISLGHRVADAWTHPDVRAAMVTIRSAAAAAGIVSGIHAGTGRLGRAMADLGFQMVTLASESQALRRGAAEHLDEAAGHTHDESAQGGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIP7</accession>
    <name>A0A132PIP7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_20580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852001.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05995"/>
    <dbReference type="EnsemblBacteria" id="KWX22238">
        <property type="protein sequence ID" value="KWX22238"/>
        <property type="gene ID" value="AFM11_20580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1453"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="28695" checksum="4661F5C91A7C99DB" modified="2016-06-08" version="1">MLALILSLAVLVGVSLGVLGGGGSILTVPLLAYVAGLDARQAITTSLLVVGVTSVIGAVTHARAGHVQWRTGLLFGVTGTAGAYAGGLIGHLLPGSVLLTAFAVVMIATAVAMLNRRRACTAPAVRTPAVKTLLMGLVVGVVTGTLGAGGGFVVVPALALLGGLPMPIAVGTSLIVIAMNSFAGLAGQLSTAPIDWPLAAMVTAAAVAGSLLGARLTARVDPDTLRRAFGWFVLAMASIILAEEVHPVVGLVAGAATAIGAFYYFVCRRYAWCPVQRLFGPPAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIS8</accession>
    <name>A0A132PIS8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20755</name>
        <name evidence="4" type="ORF">AWC31_06170</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852066.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06170"/>
    <dbReference type="EnsemblBacteria" id="KWX22268">
        <property type="protein sequence ID" value="KWX22268"/>
        <property type="gene ID" value="AFM11_20755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09800">
        <property type="protein sequence ID" value="ORX09800"/>
        <property type="gene ID" value="AWC31_06170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1490"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="131" mass="14238" checksum="A4EBE48564A5DF85" modified="2016-06-08" version="1">MTGAVRSTRQRAAIADLLNETDGFRSAQELHDELRRRGQGIGLTTVYRTLQAMATAGVVDTLRTDTGESVYRRCSEHHHHHLVCRACGSTVEVSGPDVETWAADVAREHGFSDVSHTIEIFGVCGECVGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJJ2</accession>
    <name>A0A132PJJ2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_20370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the carbamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851948.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22505">
        <property type="protein sequence ID" value="KWX22505"/>
        <property type="gene ID" value="AFM11_20370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1408"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00746">
        <property type="entry name" value="arcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="309" mass="32815" checksum="EB1E3D8A07D86101" modified="2016-06-08" version="1">MRIVIALGGNAILQRGQPMTAENQRANIRVAAERIADVTQGNEIVVAHGNGPQVGLLALQAAAYHSAHQDVAPYPLDVLGAQTEAMIGYVIEQELDNLLPSDQPLATMLTMIEVDRDDPAFHHPTKPIGPVYDRETAERLKTVSGWAIAPDGDKFRRVVPSPKPKRIFEIRPIRSLVDQGTIVICAGGGGIPTMYDEHGRLQGVEAVIDKDLASALLAEQLHADLLVIATDVDGAYTGWGTPDQRRLGRVTPDELAGLEFPAGSMGPKVEAACGFARNTGKEAVIGSLTDISKIVAGVAGTRVSVSSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK99</accession>
    <name>A0A132PK99_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851098.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22770">
        <property type="protein sequence ID" value="KWX22770"/>
        <property type="gene ID" value="AFM11_17615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.878"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="67" mass="7289" checksum="E6110339AAC65155" modified="2016-06-08" version="1">MGLGDHPMRTPFYGVLLVIGAVLLAWLVASTLTGWQAAVGYFLAIAVGAVGFVMTLRDLDNFPNWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKA8</accession>
    <name>A0A132PKA8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">miaA</name>
        <name evidence="9" type="ORF">AFM11_17685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851119.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11805"/>
    <dbReference type="EnsemblBacteria" id="KWX22780">
        <property type="protein sequence ID" value="KWX22780"/>
        <property type="gene ID" value="AFM11_17685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.892"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="306" mass="33215" checksum="5736E4C66DEFFA7C" modified="2016-06-08" version="1">MTRPIAIIGPTGTGKSALALDFAERLSGEIGVEIVNADAMQLYRGMDIGTAKLTVAERRGIPHHQLDVLEVTETATVARYQEAAAADIEAIAARGAVPVIVGGSMLYIQSLLDEWSFPATDPAVRARWEARLAEVGVAALHAELTRVDPAAGASILPTDGRRIVRALEVVELTGQPFAASAPRIGTPRWDTAIVGLDWETELLDERLAQRADKMFAEGLVDEVRGLIDRGLRQGVTAARALGYAQVLDDFDAGGDGSGAREPTFIGTRRYVRRQRSWFRRDHRVVWLDGSGDGLVDEAMRVWQHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKB7</accession>
    <name>A0A132PKB7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851669.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22637">
        <property type="protein sequence ID" value="KWX22637"/>
        <property type="gene ID" value="AFM11_19250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1184"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="348" mass="37529" checksum="08FD8A56ABBA1A20" modified="2016-06-08" version="1">MSKTLIAGAHGVIGGAVARAAAEQGRDIVTVARRGPVSHNGGVLGEHIAVDLLDRDSTVTALSTRADIDSVVFAAYIEKPTMAETIALNVTMLANLLDGLAAHPVRRVVLIGGGKSYGEHLGGYKTPAKESDPRFLGPIFYNDQEDLLVEHAERHGYSWTVLRPDAVIGPSLGSPMNMLTGVAVYATICKHLGVPLRFPGTNGAWTALHQATDARVVADATLWALEASSAENEIFNVTNGDHFRWQHLWAEIAADFGMDTAAPQPMSLQEQMADKAAVWNRIVTQHGLLPLSLDRAVSWPFVDDWFGNDGDMVQSTIKIRQAGFGGCLDTHQSFIENFATLRALNFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKK0</accession>
    <name>A0A132PKK0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851106.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05155"/>
    <dbReference type="EnsemblBacteria" id="KWX22774">
        <property type="protein sequence ID" value="KWX22774"/>
        <property type="gene ID" value="AFM11_17635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.882"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="178" mass="18555" checksum="A3C7654A84DFA45B" modified="2016-06-08" version="1">MNGEVVILTGPPGSGKTTAADIVAGAADRPTVHLTTDQFYRAIRAGYIPPFLPEAQAQNEVVIDAIVAAVAAYAGGGFDVVVDGIVGPWFLGPFRDLAARAGITLSYIVLRPTLQTALARAQARSGDDLKDPDAITGLHSAFAELDGLESHVIDNSALDASGTAERVRQAIASGRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKU4</accession>
    <name>A0A132PKU4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitronate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850627.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19875"/>
    <dbReference type="EnsemblBacteria" id="KWX22969">
        <property type="protein sequence ID" value="KWX22969"/>
        <property type="gene ID" value="AFM11_16445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.637"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="6"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="337" mass="35680" checksum="1AB078BFE6977DDC" modified="2016-06-08" version="1">MALNTKFTETFGVEHPIVQGGMQWVGRAELVAAVANSGALGFITALTQPTPADLAKEIERCRELTDKPFGVNLTILPTINPPPYDEYRQVIVDSGVKIVETAGSNPAPHLPMFHDNGIKVLHKCTSVRHAVKAQSLGVDGISIDGFECAGHPGEDDIPGLVLIPAAAAKIEIPMIASGGFADARGLVAALALGADGINMGSRFMCTVESAIHQKVKEAIVAGTELDTELIFRPLRNTARVASNAVSREVVQILNNGGQFEDVKDLVAGKRGVKVYEIGDLDAGIWSVGTSMGLINDIPTVGELVSRMVTEAEILISGRLLNMIGADEDDLKKETVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL72</accession>
    <name>A0A132PL72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851058.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05010"/>
    <dbReference type="EnsemblBacteria" id="KWX22752">
        <property type="protein sequence ID" value="KWX22752"/>
        <property type="gene ID" value="AFM11_17490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.853"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="399" mass="44177" checksum="7A415522A2CC2961" modified="2016-06-08" version="1">MATLTTAQARRVAVAAQGFHEPRPRGPVSRAHLRRLISRIQVLQLDSVSVAVRAHYAPVFSRLGPYDRDVLDRAAWAHSARSPRLLVEYWAHEAALMAVEDWPLLRWRMREYTHGRWGTEIVKKNPKLAEDIVAAVAELGPSTAGQIEAHLEAEPRGRKGPWWDRSETKWVAEALFAAGVLTTATRVGFARHYDLAENVLPPEVLAREVDDDEAIRELTLRAATALGVGTEADIRDYFRLGAKQVKPAIAKLVADGELEPVDIDGTPAYLRAGQIVPRRDRGTALLCPFDPLIFFRPRVERLFGFHYRIEIYTPAPKRQFGYYVWPFLLDGELVGRVDLKRTDAALQVLGAYTEDGQDRSRVATALAAELASMAGWLGVDAVDVGSRGDLAGPLGSVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLA7</accession>
    <name>A0A132PLA7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-5'-phosphate-dependent protein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_17375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850969.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01960"/>
    <dbReference type="EnsemblBacteria" id="KWX23129">
        <property type="protein sequence ID" value="KWX23129"/>
        <property type="gene ID" value="AFM11_17375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.829"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="26"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="365" mass="39615" checksum="1CAD96552D252405" modified="2016-06-08" version="1">MNHVLFKDHRTTHAGLRRNRGPNTMVGHTPALWISAPFTGDGRGFWAKLEGYNPGGMKDRPAMHMVERARSRGDLKPGARIIESTSGTLGLGLAFAGTVYHHPVTLVTDPGLEPIIARMLTAYGADIEPVTRPHPTGGWQQARRDRVAELLAAHPGSWYPDQYNNPDNVDAYRPLALELAAQLGWIDVLVCSVGTGGHSAGVARVLRESNPRLKLIGVDTIGSTIFGQPAATRIMRGLGSSIYPRNVDYAAFDEVHWIAPAEAVWACRTLASTYYASGGWSVGAVSVVAGWAARNHPADTTIAAVFPDGPQRYFDTVYNDDYCREHGLLDGPPPREPEVIDRPGGRVVASWTRCTTVVDPMAVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMA4</accession>
    <name>A0A132PMA4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849808.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18435"/>
    <dbReference type="EnsemblBacteria" id="KWX23468">
        <property type="protein sequence ID" value="KWX23468"/>
        <property type="gene ID" value="AFM11_14385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6985"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="680" mass="72852" checksum="7F1A8C26B97E448A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMB5</accession>
    <name>A0A132PMB5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14475</name>
        <name evidence="4" type="ORF">AWC31_18350</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849835.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18350"/>
    <dbReference type="EnsemblBacteria" id="KWX23481">
        <property type="protein sequence ID" value="KWX23481"/>
        <property type="gene ID" value="AFM11_14475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17274">
        <property type="protein sequence ID" value="ORX17274"/>
        <property type="gene ID" value="AWC31_18350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7003"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453417" evidence="1">
        <location>
            <begin position="31"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="160"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX17274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="491" mass="51224" checksum="E2C6EDC8EE78E327" modified="2016-06-08" version="1">MNTSLRRVAVAIMVLIVLLLANATMTQVFTADGLRADPRNQRVLLDEYSRQRGQISAGGQLLAYSVATDGRFRYLRVYPDPQAYAPVTGFYSLAYSSTGLERAEDTILNGSDERLFGRRLADFFTGRDPRGGNVDTTIKPQVQQAAWNAMQTGCDGPCRGSVVALEPSTGKILAMVSAPSYDPNLLATHDLNAQTTAWEQLRDDSQSPLLNRAISETYPPGSTFKVITTAAALQAGATPDTQLTSAARTSLPDSTATLENFGGAACGPGPTTSLRDAFAKSCNTAFVELGLDTGADKLKATAQAFGLDAPPPAIPLQVAESTTGPILDGAALGMSSIGQRDVALTPLQNAQVAATIANDGISMRPYLVDNLKGPDLATISTTAPVQERRAVSPQVAATLTDLMVAAEQVTQQKGAIAGVQIASKTGTAEHGTDPRNTPPHAWYIAFAPASDPKVAVAVLVEDGGDRLSATGGALAAPIGRATIAAALREGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMQ1</accession>
    <name>A0A132PMQ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848904.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02730"/>
    <dbReference type="EnsemblBacteria" id="KWX23616">
        <property type="protein sequence ID" value="KWX23616"/>
        <property type="gene ID" value="AFM11_12470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6584"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="289" mass="31190" checksum="C21C052393433B18" modified="2016-06-08" version="1">MSKNPLRALADQVLLTSMRPPLTERLQGRDDIELAGKRILLTGASSGIGEAAAEKFAARGATVIAVARRQELLDALVDRITAKGGDARAHAVDLSDLDAVDGLVADVEQDLGGVDILINNAGRSIRRPLAESLERWHDVERTMTLNYYSPLRLIRGLAPGMRERRDGHIVNVSTWGVMNESSPLFAVYNASKAALSAVSRVIETEWAAVGVHSTTLYYPLVKTPMIAPTRAYDGLPGLSAQEAADWMVTAARTRPVQIAPRMAVTAKAINSVLPGVVDAVMKRQRVQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMR7</accession>
    <name>A0A132PMR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12535</name>
        <name evidence="3" type="ORF">AWC31_02795</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848947.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02795"/>
    <dbReference type="EnsemblBacteria" id="KWX23628">
        <property type="protein sequence ID" value="KWX23628"/>
        <property type="gene ID" value="AFM11_12535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11079">
        <property type="protein sequence ID" value="ORX11079"/>
        <property type="gene ID" value="AWC31_02795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6597"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="94" mass="9697" checksum="9D4EDA32FA68B631" modified="2016-06-08" version="1">MIYLESIFKVLVVGLILGAGLPAVFALGLVAYSNGAGGTHEDGTVQAANPALKTLGLVLFASVAAVIVIAILWITKATIIHHFGFNPVPFLPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMS2</accession>
    <name>A0A132PMS2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_16170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850491.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16775"/>
    <dbReference type="EnsemblBacteria" id="KWX23342">
        <property type="protein sequence ID" value="KWX23342"/>
        <property type="gene ID" value="AFM11_16170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7359"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="30010" checksum="953E4F025CF1A50E" modified="2016-06-08" version="1">MPTFVLAQSNLALGYQHNWWQILTSSFMRNALIGGTLVALAAGLIGYFIIVRNTAFAAHALAHIGLPGATGAALLGLPVVLGLGVFCIGGALVIGALGKRADDREVATGTVLALATGFGLFFNSLATKNSSTLTNVLFGNLLAITHQQLLTFTALLVLLAATVVLVYRPLLFASVNAQVAEAKGVPVRALSVLFMALLGVAVTMAVQAVGTLLLFALVVTPAATAIMLTAQPLAAMAISTGISLVSVWAGLAVSAIFNMPPSFVIVTIACVFWLAVWAAQRATRSAMGSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMY0</accession>
    <name>A0A132PMY0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12980</name>
        <name evidence="4" type="ORF">AWC31_03265</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849165.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03265"/>
    <dbReference type="EnsemblBacteria" id="KWX23698">
        <property type="protein sequence ID" value="KWX23698"/>
        <property type="gene ID" value="AFM11_12980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11157">
        <property type="protein sequence ID" value="ORX11157"/>
        <property type="gene ID" value="AWC31_03265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6688"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="300" mass="31485" checksum="8B92C9AAB5EAE3B0" modified="2016-06-08" version="1">MSESGSADAPAQELGGEASAEAAVTDLAADLEADASAGPSAPPPDLTAAAFFDVDNTLVHGSSLVHFARGLAARKYFTYSDILGIVYAQAKFQFTGKENSDDVAAGRRKALAFIEGRSTAELVELGEEIYDQIIADKIWPGTRALAQMHLDAGQQVWLVTATPYELAATIAKRLGLTGALGTVAESVDGVFTGRLVGDILHGTGKAHAVRSLAIREGLNLRRCTAYSDSFNDVPMLSLVGTAVAINPDAALRDVARERGWEIRDFRTARKAARIGVPSALALGALGGALAAVASRRHDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNF4</accession>
    <name>A0A132PNF4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Keratin associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849563.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23860">
        <property type="protein sequence ID" value="KWX23860"/>
        <property type="gene ID" value="AFM11_12755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6642"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0416">Keratin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453436" evidence="1">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="82" mass="8408" checksum="63848016C8F89B68" modified="2016-06-08" version="1">MTNRTRISTVLALGAGALAIAVAPAAQAAPSGPTCTSAVTSTLCQSNGNAQFTATPPAVDYQAQYPFFGEYGLIFHHGGDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNH1</accession>
    <name>A0A132PNH1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_13695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849477.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03940"/>
    <dbReference type="EnsemblBacteria" id="KWX23814">
        <property type="protein sequence ID" value="KWX23814"/>
        <property type="gene ID" value="AFM11_13695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6835"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="214"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="590"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="735" mass="78214" checksum="956CD857FD9C56C8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNM4</accession>
    <name>A0A132PNM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11075</name>
        <name evidence="3" type="ORF">AWC31_31180</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31180"/>
    <dbReference type="EnsemblBacteria" id="KWX23915">
        <property type="protein sequence ID" value="KWX23915"/>
        <property type="gene ID" value="AFM11_11075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12447">
        <property type="protein sequence ID" value="ORX12447"/>
        <property type="gene ID" value="AWC31_31180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6291"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX12447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="325" mass="35847" checksum="D9AD2DAC74D19CBE" modified="2016-06-08" version="1">MRNREDDALPATFGLAIENFTSADKTPQINELLSTARRAEQLGFTSLWAWDHLFLGSRQPFPQLEALTTLAVLASHTTTITLGTGVLVLPIRDPALLAKTAATIQAVSDGRLRLGMAAGWYEREFDATGTPFKNRGKIFERNLEVCMNLWTQDEVTGTWDDLSFRRVKMLPLPKPRPQVLIGGYVDRVLKRVATLGDGWLTYFYTAEAFAESWAKISRFAEQAGRDPDQLHSLNQLPICIGSSKEQAQALTGPWLASYFDTPEWSNATPDSAICGTPEDCAEQIAAHLDAGVREICLVPHAYDPEQVERFAAEVRPLLGSLVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNX8</accession>
    <name>A0A132PNX8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_13705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849631.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03950"/>
    <dbReference type="EnsemblBacteria" id="KWX23897">
        <property type="protein sequence ID" value="KWX23897"/>
        <property type="gene ID" value="AFM11_13705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6837"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453210" evidence="4">
        <location>
            <begin position="21"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="5">
        <location>
            <begin position="143"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="6">
        <location>
            <begin position="255"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="503" mass="52860" checksum="7FA631CE4B93A5E1" modified="2016-06-08" version="1">MRRSLTGAVLGAVVLTVALAGCDAKTELQSDTPTQEAQTSSPAATEFANQLRERVSADAMMGHLTKLQEIADAHDGNRALGTAGYDASVEFVANALRDKGFDVQTPEFEVRLPFSEDPQVTVGGQPVTARPLEFTIGTRPEGVSGPLVAARAEDSPGCEASDYDGLPVAGAVVLVDRGACPFGAKQAAAAERGAVAMIVANNVDGDEMGGTLGRRTDVKIPVVSVTKDDGERLRANPGPTTIRLNAGVRTERTRNVIAQTKTGSTSDVVMVGAHLDSVPEGPGINDNGSGVAAVLETALQLGSSPDVNNAVRFGFWGAEEEGLLGSTNYVESLDTEGLKDIALYLNFDMLGSPNPGYFTYDGDQSAPIEGRGVPRVPEGSAGIERTLAAYLADAGKMPQDTSFDGRSDYDGFTLAGIPAGGLFSGAEDKMTAEQAQEWGGQADQPFDPNYHKNTDTLEHVDRDALQIHGEGVAFAVGLYAQDQRGRNGIPIRSDRTRHEISPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP23</accession>
    <name>A0A132PP23_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848577.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09910"/>
    <dbReference type="EnsemblBacteria" id="KWX24089">
        <property type="protein sequence ID" value="KWX24089"/>
        <property type="gene ID" value="AFM11_12065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6492"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="215"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="421" mass="45194" checksum="8A09EDE1F6E2AA6C" modified="2016-06-08" version="1">MLIRRASLIDGAVVDIRVGERIEEVAASLPESEPVLDAAFGTVIPGLHDHHLHVYSAAAEHDSIRVGPNDVRDAAQLRHALTTAQPGGDGWIRAVGYHEVVAGPLDRHRLDELTSTVPVRIQHRSGVLWMLNSAGLEAVGRPDHPDGRLRSADPTWAEPLQRRQIQVGQFSERLARYGVTGVTDATPDLDALPTGLRQRVHRLAPGKRILHDDDLDLDALTAWIGRRHDDGNPVAIHCVTAAQLIVTIAALRVAGIHPADRIEHAAMVPDDCIADLVDLGVTVVTQPNFVAERGDQYRTDVAETEQDQLWRLATLSAAGIPVALSTDAPFGDADPWAAMRAAVHRRTPRGVVLNPAERVSARTALEMFCGVAEHPAVPRTIAPGQPADLCVLSAGPAQVLDQLDADLVAATIVGGVVVFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP70</accession>
    <name>A0A132PP70_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848748.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09625"/>
    <dbReference type="EnsemblBacteria" id="KWX24138">
        <property type="protein sequence ID" value="KWX24138"/>
        <property type="gene ID" value="AFM11_12355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6550"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="177" mass="18519" checksum="2552F4FDBAC6D116" modified="2016-06-08" version="1">MTVKLPTGAVTLMAGAEGSARLWQTQPDDMAAALPWLRTTAVHLIALNDGILRSGLDNTEGFVATFGRASDALSCALALQLAPTDPFSLCIGVHSVADGAAKLCDVAHGGQTLISGTTVSSGFGGLPAGATLTHLGSHRLDDPQWQERLFELRHPGLPKRIQLLDVPQAVLAHDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPD9</accession>
    <name>A0A132PPD9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09370</name>
        <name evidence="4" type="ORF">AWC31_05855</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847065.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05855"/>
    <dbReference type="EnsemblBacteria" id="KWX24200">
        <property type="protein sequence ID" value="KWX24200"/>
        <property type="gene ID" value="AFM11_09370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09749">
        <property type="protein sequence ID" value="ORX09749"/>
        <property type="gene ID" value="AWC31_05855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5911"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04623">
        <property type="entry name" value="CBS_pair_bac_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044725">
        <property type="entry name" value="CBSX3_CBS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="143" mass="15425" checksum="DC1A46483614A413" modified="2016-06-08" version="1">MRIADVLKNKGAAVATISPETTVTELLAGLAEMNIGAMVVIGPDGLIGIVSERDVVRKLHERGSSLLAQPVSEIMTTVVATCTPRDTVDHLSVLMTENRVRHIPVLDNGRLAGIVSIGDIVKTRMEELEAEQQQLQAYITQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPP5</accession>
    <name>A0A132PPP5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_09610</name>
        <name evidence="8" type="ORF">AWC31_05615</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847206.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05615"/>
    <dbReference type="EnsemblBacteria" id="KWX24244">
        <property type="protein sequence ID" value="KWX24244"/>
        <property type="gene ID" value="AFM11_09610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09704">
        <property type="protein sequence ID" value="ORX09704"/>
        <property type="gene ID" value="AWC31_05615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5959"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="6">
        <location>
            <begin position="20"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX09704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="444" mass="46900" checksum="0493BF0D337A3AB1" modified="2016-06-08" version="1">MPPEVEDAVTSMAAVNNEFFYWMSIALMMLIHAGFLAYEMGASRSKNVLATAMKNLLAFACIVASFFFVGWFLYNAMPAGYPRIDELAAAALPWSDNMGPNVEDPVSGIFWGAFALFAATTGSIMSGAVLERIRTSAFLILTVFVGSVVWIIGAAWGWHGAGWMLTKLGFHDVGAAGCVHMIAGFATLGILINLGPRLGRFLPDGTAVTIRPHNLPLTMLGLMLIFAGFFGFLMGCVIYGPDGYATIYGSPTTLSAFAFNTLMGLAGGIIGAYLTSRGEPFWTISGGLAGVIAVASGMDLYHPALAFIIALAGGALSPYLGKLLERFRIDDVVGAVTVHAGMGTYSLLMAGIFLSGYPNTDGNPPISLWGQLIGIAVFAALGFIPTYLVALGLKKMKLLRIPPEVEEQGLDLSEVPATPYPEGIPMTVMPVNGAKALVGAVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPT2</accession>
    <name>A0A132PPT2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_10235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847529.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18680"/>
    <dbReference type="EnsemblBacteria" id="KWX24349">
        <property type="protein sequence ID" value="KWX24349"/>
        <property type="gene ID" value="AFM11_10235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6085"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="236"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="386" mass="41224" checksum="6CF34AF4D197F81D" modified="2016-06-08" version="1">MSDFLSTGTLPDHYEQLAKTVRDFAQSVVAPVAAKHDEEHSFPYEVVVGMADMGLFGLPFPEEYGGMGGDYFALCLALEELGKVDQSVAITLEAGVSLGAMPVYRFGNDAQKQEWLPLLASGKALGAFGLTEAGGGSDAGATKTTAKLDDGHWIINGSKQFITNSGTDITKLVTVTAVTGEREGKKEISSILVPVPIEGFTAEPAYNKVGWNASDTHPLSFDDVRVPAENLLGERGRGYANFLRILDEGRIAIAALSVGVAQGCVDECVRYAKERQAFGAAIGTYQAIAFKIARMEARAHTARAAYYDAAALMLAGKPFKKAASVAKLVSSEAAMDNARDATQIFGGYGFMNEYPVARHYRDSKILEIGEGTTEVQLMLIAREAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPX2</accession>
    <name>A0A132PPX2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10550</name>
        <name evidence="3" type="ORF">AWC31_18985</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX16933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847678.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18985"/>
    <dbReference type="EnsemblBacteria" id="KWX24396">
        <property type="protein sequence ID" value="KWX24396"/>
        <property type="gene ID" value="AFM11_10550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16933">
        <property type="protein sequence ID" value="ORX16933"/>
        <property type="gene ID" value="AWC31_18985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6150"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="285" mass="29820" checksum="474754B7A25A5F9E" modified="2016-06-08" version="1">MGTTTILRSTYPRLARQFTKPVSTLSRVGDHTLFYVKALAGTPHAAIHYRKELVRLIAEISMGAGTLAMIGGTVVIVGFLTLATGGVLAIQGYSSLGNIGIEALTGFLAAFINVRIAAPVVAGIGLAATFGAGVTAQLGAMRINEEIDALESMAIRPVEYLVSTRIVAGMIAITPLYAIAVILSFLASQFTTVVLLGQSGGLYDHYFNTFLNPIDLLWSFLQAVLMALTILLIHTYFGYFASGGPSGVGVAVGNAVRTSLIVVVSVTLLVSLSVYGSNGNFNLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPZ9</accession>
    <name>A0A132PPZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_09805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847927.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05420"/>
    <dbReference type="EnsemblBacteria" id="KWX24277">
        <property type="protein sequence ID" value="KWX24277"/>
        <property type="gene ID" value="AFM11_09805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5999"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="28360" checksum="FF63C12CBC2DDC3E" modified="2016-06-08" version="1">MSSTVEQPIVQVRDACCTLGGRRVLDNVSLDVMRGQVVVLIGPSGAGKTTLLRSLNHLEELDSGEILIAGVPIGHRGLTNRKRVGTAELARRRREIGFVFQHFNLFPHMTAAENVWNAPVRVLGTPKDKALQDAIELLDRVGLAHKADARPSQLSGGQQQRVAIARALAMRPKVMLFDEPTSALDVEMVGEVLAVMRELAKEHMTMVLVTHEMRFARDVADRIVVMDNGRIIEDASPELVFTNPSSDRTRAFLSTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQB7</accession>
    <name>A0A132PQB7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_07510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845981.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22010"/>
    <dbReference type="EnsemblBacteria" id="KWX24526">
        <property type="protein sequence ID" value="KWX24526"/>
        <property type="gene ID" value="AFM11_07510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5350"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="180"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="336"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="407" mass="44339" checksum="7A348CB82135FEFE" modified="2016-06-08" version="1">MQKRHPGFATTVTRELAEATLPDVETLIDRLLSAIFTDNPEWTDYGSVPRDDLREGCRDYLTRVLELLSGRVAGPDPADEVVGAIARHRAEQGVPLEVMLRTFRLGGRIVWEALLERAEQTGVAPDDVLDAGTATWTVIDELSSALSTSYRDSEQERVRHDEQRRNALIEDLLGRRAGDTGFAARVARELELPATGGYLVVVADVRPDGTPALAGPRTVLDALGFRSVWQTKVDTRIGVVALEQRAAADVVACLRPLARGRSAASPAVSGLAEAATAYTLAMIALSMAPSTATELVCLDEHYPEALLVRSPDLAQRLVSRNLGGILDRPAREREVLLETLIVWLEEDRSTANAAVRLHCHRNTVLNRLHRITELVGRPLHGRAAYVELSLALSVLDLPQIGQSAQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQG7</accession>
    <name>A0A132PQG7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoenolpyruvate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846134.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24415"/>
    <dbReference type="EnsemblBacteria" id="KWX24579">
        <property type="protein sequence ID" value="KWX24579"/>
        <property type="gene ID" value="AFM11_07805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5412"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="214"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="1">
        <location>
            <begin position="736"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="813" mass="88785" checksum="B86FEDE3A81449F1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQX6</accession>
    <name>A0A132PQX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08540</name>
        <name evidence="4" type="ORF">AWC31_13825</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846506.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13825"/>
    <dbReference type="EnsemblBacteria" id="KWX24705">
        <property type="protein sequence ID" value="KWX24705"/>
        <property type="gene ID" value="AFM11_08540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18386">
        <property type="protein sequence ID" value="ORX18386"/>
        <property type="gene ID" value="AWC31_13825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5557"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025508">
        <property type="entry name" value="DUF4395"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14340">
        <property type="entry name" value="DUF4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4395" evidence="2">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="160" mass="16508" checksum="4A45B0D3BD09DD40" modified="2016-06-08" version="1">MSSTFTRSPGPTRPDQVDVRGPRFTAWVTTGVLAGILLVAGVDGPAAAVLLAAQAVVFAVGAVAGPRLHPYGKLFATFVAPRLGPVTEREPVPPLKFAQFVGFVFATVGAVGFAFGITALGLVATAFALAAAFLNAAFGICLGCRLYPIVVRLRRTPSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR30</accession>
    <name>A0A132PR30_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846788.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13270"/>
    <dbReference type="EnsemblBacteria" id="KWX24798">
        <property type="protein sequence ID" value="KWX24798"/>
        <property type="gene ID" value="AFM11_09100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5669"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="217" mass="23800" checksum="E79D711DB2DB8FF5" modified="2016-06-08" version="1">MYDLEEAINERHTTRLFLPDKPVPRELVDEALSLAIRAPSNSNVQPWKVLFTSGAARDRLVATLLTQAQAAEPQIPPLPEQFEHHRFEVGAALFGALGIARGDTEARRTVVLRNWEFFRAPLAGIVCMHRDLDYVDAMGVGMFLQTLLLALTARGLDTCVQVSIAGYPDVVRSQLGIGEDLRILCGLGVGYADPDCPANSVHTPRNPLSANVVFIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRB1</accession>
    <name>A0A132PRB1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_09055</name>
        <name evidence="6" type="ORF">AWC31_13315</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13315"/>
    <dbReference type="EnsemblBacteria" id="KWX24863">
        <property type="protein sequence ID" value="KWX24863"/>
        <property type="gene ID" value="AFM11_09055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18300">
        <property type="protein sequence ID" value="ORX18300"/>
        <property type="gene ID" value="AWC31_13315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5661"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX18300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="190" mass="20642" checksum="1EBBC13722655271" modified="2016-06-08" version="1">MRLNRGMTGRPRDTSIDERVLAATRELLVEVGWDDLSVRLVAARAGVGRSSLNRRWSSKAELVLHAIFGESPDMSPFEGTDLTGWIEWVVRGSHELFSRPDLYEAVPGLLLALRENHELRTALWREFSGPAITMFAEQGYGSEADARAALAMAAGAALFVTTVAVDDDSPALQGHLVRLLCSALGASPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS01</accession>
    <name>A0A132PS01_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ORF">AFM11_05895</name>
        <name evidence="10" type="ORF">AWC31_11755</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000002">
        <property type="protein sequence ID" value="ORX19239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845137.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11755"/>
    <dbReference type="EnsemblBacteria" id="KWX24967">
        <property type="protein sequence ID" value="KWX24967"/>
        <property type="gene ID" value="AFM11_05895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19239">
        <property type="protein sequence ID" value="ORX19239"/>
        <property type="gene ID" value="AWC31_11755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4370"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="160"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX19239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="318" mass="33973" checksum="CB1C40CC20807E6A" modified="2016-06-08" version="1">MSARHLLSAADLSRDDATAILDDADRFREALLGREVKKLPTLRGRTIITMFYENSTRTRVSFEVAGKWMSADVINVSASGSSVAKGESLRDTALTLRAAGADALIIRHPASGAAQQLAEWTAEEDGGGPSVINAGDGTHEHPTQALLDALTIRQRLGGIEGKRVVIVGDVLHSRVARSNVTLLATLGAEVVLVAPPTLLPTGVADWPVSVSYDLDAELPAADAVLMLRVQAERMNGAFFPSAREYSVRYGLSEKRQAMLPDRAVVLHPGPMLRGMEIAYPVADSSQSAVLQQVSNGVHVRMAVLFHLLVGADREAISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSE9</accession>
    <name>A0A132PSE9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="8" type="ORF">AFM11_05815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845108.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11675"/>
    <dbReference type="EnsemblBacteria" id="KWX24952">
        <property type="protein sequence ID" value="KWX24952"/>
        <property type="gene ID" value="AFM11_05815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4354"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="160" mass="17162" checksum="2890B4F3C6669888" modified="2016-06-08" version="1">MPDRRGDRGRHQARKRAVDLLFEAEARGLTAEAVADARAALAEDEPDVAPLNPYTVTVARGVTEHAAHIDDLISAHLQGWTLERLPAVDRAILRVAVWELLHAEDVPEPVAVDEAVELAKELSTDESPGFVNGVLGQVMLVTPQIRAAAQAVRGAGTPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSH3</accession>
    <name>A0A132PSH3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845880.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28875"/>
    <dbReference type="EnsemblBacteria" id="KWX25260">
        <property type="protein sequence ID" value="KWX25260"/>
        <property type="gene ID" value="AFM11_06775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4554"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="38"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="388" mass="39942" checksum="8B07A0DEC619F371" modified="2016-06-08" version="1">MTRTGLSPLAWLADVEQQRREAGLRRELRTRPPVGAELDLASNDYLGLSQHPDVLDGGVEALRVWGAGAGGSRLVTGNTELHEGFETALASFVGAESALVFSSGYTANLGALVALSGPGSLVVSDALSHASLVDACRLSRARVTVSAHRDVAAVEAALSARTEERAVVVTESVFSADGVLSPLRELHTACRRHGALLLVDEAHGLGVRGPGGQGLLHEVGLAGAPDVVMTTTLSKALGSQGGVVLGPEAVRAHLIDAARPFIFDTGLAPAAVGAAWAALRVLIAEPQRARAVLAHAAELARIAGVAAQPDSAVVSVILGEPEVAVAAAAACLDRGVRVGCFRPPTVPAGTSRLRLTARASLSREEMDLAGRVLTEVLATARVTDEEPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSI9</accession>
    <name>A0A132PSI9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFM11_06985</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845521.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28665"/>
    <dbReference type="EnsemblBacteria" id="KWX25157">
        <property type="protein sequence ID" value="KWX25157"/>
        <property type="gene ID" value="AFM11_06985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4596"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="3"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="16">
        <location>
            <begin position="354"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KWX25157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="472" mass="50757" checksum="3A8552BFD3B3D245" modified="2016-06-08" version="1">MSRRGKIVCTLGPATGTDETVRALVEAGMDVARLNFSHGDYTDHEAAYKRVRAASDATGHAVGILADLQGPKIRLGRFKDGPTYWATGETVRITVDDCEGTHDRVSTTYKHLAADAAKGDRLLVDDGKVGLVVDQIDGNDVVCTVTEGGPVSNNKGLSLPGMNVSVPALSEKDIDDLEFALRLGVDLIALSFVRSPADIELVHEVMDRVGRRVPVIAKLEKPEAVENLEAIVLAFDAVMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLESMLENSRPTRAEASDVANAVLDGADAVMLSGETSVGKYPLEAVRTMARIIKAVEANSVVVPPLTHVPRTKRGVISYAARDIGERLDAKALVAFTQSGDTVRRLARLHTPLPVLAFTALPEVRSQLALTWGTETFIVPQMKSTDDMIRQVDKSLLDLGRYKRGELVVIVAGAPPGTVGSTNLIHVHRIGEDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSM8</accession>
    <name>A0A132PSM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Ribose-5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_07220</name>
        <name evidence="5" type="ORF">AWC31_17495</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845676.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17495"/>
    <dbReference type="EnsemblBacteria" id="KWX25197">
        <property type="protein sequence ID" value="KWX25197"/>
        <property type="gene ID" value="AFM11_07220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17491">
        <property type="protein sequence ID" value="ORX17491"/>
        <property type="gene ID" value="AWC31_17495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4644"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX17491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="153" mass="16096" checksum="65973A3D8876CBD6" modified="2016-06-08" version="1">MALRIVVGADDAGYEYKEALKGDLAADDRVSEVIDVGVGSDEDTAYPHVAVAAARLVAEGKADRALLVCGTGLGVAISANKVPGIRAVTAHDSFSVERSVLSNNAQVLCFGQRVVGLELARRLAREWLGYEFDPASKSADKVEAICGYESVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTJ7</accession>
    <name>A0A132PTJ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25669">
        <property type="protein sequence ID" value="KWX25669"/>
        <property type="gene ID" value="AFM11_03445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2563"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="78" mass="7866" checksum="3C1D34D0504904DD" modified="2016-06-08" version="1">MGGTAAAAPTEQSVEQTVKSLETSGYHVIVNRTGAAPLSSCTVVGVRQGPTHSTKDSRGGGSINTTVISQTAYVDVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU91</accession>
    <name>A0A132PU91_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cutinase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_00855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842456.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33890"/>
    <dbReference type="EnsemblBacteria" id="KWX25875">
        <property type="protein sequence ID" value="KWX25875"/>
        <property type="gene ID" value="AFM11_00855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.177"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007356435" description="Cutinase" evidence="6">
        <location>
            <begin position="43"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="223" mass="22582" checksum="014EE8FC310457A5" modified="2016-06-08" version="1">MTFDLVRRYTLLVASAVLTATAVLVSPVLASTSVGSLGVASAADCPDVEVVFARGTDEAPGLGRIGNAFVNSLRNKVGGRSVGAYAVNYPASYDFLAAANGANDASAHIQWMVNNCPATRLVLGGYSQGAAVIDVIAAVPFPAVGFNSPLPPNVPEHVAAVAVFGNPSAKLGLPLTASPVYGSRAIDLCNANDPVCTNGDSVPAHRAYEGPADQAASFVAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUC3</accession>
    <name>A0A132PUC3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842453.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25874">
        <property type="protein sequence ID" value="KWX25874"/>
        <property type="gene ID" value="AFM11_00845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.175"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="32067" checksum="9DF7AD9C7C4ED379" modified="2016-06-08" version="1">MDRERPRPFLGSEAIRAELLTAHELRTNHRAVYRNVYLANEGTVTPVLRARAAWLFAGPDAVLSGLSAAAVHGTKWIPVDAPAEVVQDNRHAPDGLRARSYVLAPQDVCEVDGMRVTTMARTAFDLGRFLPHSEAVPILDALMNKTGLDPHDVWSLVKANPGIRGVNRLRESLADADGGAESPLETHTRLTLRCMGVPGLETRIPLYDQWGLVCTHVAMGWPRWKVAVECDEGLNSARHRTWVHAHTAELEERDWSVVWVTASMIFGQNNLREQVWRKLSAAARRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUJ9</accession>
    <name>A0A132PUJ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842985.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26029">
        <property type="protein sequence ID" value="KWX26029"/>
        <property type="gene ID" value="AFM11_01915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.393"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="105" mass="10435" checksum="95FDB34E01CD3A5D" modified="2016-06-08" version="1">MLGAAAAIGWVPVAAAAVAIVYRFPIPFGEYAHGIESAATAALASVFYLVLGGALVVGVLGAAAGATLAKLVPRREGALTVLAGFVIALLGALSLGMLEYVIGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV53</accession>
    <name>A0A132PV53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34350"/>
    <dbReference type="EnsemblBacteria" id="KWX26238">
        <property type="protein sequence ID" value="KWX26238"/>
        <property type="gene ID" value="AFM11_01315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.269"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="281" mass="29101" checksum="1D70612292950642" modified="2016-06-08" version="1">MFGSGPKRSSEANAVVTGAGSGIGAAFASELAARGSRVVCSDIDEEAARRTADAILADGGQATAMHCDVSLIDEVVKLADEAQAWFGGPPSLVINNAGVGAGGKPVGSIELDDWRWVLGINLWGPIHGCHVFTPILRAAGTGQPRGIINVASAAAFGAAPGMAAYNVSKAGTLSLSETLAAELAGTGINVTVLCPTFVKTNIVQSGRITSESSELADRLMRWTGFSAQRVARMCLDTNDRGGLYCMPQPDARIGWGIKRLTPTVYTRAVGLTNRITGSQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVC4</accession>
    <name>A0A132PVC4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26117">
        <property type="protein sequence ID" value="KWX26117"/>
        <property type="gene ID" value="AFM11_02445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.501"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453332" evidence="2">
        <location>
            <begin position="23"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="708" mass="70148" checksum="15A7C1CA8A19AE44" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVF5</accession>
    <name>A0A132PVF5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842925.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34585"/>
    <dbReference type="EnsemblBacteria" id="KWX26012">
        <property type="protein sequence ID" value="KWX26012"/>
        <property type="gene ID" value="AFM11_01805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.371"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="11"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="316"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="407" mass="44160" checksum="796C2F10865A6F04" modified="2016-06-08" version="1">MNTQPNVFTDVFSEAKLGPVTLRNRIIKAATFEASTPNALVTDDLINYHRLPAAGGVGMTTVAYCAVSPGGRTDGWQIWMRPEAIPGLLKLTDAVHAEGAAISAQIGHAGPVANARTNKAQALAPVRFFNPLSMRFAKKATRDDIRDVMEAHANAARLAIDAGFDAVEVHLGHNYLASSFLSPLINRRTDEFGGSLENRAKVARGVVRAVRQAVDAYAPGQIAVTAKLNMSDGVRGGISTEESLQTAKWLEEDGALDAIELTAGSSLVNPMYLFRGDAPVKEFAGAFKPPIRWGVRMMGKNFLRQYPYREAYLLRDAKLFRAELKMPLILLGGITNRDTMDLAMAEGFEFVAMGRALLAEPDLINRIKADGEAHSIKSLCTHCNRCMPTIYSHTHCVVTGAPDALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVG0</accession>
    <name>A0A132PVG0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843672.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34500"/>
    <dbReference type="EnsemblBacteria" id="KWX26264">
        <property type="protein sequence ID" value="KWX26264"/>
        <property type="gene ID" value="AFM11_01750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.360"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019966">
        <property type="entry name" value="F420-dep_enz_PPOX_Rv3369"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03667">
        <property type="entry name" value="Rv3369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="137" mass="14874" checksum="F5C6B1390BB52B0A" modified="2016-06-08" version="1">MSTELTPEVSQRLTSDHYGWLTTVAKSGQPVPRLVWFYFDGTDIVVYTMPGAAKVRHITAQPRVSLNLDSDGNGAGIIAIGGTASVDATDSDPRGDEAYWAKYSADAEKFGLTEAMAAYNTRLRISIDKVWTTPTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAR6</accession>
    <name>A0A132PAR6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000062">
        <property type="protein sequence ID" value="KWX19416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19416">
        <property type="protein sequence ID" value="KWX19416"/>
        <property type="gene ID" value="AFM11_35985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="102"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="451" mass="46198" checksum="745AD4FE3B449367" modified="2016-06-08" version="1" fragment="single">TARMDLSFSLGERWTADGQPAGIGGAVEFRTDVFDAATIERLIARLEQVLATVADEPAQRISHIDVVTADEHAHLDDHGNVGVLTAPAPGLSSIPVLFGGQVLRCPDAVAVSCGRRSMTYAELDEASDRLAHLLVGHGAGPGRRVAVLFSRSVEAIVAIVGVLKSGAAYVPIDPALPDARVGFVLGDAAPVAVVTTAQLRPRVEGYDLLVVEVDDARLGDQPSGVLPVPAADDVAYVIYTSGTTGVPKGVAVTHGNVAQLVESLPVDLPRAGAWTQWHSYSFDVSVWDIFAPLLGGGRVVVVPEEVAASPADFHALLVAEGVDVLSQTPSAAAMVSPQGLGSMALVVAGEACPADLVDRWAPGRAMFNAYGPTEATVYTAVSAPLVAGCGVVPIGSPVPGSALFVLDGFLRPVPPGVVGELYVAGGGLAVGYVGRSGLTGSRFVACPFGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAW4</accession>
    <name>A0A132PAW4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_36030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000071">
        <property type="protein sequence ID" value="KWX19407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19407">
        <property type="protein sequence ID" value="KWX19407"/>
        <property type="gene ID" value="AFM11_36030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="104"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="227" mass="24290" checksum="27D19C805823CA00" modified="2016-06-08" version="1" fragment="single">DTQTARMDLTFSLNERWTDDGAPAGISGAVEFRTDVFDPTTIQQLVTRLERILVAVTADPLRRLSSVELLSEDERERLDAWGNRNAPIMSEVAAKSIPVLFGGQVARCPDAVALVSDGRSVTYRELDEASNRLAHLLVGHGAGPGRRVAVLFSRSVEAIVAILGVLKTGAAYVPIDPAHPDARVGFVLGDAAPVAVVTTAQLRPRVEGYDLLVVEVDDARLGDQPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBK0</accession>
    <name>A0A132PBK0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_34200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859133.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19700">
        <property type="protein sequence ID" value="KWX19700"/>
        <property type="gene ID" value="AFM11_34200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5178"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="217" mass="23445" checksum="0C856AC011C06F8C" modified="2016-06-08" version="1">MVTVFLVDDHELVRRGLIDLVSADPELEVIGEAASVSEATARVPALKPDVAVLDVRLPDGNGIELCRELLSRLPGLRCLMLTSFTSDEAMLDAILAGASGYVIKDIKGMDLTNAIKEVGAGRSLLDNRAAAALMGKLREAAEHSDPLSGLSSQEKVLLELVGEGLTNKQIAARMFLAERTVKNYVSRLLAKLGMERRTQAAVFVSKLDQSRHHSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBK1</accession>
    <name>A0A132PBK1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_34660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859386.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22230"/>
    <dbReference type="EnsemblBacteria" id="KWX19696">
        <property type="protein sequence ID" value="KWX19696"/>
        <property type="gene ID" value="AFM11_34660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5279"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="70"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="253" mass="26555" checksum="748C0638A7009582" modified="2016-06-08" version="1">MTEKSGGVQSVERAFELMELIGRAGGECSLTELSAESPLPPPTIHRLLRTLVGLGYVRQLPNRRYALGPRLIRLGVVANRQLGAVAAPVLQSLVDELSETASLAVLDGDMVIYTGQVLPPTLMGTDSEVGKRVGLHTTGVGKAVLAELDDARILKLVTQSGFPAPTENSASTLSAVFANVERVRVDGYAVDNEEFEIGVRSVAMAVPGAPTPMAIGISGPSAHVSEELITRAVPALKKATGVISEALIGARER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBP6</accession>
    <name>A0A132PBP6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11260"/>
    <dbReference type="EnsemblBacteria" id="KWX19749">
        <property type="protein sequence ID" value="KWX19749"/>
        <property type="gene ID" value="AFM11_34410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5226"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="40"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="294" mass="31932" checksum="9F9C83081906D301" modified="2016-06-08" version="1">MTDDHGHDGLFEHSGTELGLTGRPPRDIPEPQPRSTHGPAKVIAMCNQKGGVGKTTSTINLGASLAEYGRRVLLVDLDPQGALSAGLGVPHYELAHTVHNLLVEPRVSIDDVLIKTRVSGMDLVPSNIDLSAAEIQLVNEVGREQSLARALYPVLDRYDYVLIDCQPSLGLLTVNGLACADGVIIPTECEYFSLRGLALLTDTVDKVHDRLNPKLSISGILVTRYDPRTVNAREVMARVVERFGDLVFDTVITRTVRFPETSVAGEPITTWAPKSGGAIAYRSLAREVIYRFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBX0</accession>
    <name>A0A132PBX0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19747">
        <property type="protein sequence ID" value="KWX19747"/>
        <property type="gene ID" value="AFM11_34355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5216"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="68" mass="7039" checksum="286306E158A459B4" modified="2016-06-08" version="1">MKNPTPTPVQRKLCTVGDVCGQLSVGRTTVYGLIADGTLRRVKVGARALIPQSDVDAFVAGLLDGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC56</accession>
    <name>A0A132PC56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858768.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02180"/>
    <dbReference type="EnsemblBacteria" id="KWX19909">
        <property type="protein sequence ID" value="KWX19909"/>
        <property type="gene ID" value="AFM11_33570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5047"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="174" mass="19372" checksum="B15A0B1DF9B0E265" modified="2016-06-08" version="1">MPTVETLTGPRLTLRAPVVDDAEALFARIASDPEVTRYLSWRPHPDVAETRRVITSLFNVGAERTWLIEIGGEVVGLCGSRRVQPHAVELGYCLARSYWRQGLMTEAVSMVLDEERRDPSVYRVSAYCHVDNAGSAGVLRRCGLSLEGRLARYAVFPNISEEPQDVLLFGKAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD22</accession>
    <name>A0A132PD22_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857456.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25495"/>
    <dbReference type="EnsemblBacteria" id="KWX20235">
        <property type="protein sequence ID" value="KWX20235"/>
        <property type="gene ID" value="AFM11_31340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4174"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="383" mass="41688" checksum="1959D2C7C3EAB026" modified="2016-06-08" version="1">MSDLCTPTFADLATRLGFSCDTAGGLVEFRNPFGLENWTLPVLELTVIVGAVLALVYAITRLRRHNDPTNLVLWFGAIAYLLIIEPPLYFPGAFGISEYVDTMFAHNVFTVDFLWGRLPLYIVAIYPMMATVAFEIVRTLGVFRRYGALVGAVCVGFVHHAFYEIFDHLGPQLRWWEWTLDHPMNQPFFDSVPLPSVVVFAALWPMSLAFCVQIFVGRYVDEGKTFTGPQLLWRTIVVGVLASIGTAVLPMPATIGAAISGSTTVGGFIYAAELVVLSVVAIPVLIRQWSAVRHQPTEPYSNPLILRYAVVYLGVMAVLWATALPGYFGAVDGVTADGDPIGSLWYTVACLVIAALSIAAAATATNAARRDCTEIATVGENAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD96</accession>
    <name>A0A132PD96_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_31610</name>
        <name evidence="7" type="ORF">AWC31_26225</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX15089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857697.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26225"/>
    <dbReference type="EnsemblBacteria" id="KWX20313">
        <property type="protein sequence ID" value="KWX20313"/>
        <property type="gene ID" value="AFM11_31610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15089">
        <property type="protein sequence ID" value="ORX15089"/>
        <property type="gene ID" value="AWC31_26225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4226"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX15089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="150" mass="16254" checksum="67D72DBDC6BF5106" modified="2016-06-08" version="1">MKVFNNLDELVAAAGSELGPTDWMEITQDRVNLFADATDDHQWIHVDPDKAAGGPFGGTIAHGLLTLSLLPHFTHQLYRVDNVTMAINYGYNKVRFITPVRVGAKVRARAHIADVAKLDGAVQATMTVTVEIDGSDKPAAVAESIIRFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDE4</accession>
    <name>A0A132PDE4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857119.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26470"/>
    <dbReference type="EnsemblBacteria" id="KWX20336">
        <property type="protein sequence ID" value="KWX20336"/>
        <property type="gene ID" value="AFM11_30750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4052"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="364" mass="39030" checksum="3F79C7D796DFF540" modified="2016-06-08" version="1">MRRAGQIVWELGGVVPRSVAALRNSRDWNALSLCGLRQLGEVALDELVVTGMTLTGPPPQLPRPLADYEAAADELAPLGIDGAHVSPEPLEITDIRRATFGSLKFEELTFEHEPHLPASVLADGHGGVATARARLYRSGDDTRPWLIWVHGAGQGDAMDLMVARARRLQAQLGFNVALPVQPGHGVRRRSWPEYPARDPLANVAGMMRAVSEVRALIGWLAPQSTAIALGGLSLGSAVAALVSHLDDRVGAVAVYTPILGLNTMIGMHLGRWGRAGREAGALLQSDTIAALTSVVDPLRTVPQTERRLIIGAWHDRMAMRDSALALHERWGGELHWHDGSHVGHLFSAGVCAATERFLGSSAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDH5</accession>
    <name>A0A132PDH5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857198.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26650"/>
    <dbReference type="EnsemblBacteria" id="KWX20366">
        <property type="protein sequence ID" value="KWX20366"/>
        <property type="gene ID" value="AFM11_30930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4088"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="31834" checksum="EE17734451AA11A7" modified="2016-06-08" version="1">MAQGSDVREHFRGKRCFVTGAASGIGRATALALAAHGAELYLTDRDDEGLAQTVADARALGAQVPEHRVLDISDYDEVAAFAKDIHAAHAPMDVVMNIAGVSAWGTVDRLSHEQWRSMIDINLMGPIHVIETFLPPMVEARRGGHLVNVSSAAGLVALPWHSAYSASKYGLRGLSEVLRFDLARHRIGVSVVVPGAVKTGLVQTVQIAGVDREDPNVQKWVDRFAGHAISPEKAAAKILAGVRRNRFLIYTSSDIRALYTFKRVAWWPYSVAMRQVNVLFSRALRPKPVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDT3</accession>
    <name>A0A132PDT3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_32515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858229.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19650"/>
    <dbReference type="EnsemblBacteria" id="KWX20122">
        <property type="protein sequence ID" value="KWX20122"/>
        <property type="gene ID" value="AFM11_32515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4832"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="9">
        <location>
            <begin position="124"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX20122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="249" mass="27094" checksum="71890D68BDF54F2B" modified="2016-06-08" version="1">MQQRRLDNWEHRAEWPLAAVAAVFLAAYTIEVLVQPHGLAARAINMATLLTWAVFTADYVARLYLAPDRKQWFVTHLFDLMIVLLPLLRPLRLLRLIVLISVLQKAVGNAIRGKVVLYTISGAVLLVYVASLAVLQAERGAPDAHITDFGDAVWWAITTITTVGYGDMYPVTTTGRVIAALLMIGGISLVGSITATIASWIVQSVTVDETATAAATAAHINQLRAEIASLREELRGAPVIDGSGHQYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDW3</accession>
    <name>A0A132PDW3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vanillate O-demethylase oxidoreductase VanB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857360.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26930"/>
    <dbReference type="EnsemblBacteria" id="KWX20417">
        <property type="protein sequence ID" value="KWX20417"/>
        <property type="gene ID" value="AFM11_31220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4149"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="164" mass="18331" checksum="0E74DB1ECDC758C6" modified="2016-06-08" version="1">MSTDRIEKEVLLRAPLDRVWRAISDADEFGRWFGVRFDGPFVAGTSVTGVITPTEMDEEVAAMQEPYTGQADTWQIVAVEAPHRLAFRWHPYAVDQDSDYSAEPTTLVEFSLSEAADGVLLRIVESGFDAIPAERRASAFEANSDGWAHQTELVRKYLALHESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE00</accession>
    <name>A0A132PE00_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exonuclease SbcC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856478.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24975"/>
    <dbReference type="EnsemblBacteria" id="KWX20566">
        <property type="protein sequence ID" value="KWX20566"/>
        <property type="gene ID" value="AFM11_29635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3819"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="180" mass="18682" checksum="2AB36B36BCE1E9EB" modified="2016-06-08" version="1">MTSDATDIVLSVPDLRAVTAFAAGCAEVALEIFQADRPDDTRPRAAIEAAWEFARGGRRGKALRDTAWAALRAAKETDDAAAREAAMAAMCAAGAAYLHPLAKASQVKHIVGAGAFAARAAELVAGGDPAVGAAHLDEAAKRATPTVVAVLRRFPRAPDGGGRVGELMRQLDSQLRRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE27</accession>
    <name>A0A132PE27_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856523.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25055"/>
    <dbReference type="EnsemblBacteria" id="KWX20581">
        <property type="protein sequence ID" value="KWX20581"/>
        <property type="gene ID" value="AFM11_29715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3835"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="393" mass="40965" checksum="281C9E31041C4CD1" modified="2016-06-08" version="1">MNARTHVVVIGGGYAGTLAANRLQQNSDIDITLVNPRPRFVQRLRLHQFAAGTGDATADYGALLGRRVDLVVDNADRIDASARTVHLTSGRALTYDYLVYAVGSTGATPATVPGAAEFAYPIAELEHAARLRSAIADLGPDAWITVVGGGLTGIETAAELAEQGHKVILACGGRLAPSFSEPARRSVADWLTKHGVGVVESGVVAEVRPDSVVLADGTDLPSAVTVWTAGFGVPDLAVRSGLRTDPLGRLLTDETLTSVDDDRIVAAGDAVAPSGQPLRMSCYTAGPTAATAADTVLSRIAGVEPGLLSLAYMATNVGLGRRAAHFQLTRKDDTPVNIYLGGRIGSRIAGSLKEAVTKGTLWGIRREARKPGSTVWPKGGTRPAIAELDSLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE44</accession>
    <name>A0A132PE44_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856582.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25185"/>
    <dbReference type="EnsemblBacteria" id="KWX20600">
        <property type="protein sequence ID" value="KWX20600"/>
        <property type="gene ID" value="AFM11_29845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3861"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="147"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="251" mass="26847" checksum="5054EEDB74D1F029" modified="2016-06-08" version="1">MQTESMSALPQTCYPAVWLWPGQALYSGPGLGLEPHSGSVWCLAVGVDAPLTVIVDGETVVARTVLIPPRLTHHLVMTGPLVSCYLDPASHRAASCRQQFDATHHGIGVGHRAEDLLLVPPDDDGAALRWLDTAAPSAVHAIDPRIEVAAKQIREDPAADVSARELAATVGLSESRFLHLFRQEVGSSLRRYRLWSRLLRAGAEIAAGRNLTTAAVEAGFASPSHLADRFKTTFGLSATQLLATGLTVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PED4</accession>
    <name>A0A132PED4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040148.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20699">
        <property type="protein sequence ID" value="KWX20699"/>
        <property type="gene ID" value="AFM11_29215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3728"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="227" mass="24140" checksum="8962E737F1FE6509" modified="2016-06-08" version="1">MADDADTTGQLRTAGRTSTLMPDERAASAPIGAEPTHGGDAGTAEDASSGPDGKDTHTAPPGEPRTTRSPLRAAMLVGVAVVIALATLAGWLGFRLHHLHEAQTERNAYVQVGRQAALNLTTIDWQNADADVRRIIDGATGQFYDDFTKRSQPFIAVVKQTKSTTIGTVTEAALESKTAGTAQVLVAVTVKTTNAAVPDQRPRAWRMRIFVQQVGDQPKVSNVEFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEH6</accession>
    <name>A0A132PEH6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">benD</name>
        <name evidence="2" type="ORF">AFM11_31010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.25" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857241.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26720"/>
    <dbReference type="EnsemblBacteria" id="KWX20382">
        <property type="protein sequence ID" value="KWX20382"/>
        <property type="gene ID" value="AFM11_31010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4105"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047116">
        <property type="term" value="F:1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="26928" checksum="88A708FAC10A9AF0" modified="2016-06-08" version="1">MRFTGKVAVVTGAAQGIGKGVACGIAAEGGAVVLADRSDHVHGASDEISSAGSAARGFVCDLETYSGACDLIQFAIAEFGRIDILVNNVGGTIWRKPYEFYEEHQILAELHRSLLPTLWCARAALPSMIERGHGVIVNVSSNATRSINRVPYAAAKGGVNALTASLAFEAASKGIRVVATAPGGTAAPPGGIPRNPDPLTDDEIRWHEETVVQSTQSTFLKRYSSIEEQVAPILFMASDDASYITGTVLEVSGGDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PES3</accession>
    <name>A0A132PES3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20835">
        <property type="protein sequence ID" value="KWX20835"/>
        <property type="gene ID" value="AFM11_28845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="79" mass="8401" checksum="6C2B710C77C4439A" modified="2016-06-08" version="1">MAVDDPGVDEIVQMADEHAFGDLGDAAPQLGGAHRPVDQAPQDGAFPAAVDDRQRGVDRTFADFFLRHRHGVAPHVGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEY4</accession>
    <name>A0A132PEY4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_27795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855710.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10325"/>
    <dbReference type="EnsemblBacteria" id="KWX20896">
        <property type="protein sequence ID" value="KWX20896"/>
        <property type="gene ID" value="AFM11_27795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3433"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="7">
        <location>
            <begin position="51"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="8">
        <location>
            <begin position="321"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="530" mass="54848" checksum="30FD901DA8FB1919" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF14</accession>
    <name>A0A132PF14_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855605.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10100"/>
    <dbReference type="EnsemblBacteria" id="KWX20864">
        <property type="protein sequence ID" value="KWX20864"/>
        <property type="gene ID" value="AFM11_27570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3388"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="133" mass="14509" checksum="4428C70D11445D2C" modified="2016-06-08" version="1">MTIFVIDAAVAIDLAAGGATIPPEHSLAAPTLLRSQALALVYESVHRGEIDERTGRKVLDDIRGLRIRLLGDRVLQHHAWQIADKLNWPDTYQAEYIALTQLQADALATADEKLAAAARTLVKTVPPAEILRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF48</accession>
    <name>A0A132PF48_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855929.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10825"/>
    <dbReference type="EnsemblBacteria" id="KWX20966">
        <property type="protein sequence ID" value="KWX20966"/>
        <property type="gene ID" value="AFM11_28275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3529"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040701">
        <property type="entry name" value="Bact_RF_family2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18844">
        <property type="entry name" value="baeRF_family2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="372" mass="38906" checksum="21B5D2CE89D7BFF8" modified="2016-06-08" version="1">MHSEHFRTLLTATGPYGSIYFDDSHDTEDAAAQTDLKWRGMAEELARQGAGPDLIDRLAEAVTASPAPVGRGGRVVVANADGVLVDERVSRADGPPVVRVSELPYIVPVLAHGVEQPTYLVAIVDHAGADIELHRDGTVTTHTVEGEGYPVHKASGAETPGYGDPQPRTEESRSKNIRAAADRVTAIVDEEAPELVFVVGEVQSRSDFAAALPDRVSERLVQLQVGARHSGFDREHLHDAIGEHLQRRHADAINAAAQRFSAELGRHSGMATEGLNGVCAALREGAVETLIVGSIGDATVVASDDLATVAPNANVLSELGAAPTHTLRADEALPLAAVSIGAELIGAAEGQSPADGVAAVLRYAPRTAATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF85</accession>
    <name>A0A132PF85_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856010.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10510"/>
    <dbReference type="EnsemblBacteria" id="KWX20990">
        <property type="protein sequence ID" value="KWX20990"/>
        <property type="gene ID" value="AFM11_27990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3472"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="36"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="217" mass="24145" checksum="733F2AFE2244E5E6" modified="2016-06-08" version="1">MTVPMTDSIAGIEVPDTALVREVTEYIRDAEDDLLFHHSRRVFFFGALQGMRRGLQPDLELLYVGAMFHDLGLTEPYRSSSTLRFEVDGANAARDFLLQRGVDAAAARKVWLGIALHTTPGVPEFLDPEIALVTAGVETDVLGIGRDDLTPDALAAVTAVHPRPDFKNRILRAFNDGVRQRPHSTFGTVNDDVLAHFDSSFVREDFVEVIRQNSWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFU7</accession>
    <name>A0A132PFU7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854933.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21200">
        <property type="protein sequence ID" value="KWX21200"/>
        <property type="gene ID" value="AFM11_26460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3161"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="160" mass="17298" checksum="2245CF243390E67B" modified="2016-06-08" version="1">MGDSWSDTSWDDDEADSSEDESTLSALDYINDGEEPSSTSETEADVEDSGLEMLFTVTNPPGTVSVTTLVNGLPMQIDLAPRVVDMTENELTEEILLIARLAAQNALAGQHVLISGIMQRCGLDPSAVRSYLEHDLGLPSAEKVLAEKAQIFAERYGYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFX7</accession>
    <name>A0A132PFX7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855037.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22675"/>
    <dbReference type="EnsemblBacteria" id="KWX21235">
        <property type="protein sequence ID" value="KWX21235"/>
        <property type="gene ID" value="AFM11_26660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3203"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026004">
        <property type="entry name" value="Septum_form"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13845">
        <property type="entry name" value="Septum_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septum_form" evidence="2">
        <location>
            <begin position="88"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="484" mass="49980" checksum="C2468BF98B1F04F0" modified="2016-06-08" version="1">MERMLEAPEHPDRLPDRTDGDPHEGRWWQSLQAASTRRALLLTALGGLLIAGLITALPRSEGAQTALNAGAISLGPRGNDTFDHVKSGDCLNWPGRNPDAAHIVDCKDPHRFEVAESIDMRTFPGSEYGPGAAPPSVDRIKQISQEQCSPALKSYLGPKFDPNGKFTIGLLWSGEKAWKQSGERRMLCGLQLLGPGDSQLEFQGKVADIDQSKVWPAGTCLGIDPATNQPTDVPVDCAAPHAMEVTGAVNLAEKFPGGLPAEADQDEFIKDTCTKLTDAYLAPVQLRATTLALSYSTISLPSWSAGSHQVSCSIGATLGNGGWSTLVNSAKGPLMINGQPPVAPPDIPEERLNLPPIPMPESDSSSSSDSSDSSYGSSSSSGSSSSGSSPDSSSDSSGSSSSSQSEHMPQQSAPSTTAEPAPPAQSNTFNPPPPGAPPAPAPPPAPEQAPTPPAPAPAPAPAPAPPAGPPPGEPVLPPPPPPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFY9</accession>
    <name>A0A132PFY9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Superoxide dismutase</fullName>
            <ecNumber evidence="4 8">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_26600</name>
        <name evidence="12" type="ORF">AWC31_22735</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4 8"/>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855005.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22735"/>
    <dbReference type="EnsemblBacteria" id="KWX21223">
        <property type="protein sequence ID" value="KWX21223"/>
        <property type="gene ID" value="AFM11_26600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15408">
        <property type="protein sequence ID" value="ORX15408"/>
        <property type="gene ID" value="AWC31_22735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3190"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="10">
        <location>
            <begin position="91"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX21223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX15408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="207" mass="22908" checksum="5192009F711E8BA2" modified="2016-06-08" version="1">MAEYTLPDLDYDYGALEPHISGQINELHHSKHHATYVKGVNDAVAKLEEARANGDHAAIFLNEKNLAFHLGGHINHSIWWKNLSPNGGDKPTGDLAAAIDDQFGSFDKFQAQFTAAANGLQGSGWAVLGYDSLGGRLLTFQLYDQQANVPLGIIPLLQVDMWEHAFYLQYKNVKADYVKAFWNVVNWEDVQNRYAAATSKTGGLIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG20</accession>
    <name>A0A132PG20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854792.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21157">
        <property type="protein sequence ID" value="KWX21157"/>
        <property type="gene ID" value="AFM11_26200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3106"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="170" mass="17980" checksum="8736DEEAD3E0AD29" modified="2016-06-08" version="1">MSEREAGGSFDYLWDDPPPTPDAGPNAGRDGFDAFDINTWNFKPAPVPWYRTRGAAIALIAAGVAAAAIVVSLVLLLLRGSSPVVDEDEPTSVAPTATTAPPSPSPSLRVGVPPAPPPPPPPPAQEAPRRPVYRPTQRPSENKKPEIGVTRTPVTRSPISVAPQPRHPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG32</accession>
    <name>A0A132PG32_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-hydroxy-3-carboxy-6-oxo-7-methylocta-2, 4-dienoate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854377.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24810"/>
    <dbReference type="EnsemblBacteria" id="KWX21285">
        <property type="protein sequence ID" value="KWX21285"/>
        <property type="gene ID" value="AFM11_25470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2956"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="323" mass="34242" checksum="9AE33317D4EFF763" modified="2016-06-08" version="1">MSVDVHAHWLPEELFSLPPGSPVPPLNGRDGQLHLGELPLSIETAAMSDADRVLADTDAAGLASRVLSAPPFAFPVADAPGVAEYVGSFNEHVARVCRDSDGRLLGLGLVSLHDPAAAAAQMDAIKHSELLRGIAVPPLLGATSFDSGPLREVVEIAADRRLAVLVHPMQLPRPEWSSYYLANLIGNPTETATAAAALVLGGVLDKLPDLRICLLHGGGCAPALLGRWQHGWQQRADVRSGGGRPPVEGFAGLWFDTLTHDGPTLELLRAHADPSHLMCGSDYPFDMGVARPLELPRAAGLTDDLLARNARRFLGLDEGETHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG91</accession>
    <name>A0A132PG91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Benzene 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_25805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854532.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36090"/>
    <dbReference type="EnsemblBacteria" id="KWX21340">
        <property type="protein sequence ID" value="KWX21340"/>
        <property type="gene ID" value="AFM11_25805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3025"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017639">
        <property type="entry name" value="Benzo_1-2-diOase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03229">
        <property type="entry name" value="benzo_1_2_benA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="49"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="451" mass="50607" checksum="0F2D09261C2D831C" modified="2016-06-08" version="1">MTATHLASVLADAVIDDPAAGIYRANRRIFTDDEIFELEMKHIFEGNWIYLAHESQLPNPGDYFTTYIGRQPVVITRDKDGQLHCLINACAHRGAMICRRKTDNRTTLTCPFHGWTFRNDGTLLKVKDPEGAGYPNTFNVNGSHNMTKVARFDNYRGFLFGSLDADVLPLTEHLGDATTVIDMLVDQSPEGLEVLRGSSTYTYDGNWKVQAENGADGYHVTATHWNYAATTSRRNTGESKNDTKALDAGGWGKSGGGYWSFPHGHLCLWTWAANPQDRPLWDKLDELKAQFGQAKGEFMVKGSRNLCVYPNVYVMDQFSTQIRHFRPIAPDKTEVTIYCIAPKGESDEARAHRIRQYEDFFNASGMATPDDLEEFRSCQLTFRAQAAPWNDMSRGAEHWLSGPDPLAESLGMTGIVSAGIRNEDEGLYPVQHGYWLQTMRQALADEEGAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGD7</accession>
    <name>A0A132PGD7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactopyranose mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855159.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22620"/>
    <dbReference type="EnsemblBacteria" id="KWX21277">
        <property type="protein sequence ID" value="KWX21277"/>
        <property type="gene ID" value="AFM11_26715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3214"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004379">
        <property type="entry name" value="UDP-GALP_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015899">
        <property type="entry name" value="UDP-GalPyranose_mutase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03275">
        <property type="entry name" value="GLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00031">
        <property type="entry name" value="UDP-GALP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLF" evidence="4">
        <location>
            <begin position="153"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="397" mass="45503" checksum="1F2F4B6312C642BE" modified="2016-06-08" version="1">MTARFDLYVVGSGFFGLTIAERVATQLDKRVLVIERRPHIGGNAYSEADPQTGIEVHKYGAHLFHTSNKRVWDYVRQFTDFTGYQHRVFGMHKGQAYPLPMGLGLVSQFFGRYFTPDEARALIAEQSSEIKTEDAQNLEEKAISLIGRPLYEAFIKHYTAKQWQTDPKELPAANITRLPVRYTFDNRYFNDTYEGLPAGGYTAWLQNMAADDRIEVRLDTDWFDVRDTLRAENPDAPVVYTGPLDRYFDYAEGRLGWRTLDFEVEVLDTGDFQGTPVMNYNDIEVPYTRIHEFRHFHPERAYPTDKTVIMREFSRFAADDDEPYYPINTEADRKLLAAYRARAKAETASAKVLFGGRLGTYQYLDMHMAIASALSMYDNTLAPHLSDGAPLITDPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGI7</accession>
    <name>A0A132PGI7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">DNA ligase</fullName>
            <ecNumber evidence="9 10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ligA</name>
        <name evidence="13" type="ORF">AFM11_24700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="9 10"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853960.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26955"/>
    <dbReference type="EnsemblBacteria" id="KWX21423">
        <property type="protein sequence ID" value="KWX21423"/>
        <property type="gene ID" value="AFM11_24700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2301"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="618"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="49"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX21423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="703" mass="76144" checksum="61189441994B646F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGJ9</accession>
    <name>A0A132PGJ9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="3 6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">IPP:DMAPP isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">idi</name>
        <name evidence="9" type="ORF">AFM11_24860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3 6"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854044.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27115"/>
    <dbReference type="EnsemblBacteria" id="KWX21451">
        <property type="protein sequence ID" value="KWX21451"/>
        <property type="gene ID" value="AFM11_24860"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR018427-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="182" mass="19941" checksum="DB18F3E1A81C8361" modified="2016-06-08" version="1">MAVSTTDELVVLLDEDGAAIGCARKATVHHRDTPLHLGFSCYLFDDDGRVLLTRRALGKRTWPGVWTNSFCGHPAPDEELSDAVARRARQELGVAIDSPTCVLPDFRYRAVAPDGTVENEICPVFWARVDGTVAPAADETMDVRWVSWQDLRTAAALAWAISPWAAEQVPLLERAGLVDQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGP0</accession>
    <name>A0A132PGP0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_26230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854815.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23370"/>
    <dbReference type="EnsemblBacteria" id="KWX21162">
        <property type="protein sequence ID" value="KWX21162"/>
        <property type="gene ID" value="AFM11_26230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3112"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="41"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="3">
        <location>
            <begin position="193"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="275" mass="28715" checksum="682A510FAD8A7875" modified="2016-06-08" version="1">MALRDSRGTRRPRDHGDPGDAPSAPPPLTPVGDAARPSAAEEARTIVASTNTGTLATLTEDGDPWASFVTYGLLGGSPVLCVSNLAEHGRNLASDPRASIAIVAPKTESDPLASGRVTLAGMAERPAGDELAAARDAHLAAVAAAKYYIDYSDFSVWVLRVHRVRWVGGYGRMDSATGADYAAAEPDPVTPRSAGAIEHLNADHADSLTAMARTLGGYPDTTAAVCTGADRYGLDLRVTTDRGIAYTRVGYAAPIGSYDELRGATVELARRARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGW5</accession>
    <name>A0A132PGW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853493.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21589">
        <property type="protein sequence ID" value="KWX21589"/>
        <property type="gene ID" value="AFM11_23925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2143"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="323" mass="34849" checksum="E592F33EF27F2888" modified="2016-06-08" version="1">MDLDGVRTFVAAADLGQFQAAADELGLTPQAVSKRVAALEHDIGAVLFTRTPHGVRLTSDGQTFLPHAQDLLGAAERARQSVRPEARPLRVDVPHRRVAPSVVLQDFHVAHPELDVEVVTLPNNTLAGALTAVHSGSVDASFRAVTMPAADMPDGLTAARAIDHELELLVGPKHPLAGRTSIDPRDVAGHRIWIPGIAPGTEWAAFYSELADAFGLTIDGRGPHFGDEALLETLCQATDIATVVGKRDRYLWPSWYELRRIPLRNPTPVYPHSLVWLSANPHPGLATLRNYLGALHKPGCHEPDVWLPSWADAATGSLAETDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH30</accession>
    <name>A0A132PH30_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25585</name>
        <name evidence="3" type="ORF">AWC31_24695</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854426.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24695"/>
    <dbReference type="EnsemblBacteria" id="KWX21302">
        <property type="protein sequence ID" value="KWX21302"/>
        <property type="gene ID" value="AFM11_25585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14412">
        <property type="protein sequence ID" value="ORX14412"/>
        <property type="gene ID" value="AWC31_24695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2980"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX14412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="129" mass="13851" checksum="45CE7BD4F8EBEA84" modified="2016-06-08" version="1">MTAPSPQQISVAPTARRLSGLLLGMGVLHFVAPKPFDSIIPAELPGSARFYTYASGVGELATGALLAAPRTRRLGALAAVALFVAVFPGNVNMVRLWWDKPWPMRIGAIARLPLQIPMITTALKVYRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH98</accession>
    <name>A0A132PH98_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853674.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23835"/>
    <dbReference type="EnsemblBacteria" id="KWX21644">
        <property type="protein sequence ID" value="KWX21644"/>
        <property type="gene ID" value="AFM11_24280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2215"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453247" evidence="2">
        <location>
            <begin position="36"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="227" mass="23895" checksum="7599F568C66756EB" modified="2016-06-08" version="1">MTLRRKLLVFSAPVALLLVIAVLKLVSVGVAGRSAVSNFADRDAEAMAGDVAVLRVLNVVEPARAYYADGARAVLENRLEDADRQFSEALARTDLSQSCPVRVNLVLVRETLGDRAAGVFDSETAAARYLAAKAVVEQAPDGCFAGNDDPDPQRQAVRADALARLDRKIEAVRAIPPPPPPPPPAAAPVAPPPTSGGGAPDRSENRLDPGTGDPLERLQEILRDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHJ5</accession>
    <name>A0A132PHJ5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxynitrite isomerase</fullName>
            <ecNumber evidence="5">5.99.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ferric nitrobindin</fullName>
            <shortName evidence="5">Nb(III)</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_24515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="5">Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Nitrogen metabolism.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.99.-.-" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853776.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23605"/>
    <dbReference type="EnsemblBacteria" id="KWX21677">
        <property type="protein sequence ID" value="KWX21677"/>
        <property type="gene ID" value="AFM11_24515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2264"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062213">
        <property type="term" value="F:peroxynitrite isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01297">
        <property type="entry name" value="nitrobindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022939">
        <property type="entry name" value="Nb(III)_bact/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="PTHR15854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="6">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXWXGXG" evidence="5">
        <location>
            <begin position="16"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="17566" checksum="64A109C196CCD873" modified="2016-06-08" version="1">MVDLHPGIAVLAPLLGTWAGPGAGEYPTIEPFEYLEEITFGHVGKPFLTYSQRTRARDDGRPLHAETGYVRVPEPDRLEWVLAHPTGITEIQEGTLTTDGDHISMDLTATTIGLTESAKKVTALARSVRVEGDELTYTVRMGAVGQPLQHHLAATLTRKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHK3</accession>
    <name>A0A132PHK3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21783">
        <property type="protein sequence ID" value="KWX21783"/>
        <property type="gene ID" value="AFM11_23300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2015"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="239" mass="26043" checksum="985E1FA5A5E01F30" modified="2016-06-08" version="1">MSDVPNDDSNENPSISEPVKVVKFAEEWWLARNNAGRCTAHRRNGNRCQKPAMEGQRVCGTHGGRAPHAKRAARRRLEEASQMLAKELLKMATDDDVSDAVKLNAIKDALDRGGLKAPTQVELEVGPPRPYEQILAGIAPMTRAESRARRGLTDSTPALPGGVSRNAPAPDGEIVDAEIVPDPHVERPDGAAEAPAWAEPGNVRPRRAQPGTGLMTLAEANEELARAERDYNMQNDQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHN4</accession>
    <name>A0A132PHN4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23795</name>
        <name evidence="3" type="ORF">AWC31_29850</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000018">
        <property type="protein sequence ID" value="ORX13647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853380.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29850"/>
    <dbReference type="EnsemblBacteria" id="KWX21869">
        <property type="protein sequence ID" value="KWX21869"/>
        <property type="gene ID" value="AFM11_23795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13647">
        <property type="protein sequence ID" value="ORX13647"/>
        <property type="gene ID" value="AWC31_29850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2117"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="134" mass="15198" checksum="C017EE5B4E95F1E9" modified="2016-06-08" version="1">MSKQSAAKKARRKKRQASRDARWVPDEVVQQLSAIQDAVVADLAEFDERITERGWTFDEEESDDNFAIWFYEPSGSEVEDGVPVTSLWLDAAEDGELVHVTFVGTVDKITFTHEDLFENLDAIEAYRVGDPTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHT9</accession>
    <name>A0A132PHT9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_23470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28195"/>
    <dbReference type="EnsemblBacteria" id="KWX21881">
        <property type="protein sequence ID" value="KWX21881"/>
        <property type="gene ID" value="AFM11_23470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2049"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="2"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="498" mass="50113" checksum="D22756C030389889" modified="2016-06-08" version="1">MTILATGLASSITAADPVILSANISSVRAGLDMTAGTASFVASIATLTLAAAVLGAGALGDKFGMKRMYTLGLLGTVMFGVLAAAAPNAPVLILCRAAEGVAFALLLGLSLAIVNVVFPPERRAGAISLHLGAGFVAAVPMPAVGSLLAQHVGWRTCFLVAPALALIALAMVLRYVPETPRNARRLDVPGLLLIAIALLAVVYGLSRLQTGLHAAAVVPIVVGLMAAAAFVVFELRTPDPALDLRIFRSGPFNAAVFAGVAFNFLSGGSTILCAFYLVTIRGESPTLLGLLMAPAALLSAIAAAAAGRAAARLGERAALVGGLLLLLGALLVLTVLGEDSPMWILFAVVGLNAVGAAVTETIEATVMLRTAPVELSGAVTAVKSAVGQAAYSLGPAVFALLGTTLFVHTSRDRLAGAGVTGEEAREALRVAHGGAGSSAGTNVLDPERAREVVEGATAGMLGAIHTMGWILTAVPVAAIVAVLILMRGTTRAPEGAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHU2</accession>
    <name>A0A132PHU2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_22295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852677.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08915"/>
    <dbReference type="EnsemblBacteria" id="KWX21906">
        <property type="protein sequence ID" value="KWX21906"/>
        <property type="gene ID" value="AFM11_22295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1809"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="287"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="522"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="592" mass="65004" checksum="C2CFC3C426C1F50E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHV0</accession>
    <name>A0A132PHV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_23500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28225"/>
    <dbReference type="EnsemblBacteria" id="KWX21883">
        <property type="protein sequence ID" value="KWX21883"/>
        <property type="gene ID" value="AFM11_23500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2055"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="337" mass="36052" checksum="263D59EF3BE00AC2" modified="2016-06-08" version="1">MSPRVSGKRPTLADVANRAGTSTAVVSYVLNNGPRPVSEALRAKVISAIDELNYRPDLRARALRRPRRWRQIGLLVPDLTLPLFGEFVGRLEVEARARDHLTLIGNTGYDAERELEFATAFAEVGIDGLVVIGAANAPHTAKLCRQERIPVVWMHNVRGDVAAEIVGVNHSRAGELVARHLADEHDCTDIAFVGGFTEADVHHGDRETVEQRFAGVSSVAGSRIPLVRTDLTPGGAYAAVSTFLREGDQVPRGFVVGTYGQTSAVVRAIVDAGLDVPGDVRVVGFDGPANDYAQLRLTAAQQPVDAIVRRALGLLLDDGASGDDLEPSLRVGDTCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI51</accession>
    <name>A0A132PI51_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyglutarate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852947.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08820"/>
    <dbReference type="EnsemblBacteria" id="KWX22038">
        <property type="protein sequence ID" value="KWX22038"/>
        <property type="gene ID" value="AFM11_22390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1828"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="402" mass="42863" checksum="CA20D2DBCCD8600C" modified="2016-06-08" version="1">MPKRVAVVGGGIVGVAVARELLQRQPDAEVTVFEKEDRLASHQTGRNSGVVHAGLYYQPGSAKALLCRRGVGLLEEYCAQRGIRRIACGKVLVALDDVERARLADIEDRARANGVPGIRVIGPAELRELEPHVRGVAALHSPSTSIVDFAEVTQALAADAAGAGAKILLGHEVIGMRATGTEVVITVRTGGGTDHAAFDQVIACGGLQSDRLAEMAGDGPDPVIMPFRGEYYALKPERRGLVNGLVYPVPDPRYPFLGVHVTPRVDGEVLIGPNAVLALAREGYTWKNVSVSDLAGVARTPAFWRFARRHWRTGIREMYGSLSKRRFVAAARAYVPELADDDVVAGTAGIRAQALDADGGLVDDFRISIRDRIVVLRNAPSPAATSALAIAEHVVGTLESET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIT9</accession>
    <name>A0A132PIT9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyQS</name>
        <name evidence="9" type="ORF">AFM11_20765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852070.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06180"/>
    <dbReference type="EnsemblBacteria" id="KWX22270">
        <property type="protein sequence ID" value="KWX22270"/>
        <property type="gene ID" value="AFM11_20765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1492"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="6"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="322"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="205"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="282"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="461" mass="52387" checksum="27C47E46C8E824BE" modified="2016-06-08" version="1">MASIIDTVANLAKRRGLVYQSGEIYGGTKSAWDYGPLGVELKENIKRQWWRSVVTGRDDVVGLDSAIILPRQVWVASGHVEVFNDPLVECLNCHKRHRQDHMQEAYAAKKGLDDPDAVPMDEIVCPDCGTKGQWTEPRDFNMMLKTYLGPIETEEGLHYLRPETAQGIFVNFANVVTTARKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPSTAGEWHQYWIDTRLEWYVDLGINRDNLRLYEHPKEKLSHYSDRTVDIEYKFGFAGNPWGELEGVANRTNFDLSTHSQHSGVDLSFYDQATETRYVPYVIEPAAGLTRSLMAFLVDSYTEDEAPNAKGGVDKRTVLKLDPRLAPVKAAVLPLSRNADLSPKARDLAAELRKSWNVEFDDAGAIGRRYRRQDEIGTPYCVTVDFDTLEDNAVTIRERDAMTQERVALDKVSDYLAVRLKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ23</accession>
    <name>A0A132PJ23_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetolactate synthase</fullName>
            <ecNumber evidence="5">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_20935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852130.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06355"/>
    <dbReference type="EnsemblBacteria" id="KWX22301">
        <property type="protein sequence ID" value="KWX22301"/>
        <property type="gene ID" value="AFM11_20935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1528"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="192"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="386"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX22301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="546" mass="56832" checksum="3FA9DB5D9324316A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ71</accession>
    <name>A0A132PJ71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_20575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851999.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05990"/>
    <dbReference type="EnsemblBacteria" id="KWX22237">
        <property type="protein sequence ID" value="KWX22237"/>
        <property type="gene ID" value="AFM11_20575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1452"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="89" mass="9567" checksum="4A23B92E8C2957F6" modified="2016-06-08" version="1">MVGDQEAIAAVLNRLRRAQGQLAGVISMIEQGRDCKDVVTQLAAVSRALDRAGFKIIATGLRECITDERAEGAEPIDVSELEKLFLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJB1</accession>
    <name>A0A132PJB1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19930</name>
        <name evidence="3" type="ORF">AWC31_28585</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000016">
        <property type="protein sequence ID" value="ORX14056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851868.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28585"/>
    <dbReference type="EnsemblBacteria" id="KWX22426">
        <property type="protein sequence ID" value="KWX22426"/>
        <property type="gene ID" value="AFM11_19930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14056">
        <property type="protein sequence ID" value="ORX14056"/>
        <property type="gene ID" value="AWC31_28585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1320"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX14056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="138" mass="15289" checksum="26C6B081A5B0072A" modified="2016-06-08" version="1">MAKLTRLGELEREVMDHLWSAPEPQTVRQVHEALAARRDLAYTTIMTVLQRLAKKNLVVQHRDDRAHRYAPTHGRDELVAGLMVDALDQAADSGSRQAALVHFVERVGADEAAALRRALAELESKHRIPPPTGNSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJQ6</accession>
    <name>A0A132PJQ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Catalase-related peroxidase</fullName>
            <ecNumber evidence="1">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_20305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has an organic peroxide-dependent peroxidase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11410"/>
    <dbReference type="EnsemblBacteria" id="KWX22494">
        <property type="protein sequence ID" value="KWX22494"/>
        <property type="gene ID" value="AFM11_20305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1395"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08153">
        <property type="entry name" value="srpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024168">
        <property type="entry name" value="Catalase_SrpA-type_pred"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000296">
        <property type="entry name" value="SrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0349">Heme</keyword>
    <keyword evidence="1 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000296-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000296-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="359" mass="38906" checksum="ED052ACBAB80BD5B" modified="2016-06-08" version="1">MTSMPKQQWPMLDRRKVLLGAAAVGGFLALDVGALLFATNTVGPRRLTPQTFVDGFRTVFGQHAGYRVNHAKGVAVSGYFDSNGDGQQLSSAAVFARGITPVLGRFSFGNGNPRVPDDPSLARGLGLVFGFPSDEQWRMALLNLPVFPDNSPQGFYDRLLAGKPVPATGKPDPAAMARFLADHPETARAMEIIKANPPTPGFADSTYRSLITFYFVNADGVRTPVRWSLVPMQPARPAFRGDNGMFDALIASMRTGPLRWRLLLTVGAPDDPVADATLPWPPDRRTVDAGVLTLDTVETERPGNSRDVNFDPMVLPDGIEPSDDPLLSARSAVYGASYRIRSREAQTSPPEVQVDEVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJR3</accession>
    <name>A0A132PJR3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851545.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_14960"/>
    <dbReference type="EnsemblBacteria" id="KWX22576">
        <property type="protein sequence ID" value="KWX22576"/>
        <property type="gene ID" value="AFM11_18870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1109"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="339" mass="36811" checksum="9DAAC205F23D8DFF" modified="2016-06-08" version="1">MTVTSLEGLDLAALDRHLRAEGISRTGELRAELIAGGRSNLTFLVFDDASKWVLRRPPLHGLTPSAHDMAREYRVVAALADTPVPVARAVTMRNDDSVLGAPFQMVEHVGGRVVRTQDELAALGDQAVIDGCVDALIKVLADLHAVDPAAVGLADFGKPDGYLERQVRRWGSQWEHVRLPDDARDDDVHRLHAALGQAVPPQSRSSIVHGDYRIDNTVLDAEDATKVRAVLDWEMSTLGDPLSDAALMCVYRSPMFEFVHSDAAWTSSKLPSAEDMAQLYSVQSGQELAHWDFYMALAYFKLAIIAAGIDFRRREGADGPEQVGEAVAPLIAAGLSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK91</accession>
    <name>A0A132PK91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851080.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05075"/>
    <dbReference type="EnsemblBacteria" id="KWX22760">
        <property type="protein sequence ID" value="KWX22760"/>
        <property type="gene ID" value="AFM11_17555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.866"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="104" mass="10840" checksum="F2992BEC66168074" modified="2016-06-08" version="1">MPVVVVATMKAKPESVDAVRAACTKAIEAVHDEPGCDLYSLHEADGTFVFVEQWADADALKTHSSAPAVGTLFGTVGELLDGTPDIKVLQPVVAGDPAKGQLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKV1</accession>
    <name>A0A132PKV1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxy-2-methylbutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850625.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19880"/>
    <dbReference type="EnsemblBacteria" id="KWX22968">
        <property type="protein sequence ID" value="KWX22968"/>
        <property type="gene ID" value="AFM11_16440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.636"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="26010" checksum="03605938F600FD3A" modified="2016-06-08" version="1">MEIKDAVAVVTGGASGLGLATTKRLLDAGAQVVVIDLKGEEVVAELGDRARFVGTDVTDEAGVSEALDVAESLGPVRINVNCAGIGNAIKTLSKNGAFPLDGFRKVVEVNLIGTFNVLRLAAERIAKTEPLGEERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIARDLSRELIRVCTIAPGLFKTPLLGSLPEEAQKSLGQQVPHPARLGDPDEYGALAVHIVENPMLNGEVIRLDGAIRMAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLN0</accession>
    <name>A0A132PLN0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01535"/>
    <dbReference type="EnsemblBacteria" id="KWX23154">
        <property type="protein sequence ID" value="KWX23154"/>
        <property type="gene ID" value="AFM11_16965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.746"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011875">
        <property type="entry name" value="M1P_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02149">
        <property type="entry name" value="glgA_Coryne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="188"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="382" mass="41197" checksum="5B8191693B61694C" modified="2016-06-08" version="1">MTREYPPEVYGGAGVHVTELVAQLRHLCEVDVHCMGAQRDGAFVAQPDPALRGANAALSTLSADLNMVNNAAQATVVHSHTWYSGMAGHLTALLYGIPHVLTAHSLEPLRPWKAEQLGGGYRVSSWVERTAIEAADAVIAVSAGMRDDVLHTYPALDPNRVHVVRNGIDTDVWYPTPPVPGESLLAELGVDLNRPIVAFVGRITRQKGVAHLVAAAHKFSNDVQLVLCAGAPDTPEIAAEVSSAVQELARARIGVFWVREMLPINKIREILSAATVFVCPSVYEPLGIVNLEAMACSTPVVASDVGGIPEVVADHQTGLLVHYDASDPEFFETRLADAVNSLVAEPDTARKYGEAGRQRCIEEFSWAHIAEQTLEIYRKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLN4</accession>
    <name>A0A132PLN4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxy-6-phosphogalactonate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.21" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850323.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16065"/>
    <dbReference type="EnsemblBacteria" id="KWX23260">
        <property type="protein sequence ID" value="KWX23260"/>
        <property type="gene ID" value="AFM11_15700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7263"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008674">
        <property type="term" value="F:2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="207" mass="21156" checksum="FC1E3FA3D4E1C725" modified="2016-06-08" version="1">MNDKPTGLVAILRGITPDEVLAVGSALVEAGFTAIEVPLNSPQPFDSIERLAAVTPAACAVGAGTVLTVDDVARAQDAGARIIVAPNADPDVISAAATRDLRPYPGVATPTEAFRAVAAGARSLKLFPSGAVGIAGMKAWRAVLPADVEMLPVGGVDEHNLADWATAGAGGAGLGSNLYRPGDDAAEVGRRARTLQNIWSKAERTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLP4</accession>
    <name>A0A132PLP4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_18205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851449.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12275"/>
    <dbReference type="EnsemblBacteria" id="KWX22932">
        <property type="protein sequence ID" value="KWX22932"/>
        <property type="gene ID" value="AFM11_18205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.998"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="229"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="446" mass="47534" checksum="D6BD09CD94DEEC87" modified="2016-06-08" version="1">MRVLSLRTIVIVAALSVVVTVLTLGTWVWIGVTNDQYSQLDRRLDSLSSLGDVSTLLNTARVDTDESTPDDGGLVRTAHIGGITVSVPSDIVLPQLENGYANTTIDGVEYRVRTFNAGPASIALGAPLAETQRRIDELHLRVVLICAGVIGSTVVVGWVISLVMINPFRLLAQQARAINAQSNPDEVQVRGVREAVEIAEAVEGMLARIGNEQERTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLDMTAEQRQEVIGDVMRTQSRIEATLTALERLAQGELTTVEDFVPMDVTELLDRAAHDALHTYPGLRATLMPSPTVLMLGMPAGLRLVIDNAIANAVKHGGATEIRLSAVSSADDVQIVVDDNGSGVPEAERAGVFERFARGSTASRSGSGLGLALVAQQAELHGGTASLEASPLGGARLLLRLPIIRSRVEDAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLS0</accession>
    <name>A0A132PLS0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="8">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lysS</name>
        <name evidence="11" type="ORF">AFM11_15930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8 9">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850402.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16505"/>
    <dbReference type="EnsemblBacteria" id="KWX23298">
        <property type="protein sequence ID" value="KWX23298"/>
        <property type="gene ID" value="AFM11_15930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7311"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="190"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX23298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="507" mass="56602" checksum="FC332DD2974181BD" modified="2016-06-08" version="1">MTPADSDATSESQADLPEQFRIRQAKRERLLAEGRDPYPVKVDRTHTLAELRSAHPELPADTQTGQIVGVSGRVVFARNSGKLCFATLQEGDGTQLQAMISLAQVGQESLDAWKSDVDLGDIVFVHGEVISSKRGELSVLADSWQMAAKALRPLPVAHKEMSEEARVRQRYVDLIVRPEARTIARQRVAVVRAVRSALERRGFLEVETPMLQTLAGGAAARPFVTHSNALDVDLYLRIAPELFLKRCLVGGFEKVFELNRNFRNEGVDSTHSPEFAMLETYQAYGDYNDSAIVTRELIQEVADDAIGTRQVPLPDGTIYDLDGEWATLEMYPSLSEALGDEITPDTPAEDLWRIADRLELEIPRDRGFGHGKLVEELWEHTVGEKLWAPTFVRDFPVETTPLTRAHRSIDGVTEKWDLYIRRFELATGYSELIDPVIQRERFEAQARAAAAGDDEAMVLDDDFLAALEYAMPPTTGTGMGIDRLLMALTGLSIRETVLFPIVRRQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLT7</accession>
    <name>A0A132PLT7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pilus assembly protein TadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_15665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850310.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16100"/>
    <dbReference type="EnsemblBacteria" id="KWX23253">
        <property type="protein sequence ID" value="KWX23253"/>
        <property type="gene ID" value="AFM11_15665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7256"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453406" evidence="6">
        <location>
            <begin position="27"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="49"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="189" mass="18704" checksum="2E70A29B06179B28" modified="2016-06-08" version="1">MSWAALFLAAALMIGVSPTRNRLAPATVHARAPRRSGNDDPLAAASTFDLFAACLSAGMAVSNAAAAAAPSAPPSLAPLLTRAADLLALGADPATAWSNDALPHDKNVDALLRLARRSASSGTALAHGVAELAGQSRHDAAAAADATAERASVLVAGPLGLCYLPAFLCLGVVPVVVGLAGDVLGSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMD8</accession>
    <name>A0A132PMD8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849872.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23499">
        <property type="protein sequence ID" value="KWX23499"/>
        <property type="gene ID" value="AFM11_14580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7027"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="365" mass="40477" checksum="954FA1CDCAB750CC" modified="2016-06-08" version="1">MTAPGPYAEANNVMVQLTRLACGWSRKRLADQAGVSGSHVSKVESGVLPLAGKALLDYARVMQCPPEALCVPFTRSPAEGTHFRANTSIAEWKRDRVWARANLIAMRLGRIQARADIEPVLALPELDPADYAAEHGEITAAQVLRRLWRVAGPIRSMVELLEAAGVFVVVEDFCDREIDAVTLRTSQHHPHLVYVNAALPPDRMRMTLAHELGHLVMDAMTLVSPVETERRATAFAAEFLAPIDDIAFDLDRVSIRTVHELDELRLTWGVSVASLVMRARERGILSDYQCRSMFRLLNETGRMYGPRPGVAEEEPKLVTSVLEQLMTAGYTTSEVDEITLLTSAQRADLFKTASDQPVTRHLTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PML1</accession>
    <name>A0A132PML1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17740"/>
    <dbReference type="EnsemblBacteria" id="KWX23580">
        <property type="protein sequence ID" value="KWX23580"/>
        <property type="gene ID" value="AFM11_15100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7132"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="248" mass="25600" checksum="BF070DAF764EA464" modified="2016-06-08" version="1">MQAGQQTVLFDAMGFTDMAVDAKNTLYLGGSLGIATLAPRADKPVPLEHGNLPVSTLAAAPDGTLYFVTLDNVVESLAPGSSAPDRLPFGELRQRSQIAVGKDGTAYLGDNQQGKLLTLAPGANSPSALPVEGVNGMGHMVVDANDNVFVSVMGKVVKIAKNATTVETVEGAPDNVGGLAVDAGGNLYATDIEANTVSRMPAGGGDWVQLPFSGIQSPTRIAVDDDGNVYVIAAIRDRGRQIIRLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMW0</accession>
    <name>A0A132PMW0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrB</name>
        <name evidence="12" type="ORF">AFM11_14740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849930.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18160"/>
    <dbReference type="EnsemblBacteria" id="KWX23604">
        <property type="protein sequence ID" value="KWX23604"/>
        <property type="gene ID" value="AFM11_14740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7057"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="453"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX23604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="675" mass="74300" checksum="A418AC8635449261" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNS3</accession>
    <name>A0A132PNS3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxyvinyl-carboxyphosphonate phosphorylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848270.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23988">
        <property type="protein sequence ID" value="KWX23988"/>
        <property type="gene ID" value="AFM11_11500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6376"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="292" mass="31204" checksum="09C616DD23F6ACA1" modified="2016-06-08" version="1">MTTTARARLRDLLDRRQLIVAPGVYDGISAHLVKRTGHVAAYLTGAGVAASGFGLPDIGLVTQTEMVERARMIVRALGDVPVLADADTGYGAPINVIRTVREYEDAGVAAIQLEDQAFPKRCGHLPDKELVSADDFVRTLTAALDARTDNGMLVIARTDARGPLGLDEAIRRANRYAAEGADLLFVEAPQSDHEIERIAAEVEAPLLLNLVLGGLTPEQSAQRLQQLGFAVAIHPSAVLAPSTLGALSALCQMRGIDAADLMPTTPEDFFNLVGMAEWATLGESYQPARQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNV4</accession>
    <name>A0A132PNV4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848344.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30385"/>
    <dbReference type="EnsemblBacteria" id="KWX24010">
        <property type="protein sequence ID" value="KWX24010"/>
        <property type="gene ID" value="AFM11_11640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6405"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025449">
        <property type="entry name" value="DUF4194"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13835">
        <property type="entry name" value="DUF4194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="239" mass="27370" checksum="82747D9C6E01518B" modified="2016-06-08" version="1">MSDTSIDFDALPSIDAVERSTPERRAPRFDGDASELPDRACWALQHLLSRRYIRKDNHAELWSWVTRYRTELTVRLSELDLRLCIADDHDIAYVEQAEYESQWRRKLLRRETLNTYDSILALHLAKLMRAAARDEDVLISREEIHELFAGVNNDTDRDAASFDKRIDNAIERLTDIEILVRNREDEGSFTVSPVINAIMTASVITELAQQFDQLKRAAGRGADDADADAVEDEVDAHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNZ1</accession>
    <name>A0A132PNZ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_11900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848487.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10070"/>
    <dbReference type="EnsemblBacteria" id="KWX24059">
        <property type="protein sequence ID" value="KWX24059"/>
        <property type="gene ID" value="AFM11_11900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6459"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="47"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="418" mass="48157" checksum="956E386530C0DFC2" modified="2016-06-08" version="1">MKRWPKPAEGSWTEHYPELGTGPVSFRDSTSPEFYEVEREAVFKRAWLNVARVEEVPAAGHYATKEIEAARASVILVRGADDELRAFHNTCRHRGNKLLWNDFPERETAGSAEFFECRQCGWRYGLDGTLTYVPEPFAVDTADYGLVPVHCDVWNGFVFINFDATPRQSLRDFLGPMITGLDDYPFHKLTERYDWVAHHNNSNWKIFADAFQEYYHVPSLHTQQVPPEVRDPNAGFTCGHFQLDGPHRLVSTAGTRRWLLAPEYMYPIERATRSGLVGPWRTPDIGELPPGLNPGGIEPWGISNFQIFPNTEILIYGGWYLLYRYWPTSHNTHRFEAYTYFHPARNVRERIEHEVAAVVLKEFALQDAGMLGGTQAALEYGIVDDYPLNDQEILVRHLHKVVVDWVDEYQRERTPAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNZ4</accession>
    <name>A0A132PNZ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11885</name>
        <name evidence="3" type="ORF">AWC31_30165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848479.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30165"/>
    <dbReference type="EnsemblBacteria" id="KWX24056">
        <property type="protein sequence ID" value="KWX24056"/>
        <property type="gene ID" value="AFM11_11885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12274">
        <property type="protein sequence ID" value="ORX12274"/>
        <property type="gene ID" value="AWC31_30165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6456"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX12274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="150" mass="16416" checksum="D0C3CD4DE285D557" modified="2016-06-08" version="1">MELTDNILWLLKQAFYFSLTTVNDAVSDHGVSTAQIGVLRQLANEPGLSGAELARRLLISPQGVQLALTALEKRGLVERKQNPQHGRILQAFLTDEGRSVAAAVVADAIAAHEKVFGVLTAEEQKTLRELLSRVVEKGTGHELFDDHVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP89</accession>
    <name>A0A132PP89_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding molybdopterin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848010.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31235"/>
    <dbReference type="EnsemblBacteria" id="KWX24159">
        <property type="protein sequence ID" value="KWX24159"/>
        <property type="gene ID" value="AFM11_11020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6280"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="277" mass="29747" checksum="176BF1EF00A17B48" modified="2016-06-08" version="1">MDLNTVEVVDRPTRRDELWPLATGDAILAGGTWLFSEPQPHLRRLIDITGLGWAPITLHDTGIELSATCTVAEVSRLSDSLSAHRPNWAAAPLLRQCCTALLASFKIWHHATFGGNICLSLPAGAMISLAVALDGEATVWRADGSDYRLPVADLVTGVGTNVLATADVLRCVHLPASALRGRTAYRKLAPSPLGRSGVVVIGRRDTAPDGGRFVLSVTGATVRPYVFTFSEVPDLRSVHDAHASIPVDAWTEDAHGDPDWRRAVTLVLAEQVRSELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQK2</accession>
    <name>A0A132PQK2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_07965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846210.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24565"/>
    <dbReference type="EnsemblBacteria" id="KWX24608">
        <property type="protein sequence ID" value="KWX24608"/>
        <property type="gene ID" value="AFM11_07965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5443"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="59" mass="6220" checksum="BA009CB887AFDF74" modified="2016-06-08" version="1">MPNPIDVQKALSGAKYPSSKQDLIEHAKTNGADSEIVDALGKLPDGEISGPDQVQKAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQM3</accession>
    <name>A0A132PQM3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08050</name>
        <name evidence="4" type="ORF">AWC31_24650</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000014">
        <property type="protein sequence ID" value="ORX15217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846256.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24650"/>
    <dbReference type="EnsemblBacteria" id="KWX24623">
        <property type="protein sequence ID" value="KWX24623"/>
        <property type="gene ID" value="AFM11_08050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15217">
        <property type="protein sequence ID" value="ORX15217"/>
        <property type="gene ID" value="AWC31_24650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5460"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX15217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="136" mass="15144" checksum="75B2314E248480BE" modified="2016-06-08" version="1">MPTGRVKWYDAEKGFGFLSQEEGEDVYVRSSALPAGVEGLKAGQRVEFGVAAGRRGPQALSLKLIDPPPSVSRNRREAERPEHKHTPDELHGMVSDMITLLEDIVQPELRKGRYPDRKVARRVSEVVKAVARELDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQP2</accession>
    <name>A0A132PQP2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846344.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00150"/>
    <dbReference type="EnsemblBacteria" id="KWX24651">
        <property type="protein sequence ID" value="KWX24651"/>
        <property type="gene ID" value="AFM11_08220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5495"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="390" mass="42015" checksum="FA3A9D2D1858B591" modified="2016-06-08" version="1">MTVTRLQPYAVTVFAEMSALATRLGAVNLGQGFPDEDGPAAMLKVAQNAIAEGANQYPPGLGIAELRQAIAAQRKRHYGIDYDPETEVLVTVGATEAIAASLIGLVEPGSEVVVIEPFYDSYSPVIAMAGCVRRAVPLVPEGRGFVIDLDGLRRAVTPKTRALILNTPHNPTGAVASDAELSAIAAVAVEHDLLVITDEVYEQLVFDGYRHMPLAGYPGMSARTVTISSAAKMFNVTGWKIGWACGAPELIAGVRAAKQYLTYVGGAPFQPAVAHALNNEDGWVADLRETFQTRRDRLGSALTDLGFEVHDSHGTYFLCADPRPLGYSDSAAFCAELPHKAGVAAIPMSAFCDPDAPHADVWNHLVRFTFCKRDETIDEAIRRLEVLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQT9</accession>
    <name>A0A132PQT9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846388.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00185"/>
    <dbReference type="EnsemblBacteria" id="KWX24665">
        <property type="protein sequence ID" value="KWX24665"/>
        <property type="gene ID" value="AFM11_08295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5510"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="160"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="31563" checksum="034B9B7D2DD66782" modified="2016-06-08" version="1">MKSPSERRGIVVGIDGSSSSDAAVRWAAQDAALRRVPLILVYAQGTAAAPVWLDVPLSEEYWQVQEQHGRDVLAAARRVAQEATATAEPLHIVEKLTPAHAVATLIDCSREADLVVVGSRGLGKWGRRILGSVSSTLVLHANGPVAVIHDGVSLSETAPVVVGLDGSPASELATEIAFDEASRRGVELVVVHTWNDLDYNFPDVRWTDLKPREERVLAEQLAGWAERYPDVAVRRIVMRDNPARQLLEQGESAQLIVVGSRGRGGFTGMLLGSVSSEVLHSARVPVIVARRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRH3</accession>
    <name>A0A132PRH3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="10" type="ORF">AFM11_05640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845052.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13015"/>
    <dbReference type="EnsemblBacteria" id="KWX24923">
        <property type="protein sequence ID" value="KWX24923"/>
        <property type="gene ID" value="AFM11_05640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4318"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="137"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="194"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="534"/>
            <end position="537"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="591" mass="64298" checksum="A45177BBCBA81359" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRQ8</accession>
    <name>A0A132PRQ8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein AFM11_05355</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_05355</name>
        <name evidence="6" type="ORF">AWC31_12725</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844965.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12725"/>
    <dbReference type="EnsemblBacteria" id="KWX24877">
        <property type="protein sequence ID" value="KWX24877"/>
        <property type="gene ID" value="AFM11_05355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18823">
        <property type="protein sequence ID" value="ORX18823"/>
        <property type="gene ID" value="AWC31_12725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4260"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX18823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="251" mass="26838" checksum="4181AF833F162D21" modified="2016-06-08" version="1">MSGHSKWATTKHKKAVIDAKRGKMFAKLIKNIEVAARVGGSDPAGNPTLYDAIQKAKKSSVPNDNIERARKRGGGEEAGGADWQNITYEGYGPNGVAVLIECLTDNRNRAAGEVRVAMTRNGGNMADPGSVAYLFSRKGVVTLEKNGLTEDDVLMAVLEAGAEEVNDLGDSFEIISEPTDLVAVRTALQDAGIDYESAEASFQPSVTVPVDLEGARKVLKLVDALEDSDDVQDVYTNIDIPDDVAAQLDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRT4</accession>
    <name>A0A132PRT4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 6">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_06365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 6"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845278.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29310"/>
    <dbReference type="EnsemblBacteria" id="KWX25049">
        <property type="protein sequence ID" value="KWX25049"/>
        <property type="gene ID" value="AFM11_06365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4467"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="32"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="415" mass="44620" checksum="0EC852FE970F5330" modified="2016-06-08" version="1">MTASAQTLDLTRIRADFPILNRVMRSGNQLAYLDSGATSQKPLQVLDAERDFLITSNGAVHRGAHQLMEESTDAYEQGRADIADFVGADSDELVFTKNATEAINLVAYVLGDKRFDRAVGPGDVIVTTELEHHANLIPWQELAERTGATLRWYGVTEEGRIDLDSLQLDERVKVVAFSHHSNVTGAIAPVAEFVARARAVGALTLLDACQSVPHQPVDLHALDVDFAAFSGHKMLGPTGIGVLYGRRELLNAMPPFITGGSMIETVTMEKTTYAPAPQRFEAGTPMTSQVVGLAAAARYLTDLGMASVEAHEAALVAAALEGLQGVPGVRIIGPQSLEHRGSPVSFVLDGVHAHDVGQVLDDEGVAVRVGHHCAWPLHRRFGIAATARASFAVYNTLDEVDRMVAGVKRAVEFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRY1</accession>
    <name>A0A132PRY1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_06405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845291.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25055">
        <property type="protein sequence ID" value="KWX25055"/>
        <property type="gene ID" value="AFM11_06405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4473"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="296" mass="32909" checksum="CA1B7BF06E0990CA" modified="2016-06-08" version="1">MSSDMIAQVRRFNRTVTQRAGVLYENYLASGRSLGQDRVLWEIGANGCDVRDLRSRLDLDSGYLSRLLRALQRDGLITVEPQADDRRVRTVWLTQAGRSELQTLNARSDDAAAAILTPLTATQQTRLVEAMAEVERLLTASTVRIAECDPRRPEARFCLDTYYAELAQRFPAGYDPAVSPVADEEMTPPAGLLLVASLHGQPVGCGALIWYPDAVALVKRMWVAPSARGIGLGRRMLSELESRARNHGDRLVRLDTNAALTEALNLYRTCGYREVAPFSDEPYANHWFEKSVAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRY4</accession>
    <name>A0A132PRY4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioA</name>
        <name evidence="6" type="ORF">AFM11_06770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845450.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28880"/>
    <dbReference type="EnsemblBacteria" id="KWX25118">
        <property type="protein sequence ID" value="KWX25118"/>
        <property type="gene ID" value="AFM11_06770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4553"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="315"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="432" mass="46029" checksum="606C9EA5A401158A" modified="2016-06-08" version="1">MADLTPAQISAIDSAHIWHPYSTIGAEALPPVVAVGAKGAWLTVIDPDDGRPIDVLDAMASWWTAVHGHGHPVLDGAINRQMATMNHVMFGGLTHEPAARLAQLLVELTPAGLETVFFSDSGSVSVEVAVKMALQYWRSLGRGGKHRLMTWRGGYHGDTFTPMSVCDPDGGMHSLWTDVLVAQEFAPPVPAEYDPAYIAAFERQLAEHADELAAVIVEPVVQGAGGMRFHDPRYLSDLRAICDRHDVLLIFDEIATGFGRTGELFAAEHAGVSPDIMCVGKALTGGYITLAATLCTGRIAQTISSGQPGALMHGPTFMANALACAVGVAAVELLIHSDWRTQVRAIEAGLRDGLEPARELAGVADVRVLGAIGVIEMAEPVDMRVATAAALRHGVWLRPFRNLVYAMPPYICTPAEVEQITAGMVGVARALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS05</accession>
    <name>A0A132PS05_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4333 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_06595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845350.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29080"/>
    <dbReference type="EnsemblBacteria" id="KWX25085">
        <property type="protein sequence ID" value="KWX25085"/>
        <property type="gene ID" value="AFM11_06595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4514"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025637">
        <property type="entry name" value="DUF4333"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14230">
        <property type="entry name" value="DUF4333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453283" description="DUF4333 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4333" evidence="2">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="115" mass="11525" checksum="89AE4F98F7B39872" modified="2016-06-08" version="1">MTKSRSRLLIVTAAIAAAALTGCGGAAQVDSPPTVAKTKLQSLAKAELEAAAGKKAKSVECEDGIAGVVGTTQRCVLTAKDGTKIGLTATVKGVEGEGKDANVNVDFKVDDKPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS18</accession>
    <name>A0A132PS18_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_06940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845508.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28710"/>
    <dbReference type="EnsemblBacteria" id="KWX25148">
        <property type="protein sequence ID" value="KWX25148"/>
        <property type="gene ID" value="AFM11_06940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4587"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019051">
        <property type="entry name" value="Trp_biosyn_TM_oprn/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011746">
        <property type="entry name" value="Trp_synth-assoc_CHP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09534">
        <property type="entry name" value="Trp_oprn_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02234">
        <property type="entry name" value="trp_oprn_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="21183" checksum="28206F3EE8CC4AAB" modified="2016-06-08" version="1">MMRIAQVLLVVAALGLWVASRMDWVQVSSFDGLGQPKSTDLNGATWSTALIPLALLVLAAAVAALAVRGWPLRLLAVLVAAASAGMGYLAISLWVIKDVAVRAADLAFVPVAQLTGTQRYYGGAVITLVAAVCALAGAVLLMRSAKGAQRRVSTRYAAPAARRAATRQDSDEPLSERMIWDALDEGHDPTGDQTDTDNKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS50</accession>
    <name>A0A132PS50_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06650</name>
        <name evidence="3" type="ORF">AWC31_29025</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845370.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29025"/>
    <dbReference type="EnsemblBacteria" id="KWX25094">
        <property type="protein sequence ID" value="KWX25094"/>
        <property type="gene ID" value="AFM11_06650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13831">
        <property type="protein sequence ID" value="ORX13831"/>
        <property type="gene ID" value="AWC31_29025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4528"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="244" mass="27570" checksum="657E89DF07BD04E5" modified="2016-06-08" version="1">MSVAILIAITLLCIMWSLWIRRVTWTCRWEVAATLNIALQGLAVLLMSPFASETVGQLLYHLTGKWNVEDYIGHDCYIVAASAVVYNALGRLQDDYGMQHSFKQYVERPATVCIPLLLAAFTFGNGAAVYRPDFFQVPTDFWLNVYWALLCGMLIYLLGYGVRAMLILRRDPRSRRIANIYLFASVSGILACVVRIVTAFVPQLQPIENGRMVWLFACTCGAVFALSAAHSWRLKTRVFTDARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS80</accession>
    <name>A0A132PS80_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_06805</name>
        <name evidence="2" type="ORF">AWC31_28845</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845884.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28845"/>
    <dbReference type="EnsemblBacteria" id="KWX25124">
        <property type="protein sequence ID" value="KWX25124"/>
        <property type="gene ID" value="AFM11_06805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13946">
        <property type="protein sequence ID" value="ORX13946"/>
        <property type="gene ID" value="AWC31_28845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4560"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX13946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="78" mass="8355" checksum="73373A8D79C02B96" modified="2016-06-08" version="1">MIDESPALPAPVGAGVYNVYTGGPAGSALPTTAQLGLEPPRFCAECGRRMIVQVRPDGWWAKCSRHGQVDSTELETQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS90</accession>
    <name>A0A132PS90_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845298.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29260"/>
    <dbReference type="EnsemblBacteria" id="KWX25057">
        <property type="protein sequence ID" value="KWX25057"/>
        <property type="gene ID" value="AFM11_06415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4475"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="74" mass="8800" checksum="3B75503998BB509A" modified="2016-06-08" version="1">MDCNELVELVTAYLDGALDPDTRVRFDMHLLECDGCERYLQQFRETVRTVGRITDDEIDPRFRNRLLNAFKDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSH8</accession>
    <name>A0A132PSH8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoadipate CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843858.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25299">
        <property type="protein sequence ID" value="KWX25299"/>
        <property type="gene ID" value="AFM11_03130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2497"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="212" mass="22120" checksum="4C16DDE912115B4E" modified="2016-06-08" version="1">MSNPLNRNEIAALVAADITPGSFVNLGIGLPTTVADHLPARAAIVLHTENGMLNMGPAATGDEIDPDLTNAGKAPVTELPGAAYFHHADSFAMMRGGHLDVCVLGAFQVSGAGDLANWHTGAPEAIPAVGGAMDLAIGAKQVFVMMTLFAKDGRPKFVPECTYPLTGLGCVSRVYTDMAILDITADGVCVRDTYGITFDELSTRLDVPLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSM5</accession>
    <name>A0A132PSM5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843850.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25295">
        <property type="protein sequence ID" value="KWX25295"/>
        <property type="gene ID" value="AFM11_03110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2493"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="282" mass="30627" checksum="298968F910141B9F" modified="2016-06-08" version="1">MSTVELLAGTWTTAGAANAGADDDRSPHTFQERVEVAAKAGFSGVGLGYLDLLDAEKKYGFATMRKILDDNGIRHFEIEMLLNWFVTDGRRADADIRRAEMLRAAEAIGARHIKVGGDFDGGDFDAEHMATEFTALAAQAADAGTRVVFEPMPFVNVRTPAQALEFIAKADHPSGLLLIDIWHVARAGVDFATLADIPARYIGDVEMDDAPLQFDGDIIADTFNGRRLPGEGELDVQGFVDAVRATGYDGIWGVEILSSDYRKLPITEAVPAAFDTTMKFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSN4</accession>
    <name>A0A132PSN4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFM11_03510</name>
        <name evidence="18" type="ORF">AWC31_21640</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844055.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21640"/>
    <dbReference type="EnsemblBacteria" id="KWX25356">
        <property type="protein sequence ID" value="KWX25356"/>
        <property type="gene ID" value="AFM11_03510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16622">
        <property type="protein sequence ID" value="ORX16622"/>
        <property type="gene ID" value="AWC31_21640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2576"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="16">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KWX25356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX16622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="284" mass="30203" checksum="82998AF1256BFDB1" modified="2016-06-08" version="1">MPELPEVEALADHLRRHAVGRVVTRVDVSALSVLKTFDPPITALHGETVTDAARWGKYLGLQAGSQWLITHLSRAGWLRWSDKLAPTPLKPGKGPIALRVHLGDGVGFDLTEAGTQKRLAVWVVSDPLDVPQIASLGPDALSLDSTGLAAVLAGQSGRLKTVITDQKVIAGIGNAYSDEILHVAKLSPFATAGKLTDAQLASLHDAMISVLTDAVSRSVGQQAATLKGEKRSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKVLADRRMSRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT29</accession>
    <name>A0A132PT29_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eno</name>
        <name evidence="13" type="ORF">AFM11_04205</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844424.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20950"/>
    <dbReference type="EnsemblBacteria" id="KWX25465">
        <property type="protein sequence ID" value="KWX25465"/>
        <property type="gene ID" value="AFM11_04205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2718"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="138"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX25465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="427" mass="44802" checksum="1B2D0D767D2F4DD1" modified="2016-06-08" version="1">MPIIEQVGAREILDSRGNPTVEVEVALIDGTFARAAVPSGASTGEHEAVELRDGGARYGGKGVEKAVEAVLDEIAPAVIGLGADDQRLVDQALLDLDGTPDKSRLGANAILGVSLAVSKAAAESAGLPLFRYIGGPNAHILPVPMMNILNGGAHADTGVDVQEFMVAPIGAPSFKEALRWGAEVYHSLKAVLKKQGLATGLGDEGGFAPDVAGTKAALDLISSAIEATGFKLGSDVALALDVAATEFYTEGSGYAFEKETRTADQMTEFYRGLIESYPLVSIEDPLSEDDWDGWVALTSAIGDRIQLVGDDLFVTNPERLEDGIERGAANALLVKVNQIGTLTETLDAVALAHNSGYRTMMSHRSGETEDTTIADLAVAVGSGQIKTGAPARSERVAKYNQLLRIEETLGDAARYAGDLAFPRLEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT54</accession>
    <name>A0A132PT54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04580</name>
        <name evidence="3" type="ORF">AWC31_20565</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844554.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25521">
        <property type="protein sequence ID" value="KWX25521"/>
        <property type="gene ID" value="AFM11_04580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16445">
        <property type="protein sequence ID" value="ORX16445"/>
        <property type="gene ID" value="AWC31_20565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2795"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453570" evidence="1">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="101" mass="10556" checksum="79BE1C53BB779E9A" modified="2016-06-08" version="1">MKNILVAAVGSSAAALGALLALAAPAQAESAALTIGQLEAQGFDVRLDRIGSAPLDQCIVTGVRNPQEQTRIVRFDGPGGRDRFVPVVVRRTITVSLDCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT96</accession>
    <name>A0A132PT96_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">potA</name>
        <name evidence="10" type="ORF">AFM11_07290</name>
        <name evidence="11" type="ORF">AWC31_17425</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845922.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17425"/>
    <dbReference type="EnsemblBacteria" id="KWX25272">
        <property type="protein sequence ID" value="KWX25272"/>
        <property type="gene ID" value="AFM11_07290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17536">
        <property type="protein sequence ID" value="ORX17536"/>
        <property type="gene ID" value="AWC31_17425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4658"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX17536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="372" mass="40739" checksum="2F400807736276C9" modified="2016-06-08" version="1">MEIDHVTKRFADYVAVADADFSIASGEFFSMLGPSGCGKTTTLRMIAGFESPTEGAIRLEGVDVSRVPPHKRNVNTVFQHYALFPHMTVWDNVAYGPRSMKKDKAEIKRSVDELLEIVRLTDFAKRKPGQLSGGQQQRVALARALVNYPSALLLDEPLGALDLKLRHAMQFELKRIQREVGITFIYVTHDQEEALTMSDRIAVMNAGNVEQIGSPTEIYDRPATVFVASFIGQANLWPGRQTGRINRDYVEVEVLGTTLKAKPGDTAIESGGHATLMIRPERVRVSMDAPTGDVATVPATVTDLTFQGPVVRLSLAAPDDSAIIAHVGAEQDLPLLRPGDRVHVSWAPDASRVLPAADIPTTEDLEEMLDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTB6</accession>
    <name>A0A132PTB6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844631.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20345"/>
    <dbReference type="EnsemblBacteria" id="KWX25560">
        <property type="protein sequence ID" value="KWX25560"/>
        <property type="gene ID" value="AFM11_04800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2841"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="222" mass="24055" checksum="D7CCA50D8B5590CE" modified="2016-06-08" version="1">MAQIAEDLFLLLLDNAAAQPGLDRRRRERVLSAAVLLDLAYSCRIRPAMAGEPVEPGLLIALAGNWPADPVADPAFQLLQRRPLSAQAALGKLSKHVQPSLETFLERAGQIRRVRIPGKGFPGRSVYCWPLTNRERVSQARAALLAALFDGHTPVPPIAAIICLLHAVDGLGAVLSLNERGWRWVHARATEISTGSWVDDNAAALPEMNLAVTTSTLRPALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTH5</accession>
    <name>A0A132PTH5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844042.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21670"/>
    <dbReference type="EnsemblBacteria" id="KWX25352">
        <property type="protein sequence ID" value="KWX25352"/>
        <property type="gene ID" value="AFM11_03480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2570"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="26104" checksum="3BF0F64BE146486F" modified="2016-06-08" version="1">MSAHTLGSSSVLAFDGVLDDTTYLPLRDSVIECALSGPDAVIVDVTDLQVPVYSAWSVFTSARWHVSVWPDVPVTLACQDDRGRERIARTGITRHVPVYPTVESACAAYEGRGQPSQRADASLPAVHSSLHRARELVIEWLLTWWHPDLIPVASIIVDVLVENVLEHTQSAPHLVAESRGDTVAIAVEDNSRAPAVRHEDPYHGAVAVSGLAVMAAVARAWGSTPTTTGKTVWALIGPENRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTI3</accession>
    <name>A0A132PTI3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WS_DGAT_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844816.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20015"/>
    <dbReference type="EnsemblBacteria" id="KWX25648">
        <property type="protein sequence ID" value="KWX25648"/>
        <property type="gene ID" value="AFM11_05325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2951"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045017">
        <property type="term" value="P:glycerolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WS_DGAT_C" evidence="2">
        <location>
            <begin position="275"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="417" mass="44239" checksum="146E3AA2FF6B916C" modified="2016-06-08" version="1">MRRLAAVDAQTWWMSAKLPSDQFLLYGFAGSPADLGRALTEVRNRAEACPELALRVRDEFRLTYPAWVPRRVGDDQFVVHNLDAPSWNDCLDAVAGLADHQLDATSATWRLHVFPSVRGIPDADTAGTAAVLQVAHALGDGIRSSALAAWLFGRPVPVPAVPAQPFVGATLPLRAVQAARTHRQLVADEKSGAVPLQAPSRPARRSNSRPAGARWVRTIVRPRARIPGPTVTVAVLAAVSVALGDHLRALGEDVVDLGAEVPMAKSGVRHAHNHFGNVGIGLYSELDHADRVARIAQDLAQRRTRARHPAMAAASRAFAATPAPLLRWGVAQFDPTLRSPVVTGNTVVSSVNRGAADLRFGAGPVVVTAGYPALSPMMGLTHGVHGIGDTLAISVHAAESAVGDIDSYVERLEQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTM0</accession>
    <name>A0A132PTM0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_03485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844857.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21665"/>
    <dbReference type="EnsemblBacteria" id="KWX25670">
        <property type="protein sequence ID" value="KWX25670"/>
        <property type="gene ID" value="AFM11_03485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2571"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="396" mass="41123" checksum="1C94FF95F7737D04" modified="2016-06-08" version="1">MGSSGSRTWLTRNVRVLSAVSFLQDTASELLYPLLPIYLTSVLGAPPAVVGAVEGAAEGAAAMTKLAAGPLGDRFAKRPLIATGYGMAALGKVMVAAAGAWQGVLAGRVVDRLGKGIRGAPRDALLVADVDAAARGRVFGFHRAMDTFGAVLGPLLGLVGYELLDHQIAPLLWVAIVPAVLSVALVFLVSEHRRETPRRDRQPVFARVRDLPGRYWRVTAVLVGFGLVNFPDALLLLRLNGIGFSVVEVILAYVTYNAVYAVASYPAGLLADRIGRVPVFGIGLVFFAVGYAGLGMTSDPVLAWLLIGAYGMFTACTDGVGKAWISSLVGPDLQGSAQGVFQGLSGFAVLAAGLWAGLLWGAVPGEPGQLPLLISGIAGGVFAVALLVAAVVSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTV3</accession>
    <name>A0A132PTV3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842067.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33230"/>
    <dbReference type="EnsemblBacteria" id="KWX25745">
        <property type="protein sequence ID" value="KWX25745"/>
        <property type="gene ID" value="AFM11_00120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.25"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="15"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="154"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="31125" checksum="2479DBB51C703FB4" modified="2016-06-08" version="1">MTVVVGYLVGKGGSSALHLAVGAARTLETSLAVATVVPRPWMTPSPARIDAEYAQYAAQLAASSAEQARERIAALDDELEVSFHKFAHRSVSDGLLEAVASLDAEALVLGSAADGKLGQVVVGSTADRLLHSCPVPLAISPRGYRRPKSGVLSRITCAYPGTRESVGVVRRIASITERLDTSMRVVTFAVRGRSMFPPLVGLQSEDAILQEWAAQARESLQQLKDDRIVDDDVELEVVTGDGWDEALDAVDWLDGEILAIGTTPAGVVARVFLGERGSKILRHSPVPVLVLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUB4</accession>
    <name>A0A132PUB4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_00795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842429.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33835"/>
    <dbReference type="EnsemblBacteria" id="KWX25864">
        <property type="protein sequence ID" value="KWX25864"/>
        <property type="gene ID" value="AFM11_00795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.163"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="563" mass="60685" checksum="680517883787D366" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUH7</accession>
    <name>A0A132PUH7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_01430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842769.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25965">
        <property type="protein sequence ID" value="KWX25965"/>
        <property type="gene ID" value="AFM11_01430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.293"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="105" mass="10997" checksum="69F589108403F55F" modified="2016-06-08" version="1">MAWALLIFAGLLEIVWALAIKQSDGFTRLWPSVVCVTAAAASFVILAIAVKQLPVGTAYAVWAGIGAVGVTVAGVALFSDALSPWRMTFIALIVVGLIGLRLVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUK0</accession>
    <name>A0A132PUK0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyroglutamyl-peptidase I</fullName>
            <ecNumber evidence="6">3.4.19.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_01650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842865.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25993">
        <property type="protein sequence ID" value="KWX25993"/>
        <property type="gene ID" value="AFM11_01650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.340"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033694">
        <property type="entry name" value="PGPEP1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01334">
        <property type="entry name" value="PYRASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="215" mass="22289" checksum="97A2C8C7F172B431" modified="2016-06-08" version="1">MTRALVTGFGAYADENDNPSGLIAQRLNGQQIDGVEIAGRVLPVDTELVHEMLTEAVDAVQPAVVVLTGVAPGRTAPALERVAINVRDFPIPDTAGRSPIDEPVVGGGPPAYLSTLPVKAIADGWRRAGLAGYVSNTAGTYLCNQVFYLARHLCRASDARVGMVHLPVTPARSVASTPPLPSVPIAALEHQVRLAVSIAARHDGADLPIGGGAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUL8</accession>
    <name>A0A132PUL8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843040.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34815"/>
    <dbReference type="EnsemblBacteria" id="KWX26048">
        <property type="protein sequence ID" value="KWX26048"/>
        <property type="gene ID" value="AFM11_02035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.417"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="57"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="559" mass="59586" checksum="42320AB7C8443542" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUP2</accession>
    <name>A0A132PUP2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_01980</name>
        <name evidence="9" type="ORF">AWC31_34760</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843019.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34760"/>
    <dbReference type="EnsemblBacteria" id="KWX26040">
        <property type="protein sequence ID" value="KWX26040"/>
        <property type="gene ID" value="AFM11_01980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11819">
        <property type="protein sequence ID" value="ORX11819"/>
        <property type="gene ID" value="AWC31_34760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.405"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX26040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX11819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="261" mass="29133" checksum="336B1027462149D7" modified="2016-06-08" version="1">MSAPVIDKPETGDPELPPVPEGAVMVTLKIARFNPDNPDAAGWQSFRVPCLPSDRLLNLLHYVKWYLDGTLTFRRSCAHGVCGSDAMRINGVNRLACKVLMRDMLPKKAGKQLTITIEPIRGLPVEKDLVVDMEPFFDAYRAVKPFLVTSGNAPTKERIQSPTDRARYDDTTKCILCACCTTSCPVYWSEGSYFGPAAIVNAHRFIFDSRDEAAAERLDILNEVDGVWRCRTTFNCTEACPRGIQVTQAIQEVKRALMFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUT8</accession>
    <name>A0A132PUT8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_00400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842226.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33515"/>
    <dbReference type="EnsemblBacteria" id="KWX25792">
        <property type="protein sequence ID" value="KWX25792"/>
        <property type="gene ID" value="AFM11_00400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.81"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="12"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="479" mass="49949" checksum="246C6A4EB631D1C5" modified="2016-06-08" version="1">MTQGANFVDGQWVPAVSGRTFQRRNPADPDELIGTFPASDAADVRAAVDALEKAAPEWAATPPERRAAILESAAAQLESRADTLIAELVSEEGKTKAEATMEVSRTPANLRFYAGEATRTTGSTYPSAGDNLVYTLREPVGIVAAITPWNFPFNIPSRKIGPALAAGNPVLYKPSEVTPLMGQRLVEALLDGGLPPAAIALVQGDGTAGAAVAADPRVAAVTFTGSTRVGRAIHREVGPERRVQLEMGGKNPVVVAADADLDGAAALIVKGAFGLSGQACTGTSRVVAVDAVHDALLERVIAKTEALQVGPGNQPGVNMGPLASADQLDKFLHYVQAGVAEGATLRCGGTTVGERGFFVRPTVFADALPTMRIVAEEVFGPLVAFQRAATLDEAVALANATEYGLSASIVTSDLATATHFARQSRTGLVKINQPTTGMAMNAPFGGYKSSSTQTYKEQAGATLMEFYTLEKTVYLNPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV20</accession>
    <name>A0A132PV20_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_02720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13502"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843409.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35495"/>
    <dbReference type="EnsemblBacteria" id="KWX26163">
        <property type="protein sequence ID" value="KWX26163"/>
        <property type="gene ID" value="AFM11_02720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.559"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="8"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="127"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="522"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="503"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX26163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="599" mass="63183" checksum="D53760FB1C74E04D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV61</accession>
    <name>A0A132PV61_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843632.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26248">
        <property type="protein sequence ID" value="KWX26248"/>
        <property type="gene ID" value="AFM11_01520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.311"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="473" mass="51324" checksum="C716476DB976203B" modified="2016-06-08" version="1">MRHYIDTLTDKLGADEVQTIKGANWDLEIGCITELSAEKEGPALLFDDIPEYPSGYRVFTNFMGTVSRCAVALGLPAETPAMDIIRAWKDLGKRIEPIPPVEVSEGAVLENVLEGDEVDLGMFPAPKWHDGDGGRYIGTACMVITRDPDTGWVNVGTYRGCVQGKDRLSLWMLGNRHALAIAKKYWDRGAACPIAVVVGCDPILTTAAAIAAPSGVSEYDVAGGLRGVGVEVIAAPGTGLPIPANAEIVFEGEMPPVEEESAHEGPFGEWTGYFTHAGDETVVRVQRILHRDSPIILGAPPMIPTVPAGDQAVPLYSASVTWDHLEASGVQNIRGVWAYARQLMMVISIEQTGAGDAMHALLAAAGRKRTGGVDRYFVVVDEDIDVTDINHVLWALFTRVDPAESIHVLRTPTTAIDPRLSPAKRDAGDMSMGIVLIDACKPFAWKDSYPRSNRFDEPYRAEVRDRWKATLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVA5</accession>
    <name>A0A132PVA5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Error-prone DNA polymerase</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dnaE2</name>
        <name evidence="14" type="ORF">AFM11_01490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-C family. DnaE2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842799.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34460"/>
    <dbReference type="EnsemblBacteria" id="KWX26245">
        <property type="protein sequence ID" value="KWX26245"/>
        <property type="gene ID" value="AFM11_01490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.305"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01902">
        <property type="entry name" value="DNApol_error_prone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023073">
        <property type="entry name" value="DNA_pol_error_prone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294:SF4">
        <property type="entry name" value="PTHR32294:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="13">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX26245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1096" mass="119162" checksum="06DB4B77D5995C41" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAY6</accession>
    <name>A0A132PAY6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000055">
        <property type="protein sequence ID" value="KWX19427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047041181.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000055.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19427">
        <property type="protein sequence ID" value="KWX19427"/>
        <property type="gene ID" value="AFM11_35945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6267"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="10"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="268" mass="28516" checksum="130AF46C6405080F" modified="2016-06-08" version="1">MNVSAAGQCEIVAVALQKGGVGKTTTTINLGASLAAMGFRVLLIDMDQQAHSTKGLGVDLGADDASMYEVLHPDRAMRVPLPTVIRPSEFGIDVAPGHLALKELERTGLGSGGQLRLARQLDDLEGYDFVLMDCPPALGELTTAALAAADYVLAVLKAGPDEIDGLVELGNAVLDVQETLNPDVEIRYVLLADFDGNPKASKDVRRQLRTDWGEWSAGGAYLGEIPHTVRVVEAKGKRIPVQVHAPTCTAAVAYREIAERIVARRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAZ8</accession>
    <name>A0A132PAZ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000052">
        <property type="protein sequence ID" value="KWX19437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067860010.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22505"/>
    <dbReference type="EnsemblBacteria" id="KWX19437">
        <property type="protein sequence ID" value="KWX19437"/>
        <property type="gene ID" value="AFM11_35885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6256"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="299" mass="32332" checksum="C90CF66DC100881F" modified="2016-06-08" version="1">MSDRHATPTIDVVVDLKTTLGEGPLWDCEQQLLYWIDSADGRIFRSTADGSQIRAWDVGQKIGSMALCRDGAHAIVALANGLHKLDLADGTLTELIDPEAGLPNNRLNDGKVDKRGRFVFGSMDTLEESASGKLYSYRPDGSLAVLDEGITVSNGPCWSPDGETLYFCDTWTGEIWAYDYDLDTGMVANRRTFARVDTSSGGAADGATVDADGYLWQALVYGGKIIRYAPDGSVDRVIDFPVRKPTSVMFGGADLDVLYVTSMARPPLPRFPGDGQLRGSLFAIRGLGVHGIPETRFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB49</accession>
    <name>A0A132PB49_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859748.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19553">
        <property type="protein sequence ID" value="KWX19553"/>
        <property type="gene ID" value="AFM11_35275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5785"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="831" mass="84229" checksum="50085437BC7ED0F8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBB2</accession>
    <name>A0A132PBB2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859616.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19608">
        <property type="protein sequence ID" value="KWX19608"/>
        <property type="gene ID" value="AFM11_35020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5733"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="168"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="399" mass="44511" checksum="46DFA56E50896640" modified="2016-06-08" version="1">MYFPYDEYESRWNTVLDAMRQRGFDWALIWGRSGGTFERCNDILYLSNYYSSQSGHEYDSSEWMGVSFSAMLLGGQDLPEMIVDEPDFPADLLPLPASNVTWEPQLIEGVAKLIRSKPISRIAMVGTDFLPVKYARLLEAELPGVEFVEADDLVREVRKHKSPRELDCYREIGVKVTAAMDVMVHAATKGGVTQAEVAALGAAELMRHGGVPHMVPVSSGPTMFQHCGDPILGFSPNVMLEKGDMVRMWIYGPAFQGYWSDPGRTVIVGGRGTARQRQLIENANHIITTLMNEIRPGRKFSEIAALGNELRASMDTEEDQPGKMWPIYGHGVGLFWEDPWLTAAAANPTGPDPVFHEGQTYSTETFLHWSDVGSAGVEQNFIVWENGNELLTTTDLVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBM2</accession>
    <name>A0A132PBM2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ORF">AFM11_34390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859231.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11280"/>
    <dbReference type="EnsemblBacteria" id="KWX19731">
        <property type="protein sequence ID" value="KWX19731"/>
        <property type="gene ID" value="AFM11_34390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5222"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="7"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX19731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="228" mass="23776" checksum="B88ACBA9CC6C5508" modified="2016-06-08" version="1">MSGSLVVAVDGPAGTGKSSVSRGLARALGARYLDTGAMYRIATLAVLRAGADLGDPEAIDRAAADVAVNVGSDPDEDRAYLAGEDVSAEIRGDAVTRAVSAVSAVPAVRARLVDLQRGLAAGGGRVVVEGRDIGTVVLPDADVKIFLTASAEERARRRNAQNIANGLSDDYETVLADVQRRDHLDSTRPVSPLRAADDALVVDTSDMDETQVIAHLLDLVTQHAGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBR1</accession>
    <name>A0A132PBR1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_35955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000057">
        <property type="protein sequence ID" value="KWX19422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_053855802.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19422">
        <property type="protein sequence ID" value="KWX19422"/>
        <property type="gene ID" value="AFM11_35955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6270"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX19422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="445" mass="48419" checksum="CD67F10E17F2D79A" modified="2016-06-08" version="1">MDGVLVEAVSTVEMAEALRASGAVDDLLAQIDTGEVALTGEGGLLPGLIKLALERGLAAELTDHLGYEKGDPAGRVLPNARNGSSPKTVLTEAGPVPLDVPRDRDGSFTPTLVPKGTRRIGGLDDMIVSLYAGGMTLRDIQFHLQSTIGTEVSHETISKIVDEISDEVLAWQRRPLEPLYPVIYLDAMIVKVKDGGHTRNKAAHIAVGVDMAGVKHVLGIWVQPNEGASFWASVCADLANRGVKDVLIVCCDGLTGFPEAIAATWSQAAVQTCVVHLIRNALRFVSYADRKAVAAALKPIYTAPDADAARVELDAFAASELGKKNPTVTMVFERAWEQFIPFLAFPPELRRVIYTTNSIESLNYQLRKIIKNRGQFPNDASAVKLLWLAICNIEDKRAAQRAKERGQKQGRTAPGRLVEGQVVTNWKKALEQLALVYPERIERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC18</accession>
    <name>A0A132PC18_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpF</name>
        <name evidence="16" type="ORF">AFM11_33335</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858644.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19866">
        <property type="protein sequence ID" value="KWX19866"/>
        <property type="gene ID" value="AFM11_33335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4999"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="91"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KWX19866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="165" mass="17146" checksum="3D9C7AAEAEDF2A3C" modified="2016-06-08" version="1">MSDLTILAAEEGGGGQSNFLVPNGTFFAVLIIFLIVLGVIAKWVVPPISKVLAEREAMLAKTAADNRKSAEQVAAAQADYDEAMAGARAQASSIRDEARASGRQVVDEKRAEASGEVAETVRQADEQLSAQSDQVRGGLESSVDGLSATLASRILGVDVKSGGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC26</accession>
    <name>A0A132PC26_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_33410</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858684.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02305"/>
    <dbReference type="EnsemblBacteria" id="KWX19880">
        <property type="protein sequence ID" value="KWX19880"/>
        <property type="gene ID" value="AFM11_33410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5014"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="14">
        <location>
            <begin position="36"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)" evidence="13">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX19880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="364" mass="38087" checksum="B31E297F65F1C949" modified="2016-06-08" version="1">MSSTKAGQVARVHQPWPGLIEAYRDRLPVGDDWTPITLLEGGTPLIHAKRLSEYTGCTVHLKVEGLNPTGSFKDRGMTVAVTESLARGQQAVLCASTGNTSASAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMTADFPTIALVNSVNPYRIEGQKTAAFEIVDALGTAPDVHALPVGNAGNITAYWKGYTEYHRDGLTDRLPRMLGTQAAGAAPLVLGEPVKEPETIATAIRIGSPASWSSAVEAQQQSEGRFLAATDEEILAAYHLVARTEGVFVEPASAASIAGLLKSVEDGWVKRGSTVVCTVTGNGLKDPDTALKGMPAVTPVPVDPVAVVAKLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCT6</accession>
    <name>A0A132PCT6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858352.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32350"/>
    <dbReference type="EnsemblBacteria" id="KWX20037">
        <property type="protein sequence ID" value="KWX20037"/>
        <property type="gene ID" value="AFM11_32905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4910"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="136"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="244" mass="25780" checksum="AEC8421DEE9B395D" modified="2016-06-08" version="1">MRIALFATCLADALFPPAAIATVQLLERLGHQVVFPSSQTCCGQMHINTGYLKEAVGVVRNHVESFESAGCDAVVAPSGSCVGSVRHQHAMVARRAGDEALATRAENIASRTYELSEFLIDVLGVDDVGAYYPHRVTYHPTCHSLRMLGVGDKPLRLLRNVRGLTLVELPAADSCCGFGGTFAIKNSDTSTAMLADKMGHILDTGAEVCSAGDSSCLMHIGGGLSRLRSGVRTVHLAEILAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDA3</accession>
    <name>A0A132PDA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857707.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26300"/>
    <dbReference type="EnsemblBacteria" id="KWX20315">
        <property type="protein sequence ID" value="KWX20315"/>
        <property type="gene ID" value="AFM11_31680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4240"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="259" mass="28242" checksum="90ACB627D30EB4B8" modified="2016-06-08" version="1">MTLETILLNLDHDSRVATVTLNRPEALNSFNRTMCEEMRDVWQTIKTDEGINAVVLRAAGDRAFSAGLDVKSSYGQPNIVWNHEDPGELLSPKWQKMWKPVVCAVQGMCTAGALYFVNEADVVICSQDATFFDSHVSAGLVSALEPVGLMRRVGLGDTLRIALMGNDERLCADTALRIGLVTEVVARDGLWARAHEIAATIAAKPPTATQGTVKAIWESLDKPYRAAMDQGLIYTRLGNPIAKAELAELKAAKPAPRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDG1</accession>
    <name>A0A132PDG1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30950</name>
        <name evidence="3" type="ORF">AWC31_26670</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857210.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26670"/>
    <dbReference type="EnsemblBacteria" id="KWX20370">
        <property type="protein sequence ID" value="KWX20370"/>
        <property type="gene ID" value="AFM11_30950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14749">
        <property type="protein sequence ID" value="ORX14749"/>
        <property type="gene ID" value="AWC31_26670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4092"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX14749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="180" mass="19015" checksum="C03AA89AD3B1C10F" modified="2016-06-08" version="1">MADIKVLVLVGSLRAASINRQLAELAVETAPDGVDLRIFDRLAELPFYNEDIDTQDVAEPVAALREAAAGADAALVVTPEYNGTIPAVLKNAIDWLSRPYGNGALKEKPVAVIGAALGQYGGVWAHDETRKSLGIAGPRVVEDLKLSIPAKVFDGKHPRENAEVAANLRDVVGKLAAEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDG7</accession>
    <name>A0A132PDG7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857273.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20391">
        <property type="protein sequence ID" value="KWX20391"/>
        <property type="gene ID" value="AFM11_31080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4119"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453215" evidence="1">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="98" mass="9497" checksum="0830C6D34481C3E8" modified="2016-06-08" version="1">MMTVKHAVLVGGFAVAAVLGQVAVAAPAEAKRCPSGTVQSKFEGVCVKGASGGGLVPVLPPSGGGPVIGGQPGGLATVNGIPCTKEHYGTCLAMTQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDH4</accession>
    <name>A0A132PDH4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_31580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857587.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26195"/>
    <dbReference type="EnsemblBacteria" id="KWX20277">
        <property type="protein sequence ID" value="KWX20277"/>
        <property type="gene ID" value="AFM11_31580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4221"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="236" mass="26027" checksum="7C6F21CEEEB57FF4" modified="2016-06-08" version="1">MTEQLDRRAHLTRLQILQAAAGQFARKPYSLVSLDDILADAAVTKGALYFHFRSKHALASSIVDHRAEQSRIAVDEVLARNLSGLETLIDITCLVAAEDIGDAMARAGLNLVESIGRTDGLGPRVLDAWIHGFTDIARRAVDEGDIVDDSDPRTVARLLVSMYLGTRQTSDLDDPQRFLTDLEQNWNLVLPGFANPDRLGYLSQFIRRRTALTIRKASPFGRDEPDLDTTARTGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDJ2</accession>
    <name>A0A132PDJ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe3+-citrate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_31065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857270.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26775"/>
    <dbReference type="EnsemblBacteria" id="KWX20390">
        <property type="protein sequence ID" value="KWX20390"/>
        <property type="gene ID" value="AFM11_31065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4116"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453021" evidence="2">
        <location>
            <begin position="31"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="93"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="355" mass="36788" checksum="FEFDEE4AA3FA517C" modified="2016-06-08" version="1">MLRNRALASALLTVAAVTLASGCGSEDATPASQPSMTTSVTKIADAGVLGNQRRPDESCAPDPPPADPAPREVRNARGADIPETTEMRGDPQRIVVLSGDQLDALCALGLQARIVAAALPDGSSTQPSYLGTVVHEVAPAGTRGAPDLAAIEAAKPDLILGSQALTPSSFGALAAIAPTVFTGTPGADWRDTLRAVGASTGRAGAADDLIEKFDDAARKTGADNDAAHFQASVVQLTENTVRVYGADNFPGSVLAAVGLDRPAAQRFTDKPYEELSTSDADYSIADADIVYVSFASAAARDNATAILDSDAWRALSAARDNRVFVVNNEVWQTGQNIVAARGILDDLRWVNAPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDR9</accession>
    <name>A0A132PDR9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856893.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20481">
        <property type="protein sequence ID" value="KWX20481"/>
        <property type="gene ID" value="AFM11_30380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3974"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="134" mass="15201" checksum="5FE2E6CD1DD79FB0" modified="2016-06-08" version="1">MSHRIVRNVKAERVRLALLEARPAGLTIEQLCTATGLTTSQVRGGLTEIREHAAMEHLTPLTWSHGQGYCFSREPADWIAYERAQVHTGLNRFVRLIKGTAYPHAQLEPDDDWIRLVFDQLIGVRAMLEGITRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDS9</accession>
    <name>A0A132PDS9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_30375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856890.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00920"/>
    <dbReference type="EnsemblBacteria" id="KWX20480">
        <property type="protein sequence ID" value="KWX20480"/>
        <property type="gene ID" value="AFM11_30375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3973"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="650" mass="66394" checksum="5562839D0DCB0CB3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDU3</accession>
    <name>A0A132PDU3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone biosynthesis methyltransferase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856955.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00510"/>
    <dbReference type="EnsemblBacteria" id="KWX20501">
        <property type="protein sequence ID" value="KWX20501"/>
        <property type="gene ID" value="AFM11_30505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4001"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="49"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="209" mass="23581" checksum="1A6A7A0874619925" modified="2016-06-08" version="1">MATDDRTARWNRYWDKKSRTYDREIGFFDRHLFGDSRQWVCSQATGTTLEVAVGTGLNLPFYPKDVILTGIDWSQQMLDLARRRAADLGHPASLQQADAHHLPFDDASFDTVVCTFGLCAIPDHSQALNEMTRVLRPGGKLILVDHIRSSAAPVRAVQRVLELVTVPLGGEHFLRRPLIHLRAATNVNIEHVERFTLGLVERLTARKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDX3</accession>
    <name>A0A132PDX3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_30470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856936.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00475"/>
    <dbReference type="EnsemblBacteria" id="KWX20494">
        <property type="protein sequence ID" value="KWX20494"/>
        <property type="gene ID" value="AFM11_30470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3993"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453202" evidence="2">
        <location>
            <begin position="29"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="90"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="152" mass="16024" checksum="42BE1BBC52A7287B" modified="2016-06-08" version="1">MRPLHLRNACGIAAGALLLVGLTGCASAGSPTATQSEVPPASTAPALHQAHSVDPQQFDALIADPKRLTINVHVPYEGDIAGTDLSIPFDQIPARADALPPERTTPLAVYCRSGRMSQIAATALSRMGYQDVVELNGGTLAWEKSGRSLVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE18</accession>
    <name>A0A132PE18_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29660</name>
        <name evidence="6" type="ORF">AWC31_25000</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856493.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25000"/>
    <dbReference type="EnsemblBacteria" id="KWX20571">
        <property type="protein sequence ID" value="KWX20571"/>
        <property type="gene ID" value="AFM11_29660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14462">
        <property type="protein sequence ID" value="ORX14462"/>
        <property type="gene ID" value="AWC31_25000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3824"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX14462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="62" mass="6762" checksum="76D2365294E0A6C5" modified="2016-06-08" version="1">MRVTVDLSLCQDHGQCAIAAPAVFTMNDDGKLEFNGNPDDSERDYVEEAADVCPAQAIFIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEX1</accession>
    <name>A0A132PEX1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpE</name>
        <name evidence="15" type="ORF">AFM11_27740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855685.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10275"/>
    <dbReference type="EnsemblBacteria" id="KWX20889">
        <property type="protein sequence ID" value="KWX20889"/>
        <property type="gene ID" value="AFM11_27740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3422"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX20889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="82" mass="8219" checksum="582AFDB411A589D0" modified="2016-06-08" version="1">MATEELMGNALLAGAITLAGGAIGAGIGDGIAGSQFIAGVARQPEAQSRLFTPFLITVGLVEATFFINVAFMALFVFATPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFG3</accession>
    <name>A0A132PFG3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855194.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06720"/>
    <dbReference type="EnsemblBacteria" id="KWX21014">
        <property type="protein sequence ID" value="KWX21014"/>
        <property type="gene ID" value="AFM11_26870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3247"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="PTHR31009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="360" mass="39350" checksum="59AD8B2F15DC8C31" modified="2016-06-08" version="1">MPESRVNARSDATAGGTRKKSPPRQHAAGLDSAIKLFEQAARTVPLPAAPYPIVIADYGAGSGHNSMRPIAAAVAALRGRTRPAQCVLVTHTDTAENDFTTMFRGLAEDPESYLRKDSATFTSAVGRSFYTQILPSNAVHLGWSAWALVRLGTVPMPIGDHIAVAYSGDDRTRAAYARQAAHDWHEFVAFRGRELSPGGRLVVMTMALGDDGDFGYRPLFDAVMDTLQELVAERVVSADEVKRMTLPIVGRRAADFAAPFAPSGRFEKLSISHLEVFDAEDVIFGQYRKDKNADAFGTRWADFCRFTALDDLADALGDDPERRLQFFERMHAGIAARLAAAPEQMRIPVAQLVLEKRQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFI6</accession>
    <name>A0A132PFI6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ORF">AFM11_27245</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855366.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07180"/>
    <dbReference type="EnsemblBacteria" id="KWX21073">
        <property type="protein sequence ID" value="KWX21073"/>
        <property type="gene ID" value="AFM11_27245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3324"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KWX21073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="241" mass="23521" checksum="DF9F7C2D10AB160F" modified="2016-06-08" version="1">MIRSLAGSFAFGTVLPVRSSAGLGRGAMTAFPIVGLALGALAAVVVWAGHWAFDPANPLPGVLAVAALLLATRGLHIDGFCDTVDGLGCYGPPERALAVMRDGSAGPFGVAAVVVTIAAQALAFTELSAVAIITAVAAGRVAAVAACRRSVPAAAGSSLGAAVAGSQPVVVVLGWAAALAALAVFAGPRPWQGPLVVVVAVLCSIGLVAHCVRRFGGITGDVLGAAVEVTTTVTALGLAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFN1</accession>
    <name>A0A132PFN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855564.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06990"/>
    <dbReference type="EnsemblBacteria" id="KWX21140">
        <property type="protein sequence ID" value="KWX21140"/>
        <property type="gene ID" value="AFM11_27140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3303"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453291" evidence="1">
        <location>
            <begin position="29"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="83"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="495" mass="52511" checksum="5F55182A0EDCB2C8" modified="2016-06-08" version="1">MAAVRWVGGILTAMLLALPAVVMPVASAAPPAWGTCANWIPDVSAIPTAQCGTVAVPVDYADPQGAQAQLAVIRVPATGDRLGVLMVNPGGPGASAVDTVAGMGAALADTEIGRRFDLVGFDPRGVGHSTPQLRCRTDAEFDAYRREPMADYSPAGVAHIEGLYRQFAQQCLDRMGAPFLANIGTASTVRDMDAVRTALGEDQINYLGFSYGTELGAAYAEQYGDRVRTMVLDGAVDPSIDPITKNIRQMAGFQKAFESYAADCAKAQGCPLGTDPAQFVSRYQQLVDPLVARPGSTSDPRGLSYQDANTGTVNALYSARYWPYLTSGLLGLQRGTDAGDLLLLADDYQNRDDAGRYQNLQDAFTAIRCVDAPYPTDPAVWADADRRIREVAPFLAYGAFTGYAPRDVCALWPVQPTSVPHQVRGPGPGKVVVVSTTGDPATPYQAGVDLARQMGAALISFDGSQHTVVFNGDACVDTAVLNFFVNRQSPGNLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFN2</accession>
    <name>A0A132PFN2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_27305</name>
        <name evidence="10" type="ORF">AWC31_07240</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855401.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07240"/>
    <dbReference type="EnsemblBacteria" id="KWX21084">
        <property type="protein sequence ID" value="KWX21084"/>
        <property type="gene ID" value="AFM11_27305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09983">
        <property type="protein sequence ID" value="ORX09983"/>
        <property type="gene ID" value="AWC31_07240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3336"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="8">
        <location>
            <begin position="12"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX09983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="547" mass="60433" checksum="07A568589028E3B0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFY8</accession>
    <name>A0A132PFY8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_26685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855052.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22650"/>
    <dbReference type="EnsemblBacteria" id="KWX21240">
        <property type="protein sequence ID" value="KWX21240"/>
        <property type="gene ID" value="AFM11_26685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3208"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05150">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024165">
        <property type="entry name" value="Kan/Strep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000706">
        <property type="entry name" value="Kanamycin_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="5">
        <location>
            <begin position="138"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000706-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000706-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="26671" checksum="7F4937C54D53C2E2" modified="2016-06-08" version="1">MTIPVGDVPIPAIVLDIAAGRATKAVWDNEVGGQTFEIGHGDAREFVKVAPPHPSVDLHREAIKLRWARQYLTVPPVLDVGRDGATEWLHTAGIAGRSAADPYWIARPRLAVRAIATGLRAMHERAPVDRCPFSWSVPERLANIDDAARRRLPDAPPIDRLVVCHGDSCAPNTLLDDDGRWCGHVDLGELGVADRWADLAVATLSLGWNYAGDWEAEFFGAYGVTPDPVRIDYYRRLWNAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGJ4</accession>
    <name>A0A132PGJ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854030.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27090"/>
    <dbReference type="EnsemblBacteria" id="KWX21446">
        <property type="protein sequence ID" value="KWX21446"/>
        <property type="gene ID" value="AFM11_24835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2328"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="267"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="512" mass="53465" checksum="35191A0D08B9063A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGM1</accession>
    <name>A0A132PGM1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_25195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854201.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27515"/>
    <dbReference type="EnsemblBacteria" id="KWX21508">
        <property type="protein sequence ID" value="KWX21508"/>
        <property type="gene ID" value="AFM11_25195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2400"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453321" evidence="9">
        <location>
            <begin position="23"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="37"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX21508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="28595" checksum="3B9A7BDD4B439912" modified="2016-06-08" version="1">MRRLFAAAALALGAIVSAPAVAAQPAVEPAGAQAIADGPAKAWLVADLDTGRVLASKDPYGSYAPASTIKPLLAMVVLDHLRPDNFARANESHTKVECSCVGLEPGRPYTTRQLLEALLMVSGNDAANMLADMLGGQRATVAAMNRKAAAVGARNTRASSPSGLDGPGWESITTPHDLAVIFRAALKYPLIAHTMRQPSAQFPGKTITNQNELLTRYPGDIGGKTGYTNLARKTYVGAAQRGNRRLVVVQMYGTGDLYGQAINLFDYGFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGT2</accession>
    <name>A0A132PGT2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_25375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854289.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27695"/>
    <dbReference type="EnsemblBacteria" id="KWX21540">
        <property type="protein sequence ID" value="KWX21540"/>
        <property type="gene ID" value="AFM11_25375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2437"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="6">
        <location>
            <begin position="385"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="719" mass="76986" checksum="D4C05C548A12C67D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGU0</accession>
    <name>A0A132PGU0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_25060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854134.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27380"/>
    <dbReference type="EnsemblBacteria" id="KWX21484">
        <property type="protein sequence ID" value="KWX21484"/>
        <property type="gene ID" value="AFM11_25060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2373"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="194" mass="20975" checksum="BE953BE446B3501A" modified="2016-06-08" version="1">MPTAATSPSARQAELLEAAYRYALTHGLGEMSLRPLAAAIGSSPRVLLFLFGSKDGLVRALLARARSDELALLDRLRRAADTEPIGLGAAVEETWKWLAADEHRPLLKLWAEAYARSLSEPDGPWGGFARATVEDWLDVLANCQPTQDKTSADGIARRTLALAVLRGGLLDLLATGDRDRVTSAVRAQTAQFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGV8</accession>
    <name>A0A132PGV8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26645</name>
        <name evidence="2" type="ORF">AWC31_22690</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855029.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22690"/>
    <dbReference type="EnsemblBacteria" id="KWX21232">
        <property type="protein sequence ID" value="KWX21232"/>
        <property type="gene ID" value="AFM11_26645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15400">
        <property type="protein sequence ID" value="ORX15400"/>
        <property type="gene ID" value="AWC31_22690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3200"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX15400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="228" mass="24857" checksum="80D54C2750303DC5" modified="2016-06-08" version="1">MSGRLVLVRHGQSLANVERRLDTRPPGAELTDLGRDQARSFASTLSNRPLIVAHSQARRAAQTAAGIAEETGLTPYEFDGVHEVQVGELEDRNDDAAIAQFNAIYQRWHEGELDVPMPGGESASQVLHRYVPVVTQLRMRYLDDHAFDGDIVLVSHGAAIRLVAAVLAGVDGSFALDHHLANAQSVVLAPITDGRWSCVQWANLTPPFYPELDVHPVEDALKSNDPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGZ6</accession>
    <name>A0A132PGZ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853474.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21583">
        <property type="protein sequence ID" value="KWX21583"/>
        <property type="gene ID" value="AFM11_23895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2137"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="83" mass="8845" checksum="DC1F122E6B35C398" modified="2016-06-08" version="1">MSQSPAQGLIDEVAPGDIVALDRGTGERAYKVVHKESTASGFLITFEGNDGETFQNEIAAGTPVKRSLESKWESAQSPTPHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGZ7</accession>
    <name>A0A132PGZ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_24090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853583.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24030"/>
    <dbReference type="EnsemblBacteria" id="KWX21615">
        <property type="protein sequence ID" value="KWX21615"/>
        <property type="gene ID" value="AFM11_24090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2177"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="233" mass="26187" checksum="AC38413ACF7A1840" modified="2016-06-08" version="1">MAEERICMSPSALVGRPDEPTATGPARDRVYEWLRDEIIRGTLEGGMFLDEQWVSRTMGVSRTPVREALHRLAAEKFVTLNPRKGAQVRMVTARELEEVYQARLLIEGNAINTTCARNGSAAEDMANFLEPMEQAGRERDWFTVAHLDREFHLTLVRAAGNSVLTELYDSLRSRQQRLAVRMLHVGPQRLDTINAQHRALVAALGKCDAAESLRILQEHLQPVPEVVVLLPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH77</accession>
    <name>A0A132PH77_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="10" type="ORF">AFM11_25890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854566.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36005"/>
    <dbReference type="EnsemblBacteria" id="KWX21352">
        <property type="protein sequence ID" value="KWX21352"/>
        <property type="gene ID" value="AFM11_25890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3042"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="434" mass="44510" checksum="335887F03B4BBF1C" modified="2016-06-08" version="1">MSGHDEQKAAWAAPSTTTPVDATVTVPGSKSLTNRALILAALATPQGTSTVSGALRSRDTDLMIEAIRTLGVTVTGDGSALTVGGAIAPAPDARVDCGLAGTVLRFVPSVAALSTASVTFDGDEQARARPIAPLLDGLRNLGVDVDGDGLPFVVRGSGAVSGGTVEIDASGSSQFVSGLLLSGASFTDGLTIVHTGESVPSAPHVAMTVAMLRDAGVDVDDSVANHWHVDPGPIAARAWNIEPDLSNATPFLAAALVTEGTVRIAGWPTVSIQPADTILDLLTKVNASVRQVDSHLEVTGAEEYDGFDADLHDVGELAPTVAALAALAREGATSRLRGIAHLRGHETDRLAALTAEINGLGGDCAETEDGLLITARPLHGGTWRSYADHRMATAGAIIGLRVPGVEVENIETTAKTLPDFPLMWVNMLADSPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHE5</accession>
    <name>A0A132PHE5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853927.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21733">
        <property type="protein sequence ID" value="KWX21733"/>
        <property type="gene ID" value="AFM11_24430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2246"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="56"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="197" mass="21680" checksum="D0E462ACC86C9178" modified="2016-06-08" version="1">MTEYHPHFVGNRHDYLPAAGHDLLLPAYDLLTRVLGMGRVYATLVDDADLQPGQRVIEIGCGTGNLTTRAKRSSPGSEFAATDPDPRALRRARRKAKGLTGIRFERAYAQQLPFGDGEFDRALSSMMLHHLDDATKAAAAAELLRVLKPGGLLHIVDVRGDAIPRVLEAAGFDCATTRAERHRVIGQITYYRATRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHG5</accession>
    <name>A0A132PHG5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23120</name>
        <name evidence="2" type="ORF">AWC31_27885</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853023.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27885"/>
    <dbReference type="EnsemblBacteria" id="KWX21753">
        <property type="protein sequence ID" value="KWX21753"/>
        <property type="gene ID" value="AFM11_23120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14962">
        <property type="protein sequence ID" value="ORX14962"/>
        <property type="gene ID" value="AWC31_27885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1976"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX14962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="160" mass="17361" checksum="E1D1B8EC6DCB8A4F" modified="2016-06-08" version="1">MALFLRKLLRIGGLPGDLRAEAESEGILFIAEYVPVTRRFTGSIPGKRSAGSIASYAGSLVLTNHRVLATMSTIPKLAGRSIDQPWAAPQSGAVKAELSTSGLTLETDLAEVDPRCQGQLSMHYKTEIPEDVLMRVPLRSLAFDVPPEYVFRAIGVPYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHG7</accession>
    <name>A0A132PHG7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21780">
        <property type="protein sequence ID" value="KWX21780"/>
        <property type="gene ID" value="AFM11_23280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="77" mass="8584" checksum="AD75F6B3E23ED26B" modified="2016-06-08" version="1">MAVRLSLDVDHLWIDGVQPSPEHVTDDIDIGAFNCELEDLRPTNFAQMISNKTPVVIEIGLLVLLAIRHIALSFQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHH0</accession>
    <name>A0A132PHH0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_24060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21714">
        <property type="protein sequence ID" value="KWX21714"/>
        <property type="gene ID" value="AFM11_24060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2171"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453292" evidence="6">
        <location>
            <begin position="18"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="390" mass="40276" checksum="1F0442660CA8C0C2" modified="2016-06-08" version="1">MLLIAVSTFLAMSVWFSASFVAPQLVESWQLSTAGSSLLTIAVQLGFVVGAVASAATGLADAVAPRQLICVGAVGAAAANLALLWANGLVTALPLRLLTGIGLAMIYPPALKEVSSWFRVGRGTALGVMIGALTLGSALPHLVSSFGDVPWQQVIVATTVMTLAGGLLILLLRGPGPYPFPNRPFSFAAAFASLRNKNVALANVGYIGHMWELYAMWAWVGAYLAALPAIAGRQNSQATAAALAFVCIGAGAIGCLVGGRLSDRFGRAQSALISLVCSGLAALVLSLLGTGPLWIVVPLCVFWGFWVIADSAQFSALVTEHADPVYVGGAVSIQLALGYLTTTMSVWLVPVLVQRWSWSAALAVLAVGPAVGATAMLILSRSQKSSLTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHQ5</accession>
    <name>A0A132PHQ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853404.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28175"/>
    <dbReference type="EnsemblBacteria" id="KWX21880">
        <property type="protein sequence ID" value="KWX21880"/>
        <property type="gene ID" value="AFM11_23450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2045"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="309" mass="33096" checksum="2E211D5BC586DA0B" modified="2016-06-08" version="1">MDFRVFVEPQQGATYSDQLAVAKAAEALGYSAFFRSDHYLAMSGDGLPGPTDSWVTLAGIARETSTIRLGTMVTSATFRYPGPLAIAVAQVDEMSGGRVELGLGAGWFEEEHQAYAIPFPPLGERFDRLTEQLRILTGLWNTPVGETFDFSGTHYTVVNSPALPKPTQTPLPIIVGGQGAKRTPALAAEFAAEFNVPFVPLDALKTQFERVAAAVAGAGRSPGSMTYSAAFVVCAGRDDAEIAKRAAAINRDVDELRSNSPFVGTPAEIVDKLAPFTEAGVQRVYLQLLDMADLDHLDLVASEVVRQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHU7</accession>
    <name>A0A132PHU7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_22210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852646.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09000"/>
    <dbReference type="EnsemblBacteria" id="KWX21891">
        <property type="protein sequence ID" value="KWX21891"/>
        <property type="gene ID" value="AFM11_22210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1792"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="251" mass="26932" checksum="C22366417A40076A" modified="2016-06-08" version="1">MMTSSFDEFRTPTAGPAIDITDLQVVRGGRPAVRDVTVQIARGTITGLLGPSGCGKTTLMRCIVGTQIVAGGTVTVLGHPAGSAALRHRVGYVTQNPTIYNDLRVVDNVRYFASLYGTSTAAADNAIRSVGLEDHRTAYCANLSGGQRTRASLACALVAEPELLVLDEPTVGLDPVLRVDLWEQFRRLSERGSTLLVSSHVMDEADHCGDLLLMREGRLLAHTTPARLREDTSCTSLEEAFLTVIRHSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHW9</accession>
    <name>A0A132PHW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21602">
        <property type="protein sequence ID" value="KWX21602"/>
        <property type="gene ID" value="AFM11_24000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="60" mass="6582" checksum="13B3C26566BDCEEC" modified="2016-06-08" version="1">MSDDARSIALFLLVFGRRQFRRDLAGRHTAFAAVVGRTWRFVIGFAGVFTVGPLGVGHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHZ5</accession>
    <name>A0A132PHZ5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_22700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852810.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="9myco-a0a132phz5">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21970">
        <property type="protein sequence ID" value="KWX21970"/>
        <property type="gene ID" value="AFM11_22700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1890"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="501" mass="54177" checksum="3E3972E7B77F6094" modified="2016-06-08" version="1">MHERTVRAEISTGIIEGFTRDGVHRWRSIPYARPPVGSLRLRAPQPAEPWPGVRYCHGFGYCAPQQRRYTMVGVGKYQPMSEDCLTLNVVAPQSPPEGPLPVMFFVHGGGYILGSSATPIYDGAALARRGCVYVSVNYRLGVLGCMELSSLSTPEHPIDDNLFLRDLVLALQWVKDNIAAFGGDPDNVTIFGESAGAQAVATLLAVPAAKGLFARVISESPASGMVSSAAAAARLAGQFAGLLGSGGDAAATLKTARAAELGRALEQLISRGMTDMPGAFPVGPTYGTEFLPADPVAAMADGSAHRLPLIVGNNADEGRLFTRFLPLLPTNEAMIEKLFADSAPEHRERIVAAYPGYPSSAACVRLGGDFAFGSATWQIAEAHSRHAPTYVYRYDYTPRALRWAGFGATHAMELLAVFDTYRTRYGSMLTAAADRQSARFVSRDVQTRWREFSRTGVPGAGWPGYDADKRAVYVFDRTPRVEYDPDADRRLAWEGFTLAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI37</accession>
    <name>A0A132PI37_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ORF">AFM11_22885</name>
        <name evidence="10" type="ORF">AWC31_08315</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852877.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08315"/>
    <dbReference type="EnsemblBacteria" id="KWX22006">
        <property type="protein sequence ID" value="KWX22006"/>
        <property type="gene ID" value="AFM11_22885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10164">
        <property type="protein sequence ID" value="ORX10164"/>
        <property type="gene ID" value="AWC31_08315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1930"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX10164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="81" mass="8956" checksum="532C8D46D66BF13C" modified="2016-06-08" version="1">MGGLQPWHWVIVIAVFVLLFGAKKLPDAARSLGKSMRIFKSEIKEMQSESKAEEAAPAKPITSERVETPAPEQQSPDRHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI55</accession>
    <name>A0A132PI55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852919.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08195"/>
    <dbReference type="EnsemblBacteria" id="KWX22026">
        <property type="protein sequence ID" value="KWX22026"/>
        <property type="gene ID" value="AFM11_23015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1954"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453099" evidence="1">
        <location>
            <begin position="41"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="167" mass="16257" checksum="058E4A65CF8DDCF7" modified="2016-06-08" version="1">MTPKTLVTGFITAASAAAVVGGAAAGVTSIASSGMSSAPAVQPVVFGAPLPQLPAPDLEAPLVQTLQALAGGGSFKGKAPYIQGGIGRVESIAADRAYNQAAAEGKFPLTFVVANINQEGGVAYADVTATAATGGTATQNIQFVAGPSPTGWQISKGSALSLLSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI72</accession>
    <name>A0A132PI72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate/phosphite/phosphonate binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08920"/>
    <dbReference type="EnsemblBacteria" id="KWX22035">
        <property type="protein sequence ID" value="KWX22035"/>
        <property type="gene ID" value="AFM11_22290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1808"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005770">
        <property type="entry name" value="PhnD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01098">
        <property type="entry name" value="3A0109s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="278" mass="30118" checksum="607F196A575BDFCA" modified="2016-06-08" version="1">MTVGCSSPSSDSAQPGTVRMAVTDLQGLEELQREFGAFEKEFEKQSGLNLEFFAVTDRTAAAAALEADRVDVVFTGPAEYVVIHERTGAQPIVAIERDGYHSCIYTKADSGITELGQLRGKKVAMSDVGSTSGHLGPSQMLVDAGIEPTSELEVLTVGDAVHESLKRGDVAAVGIGYHDYEEFMGTDDPAQYRMLAEGPTLPPDLLMGRDGLDEQTVTTIRDTFNEHFDTLLPAMLEGKDNAKYENAKLVSVTDADYDEVRSMYRAVGVDDFSEFLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI86</accession>
    <name>A0A132PI86_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfonate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_22720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852818.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08485"/>
    <dbReference type="EnsemblBacteria" id="KWX21974">
        <property type="protein sequence ID" value="KWX21974"/>
        <property type="gene ID" value="AFM11_22720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1896"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="245" mass="26394" checksum="226FBC9F56B3F44D" modified="2016-06-08" version="1">MTVISDRTTKVAGELRGVNKWYGEHHVLSDVSVRIGGGEIVALIGRSGSGKSTVLRVLAGLSTDHTGERVVSGAPALAFQEPRLFPWRDVRTNVAYGLTRSRISRGQALARAERALADVGLADRADAWPLTLSGGQAQRVSLARALVAEPELLLLDEPFGALDALTRLSMRKLLLDLWREHGFGVLLVTHDVDEAVALADRVLVLEAGRVAHTLDITDARRSPGDPSANTERYRAELLDSLGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIS2</accession>
    <name>A0A132PIS2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852026.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06055"/>
    <dbReference type="EnsemblBacteria" id="KWX22250">
        <property type="protein sequence ID" value="KWX22250"/>
        <property type="gene ID" value="AFM11_20640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1465"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="2">
        <location>
            <begin position="16"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="444" mass="46264" checksum="D759E807232908F5" modified="2016-06-08" version="1">MSSSGQVPHPGATDPVVIVGMALEAPGGIETADQYWALLSEQREALGRFPADRGWAIGDLLDGSRRDGFKPIHDLGGFLSSAATFDPAFFGISPREAVAMDPQQRVALRMAWRALENSGINPDDVAGHDVGCYIGASYLEYGPELAEFSHHSGHLITGTSLGVISGRIAYTLDLAGPALTIDTSCSSALTAFHTAVGAVRAGDCDMALTGGVCVMGTPGYFVEFSKQHALSDDGHCRPYSAHASGTVWAEGAAMFVLQRKSAAVRDRRRILAEVRATTVNQDGRTTGLTAPSGAAQQRLFSKAIEQAGVRPEDVGMIEGHGTGTRLGDRTELRSLVQTYGATDPGAGAVLGSVKSNVGHSQAAAGGLGLAKVLIAAQRAAIPATLHVDEPSREIDWDSQGLRLATKLTQWPAVNNERIGAVSAFGMSGTNAHAIVAVPDDGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIU7</accession>
    <name>A0A132PIU7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_22450</name>
        <name evidence="9" type="ORF">AWC31_08760</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08760"/>
    <dbReference type="EnsemblBacteria" id="KWX21932">
        <property type="protein sequence ID" value="KWX21932"/>
        <property type="gene ID" value="AFM11_22450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10238">
        <property type="protein sequence ID" value="ORX10238"/>
        <property type="gene ID" value="AWC31_08760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1840"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="56"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX10238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="171" mass="19275" checksum="676EFD9CDC961918" modified="2016-06-08" version="1">MRIEDALRVAADADLDLVEVAPDAKPPVCKIMDYGKFKYETAQKARESRKNQQQTVVKEQKLRPKIDPHDYETKKGHVIRFLEAGSKVKVTIMFRGREQSRPELGFRLLQRLGADVADYGFIETSAKQDGRNMTMVLAPHRGAKTRAKAAEQAERPVGQQATPEEPDVSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ37</accession>
    <name>A0A132PJ37_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Damage-inducible protein DinB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852938.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08165"/>
    <dbReference type="EnsemblBacteria" id="KWX22032">
        <property type="protein sequence ID" value="KWX22032"/>
        <property type="gene ID" value="AFM11_23045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1960"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="55"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="168" mass="18967" checksum="048ED1F159966F79" modified="2016-06-08" version="1">MIDALRRQFELAWALADLHLASLTADDFLWAPAPLVWTVHQDASGRWYPDLADTEPDPIPVPTIGWLTWHMIFWWSTALAHLTDRVPPQRIEIDWPGPTASVERIRTLATQWRDLLDSLTAADLAAAADFPWGEGSGRTVADTVLWLHVELTKNAAEIGQLRMLRAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJD0</accession>
    <name>A0A132PJD0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_20035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851888.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28480"/>
    <dbReference type="EnsemblBacteria" id="KWX22446">
        <property type="protein sequence ID" value="KWX22446"/>
        <property type="gene ID" value="AFM11_20035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1343"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX22446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="209" mass="22700" checksum="8E7FEA4958E1AE33" modified="2016-06-08" version="1">MEDAPAPQGRSAVSGGAASARDRVVTVPNALSLVRLVLVPVFLYLLFVAHAQGWAVAVLMFSGFSDWADGKIARLVANQSSRLGELLDPLVDRIYMVTVPVALAFYGAVPWWIVLTLLGRDAVLAATLPILRSRGLAALPVTYIGKAATFALMSGFPLILLGQWDALWSRVILACGWAFLIWGLALYLWSAVLYLIQVVLVVRRMPVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJV9</accession>
    <name>A0A132PJV9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851652.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15280"/>
    <dbReference type="EnsemblBacteria" id="KWX22630">
        <property type="protein sequence ID" value="KWX22630"/>
        <property type="gene ID" value="AFM11_19210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1176"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="445"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="507" mass="54262" checksum="F91F93846491A398" modified="2016-06-08" version="1">MVTLDRLINVLGGYGVHLQYCSTSRSTELRSVVMHEPGQVIGDVLLAVGAASAAEAIEWAAAARAVVVLVRSDAEPDDGTVPGEPDRIAVMAVDPEVSWSDLAAVVYGLVLEGRETESGRGPTDLFALADSLAEAVGGAVTIEDRHSAVLAYSRLQQHADPARAETILSRQAPERLRAVFAERGVFRHLAESDDPMFVDGDADHGLTGRMVVAARAGRELLGSVWVASAEPLRDGRRTALADGARMVAMHLLRSRASADLERQVESELVIRLLEGAADATTVASRLALPQTPLRVIALRAHTTDERHAALLLAFERATAGFGWSRPGRSALAGNTVYTVLPGAEPAAARAWAAGLRAALPEPVTVLAGVSGPATVAELALARREADECLALHEVRRGGAVPVYDEAWDDILLQRLRIAAQSGRAPKRGPVAELREHDRANGTQYAHTLRAWLEAQGDLAEAGRELGVHENTVRYRLRKMAEVTTLDLDDARKRLAMMIELAASEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK26</accession>
    <name>A0A132PK26_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851783.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15690"/>
    <dbReference type="EnsemblBacteria" id="KWX22700">
        <property type="protein sequence ID" value="KWX22700"/>
        <property type="gene ID" value="AFM11_19625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1258"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="46"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="330" mass="36268" checksum="E56E32CC854E178C" modified="2016-06-08" version="1">MTTVTIPMHDDPVSFDSAAELADALREQDYIADTDLATVVHLATALDRPLLLEGPAGVGKTELAKALAAAGGRKLVRLQCYEGLDDNRVLYEWDYAKQLLHVQMLRDRIAADASAIDEIAANLYTEDFLSVRPLLESVLSEQPVVLLIDEVDRTEEAMEALLLEVLAERQITIPEIGTFVARTVPWVVLTSNDTRELSAALKRRCLHFHLDFPTPQRERDIVGVRAPHVEPAVVADVVELARTLRELPLRKSPSISEVIDGARAAALLGGEVPQELLLSTLVKFTSDRDIALRHLTQTPTVATEVHERVTVASRPANTTTAAFRGRGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK89</accession>
    <name>A0A132PK89_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiocyanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitrile hydratase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851748.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15560"/>
    <dbReference type="EnsemblBacteria" id="KWX22674">
        <property type="protein sequence ID" value="KWX22674"/>
        <property type="gene ID" value="AFM11_19475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1228"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036648">
        <property type="entry name" value="CN_Hdrase_a/SCN_Hdrase_g_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004232">
        <property type="entry name" value="CN_Hdrtase_a/SCN_Hdrlase_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023900">
        <property type="entry name" value="CN_Hdrtase_asu/SCN_Hdrlase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023901">
        <property type="entry name" value="Thiocyan_Hydrolase_gsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02979">
        <property type="entry name" value="NHase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001426">
        <property type="entry name" value="NHase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56209">
        <property type="entry name" value="SSF56209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03887">
        <property type="entry name" value="thiocyan_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHase_alpha" evidence="4">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001426-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="236" mass="26682" checksum="977CDA6997EBB648" modified="2016-06-08" version="1">MSDHHDHDHDHDRTVKPMVDEITDFEVLEIALRELCIEKGIFTAEEHRHFTEFAEQIGPTPAARLVARAWLDPDFKQLAVTDALAASKEVGVDWLEPTGFGTPSDFVAFKILEDTPTLHHVIVCALCSCYPRPILGNSPEWYRTPNYRRRLVRWPRQVLAEFGLYLPDDVAVRVEDSNQKHRFMVMPVRPDGTEGWSEDQLAEIITRDCLIGVALPKPGVTTNVIVDTRAAIHPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKI1</accession>
    <name>A0A132PKI1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Na(+)/H(+) antiporter NhaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sodium/proton antiporter NhaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaA</name>
        <name evidence="9" type="ORF">AFM11_18105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851264.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12175"/>
    <dbReference type="EnsemblBacteria" id="KWX22846">
        <property type="protein sequence ID" value="KWX22846"/>
        <property type="gene ID" value="AFM11_18105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.978"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0050">Antiport</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="430" mass="45404" checksum="ECFF6A5D34EF47DB" modified="2016-06-08" version="1">MTSPPDRTRPRLLTRTTWPEWQRVSELLRAETVGGALLLAAAAAALVWANSPWSASYDRLSNFVIGWESLHLELSVSAWAADGLLAIFFFVVGLELKREFVAGDLRDPARAALPIAAAVGGMAAPAAIFIGINLFAGQPENIDGWAVPIATDIAFALAVLAVLSTHLPSALRIFLLTLAVVDDLLAIIVIAVFYTDHLSVGPLLGAVVPIALFGLAVQRGYRQWWILVPLAVVAWALAHASGVHATVAGVLLGFTVPVLGRHAAAERFEHRLRPLSAGVAVPVFAFFAAGVTVGGLSGFATALTHPLTIGVIAGLVLGKPIGIFCTTYLLARFTNASLDEDLAWRDVFGVALLAGIGFTVSLLIGELAFEDSPVADADVKIAVLTGSVVAGLLAAVVLISRNVVYRRIHILETTDADSDGVPDIYQPRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKM0</accession>
    <name>A0A132PKM0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_18515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851355.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22886">
        <property type="protein sequence ID" value="KWX22886"/>
        <property type="gene ID" value="AFM11_18515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1037"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="235" mass="25746" checksum="19525492D78E9738" modified="2016-06-08" version="1">MPTGRPNPPTRRERLHAETSREIKSIALQQLAQYGAGGISLRGIASEMGMTARAIYTYFPTRDDLITALIDDITTELADTLESARDSKRSTGSRLVAWGIALREWAMTHPAEFRLIYGDPIPGYVPPPDGPGVRAAQRICGGLNRLVAEEVSAAHPDLSSTVRWSQFPPDYADKVRAEVPDASPALAALTLRVWGRMHGLITLEVYGHLRAVCNDPAAIQRADLAEIVRDLRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKN6</accession>
    <name>A0A132PKN6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851409.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05095"/>
    <dbReference type="EnsemblBacteria" id="KWX22910">
        <property type="protein sequence ID" value="KWX22910"/>
        <property type="gene ID" value="AFM11_17575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.870"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="11"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="162" mass="16389" checksum="139EE446AB06E892" modified="2016-06-08" version="1">MDDPLVTDDARALVADLTVRGQSVATAESLTAGLLAATLAGVPGSSAVLHGGLITYTEDTKIWLAGVAPQVLDAVGPVAGPTARALAVGARQRCAATWGVSLTGVAGPEAHGGHPPGTVFLGLAGPVDTEVVELALTGSRWEIRRAAVNEAVARLRALVERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL34</accession>
    <name>A0A132PL34_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_18585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851386.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12610"/>
    <dbReference type="EnsemblBacteria" id="KWX22897">
        <property type="protein sequence ID" value="KWX22897"/>
        <property type="gene ID" value="AFM11_18585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1054"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="281" mass="29382" checksum="FC6968D211D1D746" modified="2016-06-08" version="1">MTLTEALPAIRIPRIRRIDVGIADLVPLLFLALVAAMIVAPGAIAPYDPLQENPELPLAGPSLAHPFGTDYIGRDLLSRVVAGTGATIAGSFIAVVIGLVVGTILGLLAAYFGRATDSVISRIVDVLLSIPTLLLSITIIVALGFGTVNAAIAVGVSSIAVFARLARSEVLEIRNLPFVEASEHLGAGHLALLFRHVLPNSYSAVLSLAALQFGTAILAIASLSFLGYGAQPPEPEWGLLISEGRNYINSAPGLVFFPSIAIVLTVMSLSRLAHLVRMKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL83</accession>
    <name>A0A132PL83_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850729.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23014">
        <property type="protein sequence ID" value="KWX23014"/>
        <property type="gene ID" value="AFM11_16720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.696"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453156" evidence="2">
        <location>
            <begin position="38"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="423" mass="42299" checksum="3957F3F6B0C028AA" modified="2016-06-08" version="1">MQVAARSYLAAGVALVGASAIAISPVAPPIPDVTVSAISSPQVELSASANPLEAYLALVTNTVTNVGATISAELDDPAPVLRQIIANQLATAESLFEGLQGAGEGLINVLDPANPYGIPAQLQLALSDLLEGDINGAVANAWSAFLSPVLNVGLPLLEPIINAVKQPVQNTLNILNNPLIVVMPLLGAINVAYTTITVAGNVGQDIVDSLKNGDPLGVVNAILSGPAVITDAFLNGNELGGGIFGPNLGLLSSLRQAREALAAAIKPPVEAPSAAADATLDSAAKVVTLDVAPAETADAATTSTETAVTGGTEETSASAPESDATAPAEEVEAPAAETASPVATDVVKDSPVAVPGKTGTITKSDRANPLKQVRDNIRNTVKNVSDGFKKAAEGLSGKSTKSKTESSSSSSDSGESSGSSDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL94</accession>
    <name>A0A132PL94_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850848.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01630"/>
    <dbReference type="EnsemblBacteria" id="KWX23073">
        <property type="protein sequence ID" value="KWX23073"/>
        <property type="gene ID" value="AFM11_17060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.765"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="359"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="428" mass="46593" checksum="1D498C6A4831A736" modified="2016-06-08" version="1">MAAVNRVYAARLAGLVVLGPDGESIGRVRDVVISISIVRQQPRVLGLVVELLTRRRIFVPILRVTAIEPGSVTLATGSVSLRRFAQRPGEVLVLGQVLETRVKVVDPDLPELSGIDVVVVDLGIEQTRTRDWMVTRVAVRPQRRLGRRSNIHVVDWQNVHGLTPSGLAMPDQGVASLLEQFEGQRPVEVAEALRELPAKRRYELFRAFDDERLADVLQELPEDEQAEVLQQLNTERAADVLEAMDPDDAADLLGTLTPADAEVLLGRMDPEDSEDVRRLLSHSPDTAGGLMTSEPVVLAPDTTVAEALARVRDPDLTPALASLAFVARPPTATPTGHYLGCVHLQRLLREPPATLVSGIVDVDLPTLGPQDSLAAVTRYFAAYNLVCGPVVDAESHLVGAVSVDDVLDHLLPDDWRERDEPELPVTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLE6</accession>
    <name>A0A132PLE6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_15170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15790"/>
    <dbReference type="EnsemblBacteria" id="KWX23168">
        <property type="protein sequence ID" value="KWX23168"/>
        <property type="gene ID" value="AFM11_15170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7146"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="46"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="771" mass="84487" checksum="DC4CC499BB6CD3AD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLH9</accession>
    <name>A0A132PLH9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851021.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01510"/>
    <dbReference type="EnsemblBacteria" id="KWX23153">
        <property type="protein sequence ID" value="KWX23153"/>
        <property type="gene ID" value="AFM11_16940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.741"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="30766" checksum="ACCA7E3E4D049A0D" modified="2016-06-08" version="1">MLSTFCGRPVAGDRALIMAIVNRTPDSFYDRGATFTDEAAKAAAARVIDEGADVIDVGGVKAGPGHGVDTQEEIARVVPFIEWLRTTYPNQLISVDTWRAAVAKQACAAGADLINDTWAGADPGLPEVAAEFGAGLVCSHTGGAVPRTRPFRVNYGITERGVVDDVIAEVTAAAERAVATGVPRDRILIDPTHDFGKNTYHGLTLLRHVKDLVKSGWPVLMALSNKDFVGETLGVDLTERLEGTLAATALAAADGAAMFRVHEVGPTRRVLEMVASIQGVRTPARTVRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLR0</accession>
    <name>A0A132PLR0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850354.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15980"/>
    <dbReference type="EnsemblBacteria" id="KWX23276">
        <property type="protein sequence ID" value="KWX23276"/>
        <property type="gene ID" value="AFM11_15785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7281"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="376" mass="40356" checksum="BF1D2C753081BA65" modified="2016-06-08" version="1">MSTKPPALDMGAILSDTANRVVVCCGAGGVGKTTTAAAMALRAAEYGRTVVVLTIDPAKRLAQALGIKDLGNTPQRVPLAPEVTGELHAMMLDMRRTFDEMVVQYSGPDRADAILENQFYQTVATSLAGTQEYMAMEKLGQLLAEDKWDLVVVDTPPSRNALDFLDAPKRLGSFMDSRLWRMLLAPGRGIGRLVTGAVGLAMKALSTVLGSQMLSDAAGFVQSLDATFGGFREKADRTYELLKRRGTQFVVVSAAEPDALREASFFVDRLSSERMPLAGLILNRTHPTLCDLHADKAEEAADELAAEDPESLPAAVLRIHADRAQTAKREVRLLSRFTGANPHVAIVGVPSLPFDVSDLEALRAIADQITGVAEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMK3</accession>
    <name>A0A132PMK3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_15765</name>
        <name evidence="5" type="ORF">AWC31_16000</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003883807.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16000"/>
    <dbReference type="EnsemblBacteria" id="KWX23272">
        <property type="protein sequence ID" value="KWX23272"/>
        <property type="gene ID" value="AFM11_15765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17915">
        <property type="protein sequence ID" value="ORX17915"/>
        <property type="gene ID" value="AWC31_16000"/>
    </dbReference>
    <dbReference type="GeneID" id="44296491"/>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7276"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX17915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="224" mass="24791" checksum="98EC2E1A8B1105A3" modified="2016-06-08" version="1">MDEILARAGIFQGVEPTAVSALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRSPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRAWIADRPEIAEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMN0</accession>
    <name>A0A132PMN0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850034.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17770"/>
    <dbReference type="EnsemblBacteria" id="KWX23575">
        <property type="protein sequence ID" value="KWX23575"/>
        <property type="gene ID" value="AFM11_15070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7125"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="262" mass="27215" checksum="6410256BD8121F07" modified="2016-06-08" version="1">MDYLLSGKTAIVTGGASGIGLETANQLLAEGTNVLAVDLDVDSLAARQDPQLRSFQCDLTDPDSASAATAAALEAFGSIDVLISCAGIAPVRSSSLEGTDADWRRTLDVNFLSIVRMCREVVPHMKAANGGSIVSVASDAGRMPDPFFAEYNVSKAAILMFMKALSIEFGGAGIRANTVSPGPVRTPMWDRPGGFGDSVAESFGMEKEAAIEHFAVNVRKLPLARLGTVAEVAAVNVFLASPLASFVTGAEYTVNGGSIPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMN3</accession>
    <name>A0A132PMN3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalt transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850410.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16525"/>
    <dbReference type="EnsemblBacteria" id="KWX23302">
        <property type="protein sequence ID" value="KWX23302"/>
        <property type="gene ID" value="AFM11_15950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7315"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012666">
        <property type="entry name" value="CbtA_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09490">
        <property type="entry name" value="CbtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="27165" checksum="8225D5C3ED6B8889" modified="2016-06-08" version="1">MEKRIIGRGLLAGALGGLFAFIFARIFVEPVIDRAIAFEESGGEAHAHTHDHGAAAGGAHEHGVELISRGVQANIGLGFGVIAFAVAMGALFAVAYCVAYGRVGAISPRLLSVLLAGGMFVSLYVVPSLKYPANPPAVSLDETIQQRTLLYLLMVVVSAALLVAAVYLGRQLVSRFGTWNATLLAGGAYIVAMAVVMLVLPTIDETPGAFPADDLYEFRLYSLLTQLVMWATIGLVFAPLAARLLGEAPSRRQADIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMS6</accession>
    <name>A0A132PMS6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_14705</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850092.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18195"/>
    <dbReference type="EnsemblBacteria" id="KWX23603">
        <property type="protein sequence ID" value="KWX23603"/>
        <property type="gene ID" value="AFM11_14705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7050"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453427" evidence="13">
        <location>
            <begin position="18"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="14">
        <location>
            <begin position="77"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX23603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="456" mass="46160" checksum="57EA3B91516A5AB5" modified="2016-06-08" version="1">MVLLIIAGTAGAGTAFAVEPPVVPPGPAPAGPVAPPDPTEQKTVCAVGGSRPQTDYRLAPIAQAMLHYRDAWAYSRGAGQTVAVIDTGVNPHPRLPVLQPGGDYVSGTDGLSDCDAHGTLVAGIIAAAPSADDAFAGVAPDAAILAIRQNSLSFAVKGGRQSYDPNSVSPGTGAAGYGNTHTLALAVTRAVDLGATVINLSVLACAPSGIGIDDADLGRAVRYAFDRNVVVVAAAGNVDKQGPCGAQNTMADPNLPVDTAWPDVRTVASPAWFDDYVLTVGSLSPYGEPSDFSLNGPWVDVAAPGEQVVSLDPNGPGLINGIPGQNGLAPINGTSYAAPYVAGVAALVRARFPELSAAQVMERIERTARTPGAGPNIASGYGVVDPVAALTADLVTQDVDDARGTPIAGPPAPGPDANRARNIAFIAAGGCVAAMVFAWALSVAYRRRNAEQSENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMU9</accession>
    <name>A0A132PMU9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848962.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02825"/>
    <dbReference type="EnsemblBacteria" id="KWX23633">
        <property type="protein sequence ID" value="KWX23633"/>
        <property type="gene ID" value="AFM11_12565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6603"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="234" mass="25487" checksum="764CEE653AB65D8E" modified="2016-06-08" version="1">MDVPERDPETPDAPVNRLQKRKLKTRSALIRAAQRFIAEGRLNVPILDITQAADVGMGSFYNHFSSKEELFDAAVADALDNLGALLDGFTGSMEDPAEAFAVNFRLTGRLFRSRPEEAALLLANGGSLILSDRGLSPRALRDIAAAIERHRFTIADAELGLAIAGGMLVGLTTLLRERPQRDTDATVDEVTERLLRTLGMTPHQARAMCRKPLPVISALHDPPADWPTPMSPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN69</accession>
    <name>A0A132PN69_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13535</name>
        <name evidence="3" type="ORF">AWC31_03780</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849423.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03780"/>
    <dbReference type="EnsemblBacteria" id="KWX23788">
        <property type="protein sequence ID" value="KWX23788"/>
        <property type="gene ID" value="AFM11_13535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11243">
        <property type="protein sequence ID" value="ORX11243"/>
        <property type="gene ID" value="AWC31_03780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6802"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021678">
        <property type="entry name" value="DUF3263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11662">
        <property type="entry name" value="DUF3263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="103" mass="11893" checksum="39254434F526EFE5" modified="2016-06-08" version="1">MDGAMARTEQSGDDSDLTDGLTRREHDILAFERQWWKYAGSKEDAIKELFSMSATRYYQVLNALVDRPEALAADPMLVKRLRRMRATRQKARAARRLGFDINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNQ1</accession>
    <name>A0A132PNQ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_11330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848173.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23961">
        <property type="protein sequence ID" value="KWX23961"/>
        <property type="gene ID" value="AFM11_11330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6343"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1485"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3580"/>
            <end position="3658"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1519"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="3616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="3669" mass="391996" checksum="4D1D9D97471697FC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNS2</accession>
    <name>A0A132PNS2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849147.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03225"/>
    <dbReference type="EnsemblBacteria" id="KWX23692">
        <property type="protein sequence ID" value="KWX23692"/>
        <property type="gene ID" value="AFM11_12940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6680"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="164" mass="17878" checksum="EFC606BFB21BFEFE" modified="2016-06-08" version="1">MLTEAEGQSGAQAPEVLFYEQGASWAWLLAGPAAGISMAILQRTGGYGHDLWIPLAFLVLVSGFIAIQIKAARIHTSVELTAQTLRQGTERISINEIVRIYPEATGSEALKWQSFRALGELTGVPRGRTGIGLKLTGDRSAQAWARKHRRLREALSALVEERTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP76</accession>
    <name>A0A132PP76_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKS_ER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_12405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848780.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09575"/>
    <dbReference type="EnsemblBacteria" id="KWX24146">
        <property type="protein sequence ID" value="KWX24146"/>
        <property type="gene ID" value="AFM11_12405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6560"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="4"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="353" mass="36709" checksum="16E7A0E87E081DA0" modified="2016-06-08" version="1">MRASVIEQLGTPPVVAEVPDPVCPADGAILRVEANGICRTDWALWSGQFWSGGPVLAAPFVLGHEFAGTIVEVGADVRNWKPGARVTFPMNPGDGTCQTCRTGNQQVCEHFDELVPGVSYWGGYAEYVAVRFADVNLVELPETLSATAAASLGCRYMAAFHGIVEQARTRGGEWVAVHGAGGGMGLAVVQIAAAVGANVIAVDIFDDKLETARALGAVHTVNAAKEDAAGAVRELTSGGAHVSVDAVGIASSCRASVESLRIRGRHVQLGHTTPAERGSIALPIDVMMVKELEFLSAFGMAAHRFPAMLSMVEAGRLDPGKVVSSTVGLDGVGGVLESMAAYGTTGVVVIDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPB5</accession>
    <name>A0A132PPB5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848885.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09640"/>
    <dbReference type="EnsemblBacteria" id="KWX24186">
        <property type="protein sequence ID" value="KWX24186"/>
        <property type="gene ID" value="AFM11_12340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6547"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="136" mass="14976" checksum="CF9DE206506D6F9C" modified="2016-06-08" version="1">MEITINASFLPHTDPEESLAFYRDALGFEVRKDVGYEDMRWITVGPAGRPDMNIVLTPPAADPGITDDERRVIAEMMAKGTYASIMLATSDVDGLFEKVQASGAEVMQEPTDQPWGARDCAFRDPAGNTVRIQELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPI4</accession>
    <name>A0A132PPI4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848879.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09780"/>
    <dbReference type="EnsemblBacteria" id="KWX24184">
        <property type="protein sequence ID" value="KWX24184"/>
        <property type="gene ID" value="AFM11_12195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6518"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="202" mass="21467" checksum="C83B56422897A673" modified="2016-06-08" version="1">MPDAPSKDGPDEAPDRGDGMFTAYGVASAVLGVIAVAAVVLAAMIWSGHRSDVAERNYQTRVLQVAADWTGVLINMNADTVEADMQKLHEGTVGQLNTDFDSAVQPYRDLVQRLKSRTSGQIDSVSIESLYHPPTGPDGAAQPGPPPGLSGMVSRVDTVLVVATSVTENAGTDKPQTVRWTLRLDVSDVDGALMISRLEPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPL0</accession>
    <name>A0A132PPL0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847302.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05410"/>
    <dbReference type="EnsemblBacteria" id="KWX24279">
        <property type="protein sequence ID" value="KWX24279"/>
        <property type="gene ID" value="AFM11_09815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6001"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453466" evidence="2">
        <location>
            <begin position="26"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="46"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="281" mass="29140" checksum="672DC3DCED0D9783" modified="2016-06-08" version="1">MKKFTIALAAACLAVLAGCSSSESAAPSESAGPPKVQPPAILQAGTLKVCAPNDGTPPGVYHDETGNLVGSEVDLANALAGQLGLKAEFVQSGFAAVIPTLQGKQCDVIMAQLYIKPEREKVVDFVPYLYSGTGIAVAEDQATDITGMNDSLCGKKVMVAVGTTAEALSLEQSEKCTAAGKEPVDISRNSNAAVSLQQVQTGQVDAFLDTAETLGYYETKTGAKIQMAGEPFGTIKIGAATLKGNTALHDAIQQALTELQNSGAYDEILAQWGQTDLSIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPV6</accession>
    <name>A0A132PPV6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847618.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18870"/>
    <dbReference type="EnsemblBacteria" id="KWX24376">
        <property type="protein sequence ID" value="KWX24376"/>
        <property type="gene ID" value="AFM11_10435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6127"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="399"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="504" mass="54320" checksum="FF8920A6D8EEDB61" modified="2016-06-08" version="1">MTGVPWQTIPEMVLSAADRFGDAEAVVDGPLRLTFSQLTERVRRAAGAFHGLGIDRGDRIAIWAPNSAEWMIAAFGALTAGAVVVPVNTRFKAEEAGDVIRRSGAKAVLRQQGFLGQEFEVPAGVPAIELKSDFLGSGPAYEAPDLSGTDIADIIYTSGTTGRPKGVMMNHRQTLRLYAEWCDLADLREGDRYLIVNPFFHTFGYKAGCIASLIRGATVLPVPLFDVDAVVELIAAERITMLPGPPTLYHSLLAVPDKTKLATLRAAVTGAADIPVELVRRIHEELPFQTLATGYGLTEAGTATLSRPGDSFEDIATTVGTACDGVEVTVADDGEVLVRGYSVMQGYFDDPAATAEAIDGDGWLHTGDLGTLDDNGRLRIVGRKKDMFIVGGFNAYPAEIEGFLLEHPDVAQAAVIGVDDERLGQVGKAFVVVKQRPGVTRDSVSAEDLIAWSRERMAGYKVPRYVEFLDELPLNATGKVMKDQLQTRLRTGDRSESAERSHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ06</accession>
    <name>A0A132PQ06_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847544.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18715"/>
    <dbReference type="EnsemblBacteria" id="KWX24354">
        <property type="protein sequence ID" value="KWX24354"/>
        <property type="gene ID" value="AFM11_10270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6092"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="268" mass="27923" checksum="021077D3128E3444" modified="2016-06-08" version="1">MPVPAPNPNARAVVTGASQNIGEALATELAARGHHLIVTARREAVLTALAQRLTERYGVTVEVRAVDLADPTARTELCDELSTREISILCANAGTATFGAVKDLDPAGEKAQVQLNVLGVHDLVLAVLPGMVARKAGGILISGSAAGNSPIPNNATYAASKAFANTFSESLRGELKRDGVHVTLLAPGPVRETLPDASEQSLVEKLIPDFLWISTEYTAKLSLDGLEQNKMRVVPGVTSKAMSVASGYAPRAIVTPIVGAVYKKLGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQM2</accession>
    <name>A0A132PQM2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847509.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18645"/>
    <dbReference type="EnsemblBacteria" id="KWX24342">
        <property type="protein sequence ID" value="KWX24342"/>
        <property type="gene ID" value="AFM11_10200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6078"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="30"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="202" mass="22372" checksum="E38F7026CF9ACEC5" modified="2016-06-08" version="1">MTPPSDTYWNHNAAYHPWLVKIAAQRRGDVLDVGCGDGLLAQRLAPVSRSVTAIDPEPAALQRAWLRLADHPDATVTQAGFADFDPGSRRFDLITMVASLHHMDLRGALTKARGLLSPSGEIAVVGLSADKTVRDWLWSALCLPAARAGSWWHRETRDIGVTVAEPAESLDEIRRAADEILPGAKVRRALYYRYLLRWRNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQR7</accession>
    <name>A0A132PQR7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00255"/>
    <dbReference type="EnsemblBacteria" id="KWX24679">
        <property type="protein sequence ID" value="KWX24679"/>
        <property type="gene ID" value="AFM11_08365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5524"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453510" description="DUF218 domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="43"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="192" mass="19779" checksum="FA598095C8436846" modified="2016-06-08" version="1">MGKRLRVALGGAALALAVVCGGAAPSIAQAAPPVASKDFSKPAIVILGYGLKPDGSMRTILYHRVLTGLVIAQSFPQSPIIVTGGNPQNGQTEAGQMRNLLLLLGFPANRIIVEDRANSTVQNAQFSVPLAKKAGTSGIILVTSSTHQGRADQNFADAGGNILATVSFPDGNPSVNITQFVRDVLSPLTPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQY6</accession>
    <name>A0A132PQY6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EspA_EspE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846617.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13575"/>
    <dbReference type="EnsemblBacteria" id="KWX24746">
        <property type="protein sequence ID" value="KWX24746"/>
        <property type="gene ID" value="AFM11_08795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5607"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043796">
        <property type="entry name" value="ESX-1_EspA/EspE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18879">
        <property type="entry name" value="EspA_EspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EspA_EspE" evidence="2">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="405" mass="43464" checksum="0D26349175DB2A49" modified="2016-06-08" version="1">MGALDGFYTTLSRARATFGEGVPATGEEFDGSARLREMEAAVKAAAPDDRWQGSAADAYAAKNEKHAATYGRLADLDKRMGAEVTNSAAVVAAGRHSLDSLSNWVSDMDTSIPRDQSGDRMRLILAAKGIGQINDVIQQSTDDMDAIARRIEDIRKQYDEIAGKEEGAQALDHPLGNPPPVDPLEEIKRKYQVDEDPDGALDWEPGWPWNHLTSPKHVTATEARILDSLAPWELQDLNQTKEAAEVESKVSFPPQNGANDTADNHTDAFRHAYWNALMTQRFGEQWTRDFAEAHERLPGNPATAEAMDLYNNEVGRNIAMANPDATPAELADLVEQAVNRGDTVVVAPNSDGEKLAWSNTVPEGEAGTTSKSTVPGQAPNPAGAGPGGVYDPGQPGGYGTSAGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR65</accession>
    <name>A0A132PR65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846924.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24420"/>
    <dbReference type="EnsemblBacteria" id="KWX24838">
        <property type="protein sequence ID" value="KWX24838"/>
        <property type="gene ID" value="AFM11_07810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5413"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="447" mass="46839" checksum="9FCA8274DF50170D" modified="2016-06-08" version="1">MTLLLWAPTVRADGAGSDTDIHVAQSLGGRELTVVIRRVGPVLGPLHVDVVTHQGDAPGPLQLTATSGGTATSSGQIELGPRPGIYSTTLNVDRAGPWELLVDDGTTVARIPFLVPVQVIPPWKKASDYGFFAAGALLIVSLGVALRSRRSWVALIPATGMVVALTVAVTGAVLSAYSPPPPQPGQDLDPTLDNMRDPYARIASNSLTPVDYSRPPVNLAVTMHGQTMQLGLIDSSTGRPVDDLLIHHGALIHLIVVSPSGAMSHLHPVRVAPGRYEVQFHPAESGTYAIAAEIARRGGGVQLVRASVTGRSPDAPSRVETISAGEITTTIAKAGTPSTVRARFGDTTDLQPWLGMTGHMMVIGPLPAGAATDIGDHALVAPVWSHAHAMVPPAPGAAGGQPDESVARYGPEVEFTYTFALPGRYKVWVQAERDYAILTAPTEVEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR89</accession>
    <name>A0A132PR89_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846957.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00345"/>
    <dbReference type="EnsemblBacteria" id="KWX24846">
        <property type="protein sequence ID" value="KWX24846"/>
        <property type="gene ID" value="AFM11_08490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5546"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="169" mass="18269" checksum="35C0841CDDE75F46" modified="2016-06-08" version="1">MKTKTALVEDITELLAKVGDKFDGDEDGDAERDFMAQRCPAELSAAVRTLPTLSMHLLAAIADGPVSIVGLAARSGQLKGTVSKHVQRLVEAGLVTRTPIPGNRKEIELALSADGELVAELHRQLHEEMNRGFADFLMRYSTAELQVLTKVLRDLAAAQKVGVRLVPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRS7</accession>
    <name>A0A132PRS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845151.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24974">
        <property type="protein sequence ID" value="KWX24974"/>
        <property type="gene ID" value="AFM11_05930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4377"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453532" evidence="2">
        <location>
            <begin position="31"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="151" mass="14731" checksum="6D77877231E5B6B7" modified="2016-06-08" version="1">MNIKRLTCASALIVALGAAPLALGAGVSAAQPGRPSCDFGNCQGPGGPGGPGPGGPGGPDRPGGPGGPGGFGPGGPGGPGPGGPGGPGGPGGPGGHWDAPPPPPPNLAWRGIDQGRFDHQPFNYNGHWVTPIFNPGFNNWGFWLFGIWIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRT0</accession>
    <name>A0A132PRT0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844998.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12860"/>
    <dbReference type="EnsemblBacteria" id="KWX24897">
        <property type="protein sequence ID" value="KWX24897"/>
        <property type="gene ID" value="AFM11_05485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4286"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="40"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="341" mass="37798" checksum="1671EDE6F2F37121" modified="2016-06-08" version="1">MSLIALEEHFAWDPASAGNVVGTWLRSNNPVAYERLYDRSTLRLEQMDAAGIDFQILSLFDPGVQDETDVARAIDLARRANDDLAETVRENPHRFGGFATLATQDPAAAAAELERAVTDLGLVGALINGHCRGRYLDDPAYEALFARAQELGAPIYLHPTTPHPAVMDAWFAPYVDDGLHLASWGFAAETGTHVLRLIYSGLFDKFPGLQMIIGHLGEMLPFAAYRVDRYYGLGGDGGSKQRLRRLPSEYLRSNFYVTTSGNFCPTAFRCTLDVMGTDRVMFSVDYPMDDNVDGVRFLADYPMDDASRRKISSENAIRLFGGRLPANLAPRARTPGRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS97</accession>
    <name>A0A132PS97_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Urea ABC transporter permease subunit UrtB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_05515</name>
        <name evidence="8" type="ORF">AWC31_12890</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845008.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12890"/>
    <dbReference type="EnsemblBacteria" id="KWX24902">
        <property type="protein sequence ID" value="KWX24902"/>
        <property type="gene ID" value="AFM11_05515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18850">
        <property type="protein sequence ID" value="ORX18850"/>
        <property type="gene ID" value="AWC31_12890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4293"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017779">
        <property type="entry name" value="ABC_UrtB_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03409">
        <property type="entry name" value="urea_trans_UrtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX18850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="294" mass="30634" checksum="0120926517A89E57" modified="2016-06-08" version="1">MDILIGQLATGLSLGSILLLAALGLSLTFGQMGVINMAHGEFIMAGCYTAYVVQQIISNAGASLLISLLVGFVVGGAMGALLEVTLIQRMYDRPLDTLLVTFGVGLILQQIARDIFGAPAVNVVAPSWLSGGVEILGAVVPKTRIFILILAIVCVAVLATVLKTSPMGRRIRAVVQNRDLAETSGISSRKTDITTFFIGSGLAAVAGVALTLIGSTSPTIGQSFLIDAFLVVVVGGLGQIKGTVIAALALGFLNSFIEYSTTASLAKVIVFVIIVIFLQVRPQGLFTVRTRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSA7</accession>
    <name>A0A132PSA7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05575</name>
        <name evidence="4" type="ORF">AWC31_12950</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845028.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12950"/>
    <dbReference type="EnsemblBacteria" id="KWX24912">
        <property type="protein sequence ID" value="KWX24912"/>
        <property type="gene ID" value="AFM11_05575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18860">
        <property type="protein sequence ID" value="ORX18860"/>
        <property type="gene ID" value="AWC31_12950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4305"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="103"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="409" mass="46379" checksum="111F8E95F589A626" modified="2016-06-08" version="1">MPSRILDYPVFDADNHFYEPKEALTQFLPDNRKGVIDYIDVRGRTKIVVRNHISDYIPNPTFEVVARPGAQEEYFRHGSGGKSFREVMGKPMKAIPAFRNPQARLEVLDGLGLDYTIMFPTLASLVEERLKDDPDLILDIIHALNQWMYETWQFNYENRIFSTPVINLGVVDRALAELEWCLERGAKTVLVRPAPVPGYRGTRSLGLPEFDPFWDACVKAGIPVCMHASDSGYAQYLNDWEPADEFLPFRPTAFRMVAMGKRPIEDTMAALVCHGALTRNPDLRILSIENGASWVPYLFYQFKDVYSKMPQEFPEDPIQAFKRGVYVAPFWEDDFKKMAELCGIDRIIFGSDWPHPEGLADPINLVGDLEAQGLDDAGIRKVMGGNLVDLFKVPSKKVYKPDVPALVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSI6</accession>
    <name>A0A132PSI6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843909.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21830"/>
    <dbReference type="EnsemblBacteria" id="KWX25318">
        <property type="protein sequence ID" value="KWX25318"/>
        <property type="gene ID" value="AFM11_03255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2526"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="306" mass="32574" checksum="C176B57395FD95F9" modified="2016-06-08" version="1">MSRALVIGEALIDIVERDGRISGEHVGGSPLNVAVGLSRLGRDVDFLTHIAQDDRGKRIVDYLKASGVQLVSGSLSAKRTPTALAVLDTTGQARYTFDIDWQLAGTPEVAPPLVAHTGSIATVLEPGCRATAALLDAYHLSATITFDPNVRPALITDDEAARGRIDRLIERADVVKASDEDLRWLDPRRDPEQVAKTWLSMGPSIVAVTMGDRGAFAMCAAGVVRIPARPVQVVDTVGAGDAFMTGLIDALWSRGLLGADRRRELARISTDALEQVLSTAVLASALTVARPGADLPDRVTLEATRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSM9</accession>
    <name>A0A132PSM9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_06270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845253.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29405"/>
    <dbReference type="EnsemblBacteria" id="KWX25032">
        <property type="protein sequence ID" value="KWX25032"/>
        <property type="gene ID" value="AFM11_06270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4448"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="99"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="312" mass="34296" checksum="187D514EE9B70447" modified="2016-06-08" version="1">MKLARPDLFHPRIVFAGCAALPDGDGDDGGLVAALRERGLHARWLAWDDPATSEADLVILRATWDYTDRLDEFLSWTRSVRNLLNAPEFVDWNTDKRYLEDLRRLGVPVVPTQYFNVDEPVRVPAGEVVVKPAVGAGSAGAQRFVDSVAAAAHATALQAQGKGVLVQPYDPRIADGETALVFLNGEESHAFTKGPILPPAGHTPEFDESGTYVEESLSPADPEDEVWRVGRLAIWAVTRLFDIEPEDLLYARVDVIGGPEDPRLLELELVEPSLGFRQLKQSDRADAEREFAIGVESALERFGLGPLSHRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSV9</accession>
    <name>A0A132PSV9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin 6A synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_03495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844048.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21655"/>
    <dbReference type="EnsemblBacteria" id="KWX25354">
        <property type="protein sequence ID" value="KWX25354"/>
        <property type="gene ID" value="AFM11_03495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2573"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043819">
        <property type="term" value="F:precorrin-6A synthase (deacetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11643">
        <property type="entry name" value="Precorrin-6A-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012797">
        <property type="entry name" value="CobF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036525">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02434">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="246" mass="27518" checksum="C94EA68F570BC281" modified="2016-06-08" version="1">MRRIHVIGIGAGDPDYVTAQAVSALNDTQVFFAMDKGQSKDELVALRRLICERFIREPGYRFVELPDPKRAEEGEYRQIVADWHAERARIWAHAIETELGPDRTGAFLAWGDPSLYDSTLRILEKVAEHVDFEYDVIPGVTAIQALTARHRIPLNDVGEPVLITTGRRLREQGLSGSAVVMLDADCSFRTCAPQTRIWWGAYLGTPDELLIAGTVGEVGDEIATVRAEARTRHGWIMDTYLLRSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSX4</accession>
    <name>A0A132PSX4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine transporter RhtB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_06850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845470.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25132">
        <property type="protein sequence ID" value="KWX25132"/>
        <property type="gene ID" value="AFM11_06850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4569"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="211" mass="22557" checksum="AA9AACBCBC1CF129" modified="2016-06-08" version="1">MAWQVWLAFFGAAIVISVSPGAGAIQSMATGLTHGVRRGYWSILGLEIGLMLQLTLVAVGLGAAVAGSLLAFNIIKWVGVAYLVYLAVRQWRTATLDLREQVGKSTDGGRLALVVRGFLVNATNPKGLVFFLAVLPQFVVPTAPLLSQYLAIGVTMIVVDLVVMGLYTGLAVRLLQWLHTPRQQTVLNRVFSGLFATAAVVLSLVRRSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSY1</accession>
    <name>A0A132PSY1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">glmU</name>
        <name evidence="18" type="ORF">AFM11_04150</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844392.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21005"/>
    <dbReference type="EnsemblBacteria" id="KWX25456">
        <property type="protein sequence ID" value="KWX25456"/>
        <property type="gene ID" value="AFM11_04150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2708"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="17">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="257"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="391"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KWX25456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="476" mass="48865" checksum="EEE2F5DC0C5955F8" modified="2016-06-08" version="1">MVSTTETAVIVLAAGAGTRMRSAIPKVLHAVGGRSMLAHTLHAVTALTPSHIVVVVGHGREQVSAEVARVSSVATAVVQDEQLGTGHAVSVGLAGLPSDFGGTVIVTTADVPLLDGATLAGLAAAHQGAGVTILTTTLADPTGYGRIIRDADRAVTAIVEHADADEAQRAVAEINSGVYAFDAAALRSALTQLRTDNAQGELYLTDAIALIRNQGLPVQAEHVDDSALVAGVNDRVQLADLGAELNRRIVAGHQRAGVTIIDPASTWIDVDVTIGRDTVVRPGTQLLGTTEIGSGCEIGPDTTLTDVEVGDRASVIRTHAQLAVIGEAATVGPFTYLRPGTTLGADGKLGAFVETKNAKIGTGTKVPHLTYVGDADIGDHSNIGASSVFVNYDGESKHRTTVGSHVRTGSDTMFIAPVNVGDGAYTGAGTVLREDVPPGALAVSDNAQRTIEGWVERKRPGSAAAEAARKARGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSY6</accession>
    <name>A0A132PSY6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Deferrochelatase</fullName>
            <ecNumber evidence="6">1.11.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxidase EfeB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_04185</name>
        <name evidence="9" type="ORF">AWC31_20970</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22585"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="6">Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844408.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20970"/>
    <dbReference type="EnsemblBacteria" id="KWX25461">
        <property type="protein sequence ID" value="KWX25461"/>
        <property type="gene ID" value="AFM11_04185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16512">
        <property type="protein sequence ID" value="ORX16512"/>
        <property type="gene ID" value="AWC31_20970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2714"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006313">
        <property type="entry name" value="EfeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01412">
        <property type="entry name" value="tat_substr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX16512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="442" mass="47620" checksum="8C62F9B860B5897F" modified="2016-06-08" version="1">MSSPHSESVDESVDKREPQPSGISRRKLFGAAGVTAAVVGAASAGALAGRASAAASSPHGQLQGPVPFRGERQAGIITEAQDRMHFCAFDVTTDKREDVIALLQQWTEMAERMTRGEETEPGGAVDGNPYAPPSDTGEALGLPASQLTLTIGFGPTFFLKDGKDRFGIADQKPAELAALPKFPNETMDPAKSGGDICVQACANDPQVAVHAIRNLARVGFGTVAVRYSQLGFGRTSSTTRDQATPRNLFGFKDGTNNIKADQTDLLDKHVWVADGDGPAWLTGGTYLMTRRIRMRIENWDRTTLLEQERVIGRQKGSGAPNGLQEEFEELDLDLADDKGTPLIDVDAHVRLVSPQNLGGIEILRRGYNFTDGTDGFGHLDAGLFFIAFVRSPEKQFIPMLGEMSRKDAMNEYITHTGTAVFACPPGLKEGDTSAYWGSTLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT51</accession>
    <name>A0A132PT51_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844548.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25518">
        <property type="protein sequence ID" value="KWX25518"/>
        <property type="gene ID" value="AFM11_04565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2792"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="45"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="226" mass="24834" checksum="24B20BF3BC737D71" modified="2016-06-08" version="1">MNPFSDPKTVATYADRPPRLVPGYAAMQQMATVLLAEHVPDDGRVLVLGAGGGLELRTFAQARAGWAFDGVDPAREMLRLAEDTLGPLLPRVRLHEGYIDDAPTGPFDGATSLLTLQFLDPAERRRTAEQVRRRLRPGAPFVVAHFSFPYSTDDERELWLSRYSAFATESGIDAAAMASARTAIETKLHILTPDEDEQVLRDAGFTDVSQFYAAFTFRGWVGYAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT72</accession>
    <name>A0A132PT72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844590.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25539">
        <property type="protein sequence ID" value="KWX25539"/>
        <property type="gene ID" value="AFM11_04670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2813"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="200" mass="21945" checksum="C08AFC513A0A445C" modified="2016-06-08" version="1">MSAPVLQIDRIDSSDERFGRAKRWEYQVFGQGNGYAGADDDAAGEMCHFRRWEQSSEFFVGLGGDEQPVGIARALRATPDLGIDSFSTAYVAGQANLIYRDWQAFFATVSPNRVAELATHAVVASHRKTGVSEQLWRHLAQTLSSDGVRYVTVALAAPLFDRYRSRFGDAIEQFADILPGYVGVDSVPAVIDLELLKPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTP2</accession>
    <name>A0A132PTP2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844936.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20370"/>
    <dbReference type="EnsemblBacteria" id="KWX25711">
        <property type="protein sequence ID" value="KWX25711"/>
        <property type="gene ID" value="AFM11_04775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2836"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="119"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="36982" checksum="A834D5B58097C54F" modified="2016-06-08" version="1">MTAPSKVSRSHHAGISPARAYRGRKYPVSDSAPVEVVEDGTSIGGRLASLAAMLTIRPTLAIGSHVPHLPWPFGVVNFAARLLRPVPGTIKATISLPNCTAQLVRAAGVLPADGKRSVILYLHGGAFLVCGANTHSGIVTSLSEYADSPVLVVDYRMVPKHSVGTALDDCYDAYRWLRLTGYEPDQIVIAGDSAGGYLGLALAERLLDEGESPAALVAMSPLFEIDNRTRANHPNIRRDAMFPAKAFDALVELVAAAATRKGEEIYEPLDHIEPGLPRTLIHVSGSEVLISDARKAAHQLAAAGVAVEVRVWPGQMHVFQIAGPMVPEAKRSLRQIGEYIREATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUB8</accession>
    <name>A0A132PUB8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <ecNumber evidence="5">4.1.1.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Regulator of ribonuclease activity homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RraA-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_01035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + oxaloacetate = CO2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842554.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34065"/>
    <dbReference type="EnsemblBacteria" id="KWX25905">
        <property type="protein sequence ID" value="KWX25905"/>
        <property type="gene ID" value="AFM11_01035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.212"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX25905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="224" mass="23040" checksum="06EDE5C9CC411A09" modified="2016-06-08" version="1">MTPITFNSAPPRLDPSLVGKLERVSFPTLGHYLEEGFVDPSLVRQAGSGRVVGRAVTVRTTATDSTMLHHAAGYLEPGDVLVIDTGGDRRHAPVGLVIAATAAARGARGIVVDGVVTDVDEIAELGIPVYAYGRSMLTTKLHGIDAGGHHVAVSIGGVAVSSGDVVLADVNGVFIGAAAVLAQVIDVALQDDAEEPALIDRIRAGARLGEETGATKALLGLRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUN2</accession>
    <name>A0A132PUN2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02055</name>
        <name evidence="3" type="ORF">AWC31_34835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843049.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34835"/>
    <dbReference type="EnsemblBacteria" id="KWX26051">
        <property type="protein sequence ID" value="KWX26051"/>
        <property type="gene ID" value="AFM11_02055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11829">
        <property type="protein sequence ID" value="ORX11829"/>
        <property type="gene ID" value="AWC31_34835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.421"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_3" evidence="1">
        <location>
            <begin position="43"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="119" mass="12918" checksum="3565D3633C10D930" modified="2016-06-08" version="1">MPELIPAGPDAVAAMTPSSYVTAETLREGDPAETEAVHLASSDEKFTVGSWRAEPYAEFIESYPGDEYTRVLEGSITLTGDDGVAHTFGPGDSFTLTKGWRGEYRVTEPLVKQFAIYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUV2</accession>
    <name>A0A132PUV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843190.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35080"/>
    <dbReference type="EnsemblBacteria" id="KWX26093">
        <property type="protein sequence ID" value="KWX26093"/>
        <property type="gene ID" value="AFM11_02300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.471"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="171" mass="18425" checksum="E0D57AC30EC28BDB" modified="2016-06-08" version="1">MCNAAIRPTSPDDLDTIAAIYAHHVESGVATFELTPPDRAEWDRRLTTAHDLGLPFLTASLDGSVVGYAYCAPWKTRPAYRHTVENSIYLVPHAAGRGIGAQLMTALLDGCAAAGIREVIAVVVDTEDAAASLALHRRHGFVEAGRLRAVGFKHGRWLDTVLLQRSLPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVC5</accession>
    <name>A0A132PVC5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyrimidine-nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_02015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34795"/>
    <dbReference type="EnsemblBacteria" id="KWX26273">
        <property type="protein sequence ID" value="KWX26273"/>
        <property type="gene ID" value="AFM11_02015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.412"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="324"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX26273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="413" mass="43112" checksum="6EB84D4AC54699D3" modified="2016-06-08" version="1">MLSDAAIDWVIDAYTNGRVAEEQMSALLMAIFLRGMTPAEIVRWTAAMITSGERFDFTDLRRDGRPLALVDKHSTGGVGDKITIPLLPVVMACGGAVPQASGRGLGHTGGTLDKLESIPGFSAELSKDRIRQQLRDVGAAIFAAGELAPADRKIYALRDITSTVDSLPLIASSIMSKKLAEGARALVLDVKVGRGAFLKTEPESRELARTMVELGNANGVPTRALLTDMNRPLGRAVGNAVEVAESLEVLSGGGPDDVVALTLALATEMVDAAGIDGVDPADTLRDGSAMDRFRALVAAQGGDLSQPLPVGSARETVTAPRDGVMGDIDAMGVAMAAWRLGAGRAQPGEPVQFGAGVRIHRRPGEPVSAGETLFSLYTDTPDRFSAALAELDGAWAVGESAPADPPLLIDRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVG4</accession>
    <name>A0A132PVG4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02685</name>
        <name evidence="2" type="ORF">AWC31_35460</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843389.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35460"/>
    <dbReference type="EnsemblBacteria" id="KWX26157">
        <property type="protein sequence ID" value="KWX26157"/>
        <property type="gene ID" value="AFM11_02685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11935">
        <property type="protein sequence ID" value="ORX11935"/>
        <property type="gene ID" value="AWC31_35460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.551"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="144" mass="15502" checksum="37FED78352BDFD5A" modified="2016-06-08" version="1">MAQGPGQHQPRARGERAMEVRVAARLENLAVLRTVVAAVATFEDLDFDVVADLRLAVDEACTALIRSALPESTLALLIDPRQDEVVISASTTCMGSEVVEPGSFSWHVLSSLTDEVHTFTDGDGPDKGRVFGIALTTRRASLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVM8</accession>
    <name>A0A132PVM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamyl cyclotransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Gamma-glutamylcyclotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02230</name>
        <name evidence="3" type="ORF">AWC31_35010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843146.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35010"/>
    <dbReference type="EnsemblBacteria" id="KWX26082">
        <property type="protein sequence ID" value="KWX26082"/>
        <property type="gene ID" value="AFM11_02230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11859">
        <property type="protein sequence ID" value="ORX11859"/>
        <property type="gene ID" value="AWC31_35010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.456"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="PTHR12935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="155" mass="17152" checksum="394C55C6A43BA052" modified="2016-06-08" version="1">MPLYAAYGSNMHPEQMLQRAPHSPMAGTGWLHGWRLTFGGEDIGWEGALATVVEDPLSKVFVVLYDMTPADEQSLDRWEGSELGFHKKIRCRVDRLSSDTTTDPVLAWLYVVDAWEGGLPSARYIGVMADAAEIAGAPPEYVHDLRTRPARNIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB15</accession>
    <name>A0A132PB15_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000043">
        <property type="protein sequence ID" value="KWX19523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040723.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19523">
        <property type="protein sequence ID" value="KWX19523"/>
        <property type="gene ID" value="AFM11_35315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5794"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="28"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="31760" checksum="04F95DB0E2946F75" modified="2016-06-08" version="1">MINETSTAPRPGATSRLPLLNGHSMPRIGLGTWPMLDAECEQAVRCAVQTGYRLVDTAVQYRNEEAVGRGIRTAGVPRAELFISSKFNKESHSVDGVRRAYDESLRKLRVDYLDMFMCHWPVPALGAYAEAWKGLVTLLEEGAVKAIGVSNFKPAHLRKIIEATGVVPDVNQIQLSPALARTQPRAVHRELGILTQSWSPIGRESGLRANPLVVAIADRLNRSPAQVLLRWHIQQDLVPIPQASDPVWLRENISAFDFTLTADDMNDLARLDMGETAARDSDAAENGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBB8</accession>
    <name>A0A132PBB8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_35030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859622.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19610">
        <property type="protein sequence ID" value="KWX19610"/>
        <property type="gene ID" value="AFM11_35030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5735"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="518" mass="55282" checksum="EAB88F7C449C3E5E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBG5</accession>
    <name>A0A132PBG5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859318.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19658">
        <property type="protein sequence ID" value="KWX19658"/>
        <property type="gene ID" value="AFM11_34545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5254"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="369" mass="42331" checksum="78F13AB4C024496E" modified="2016-06-08" version="1">MAVDDVGRAYLVDAVRPLHPEEQTVAEMLQGWRNQQLSRNLQFETIDSRIKQVQRFIEHSNEFPWTWTVAMVDEFFGDLRSIHGLAQSSIRSYQVGLRQFCSYVSNPDYGWDRVCEALFGTHPSQVFFDWNTARHVQENEARPEKRAFTKRELQDFFDHADEQVSAVVASGRKGWLPAYRDAVMFKIAYSYGLRFNELAHLQTVDFARNPHAKEFGKLGLVHVRYGKAKKGSPPKRRSVLTVFDWTPEVLVDWLENGQPHMDDGIDLFPSERGNLVSETTLIRRFRRYCDDLDLSPGLDLHSFRRSYATHLLEAGWDAMFVQHQMGHEHASTTAIYSCVSSDYRTRTLRNALDATIAAALEPKLNGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBW7</accession>
    <name>A0A132PBW7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxylate--amine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33730</name>
        <name evidence="2" type="ORF">AWC31_08025</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858854.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08025"/>
    <dbReference type="EnsemblBacteria" id="KWX19819">
        <property type="protein sequence ID" value="KWX19819"/>
        <property type="gene ID" value="AFM11_33730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10116">
        <property type="protein sequence ID" value="ORX10116"/>
        <property type="gene ID" value="AWC31_08025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5083"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="292" mass="32015" checksum="58BC3BE7405712B5" modified="2016-06-08" version="1">MTSSYPNAGRPADLPELEDAIVVAAFEGWNDAGDAASDALDHLDAIWEAEPIVEIDDESYYDYQVNRPVIRQVDGVTRELVWPSMRISHCRPPGSNRDVVLMHGVEPNMRWRTFCAELLAIADKLNVQTVVILGALLADTPHTRPVPVSGAAYSSDSAKFFGLEETRYEGPTGIAGVFQDACVQAGIPAVTFWAAVPHYVSQPPNPKATVALLRRVEDVLDVEVPLADLPAAAEEWEAAVTEMTADDEEIAEYVASLEQRGDAEVDMHEVLGKIDGDALAAEFERYLRRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC99</accession>
    <name>A0A132PC99_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_33265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858588.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16960"/>
    <dbReference type="EnsemblBacteria" id="KWX19961">
        <property type="protein sequence ID" value="KWX19961"/>
        <property type="gene ID" value="AFM11_33265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4985"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX19961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="380" mass="42040" checksum="D312D19C82032D02" modified="2016-06-08" version="1">MDLSFDDETEAFRAEVREFLEANRESFPTKSYDTLEGFEQHRRWDKVLFDAGLSVIAWPKKYGGRDATLLQWVVFEEEYFRAGAPGRASANGTSMLAPTLFAHGTEEQLDRVLPKMASGEEIWAQAWSEPESGSDLASLRSTATKVDGGWKLNGQKIWSSRAPFGERGFGLFRSDPEAQRHKGLTYFMFDLKAEGITVRPIAQLGGDTGFGEIFLDDVFVPDNDVIGGVHDGWRAAMSTSSNERGMSLRSPARFLAPAERLVSLWKDNPDPVFTDRVADAWIKAQAYRLHTFGTVTRLANGGELGAESSVTKVFWSDLDVALHQTALDMRGADGELMDSWTEGLLFALGGPIYAGTNEIQRNIIAERLLGLPRESGGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCD8</accession>
    <name>A0A132PCD8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858301.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19990">
        <property type="protein sequence ID" value="KWX19990"/>
        <property type="gene ID" value="AFM11_32790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4887"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="112" mass="11794" checksum="984689251E756B3E" modified="2016-06-08" version="1">MPYPTAGFTAVVCSRCSSAESVLDELRAAVRRAPHGMLISSGCLLDQIRCVGRTDGVMVLVQPCAIDRTPTGPALMFGPIDDAGSAAQLRDWLDQGHWAAPLPVAVMNGKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCD9</accession>
    <name>A0A132PCD9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19897">
        <property type="protein sequence ID" value="KWX19897"/>
        <property type="gene ID" value="AFM11_33500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5033"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="403" mass="40056" checksum="6E9CE581DC127564" modified="2016-06-08" version="1">MLAVGVMIGTPAIAFAEPSIDGGVTSNGETASGSPEPTSSTTGSDTTTASLEPTAADSAEDSAAAAERNAVEGVESTVGSGRNPGDPVTTEEGGSTETSATEQPSATTSATDEESVTADADAGSANSDSDSNTATSESNESEGSGAAPAAQTQSAGSTAAPPDDTPSLPATETVPAAAYAMAVPYLALLGVQAVAAPVAHVLAAVTYLLAEVVVVPLLHLQRDLAMLFSIAGVEPVVDSLARIGVVLSPSVQDALASKFGEPVPGASPLDAASIAASAPEAVFPAAETPPPAVAPHEPGESVLSRVSSFIGDITRKLLESPTLMALAIAALPGLAGLLVLTAGGVRLGYRQAKARVAIQMHGIARFVAMEPTVSARCGALVLLRPRTWSAREPDVTAMLDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCF7</accession>
    <name>A0A132PCF7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858355.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32355"/>
    <dbReference type="EnsemblBacteria" id="KWX20009">
        <property type="protein sequence ID" value="KWX20009"/>
        <property type="gene ID" value="AFM11_32910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4911"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="228" mass="24071" checksum="871A543E5769A363" modified="2016-06-08" version="1">MRAHELVLERIERDLVAGTLAVGDRLPAERALAESLSVSRASVREAIRVLEAMGVVRTAAGSGPDAGAIITADAATSIGSALRLHTATRALPIEDLVRTRILLETSALRDAAALSPRPDLTEIRAMLDAMDDPALEPEQFHRLDADFHLALTALAGNVVVEAMMAALRGPIQGYILAGVPLLDDWAGVASNLRCEHRGIVTALSRGQGNKAAELARAHIQGYVDLIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCI3</accession>
    <name>A0A132PCI3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858450.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20038">
        <property type="protein sequence ID" value="KWX20038"/>
        <property type="gene ID" value="AFM11_32915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4912"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="129" mass="13543" checksum="EF53B9DC2AE26DF9" modified="2016-06-08" version="1">MAGLTAACTDGANTAAASPEHAVHRHIAAAKTGDVATLRSGACGALATAMEPRTDDEVRAHFLEAYSAGPDLLSVEPDGAGNRRIVTGYYSDVTDLDIAFTVENLDGWKVCEIRRGNGRFGPLPGPFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCU9</accession>
    <name>A0A132PCU9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_32605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858234.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19740"/>
    <dbReference type="EnsemblBacteria" id="KWX20124">
        <property type="protein sequence ID" value="KWX20124"/>
        <property type="gene ID" value="AFM11_32605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4849"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453014" evidence="6">
        <location>
            <begin position="21"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="480" mass="51228" checksum="7C2681DE39A14219" modified="2016-06-08" version="1">MSRRHLFGAVIATCVVLPLAACSTLVEGTAVSVFDDPFSVAGMPATDGPSGLRPDASEPSRDATDTDGGKIDNLAVSAVSDVEEFWSTAYSETFEGEFEPVEELISWDAESFDGEFCGLETYGLVNAAFCKPDRTIGWDRGVLLPALRQLNGDMGVVMVLAHEYGHAIQQQAKLVRRNTPTLVAEQQADCLAGTYMRWVAEGNSPRFTLSTGDGLNNLLASVIGFRDPLLSEADVEVGVDEHGSAFERISAFQFGFTDGASACATIDVKEINQRRGDLPVLLPEDQTGELPITEQSVRSMIDALNVLFKPRVRPELSFDTAAAEDCPSARPSPPVSYCPDTNTIVVDLDELEVLGLRPEEQEAGGLAAGDNTAYSVLISRYMLALQHERGLVLNNAEAALRTACLAGVATAKITQPVTTPDGNTIVLTAGDLDEAVSGILTNGMVASDVNGESVPSGFSRIDAFRVGILGDEERCLKRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCW7</accession>
    <name>A0A132PCW7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858833.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08070"/>
    <dbReference type="EnsemblBacteria" id="KWX19812">
        <property type="protein sequence ID" value="KWX19812"/>
        <property type="gene ID" value="AFM11_33685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5073"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="215" mass="22262" checksum="2AF0CD54DCC48DF4" modified="2016-06-08" version="1">MYHNGIDIAAPTVAVAYHSGFGHTATLAQAVAAGAHEGGAAVNVIAVDTMTEADWDVLDNVDAMIFGSATYMGNVSAGFQAFAEQTGRRCLNGTWRDKIAAGFTNSGAKAGDKLNTLSSLAIFAAQHHMHWVNLGLGAGWNSSAGSENDLNRLGFWLGAAASTDVDANPDQVHPSDVQTCRHLGRRVAEVTRQLNIGRTVSSAASGPAASSAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCX7</accession>
    <name>A0A132PCX7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidylinositol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858862.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08000"/>
    <dbReference type="EnsemblBacteria" id="KWX19822">
        <property type="protein sequence ID" value="KWX19822"/>
        <property type="gene ID" value="AFM11_33755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5088"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022292">
        <property type="entry name" value="CHP03843"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03843">
        <property type="entry name" value="TIGR03843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="29953" checksum="4A7D1CA1877762EE" modified="2016-06-08" version="1">MTSTADGGPGQSRSDGEVLDNGELTVIGRIRSASNATFLCEAHLRDREVHCVYKPVAGEAPLWDFPDGTLAGRELGAYLVSAALGWNIVPYTIIRDGPAGPGMLQLWVDQPGDEVGDEPESGPDLVDLLPAGRIPPGFLPILQAYDYAGDEVTLVHADDPRLFRLAVFDVLINNADRKGGHILSGVDGQVYGVDHGVSLHTEDKLRTVLWGWAGKPVDDDTLADIAALRDGFGAGLGEQLCGLVTEREVAALHARILALLDNPVMPMPDRRRPIPWPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDA5</accession>
    <name>A0A132PDA5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_31715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857645.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26335"/>
    <dbReference type="EnsemblBacteria" id="KWX20296">
        <property type="protein sequence ID" value="KWX20296"/>
        <property type="gene ID" value="AFM11_31715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4247"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="253" mass="26544" checksum="4ED650E1EFF460F2" modified="2016-06-08" version="1">MSDVVLRERRGRTLIITINRPEARNAFNLAVAQGLADAMDELDATPELSVGIITGAGGNFCAGMDLKAFASGEVPHVPGRGIGFTEQPPRKPLIAAVEGYALAGGTEIVLATDLVVASKVAKFGIPEVKRGLVAAGGGLLRLPHRIPYQKALELALTGDNFTAEEAAAWGFVNKLTEPGAALTGAIELAERITANGPLAVAVTKEIIVKSAGWSEDEMWKKQGELIMPVFSSKDAIEGATAFAEKRAPNWTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDG2</accession>
    <name>A0A132PDG2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urea carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857554.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26110"/>
    <dbReference type="EnsemblBacteria" id="KWX20267">
        <property type="protein sequence ID" value="KWX20267"/>
        <property type="gene ID" value="AFM11_31530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4211"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017791">
        <property type="entry name" value="Urea_carboxylase-assoc_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03424">
        <property type="entry name" value="urea_degr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="202" mass="21525" checksum="E8D6C5DFB868267D" modified="2016-06-08" version="1">MTATIVDEIVAPRGPWSKIVKAGDVLTIIDLHGNQAVDTLFYGADDHGVRYSAPATVAAQGNIFLTTGSVLRDSDGEPMLTIIDDEVGNHDTLGGACSQESNTLRYGHHTKHQHACVENFIGEGARWGLTKADIVSNINFFMNVPVDPDGSLGIVDGLSAPGKKLSLRAEIDTLVLVSNCPQINNPCNGFDPTAVRMVVTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDP0</accession>
    <name>A0A132PDP0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856778.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20449">
        <property type="protein sequence ID" value="KWX20449"/>
        <property type="gene ID" value="AFM11_30155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3927"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="29"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="327" mass="35035" checksum="E60B59220671B15C" modified="2016-06-08" version="1">MTSSVVAWDESEPAQPAVDWRKLGSVYLFGNGKGGVGKTTCSTHAAALVASDGARVLLVDLNGQGNVANVLGFANSAANDKGVNLFSAITAGAALTPVRDVRPNLDVIPGGPMVRRITPVLAAEMGNPQSAKQVLMSLALALQKISHAYNLIIIDSPPESQLLLQLALCAARFVVVPMKTDNLSRTGLRELAGDLRAMREHNPHLILLGCFVFASGTNARAIRKETTENVSKDLGQKADDVMLKSFIRHSEAVGQQVPKYGRLAHELEQEIVNNPKPWELKRGTATGSAVVSTTTRPVAEDFANLTKEILTRGSQIRAEMMEKGVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE62</accession>
    <name>A0A132PE62_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856668.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25345"/>
    <dbReference type="EnsemblBacteria" id="KWX20629">
        <property type="protein sequence ID" value="KWX20629"/>
        <property type="gene ID" value="AFM11_30005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3893"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="400" mass="42701" checksum="6642517CAF8A9042" modified="2016-06-08" version="1">MSTGALDGVRVIELGTLISGPFAGRLLGDMGAEVIKIELPKTPDPLRTWGQAELDGHHFFWTVHARNKKAVTLDLRAPRGREIFLDLVERSDIIVENFRPGTLEKWDLGYDVLRERNKGIILVRVSGYGQTGPDAGKAGYASVAEAASGLRHMNGFPGGPPPRLALSLGDSLAGMFAAQGALAALYRRTVTGEGQIVDTALTESCLAIQESTIPDYDIGGVVRGPSGTRLEGIAPSNIYQSANGSWVVIAANQDTVFRRLCEAMGRPELATDERFANHLARGRNQDELDKIIGAWAAEREPGEIIATLSAAGVISGPINTVAEVVDDPQLQARGMIADHWDERVQRAVKGPGIVPVLSESPGSIRNAGPARPGQHNDEVYGGLLGRSADELESLRAEGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEA5</accession>
    <name>A0A132PEA5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF732 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856452.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24925"/>
    <dbReference type="EnsemblBacteria" id="KWX20557">
        <property type="protein sequence ID" value="KWX20557"/>
        <property type="gene ID" value="AFM11_29585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3808"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453182" description="DUF732 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="2">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="111" mass="12084" checksum="0B0DFAD0D4016A3D" modified="2016-06-08" version="1">MKRLAAAAIACAATALALSAPAYADPDTDFANELHTHGIYGPRDYNAWIGKLTCKRMYQGVDADAHESAKFVSDQLDKDSTTAQAWQFLGTAVNYYCPEKRVVLEQLAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEB0</accession>
    <name>A0A132PEB0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20665">
        <property type="protein sequence ID" value="KWX20665"/>
        <property type="gene ID" value="AFM11_28965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3673"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="111" mass="12646" checksum="1995948DB2641020" modified="2016-06-08" version="1">MRLCCPGVWAGRIDDDMATNKRRRHTPDQIIRKLAEGNKLLGTGQELAEVCRHLEITESTWHRWVAQYGGMKANDAKRLKELEAENARLKKLVANQALDIDMLKEISSGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEE4</accession>
    <name>A0A132PEE4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_29150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040134.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20691">
        <property type="protein sequence ID" value="KWX20691"/>
        <property type="gene ID" value="AFM11_29150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3714"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="110" mass="12080" checksum="DFEB1F0BFE296D20" modified="2016-06-08" version="1">MTYVITEACVDVLDKTCIKECPVDCIYEGERMMYIHPAECIDCGACEPVCPVEAIHYETDLPDGVRHYQQINADFFSEIGSPGGARRVGKLSADPPIVKNLELRSGTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEG9</accession>
    <name>A0A132PEG9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20739">
        <property type="protein sequence ID" value="KWX20739"/>
        <property type="gene ID" value="AFM11_28995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3680"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="40"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="404" mass="43024" checksum="291891C80598E720" modified="2016-06-08" version="1">MRARRTAVALAGLFLTLTAAFGYISLGTFGYNPVRATVGLRIQLSESGGLLASQDVTLRGVQIGKVLAVQVDGDGVVAEIEIDPDLQIPKDAAFRVSGLSPAGEQYLDIRPANGTGPFLRDGDTVSATQTDIPVQFHRLVTDAEGLLAQLDPAKLSAMTKEMGVGAAGPAKLSAIFDGGVFLISTLDSVLPETIRVIRNSRTIFTMVTDAESELLETATDVREIVAGANRMEGGYRQLVDTGSRPLTALDAVIADNSETMVQLLGNLTTVAQLSYVRVPALKALFPPLEQRGSVIDAVASTFRDGGVWEIVDPYPRYSCDYNLPRRPPSQADFPEPYRYTYCNNPDPAVLIRGARNAPRPPGDDTDRPPPGHDPLATTDPAPVGPNTIPTPYGGPPKNLAPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEH7</accession>
    <name>A0A132PEH7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040673.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20749">
        <property type="protein sequence ID" value="KWX20749"/>
        <property type="gene ID" value="AFM11_29280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3742"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_C" evidence="1">
        <location>
            <begin position="256"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="394" mass="41152" checksum="E4372F40680028C7" modified="2016-06-08" version="1">MSSRALAGRPAIAAVEELRPGRYPDEDGAGMPELVLRRFLEGAQVGPDDVDGLLVCPAGMAAGHGADIFVHERLNDALGIRPRFCETINAGGATYTIMLSRAALAIGAGLADSVLCVGAGKFPKVGAGGADAMARMISHPDFEYPYGSFIPALYALAATRHMAERGTSRDALAAVAVCSRDWALRHPDALMRDAGPLTIEMVLDSRPIAWPFNLLDCSVPCEGGAAFLVTSGERARELTEQPAYLLGFGEFHDHGNISHASDFATMGAGVSARAAFDMAGVSPSDVDLAELYDAFTINPILLVEETGLVEPGKGGHFFLDGRGAPGGDLPINTYGGLLSFGHTGDASGMSMLVEGARQVMGQAEGRQVDAEIALVHTYGGVMADHSTVLLGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEL3</accession>
    <name>A0A132PEL3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856102.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20770">
        <property type="protein sequence ID" value="KWX20770"/>
        <property type="gene ID" value="AFM11_28400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3557"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="128" mass="14022" checksum="AEF765EAB8517BE6" modified="2016-06-08" version="1">MNTATVILIVMIAVVAIVLVGLLAWLARNNRNQNRHNEAGKIREDAQQETLQVKQREAWADETHARARAAQAEADVKAAQASGLQQQATARRGEAAASRSQVNEQLDRADTMDPATELPETPRSSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF62</accession>
    <name>A0A132PF62_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_27585</name>
        <name evidence="6" type="ORF">AWC31_10115</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX09042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855941.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10115"/>
    <dbReference type="EnsemblBacteria" id="KWX20970">
        <property type="protein sequence ID" value="KWX20970"/>
        <property type="gene ID" value="AFM11_27585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09042">
        <property type="protein sequence ID" value="ORX09042"/>
        <property type="gene ID" value="AWC31_10115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3391"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="209" mass="23712" checksum="502E5420AE9232A5" modified="2016-06-08" version="1">MKQMLQSSVPRPIDHAKREELLAAAGVVLARTGVIDTSLRTLAAEMGTSARMLVYYFGSKEQLILEVMVRQQRAAIPETDDLELPASIEAHRQWCFDDWHACTRGERRDNLRVVLQVFGAACGVDSPYREYTWDTLSLLTRNSQARLEALGMPTHVAETRSRIALAAFQGFIIEYFTADDPAHVDDTFARFVDEFLLAPFEPARRPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFG1</accession>
    <name>A0A132PFG1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040998.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20732">
        <property type="protein sequence ID" value="KWX20732"/>
        <property type="gene ID" value="AFM11_29445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3779"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="66" mass="7232" checksum="D9F9D323F99A0828" modified="2016-06-08" version="1">MTVLPTDRFTHEFVDFIPADLDAGVLYVSLPYATVMHLCACGCAGCVQQSGVRVGPDQRYRRVVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFL1</accession>
    <name>A0A132PFL1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="8" type="ORF">AFM11_27200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855339.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07130"/>
    <dbReference type="EnsemblBacteria" id="KWX21064">
        <property type="protein sequence ID" value="KWX21064"/>
        <property type="gene ID" value="AFM11_27200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3315"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="67"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="314" mass="35161" checksum="812AE4A94681B5F0" modified="2016-06-08" version="1">MTVVPEGRKLLRLEVRNAQTPIERKPPWIKTRAKMGPEYTELKGLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGEQCTRRCDFCQIDTGKPAELDRDEPRRVAESVQAMGLRYSTVTGVARDDLPDGGAWLYAETVRQIKQLNPNTGVELLIPDFTGNAAQLEDVFESRPEVLAHNLETVPRIFKRIRPGFRYDRSLAVLTAARNFGLVTKSNLILGMGETIDEVHTALRDLHDAGCDIVTITQYLRPSPRHHPVERWVHPDEFVALSAYAEGLGFAGVLAGPLVRSSYRAGKLYAQAARVRFADQPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFP2</accession>
    <name>A0A132PFP2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase / dehydrase and lipid transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27365</name>
        <name evidence="2" type="ORF">AWC31_07300</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855431.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07300"/>
    <dbReference type="EnsemblBacteria" id="KWX21094">
        <property type="protein sequence ID" value="KWX21094"/>
        <property type="gene ID" value="AFM11_27365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09992">
        <property type="protein sequence ID" value="ORX09992"/>
        <property type="gene ID" value="AWC31_07300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3347"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX09992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="129" mass="14385" checksum="695E8C604847668B" modified="2016-06-08" version="1">MNSIQIADETFVAADPVAVGEAVADPASWRRWWPDLGLAVVEDRAEKGQRWTVTGALTGTMEIWLEEMLDGVILHYFLHAEPSGATAWQLARMDLAKMNHRRRVAGKAMAFEIKQRLEASRPIGVSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFP7</accession>
    <name>A0A132PFP7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854776.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23435"/>
    <dbReference type="EnsemblBacteria" id="KWX21151">
        <property type="protein sequence ID" value="KWX21151"/>
        <property type="gene ID" value="AFM11_26165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3099"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="235" mass="24410" checksum="2740BAB70DC2385C" modified="2016-06-08" version="1">MTTKTALVTGGASGIGKAIAERLAADGHQVATLDLTATDAAHAYTADVTDRAQVDAVFKAVREELGPVTILVNAAGLSGFKPFADITFEEWQRVVNVNLNGVFHVVQAALPDMVAAGWGRIVNISSSSTHSGVPYMSHYVSAKSAVNGLTKSLALEYGPAGITVNAVPPGFIDTPMLRAAEARGELGNIQDTIDATPVRRMGKPEDIAATCSFLISDEAGYITGQIVGVNGGRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFZ3</accession>
    <name>A0A132PFZ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26755</name>
        <name evidence="3" type="ORF">AWC31_22580</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855165.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22580"/>
    <dbReference type="EnsemblBacteria" id="KWX21279">
        <property type="protein sequence ID" value="KWX21279"/>
        <property type="gene ID" value="AFM11_26755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15686">
        <property type="protein sequence ID" value="ORX15686"/>
        <property type="gene ID" value="AWC31_22580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3222"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453244" evidence="1">
        <location>
            <begin position="32"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="159" mass="16377" checksum="1C6FA475B51F60DD" modified="2016-06-08" version="1">MQHTVRSATPAIATALAVSAASLLTGCDAGSDIMAPLALPSSQIKDTQAQSGVLPSVAASPQQGRNGQLVVSSQQQAYLDALREAGVNPSSDLLALSIGSHVCQARAAKQNDQAVWDFVLPLVRSDVRTAHSGDGGVEVPGEVNAATSDYIRIATERLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG14</accession>
    <name>A0A132PG14_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854386.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24785"/>
    <dbReference type="EnsemblBacteria" id="KWX21288">
        <property type="protein sequence ID" value="KWX21288"/>
        <property type="gene ID" value="AFM11_25495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2961"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="35"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="585" mass="62216" checksum="291C85C642DE91FF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG18</accession>
    <name>A0A132PG18_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_28045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855817.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10565"/>
    <dbReference type="EnsemblBacteria" id="KWX20932">
        <property type="protein sequence ID" value="KWX20932"/>
        <property type="gene ID" value="AFM11_28045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3484"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004707">
        <property type="entry name" value="MmpL_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00833">
        <property type="entry name" value="actII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="801"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="833"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="876"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="63"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="614"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="965" mass="105978" checksum="AEFED07DDAD4814E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG59</accession>
    <name>A0A132PG59_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_25635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854451.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36260"/>
    <dbReference type="EnsemblBacteria" id="KWX21311">
        <property type="protein sequence ID" value="KWX21311"/>
        <property type="gene ID" value="AFM11_25635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2990"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="264" mass="27320" checksum="B4DDED2AE4510CAA" modified="2016-06-08" version="1">MTRPYSPYDTAPTERFGERPQGPGSYREHTSYPGSPGYVGSDYGAYAGDYENYDDFVDDDDIEFYEESIDRRWIWVAGVAGAILLVAVICTVVILGGGDSGSVSATVAAPPQTSQPATTAPQDATSKPVPPRAAPTGPLSPETVTTVTPSAPAPSATAAPAPAAPPAEAAPPPPDPRTITYTVTGNRQLIDLVTIVYTDAQGALQTDINVALPWTKTVVLNPGVQLKSVTATSVAGQLNCAITDAAGAVLVQQANNSMIATCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGB6</accession>
    <name>A0A132PGB6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTPase EngC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_25895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854569.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36000"/>
    <dbReference type="EnsemblBacteria" id="KWX21353">
        <property type="protein sequence ID" value="KWX21353"/>
        <property type="gene ID" value="AFM11_25895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3043"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="99"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="4">
        <location>
            <begin position="118"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="326" mass="34623" checksum="4A6CBC5E4105D6D4" modified="2016-06-08" version="1">MSAREYDESDVRIRPGRGTRPRTKTRPDHADARSAMVVTVDRGRWGCALARDPHHRVTAMRARELGRTPIVVGDDVDVVGDLSGRPDTLARIVRRGERRTVLRRTADDTDPTERVVVANADQLLIVVALADPPPRTGFVERALIAAYAGGLQPILCLTKSDLAPPEPFAAQFDGLDLTIVNAGRDDPLDAVAPLLTGQVTVFLGHSGVGKSTLVNRLVPEADRATGEVSGVGKGKHTSTQSIALPIDGDGWVIDTPGVRSFGLAHIEPDDVILAFSDLADTIDDCPRGCGHMGPPADPECALDTLSGAAADRVAAARRLLAALKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGL4</accession>
    <name>A0A132PGL4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="9">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltX</name>
        <name evidence="13" type="ORF">AFM11_24945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854082.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27200"/>
    <dbReference type="EnsemblBacteria" id="KWX21466">
        <property type="protein sequence ID" value="KWX21466"/>
        <property type="gene ID" value="AFM11_24945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2351"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="6"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="12">
        <location>
            <begin position="339"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX21466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="486" mass="53944" checksum="91E65631A22E13C6" modified="2016-06-08" version="1">MSNDTVRVRFCPSPTGTPHVGLVRTALFNWAYARHTGGTFVFRIEDTDAARDSDESYAAILDALRWLGLDWDEGPEVGGPYEPYRQSQRSEIYRDVIARLLEAGEVYEAYSTPEEVEARHHAAGRNPKLGYDNFDRTLTDEQRKVFADEGRKPVLRLRMPDEDLSWNDLVRGPTTFPAGSVPDFAITRASGDPLYTLVNPVDDAMMKITHVLRGEDIMPSTPRQIALYRALMRIGVAERVPEFAHLPSVLGEGNKKLSKRDPQSNLFLHRDRGFLPEGLLNYLALLGWGIADDHDVFSLDEMVAAFDVVNVNSNPARFDQKKADAINAEHIRLLTPEDFTARLREYFVTHGYDTGLDDAGFAEAAALVQTRIVVLGDAWGLLKFFNDHAYEIDEKSAAKELKPESAPVLDAALSALEPVGEWTTANIEAALKTALLDGLELKPRKAFGPIRVAVTGATVSPPLFESMELLGADRSLARLRAARGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHJ1</accession>
    <name>A0A132PHJ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853092.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21773">
        <property type="protein sequence ID" value="KWX21773"/>
        <property type="gene ID" value="AFM11_23230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1999"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="30975" checksum="09537466C3FDFFEB" modified="2016-06-08" version="1">MALSFRRARSVMSAEVAAIRSRDPDLDASDIAGFTLPILVRVAGVIAIGVVPLLVVRNGESENSQLVAIIGSFALVVICAAVVAWLTSIVISGLVVMILYRTRPTASSRLVTRILTDSFMRIDDSTSALALLALLAGLLSLAFGLPTRTADELANSVLDDLLAAQVGVLLVALALAFIAESVRSAADIVDDQSLMLAWPWALIIASLSWVLATIAGPFEATRMLTILLHEWLPAVVDGVPSTEVIAELVPPGARWLVAFGPVPIIAAIWAYQAAKHGGFAAIREFFEDDATAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHQ6</accession>
    <name>A0A132PHQ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lumazine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853368.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29865"/>
    <dbReference type="EnsemblBacteria" id="KWX21866">
        <property type="protein sequence ID" value="KWX21866"/>
        <property type="gene ID" value="AFM11_23780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2114"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="151" mass="16542" checksum="04B23ABB63DDF02C" modified="2016-06-08" version="1">MADTENSGADRPTTTPFFAALVIIVLVVIGIALVNVFQGDGLTDEQQVGRAAVGQNDAMQREDFAAFTDYTCAEQRGTEADFLARQKDSVDQNGERYIDGVTTVQIDGERASATVVYHFKNQPDNKINVETAFVREDGEWRVCSSMGDSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHR9</accession>
    <name>A0A132PHR9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853354.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29900"/>
    <dbReference type="EnsemblBacteria" id="KWX21861">
        <property type="protein sequence ID" value="KWX21861"/>
        <property type="gene ID" value="AFM11_23745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2106"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="121"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="208" mass="22522" checksum="37A0830F85EBFE9A" modified="2016-06-08" version="1">MTESSDPDYDKHGGFPVFEAAEPGPGFGRFVAAMRRVQDLAVSANPDSDTWDDAADRAEELVKLLDPYEAGEGVGPANRVPSLPGAGSLLMPPWTVSKFEADGVELHVQFSRFHVGGNYAVHGGVLPLLFDSVFGMVIHAAGRPISRTAFLHVDYRKVTPIDTVLTARGWVREVEGRKAFVNAELRDADENLLAEANGLMIRLLPGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHY8</accession>
    <name>A0A132PHY8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amine oxidase</fullName>
            <ecNumber evidence="10">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_22695</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58001"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9 10">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852808.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08510"/>
    <dbReference type="EnsemblBacteria" id="KWX21969">
        <property type="protein sequence ID" value="KWX21969"/>
        <property type="gene ID" value="AFM11_22695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1889"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052595">
        <property type="term" value="F:aliphatic-amine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052594">
        <property type="term" value="F:aminoacetone:oxygen oxidoreductase(deaminating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052596">
        <property type="term" value="F:phenethylamine:oxygen oxidoreductase (deaminating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary amine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052593">
        <property type="term" value="F:tryptamine:oxygen oxidoreductase (deaminating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="PTHR10638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="SSF49998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="SSF54416"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0186">Copper</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Cu_amine_oxidN2" evidence="12">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN3" evidence="13">
        <location>
            <begin position="100"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxid" evidence="11">
        <location>
            <begin position="227"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="8">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="9">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX21969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="649" mass="72883" checksum="9820A7084E884598" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI95</accession>
    <name>A0A132PI95_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_21365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852309.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04180"/>
    <dbReference type="EnsemblBacteria" id="KWX22066">
        <property type="protein sequence ID" value="KWX22066"/>
        <property type="gene ID" value="AFM11_21365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1620"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="374" mass="37408" checksum="FEB3D6BA306E76E2" modified="2016-06-08" version="1">MKIVLAPDSFKESMTASQAVSAMREGVLSVLPDAECVGVPMADGGEGTADAVVDALAGEHITVEVSDPLGRPVQAKYGYIPDRKLAVVEMATASGLELVAPAERDVLRASTFGVGQLIANALDHGAAELLIGLGGSATNDGGAGMLAALGAVLADADGAPLPPGGAALARLDRIDLTGLDARLADVRIRIASDVTAPLLGTGGASAVFGPQKGATPADVEVLEAALTRFSEVTETTLGRARPETAGAGAAGGLGFALLEYLDAECDPGVQVIAETVGLEKSVAGADWVFTGEGSVDAQTMLGKTPFGVAEVAGRAGARVVIFAGRVGDDAGVLLDNGVDRLVAITVPGTPLEQALREGPASLTRAAAEVCRAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIJ7</accession>
    <name>A0A132PIJ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852501.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04790"/>
    <dbReference type="EnsemblBacteria" id="KWX22165">
        <property type="protein sequence ID" value="KWX22165"/>
        <property type="gene ID" value="AFM11_21985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1745"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="147" mass="16359" checksum="F50F6BB07C621CB8" modified="2016-06-08" version="1">MDVISIGEAAARLQMSPSALRYYDERGLVCPRMRRGGKRMYGPDELRRLAFLKIVHRLGLPLDTAAAVLDAPSEQWRQTVREQIAELDRVIAQAQGAQQFLTHALHCPTDHPARDCTTMTGALDRLVDGMSVEDLAAEQTGTRWTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ29</accession>
    <name>A0A132PJ29_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_22975</name>
        <name evidence="6" type="ORF">AWC31_08230</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852907.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08230"/>
    <dbReference type="EnsemblBacteria" id="KWX22022">
        <property type="protein sequence ID" value="KWX22022"/>
        <property type="gene ID" value="AFM11_22975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10149">
        <property type="protein sequence ID" value="ORX10149"/>
        <property type="gene ID" value="AWC31_08230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1949"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX10149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="232" mass="25651" checksum="A25CAE5215952FC2" modified="2016-06-08" version="1">MKVLVVEDEPRLASTLTVGLQAEGFVAVTASDGVDGLWQATEHDFDVVVLDIMLPGMSGYEVLRRMRGQGVWTPVLMLTAKDGEYDQTDAFDLGADDYLTKPFSFRVLVARLRALVRRGAPQRPTVLTAGTLSLNPARRTVERCGTSIALTPREYGLLEYLMRNKDTVVTKTEILHNVWDAHYEGPDNVVEVYVGYVRRKIDIPFGTNTIGTIRGVGYRLDSGAYDAPARGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ75</accession>
    <name>A0A132PJ75_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851841.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11120"/>
    <dbReference type="EnsemblBacteria" id="KWX22398">
        <property type="protein sequence ID" value="KWX22398"/>
        <property type="gene ID" value="AFM11_19780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1290"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="36"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="186"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="354" mass="36790" checksum="FC0C9EE177ADCEA5" modified="2016-06-08" version="1">MVATGIDTSRDNRRVVVNSLDDVDIETVEQAEPGAGEARVRTTVVGICGSDLHAACGRHPFIELPYRPGHEAVGVVEAVGPGVDESWIGARVTIEPNLACGHCTQCLAGRYNICRELLVFGCQTPGALADSFVIGADRLVALNDDLDDRHAILIEPLATPVHTVRRAAEVVGDLRDRPVVVIGAGPIGLFTLLAARHAGARVVVADLLESKRARAQRLGAIGTFDPAAPDAVDTALGLLGGPAAVVIDCVSRESSVAQAVELVDKGGAVMIVGVAEGATPVPLGLIQDRELALIGNLMYVREDFTAAVELLSSGAVPVDEIISAEFDFEDSAKAFTASADAENVKVLVTVGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJD6</accession>
    <name>A0A132PJD6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851884.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28505"/>
    <dbReference type="EnsemblBacteria" id="KWX22441">
        <property type="protein sequence ID" value="KWX22441"/>
        <property type="gene ID" value="AFM11_20010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1337"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="160" mass="16817" checksum="CFD2648AA4B52C00" modified="2016-06-08" version="1">MTDKDSNLGADQTSEDVTVETTSVFRADFLNELDAPAAAGTEGAVSGVEGLPSGSALLVVKRGPNAGSRFLLDQPTTSAGRHPDSDIFLDDVTVSRRHAEFRLESGEFQVVDVGSLNGTYVNREPVDSAVLANGDEVQIGKFRLVFLTGPKSDDDSGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJE9</accession>
    <name>A0A132PJE9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852164.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22317">
        <property type="protein sequence ID" value="KWX22317"/>
        <property type="gene ID" value="AFM11_21025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1550"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="155" mass="17470" checksum="3D608D538EBD672D" modified="2016-06-08" version="1">MADTEGSVNVAADEIWDGNYIRARANDPWMRVVDSDDSVGPEITYYGPNDQEITVEWQDNQIAVRTELAPADEIRPDDDVQHPQTGEWVKLHKIAEGTLGTRSAAGERKSRQITFYYEEDSSGLPGEFDSYVEILGEEPVSGTPKKALIWRRVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJV8</accession>
    <name>A0A132PJV8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15235"/>
    <dbReference type="EnsemblBacteria" id="KWX22621">
        <property type="protein sequence ID" value="KWX22621"/>
        <property type="gene ID" value="AFM11_19165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1167"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453076" evidence="3">
        <location>
            <begin position="32"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="89"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="530" mass="56779" checksum="CAAB88A9113CDA66" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK10</accession>
    <name>A0A132PK10_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_19460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851742.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15545"/>
    <dbReference type="EnsemblBacteria" id="KWX22671">
        <property type="protein sequence ID" value="KWX22671"/>
        <property type="gene ID" value="AFM11_19460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1225"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="128" mass="14598" checksum="F3D066A32BB3492B" modified="2016-06-08" version="1">MDWGPTWDFLWHFLIIFAWIAYLLVLFQILGDLFWRDHKTSGWVKAVWVVFLILFPWLTALVYLIARGKGMAERARDAALAAKRDTDAYIREAAGRSPAQEIADAKALLEAGTITADEFEALKTKALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKC9</accession>
    <name>A0A132PKC9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17790</name>
        <name evidence="2" type="ORF">AWC31_11910</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851156.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11910"/>
    <dbReference type="EnsemblBacteria" id="KWX22799">
        <property type="protein sequence ID" value="KWX22799"/>
        <property type="gene ID" value="AFM11_17790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18699">
        <property type="protein sequence ID" value="ORX18699"/>
        <property type="gene ID" value="AWC31_11910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.913"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="63" mass="6769" checksum="23B82643FD1DDB19" modified="2016-06-08" version="1">MNATLTSPELTRADRCDRCGAAARVRAKLPSGAELLFCQHHANEHEAKLIELAAVLEVSPVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKU6</accession>
    <name>A0A132PKU6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850621.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19890"/>
    <dbReference type="EnsemblBacteria" id="KWX22966">
        <property type="protein sequence ID" value="KWX22966"/>
        <property type="gene ID" value="AFM11_16430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.634"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="28391" checksum="0BAB742D19B95D94" modified="2016-06-08" version="1">MTTVDSRDSGTASYPRIDAVSVSLADGVLSVTLNRPDSLNSLTQDMLTAIAEAMEFAATDPQVRVVRLGGAGRGFSSGAGISEEDQNAKSHDAAGVLDAANRAVASIVALPKPVVAVVQGPAAGVGVSLALACDIVLASDQAFFLLAFTKIGLMPDGGASALVAANIGRIRAMRLALLADRLTAADAYDWGLISGVYTAAEFDAAVDKVIAKLRSGPAVALRKTKQAVNAATLTALDGAFAREREGQLQLLVSNDFREGTKAFQQNRRPEFTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL52</accession>
    <name>A0A132PL52_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19375</name>
        <name evidence="4" type="ORF">AWC31_15460</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the non-flavoprotein flavin reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851814.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15460"/>
    <dbReference type="EnsemblBacteria" id="KWX22732">
        <property type="protein sequence ID" value="KWX22732"/>
        <property type="gene ID" value="AFM11_19375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18138">
        <property type="protein sequence ID" value="ORX18138"/>
        <property type="gene ID" value="AWC31_15460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1208"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="155" mass="16773" checksum="27C5C80342025C96" modified="2016-06-08" version="1">MKRVNRQFVTGVTVVTALDGDKPRGLAVNAFASISLEPPTVMVAVQHTSSTHDCLFRAGHLAINILSTDQLDVVNRFAAKSDDKFSGLDWRPGPFGSPLIDRSAATMEVEIRERLQASTHTVFMCRVVHASVGDRDPMVYSAGRFFDGGSLPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL59</accession>
    <name>A0A132PL59_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Suppressor of fused protein (SUFU)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850860.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01670"/>
    <dbReference type="EnsemblBacteria" id="KWX23079">
        <property type="protein sequence ID" value="KWX23079"/>
        <property type="gene ID" value="AFM11_17100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.773"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUFU" evidence="1">
        <location>
            <begin position="34"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="21312" checksum="66ECFBF5CE5321F5" modified="2016-06-08" version="1">MIDVLAAVRARLDAHFTAAGITAEPVSASITFLGTERIDVLRYGPDLRSDFAEVYHYVTLGCSRHPMFDPTELVSDPIHGPRAEVVVSLRGATPTGLAKSLAVLAAAPAVEGLILDADALVDLETPLFESAPFTAFLLGDSDIDDIALPEPLSPVRVLSATPITPTEAAWVRLKGADAMREAWQADGVDVQDPTRRAASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLC3</accession>
    <name>A0A132PLC3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851013.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01425"/>
    <dbReference type="EnsemblBacteria" id="KWX23150">
        <property type="protein sequence ID" value="KWX23150"/>
        <property type="gene ID" value="AFM11_16855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.724"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="31804" checksum="1E97AFA0A7507354" modified="2016-06-08" version="1">MDQGQLADFLRTRREALTPEDVGLPAGPRRRTAGLRREEVAALALISTDYYCRMEQRRAPQPSTEVLASLARALRLSLDERDHLFRLAGHNAPARITTGEHVSPATMRILDRLQDTPAQVMSALGETLVQTPPARALLGEETTYQGFARSVVYRWFTDEASRELYPVEDRAAIGLSYAAGARMAYARDGAGSRAAQIVDDLLSRSAEFAELWKRHDVGHAPELTKRIVHPKLGVLVVQCQILHDAVQMHTLLVFTAEPGTPSHAKLTALGADPQSYLRDLHADARVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLL0</accession>
    <name>A0A132PLL0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,5-dioxovalerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850262.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16260"/>
    <dbReference type="EnsemblBacteria" id="KWX23231">
        <property type="protein sequence ID" value="KWX23231"/>
        <property type="gene ID" value="AFM11_15525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7221"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07129">
        <property type="entry name" value="ALDH_KGSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044151">
        <property type="entry name" value="ALDH_KGSADH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="27"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="532" mass="54490" checksum="8F9EBB267E8927BC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLV5</accession>
    <name>A0A132PLV5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850468.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16685"/>
    <dbReference type="EnsemblBacteria" id="KWX23331">
        <property type="protein sequence ID" value="KWX23331"/>
        <property type="gene ID" value="AFM11_16110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7347"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015402">
        <property type="entry name" value="DUF1980"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09323">
        <property type="entry name" value="DUF1980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03943">
        <property type="entry name" value="TIGR03943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="24809" checksum="95221341D026991E" modified="2016-06-08" version="1">MSRETENALLLLIGVSTAIIAATGAYTRYVKPSLLPYLVATAVLLIALALAAIVRDIRGHADSHDHQHRPGVAWLLLIPIALLAFVVPPAIRPDAASVTEVSTDVLRRPFPPLPDGEAPEVSLPDVLIRVAQDTAGTLDDRTITVTGFTMRDGDRTDLARVVIICCAADAQLARIRLSGPAAADVASYPENTWIRVEGKVPAGQSDSSGRTIPTMTVQRVSRTDPPPHPYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM32</accession>
    <name>A0A132PM32_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849660.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09515"/>
    <dbReference type="EnsemblBacteria" id="KWX23396">
        <property type="protein sequence ID" value="KWX23396"/>
        <property type="gene ID" value="AFM11_13955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6894"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="145" mass="16026" checksum="10566EF355950717" modified="2016-06-08" version="1">MPLVSKTVEIEAPAEKIMSIVADFEAYPQWNPEIKGCWILARYDDGRPSQLRLDVEIQGQSGVFITAVYYPGENQIFTMLQQGDHFKKQEQKFSVVPIGAASLLTVDLEVETKLAIPGPMVKKAIGDTLDHLANSLIARVQQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PME9</accession>
    <name>A0A132PME9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23444">
        <property type="protein sequence ID" value="KWX23444"/>
        <property type="gene ID" value="AFM11_14240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6955"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="379" mass="40454" checksum="BE61A185BDD67274" modified="2016-06-08" version="1">MDNHGYFLATNPGQPHRQLWLVGLDIHTGEPLFSPVTIDSGSNTPKCFLNGPESVLCVADEVRGDEVQSKAWVIDTRTGKVLFNGPTQLHTTPGSGVRVDQVGIYAVAEMLGQGIFGIGPQAETTWLVPGTTKVSTSPRTADADHAPLAIAEDSADGTDQVVVFSLIDGKVITPDIEDGLVPQAAVVYPGGFAIKAVAENSMSVSDAVMFFDETGNRLHETDISGPLSVLSSTLPVVESSPSYSVFGANGTGLIQLPDGLGSDALLIGHRLYVPESTWEGSSKVRRWRQFDLTTGKEGVACRPNMSQYIGNDGSVGVFETSANEVAGASTFAMDLASCEKLWATPVNAESFHRLWRINDTLVELSDDAKELHSLVSHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMT1</accession>
    <name>A0A132PMT1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849001.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02915"/>
    <dbReference type="EnsemblBacteria" id="KWX23646">
        <property type="protein sequence ID" value="KWX23646"/>
        <property type="gene ID" value="AFM11_12635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="164" mass="17442" checksum="99AA3E75E7698EB4" modified="2016-06-08" version="1">MAVTDRGGGVIATRIVLGLTGIAVAGYGAVLLWDNPPVVITRILVWAVVGVAVHDLVFAPLCAALGLAGRRLLPVGWQSPVAVAGLCSVVLVLLAIPVYGKPGLRPDNPTVLDRDYPLGLWISLAVVWLCVPAYYAATRRLPVRQDDVVEHERADDVERQPPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMU1</accession>
    <name>A0A132PMU1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_16275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850533.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16905"/>
    <dbReference type="EnsemblBacteria" id="KWX23362">
        <property type="protein sequence ID" value="KWX23362"/>
        <property type="gene ID" value="AFM11_16275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7380"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="27723" checksum="342F97B2AF421C5D" modified="2016-06-08" version="1">MPDPLSIYTNRRRADSFGAAADDYDRYRPRYPRSLITSLVTGDRTSALDVGAGTGIASEQLRAAGAEVLAVEPDPRMAQVAVGKGVTVEQATFEDWDPRGRHFDLVVFASSFHWVEPRRALHKVATLLKPGGHLALMWNRVTPMTPSRSELDEVYAGFLDPSERPTVDADRTPEVTALIEECGFAVELRRIVEHLHYDATEWVNMVGTYSNVLTLPAHDRLQLRDRLEQRIGSAGVDAENDAIAVVCTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMY9</accession>
    <name>A0A132PMY9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849186.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03305"/>
    <dbReference type="EnsemblBacteria" id="KWX23706">
        <property type="protein sequence ID" value="KWX23706"/>
        <property type="gene ID" value="AFM11_13020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6697"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="346" mass="36659" checksum="662BC80FA70E38EA" modified="2016-06-08" version="1">MTGPEDSHTGTRPISVAELLAKNGTIGAPPVGGRRRRRRGNSDSVTVAELTGEIPIVTDEEPETRSEPETRREPDPALVDTAIVAAVDAEPPARSGRNGAATRTEVEPEPEPEIDPVEADYDAHLQARDADPEPVEFRPRPRRQQYSGPRDYTPTGSGAERMSPDPLDDLDDDDASTSKGSAKLVESTDDDVDTDDDRESYLGSSIGPLFGGQTVADDLARKGRPGVDDDVDDDASTVAAAAVDDRDDLDELDEDDDTEGSPLVRGAWIVGQCIIAVAFGAGLFIAFDQLWKWNTIVALILGVLVILGLAGGVRVVRKTEDIGSTLTAVAVGALVTFGPLALLQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMZ9</accession>
    <name>A0A132PMZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_13085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849217.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03370"/>
    <dbReference type="EnsemblBacteria" id="KWX23716">
        <property type="protein sequence ID" value="KWX23716"/>
        <property type="gene ID" value="AFM11_13085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6710"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="28742" checksum="D410348DC705D427" modified="2016-06-08" version="1">MSPAGKPVGAVTRGTTGYNRLRRSDRWLVHSARVRSALRTAADPLVVDLGYGALPVTTLELAARLQVVRADVRVVGLEIHPERVATARQLAGANGVEFALGGFELAGRRPVLVRAFNVLRQYPVEAVPDAWATMQRQLAPGGLIVDGTCDELGRRCCWVLLDASGPVSLTLACDPFAIERPSDLAERLPKVLIHDNVAGQPIHRLLAAADRAWASVAGHGVFGPRVRWRAMLELLRTDGFSVEPPRRRKRDGVLTVPWQTVAPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN54</accession>
    <name>A0A132PN54_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849368.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03695"/>
    <dbReference type="EnsemblBacteria" id="KWX23768">
        <property type="protein sequence ID" value="KWX23768"/>
        <property type="gene ID" value="AFM11_13410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6776"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025698">
        <property type="entry name" value="2TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13239">
        <property type="entry name" value="2TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="2TM" evidence="2">
        <location>
            <begin position="84"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="145" mass="15908" checksum="631E95F11FE29F58" modified="2016-06-08" version="1">MPATVETTRVGDPEREKTANALGQALTQGYLTMAEYEVRLDAAFHAQTSGELQQLLADLPVAQLRRNDPRRREAQLRAARLSVRIHAGIYLAVSLLMIGIWLAVGLGGGGWYFWPVWPIMGWGIGVASHAIPIWTHGSIKPARIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNF7</accession>
    <name>A0A132PNF7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13230</name>
        <name evidence="3" type="ORF">AWC31_03515</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849597.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03515"/>
    <dbReference type="EnsemblBacteria" id="KWX23878">
        <property type="protein sequence ID" value="KWX23878"/>
        <property type="gene ID" value="AFM11_13230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11318">
        <property type="protein sequence ID" value="ORX11318"/>
        <property type="gene ID" value="AWC31_03515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6739"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="88" mass="10107" checksum="C054B5FE35328D09" modified="2016-06-08" version="1">MHAFRRYLAIQGMTLIFGIVGPIFLVVYFAVQPEPGLKWMYWFGLFITAADVLIALAVTESSLKEDRTPTDVRLAVAFQNFRRRHDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNK1</accession>
    <name>A0A132PNK1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13060</name>
        <name evidence="4" type="ORF">AWC31_03345</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03345"/>
    <dbReference type="EnsemblBacteria" id="KWX23873">
        <property type="protein sequence ID" value="KWX23873"/>
        <property type="gene ID" value="AFM11_13060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11315">
        <property type="protein sequence ID" value="ORX11315"/>
        <property type="gene ID" value="AWC31_03345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6705"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="429" mass="44892" checksum="6CB27ECCF02696F7" modified="2016-06-08" version="1">MRRPGKTAPRANRSLTSTSARYPQSRLLHIVAPSLKVPDAAPAAVFSAVRMRGPIARDAVAQHTQLSIATVNRQVTALLEAGILRERADLAVSGAIGRPRVPVEVNHEPFLTLGIHIGARTTSIVATDLFGRTLDVVETPTPSGPQAAALATLASSARRYLSRWHRRRPLWVGVAAGGVVDSATGYLDHPRLGWSDAPVGPVLAEALGLPVSLASHVDAMAGAELLLSGRRSDAGGAQARTSLYVYARETVGYALSIDGRVHTPASGPGTIAGLPAQSELLGGTGQLESTVSDEAVLTAARKLRIIPAEGPASTLPAVLRAARQGNEKARELLADRARVLGEAVALLRDLLNPDDLVVGGQAFTEYPESMPSVESAFAQRTVLGPRDLRVAAFGNRVQEAGAGIVSLGGLYADPIGAMRRAQTRRSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNW1</accession>
    <name>A0A132PNW1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03490"/>
    <dbReference type="EnsemblBacteria" id="KWX23877">
        <property type="protein sequence ID" value="KWX23877"/>
        <property type="gene ID" value="AFM11_13205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6734"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453208" evidence="1">
        <location>
            <begin position="28"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="94"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="532" mass="57173" checksum="1ECEDEC06EA0BE5F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP36</accession>
    <name>A0A132PP36_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848628.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09815"/>
    <dbReference type="EnsemblBacteria" id="KWX24106">
        <property type="protein sequence ID" value="KWX24106"/>
        <property type="gene ID" value="AFM11_12160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6511"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="146"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="146"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="246" mass="26944" checksum="FC8EF74D3F044227" modified="2016-06-08" version="1">MRAETIPASGEGPHTPDGVNRTVLMVDDDPDVRTSVARGLRHSGFDVRVAASGKEALRLLSNESHDALVLDVQMPELDGVAVVTALRALGNDIPICVLSARDTVNDRIAGLEAGADDYLTKPFDLGELVARLHALLRRASHSDRPSDTMTVGPLTIDTARRLVFVGGERADLTKREFDLLAVLAENAGVVLSRQRLLELVWGYDFDVDTNVADVFISYLRRKLEREGVPRVIHTVRGIGYVLREET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP56</accession>
    <name>A0A132PP56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12280</name>
        <name evidence="3" type="ORF">AWC31_09700</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848689.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09700"/>
    <dbReference type="EnsemblBacteria" id="KWX24126">
        <property type="protein sequence ID" value="KWX24126"/>
        <property type="gene ID" value="AFM11_12280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09209">
        <property type="protein sequence ID" value="ORX09209"/>
        <property type="gene ID" value="AWC31_09700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6535"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="108" mass="11595" checksum="D9736616A89FA00F" modified="2016-06-08" version="1">MSERSVSGWNIAGFVLFVLLLPVAYIEFMIAALAFGMSTDACHDEACDASYHEEAAILTVVIGIVVVLLTTGGAMVYGAMRDKNVFGTPFFGLFGLFVVFLIGRAVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPJ4</accession>
    <name>A0A132PPJ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847042.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24194">
        <property type="protein sequence ID" value="KWX24194"/>
        <property type="gene ID" value="AFM11_09330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5903"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="228"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="460" mass="49919" checksum="B6D54C77F5FECB3F" modified="2016-06-08" version="1">MTEPFVLSAFTMSTVSHGNFGLWRHPEDRTAEYTDIRYWVELAKLLDDGGFDLLFIADAVGQLDVFGGDASAALARAVQTPVTDPLLAVSAMAAATQRLGFGITVSTTYESPYLLARKFSTLDHLTGGRIGWNIVTSLLDSAARNIIGRDRQIPHDERYAIAQEFVEVTFKLWEGSWEPGAVLRDRERGVYTDPTKVHDIGHDGRYFTVPGAHLVEPSPQRTPVLFQAGTSAAGREFASRNAELVFASDPRPDVLRANIDDVRRRAAGHGRDPGSLKFITSVEIVTDSTDSAAQAKADDLAEFHDLEGGLVLLSALSGVDWSTYGVDRPIEQFDTDASRSILAAVTDSDVRQRLTLRDYVGNLGGFGGELFVGSAATVADQLEAYAARTGVDGFNIAYHVTPGSFTDVATYLIPELRKRGRAREAGEPTTLRQRLFGGDTGLLGDAHPAAAFRRNNVTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPL4</accession>
    <name>A0A132PPL4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Fatty acid-binding protein DegV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09455</name>
        <name evidence="3" type="ORF">AWC31_05770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847116.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05770"/>
    <dbReference type="EnsemblBacteria" id="KWX24214">
        <property type="protein sequence ID" value="KWX24214"/>
        <property type="gene ID" value="AFM11_09455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09734">
        <property type="protein sequence ID" value="ORX09734"/>
        <property type="gene ID" value="AWC31_05770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5928"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="278" mass="28914" checksum="13CA8704E77A4AAE" modified="2016-06-08" version="1">MAVVVVTDSSSRLCQEHREQWQIRQVPLHVLDDDTDLRDGVDPVPSDIQDRAKVTTSGATPAELADVYRQALADSGGDGVVAVHISAALSSTYSSAVLAAREFGQAVRVVNSRSAAMGVGFVALAAARTAGAGADLDAVEAAARDAVGHGHAFIVVHRLDNLRRSGRIGTAASWLGTALSLKPLLRLDVDGRLVLSQRIRTISKAHAALVDQVAEVVGDRQASVVVHHVDNRDAADEIGAALTTRLPQIASLTVTDMGPVLAVHVGGGAVGVAVEVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPS1</accession>
    <name>A0A132PPS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MspA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847499.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18625"/>
    <dbReference type="EnsemblBacteria" id="KWX24338">
        <property type="protein sequence ID" value="KWX24338"/>
        <property type="gene ID" value="AFM11_10180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6074"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036435">
        <property type="entry name" value="Leukocidin/porin_MspA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015286">
        <property type="entry name" value="Porin_fam_mycobact-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09203">
        <property type="entry name" value="MspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56959">
        <property type="entry name" value="SSF56959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453479" evidence="3">
        <location>
            <begin position="26"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="23583" checksum="8BBB9786553E691D" modified="2016-06-08" version="1">MLNRFAKLAAVCMLAPIAVAPLASAEPVPPPPDPAAPFAAPAPPAPDTGAVPSAPPGVLDTPDGWHVTVAGSNESQLPVAPLTTAVSSREYLVAGTFTGTITGSGKTKLTGGTLEAGQQIGCGIVSDETEINPGASFSPSIRVPFTGAATDVGFGTGINLQGKVYLKPGTVTIVPIDKKTFKGDSTRVTITGVRIKFDQCAGQSFIRSYATLTASTENTDDVITYLGVTKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPU8</accession>
    <name>A0A132PPU8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_10090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847448.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18575"/>
    <dbReference type="EnsemblBacteria" id="KWX24323">
        <property type="protein sequence ID" value="KWX24323"/>
        <property type="gene ID" value="AFM11_10090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6054"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="153" mass="16393" checksum="2E893208B23E8241" modified="2016-06-08" version="1">MFETPFTVVGTIVTNPVRLRFGEQELYKFRVASNSRRRTPQGTWEPGNSLYVTVNCWGNLATGASASLTKGDAVVVVGHVYTSEYEDKEGVRRSSVEVRATAVGPDLSRCTAKVSPLPKPNAVAEPEPAGTVDDADIQADTEPLDGEALPLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ92</accession>
    <name>A0A132PQ92_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_10640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19155"/>
    <dbReference type="EnsemblBacteria" id="KWX24501">
        <property type="protein sequence ID" value="KWX24501"/>
        <property type="gene ID" value="AFM11_10640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6168"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="6">
        <location>
            <begin position="314"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="429" mass="44331" checksum="DEC81ED8E2291E5B" modified="2016-06-08" version="1">MTTDLTVAAWPGLTPRLLRTEAETLADYTTAGGYGPLDDPHELLDTVTASGLLGRGGAAFPLAVKLRTVRDNGHDAGGAVVIANGEEGEPASVKDRWLLRNRPHAVLDGLRLAAGIIAADRAVVYVSDAAAAHCVQHALGELSDEFGSTAVELVTVAPGYVAGEETAAVHVVNGGPAKPTDKPPRPFEEGVDGLPTLISNVETLTHLAYLHQHGAAEFRSVGTGDSPGTFLATITGAGRPPALYELPHGVAFADLLTLHGVSPAKVSGALMGGYFAGLLNRDILGATLDHETVRGLGSGLGCGAISILTDDCPVAVAAAVLAYFDRENAGQCGSCFNGTAAMAAVATALRDGEATEDDVARLRRWSVVLRGRGACATLDGAANVAASLLAQFLDVVQRHLDNSCRTCKSAAFTAMRPYEVERLEAVMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQD5</accession>
    <name>A0A132PQD5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_07420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845945.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24515">
        <property type="protein sequence ID" value="KWX24515"/>
        <property type="gene ID" value="AFM11_07420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5334"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="12"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="408" mass="42511" checksum="A4433E1CF9D993E2" modified="2016-06-08" version="1">MGDAVAPVPRSWFLRYWTAAAISSFGTAVTAVAMPVLVIQLLGATPLEVGVVNAAQFVPYALLGLIAGVYTDRWRRKPVLVWASVGRALSLAAVPVLWLSGALQIWMLVIALLSFGAFSVFGFAATQSLLPRLVPRTRLVWANARLDQADAAAATLGPGVGGGLVGALGAPVVIVVDAISYLVDAALIASVRVHERQPDSHARNLRAEIGEGLQWTYRHRTLGPLAVSTHVWFFANGAAMTALSLLTLRSLGFTAYTFGMLLTVFGVASLVGASVAAQAGVRFGSGRVIILARIAYPITWILVAVAPATGSGIAVLFVATGLQGLAAGVENSNEMGCWQSLTPDELLGRTNATRRSINRTAAAVGALVAGLFVGLIGDRLTLLGVIIVFVIAALTAALSPLRQASISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQM6</accession>
    <name>A0A132PQM6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846203.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24550"/>
    <dbReference type="EnsemblBacteria" id="KWX24605">
        <property type="protein sequence ID" value="KWX24605"/>
        <property type="gene ID" value="AFM11_07950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5440"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="128" mass="13875" checksum="7A30FCC4964CCF76" modified="2016-06-08" version="1">MRINLTSVLVDDQEKGLRFYTDVLGFVLKHDIPMGVDRWITVVSPQDPDGTELVLEPSGHPAAKPFKDALVADGIPFTSFAVDDVAAEYERLSALGVQFTQKPTAMGPVITAVFDDTCGNLIQIAQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQQ2</accession>
    <name>A0A132PQQ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846375.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00160"/>
    <dbReference type="EnsemblBacteria" id="KWX24661">
        <property type="protein sequence ID" value="KWX24661"/>
        <property type="gene ID" value="AFM11_08270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5505"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10977">
        <property type="entry name" value="CE4_PuuE_SpCDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017625">
        <property type="entry name" value="PuuE/SpCDA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03212">
        <property type="entry name" value="uraD_N-term-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="66"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="33823" checksum="4A02439464F89A9D" modified="2016-06-08" version="1">MSYPRDLIGYGRTPPDPQWPGGAAIAVQFVLNYEEGAENCVLDGDPASETFLSEMTPAEAFPNRHMSMESLYEYGSRAGLWRLLRVFERRQIPLTIFAVARAMQRNPEAVAAFAELGHEIACHGLQWKSYQLIDRDTEREHMAEAVRILTDLTGAAPLGWYTGRDSPNTRELVVQHGGFVYDSDSYADDLPYWVRVAETDHLVVPYTLDTNDMRFASPAGFSNGEEFFAHLRDAFDVLYAEGMAGNPKMLSVGLHCRLVGRPARTAGLERFLDHVQAHENVWLARRIEIAEHWRTVHPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQU6</accession>
    <name>A0A132PQU6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF732 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24708">
        <property type="protein sequence ID" value="KWX24708"/>
        <property type="gene ID" value="AFM11_08555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5560"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453214" description="DUF732 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="2">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="115" mass="11536" checksum="A948FF947CB2D4C7" modified="2016-06-08" version="1">MKISIVGFAATTFAVVALATAAPATADSDEQFLATLEAGGFSWADDAAAQTLINVARGICADLGNGVSAADVITEGVNATGWTPTQTGFFLGAAAAEYCPQHLERAIAEAETLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQU9</accession>
    <name>A0A132PQU9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846419.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00235"/>
    <dbReference type="EnsemblBacteria" id="KWX24675">
        <property type="protein sequence ID" value="KWX24675"/>
        <property type="gene ID" value="AFM11_08345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5520"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="301" mass="32541" checksum="B789C6259AC84230" modified="2016-06-08" version="1">MTEQHIVDVGRGIRLCYEQFGDPDATPVVLIAGLGQQLHSWPDGFVTALADRGYRVTRFDNRDAGRSTHMSYPPPPPLAILRGGNHPDQYHLGDMARDTVGLLDALGYEQAHLVGISMGGMIAQTVAAHHPGRVTTLTSIMSNTGAPRIGRPAPSTWWRMATARPPRTRAEATDAAVKMFRHIGSHGYPFDEAWVRETSGIDWDRDPAASKGTARQLAGIFASGDRTAELAHIDVPTLVIHGDRDRMVHPTGGAATARAIPGARLETITGMGHDLPVGAWPKLLDLITAHTAAHPELKEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQZ1</accession>
    <name>A0A132PQZ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24684">
        <property type="protein sequence ID" value="KWX24684"/>
        <property type="gene ID" value="AFM11_08420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5532"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="76" mass="7982" checksum="E9B4D185B0AE305C" modified="2016-06-08" version="1">MGSTIHFRFYESGGEVHLGIRGYVEHGPGTDAGPVGAPVRAGYTEVAKVTWQPYIDRLAMNIAAAEGAVPVVTKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRF1</accession>
    <name>A0A132PRF1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="4">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pdxT</name>
        <name evidence="7" type="ORF">AFM11_05345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="4"/>
    <dbReference type="EC" id="3.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844961.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12715"/>
    <dbReference type="EnsemblBacteria" id="KWX24875">
        <property type="protein sequence ID" value="KWX24875"/>
        <property type="gene ID" value="AFM11_05345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4258"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="140"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="193" mass="20797" checksum="F02447659EBC8A58" modified="2016-06-08" version="1">MTAHVGVLALQGDTREHLAALREAGAEASTVRRLSELEAVDALVIPGGESTAMSHLLREFDLLEPLRARIAEGLPCYGSCAGMILLATEIADAGVEGRAALPLKGIDMTVRRNAFGRQVDSFEGDIDFIGLDTPVHAVFIRAPWVERVGPDVQVLARAADHIVAVRHGSMLATSFHPEMTGDRRIHKLFVDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRL4</accession>
    <name>A0A132PRL4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_05720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845076.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11580"/>
    <dbReference type="EnsemblBacteria" id="KWX24935">
        <property type="protein sequence ID" value="KWX24935"/>
        <property type="gene ID" value="AFM11_05720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4335"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="60"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="443" mass="46889" checksum="959AB12CDD2740BC" modified="2016-06-08" version="1">MSDSLFDTPGETDLTGPGGAAPVAAPLAVRMRPASLDEVVGQSHLLQAGSPLRRLVEGSGAASVILYGPPGTGKTTLASLISQATGRRFEALSALSAGVKEVRAVIDSARRAAIHGGQTVLFIDEVHRFSKTQQDALLAAVENRVVLLVAATTENPSFSVVAPLLSRSLILQLQPLTAEDIGTVVRRAIADPRGLAGAVEVTDEAVDLLVQLSAGDARRALTALEVAAETGERVTVETIEQSLDQAAVRYDRDGDQHYDVVSAFIKSVRGSDVDAALHYLARMLVAGEDPRFVARRLMILASEDIGMADPTALQTAVAAAQTVQLIGMPEAQLTLAHATVHLATAPKSNAVTTALGAAMNDIRSGKAGLVPPHLRDGHYSGAQKLGNAVGYRYSHDHPDGVVPQQYPPDDLVGVDYYQPTGRGVEREISTRLEKLRAIIRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRL6</accession>
    <name>A0A132PRL6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_07760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846918.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24385"/>
    <dbReference type="EnsemblBacteria" id="KWX24837">
        <property type="protein sequence ID" value="KWX24837"/>
        <property type="gene ID" value="AFM11_07760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5403"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="30"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="26425" checksum="4A266FB15D9560A7" modified="2016-06-08" version="1">MSPADGALSGRQPKAVQSALQVLEAVALAGVGVTAKEIAEQLSMPSATTYRLLNLLVADGYIVRLPDLSGFSLGPRMGVLIDAAVSPNVCTAARDALAELRLSVRFGVHLFYFTNTSVRIADSDDEYPPPAEESVLNHHLHACAVGKLLLAEKREADELLTYPLRALTDDTVTSRSALAEQLETIRGRGVATQTGELRGDSACIAVPVRSPAGALVAALAMSGRADQDQLLLRQVPTLAEYASRLSPLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRR0</accession>
    <name>A0A132PRR0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH--quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845251.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29410"/>
    <dbReference type="EnsemblBacteria" id="KWX25031">
        <property type="protein sequence ID" value="KWX25031"/>
        <property type="gene ID" value="AFM11_06265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4447"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="324" mass="33363" checksum="077DE712BFE5A308" modified="2016-06-08" version="1">MYAIEVAETGGPEVLSYVERPEPSPGPGEVLIKAEAIGVNFIDTYFRSGLYPREVPFIVGTEVCGTVTAVGNDVAALAVGDRVVTANAVGAYADMCVAPADFVAYVPDGVAPEAIASALLKGMTAHYLIKSTYAVQPTDTILVHAGAGGVGLILTQWATSIGTRVITTASTPEKAELSRQAGAVEVLEYPEDPDEFAANIRELTGGAGVAAVYDGVGASTFDASLASLAVRGTLALFGAASGPVPPVDPQRLNSAGSVFLTRPTLAHHTRTPDEFSWRAGELINAIADGSITITVGGKYPLAEAARAHTDLQGRKTVGSIVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRX6</accession>
    <name>A0A132PRX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="13">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_06585</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="13"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845347.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29090"/>
    <dbReference type="EnsemblBacteria" id="KWX25083">
        <property type="protein sequence ID" value="KWX25083"/>
        <property type="gene ID" value="AFM11_06585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4512"/>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="12">
        <location>
            <begin position="620"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX25083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="754" mass="80370" checksum="213A4A4A544619FC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS20</accession>
    <name>A0A132PS20_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_06470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845316.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29205"/>
    <dbReference type="EnsemblBacteria" id="KWX25064">
        <property type="protein sequence ID" value="KWX25064"/>
        <property type="gene ID" value="AFM11_06470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4487"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="246" mass="26181" checksum="5417DB2B07C48570" modified="2016-06-08" version="1">MTAVPALTERVLQVALRDFDLLLGVLAPVLTLLGLNFALQNVIDTGDMSYTEYVLPATIIQAMLLGTVTAADRAAWEQSSGFTMRLRTQPISALAPLAARMVYALIRGSLALVATVITAYALGFRFTGGVLWTAVFLLMPLILALGLSLGADATGTWAHRVGAGQLLLFPQLLLVLVSTGLAPADSFPDWVQPFVQNQPVSQITSTLRGLAGGHVVGTELTITLAWCLGLLVVFGTIAVRLQRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS60</accession>
    <name>A0A132PS60_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847003.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13320"/>
    <dbReference type="EnsemblBacteria" id="KWX24862">
        <property type="protein sequence ID" value="KWX24862"/>
        <property type="gene ID" value="AFM11_09050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5660"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="319" mass="33848" checksum="A136B1C8C79AF4C7" modified="2016-06-08" version="1">MTGGTGYLGAHIVRGLLEAGHEVRLLAIPGVDDAVIERLADAGDITVIEGDIRDTATVDVLLSCCDAVIHAAGVVGTDRRRTELMWQINAYATEAVLTRAVAAGLDPIVSVSSYSALFPPPDGVISRDTPTAPGRSPYAQTKAYADRVARRLQRAGAPVVVTYPSSVVGPAYWTAPGVTERGWAPIVRARVAPRLRGGMQMIDVRDVADVHIRLMQPGRGPRRYVCGGTMVSFDDMIDTLQQGSGLRIRRIPLSPKAFRAIGWCSDLIGGALPLGDGLSYEAAMLLTAATPTDDGHTRAELSIDSWRSPQAAILESIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS75</accession>
    <name>A0A132PS75_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twin-arginine translocation pathway signal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845709.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17430"/>
    <dbReference type="EnsemblBacteria" id="KWX25208">
        <property type="protein sequence ID" value="KWX25208"/>
        <property type="gene ID" value="AFM11_07285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4657"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453540" evidence="2">
        <location>
            <begin position="43"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="397" mass="43144" checksum="4213A8E5CB91E719" modified="2016-06-08" version="1">MPNNTDPRLLARLAANRTTRRRFLGGGAAAAAALALGPTVLAACGSGGDSSSPTTSAAPDDGSPASGTVRISNWPLYMADGFVAAFQTASGLTVDYKEDFNDNEQWFAKVKEPLSRKQDIGADLVVPTEFMAARLNGLQWLNEISESRVPNKKNLRQDLLNSKVDPGRKVTAPYMTGMVGLAYNRAATGRDITKIDDLWDPAFKGRVSLFSDVQDGLGMIMQWQGNSVEEPTSESVQKAVDFVREQKDKGQIRRFTGNDYADDLAAGNIAVAQAYSGDVVQLQADNPDLKFVVPESGGDWFIDTMVIPYTTQNQKAAEAWIDYVYDRANYAKLIAFTQFVPVLSDMTDELAKIDPAIASNPLINPPAEMSNNLKSWAALTDEQTQEFNTMYTAVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS84</accession>
    <name>A0A132PS84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gluconate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07140</name>
        <name evidence="4" type="ORF">AWC31_17575</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845634.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17575"/>
    <dbReference type="EnsemblBacteria" id="KWX25183">
        <property type="protein sequence ID" value="KWX25183"/>
        <property type="gene ID" value="AFM11_07140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17505">
        <property type="protein sequence ID" value="ORX17505"/>
        <property type="gene ID" value="AWC31_17575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4626"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX17505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="484" mass="49396" checksum="4A7FB9BD57B00EA2" modified="2016-06-08" version="1">MNSALSYLAADPELAQPVAAGWQLVLAALAGIALIVVLITITKLHPFLALIFGALAVGVVAGENVGTVLESFGDGFGSTAASVGILIALGAMFAKLLADSGGADEIVDTIVGHASPRALPWAMALVGAIIGLPMFFEIGLVLLMPVIYLVARRSQLSLITVGIPALAGLSVMHGLVPPHPGPLTAIGLLNADLGVTLALGVLVAIPTLILAGPLFGTLAGRWVVLDAPDRFTTTEPSSSGGGTTATGSGPGTATETATETRVRPSFGITIFSVLLPVALMMGKALADIFIEDEENPVRVAFDILGRPLMALLIAVVVGMFTLGLGAKMTRDQIVKSVETSLPPVAGIILIVAAGGGFKQVLVDTGIGTLLAEWAKGANVSVILLAWVLAVLIRLATGSATVATITASSLMLGLVEGMSTGEVSLVVLAVGAGSLFFSHVNDAGFWLVKEYFGMSVGQTIKTWSIMETVLSVAGLIFVLLLGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS96</accession>
    <name>A0A132PS96_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_07365</name>
        <name evidence="2" type="ORF">AWC31_17355</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845749.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25221">
        <property type="protein sequence ID" value="KWX25221"/>
        <property type="gene ID" value="AFM11_07365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17468">
        <property type="protein sequence ID" value="ORX17468"/>
        <property type="gene ID" value="AWC31_17355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4673"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX17468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="111" mass="12976" checksum="A49300321A41E1E2" modified="2016-06-08" version="1">MSHIRRWGAVYLLLILFAGSWIGQFFTQMAEYTSTQQAHGQPFEWSGYWPEFFASTFENWQSEWLQLVFQAILLLGAKHWIFRVDAEDLERIEAKIDELKDAAGLPTPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSA1</accession>
    <name>A0A132PSA1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iditol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07185</name>
        <name evidence="3" type="ORF">AWC31_17530</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845656.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17530"/>
    <dbReference type="EnsemblBacteria" id="KWX25190">
        <property type="protein sequence ID" value="KWX25190"/>
        <property type="gene ID" value="AFM11_07185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17498">
        <property type="protein sequence ID" value="ORX17498"/>
        <property type="gene ID" value="AWC31_17530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4637"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="16"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="362" mass="39390" checksum="2C5C9040FA78C6E1" modified="2016-06-08" version="1">MSQQIPEKMQAVVCHGPHDYRLEEVAVPQRGPGEALIRVEAVGICASDLKCYHGAAKFWGDENRPAWAETMVIPGHEFVGRVVELDDEAAQRWGIAVGDRVVSEQIVPCWECRFCKRGQYHMCQPHDLYGFKRRTPGAMASYMVYPAEALVHKVSADIPPAHAAFAEPLSCALHAVERAQITFEDTVVVAGCGPIGLGMVAGAKSKNPMRVIALDMAPEKLKLAERCGADLTINIAEQNAEQIVKDLTEGYGADVYLEGTGHTSAVPQGLNLLRKLGRYVEYGVFGSDVTVDWSIISDDKELDVLGAHLGPYCWPAAIKMIESGVLPMDQICTHQLPLTDFQKGLDLVASGKESVKVSLIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSB2</accession>
    <name>A0A132PSB2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_05765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845094.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11625"/>
    <dbReference type="EnsemblBacteria" id="KWX25241">
        <property type="protein sequence ID" value="KWX25241"/>
        <property type="gene ID" value="AFM11_05765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4344"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="3">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="4">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="276" mass="28222" checksum="65CE85913CB3D2F6" modified="2016-06-08" version="1">MPDRRPAAVPNNAHKAAVLGSPIAHSRSPQLHLAAYRALGLTDWTYERIECTAEQLPGLVAGLGPEWVGLSVTMPGKFAALQFADQHTDRARLVGSANTLVRNPSGGWRADNTDVDGVIGALGTAGESALVVGSGGTAPAAVVGLAELGVQRITVVARDGGKAERLVDLAGRCGAEGSWCDIGSPGLTDVVAAASVAVSTIPADAAARYAPTLATVPRLLDSIYDPWPTPLAAAVEAAGGEVISGLHMLLNQAFTQVEQFTGKPAPKDAMRAALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSL9</accession>
    <name>A0A132PSL9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Ribonuclease H</fullName>
            <shortName evidence="5">RNase H</shortName>
            <ecNumber evidence="4 5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnhA</name>
        <name evidence="7" type="ORF">AFM11_03390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 5"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844000.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21760"/>
    <dbReference type="EnsemblBacteria" id="KWX25339">
        <property type="protein sequence ID" value="KWX25339"/>
        <property type="gene ID" value="AFM11_03390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2552"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="6">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="155" mass="17203" checksum="A62674D21611CD74" modified="2016-06-08" version="1">MNNDVVVIHTDGGCRPNPGPGGWGAVLRHREHVREMCGGDPGVTSNNRMELTAPIMALEALTRPVAVHLYTDSTYVRNGITKWVLGWERNGWLTAAKLPVKNVDLWQRLQAACARHQVEWFWVKGHSGVGDNELADELATRGMREALDASRDLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT12</accession>
    <name>A0A132PT12_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">(4Fe-4S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_04115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844374.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21040"/>
    <dbReference type="EnsemblBacteria" id="KWX25450">
        <property type="protein sequence ID" value="KWX25450"/>
        <property type="gene ID" value="AFM11_04115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2701"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="344" mass="37640" checksum="16C6256789BAFC0D" modified="2016-06-08" version="1">MAERLPARLADHPTVRAVRARSAAPPPRVIDADWLRQLCLDAGADDVAFAGVDDPALESEREHAGVALPGVRSYISLVVKMNRDNVRSTARSVANQEFHRSGEIINEAAHRITRALEDAGHRAVNPSATFPMEMDRFPGRIWVVAHKPIAVAAGLGVMGIHRNVIHPRFGNFILLATILVGDPISSYGAPLDYSPCLECKLCVAACPVGAIGKDGEFDFLACSVHNYREFMGGFTDWAQTIADSEDAADFRSRVSDSENASMWQSLSFKANYKAAYCLAVCPAGEDVIEPYLDDRKGFMDLVLKPLQDKKETLYVLPNSAAKAHAEKRYPHKTVKVVDSGIRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTB3</accession>
    <name>A0A132PTB3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844652.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25571">
        <property type="protein sequence ID" value="KWX25571"/>
        <property type="gene ID" value="AFM11_04855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2852"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="133" mass="13627" checksum="09515AF98FACBF5B" modified="2016-06-08" version="1">MTAITARSATGTDSLLRLAMRVDAVFVGISGIALLAAAGWFSELTGLPKSVEYGVGIFSVVYGVAVFALAAIEHVRPAGIGTVIANALCTVIAIVAVLTMSLTAAGVVLVIGTGIYTAVMAEWQYVGVRRIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTG8</accession>
    <name>A0A132PTG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_05065</name>
        <name evidence="6" type="ORF">AWC31_20165</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844727.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20165"/>
    <dbReference type="EnsemblBacteria" id="KWX25605">
        <property type="protein sequence ID" value="KWX25605"/>
        <property type="gene ID" value="AFM11_05065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16374">
        <property type="protein sequence ID" value="ORX16374"/>
        <property type="gene ID" value="AWC31_20165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2894"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX16374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="186" mass="19910" checksum="A37BB006A63864C6" modified="2016-06-08" version="1">MSPHREDWLVGDRRAEAAERIYSAAADLAAREGLDALDIDAIAARVHCSRATVYRHAGGKTQIRDAVLSRLAAQIVDEVRRQVDGLTGSRRVVTAVTVALRRIRSDPMFDLLLGSLRGGGAIAGLGQSRVPAGFATELTGLAEDDPVAAAWIVRLVLSLLVWPGADEAAEQEMLRRFVAPAFSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTY0</accession>
    <name>A0A132PTY0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="7" type="ORF">AFM11_00435</name>
        <name evidence="8" type="ORF">AWC31_33550</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842241.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33550"/>
    <dbReference type="EnsemblBacteria" id="KWX25798">
        <property type="protein sequence ID" value="KWX25798"/>
        <property type="gene ID" value="AFM11_00435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11612">
        <property type="protein sequence ID" value="ORX11612"/>
        <property type="gene ID" value="AWC31_33550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.88"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX11612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="105" mass="11278" checksum="D0848351044271BA" modified="2016-06-08" version="1">MKVHKGDTVLVVSGKDKGAKGKVLVAYPERNKVLVEGVNRIKKHTAQSANERGASSGGIVTQEAPIHVSNVMVVDSDGNPTRIGYRVDEESGKKVRVSKRNGKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU96</accession>
    <name>A0A132PU96_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842604.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34160"/>
    <dbReference type="EnsemblBacteria" id="KWX25919">
        <property type="protein sequence ID" value="KWX25919"/>
        <property type="gene ID" value="AFM11_01120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.230"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="71"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="312" mass="33922" checksum="82E26B90198B76DD" modified="2016-06-08" version="1">MDLAVPEVNIAPRWSRGDLGAFVSAAAFDHFLATYRNGMAQLPDFELFDVPTSFGSVRAYRFGGSDDGAPVVLLPGRNASTPMYLTNLGPLLERRTVYGIDLLGEAGLSVQHTKIRGGEDQAQWLDETLGGLGFERAHLLGVSMGGWTAANCAVHRPRRLASITLLDPVFTFARVPLKPVLASVALLAPGVPEKWRRGVMSWISGGADIEAAATEAELIDSGAKDFVLRNPMPKLFTDEQLRSLDVPVLALIAGRSVMLDAQRAAERARRLLPRGQVEIWPAASHAINGEYPNEIAERAGRMWDEVDGIRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUA6</accession>
    <name>A0A132PUA6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ethanolamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_01005</name>
        <name evidence="8" type="ORF">AWC31_34035</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842536.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34035"/>
    <dbReference type="EnsemblBacteria" id="KWX25900">
        <property type="protein sequence ID" value="KWX25900"/>
        <property type="gene ID" value="AFM11_01005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11700">
        <property type="protein sequence ID" value="ORX11700"/>
        <property type="gene ID" value="AWC31_34035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.207"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004757">
        <property type="entry name" value="EtNH_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00908">
        <property type="entry name" value="2A0305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX11700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="470" mass="48921" checksum="2388C23C1AD36CC5" modified="2016-06-08" version="1">MAGVEEHLESADYLQKRQLKSGTAGWVLLAGLGVSYVVSGDYSGWNFGLAEGGFGGLAIAAVIIAGMYLALVLGMAELSSALPAAGGGYTFARRALGPWGGFATGTAILIEYAIAPAAIATFIGAYVESLGLFGITSGWWVYLAAYALFIGIHLAGVGEALKVMFVITAIALVGLLVFSIAALGHFDVANLTNIAVDESAAGSSAFLPHGYLGIWAAIPFAIWFFLAIEGVPLAAEETANPERNVPRGIIAGMAVLLVTCVAVLFLTTGAGGAEEMSDSGNPLVEALGDGTAAKVVNYIGLAGLIASFFSIIYAYSRQLFALSRAGYLPKVLSVTNSRKAPTLALIIPGVIGFILSLTGQGALLLNMAVFGAAVSYVLMMVSHIVLRRREPDMPRPYRTPGGAVTTGFALVVAVLAVIATFLVDRVAAGWCLAVFAAFMVYFAVYSRHRLVANSPDEEFAVLAKAESELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUD4</accession>
    <name>A0A132PUD4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_01145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842616.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34185"/>
    <dbReference type="EnsemblBacteria" id="KWX25923">
        <property type="protein sequence ID" value="KWX25923"/>
        <property type="gene ID" value="AFM11_01145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.235"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="470" mass="50326" checksum="01BC48C2020B1779" modified="2016-06-08" version="1">MDQMAPGADFLQLDPASAPARGLTDWLVDALRGAIADGRLTPGVRLPATRILADELAVSRGVVVEAYRRLADEGLVSGRTGGGTRVLARPVQPSRPTRTVPPSGRPRLPRPRLPIGQGIDLSPGVPDLSAFPRSTWLRAERAVLAEASPEDLGYGDPRGHPRLRDALAPWLGRTRGLRVDPDDILVVAGVAQAAALLAQQLQREGLDTIAVEDPGSRGAVEELEYWGLRAAPVPVDDEGIQVRVLAETGAPAVFLTPAHQFPTGVVLGPQRRRELLAWDGELVIEDDYDAEYRYDRAPVPALHPSAPDRIAYAGSTSKSLAPALRLGWLVAPRRRHPDLVAAKHATDLGSPTVPQLVLARLLESGEYDRHIRLVRARHRARRDALLETLAAALPAARVTGVAAGLHLLAMLPDAVDDVAVADELRDAGVLVHPLSWHRRLPGPPGLVLGYASHPPDRLRAAGAVIARIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUM7</accession>
    <name>A0A132PUM7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_02100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26059">
        <property type="protein sequence ID" value="KWX26059"/>
        <property type="gene ID" value="AFM11_02100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.430"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX26059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="482" mass="50693" checksum="550D8B7BEE4981DD" modified="2016-06-08" version="1">MADIPGQTAPMLEQHTIGFVPASDRHGKVRDLFTLWFGTNIAPLPIVTGALGPSLFGLDLWWSLIAFAVGHVIGGALMALHSAQGPQMGIPQMIQSRGQFGTLGALIIVVIAAVMYLGFFASNIVLAGQSIHGITGAVPVNVGIILGAVGSAVICIIGYRLIHFLNRIGTWVLGLAIAAGFFAILTSDLPADFLSRGGFNFAGWLATVSLGALWQIAFAPYVSDYSRYLPKDVGVASTFWTTYLGCVLGSFLAFAFGAVVALAAPVGMDTMDGVKATTGALGTTMLVLFVLSVISHNALNLYGAVLSIITSVQTFRARWIPTARARVILSVVILVGASIVAIALSADFVSHFVNLVVALLVVLVPWTAINLIDFYIVHKGVYDLESIFRFDGGIYGRYNKAAIIAYVVGIAVQIPFMATSLYTGPVADHLGGADLSWLAGLIVTGPIYLLLVRRGTDPTVAGLDTDGHSAGKTGCLTAQPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUQ8</accession>
    <name>A0A132PUQ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843178.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35055"/>
    <dbReference type="EnsemblBacteria" id="KWX26089">
        <property type="protein sequence ID" value="KWX26089"/>
        <property type="gene ID" value="AFM11_02275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.466"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="256" mass="26643" checksum="F8BF276E8AC4F596" modified="2016-06-08" version="1">MDRQKFDHLFDMTDRTVVVTGGTRGIGLALAEGFVLAGARVVVASRKSDACEAAAAKLRDLGGQAIGVPAHSDNIDDLGALVERTVSEFGGIDVVVNNAANALAQPFGQMTPEAWAKSYDVNLRGPVFLVQHALPHLKASPTAAVLNMVSVGAFNFAPALSIYASGKAALMSVTRSMAAEFTPFGIRVNALAPGPVDTDMMRNNPQEAIDMMVGGTLMKRLATPDEMVGAALLLCSDAGSYITGQVIIVDGGGTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV85</accession>
    <name>A0A132PV85_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_01275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842676.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34310"/>
    <dbReference type="EnsemblBacteria" id="KWX25942">
        <property type="protein sequence ID" value="KWX25942"/>
        <property type="gene ID" value="AFM11_01275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.261"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="33500" checksum="BAE895D7FC29A8F5" modified="2016-06-08" version="1">MTAPTTVPVSVTKLGSRIGARVDGVRLAGDLDDATVAEIRSALLRHKVIFFRDQHHLTDDEQYAFACLLGTPIGHPTISQAMGRESIITPIDSEYAKATRWHTDVTFVPNYPAASILRAVTLPSYGGSTLWASTAAAYDALPEALKHLAENLWAVHSNRYDYAAATIPLTEEQQLMRAAFEKPDFRTEHPVVRVHPETRERTLLAGDFTRGFLGLDPHESQTLFELLQRRITMPENTIRWNWVPGDVAIWDNRATQHRAVDDYDDQHRVMHRVTLTGDVPVDVHGQHSRGLGDAARLVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVF9</accession>
    <name>A0A132PVF9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35655"/>
    <dbReference type="EnsemblBacteria" id="KWX26300">
        <property type="protein sequence ID" value="KWX26300"/>
        <property type="gene ID" value="AFM11_02875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.592"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453378" evidence="2">
        <location>
            <begin position="23"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="386" mass="40019" checksum="6946E3F8896FCE74" modified="2016-06-08" version="1">MLLVVVTTLYASCFRPAGRAAMAEGNTILSADLGGRGPGSLVGAESMPNLISSIDDTGAQSARISYRSSDGDTGTETVVSGTVFVPGGKPPAGGWPTVAYGHGATGIDPSCGPSSYNDLLGQSAPVVELLERGYAVAFPDYQGLGAEGIHPFTDARTAGLNMIDAVRALRATFPGVSKRWAAYGGSLGGGAAWAANEQAAAYAPELEFVGSVAVSPAADVTGVVAKAADGELTLEQAGVLQWLLVSLNRLHPEVNLDDFRRGTASASWQSLSACAFSADRSDALDALNPDDLGPHTPAAAAQLRELLQRWALPQRPLSGPLSVVYGDNDAYLDHEWTTQAVQRACASGGMVNSRLESGKGHLDVDASDQAQWLEDRFAGKAVSRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVW5</accession>
    <name>A0A132PVW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843443.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35570"/>
    <dbReference type="EnsemblBacteria" id="KWX26172">
        <property type="protein sequence ID" value="KWX26172"/>
        <property type="gene ID" value="AFM11_02790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.574"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="445" mass="45830" checksum="C9A61BAC612B8908" modified="2016-06-08" version="1">MTRPAGGPAALWTTIDQLLSSTSNALLLFVLAQVATVSEFGVVSLQIAIVMAWIGFNRGAVGTPVLLVSNLSKREILAEGGYATAFSILSGTGAVMAILAVGWAAGDVAMAVALGVVIPVVLAQDAARYPAIASGRPLVAVVADAAWALGMAGLFTANIAGAGVSVETAILLWGALGLLSAIVLVAGTPIRPHLDQIGSWWKMYSPARIRFGATYATVALSTAATAGLVTVIAGADIAGGLRGASSLFGPIMMLIMAVPMVFVPHVRRTSASPRAQWRLLVKTSSITSTLAIAATALVMAVPTPIGGWILGQTWESAITAVPFIGLECAANCWIVGLYSWLQAQGMGRKLFQLRALHVSLQLGAAAVAAVAVGTLVAVASALAVSCWLMALIGLVVVGRASRRQPTTRPAPQAPSQNSVAHDPARPWPTIDVLDDELVRTAARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAS3</accession>
    <name>A0A132PAS3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000056">
        <property type="protein sequence ID" value="KWX19423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025997282.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19423">
        <property type="protein sequence ID" value="KWX19423"/>
        <property type="gene ID" value="AFM11_35950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6269"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13701">
        <property type="entry name" value="DDE_Tnp_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="12"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="467" mass="49676" checksum="87116791C8DAE88C" modified="2016-06-08" version="1">MKVSHSFAVSSAVFDDDHLVSCAGLVPVMTLAAQTALPQLLRDKVVIAEPRIKSGAANPAPKLSTVIAGMCAGADCIDDLDLVRAGGMKTLFGGVYAPSTIGTLLREFTFGHARQLESVLREHLAGLCARVDLLPGADERAFLDIDSLLRPVYGHAKQGASYGHTKIAGKQILRKGLSPLVTTISTATSAPVITGARLRAGKANSGKGAARMIAQAVATARTAGVTGQIVVRGDSAYGNSTVATACRRAGAQFSLVLTKTRAVAAAIESIDESAWIAVEYPGAVRDPDTGAWISDAEVAETTYTAFTSTDNPMTARLIVRRVKDARFPDALFPVWRYHPFFTDTDEPTVAADITHRRHAIIETVFADLIDGPLAHMPSGRFGANSAWILCAAIAHNLLRAAGVLAGGAHAVARGATLRRKLITVPARLVRPQRRPLLHLPSHWPWADHWLTLWRNTIGHSPPLTATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAZ1</accession>
    <name>A0A132PAZ1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000046">
        <property type="protein sequence ID" value="KWX19476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859896.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31580"/>
    <dbReference type="EnsemblBacteria" id="KWX19476">
        <property type="protein sequence ID" value="KWX19476"/>
        <property type="gene ID" value="AFM11_35665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5868"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="262" mass="28211" checksum="F1A0687CCE4BAB54" modified="2016-06-08" version="1">MMPTPDPLLEVSGLVKTFGQLRALDGVAMKISPGVVTGLIGPNGSGKTTLFNAISGFLRPDMGAVIFNGRDITGAPTHRLARMGLKRTFQNTADFTDMSVLQNLLTSARSAPGERLWRLFASPRGVAAGERILVGRAWDLLDRMGLTELANTRAGDLSIGQGRLLQIARLLMEPPSLLMLDEPSSGLNPDDQHRLSMTVRDLCTDDNMTVLVIEHNMSFINAISDALYVMYDGRVIANGPPAEAISNPVVVETYLGARHATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBD1</accession>
    <name>A0A132PBD1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ORF">AFM11_34875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859508.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11015"/>
    <dbReference type="EnsemblBacteria" id="KWX19641">
        <property type="protein sequence ID" value="KWX19641"/>
        <property type="gene ID" value="AFM11_34875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5324"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="134" mass="13903" checksum="C9BB83482F9BEF4F" modified="2016-06-08" version="1">MSATPIPDDRSYTEEHEWVLIAPGAAVPDEPVRIGITAVAAQALGDLVYLDLPEMGATVTAGEVCGEVESTKTVSELYPPVSGEVTEVNTAAIDDPSLVTSDPYGQGWLFAVAPTDTAVLLTAAEYADKNGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBN5</accession>
    <name>A0A132PBN5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_34370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859219.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11300"/>
    <dbReference type="EnsemblBacteria" id="KWX19728">
        <property type="protein sequence ID" value="KWX19728"/>
        <property type="gene ID" value="AFM11_34370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5218"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="313" mass="31983" checksum="F641C22C30A55BA0" modified="2016-06-08" version="1">MRSLIIFALVGLGAQIVDGALGMAFGVTASTLLVLSGVAAAQASAAVHLAEVGTTLASGLSHWRFKNIDWKIVLKLGVPGAIGAFLGATVLSSLSTEDAAPLMAGILLAIGVYVLLRFSLRTPPAFRSGSTPHTAKFLTPLGLFGGFIDASGGGGWGPITTSTLLSRGKTAPRTVIGSVSASEFLVAVSASLGFLVGLREDFLHNIPIVLGLAAGGVIAAPLAAWLVSKVSPALLGTAVGGVIVLTNAQKLLKYFGIHGAASTAIYTTIAVLWAGLVVYAWRTSRAPEYLPEALDSEAPAEEELADEPDTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBR5</accession>
    <name>A0A132PBR5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_33950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858984.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32500"/>
    <dbReference type="EnsemblBacteria" id="KWX19758">
        <property type="protein sequence ID" value="KWX19758"/>
        <property type="gene ID" value="AFM11_33950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5127"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="416" mass="44515" checksum="FBB4E38D718DE09E" modified="2016-06-08" version="1">MIGTAADRLVGLVRYGYRRRAWLSAAGLVMVLVVATGYLLFGALRVNPFASQYKVTVQLPESAGLLPNQDVTLRGVPVGRVQQLDITPSGVNALVNVKSTVKIPESSAVRVSGLSPAGEQYIDFVPESDRGPFLADGSVIALGKATVPVSLAELLANADGALAQTDTDKLELIRRELSLSDAGPQKLADIIDGGTFLLSTLDSVLPETSSLLRSSRSVFTLVADKNAGIDVASDNLTESFVGINKMRDGYRRLTDQAPGTLTSVDNLFIDNSDTMVQLLGNLTTTSRLLYLRVPALNALFPSYRTSLLDALGTTMHDHGLWATGDIYPRYSCDYGTPRLPPSSADYPEPFMYTYCRDDHPGILIRGAKNAPRPAGDDTAGPPPGADLGRQTDPTPKGRYTIPTPYGGPTLPIEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBY4</accession>
    <name>A0A132PBY4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858918.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07515"/>
    <dbReference type="EnsemblBacteria" id="KWX19843">
        <property type="protein sequence ID" value="KWX19843"/>
        <property type="gene ID" value="AFM11_33870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5112"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="130" mass="13974" checksum="1810A9FD5DE45921" modified="2016-06-08" version="1">MIVVGYSADPFGRAAIEHGIEEAKLRNTGLLVINATSGDAYVDARFARSGEIHDVEEQLRESGVSFELRQPVGVDAAEELLNVMDSPDADLLVIGIRHRSPVGKLLLGSVSQRLLLECLKPVLAVKPKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBZ0</accession>
    <name>A0A132PBZ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFM11_33845</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858903.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07540"/>
    <dbReference type="EnsemblBacteria" id="KWX19838">
        <property type="protein sequence ID" value="KWX19838"/>
        <property type="gene ID" value="AFM11_33845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5107"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02791">
        <property type="entry name" value="MopB_CT_Nitrate-R-NapA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041957">
        <property type="entry name" value="CT_Nitrate-R-NapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14 17" id="KW-0408">Iron</keyword>
    <keyword evidence="15 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="16" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="20">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="817"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="982"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KWX19838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1345" mass="146157" checksum="DE9E49400EF45628" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC51</accession>
    <name>A0A132PC51_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859630.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19562">
        <property type="protein sequence ID" value="KWX19562"/>
        <property type="gene ID" value="AFM11_35050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5739"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="197" mass="20630" checksum="C8C89E1D9F0F3B8C" modified="2016-06-08" version="1">MPKTSKSLRDLIEIAVTRHKGASGRRLADIAQQAGHDISHATLNRLRQGSYASRPTDASIRAIAYLAEVPEAVAFAAVGVRPPMSEQYQLPAEAQRMDTRQRRALDELLRAFVVPREPVTMQGFGALLSARDQLDAAVAATDTEDGPVIAAARAVIAAIDDATLSLFGGAGNGSDDLSGDPHWPPADGAAPAVSVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC77</accession>
    <name>A0A132PC77_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858753.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02210"/>
    <dbReference type="EnsemblBacteria" id="KWX19904">
        <property type="protein sequence ID" value="KWX19904"/>
        <property type="gene ID" value="AFM11_33540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5041"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="237"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="435" mass="45836" checksum="AA5D807169E1DC40" modified="2016-06-08" version="1">MVAISETGPPAAPAPAEPLAKPRNIGVVPTASLITGAALALVWFWIPLSILIIGLSSIPSVIGFVLAAIVFIYLMRGVEWVERSRSEAVFGLEIGIPPRRLSHYTGLQRWAHQQWLDISSARFWKGVAHHYLRMLYDMLAAGIAFGLLLFAFVGPAAATAIRQSDGDAGLMFVSPPIAWLLAIVAVAAAAAILVFAPALDAAIDRWLLSPSPTAALQYQVSALADARQGAVSSAQTERHRIERDLHDSVQPRLVSLAMTIGLAQTKLDSDLPAAKSLIAEAHDDAKSALVELRNVVRGIAPTILADRGLDAALSSVVQRAETSGVPTTLHVDLPRRLPDEVESVAYFVVAEALTNIAKHAEATQAVVTVRLDDAANVLHVSVFDDGRGGAVIEAGENATGLRGLDERVRAAGGSFGVTSPVTGPTIVTAVLPCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC80</accession>
    <name>A0A132PC80_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_33140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858517.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17085"/>
    <dbReference type="EnsemblBacteria" id="KWX19941">
        <property type="protein sequence ID" value="KWX19941"/>
        <property type="gene ID" value="AFM11_33140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4960"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="264"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="387" mass="40470" checksum="CF8F94DAA0491106" modified="2016-06-08" version="1">MGNPVIVEATRSPIGKRNGWLSGLHATELLGAVQKALVEKAGIEAGDVEQIIGGCVTQYGEQSNNITRVGWLTAGLPEHVGATTIDCQCGSAQQANHLVAGLIATGAIDIGIACGIEAMSRVGLGANAGPDRSLIRASSWDIDMPNQFEAAERIAKRRGIARADVDALGLASQRKAKQAWAEGRFDREVSPISAPVLDENKQPTSEWAPVTRDQGLRDTTAEGLASLNPVLEGGVHTAGTSSQISDGAAAVLWMDEDKARALGLKPRARIVAQANVGAETYYHLDGPVQSTARVLEKAGMKLGDIDLVEINEAFASVVLSWAQVHDADMDKVNVNGGAIALGHPVGSTGARLITTALHELERTDKSTALITMCAGGALSTGTIIERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCG1</accession>
    <name>A0A132PCG1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secretion protein EccA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_33005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858405.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32450"/>
    <dbReference type="EnsemblBacteria" id="KWX20025">
        <property type="protein sequence ID" value="KWX20025"/>
        <property type="gene ID" value="AFM11_33005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4932"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023835">
        <property type="entry name" value="T7SS_EccA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03922">
        <property type="entry name" value="T7SS_EccA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="338"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="589" mass="64286" checksum="E7EDDB0D39620FFF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCY3</accession>
    <name>A0A132PCY3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">potA</name>
        <name evidence="10" type="ORF">AFM11_32170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857926.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31680"/>
    <dbReference type="EnsemblBacteria" id="KWX20195">
        <property type="protein sequence ID" value="KWX20195"/>
        <property type="gene ID" value="AFM11_32170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4761"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015417">
        <property type="term" value="F:ABC-type polyamine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="12"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX20195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="377" mass="40918" checksum="E5F1F86CF7826DA5" modified="2016-06-08" version="1">MSDDRSPQGASITMRNLTKRYGDFTAVDSIDLEARPGEFLTLLGPSGSGKTTTLNMIAGFADVTSGELLIDGRAVTNLPPYKRNIGMVFQHYALFPHMTVAQNVEYPLRQRKIAAAERRTLVAQALEMVGLGHLGKRRPKELSGGQQQRVALARAMVYSPRVLLMDEPLGALDKKLRDSLQLEIKRIHSDLGTTFVYVTHDQDEALILSDRIAVFNNARIEQIGSPTELYEYPNTLFVAQFLGESSLFHGVSDGGREADSNGHRLSAVRGPEHARGAGVAVVVRPERIRIEPDGPRPSSVNAVPGTVVQHIYLGNSRKVEVRLDDDTIVLVRESAGAISSASAGDRIWLTFHPDDAAILASGDPQPAAPKQAATASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE37</accession>
    <name>A0A132PE37_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857446.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25480"/>
    <dbReference type="EnsemblBacteria" id="KWX20232">
        <property type="protein sequence ID" value="KWX20232"/>
        <property type="gene ID" value="AFM11_31325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4171"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="50"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="586" mass="62871" checksum="5F26C3B381CEAADF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE74</accession>
    <name>A0A132PE74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857571.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20272">
        <property type="protein sequence ID" value="KWX20272"/>
        <property type="gene ID" value="AFM11_31555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4216"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="147"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="298" mass="30985" checksum="CF0AE8606CC14C1F" modified="2016-06-08" version="1">MSFRGWLLFGAMSIIWGIPYLLIKIAVEGVSVPVLVLARTAVGAAVLLPLAMSRAAWAPVLRHWKPVLAFAFFEIIAAWLLLTDAERHLSSSMTGLLIAAAPIIAAVLDRVTGGERLGAKRIVGLGVGLSGVAVLAGPGLAGGHAWPIAEVLLVATCYAIAPLVAARYLGDVPTLPLTAACLTVAALIYATPAALTWPDEMPSERVLFALAALAVICTALAFIVFFALIREVGAARALVFTYVNPAVALAAGVIVLGEPLTAWNVAGLALILTGSVLATRKPREPEPELAEPSRAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEC4</accession>
    <name>A0A132PEC4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016894733.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20689">
        <property type="protein sequence ID" value="KWX20689"/>
        <property type="gene ID" value="AFM11_29135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3711"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="4">
        <location>
            <begin position="59"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="520" mass="59223" checksum="1052F710260F696B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEE7</accession>
    <name>A0A132PEE7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_29820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856567.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25160"/>
    <dbReference type="EnsemblBacteria" id="KWX20597">
        <property type="protein sequence ID" value="KWX20597"/>
        <property type="gene ID" value="AFM11_29820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3856"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="13"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="362" mass="37343" checksum="25175A8FBB2718C7" modified="2016-06-08" version="1">MLTARAAVLLDAGADPQLTDVQIRPPVEDEVLVKIDAVGICHTDVSVAARFRKLPMVFGHEGAGTVVEVGPKAQRRVGERVVLTFASCGACTNCVADRPAYCDQSTDLNMRGSRRDESSALRLDGAPIGGGFFGQSSFATYAIARSRNAVVVPESIDPALAAPLGCSVQTGVGAVLNVLASRPEDAVVVFGAGAVGLSAVMGARIAGCRTIVAVDPIEQRRTLATELGATATVDPTATDAAAAVLELTGGAAGAVDTTARADVIASAVAVLRSRGTLALLGLGALTAELPVALIMGRGLTVRGVVEGDSEPHTFIPRLVDFYRTGELPLDKLVTSYPFGDFDRVWAAAKAGEVVKPVLVTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEM7</accession>
    <name>A0A132PEM7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-hydroxycyclohexanecarboxyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040173.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20744">
        <property type="protein sequence ID" value="KWX20744"/>
        <property type="gene ID" value="AFM11_29155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3715"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="251" mass="26153" checksum="1EA9D485BBD1008B" modified="2016-06-08" version="1">MQARVAVVTGAARGIGREIALALGRQGRHVAVVDLRDHEAKETAATITAAGGTAVPVAVDVTDPASVKEGLNEVRQKLGSISILVNNAGWDELKPFVDTDEEFWQRVIEINYKGVLRTTHDVLPAMIEAGWGRIVNIGSDAGRVGSSLESVYSGAKGAVIAFTKTIAREVARAGVTANTVCPGPTDTPLLQEIVRGQADADKVIGAMTRAVPMKRLGRPEEVAAAVAFLASDDAGFITGQTLSVSGGLTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEM9</accession>
    <name>A0A132PEM9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_28530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856156.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32785"/>
    <dbReference type="EnsemblBacteria" id="KWX20785">
        <property type="protein sequence ID" value="KWX20785"/>
        <property type="gene ID" value="AFM11_28530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3584"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018818">
        <property type="term" value="F:acetylene hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02781">
        <property type="entry name" value="MopB_CT_Acetylene-hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037949">
        <property type="entry name" value="MopB_CT_Acetylene-hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="789"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="1045"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1127" mass="122558" checksum="DFBFA19813F89A09" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PES2</accession>
    <name>A0A132PES2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_28720</name>
        <name evidence="7" type="ORF">AWC31_32950</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856238.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32950"/>
    <dbReference type="EnsemblBacteria" id="KWX20813">
        <property type="protein sequence ID" value="KWX20813"/>
        <property type="gene ID" value="AFM11_28720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11507">
        <property type="protein sequence ID" value="ORX11507"/>
        <property type="gene ID" value="AWC31_32950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3623"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="16"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="142" mass="14835" checksum="D9F5A74E806691BE" modified="2016-06-08" version="1">MALREFSSVKVGDTLPEKIIPLTRGDLVNYAGVSGDLNPIHWDDEIAKQVGLDTAIAHGMLTMGLGGGYVTSWVGDPAAVKEYNVRFTAVVPVPNDGVGAEIVFNGRVKSVDPDDKLVTIAISATAGGKKIFGRAVATAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF69</accession>
    <name>A0A132PF69_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-carboxymethyl-2-hydroxymuconate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856368.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20857">
        <property type="protein sequence ID" value="KWX20857"/>
        <property type="gene ID" value="AFM11_28625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3605"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="206" mass="21896" checksum="B4065989A9230557" modified="2016-06-08" version="1">MRTIWGTARNFPVGASLPPREPQLFVKNSHAMIGPGEPLRLTGSVAQRVVAEGELAILIGEQCRDLGSVSDARAVIAGYCIANDVTARDLQEIDDHWSRGKGLDGFCPLGSQVVAPDDVPAWDEVVIRTWVDSALVQEEAVAAAFVGPEELVRWASKQFTLHPGDVFLLGTPDYLPSGDESGAVLRPGCTAKVEIAGIGSLVTPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFJ1</accession>
    <name>A0A132PFJ1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_27070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855280.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06915"/>
    <dbReference type="EnsemblBacteria" id="KWX21044">
        <property type="protein sequence ID" value="KWX21044"/>
        <property type="gene ID" value="AFM11_27070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3288"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017221">
        <property type="entry name" value="DUF34/NIF3_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037489">
        <property type="entry name" value="UCP037489_NIF3_YqfO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="372" mass="38651" checksum="237C98FDB821E2FC" modified="2016-06-08" version="1">MSARLADVIAVLDAAYPPRLAEDWDSVGLVCGDPDEPIDSVTVAVDATESVISEVPERGLLLAHHPLLLRGVDTVAASTAKGALIHRLIRTGRALFTAHTNADSASPGVSDALADALGLTVEGVLSPVAAGPDLDKWVVFVPAADAEALRAALFAAGAGRIGDYSHCSWSVTGTGQFLPHDGASPAIGEVGSVERVAEDRVEVIAPARLRSKILAAMRAAHPYEEPAFDIIALAPIPGHVGIGRVGSLARPEPLSAFVSRVCTALPATSWGVRASGDSDAMVSRVAVCGGAGDSLLGAAAAADVQAYVTADLRHHPADEHRRASDVALVDVAHWASEFPWCAQAADVLRRHFGDTLPVRVSTVRTDPWNVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFK4</accession>
    <name>A0A132PFK4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06705"/>
    <dbReference type="EnsemblBacteria" id="KWX21128">
        <property type="protein sequence ID" value="KWX21128"/>
        <property type="gene ID" value="AFM11_26855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3242"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="27736" checksum="1072000436B6B01E" modified="2016-06-08" version="1">MDLRGKRILVTGASSGIGRELALALAGKGATLAVAARRQELLDRLADELFDTGSARPIVLRADLALPGAAADLGARALKALGGVDIVINNAGANLTGAQSSVADSEAARRVFEVNLWSPLALTAALLPAMHAAGSGTIVNVTSTVQAVPLPLLGYYAASKAALAQATRSLRLELAETPIGVVEVVPGSTDTALRDIDELPWKTAPPRTAPPVSPASTAAAVVRALQRGATRVVYPSYSLLPLEVPAIGRLVAAIGGRRVNTLGALDLEGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFV0</accession>
    <name>A0A132PFV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26490</name>
        <name evidence="3" type="ORF">AWC31_22845</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854951.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22845"/>
    <dbReference type="EnsemblBacteria" id="KWX21205">
        <property type="protein sequence ID" value="KWX21205"/>
        <property type="gene ID" value="AFM11_26490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15427">
        <property type="protein sequence ID" value="ORX15427"/>
        <property type="gene ID" value="AWC31_22845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3168"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="125" mass="13834" checksum="9DE8F9FFD8E88744" modified="2016-06-08" version="1">MPHRFTASPEQPLYEIKANLFKALAHPARIRVLEILSASGQPTPVSDILAETELEPTLLSQHLAVLKRHHVVSGQRVGNAVFYELAHPKISELLVIARTFLADTLGVQRDQLATLRSLPPIGHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG87</accession>
    <name>A0A132PG87_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854488.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36185"/>
    <dbReference type="EnsemblBacteria" id="KWX21323">
        <property type="protein sequence ID" value="KWX21323"/>
        <property type="gene ID" value="AFM11_25710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3006"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="294" mass="30476" checksum="A346A4CE2A98CA0F" modified="2016-06-08" version="1">MTPKSDAGRPYLVGLVGTGVGPSLTPALHMAEGRAQGLDYVYRTIDLNACGIAPHQIGEVLAWARTLGYDALNITHPCKQLVLDHLDDVDETARTLGAVNTVVFDCGRAIGYNTDTTGFAHGFTGGLPGVPMASAVLVGAGGAGSAVGDALLRIGVGHLTVVDLDVDRAATLAHELADRHALSRVDASSLDKLSALLPDRDGVVHATPTGMAEHPGLPFDAALLHPGLWVADIVYRPLDTALLQAARAAGCRTLDGGHMAVYQAVDAFALITGLTPDADRMSAHFRDLVAQTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGG9</accession>
    <name>A0A132PGG9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_24845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854035.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27100"/>
    <dbReference type="EnsemblBacteria" id="KWX21448">
        <property type="protein sequence ID" value="KWX21448"/>
        <property type="gene ID" value="AFM11_24845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2330"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="308" mass="31289" checksum="469CEE28AB4DB443" modified="2016-06-08" version="1">MNTSMITEIVSSGVAFAIPLLLAAAGESISERAGVLNLSMEGMMLTGAFAGVLTAVSTGSAILGAVAGIVAGLIFGLAQALWSVRFRADQIVVGIAANALALGLTTFGARTLLGDGKGHDVPAFGDVHIPVLSDLPVIGPALFGQTLLGYFCVVAIVALTVLFSNRTMTGMRIDAVGEDAVSAGWTGLPVNRIRVVGVLVASGAGGLAGAQLALSEVRAFSENMTAGMGYLAVVAVIAGHWRVTGILWAALFFGVARALQFALPAVGVHIPYAVLVMLPYVIAIVAISGFVGGRKAPSCLTVPYVGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGQ8</accession>
    <name>A0A132PGQ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24720"/>
    <dbReference type="EnsemblBacteria" id="KWX21397">
        <property type="protein sequence ID" value="KWX21397"/>
        <property type="gene ID" value="AFM11_25560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2975"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IclR-ED" evidence="1">
        <location>
            <begin position="103"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="211" mass="23127" checksum="2043A81304786C39" modified="2016-06-08" version="1">MAKKLGAPVSSVQGLVNGLVATGYLDEHNRRYVLGSAPYLLNRMAGRQPVSTVTHADLSHIHERSGLTTVLSIAVGPNIFYVDYCSSDPRFAYLAENYVQRSLIRTSAGWVLLAGMDKRDQWAYLRGVEDAERPLIDRFFATLPQIEQTGVCAAPNASEHGDGISIAVRENDKTVAAVGIISTHEEISSRRDELTAILTDQARQWSARQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGZ1</accession>
    <name>A0A132PGZ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_23965</name>
        <name evidence="8" type="ORF">AWC31_24190</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853515.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24190"/>
    <dbReference type="EnsemblBacteria" id="KWX21596">
        <property type="protein sequence ID" value="KWX21596"/>
        <property type="gene ID" value="AFM11_23965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15650">
        <property type="protein sequence ID" value="ORX15650"/>
        <property type="gene ID" value="AWC31_24190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2151"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453264" evidence="4">
        <location>
            <begin position="31"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="167"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX15650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="268" mass="28156" checksum="1AA3E460EBF20B5A" modified="2016-06-08" version="1">MRAIIQGVLALVVVTMAVSAGTTSVDPAAASQPLNSSIESIAPKQGDVVGVGHPVVVTFSKPIANRSAVERAIAVKSTPARTGKFEWLESNVVQWVPDKFWPAHSTVSLSVSGKLAQFQTGAAVVGVADISDHTFTVTIDGIGAGSPIPLPAPHHLPRRGEEGVLLASMGRPEYPTPVGTYTVLEKERSVTMDSSSVGIPVDAADGYLLEVDYAVRITRRGIFVHSAPWAVASMGLENVSHGCISLIPAAAEWYFNTVNVGDPVIVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH47</accession>
    <name>A0A132PH47_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_25705</name>
        <name evidence="6" type="ORF">AWC31_36190</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854484.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21322">
        <property type="protein sequence ID" value="KWX21322"/>
        <property type="gene ID" value="AFM11_25705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12053">
        <property type="protein sequence ID" value="ORX12053"/>
        <property type="gene ID" value="AWC31_36190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3005"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041474">
        <property type="entry name" value="NicS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17938">
        <property type="entry name" value="TetR_C_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX12053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="214" mass="24611" checksum="DCA203E62DEA3139" modified="2016-06-08" version="1">MAAKPKAELQRDAERTRAELLEVATEVFAESGYSGARVDEIAERTRTTKRMIYYYFGGKEQLYLAVLENAYRGIRAAEQRLRVDHANPVIAIRRLAEVTFDHHIAHDAFIRLVSIENIHRGEFIRQLRELPDLSRPATSLLDEILRDGREAGVFRDDVDALDVHLVISSYCVFQVANRYTFGYLFDVDLTETSQRAHLRRMLGDMVVGWLTSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH86</accession>
    <name>A0A132PH86_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854362.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27795"/>
    <dbReference type="EnsemblBacteria" id="KWX21567">
        <property type="protein sequence ID" value="KWX21567"/>
        <property type="gene ID" value="AFM11_25435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2450"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019923">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03621">
        <property type="entry name" value="F420_MSMEG_2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="309" mass="32788" checksum="5AF5D8CC6173F7B8" modified="2016-06-08" version="1">MRFGLHTALPRATDFAEFAAEVESSGFDVLTIPDHLVASLSPFAGAATACAHTTRLHTGTLVLNNDLRHPVETARESASVAMLSSGRFELGLGAGHMKSEYDAAGLKFDRGGVRVDRLIEAVEVIRPLLNGTAVDVDGAHYCVRAGAGELVAAPGVAVPLLIGGNGTRVLQLAGRVADIAGLAGFSHNRDATEVRLTHFGPAGLLDRIAVVRDAAGDRFDAIELNGLIQVVIRTDDRAAAAEAFAAPLGADPELVLESPFVLLGTYEQMAEALSERQRRFGISYWTVFDAWPGRESAMPDIAEVIKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH96</accession>
    <name>A0A132PH96_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853456.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21577">
        <property type="protein sequence ID" value="KWX21577"/>
        <property type="gene ID" value="AFM11_23860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2130"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453033" evidence="1">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="145" mass="15105" checksum="FF3E3BCC60778AF7" modified="2016-06-08" version="1">MTRFRVAGALAVALTVPWLWAATAQAESFAQLDRVPVVAAATCAGNVSAEAQVTPVQIGDRVEDGVRVAIHYDAGIYDGSCALTVEATWRNLDTGASGSRDITAVSTIDGHYGFIGYANTTFETGGGTVVVTLSSHPGTEMRINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHA9</accession>
    <name>A0A132PHA9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21720">
        <property type="protein sequence ID" value="KWX21720"/>
        <property type="gene ID" value="AFM11_24180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2195"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453345" description="Cupin_2 domain-containing protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="65"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="157" mass="16436" checksum="1BE2A11C33C4BE85" modified="2016-06-08" version="1">MDSWRLIVKVVLARTVGCIGVVLASSLLFAGVVAAHGPDEAGVVQVAFDQPVTNIPGESLVALEVSYGPGAKDLSHRHADSAFIMAYVLSGAIRSQVAGQPPRVFKAGETWQEVPGDHHVVSENASATEPARLLAVFVVDSSQSQALTTFDADSGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI29</accession>
    <name>A0A132PI29_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852796.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08545"/>
    <dbReference type="EnsemblBacteria" id="KWX21963">
        <property type="protein sequence ID" value="KWX21963"/>
        <property type="gene ID" value="AFM11_22660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1882"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="374" mass="39835" checksum="4BEED684D0F64EE7" modified="2016-06-08" version="1">MTEILIAGAGIGGLTTALALRARGIPATVIERARDVRPLGVGINLLPHAVRELCELGLGDALADIAVAPAAISYYDASGTLLFREPRGIDGGYGHPQYSVHRGELQMLLLSALGPDGVRTGTQLIGFDDDGAHVTVRTSAGDFDAAALVGADGIHSAVRAQLHPGADPLQWSGVRMFRGAAPGEPFLDGRTMAIVKDDAAELVVYRIGGGLTNWVVLLPESEPGPLPGDARWNQPGDRSEVLAHLARWDLGWLDVADLIARTETVLEYPMVDRDPLPWWGAGRVTLLGDAAHPMYPVGANGGSQAIVDARVLADELARDVETGLRRYEDIRGPETADVVAANRAMHHIGTSRPEELARVTADYRRDTNADRSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI76</accession>
    <name>A0A132PI76_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852798.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08540"/>
    <dbReference type="EnsemblBacteria" id="KWX21964">
        <property type="protein sequence ID" value="KWX21964"/>
        <property type="gene ID" value="AFM11_22665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1883"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="225" mass="24523" checksum="6AA40D590CC26C1A" modified="2016-06-08" version="1">MTTYVLVPGACHGRWYYDDLAARLRDHGHRVLAITLTGVAERAHLAHAGVNLETHIADVLAELGAQQVTDAVLVGHSYGGMVITAVADRVAAQVDSLVYLDAFVPADGDSCWNLVTDDLRGWYAGVDATGYGVPPLPFFDKRATAHPLASLMQPIRLTGDLSEFRRRVYVYAAQWDGEPPFAALFERLSQDPSWTTHALDSTHNLLAGHTDEVLRILLGVAGHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIH5</accession>
    <name>A0A132PIH5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853176.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28140"/>
    <dbReference type="EnsemblBacteria" id="KWX21802">
        <property type="protein sequence ID" value="KWX21802"/>
        <property type="gene ID" value="AFM11_23415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2038"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="175" mass="17983" checksum="E30A3E6A78AA152A" modified="2016-06-08" version="1">MANTLLDFVMSLVRDPDAAARYAADPAQAIADAHLTDVTSADVNNLIPVVSESLSMTAPTGGLDAFGAESAGNVWASGAATAAFDAFGDHVPVDAGPDVVSQVIEQPTETVASGLDSLTDTGLVSDPFDEASLQVTEPVIDDAITTDPVIADDWAQPVVDDQHHTDGVGGFDIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIH8</accession>
    <name>A0A132PIH8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathionylspermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852305.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04170"/>
    <dbReference type="EnsemblBacteria" id="KWX22064">
        <property type="protein sequence ID" value="KWX22064"/>
        <property type="gene ID" value="AFM11_21355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1618"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSP_synth" evidence="1">
        <location>
            <begin position="12"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="387" mass="44200" checksum="43303ABCAD309103" modified="2016-06-08" version="1">MRRQRSSPRAGWEQIVADQGMCYGTPARDASGADRPYWDESVHYVFDMDEVLSIEASVEVLHSMCLEAVEQVVLTERYRDFGLPEWSWEHIEKSWRRSDPHLYGRFDLRYDGRRPPVLLEYNADTPTTLLEAAILQWHWKTDVFPDDDQWNSLHERLVARWAEIRDRLPGSETHFTWSGAEMTGEDNVTVAYLQECAAEAGLHTVGLAIEDIGFDEDLNRFVDLEEAPMASVFKLYPWEWMLDDDFGRHAVEQLPTTMWVEPLWKTLLSNKAILAILWEMYPGHPNLLPAYVDDPHELTEYVRKPKLGREGANITIVGAGYETETGGVYGEEGYVYQLLDPLPQFDDMRPALGAWIVGDESAGLGIRETSGLVTDNGAAFVPHRIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIT3</accession>
    <name>A0A132PIT3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hisitidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852369.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04375"/>
    <dbReference type="EnsemblBacteria" id="KWX22097">
        <property type="protein sequence ID" value="KWX22097"/>
        <property type="gene ID" value="AFM11_21570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1662"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="156" mass="16617" checksum="66C8D11824878E5C" modified="2016-06-08" version="1">MDLQPYVEAVRHELAVAAAAGGADAEALAQRLTAPLESALRLALLEALSEAAEQITRELAPGSVEVRLRGRDPEFTVENAPPEATTSVAPEMDDDGGGTWRVTLRLPESLRTNVDAAARRDGVSVNAWLVRAVGSALRGPLQPPHSTDKTFSGWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIU6</accession>
    <name>A0A132PIU6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852062.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06160"/>
    <dbReference type="EnsemblBacteria" id="KWX22266">
        <property type="protein sequence ID" value="KWX22266"/>
        <property type="gene ID" value="AFM11_20745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1488"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="148" mass="15714" checksum="5555295343C8B7E4" modified="2016-06-08" version="1">MPGLLQRLSSVLGEVMSVVEEEDNALTVTVDGSVASVRVVAIAEDLEMVSLTQPLAWDLPLNNKIRDRVAAHASRTMLGTVVLVEKVVETPTDGATAKGAVRTGAAKKVADVMLRYNFPAAGLTDDALRTLILMVLATGADVRRDLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIW1</accession>
    <name>A0A132PIW1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_20920</name>
        <name evidence="5" type="ORF">AWC31_06340</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852124.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06340"/>
    <dbReference type="EnsemblBacteria" id="KWX22298">
        <property type="protein sequence ID" value="KWX22298"/>
        <property type="gene ID" value="AFM11_20920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09830">
        <property type="protein sequence ID" value="ORX09830"/>
        <property type="gene ID" value="AWC31_06340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1525"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="218"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX09830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="453" mass="48107" checksum="320EE82B424743E9" modified="2016-06-08" version="1">MIDAQQVVDIALDAAGPGAETVVLVTDRADASLRWAGNSMTTNGETVSRTTTVISIVRQGEKAHVGSVRSSEVDPAVIPELVAAARQAALAAPEARDAAPPLPADAGPADWDAPVPGTGSQVFSGIAGDLAKGFRGSDQLYGYARHVLETTFVATSSGLRRRYSQPTGSVEINAKRNGASAWAGVSTPDFVDVRVDSLLDDLSLRLGWAERTVELPAGRYETIMPPSTVADMMIYLAWTMDGRGAQEGRTALSAPGGTRVGEKLTDLGLTLYSDPYAQSLACQPFVAVPTSSERVSIFDNGMDIGRVDWIRDGVVNALAYPRAVAAEYGAPVAAPADNLLMTGGTAELADMIAGTERGLLLTTLWYIREVDPTVLLLTGLTRDGVYLIEDGEVTGAVNNFRFNESPLDLLRRATEAGISEVTLPREWGDWATRASMPTLRIPDFHMSSVSQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIX9</accession>
    <name>A0A132PIX9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_21030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06395"/>
    <dbReference type="EnsemblBacteria" id="KWX22318">
        <property type="protein sequence ID" value="KWX22318"/>
        <property type="gene ID" value="AFM11_21030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1551"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010846">
        <property type="entry name" value="DUF1460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07313">
        <property type="entry name" value="DUF1460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453061" evidence="2">
        <location>
            <begin position="41"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="156"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="544" mass="58504" checksum="D69163203B336131" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ68</accession>
    <name>A0A132PJ68_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21290</name>
        <name evidence="3" type="ORF">AWC31_06665</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852246.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06665"/>
    <dbReference type="EnsemblBacteria" id="KWX22353">
        <property type="protein sequence ID" value="KWX22353"/>
        <property type="gene ID" value="AFM11_21290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09883">
        <property type="protein sequence ID" value="ORX09883"/>
        <property type="gene ID" value="AWC31_06665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1604"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="56"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="289" mass="31458" checksum="49603A0B6BFE6DE0" modified="2016-06-08" version="1">MSNTVYRSPAGQNAIERSYREHLQRWTTPVRQRTVPTREGETFVLDCGPADAPPAVLLHGAGSNSAIWQADAPRWSLTHRLYMVDVIGEPGLSAPVRPDLNSDAHALWLDDVFDELRIDTAAIVGVSLGGWLATDYAIRRPGRVQRLALRAPGGIGRQRYGAVLAALVLAPFGDRGTRTALRIALGPGTVPDPVIDYMLLIQRNYRPRRDTLPIFSDEQLQAITAPLYVALGAGDRLLNSRDTATRLKRLQPSASVNLLAGTGHGMFDDADDIYTFLNEGSKSLGGNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJB3</accession>
    <name>A0A132PJB3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851882.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28515"/>
    <dbReference type="EnsemblBacteria" id="KWX22439">
        <property type="protein sequence ID" value="KWX22439"/>
        <property type="gene ID" value="AFM11_20000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1335"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="164" mass="18119" checksum="70510C964103B1CB" modified="2016-06-08" version="1">MAEVRVVGIRVEQPQNQPVLLLRESNGDRYLPIWIGQSEAAAIALEQQGVEPARPLTHDLIRDLIAALGHSLKEVRIVDLQEGTFYADLIFDRDIKVSARPSDSVAIALRVGVPIYVEESVLAEAGLLIPDENDEEAAGTVREDEVEKFKEFLDSVSPDDFKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJK1</accession>
    <name>A0A132PJK1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DtxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_22130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852554.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04890"/>
    <dbReference type="EnsemblBacteria" id="KWX22192">
        <property type="protein sequence ID" value="KWX22192"/>
        <property type="gene ID" value="AFM11_22130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1774"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="234" mass="25550" checksum="D01E837FF32E282C" modified="2016-06-08" version="1">MSPDGNHRDLSTVAQDYLKVIWTAQEWSREKVSTKLLAERIGVSASTASESIRKLADQGLVHHEKYGAVTLTDEGRRAALAMVRRHRLMETFLVQELGYGWDEVHDEAEILEHAVSDRMLDRIDAKLGHPTRDPHGDPIPATDGQVPTPPARQLSVCQDGEAGTVARISDADPEMLRYFDSVGISLDSRLRVLARRDFAGMISVAVESPTGSGDPDTTVDLGSPAAEAIWVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJZ1</accession>
    <name>A0A132PJZ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_19175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851640.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15245"/>
    <dbReference type="EnsemblBacteria" id="KWX22623">
        <property type="protein sequence ID" value="KWX22623"/>
        <property type="gene ID" value="AFM11_19175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1169"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="34683" checksum="DCF60B549A4CC81C" modified="2016-06-08" version="1">MRNFILSRLAAMVAILVALTAVMFVLQHISPLDPVKAQLGANSSAEAVAARRQALGLDQPLINQFWHYLTGAVQGDLGTSYRTRHSVSSDLGSFFPATLELALSGIALALVLAAFLAFGTTLKWPGSGVLRAVLFTGASAPMFLLGIVGLIVFYQQLGWVPANGRIGVANPPAGPTGMLTVDGLLAGRFDVVIDAAHHLILPAAVLAVGPAVAIGRVLRSSLLSDANSDYARTARAKGLSETRVMVGHVLRNCVGAALSMTGLQVGLMFAGVLVIEQVFGWPGIGQYIAQSIPVADFPAIAGVTLMLGVLYVVINTAVDLLQAAADPRIAITGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK46</accession>
    <name>A0A132PK46_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851800.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_14955"/>
    <dbReference type="EnsemblBacteria" id="KWX22720">
        <property type="protein sequence ID" value="KWX22720"/>
        <property type="gene ID" value="AFM11_18865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1108"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="202" mass="21785" checksum="8AAF5F328C99528D" modified="2016-06-08" version="1">MQLLLVRHALPLRSEPGQGSDPVLSEVGAEQAGRLPAALARFPISRVVSSPQRRAIQTADPVAAALGLSVEIDDRLAEYDRDMSHYVPIEDIAKENPEELARLVNGHLPSGVDEGAFKARINAAVADLVAAGDHDDTVAVFSHGGVINVLLHEILGTERLLSFHVDYASVTRLLSSRSGKLAVASVNGTEHVWDLLPRNVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKD3</accession>
    <name>A0A132PKD3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteasome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17745</name>
        <name evidence="3" type="ORF">AWC31_11865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851140.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11865"/>
    <dbReference type="EnsemblBacteria" id="KWX22791">
        <property type="protein sequence ID" value="KWX22791"/>
        <property type="gene ID" value="AFM11_17745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18691">
        <property type="protein sequence ID" value="ORX18691"/>
        <property type="gene ID" value="AWC31_11865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.904"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="341" mass="37473" checksum="A53F5DCBD3D9C5C1" modified="2016-06-08" version="1">MADSSNNPEQHYQPDQSGMYELEFPAPQLTSTDGRGPVLIHALEGFSDAGHAIRLAAEHLKNTLDTELVASFAIDELLDYRSRRPLMTFKTDHFTGYEEPELNLYALHDSVGTPFLLLAGLEPDLRWERFITAVRLLAEQLGVRQVIGLGTIPMAVPHTRPVTLTAHSNNKELIADHTPWVGEVQVPASVSNLLEFRMAQHGHEVVGFTVHVPHYLAQTAYPAAAEALLAEVSRTGSLQLPLAALSEAGAEVYSKINEQVEASAEVAQVVTALERQYDAFVAAQENRSLLARDEELPSGDELGAEFERFLAQQAGDKFKDDKYKDGHSEGFGDGFPHGDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKJ7</accession>
    <name>A0A132PKJ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_14915"/>
    <dbReference type="EnsemblBacteria" id="KWX22717">
        <property type="protein sequence ID" value="KWX22717"/>
        <property type="gene ID" value="AFM11_18825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1100"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="273" mass="28660" checksum="8AD98D452C637C97" modified="2016-06-08" version="1">MGSKLARTAMNAGHPVTVWNRSPERAAALVADGASAAPTPAEALDADVVVVCLFDHASVHEVLDPVAGKLAGRRVVNLTTTSPEGARELAAWASGLGADYLDGGIMATPEMIATPQSAILYSGSQALFDDYRELFETWGSAEYFGEDAGMASLYDLALLSGMYVMFAGFFHGAAMVAAAGVPAKEFAARAANWLATVVPVITEYAAVIDGGDYGVPGQQSLYFSDISDIVNASRDQGISTEVVDVVQRLIHRQIDAGHGNDGFARIFESIRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKV6</accession>
    <name>A0A132PKV6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_17910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851194.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11980"/>
    <dbReference type="EnsemblBacteria" id="KWX22817">
        <property type="protein sequence ID" value="KWX22817"/>
        <property type="gene ID" value="AFM11_17910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.937"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020287">
        <property type="entry name" value="Tail_sheath_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17482">
        <property type="entry name" value="Phage_sheath_1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_sheath_1" evidence="2">
        <location>
            <begin position="234"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_sheath_1C" evidence="3">
        <location>
            <begin position="396"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="513" mass="55706" checksum="64C972954DF101A4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKZ2</accession>
    <name>A0A132PKZ2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bipA</name>
        <name evidence="4" type="ORF">AFM11_16705</name>
        <name evidence="5" type="ORF">AWC31_01275</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850723.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01275"/>
    <dbReference type="EnsemblBacteria" id="KWX23011">
        <property type="protein sequence ID" value="KWX23011"/>
        <property type="gene ID" value="AFM11_16705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13194">
        <property type="protein sequence ID" value="ORX13194"/>
        <property type="gene ID" value="AWC31_01275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.692"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX13194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="633" mass="68427" checksum="9254F9ABE86C1799" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL01</accession>
    <name>A0A132PL01_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850746.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01335"/>
    <dbReference type="EnsemblBacteria" id="KWX23021">
        <property type="protein sequence ID" value="KWX23021"/>
        <property type="gene ID" value="AFM11_16765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.706"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="1">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="36885" checksum="A4EA88943F3266ED" modified="2016-06-08" version="1">MTRILAPLTALALVIALLTGCSSGDDGGRTKLVIAYQDNGIPALVKESGVLDGAPYDVEWAILAGPAANLSALYGKTIDVGHMGDTSLTIEQANAAQDWTEQTVPLKIVAGWRNGFDPRYTPLVTAVRANSGINSLADLRGHTWAYNFGGYNHAQYLVSLSRAKLTESDIKPVKFNDGNASAAAFNSGQVDVYSGGQAAILDSITKGDAKILLSERDTKIPALNVWTARTDVLADPAKDEALRDFFTRLSGFWTWYDDNPDTVKQTLKSTLKLSDARTEFEYQVRSGPFRKLDAALVAEEQAVADELHAAGVLKKPVAVAIEYDPRYNDAQKAQGPQAAAPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL77</accession>
    <name>A0A132PL77_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17245</name>
        <name evidence="4" type="ORF">AWC31_01810</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850917.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01810"/>
    <dbReference type="EnsemblBacteria" id="KWX23105">
        <property type="protein sequence ID" value="KWX23105"/>
        <property type="gene ID" value="AFM11_17245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13289">
        <property type="protein sequence ID" value="ORX13289"/>
        <property type="gene ID" value="AWC31_01810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.802"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX13289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="349" mass="37230" checksum="5140B23260C63D33" modified="2016-06-08" version="1">MRLSVLDLVPVRTDQTTADALTATTHLAQTADRLGYTRYWIAEHHNMPAVAATSPPVVIAHLAAHTDQLRLGSGGVMLPNHAPLAVAEQFALLEAAHPGRIDLGIGRAPGSDPVTSLALRGAAGRDDRDIEAFPQYLDDVRALMSARGVRVPLPRDLLRENYVLKATPVAVTEPRLWLLGSSMYSAHLAAAKGLPYVFAHHFSGHGTAEALAVYRDEFQPSDLAAEPVTFLTVNAVVAETSEEAKALLLPQLQMMGRLRTGQPLGALDLVEDAEATTMTPQAQAVVQAGLQRAVVGSPTEAADQVRALAEEFDVDEVMVNPVASARRGADPATATARDTTLELLAKELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL90</accession>
    <name>A0A132PL90_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_17285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850933.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23111">
        <property type="protein sequence ID" value="KWX23111"/>
        <property type="gene ID" value="AFM11_17285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.810"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453109" description="Probable membrane transporter protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="244" mass="24597" checksum="0B18580321F6710D" modified="2016-06-08" version="1">MQAADLVVVAAAVVAGAVNAAAGSGSLVTFPALVAAGLPPVGANMLNTVGLAPGMMLAAWTDRRVLRDIAGLVWLLPIGVLGAVCGAGLLRVAPPDLFHAAVPYLIGGAAVLVAAQPVLVKRLRRTGNGGWLYPCVFAVSVYGGFFSAAQGILLLAVVGLCLDTSVPEQNAIKNVMQGLVSLVAGIFFLVTSAIDWKTALILAAGSAAGTPLGIRLVRHISPNVFRIGVAAFGATAAVVFLLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL98</accession>
    <name>A0A132PL98_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850947.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01900"/>
    <dbReference type="EnsemblBacteria" id="KWX23118">
        <property type="protein sequence ID" value="KWX23118"/>
        <property type="gene ID" value="AFM11_17320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.817"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="609" mass="68049" checksum="7797C2EDB10242A1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLL2</accession>
    <name>A0A132PLL2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureG</name>
        <name evidence="6" type="ORF">AFM11_15250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850161.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15870"/>
    <dbReference type="EnsemblBacteria" id="KWX23183">
        <property type="protein sequence ID" value="KWX23183"/>
        <property type="gene ID" value="AFM11_15250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7163"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="204" mass="21710" checksum="DCE54E725F5390A5" modified="2016-06-08" version="1">MSVRIGIGGPVGSGKTRLVERLVPILSGNGIDVAVITNDLVTDEDAQRVRRSGVIDPARVLAVETGACPHTAIREDPSANLAAVFELERQYPGLDVVLIESGGDNLAATFTSDLVDYWIFVIDTAAGDDIPRKKGIGLLQADLLVVNKIDLAPMVGADLDRMRADCAVARPTKPTVFTDLRSGTGLDDVFTTVCRGAMLEPQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLL4</accession>
    <name>A0A132PLL4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_15570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850279.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16215"/>
    <dbReference type="EnsemblBacteria" id="KWX23240">
        <property type="protein sequence ID" value="KWX23240"/>
        <property type="gene ID" value="AFM11_15570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7231"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="193" mass="21255" checksum="FB2C7FD22681E4CD" modified="2016-06-08" version="1">MARTQQQRREETVARLLDASIDTIIDVGYAKASAAVIARRANVSDGALFRHFPTMGDFMAATGREVMRRQLELFTKRVTEIPAEQPALEAVLTILRDVTGNDTNTVMYELMVAARTDEKLKAALRDMLGEYATNIYETARTVPGSEQFPEDVFTAAVAILINTFDGAAIVRSVLPQPELEGPRIALLTALLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM33</accession>
    <name>A0A132PM33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine/betaine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_14040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849688.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09430"/>
    <dbReference type="EnsemblBacteria" id="KWX23410">
        <property type="protein sequence ID" value="KWX23410"/>
        <property type="gene ID" value="AFM11_14040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6912"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13560">
        <property type="entry name" value="PBP2_taurine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010068">
        <property type="entry name" value="Peri-bd_TauA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF38">
        <property type="entry name" value="PTHR30024:SF38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453416" evidence="2">
        <location>
            <begin position="22"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="33"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="36227" checksum="876DAE4299E7C1B3" modified="2016-06-08" version="1">MNLKALLATAAAAMLTLAGCAVDNSGNDSQKPTIRLGYQSFPSGDLIVKNNKWLEEALPDYNIKWTKFDSGADVNTAFIAKELDFGALGSSPVARGLSAPLNIPYKVAFVLDVAGDNEALVARNDSGINTIADLRGKRVATPFASTAHYSLLAALAQNGLSPSDVQLIDLQPQAILAAWDRGDIAAAYTWLPTLDQLRKTGKDLITSRQLAKDGKPTLDLGVVSDEFAAAHPDVVDTWREQEARALDVIKNDPAAAAKAIAAEIGLPPQDVEGQLKQGVYLTPAEVASEQWLGSEGAPGNISANLQSASQFLADQKQIPAAAPLPTFQDAIYTKGLPGAITKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM56</accession>
    <name>A0A132PM56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_15960</name>
        <name evidence="5" type="ORF">AWC31_16535</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850572.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16535"/>
    <dbReference type="EnsemblBacteria" id="KWX23383">
        <property type="protein sequence ID" value="KWX23383"/>
        <property type="gene ID" value="AFM11_15960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18163">
        <property type="protein sequence ID" value="ORX18163"/>
        <property type="gene ID" value="AWC31_16535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7317"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040846">
        <property type="entry name" value="ORF_12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18042">
        <property type="entry name" value="ORF_12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453398" evidence="1">
        <location>
            <begin position="23"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="ORF_12_N" evidence="3">
        <location>
            <begin position="33"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="164"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX18163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="435" mass="46823" checksum="6F3F19FE5CB607F6" modified="2016-06-08" version="1">MATIVAVAATLACGCSHSVAPAAEVSYGAHIDTKTPPGLRAKQTMDMLNSDWPIGPIGVRTLAAPEAVDEVGTKMDSIWWDRPFRVTSVDIGAGQATLHVLTSYNVAQDIELRTDDLGMVDRFEVNTVHPTIDKWSDIDEEIAKTGAKYSYQVSKVTDGKCETVAGTNTDLSLPLASIFKLYVLLAVSDAIKANTLSWDDKLTITKDGKALGSAGLDKLPPGAQITVRTAAQQMISASDNMATDLLIARMGTGAVERALVTAGHHDPASMTPFPTMHEVFSVGWGEPNLREQWKNASPEDRVRLFKQTNSRPYQPDPNRTHTPASNDGLEWFGSAADICRVHAALQKSAVGEAAPVKQILSALPGIDLDPAKWHYIGAKGGNLPGDLTFSWYAVDHTGQPWVVSFQLNWPQFRSPTAAGWLLSIAKRAFALAPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM57</accession>
    <name>A0A132PM57_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850911.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01795"/>
    <dbReference type="EnsemblBacteria" id="KWX23102">
        <property type="protein sequence ID" value="KWX23102"/>
        <property type="gene ID" value="AFM11_17230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.799"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="243" mass="27029" checksum="A4EDB5E65AF66B6F" modified="2016-06-08" version="1">MKIYATYNIKGGVGKTSAAVNLAHLSGREGNRTLLWDLDPQGAATYLFRIRPKVKGGSKALVRGTRSLDEAIKATDFDLLDLVPADFTYRNMDVQLDSAKRPTRRIRQLLAPLEDEYDVVFLDCPPSISLVSENVLHAVDTLLVPMIPATLSVRTFDQLVDFVGDFDGRQPAVKAFFSMVDRRKKLHRDVVTQLSQERQGILGADIPALSVIEQMAEKRAPVTAFAPQSSAAQQYEALWNEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMJ8</accession>
    <name>A0A132PMJ8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="6" type="ORF">AFM11_14990</name>
        <name evidence="7" type="ORF">AWC31_17915</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850004.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17915"/>
    <dbReference type="EnsemblBacteria" id="KWX23561">
        <property type="protein sequence ID" value="KWX23561"/>
        <property type="gene ID" value="AFM11_14990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17204">
        <property type="protein sequence ID" value="ORX17204"/>
        <property type="gene ID" value="AWC31_17915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7108"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX17204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="86" mass="9685" checksum="15B40CF666E3E83B" modified="2016-06-08" version="1">MAKTNKRRPAPEKPVKTRKCVFCSKKGKGQVIDYKDTALLRTYISERGKIRARRVTGNCVQHQRDVAVAVKNAREVALLPFGSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMT0</accession>
    <name>A0A132PMT0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_12520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848937.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02780"/>
    <dbReference type="EnsemblBacteria" id="KWX23625">
        <property type="protein sequence ID" value="KWX23625"/>
        <property type="gene ID" value="AFM11_12520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6594"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004707">
        <property type="entry name" value="MmpL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00833">
        <property type="entry name" value="actII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="775"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="800"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="875"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="909"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="235"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="963" mass="105833" checksum="26C3D22199E17C98" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMU3</accession>
    <name>A0A132PMU3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="6">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="6">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">menA</name>
        <name evidence="7" type="ORF">AFM11_12710</name>
        <name evidence="8" type="ORF">AWC31_03030</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849039.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03030"/>
    <dbReference type="EnsemblBacteria" id="KWX23658">
        <property type="protein sequence ID" value="KWX23658"/>
        <property type="gene ID" value="AFM11_12710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11120">
        <property type="protein sequence ID" value="ORX11120"/>
        <property type="gene ID" value="AWC31_03030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6632"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX11120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="292" mass="29885" checksum="9827384A06BD1E69" modified="2016-06-08" version="1">MASFAQWIEGARPRTLPNAISPVIAGTGAAAWLGAAVWWKALLALVVALALIVGVNYANDYSDGIRGTDDVRSGPLRLVGSRLASPRAVLTAALLSLGVGAVAGLVLAAVSAPWLIVVGAVCIAGAWLYTGGKKPYGYLGLGEVAVFIFFGLVAVLGTQYTQALRIDWVGVVAAVVMGSLSSAVLVANNLRDIPTDAQSGKITLAVRLGDARTRVLFQVLMAIAFVLTLVLIAATPWCAVGLLALPLALRAIRPVRTGLGGAALIPVLRDTGLTMLVWAVAVGVALGVAGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMV6</accession>
    <name>A0A132PMV6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15465</name>
        <name evidence="3" type="ORF">AWC31_16310</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850554.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16310"/>
    <dbReference type="EnsemblBacteria" id="KWX23372">
        <property type="protein sequence ID" value="KWX23372"/>
        <property type="gene ID" value="AFM11_15465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18156">
        <property type="protein sequence ID" value="ORX18156"/>
        <property type="gene ID" value="AWC31_16310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7208"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="130" mass="12787" checksum="10408F8ED0B0B135" modified="2016-06-08" version="1">MTSQPDPAVGASSAAAAASCAVEERRIGEISVVSVAGTVDMLTAPQLEEAIGSAAKSSPAAVVVDLSEVDFLASAGMGVLVAAHGDLSPEVKVAVVADGPATSRPLKLVGIAEVVDLFATLDEALSSLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMY1</accession>
    <name>A0A132PMY1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0065 (bug) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849673.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09480"/>
    <dbReference type="EnsemblBacteria" id="KWX23402">
        <property type="protein sequence ID" value="KWX23402"/>
        <property type="gene ID" value="AFM11_13990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6901"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005064">
        <property type="entry name" value="BUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042100">
        <property type="entry name" value="Bug_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42928">
        <property type="entry name" value="PTHR42928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03401">
        <property type="entry name" value="TctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017082">
        <property type="entry name" value="YflP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453470" evidence="2">
        <location>
            <begin position="36"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="341" mass="35329" checksum="05735D600C870820" modified="2016-06-08" version="1">MAISTARSRRGRTRTILAAAAAAGLALTACGGVETTTGGGGSDAGWPSGSVEMYVGASAGGSSDLISRAVSKGLSDDLGASFPVINREGANGALAAAEVAKAPADGSVIAIQNASLFTITPLAVSPDEVTNLDDFDVVYGVSRDDYVLVTNPASGFKTLEDIKNANRLVKYGTTGVGTGAQLSAALLFKTSGVDSQAVPFDGGAPALAAVLGNQVDVASIQVGEAIENIQSGKLTPLAVFGPDRIDYLPEVPTAKEQGLDVEVTQYRFMTVPKGTPQEVKDKLIEGLKATYATDEYKKFNEQNSLTPMEISGDEVTAQLNKDKQRYADLVAQYGINLRDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN66</accession>
    <name>A0A132PN66_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849857.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18295"/>
    <dbReference type="EnsemblBacteria" id="KWX23492">
        <property type="protein sequence ID" value="KWX23492"/>
        <property type="gene ID" value="AFM11_14530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7014"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="163" mass="18765" checksum="F37EB508341996FC" modified="2016-06-08" version="1">MTDSGEYPLTPRQQRAWLNFMRVYHRLEYEVNRHLRTECGLSLYDYTVLSTLSRAPDRRLQLTTLATVIGWERSRVSHHLMRMARRGLVERTTCDTDGRGTVVVLTDEGWDRLAGAAPVHAEWVHRAFFADLDPEHEDALADILDAVHESLLREGTLPRPDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNB8</accession>
    <name>A0A132PNB8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GlcNAc-PI de-N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849525.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23838">
        <property type="protein sequence ID" value="KWX23838"/>
        <property type="gene ID" value="AFM11_13850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6866"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="241" mass="26450" checksum="BC77545C68E57207" modified="2016-06-08" version="1">MSEVEPKRLLVVGAHSADFVWRSAGAIAKHTAAGGEARVVALSYGERGESGELWKEPGQTVDNVKRHRHAEATEAAETVGATFECFDLGDYPLEVGPDAIDRLAELMRDFAPHVVLTHPDKDPFNPDHPVANVAVSKARLLTAGAVVEAGFRTAPPSEFLVFEPHQPELCGFTPSVFVDITDVFELKRKAMAAMRAQSYLQQYYAERADHRGNHARKVTGRKQIRQAEAFQRLVPNVVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PND9</accession>
    <name>A0A132PND9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849054.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03065"/>
    <dbReference type="EnsemblBacteria" id="KWX23859">
        <property type="protein sequence ID" value="KWX23859"/>
        <property type="gene ID" value="AFM11_12745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6640"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="119" mass="12454" checksum="858BB9D59643D90B" modified="2016-06-08" version="1">MRCLIVDDSANFRTAASAMLGRGGVDVVGAASNSDEALRMCRELQPDVVLVDVALGPESGFDLADELDGSALPTPPAVILISTYAEQDLHEMIACSPAVGFVPKFALSVAAIEYLLARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNF0</accession>
    <name>A0A132PNF0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850028.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17790"/>
    <dbReference type="EnsemblBacteria" id="KWX23572">
        <property type="protein sequence ID" value="KWX23572"/>
        <property type="gene ID" value="AFM11_15050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7121"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="55"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="344" mass="37477" checksum="E7D899BE476E79BE" modified="2016-06-08" version="1">MTLPGIIAVEEHVATDAFLNAAHRLEVAPADRRELELMRTVERQERFRTALTDIDARIAEMDAAGQAMAVLSINPPGVQPYSAADAVPLARAVNDDLAAILQRHPYRFGALGTITPQAVDAATQEIERIMGPLGLNGVMINSHTHGRYLDEPEFEPILAAAQAYGAPIYLHPRFPSTLTPYDAYGLQGAIWGYQAEAGLHAMRLIMSGAFDKYPDLTIVLGHLGEGIPYWLRRIDNRHAFAAQVSGSAGRMPALELTPSEYFRRNFVLTTSGIDDPAVLDLALDAVGDDNIMFAVDTPYEDTAAAVRFLRDAPLTDTQRTNIAYRTAGRVFGLECSDPSDVSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP42</accession>
    <name>A0A132PP42_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_11365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848193.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30530"/>
    <dbReference type="EnsemblBacteria" id="KWX23967">
        <property type="protein sequence ID" value="KWX23967"/>
        <property type="gene ID" value="AFM11_11365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6350"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="503" mass="51957" checksum="3E7B0B4813BC3A9F" modified="2016-06-08" version="1">MTENQLAADPPVVPAGGGTSQSNLTGNMGVGSLMLTVLAFSAPIAAVAGFIPFSIMFGGEGATLVFAVATISMLLFAVGYVTMTKSLPKPGSFYAFISAGIGKATGLGAAFMAVVSYLLMLSGCFVFTGLTVTELVSSMGGPETPWWLWAIGCWVIVSILCYFHIEVSAKILSVAMVLEVAIVMVFNVAVLLRGGGPDGYSATPLNPASLSHGDFGIALLFAIMIFIGFEATALFRDEVRDPDRTIPRATYGAVLFVGALYTVSCYLLTTAYGANAVQAATDDPKMMFPGAIGAFAAPVFTQLTLAFIITSEMAAAISVHNVTARYIYNLGVDKALPAVFAQVHPRHGSPARAAVAVAVVVALLVLPLGLANQAGVGLDAQLFGLGTVGVLALMTLVSIAVIVWFSRRGIPPGANWFKCFGAPALAVAALGPTIVLAVLHFDLVVGGAPGQNLGLLLVLGASLVIGAGLALYFRSAKPQVFARLGRADTGEVEKADAVVPTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP52</accession>
    <name>A0A132PP52_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848639.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09795"/>
    <dbReference type="EnsemblBacteria" id="KWX24110">
        <property type="protein sequence ID" value="KWX24110"/>
        <property type="gene ID" value="AFM11_12180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6515"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="207" mass="23208" checksum="21DC7BF7D7610FE0" modified="2016-06-08" version="1">MTLAPDVRVARDARREGVPPSQQSSGRSSGQRSQAPRPQGQRAQNARQRPAQGAQQQPPRQPPFDDRPVEYWPTAAIRAALETDDMTVWQRIVAAVKRDPYGRTARQVEEVLETARPYGVSKALSEVLVRTREHLEATERAEVARQIQAMLRRSKLEPQEFASRIGVSNESFATYLEGKTSPPASLLLRMQRLSDRFAKIAAQRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP94</accession>
    <name>A0A132PP94_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_12205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848648.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09770"/>
    <dbReference type="EnsemblBacteria" id="KWX24113">
        <property type="protein sequence ID" value="KWX24113"/>
        <property type="gene ID" value="AFM11_12205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6520"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453173" evidence="5">
        <location>
            <begin position="31"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="105"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="191"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="335" mass="35938" checksum="C753C6DF514B9B1D" modified="2016-06-08" version="1">MPNSAKRRLITALMAAGLVGGLVTAPSALAEPVPPPPPPAPIDPAVAPAPVVPPPTDPLAPVTAADPAVPEPVNNYGAPAVPIEGTPAGQNPEPFTGQPPFLPPSFNPVNGSMVGVAKPIYINFQRPIADRQMAQDAIRITSNPPVPGRFYWVTDTQLRWRPQDFWPANTVVNIDAAGTKSSFRVGDYLVATVDDSTHQMEIMRNGKLEKTFPVSMGKSDGKHETRNGTYYVLEKFPDIVMDSSTYGVPVDSAEGYKLKVQDAVRIDNSGIFVHSAPWSVGDQGKRNVSHGCINLSPANAQWFYDQFGSGDPVVIKNSKGALYDLPDGASDWQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPA6</accession>
    <name>A0A132PPA6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848771.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09580"/>
    <dbReference type="EnsemblBacteria" id="KWX24145">
        <property type="protein sequence ID" value="KWX24145"/>
        <property type="gene ID" value="AFM11_12400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6559"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="21719" checksum="C7F447E99C09834A" modified="2016-06-08" version="1">MAGRPREFDRDAALRTMQELFWRHGFEGVSMADLVAATGLASARLYAAFGSKEQMFREAVELYMQTEGGFADRTIAEEPTLADALRRMLRDAVDVYAKPHPRGCMVVAAATNCTPGHEEIREWLEKHRHERAQSITRAVRAAKKSGELRPDADVQQLGDYFATVLNGLSVQARDGVSPRRLRAVIEPAIAVLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPF2</accession>
    <name>A0A132PPF2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847107.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05790"/>
    <dbReference type="EnsemblBacteria" id="KWX24211">
        <property type="protein sequence ID" value="KWX24211"/>
        <property type="gene ID" value="AFM11_09435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5924"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAP_DH_C" evidence="1">
        <location>
            <begin position="146"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="350" mass="37173" checksum="5B7A2CD555DC943D" modified="2016-06-08" version="1">MTAGQPPLRVIQWTTGNIGRRSLHAIIGRDDMELVGVYAHGSDKVGVDAAELAGWPEPTGVLATNSVDELLELKPDACCYNPLWPDVDELTRLLSAGVNVCSSAAWITGGKQTPEDLQRIRKACETGNSTIFGSGAHPGMTNMVGMVLSGSCERVDEIRITESVDCSTYESAGTQTAMGFSQDPETPGLAESVRRESEVFAESAAMMADAVGATLDRMTFDVTFTAATGDSDLGFMQIPKGTVAGVFGYHRGWVGDKNVVSVGFNWTMGDHVTPPKPLEHGHVIQVFGLPNMRTVLHCLPPKDWTEPGFMGLGMIYTALPVTNAVPAVVAAPPGIVTLKDLPPITGRFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPY2</accession>
    <name>A0A132PPY2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_10605</name>
        <name evidence="10" type="ORF">AWC31_19120</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX16955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847709.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19120"/>
    <dbReference type="EnsemblBacteria" id="KWX24406">
        <property type="protein sequence ID" value="KWX24406"/>
        <property type="gene ID" value="AFM11_10605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16955">
        <property type="protein sequence ID" value="ORX16955"/>
        <property type="gene ID" value="AWC31_19120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6161"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX16955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="391" mass="43141" checksum="3F497C09D0912B8F" modified="2016-06-08" version="1">MQLTFDSDVEEFRAEFAAFLDANLPSEAQTLERPRSVSHMPQWARDWQRLLFDNGWLLPAQPPEFGGRNASVVQTFVHLDELCRRRIYHSFNPQGVNIIAASLLTFGSDEQKRRWAVPVLRGEQTASLGMSEPSAGSDLASLRTRAVLDGDEFVVNGQKVWTSGAHDADFLLTFVRTDPDAPKHKGISALIIPTDTPGVVCRPFADMTGQENLDFNEVFFTDARVPAENLVGPLNGGWGVANGSLGHERTMMWLGFADRIDNMLADFEPRTELERDQYATTIMDYQALRAMGSAALAKASRGEADTASVSVLKLFGSEAERNAFENALTAAGPDGLIHPSTTGPYEHMNLDHYFASWFERYARSFGGTIAGGTSEIQRNIIATQVLGLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQG6</accession>
    <name>A0A132PQG6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24545">
        <property type="protein sequence ID" value="KWX24545"/>
        <property type="gene ID" value="AFM11_07615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5372"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="43" mass="5233" checksum="049C70EAFF346A47" modified="2016-06-08" version="1">MVDQKERNRKKALIVLQVVIYGYLLTVFLIQLYMSFARGWWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQJ3</accession>
    <name>A0A132PQJ3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_07890</name>
        <name evidence="7" type="ORF">AWC31_24490</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000014">
        <property type="protein sequence ID" value="ORX15188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036433691.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24490"/>
    <dbReference type="EnsemblBacteria" id="KWX24593">
        <property type="protein sequence ID" value="KWX24593"/>
        <property type="gene ID" value="AFM11_07890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15188">
        <property type="protein sequence ID" value="ORX15188"/>
        <property type="gene ID" value="AWC31_24490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5428"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX15188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="120" mass="12814" checksum="5015209EFA9D9110" modified="2016-06-08" version="1">MSTKPEIEFPDGPAPTELVITDLVVGDGPEAVPGGTVEVHYVGVEYDTGEEFDSSWNRGESIEFPLRGLIQGWQDGIPGMRVGGRRKLVIPPAQAYGPAGSGHRLSGKTLIFVIDLLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQM4</accession>
    <name>A0A132PQM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_07780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846118.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24574">
        <property type="protein sequence ID" value="KWX24574"/>
        <property type="gene ID" value="AFM11_07780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5407"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="486" mass="52076" checksum="A6FE1E54D20A454F" modified="2016-06-08" version="1">MATDSASIESKSIDWIPLDERRGKPSMLFPLWFMSNANLTTLATGMVGAALGASFLTSLVAIVLGAAVGTVFTAFHSAQGPQLGLPQMIQSRAQFGYRGVVVICAVVIFSIVGFNIFNQILAGDVLTMTTGVDARNLWFVLITALALALAIYGYHWIHRVQNWLTWLFLATFGVFTVVALTTLHLPHGQFGFAGFSWPAFLVQFAAAAAYALGWAPYVSDYSRYLPPQTSPGKALFYTYGGVFVGSSWLMVLGAFVAALFADVSPLEAVKQAADAVLPGAGLWLLVAALPGLVTVITVNIYASSIELITIIDSFRAVSPTRRLRVGACVVIGLAGLSGAVLSTGEFLDNFSSFLVILLYLLVPWTSVNLVDYYFVRRGRYAIREIFVPRGGVYGTWGWRGLAAYAIGIIAMIPFVVTVWYTGPVAKALGDVDVALFVGLFASAVAYLLMARSLDLAAEQAKAQSDAHEHGFQAVSFASARTGDQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQN3</accession>
    <name>A0A132PQN3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846293.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24633">
        <property type="protein sequence ID" value="KWX24633"/>
        <property type="gene ID" value="AFM11_08115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5474"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="335" mass="37027" checksum="F27102CF401EA707" modified="2016-06-08" version="1">MSDNGTPSTPALTRGLVLQAPITADDLPPVGPPLRTVVVNVDLGRRRLRPEEWALLADYMRPHPHLELKVRFTNKKKPWDLEFLAPFGHLTKLWIEGTTPESMDGLRHVPRLRSLVLLDEDKRRSLEVLSQLTDLRSLVIAGHSRELDVLGTLPNLRTVSLRGVKRDNLEFLGDAPQLASLGLDYGRIGDISALPALPNLKILGIGYTKPTDLTPISGCTGLVRLSLDHMPLSTFPDLSALTELIAVEAIELKGLENLSPLATAPNLRYLVVDSKTLHPDAFAVLANHPTLEYLDAGLKNDTLSHQPNQALDLPRDVDHHYDKLLSEMFARIVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQT0</accession>
    <name>A0A132PQT0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846461.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24690">
        <property type="protein sequence ID" value="KWX24690"/>
        <property type="gene ID" value="AFM11_08455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5539"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453212" evidence="2">
        <location>
            <begin position="31"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="146" mass="14586" checksum="E08E7C026B97A929" modified="2016-06-08" version="1">MKIVSVLGSVLGTSAAGFAVALAGAGAASAAPDVVGQPYADAASAIEDAGGTPRVAVTVGGRLPKDECIVTNAWDTRPLVPMTDDVYWEHTEDVVQLSLNCAGDHATAVNPGASIASPLGREAKAAADEAAAAEEDELAEVSTPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR29</accession>
    <name>A0A132PR29_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13325"/>
    <dbReference type="EnsemblBacteria" id="KWX24791">
        <property type="protein sequence ID" value="KWX24791"/>
        <property type="gene ID" value="AFM11_09045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5659"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="14"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="395" mass="42322" checksum="C35BE286934EDED4" modified="2016-06-08" version="1">MVSKVENSVAAGPFTPMALGPLTLKNRFVKAATFEGVMPLGQVTDALVDFHVEVAKGGAAMTTVAYCAISPGGRVHRDTIVLDAERARALRRLTDAVHREGALACAQIGHAGLVANTLSNRTPSLAPSTRVSAPAMGLVRAATPEQLEKVVGQFGIAARNAVEAGFDAIEIHMGHGYLLSSFFSPNLNKRTDAYGGTTARRAELARRVAEEVRTAVGESVAVTAKFNMDDGVRGGFWLTDSLSTAQLLQADGHLDALQLTGGSSLLNPMYYFRGPVPLDEFIASQPAVVGLGLRVLGRRLFREYPFEEAFFLPLARQFREALTMPLMLLGGVNALATARDAVADGFEFVVMARALLRDPQLVNRFRGREATSGLCVHCMKCMPTVYSGTRCVVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR68</accession>
    <name>A0A132PR68_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846898.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21985"/>
    <dbReference type="EnsemblBacteria" id="KWX24831">
        <property type="protein sequence ID" value="KWX24831"/>
        <property type="gene ID" value="AFM11_07485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5345"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="139"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="27438" checksum="34E039B7677CA506" modified="2016-06-08" version="1">MVTRQTAPLGAPTWIDLTTSDVERAKRFYGAVFGWTFETGGEEYGGYVSAFLDGRVVAGIMHNEPQWNSPDFWTTYLHTADAEATVAAATAAGGSNCGGVMDIPAKGRMAMITDPAGAFFGVWQTAGHQGSEAFNEHGAPLYHQLTTRDYAGSLDFYRTVFGWTTKTVSDTDEFRYSTAAFDGEELVGVMDGSVYLPEGVPSTWTCFMGAEDVDKTIELIVENGGSVARAAEDTPYGRLAAVADPTGAGFNLSSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRI7</accession>
    <name>A0A132PRI7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="10" type="ORF">AFM11_05785</name>
        <name evidence="11" type="ORF">AWC31_11645</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000002">
        <property type="protein sequence ID" value="ORX19248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845097.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11645"/>
    <dbReference type="EnsemblBacteria" id="KWX24946">
        <property type="protein sequence ID" value="KWX24946"/>
        <property type="gene ID" value="AFM11_05785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19248">
        <property type="protein sequence ID" value="ORX19248"/>
        <property type="gene ID" value="AWC31_11645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4348"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="314"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX19248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="399" mass="41939" checksum="1808CF4AC5F09FD8" modified="2016-06-08" version="1">MLRWTTAGESHGRALVAMLEGMVAGVPITSDEIGAQLKRRRLGYGRGARMKFEQDQVTMLAGVRHGRTLGGPIAIEIGNTEWPKWETVMAPDPVDEAELDVARNAPLTRPRPGHADYAGMLKYGFDDARPVLERASARETAARVAAGTVARAFLREALGVEVVSHVISIGASEPYDGPPPQYSDLAAIDDSPVRAFDKDAEDSMIAEIEAAKKDGDTLGGVVEVVVDGLPVGLGSFTSGDNRLDSQLAGAVMGIQAIKGVEIGDGFETARRRGSVAHDEMYPGPDGVLRSTNRAGGLEGGMTNGQPLRVRAAMKPISTVPRALATVDMATGDEAVAIHQRSDVCAVPAAGVVVETMVALVLARAALEKFGGDSLAETRANVDAYLRAVAEREPAAQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRN1</accession>
    <name>A0A132PRN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25001">
        <property type="protein sequence ID" value="KWX25001"/>
        <property type="gene ID" value="AFM11_06100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4412"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="80" mass="8119" checksum="7D41724F83ED07CF" modified="2016-06-08" version="1">MRYMAFVAAVIVVLTLIAMTTGRAPAVLALICALVTAGLLRIATPGELFGGLSNAGVITIAAMLVIAKGVVNCSVLCEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS43</accession>
    <name>A0A132PS43_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_07110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845629.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17605"/>
    <dbReference type="EnsemblBacteria" id="KWX25178">
        <property type="protein sequence ID" value="KWX25178"/>
        <property type="gene ID" value="AFM11_07110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4620"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="31"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="283" mass="31040" checksum="6C4059F8AC437EED" modified="2016-06-08" version="1">MTEPPQVAEETIEELAGVHRDINAAEGEVLLETHDLTVKFGGLVALDAVTFNIRRGEILGLIGPNGAGKTTCFNAITGVYRPSSGSVSFDGAPLSRIKRHQITRRGIARTFQNIRLFGEMTALENVMVGTDARHRTSVPGALIRSPRHRREEKSAIERSAALLHFVGIAHRGEEKAKNLPYGDQRRLEIARALATEPKLLCLDEPAAGFNPSEKAALIDLIRKIRDDGYTVLLIEHDMRLVMGVTDRIVVLEFGRKIADGLPSQIREDPKVIAAYLGVPDDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSM4</accession>
    <name>A0A132PSM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844024.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21700"/>
    <dbReference type="EnsemblBacteria" id="KWX25346">
        <property type="protein sequence ID" value="KWX25346"/>
        <property type="gene ID" value="AFM11_03450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2564"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024399">
        <property type="entry name" value="DUF2628"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10947">
        <property type="entry name" value="DUF2628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="135" mass="15041" checksum="8F468114849DA352" modified="2016-06-08" version="1">MAEHSPVDHLSTSWRRRFDFFDTYGLPNSTPQSKAAYRALPFGTKLRLTSNVLAFLFGPIYFFVKGMWRKGLTLLAVAVSVAVAMVFLNVPDSIGRAVGIGVAALAMSTANYAYYLHIVENSQSWNPFEGFGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSY8</accession>
    <name>A0A132PSY8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="11" type="ORF">AFM11_04170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844402.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20985"/>
    <dbReference type="EnsemblBacteria" id="KWX25459">
        <property type="protein sequence ID" value="KWX25459"/>
        <property type="gene ID" value="AFM11_04170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2711"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="656"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="835"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX25459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1210" mass="130438" checksum="A406AFB41B4CDB3F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT32</accession>
    <name>A0A132PT32_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844058.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21635"/>
    <dbReference type="EnsemblBacteria" id="KWX25357">
        <property type="protein sequence ID" value="KWX25357"/>
        <property type="gene ID" value="AFM11_03515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2577"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="249" mass="26802" checksum="68862411D04150E7" modified="2016-06-08" version="1">MTRQKILITGASSGLGAGMARQFAAKGRDLALCARRTDRLDELKAELADRHPYIKIAVAALDVNDHEAVPRVFGEMSEELGGIDRVIVNAGIGKGWPLGEGKPWANKATLETNLIAGLVQIESALEMFKKSGSGHLVLISSVLGNTGVPGGKAAYCASKAGMTSLGESLRAEYDKGPIRVTVIEPGYIESEMTARANSTMLMVDNETGVRAMVEAIEKEKGRAVVPRWPWAPLTQVMRLLPPKYTKRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTA3</accession>
    <name>A0A132PTA3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="11" type="ORF">AFM11_04805</name>
        <name evidence="12" type="ORF">AWC31_20340</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844633.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20340"/>
    <dbReference type="EnsemblBacteria" id="KWX25561">
        <property type="protein sequence ID" value="KWX25561"/>
        <property type="gene ID" value="AFM11_04805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16406">
        <property type="protein sequence ID" value="ORX16406"/>
        <property type="gene ID" value="AWC31_20340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2842"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="82"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX25561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX16406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="164" mass="18029" checksum="44FCB335A27B9364" modified="2016-06-08" version="1">MTDTQVTWLTQEAFDRLKAELDQLIANRPVIAAEINDRREEGDLRENGGYHAAREEQGQQEARIRQLQELLNNAKVGEAPKQSGVALPGSVVKVYYDDDKSDTETFLIATRQEGISDGKLEVYSPNSPLGGALIDAKVGESRTYTVPNGNTVKVTLVSAEPYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTG7</accession>
    <name>A0A132PTG7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844744.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20130"/>
    <dbReference type="EnsemblBacteria" id="KWX25613">
        <property type="protein sequence ID" value="KWX25613"/>
        <property type="gene ID" value="AFM11_05110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2903"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="564" mass="58605" checksum="06D387F9F95F2CCC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTJ3</accession>
    <name>A0A132PTJ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844546.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25517">
        <property type="protein sequence ID" value="KWX25517"/>
        <property type="gene ID" value="AFM11_04560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2791"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453622" evidence="2">
        <location>
            <begin position="23"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="467" mass="45969" checksum="F0269B34B9B380D3" modified="2016-06-08" version="1">MQLAVRSYLATGVAVAGVGVLAASPVAPPMPDLKVQAAHSSAAVELSALANPIAGYADAFSLAFQNAVALGQRVADNPAPILSQIVRNQLTSAAAIGAFVDAFGGSLSEGYAEVPAHLKVAAQQFADGDVTAALTTVQNALLGPVVQAVFDTLFLNPEVWEGFQNALRQPIANTLAIVDLLQPANIINLLGPLLAPVQVITDVVNVVGGAGDNIFAGIKDGDLEQVANAVLNFGPDLTNAILNGNSMGGGFAAGLLGPNGIVAGLITIGEIVADAITPAAAKSALAGASLLKTEAASTTVTLDVAPQAIEAPKAQEGTAVEQVSSTETAGESTTKETSAEASAPQAPAETPAEAPAQETAAEPAAPEEAAAEAPAEDAVKESPKAVPGKTGTDTSTKKANPLKDVGDGIRGALKNVGKGFKDAVSGASGKTAKPAKPAKAESTNSGGASGSEGGSSSAGGSESGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTQ9</accession>
    <name>A0A132PTQ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842044.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33150"/>
    <dbReference type="EnsemblBacteria" id="KWX25731">
        <property type="protein sequence ID" value="KWX25731"/>
        <property type="gene ID" value="AFM11_00045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.9"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021417">
        <property type="entry name" value="DUF3060"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11259">
        <property type="entry name" value="DUF3060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453288" evidence="1">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="136" mass="13619" checksum="984C2D02C520D1C5" modified="2016-06-08" version="1">MRAHMTKILGTAAAALAVFGLAACGSESQDTTSPSATAGSSGLNVEVGNTINYMSVGTTADIDCADGKSLTVGGANNTLTVKGTCANVNIGGSDNKINFEKIDKDLTVVGLNNTITYRDGDPKVTNTGSGNSVSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTV2</accession>
    <name>A0A132PTV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844773.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25627">
        <property type="protein sequence ID" value="KWX25627"/>
        <property type="gene ID" value="AFM11_05210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2924"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="164" mass="17881" checksum="7ABCA454462DEEFC" modified="2016-06-08" version="1">MTEIESADAIDEMVRAAQERSNVAYRELKELRDRAHTDEEEEAAELKAAESGYYLALAQAHSLGHSWMADFSRGAQKETLERSHLAVTIKQWQVDMLRVEVQTQRAKVAERAARAVTESNLKAANESARAARWTAYATIVLAVATVVLIVATLIAAKIASGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTX4</accession>
    <name>A0A132PTX4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844507.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25502">
        <property type="protein sequence ID" value="KWX25502"/>
        <property type="gene ID" value="AFM11_04465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2771"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="525" mass="57830" checksum="FF3561B8C504E8F2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU34</accession>
    <name>A0A132PU34_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844635.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20335"/>
    <dbReference type="EnsemblBacteria" id="KWX25562">
        <property type="protein sequence ID" value="KWX25562"/>
        <property type="gene ID" value="AFM11_04810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2843"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025443">
        <property type="entry name" value="DUF4307"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14155">
        <property type="entry name" value="DUF4307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="140" mass="15128" checksum="49684B4DD2C4EC6C" modified="2016-06-08" version="1">MIERPAARYGSQQLPRRTRRWILVAVAALVVVAGVVVAVIAFQRFGSGDVKGELTAYELIDDETVQVTIGVTRPDPSRPVVCIVRARSIDGGETGRREVLVAPSDQRVVQVTTQVKSTRKPVVGDIYGCGIDVPSYLVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU39</accession>
    <name>A0A132PU39_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842202.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33475"/>
    <dbReference type="EnsemblBacteria" id="KWX25784">
        <property type="protein sequence ID" value="KWX25784"/>
        <property type="gene ID" value="AFM11_00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="24620" checksum="674FE8E8FEE4A940" modified="2016-06-08" version="1">MRQPDPNRLGLLTTLALTFVTGIVDAVGYLGLDRVFTGNMTGNIVILGMGVAGADDLPVLGPAIALAGFTAGALAAGLTVRRRSAPGWDTRITLLLTIGAAVLLGLTVAVALGGDNPGTTGQVVIATAIATVMGVQAMVARALAVKDMTTVVVTSTLTSLAGETWTGGGRAAVFNRRIAAIVVIFLGAVAGAVLLRLHMAVPLALATALTGAVVIAGHLRLHERVSHAPETDVSRRAVLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU68</accession>
    <name>A0A132PU68_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fusA</name>
        <name evidence="8" type="ORF">AFM11_00080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842054.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33185"/>
    <dbReference type="EnsemblBacteria" id="KWX25737">
        <property type="protein sequence ID" value="KWX25737"/>
        <property type="gene ID" value="AFM11_00080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.16"/>
    <dbReference type="Proteomes" id="UP000070612">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
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    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="10"/>
            <end position="286"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="700" mass="77217" checksum="5F2E67641E3A4FFA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU88</accession>
    <name>A0A132PU88_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="KWX25834">
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        <property type="gene ID" value="AFM11_00625"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="33204" checksum="82196FAEBA7CCBFC" modified="2016-06-08" version="1">MQTIPAAMSTAATLDVIDVRGLTFTYPKAAEPAVRGMDFTVGRGEIFGFLGPSGAGKSTTQKLLIGLLRGHGGQATVWGRSPLEWGPDYYQRVGVSFELPNHYHKLTGLENLRFFASLYAGETAEPMELLDAVGLSDAANVRVGKYSKGMQMRLTFARSLINNPELLFLDEPTSGLDPVNARKVKDIVLDLKARGRTIFLTTHDMSTADELCDRVAFVVDGRIVALDSPNELKIARSQRRVRVQYRVPETGLTTAEFEMDGLADDPEFHRILRNHHVETIHSREASLDDVFVEVTGRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUG8</accession>
    <name>A0A132PUG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-oxalocrotonate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842885.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25999">
        <property type="protein sequence ID" value="KWX25999"/>
        <property type="gene ID" value="AFM11_01705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.351"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="104"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="263" mass="27623" checksum="846D8529B5D14934" modified="2016-06-08" version="1">MSTEPEWNVQTAAEVLLDAEKTRTDRGPITGDWPGLDLETAYDVQAELMARKVAAGQHIVGVKLGLTSRAKQLRMGVDSPLTAWLTDAMSLPLGVPVPTAELIHPRVEPEIVFVLGRDLTGPGVTAAQAMESVDAVYAGLEVIDSRFTDFKFTLPDVVADNASSARFVIGGRKCRPADIDLALEACVLQVDGEVVYTAAGAAVQGHPAEALALAANALGRRGVVLRAGWTVLTGGLTDAVFIRPGQQVSAEFTNLGAIVLGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUZ5</accession>
    <name>A0A132PUZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Natural resistance-associated macrophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_02540</name>
        <name evidence="6" type="ORF">AWC31_35315</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843318.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35315"/>
    <dbReference type="EnsemblBacteria" id="KWX26135">
        <property type="protein sequence ID" value="KWX26135"/>
        <property type="gene ID" value="AFM11_02540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11912">
        <property type="protein sequence ID" value="ORX11912"/>
        <property type="gene ID" value="AWC31_35315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.521"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="409" mass="43144" checksum="E0123D519E267B81" modified="2016-06-08" version="1">MKKFFAVALGILTAIGGFLDIGDLVTNAVVGSRFGLALAWVVVVGVIGICLFAQMAGRVAAVSGRATFEIIRERLGPRTAAANLSASFLINLMTLTAEIGGVAIALELATDVGPMMWIPVAAFAVWIVIWRVKFSIMENVAGIMGLSLIVFAVCVFLLQPNWSDLTHQALQPAIPESESSATYWYYAIALFGAAMTPYEVFFFSSGAVEEHWKTKDLGVSRLNVMIGFPLGGILSIAIAACATLVLLPNGIEVTSLSQVVMPVAVAGGKLALAFAIVGIVAATFGAALETTLSSGYTLAQFLGWPWGKFRRPAEAARFHVVMFVSIVVGAAVLFTGVDPVMVTEYSVVFSAIALPLTYLPILIVSNDPEYMGDKTNGRVTNVLGSIYLVIILAASLAAIPLMIVTGAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV29</accession>
    <name>A0A132PV29_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_00025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33130"/>
    <dbReference type="EnsemblBacteria" id="KWX26201">
        <property type="protein sequence ID" value="KWX26201"/>
        <property type="gene ID" value="AFM11_00025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="9">
        <location>
            <begin position="18"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="185"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="289"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX26201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="551" mass="59602" checksum="A8F975ABB22B3AA5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV30</accession>
    <name>A0A132PV30_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_02795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843447.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35575"/>
    <dbReference type="EnsemblBacteria" id="KWX26173">
        <property type="protein sequence ID" value="KWX26173"/>
        <property type="gene ID" value="AFM11_02795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.575"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="190"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="380" mass="41190" checksum="5696D616AF54DE0E" modified="2016-06-08" version="1">MRILHIVALVTPDGAYGGPVRVAMNQTAALHQRGHTVKVAAAASGFPHRPTQLGSVPAELFASMGSVPGLGFASTWAPRMRSWINANASQFDIAHVHLGRDLVTLPAALQLRRLRIPYVCQTHGMIRARSHRLAPVIDRVWTNKLLRDAAEILCLDEREHADLIEIVGPDCNYELLPNGVPPATDYAAARNGRNDDIPEVLFLSRLHKRKHPEVFAEAALDMLRSGMKARFAIVGINQGAETAVDRVIDVAREEGFGENLLVREPGLPPEDVNERLSRASVYVLPAEREPFGLTVAEALSVGTPVVIRDDGGLANFVRRHNCGLCVSGTAESIHEAVSYLLANPTEAEEMGQRGAAAVRAELSSDSVAARLESIYQGLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAQ0</accession>
    <name>A0A132PAQ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_36035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000072">
        <property type="protein sequence ID" value="KWX19406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33440"/>
    <dbReference type="EnsemblBacteria" id="KWX19406">
        <property type="protein sequence ID" value="KWX19406"/>
        <property type="gene ID" value="AFM11_36035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6884"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="211" mass="23337" checksum="8CFF267A69E38EE0" modified="2016-06-08" version="1" fragment="single">QRTSAINRLRWHVHELDPEQAPAARKLKLTTHQQALQDWLQTLAGLIAEIARDELADIIRLTAEINALEKRLAARIRDLAPTLLAIDGCAELTAAKIVGEAAGIERFTSEAAFACHAGVAPIPAWSGANAGQMRLSRSGNRQLNTAIHRIALTQARMEGSQGHTYYHRLIAEGKTKAKARRCLKRRISRRVYQALLTDRQIPHHTQQSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAT2</accession>
    <name>A0A132PAT2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000054">
        <property type="protein sequence ID" value="KWX19428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067860029.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29830"/>
    <dbReference type="EnsemblBacteria" id="KWX19428">
        <property type="protein sequence ID" value="KWX19428"/>
        <property type="gene ID" value="AFM11_35910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6259"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="61"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="462"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="550" mass="59082" checksum="6550D77B3E5B65EA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAX3</accession>
    <name>A0A132PAX3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859794.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02710"/>
    <dbReference type="EnsemblBacteria" id="KWX19485">
        <property type="protein sequence ID" value="KWX19485"/>
        <property type="gene ID" value="AFM11_35540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5843"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="149" mass="16100" checksum="0224ADE604D8750B" modified="2016-06-08" version="1">MAAERIRPPWWLKYVNKVMIGLNKLGVGGDKGPVVLTVPGRKSGKPRSTPVTPMTVDGKRYVVGGLPGADWTANVRAAGEATVHQGRRAQRVRMVEIPAEQARPLLREFPILVPTGVGFMKNAGLVTGPHPDEFEALAGRCPVFRLDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB41</accession>
    <name>A0A132PB41_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-carboxy-cis,cis-muconate cycloisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000044">
        <property type="protein sequence ID" value="KWX19514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043416463.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19514">
        <property type="protein sequence ID" value="KWX19514"/>
        <property type="gene ID" value="AFM11_35500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5834"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="2">
        <location>
            <begin position="78"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="401" mass="41638" checksum="524491FF33104EC2" modified="2016-06-08" version="1">MTDLFWPGDDLAGDLMSGPAFLEAMVAVERAWLDSLVDAGIAPQEARASLADLIADADTESIARRAATDGSPVSALVTLLRERSTAATARWLHRGLTSQDVVDTALVICARDVLMRIGDEFTVQVRALSELAERHRSTPTLARTLTQAALPSTFGAKMARWLTGILDAAEPLTGLLPSLPVQVGGAVGTLAAATELTGSVDGAIALSDALAGALRLAPAPPWHTTRSAITRIGDALVSCCDAWGHIAADIATGSRPEVGELAEGTGGGSSTMPHKNNPVRSVLIRRTALTAGTLGATLHLAAGASVDERSDGAWHAEWATLRTLARHTVVAAIQASELLSGLQVDTARAAANLADAGGLLTEQRAMTELTGSPARPDYTGAADRLIDSTLSRARRFIKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB98</accession>
    <name>A0A132PB98_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal biosynthesis lyase PdxS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19611">
        <property type="protein sequence ID" value="KWX19611"/>
        <property type="gene ID" value="AFM11_35035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="71" mass="7377" checksum="906F8DA145B1B09F" modified="2016-06-08" version="1" fragment="single">MAEMLKGGVIMDVVTPEQARIAEGAGAVAVMALERVPADIRAQGGVARMSDPDMIEAIIDAVTIPVMAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBC2</accession>
    <name>A0A132PBC2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34735</name>
        <name evidence="3" type="ORF">AWC31_10880</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859450.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10880"/>
    <dbReference type="EnsemblBacteria" id="KWX19618">
        <property type="protein sequence ID" value="KWX19618"/>
        <property type="gene ID" value="AFM11_34735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08983">
        <property type="protein sequence ID" value="ORX08983"/>
        <property type="gene ID" value="AWC31_10880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5294"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX08983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="121" mass="13283" checksum="BD80F262B593D121" modified="2016-06-08" version="1">MIGKLRSVVLDCQDPRKLAAFYAEVLGGEVSEEDDTWVVVTDPAGRRLACQYSPRHQPPTFPDPGGSQQFHLDIQVDDADTAQQQVLALGATRVDGAVEDGMFRVFRDPAGHPFCLVWGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBL3</accession>
    <name>A0A132PBL3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TMP_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859195.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19721">
        <property type="protein sequence ID" value="KWX19721"/>
        <property type="gene ID" value="AFM11_34325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5207"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013491">
        <property type="entry name" value="Tape_meas_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20155">
        <property type="entry name" value="TMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02675">
        <property type="entry name" value="tape_meas_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TMP_3" evidence="2">
        <location>
            <begin position="150"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1207" mass="122473" checksum="F8B68B9193968438" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBV0</accession>
    <name>A0A132PBV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_34360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859216.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19727">
        <property type="protein sequence ID" value="KWX19727"/>
        <property type="gene ID" value="AFM11_34360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5217"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="68"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="175"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="380" mass="41232" checksum="2A0044AA0E62CA2B" modified="2016-06-08" version="1">MGTRRADGEGSYRQRPNGLWEASTRYTTPDGQRKRLSVYGKTRAEARGKLNDARKRLAEGAPPRDDKQTVGAWLKTWRTTALPASSRKATTQELYANLCRKHLEGDTDLAGLRLDQLRPTHVETLVMRLRGKGLSDSTVRQVYTVLRAALDIAVRDGLLAGNPAAKVKRPAVAPREARYLSTEDVRRLLSHLDGLRYRLAVLVLAATGMRRGEVAGLRWSDVDLAKGELTVAGIVVRVAGALTWTAPKTDRSRRRIPLTAGLVAELKAHRKKQLAERLHAGDQWTDTGAVFATEVGGWVDPRNLLRTVEIAADKAGIEDVGAHTLRHSAAVGWLESGVHIKAAADLLGHASISITGDLYGHTSDDAARAAVKGLGDALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCG3</accession>
    <name>A0A132PCG3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858313.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32195"/>
    <dbReference type="EnsemblBacteria" id="KWX19994">
        <property type="protein sequence ID" value="KWX19994"/>
        <property type="gene ID" value="AFM11_32820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4893"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="29135" checksum="205C719AD8C03583" modified="2016-06-08" version="1">MNFFDKALDLDSADEGHLRGHTLPEWANMVGPFGGITAATLVRAIEAQPDVHGQPVALTVNYLAPIADGDFDIHTRAVKTNRSNQHWIVELSQDGEPKTSATAVFGLRRDTWADTEITAPQAPAPAEIERAQSPFGVVWFDNYDLRFVDGAMPVHGAASDSSTTTLWVRNNPPRPMDFASLTAVSDIFYPRAFLRRGHFMPAGTISMTVYFHAGAHEIAAQGDGFVLATARAQRFSRGYFDQSAQLWGRNGTLLATTHQIVYFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCM1</accession>
    <name>A0A132PCM1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857992.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20044">
        <property type="protein sequence ID" value="KWX20044"/>
        <property type="gene ID" value="AFM11_32235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4775"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="247" mass="26224" checksum="30660F5A0DDA45C1" modified="2016-06-08" version="1">MKIGILGVGLIGTTLTQRLSAAEHDVKVANSRGPETIEAETLASGGRAVSAAEAVVDVDVIILSIPLNRIPGVAPLFTNVPAETVVIDTSNYYPARDERIEAIEVGQVESLWVIEQLGRPVVKAWNAIGSDSFARKHKPAGDPARIAIPVAADSDTERRVGMALVEDTGFDAVDAGPLAESWRQQPGTPVYCTDLTRAQVPAALAAADAARSPKRRDLAAAAIAERFGHTVNPDAEYAVRLNRVLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCR6</accession>
    <name>A0A132PCR6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_33970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858997.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32480"/>
    <dbReference type="EnsemblBacteria" id="KWX19762">
        <property type="protein sequence ID" value="KWX19762"/>
        <property type="gene ID" value="AFM11_33970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5131"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="117"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="351" mass="37774" checksum="18B5CCE73550700E" modified="2016-06-08" version="1">MRYRGALIGLSLFMVVAVALTWLVYVTLRRDVAGKTVPYAAMFTDVFGLREGDDVRMAGVRVGRVESIELQGDLAKVSFVVQSDQQVLGTTVASVTYQNIVGQRYLGLSLGKLGDPGHLPPGSVIPVERTDPSFDVDTLLNGYEPLFSVLDPQNADNLTKGVIQSLQGDEGSITALVDQTSKLTESFAGQDEKLGEVITDLNVVTANLARHNDDLDHIIGEARTVVSTFDARRPQLVDSMGSIAKVVRQLSTISDEVYPSLNELVTREPGFAAHMVGLEPQLAFTGANLPLLLKGFARITSEGTYANAYACDLNIQGFFPGLNDVVPIIVDAATPGNKAQYTPKCRNMANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCU0</accession>
    <name>A0A132PCU0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20114">
        <property type="protein sequence ID" value="KWX20114"/>
        <property type="gene ID" value="AFM11_32330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4794"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="165"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="454" mass="50599" checksum="317598F1F1AB0819" modified="2016-06-08" version="1">MQPQPGSGTNAAAEEPYIVVSTDSHVGPSLKNQLRQYCEPKYLDEFDEFAAEMEKHGMFSLRSSKAGDKGHDENWSLDQSQAEEFAKTAGIRNPEQMDLGFLNRSYEHSFVPGLQDPAARLADMDEQGVAASVIYHGGLNGESIPFSTTGLISWGDSKYDRLEDLGVRIYNRWLADFVSTAPERSAGIAHIPISDPAACVREVKWAAEAGLKGINLPAPRNDFPMLNDPVWEPLWSICEETGMSLNTHGGGGEHYPYEGEGAQAMYMMETLFRTRRGVWVMILGGVFERHPKLKMVLTEQWMDWAPGVMNDMDGLYHSRTGEWVRAALSMPPSEYFKRNCYIGASFMSNWEAKLGVDEGLTDKVMWGDDYPHAEGTWPDTREAIRFTFNDIDPKHVRKYIGGNAIDVYGLDRAKLAEIAAKIGPTVDEVATPYTVPEDAVMGLYAFRTGPGRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCW4</accession>
    <name>A0A132PCW4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857858.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31855"/>
    <dbReference type="EnsemblBacteria" id="KWX20173">
        <property type="protein sequence ID" value="KWX20173"/>
        <property type="gene ID" value="AFM11_32040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4734"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="263" mass="26809" checksum="D1537E5F24D8923D" modified="2016-06-08" version="1">MSTLNIDRVGDITTLTINRPEAFNALNSEVVSGLAAAVRDAADDPGVRAVIVTGSGEKAFSAGADLKELAGMGPDLAHQTMSRGQQAFRAIERAAISVIAAVNGVALGGGFELILACTIPVLSTKASMGLPESGLGLIPGYGGTQRLPRVVGEKVAAHLMLTGTRIDADRAYSLGLTPVPPVEPAELLSTATAVAEKIAGQGPLAVRAILHALDVGRDGPIDTALGVETGLAALAISGEESTEGIAAFLERRPAKFANPEGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCY6</accession>
    <name>A0A132PCY6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_32135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31715"/>
    <dbReference type="EnsemblBacteria" id="KWX20189">
        <property type="protein sequence ID" value="KWX20189"/>
        <property type="gene ID" value="AFM11_32135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4754"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="126"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX20189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="546" mass="59181" checksum="333BD4F68EE527EF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD32</accession>
    <name>A0A132PD32_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multiphosphoryl transfer protein (MTP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_31385</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18381"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.7.1.121"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857480.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25540"/>
    <dbReference type="EnsemblBacteria" id="KWX20243">
        <property type="protein sequence ID" value="KWX20243"/>
        <property type="gene ID" value="AFM11_31385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4183"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047324">
        <property type="term" value="F:phosphoenolpyruvate-glycerone phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012844">
        <property type="entry name" value="DhaM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02364">
        <property type="entry name" value="dha_pts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="13">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="HPr" evidence="14">
        <location>
            <begin position="151"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX20243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="809" mass="83056" checksum="8018CE00D942DBF1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD66</accession>
    <name>A0A132PD66_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857483.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25545"/>
    <dbReference type="EnsemblBacteria" id="KWX20244">
        <property type="protein sequence ID" value="KWX20244"/>
        <property type="gene ID" value="AFM11_31390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4184"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="4"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="211" mass="21163" checksum="9064702F867EE77E" modified="2016-06-08" version="1">MDLTTLTEWIREYARVIADNAQNLSDLDAAIGDADHGINMERGMTAVIAAFEESAPADMAALCKQVGMTLVKSVGGASGPLYGTFFLRMAPALGSGDAVSDADFAKALRAGVDGVVQRGRAEAGDKTMFDALAPALDALDSALSSGASLADGLAAASAAAEKGRDATESMVARKGRASYLGQRSVGHVDPGATSAALLIAAAAKVAGGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDF6</accession>
    <name>A0A132PDF6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_30895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857178.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26615"/>
    <dbReference type="EnsemblBacteria" id="KWX20360">
        <property type="protein sequence ID" value="KWX20360"/>
        <property type="gene ID" value="AFM11_30895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4081"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="289" mass="30875" checksum="52DE870920AD33C9" modified="2016-06-08" version="1">MTAIGTLLGASVLPRSLTLAPSRTGRKGRRLVVAMGYPLLSLLGALAAWSAVSYGILSPQRRFLLPPPIDVLRDSLLNPAALRPMLAALSVTAQVTAVGFLVAVVVGVGTGILMSQARWIERIIYPYAVVIQVIPILAIVPLIGLWFGYGMAARTLVCVLIAVFPIITNTHFGIRSVNRGLHELFTLSGASRWDRLVKLELRAALPTILTGITTASGLVVVGAIIGDMFFAKGQPGIGTLLDVYRGRLQSDDLIAAIVLASVFGVLVFGAMRVFTRWAVGSWHESAQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE14</accession>
    <name>A0A132PE14_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_29700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856513.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25040"/>
    <dbReference type="EnsemblBacteria" id="KWX20578">
        <property type="protein sequence ID" value="KWX20578"/>
        <property type="gene ID" value="AFM11_29700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3832"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="13"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="486" mass="49531" checksum="86878EF7D838F293" modified="2016-06-08" version="1">MSAQIQHLVGGEWLTGSGGELRSLNPARPSIVVAEGAGAVVSDVDAAVAAAGEAFAAWAATPIHQRGAVLLAAADVADRNAEAWGLELATEEGKTRAEGVGEVRRAAQILRYYGNEGDRQAGEIFASPRAGEQILVTRKPIGVVGVITPFNFPIAIPAWKIAPALVYGNAVVWKPASTVPLLAMRLAEALTAAGLPAGVLNLLVGGSAIGDAIVGHTGIDAITFTGSTGIGRRIASAAAARGVPVQAEMGGKNAAVVLDDADLDLAVEQVMLGAFRSTGQKCTATSRLIVTDGIADRFLAVLAERARALTVGDPTDDTTQMGPVVNDSAHKSISTGIDTAAAQGATLVAGGVPYTDGPLAEGYFIPPTVVELNGTSADVWTEELFGPVLAVKRAGDADEAFALANDSEFGLSAAVFTQDVTRALQAVDHIDVGVLHINSESAGADPHVPFGGAKKSGLGPKEQGGAAREFFTHTTTVYLRGGKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE64</accession>
    <name>A0A132PE64_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856662.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25335"/>
    <dbReference type="EnsemblBacteria" id="KWX20628">
        <property type="protein sequence ID" value="KWX20628"/>
        <property type="gene ID" value="AFM11_29995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3891"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="203" mass="22230" checksum="A143B0A6AC12826A" modified="2016-06-08" version="1">MAAGELSSKGRQTRSAIELAARKLFAERGFHGTTLADITSAAGKSPAVFYRYFDDKEDLLAALAESFLHDVVEPSGLNLHLPDSPDDTEFFTAVVTGYWNIFKQNIGIMIAVAQLAATQQRFADVQNEFRRFGIDIVAASVERAQEQGHARDLNPQHVAAAIALLFENFTTVFVGPSTLGIELTDSEAITTLSTIWKKTLYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PED0</accession>
    <name>A0A132PED0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040146.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20698">
        <property type="protein sequence ID" value="KWX20698"/>
        <property type="gene ID" value="AFM11_29195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3723"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="42"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="347" mass="38434" checksum="4BEBF2F3A685A7B5" modified="2016-06-08" version="1">MAEAPGAVQRQAWVDGVLPPVEQVRPGLWSIPVPIPDNPLRYVLVYAFELPDGVAIVDAGWDTEEAWTALVEGLSKAGCDITDVSAVLITHVHPDHYGLAGRVREHSGAWVGVHPADAAVLPTRYGEVEPLVASMRDLLVDCGVPEVELDELSSASLGIRQFVRQAEPDRFIDDGDRLPLPGWNLRAIWTPGHSPGHLCFAEPDRRLMLTGDCVLPRITPNISVHPQQAANPLADFLASLAKLRGYQPDEVLPAHEYRFDAFTTRLDELFAHHRTRLGEIERAVADCPGATCWQITTRLGWSRPWAQVPNFMRRAANGETLAHLALLAAEHRVEPMRDTVTTWWPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEJ5</accession>
    <name>A0A132PEJ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856062.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20758">
        <property type="protein sequence ID" value="KWX20758"/>
        <property type="gene ID" value="AFM11_28335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3541"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="74" mass="7760" checksum="8729EED9A6B6D8DE" modified="2016-06-08" version="1">MAKKRWSELSTTARAAIIGMAAADAGLRAWALRDLAGRKADQVNGPKWLWAGALGVLSTPGVIPAAYLVVGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEL9</accession>
    <name>A0A132PEL9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_28440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856118.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20775">
        <property type="protein sequence ID" value="KWX20775"/>
        <property type="gene ID" value="AFM11_28440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3566"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="167"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="241" mass="26433" checksum="3A5815806548BFE3" modified="2016-06-08" version="1">MDRYERLANAFVGLADTLVADYDVVELAQQLIDSSMSLLPIAAAGIVLGDAYGELHVFASSSEQTWLLELLELESGMGPCLEAYRTGQPNIVDDLTVDPQRWPAFAERAGEYEFRSMTALPMRLREERVGALNLFRAESGPLSHSDVAVGQALADVATIGILHQRIMTRSELVNQQLQTALNTRVVIEQAKGVLAERGAIDMDEAFLVLRNHARSTHRRLADLAREVVDGTDTTAILADTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PES4</accession>
    <name>A0A132PES4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Immunogenic protein MPT63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_30460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20492">
        <property type="protein sequence ID" value="KWX20492"/>
        <property type="gene ID" value="AFM11_30460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3991"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015250">
        <property type="entry name" value="MPT63-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09167">
        <property type="entry name" value="DUF1942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453036" evidence="2">
        <location>
            <begin position="30"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1942" evidence="3">
        <location>
            <begin position="36"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="197" mass="20264" checksum="3385EEF810EB6EE2" modified="2016-06-08" version="1">MRIRGKLAAMAAMLMFAVLGVLGAPHAAAASDPCPHRFGAPQRLTEANGAMATQWSVSGLGVSTDQLAGYATAGRLWEADATVEAVTGTVTPIIPNMYAVSRSGERYQVLWQVAAPQTVAPNTLSQGQQSSGKLYFDVTGAEPMAIIYASGGSAPAMMWCCNGQMQMPMSGGMAMAMGDGSCCGATTPYPCCAGICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF01</accession>
    <name>A0A132PF01_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855722.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10355"/>
    <dbReference type="EnsemblBacteria" id="KWX20901">
        <property type="protein sequence ID" value="KWX20901"/>
        <property type="gene ID" value="AFM11_27825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3439"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="143" mass="15318" checksum="7289C558050EB1A4" modified="2016-06-08" version="1">MAKLELTRELPISPESAWEHASNLEGLGDWLVMHEGWRSDVPTELTVGTTLVGVAGAKGMRNRVTWTVQKIDPPQLLEVTGKGVGGTKYGLKMRVKPTASGCAFAVTIDLGGPPLFGPIGSVAARAVKGDIERSIKQFEMLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF33</accession>
    <name>A0A132PF33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855862.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10680"/>
    <dbReference type="EnsemblBacteria" id="KWX20945">
        <property type="protein sequence ID" value="KWX20945"/>
        <property type="gene ID" value="AFM11_28135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3502"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="7"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="376" mass="40107" checksum="52314EA4955E6299" modified="2016-06-08" version="1">MHTALCDELGIEFPIFAFTHCRDVVVAVSKAGGFGVLGAVGFTPEQLEIELNWIDEHIGDHPYGVDIVIPNKYEGMDANMSADELKGMLQSLVPQEHLDFAKKILADHGVPIDDSDDNALQLLGWTEATATPQVEIALRHPKMTLIANALGTPPADMIKNIHAQGRKVAALCGSPSQARKHADAGVDIIIAQGGEAGGHSGEVGSIVLWPQVVKEVAPVPVLAAGGIGSGQQIAAALALGAAGAWTGSQWLMVEEAENTPVQQAAYAKASSRDTVRSRSFTGKPARMLRNDWTEAWERPENPKPLGMPLQYMVSGMAVAATHKYPNETVDVAFNPVGQVVGQFEKVEKTSAVIERWVQEYLDATATLNNLNEAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFD7</accession>
    <name>A0A132PFD7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855282.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06920"/>
    <dbReference type="EnsemblBacteria" id="KWX21045">
        <property type="protein sequence ID" value="KWX21045"/>
        <property type="gene ID" value="AFM11_27075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3289"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="26911" checksum="669A7D8C98B44B26" modified="2016-06-08" version="1">MKAEVSQQRSLLELTEVDAELARIEHRAKHLAEQKRLDEAQAEYGAANDRLATLGIALEDLGTQVAKFETEIDAVRQREDRDRALLESGGVGAKQVTEIQHELETLQRRQSSLEDSLLEVMERREELLAQQAEALRRIDELQTALSDAQQARDGALVEIDQSRHQCVTRRDALVDAIDDELVGLYERQRARGGAGAGLLQGRRCGACRIEIDRGEIARISAAADDDVLRCPECGAILLRVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFL8</accession>
    <name>A0A132PFL8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraZ</name>
        <name evidence="10" type="ORF">AFM11_27445</name>
        <name evidence="11" type="ORF">AWC31_07380</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855592.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07380"/>
    <dbReference type="EnsemblBacteria" id="KWX21149">
        <property type="protein sequence ID" value="KWX21149"/>
        <property type="gene ID" value="AFM11_27445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10005">
        <property type="protein sequence ID" value="ORX10005"/>
        <property type="gene ID" value="AWC31_07380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3363"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX10005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="143" mass="16130" checksum="0EA19725C1A6C2F8" modified="2016-06-08" version="1">MFLGTYTPKLDDKGRLTLPAKFRDALAGGLMVTKSQDHSLAVYPRDEFEKLARRASQASRSNPEARAFLRSLAAATDEQHPDAQGRITLSADHRRYANLSKDCVVIGSVDYLEIWDAQAWQEYQQTHEENFSAATDETLRDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGQ2</accession>
    <name>A0A132PGQ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27080"/>
    <dbReference type="EnsemblBacteria" id="KWX21444">
        <property type="protein sequence ID" value="KWX21444"/>
        <property type="gene ID" value="AFM11_24825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2326"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="234" mass="26061" checksum="DD106C431D6BFCA8" modified="2016-06-08" version="1">MTEASRKPLRERAYDELRARIVGLELAPGTRLIERDLADELAVSRIPLREALQRLQQDGLVVTVPHQGTIVSPFTADDVRDLFDVRESLEVLAARLAAERADQHGLDKLAAQLDIARRATKRKDKSAIAAANARFHGVIVELAANPLLETMLRPLEARTQWLFHLTKDRDPGVQCREHEELLAAIADHDPDRAAASAFHHVHSGRADSLAMAATWSSTDLDPVQLTRSRRRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGV6</accession>
    <name>A0A132PGV6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein AFM11_25395</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25395</name>
        <name evidence="4" type="ORF">AWC31_27715</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854298.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27715"/>
    <dbReference type="EnsemblBacteria" id="KWX21543">
        <property type="protein sequence ID" value="KWX21543"/>
        <property type="gene ID" value="AFM11_25395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14931">
        <property type="protein sequence ID" value="ORX14931"/>
        <property type="gene ID" value="AWC31_27715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2441"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX14931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="122" mass="13548" checksum="2E4915665D51C5F0" modified="2016-06-08" version="1">MTSLTRAEIGALGEQLAVDHLTAAGLRTLVRNWRCRYGELDVIAEDPDARTVVFVEVKTRTGDGFGGIAEAVTAQKVRTIRRLAALWLAEQDTRWAEVRIDVIGIRIGRRREPELTHLKGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH12</accession>
    <name>A0A132PH12_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lycopene cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_24880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854327.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27135"/>
    <dbReference type="EnsemblBacteria" id="KWX21554">
        <property type="protein sequence ID" value="KWX21554"/>
        <property type="gene ID" value="AFM11_24880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2337"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016120">
        <property type="term" value="P:carotene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18916">
        <property type="entry name" value="Lycopene_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Lycopene_cyc" evidence="9">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="113" mass="12788" checksum="8AF4E528E9A88312" modified="2016-06-08" version="1">MSGLGYTLPAVIAVGVVIALELKVFRTGIFGTATYWISMAIVLGFQIPVDGWLTKLSAPIVLYDDRHTTGIRFPWDIPVEDFLFGWAMVTAVLILWQYQRKRYAKEADREHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH21</accession>
    <name>A0A132PH21_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23960"/>
    <dbReference type="EnsemblBacteria" id="KWX21626">
        <property type="protein sequence ID" value="KWX21626"/>
        <property type="gene ID" value="AFM11_24155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2190"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="27738" checksum="F227DD41AA2FAFC1" modified="2016-06-08" version="1">MGVATAKIVGRDHAVVLCDVRQDRLDAAVAALADLGISATAVDCDVTERQAVDRLFGTAAELGPVAAVIHAAGVSPSMGDAAYVMRTNALGTLNVNEAFYENAGEGSAIVNVASMASYMLPDEIVPAEHFPLALDDPDAFVKTLLATCDMAPEEARSGFAYALSKTFVRWYSSSQAERFNGRGLRIVSVSPGSVDTEMGRLEEQAGAGAMVADAAVPRWGKPEEMAELFAFCVSAKAGYLTGTDILNDGGVVASMRERARAAAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHS6</accession>
    <name>A0A132PHS6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoniazid-inducible protein iniA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_23425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853182.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28150"/>
    <dbReference type="EnsemblBacteria" id="KWX21804">
        <property type="protein sequence ID" value="KWX21804"/>
        <property type="gene ID" value="AFM11_23425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2040"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin_N" evidence="3">
        <location>
            <begin position="50"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="570"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="614" mass="67648" checksum="AB1520AAC207DB29" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHU1</accession>
    <name>A0A132PHU1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_22285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08925"/>
    <dbReference type="EnsemblBacteria" id="KWX21905">
        <property type="protein sequence ID" value="KWX21905"/>
        <property type="gene ID" value="AFM11_22285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1807"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03256">
        <property type="entry name" value="ABC_PhnC_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012693">
        <property type="entry name" value="ABC_transpr_PhnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02315">
        <property type="entry name" value="ABC_phnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="28446" checksum="3758742FF80240A6" modified="2016-06-08" version="1">MGAGTALSDTHAVTASATALEVANLRVRYGRGGAEALRGVDLKVPPGQTVALIGTNGAGKSTLLRCLVRLIEPTQGAVVIHGTDVTALSRGRLRAVRRDVGFVFQRFHLIPRLSAFHNVVHGAMGHRGTRCAWTLTSPREVRADAMTSLERVGLSAFADRRVDTLSGGQQQRVAIARMLMQRPSLILADEPVASLDPASAQAVMELMRSIAAERDVTVIMALHQIDLALRYADRVVGLRNGVVEFDRPAAECDAAQLNPVFAEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHW6</accession>
    <name>A0A132PHW6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22515</name>
        <name evidence="3" type="ORF">AWC31_08695</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852748.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08695"/>
    <dbReference type="EnsemblBacteria" id="KWX21940">
        <property type="protein sequence ID" value="KWX21940"/>
        <property type="gene ID" value="AFM11_22515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10231">
        <property type="protein sequence ID" value="ORX10231"/>
        <property type="gene ID" value="AWC31_08695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1853"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="40"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="229" mass="24485" checksum="E90D9890CC7B3222" modified="2016-06-08" version="1">MTPTNITVDDTYTGHVDPGTAARRTLANASIIKVSVGPMDNNCYLVTCTSTGETLLIDAANDADVLLELIKQYAPELVLIVTSHQHFDHWQALEAVAKSTGVPTAAHQLDAEPLPVTPDRILADGDTIRVGDLSLDVIHLRGHTPGSVALALSGADESGATHLFTGDCLFPGGVGKTWQPGDFERLLGDVTTKVFDVYDDNTVVYPGHGDDTSLGAERPSLAEWRERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI13</accession>
    <name>A0A132PI13_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852822.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21976">
        <property type="protein sequence ID" value="KWX21976"/>
        <property type="gene ID" value="AFM11_22730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1898"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453309" evidence="1">
        <location>
            <begin position="26"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="235" mass="24843" checksum="9A063C710F874CAB" modified="2016-06-08" version="1">MRKHLRNLLVGVSAIIALGAIPACSGGSSTEAETSGSAAPTTTSAAAPLPASVRYMADMESEGKKMTIGISVDGNNVTAYACNGVDDEAWFFGNQTDGNIDITSKFRDTLKADFTATDATGDLTMNGVNYKFTAAAVADPAGMYTADYEGVRASWVVRPDGSAVGVQFNGGISGRDFEQAELQQLNAQQFQSQVRNKRKLQQAQQLLRLQNGTFTSKINGHDVVASLVTGNTRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI23</accession>
    <name>A0A132PI23_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osmotically inducible protein OsmC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24340</name>
        <name evidence="3" type="ORF">AWC31_23775</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853701.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23775"/>
    <dbReference type="EnsemblBacteria" id="KWX21652">
        <property type="protein sequence ID" value="KWX21652"/>
        <property type="gene ID" value="AFM11_24340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15582">
        <property type="protein sequence ID" value="ORX15582"/>
        <property type="gene ID" value="AWC31_23775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2227"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="31"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="253" mass="26871" checksum="35580CD9C24970BC" modified="2016-06-08" version="1">MAERVSFPSSTGPMLAGSIDLPEGPVRGWGVFSHGFTLGKNSPAASRICKQLASDGIGMLRFDALGLGESEGDWGDGSFTHKVDDIIEACKFMTERGTPADILIGHSFGGAAVLAAARQAPGVRAVVTVGAPIDPVHVEHQYDACLEQVFAEGSGQWMVGGRTLTLKRAFVEDVRAAHLHDKIKALKMPLLILHSPTDNTVGIENASAIFRTARHPRSFVSLEGSEHLLTGPGQAHRAGRIIGAWADAYLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI64</accession>
    <name>A0A132PI64_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853819.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23520"/>
    <dbReference type="EnsemblBacteria" id="KWX21692">
        <property type="protein sequence ID" value="KWX21692"/>
        <property type="gene ID" value="AFM11_24600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2281"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="206" mass="22139" checksum="C07F40B4AA19C4BF" modified="2016-06-08" version="1">MPRPRVYDPDVVLDAAESLAVASGPAAVTVRAISDAVGLSNGALYHTFGSRAGLLARTWLRGGRRFLDVQRELVADARPGLDAIAAAAQAPVTFAERCPDSAALLLRMRRDDVLGPDTPGEYAAEIAELEKLLVELMIQLASDAWGRRDRAAVDAVTTCIVDLPTAILLHRNRLADPTARRHLRAAVDAVLAVGPAPQKPREREQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI93</accession>
    <name>A0A132PI93_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsB</name>
        <name evidence="7" type="ORF">AFM11_21305</name>
        <name evidence="8" type="ORF">AWC31_04120</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852282.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04120"/>
    <dbReference type="EnsemblBacteria" id="KWX22055">
        <property type="protein sequence ID" value="KWX22055"/>
        <property type="gene ID" value="AFM11_21305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10495">
        <property type="protein sequence ID" value="ORX10495"/>
        <property type="gene ID" value="AWC31_04120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1608"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX10495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="277" mass="30185" checksum="697D6C9BA56DAD6E" modified="2016-06-08" version="1">MAVVTMKQLLDSGTHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQQTLTYIDKAYEFVKETVAHGGSVLFVGTKKQAQESIADEATRVGMPYVNQRWLGGMLTNFSTVHKRLQRLKELEAMEQTGGFEGRTKKEILMLTREKNKLERSLGGIRDMQKVPSAIWVVDTNKEHIAVGEARKLGIPVIAILDTNCDPDVVDYPIPGNDDAIRSAALLTKVIASAVAEGLQARAGQGSGEKPEEGAEPLAEWEQELLAGATAGAADSPAGGATSTESSTDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIM6</accession>
    <name>A0A132PIM6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Cobinamide adenolsyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21910</name>
        <name evidence="2" type="ORF">AWC31_04715</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852478.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04715"/>
    <dbReference type="EnsemblBacteria" id="KWX22153">
        <property type="protein sequence ID" value="KWX22153"/>
        <property type="gene ID" value="AFM11_21910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10593">
        <property type="protein sequence ID" value="ORX10593"/>
        <property type="gene ID" value="AWC31_04715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1730"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="204" mass="22554" checksum="1BEE6CC4E1CBC355" modified="2016-06-08" version="1">MPQGQPVAVPDDGLTTRARRNAPLLAVHTGPGKGKSTAAFGMALRAWNQGFSIAVFQFVKSAKWKVGEEAVFRELGRLHDEHGAGGPVEWHKMGSGWSWTRKHGSEDDHAAAAADGWAEIRRRLAEERHDFYVLDEFTYPLKWGWVDVDDAVATLADRPGRQHVVITGRDAPQALVDAADLVTEMTKIKHPMDVGRKGQKGIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIT4</accession>
    <name>A0A132PIT4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852519.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04840"/>
    <dbReference type="EnsemblBacteria" id="KWX22174">
        <property type="protein sequence ID" value="KWX22174"/>
        <property type="gene ID" value="AFM11_22035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1755"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="26649" checksum="151223C25FBF5F6B" modified="2016-06-08" version="1">MTDTLLIDTTDRVRTLTLNRPQSRNALSAELRTAFYGALRDAQADDDVDVVIVTGADPVFCAGLDLKELGDTTELPDISPKWPAMTKPVIGAINGAAVTGGLELALYCDILIASEHARFADTHARVGLLPTWGLSVRLPQKVGVGLARRMSLTGDYLSATDALRAGLVTEVVAHDELLPAARRVAAAIVGNNQAAVRALLGSYHRIDESQTNQGLWIEAASAREWMATATGDDIAANRAAVIDRGRAQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ57</accession>
    <name>A0A132PJ57_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate--ammonia ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852224.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06580"/>
    <dbReference type="EnsemblBacteria" id="KWX22341">
        <property type="protein sequence ID" value="KWX22341"/>
        <property type="gene ID" value="AFM11_21215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1589"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="117"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="460" mass="50850" checksum="3BC09EDBB5F7B551" modified="2016-06-08" version="1">MTDTIFERNDTLYSLDPEHTRVAKELGAQGVKYAMANWIDVLGRPKSKIVPMTHFADLVAGAERYTPRGFGGIGNMNPTEDEVVGVPDLSTLKILPWDRRYAWMIADMSYGGREPFALCPRNALRTQVEAAAAQGYSVHLGVEPEFYVFRPESLDGGHDRLVPVARSGSLKPSPAYDVEATLDASEFLDTLVGYLGELDFGVYAFGHEGGDGQYELSIGHAPVLEMADRMTLFRFAVKQIAKECGLLATFMPKPYASMWGSGAHLNMSLVSLETGRNAFRRGDTAGEWTETTYQFIAGVLKHAPAFTALGNPTTNSYRRLTPRLADGQISWAPTRVSYGSNNRSCTVRLPQNRACIEYRAADSAANYYFASALMIAAGLEGIREGLDPGKPLEQASHNSDAPVLPRTLLEAIEAFQSDPLVHKTFSPAFVSEYTEMKLKEWEADHLLVSDNERRRYLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ64</accession>
    <name>A0A132PJ64_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851829.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11060"/>
    <dbReference type="EnsemblBacteria" id="KWX22386">
        <property type="protein sequence ID" value="KWX22386"/>
        <property type="gene ID" value="AFM11_19720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1278"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="74" mass="8128" checksum="D9B72EB985AC43BE" modified="2016-06-08" version="1">MLTAVRKVLSFQMTIAEWIGTAIILAVPYLIIGMVWSLTHTEHLHGMSRADAVVSVLGSIVSWPVLLFTNVCMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKY1</accession>
    <name>A0A132PKY1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851720.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22662">
        <property type="protein sequence ID" value="KWX22662"/>
        <property type="gene ID" value="AFM11_19395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1212"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="29127" checksum="2B0FD14BDC05F069" modified="2016-06-08" version="1">MTTPLLSVENLVVEYPVAGGVFRAVDKVSFDVPKGSTLAVVGESGCGKSTIAKAIVRLVTPASGHIRVDGTDIAQLSERALRPYRSRIQMVFQDPYGSLDPHLSAVDIVSEPLRLRGIRSRVAREKRAAELIDRVGLPSTALQRKPAEFSGGQRQRIGIARALASEPELLVCDEATSALDVSVQAQVLELLREIKRDTGLTYLFISHNLGVVREISDTIIVMSSGTIVETGVTADVLARPAEPYTQALRAAALDPTTMTGLKPRHLLKGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL24</accession>
    <name>A0A132PL24_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851358.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22887">
        <property type="protein sequence ID" value="KWX22887"/>
        <property type="gene ID" value="AFM11_18520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1038"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="139" mass="15115" checksum="B5E7BA1B28DE5022" modified="2016-06-08" version="1">MIISAQRFSFKPGVAENDKRRALASVAALAEAEPVAFAVVGEDLGDPADGFTHGFSIGLADLGALERYFDDPLHAAADRALLPLLQKTVGTGLSDDDDPDLRSKIIELHQRRADRDPEYLALLTAIPEIALLHETRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLC5</accession>
    <name>A0A132PLC5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_17235</name>
        <name evidence="10" type="ORF">AWC31_01800</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850913.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01800"/>
    <dbReference type="EnsemblBacteria" id="KWX23103">
        <property type="protein sequence ID" value="KWX23103"/>
        <property type="gene ID" value="AFM11_17235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13287">
        <property type="protein sequence ID" value="ORX13287"/>
        <property type="gene ID" value="AWC31_01800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.800"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004751">
        <property type="entry name" value="Drug_antiport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00900">
        <property type="entry name" value="2A0121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="8"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX13287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="406" mass="42394" checksum="D4BC2812FE4B0269" modified="2016-06-08" version="1">MTNTKRGPLLLILFAALMAGAGNGISIVAFPWLVLQRNGSALDASIVAMAGTLPLLVATVIAGAAVDYLGRRRVSMISDLLSALSVAAVPVLALTFGVDAVNVAVLAVLAALGAFFDPAGMTARETMLPEAAGRAGWTLDHANSVYEAVFNLAYIVGPGIGGLLIATVGGINTMWVTALAFLFSIAAISVLRLEGAGKPDRTELPEGVWSGIVEGLQFVWRTPVLRTLAIVDLVATGLYMPMESVLFPKYFTDRDEPQELGWVLMALSIGGLLGALGYAVMSKYMSRRATMLTALLTLGVAMTVIAFLPPLPLILLLCAVVGFVYGPIAPIYNYVMQTKAPQHLRGRVVGVMGSLAYAAGPLGLIVAGPLADSVGLHATFLALSLPMLVLGLVAVGLPALRQLDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLC7</accession>
    <name>A0A132PLC7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_17050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01620"/>
    <dbReference type="EnsemblBacteria" id="KWX23155">
        <property type="protein sequence ID" value="KWX23155"/>
        <property type="gene ID" value="AFM11_17050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.763"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453110" evidence="2">
        <location>
            <begin position="27"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="SLT_2" evidence="3">
        <location>
            <begin position="171"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="430" mass="42640" checksum="BE7AB99F1F5BD761" modified="2016-06-08" version="1">MSGPSARGVVGVAALTPLILAGAVGAAAPPHPGSTNASVTPLAAVEPQIDRTGPAVVAAAKAPTMFRIAASTASAPPPAFVVNTPGALGIPGMALNAYRNAERMMGAAYPGCGVSWNLLAGIGRIESMHANGGATDARGTAVRPIYGPALDGTLPGNEIIVQSAQAGRVVYARAMGPMQFLPGTWARYASDGDGDGKADVQNVFDASLAAARYLCSGGLNLRDQSQVMTAILRYNNSVAYARNVLGWAAAYATGVVPVDLPPITGSIPPIGDSHLDDPEGLGPGLPTSALGLPAGDPLALIPLLNNNETASRVPSTNVPGFAPGQILGPLPGPAQAAPTPAPAEPPRWIPPWEQPPRQPTCVVFCLGEQAPPPPAGPAPLLPGPPPPPAAPAAPPAPAAPPAPTAPPIVPMAPAPGPALGPAPGPAPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLE4</accession>
    <name>A0A132PLE4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_17345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850957.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23123">
        <property type="protein sequence ID" value="KWX23123"/>
        <property type="gene ID" value="AFM11_17345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.822"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453393" evidence="2">
        <location>
            <begin position="33"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="3">
        <location>
            <begin position="56"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="223" mass="23463" checksum="3C194F8BDBFAB484" modified="2016-06-08" version="1">MWKRTTLVGAGALVAVAVAAGCSNTSETQPTAAGPSASVTASSEVSAQSQAHNDADVMFAQHMIPHHQQAVEMSDMLLAKQGIDPRVTDLATQIKGAQGPEIEQMQRWLDEWGNPPMPPMSPPSGDMGHGGHGNMDHGNMSGGMAGMQGMMSEADMTALQNAQGVEAAKLFLTQMIAHHEGAITMAQDEIDGGQFPDAVEMARTIVTTQQQEIDTMRGLLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLP1</accession>
    <name>A0A132PLP1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-keto-3-deoxy-galactonokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850560.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16070"/>
    <dbReference type="EnsemblBacteria" id="KWX23259">
        <property type="protein sequence ID" value="KWX23259"/>
        <property type="gene ID" value="AFM11_15695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7262"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008671">
        <property type="term" value="F:2-dehydro-3-deoxygalactonokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007729">
        <property type="entry name" value="DGOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042257">
        <property type="entry name" value="DGOK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042258">
        <property type="entry name" value="DGOK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05035">
        <property type="entry name" value="DGOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="331" mass="35109" checksum="25F45E74D620B7EA" modified="2016-06-08" version="1">MHNTSPRLIALDWGTSALRAWLLADDARIVDARQRGSGLLNVTAGADAQTPARDYATAFADICADWLQAYPGLPAIACGMVGSAQGWREAGYLTVPTALVIDAQSMTAVPHERGILHLIPGLRVEHDGTGNPADVMRGEETQLIGIMEMLDQPAGEQLIVLPGTHTKWVKISDRQVISFSTAMTGELYGLLMHHGILARTATAGTADADAAFARGLDADRSRGLSSALFGARALVLEDQLEAAALADYVSGLLIADEVAHLLPENLGEQRIILCGNPALCRRYESALARHNVRPAASVTEEAAARGLWTVAVDAGLLSPADPNAQRIEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLW5</accession>
    <name>A0A132PLW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850489.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16770"/>
    <dbReference type="EnsemblBacteria" id="KWX23341">
        <property type="protein sequence ID" value="KWX23341"/>
        <property type="gene ID" value="AFM11_16165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7358"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="261" mass="28018" checksum="7F8F4406A8C7BF8E" modified="2016-06-08" version="1">MSSRNSESEPALVFDDVSVVRGGRLIWSEGTFEIPAGGIVALIGSNGSGKSTMLQVVLGLLPVASGSVRVLGSRPGERNDLIGYVPQDYVADAGEAIRARDAVTLGLTGRRWGFSRTTRSDKERVAEALEWVEATEFADMRVSQLSGGQRQRVALANALVGHPKLLILDEPLAALDLRNQHEIVQLLARLNNELGITIVVVAHDLNPLLAVLDSAIYLLDGHAHHAAIDEVVDADLLTHLYGTKVQVANTLQGQMYMRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM46</accession>
    <name>A0A132PM46_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849681.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09450"/>
    <dbReference type="EnsemblBacteria" id="KWX23406">
        <property type="protein sequence ID" value="KWX23406"/>
        <property type="gene ID" value="AFM11_14020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6908"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02588">
        <property type="entry name" value="HAD_L2-DEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="225" mass="24216" checksum="CBDA86085D5137BE" modified="2016-06-08" version="1">MRPEVLVFDVNETLIDIDSLQTHFDRIFGDPAVLREWFGQLVMYSMAVTLSGGYTDFFSLGQAVLRMTADIRGVAIDDDDLRGLADGMRTMPAHPDVAEGLQRLRDNGFRLATLTNSPHQDGPTPLEHAGLAGFFEHQFSVDEHRVYKPSTVLYTSAADTLGVAPSSCMMVAAHMWDTLGAQAAGFSGALITRPGNASLPAPGVAQPTVVATDLLQLNAILEGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM70</accession>
    <name>A0A132PM70_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849728.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09245"/>
    <dbReference type="EnsemblBacteria" id="KWX23429">
        <property type="protein sequence ID" value="KWX23429"/>
        <property type="gene ID" value="AFM11_14155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6936"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="320" mass="32703" checksum="3313DA4B9FC4D019" modified="2016-06-08" version="1">MKALVAQALTGTAGLAYADVPEPESHDAVIVDVGAAGVCFPDLLLLRGEYQLRLEPPFIPGMEVAGTVRSAPEGSGFTPGQRVSAFTMLGGYAEQVAVNPSGVIPTPDGLDDGAAASLLGNYYTMQFALTRRGALQPGETVLVLGAAGGIGTASIQLAKALGARVIAMVHRPGAEEYISGLGADVVLPLTDGWRQAVLDATDGRGVDMVVDPIGGEAFDDAVRVLATEGRLLVIGFAAGGIPTVKVNRLLLRNVSVVGVGWGEFVNRTPGAQAEVGAQLGKLVADGLRPPPPVRYPLSDGVAALDALAGGQVRGKLVLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMJ1</accession>
    <name>A0A132PMJ1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_14985</name>
        <name evidence="7" type="ORF">AWC31_17920</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850002.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17920"/>
    <dbReference type="EnsemblBacteria" id="KWX23560">
        <property type="protein sequence ID" value="KWX23560"/>
        <property type="gene ID" value="AFM11_14985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17205">
        <property type="protein sequence ID" value="ORX17205"/>
        <property type="gene ID" value="AWC31_17920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7107"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX17205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="167" mass="17483" checksum="C565FDC15B56FC2D" modified="2016-06-08" version="1">MAGDTTITVVGNLTADPELRFTPSGAAVANFTVASTPRIYDRQSGEWKDGEALFLRCNIWREAAENVAESLTRGSRVIVTGRLKQRSFETREGEKRTVVEVEVDEIGPSLRYATAKVNKASRSGGGGGGGFGGGGGGGSRQSEPKDDPWGSAPASGSFSGADDEPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMK9</accession>
    <name>A0A132PMK9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit A</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_14625</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849882.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23504">
        <property type="protein sequence ID" value="KWX23504"/>
        <property type="gene ID" value="AFM11_14625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7034"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="13">
        <location>
            <begin position="256"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="12">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="870"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX23504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1255" mass="138327" checksum="D89EF5C8CC4F1227" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMM0</accession>
    <name>A0A132PMM0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23590">
        <property type="protein sequence ID" value="KWX23590"/>
        <property type="gene ID" value="AFM11_14235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6954"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="97" mass="10764" checksum="B486FD442D545095" modified="2016-06-08" version="1">MDGRVFQVNLSPQVARMTESELAAEIVAVCTLTSRQADATRHHILATLMSELGQDPVSSRAFLEHTIGLPSPQTVLDEKARMFADYYSDRDQGDQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMS7</accession>
    <name>A0A132PMS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_12590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02850"/>
    <dbReference type="EnsemblBacteria" id="KWX23638">
        <property type="protein sequence ID" value="KWX23638"/>
        <property type="gene ID" value="AFM11_12590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6608"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="397" mass="44038" checksum="F694764CE8968355" modified="2016-06-08" version="1">MLRNPTAVPAYRHDIYTRAAILDPYPHYRAMRELGPVVWLARHRLYALPRYAECKATLRDDGRYLSGHGVAANPLTNRLSRGTTLNSDGADHDRRRKLVAHRLMPRALRSLGDDVDTQARSLVDDAVRRGTVDAVADLATALPLAVVPDLVGWPRDERAHLLNWAAATFDILGPANWQALKAVPRSLHMLRFARRVVRERNVLPGSMAHELLTAVDEDGLAAEDVPPLLIDYIAPSLDTTISAISSALYLFATHPEQWHLLKEEPALLSNAVNEIVRFESPLRAFTRKVLQETEIGGTQLPAGARVLVMYASANRDEREWDAPDVFDIRNNAGRHVGFGSGAHACAGQGLARLETTAMLQALIERVDRIEIAAEPTWAVNNVIHRHEHLPVRLIPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMV5</accession>
    <name>A0A132PMV5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome C assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_12780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849068.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03100"/>
    <dbReference type="EnsemblBacteria" id="KWX23668">
        <property type="protein sequence ID" value="KWX23668"/>
        <property type="gene ID" value="AFM11_12780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6648"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="7">
        <location>
            <begin position="107"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="322" mass="35538" checksum="BC2112F79F182F0E" modified="2016-06-08" version="1">MNTEHIDIGLARYSDWAFTSSVLVLVGGLLLLAVELAYSRSRRVETRELVGATVGADSATPGVVLDEPKRSFDERIGKTGLALTYVGIGLLLVCIVLRGLATSRVPWGNMYEFINLTCFCGLVAAAVVLRRPQYRTLWVFVLLPVLILLTVSGRWLYTHAAPVMPALQSYWLPIHVSVVSLGSGVFLVAGVASILFLVKMSPLAERDNGFGRVIQRLPDAQTLDRIAYRTTIFAFPVFGFGVIFGAIWAEEAWGRYWGWDPKETVSFIAWVVYAAYLHARSTAGWRDRKAAWINVVGFVAMVFNLFFINLVTVGLHSYAGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNI2</accession>
    <name>A0A132PNI2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-succinylbenzoic acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.26" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02810"/>
    <dbReference type="EnsemblBacteria" id="KWX23853">
        <property type="protein sequence ID" value="KWX23853"/>
        <property type="gene ID" value="AFM11_12550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6600"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008756">
        <property type="term" value="F:o-succinylbenzoate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="270"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="356" mass="36780" checksum="1FB7A7CEE991BFD4" modified="2016-06-08" version="1">MLAGRGSAILPLPADDERQTSLLTTALRIEEPIDDDVAVVVSTSGTTGAPKGAMLTREALTASAEATHRRLGGPGRWLLALPAYHVAGLQVLVRSVVAGNSPVTISPAFEPAELPSAVRALGTGRRYASLVAVQLDKALRDPAACAALAELDAVLIGGGPMPAGVAERAAAAGVTVVRTYGMSETAGGCVYDGVPLEGVVVRLEDSRIVLGGATIAKGYRNRVTPDPFAEPGWFRTDDLGAIDDSGVLRVLGRVDDAISTGGLTVLPQLVESALATHPAIAECAVFGVADERLGQRVVAAVVLTAGTEPPELTDLRAHVARTLDATAAPREIHVVDELPRRGIGKIDRRALAARFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNL9</accession>
    <name>A0A132PNL9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848097.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30695"/>
    <dbReference type="EnsemblBacteria" id="KWX23936">
        <property type="protein sequence ID" value="KWX23936"/>
        <property type="gene ID" value="AFM11_11200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6317"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453159" evidence="1">
        <location>
            <begin position="33"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="317" mass="33620" checksum="90993AE8278FFC8D" modified="2016-06-08" version="1">MPTTLSRRGFLAVTAGMALVAACGSQKPGEVAKDGSVTVRHIFGETKIPAPPQRVVSAGFTEQDDLLALGVVPIAVTDWFGGEPFAVWPWAQPKLAGAQPTVLSLADGVQVDQIAALKPDLIVATNAGLDADTYAKLSGIAPTIAQSGRDAFFEPWKDQATIIGQAVFKNDEMSGLIKGVEDKFAAVASSNPQFTGKKAVLLGGTMYRDSLQARPPGWRTEFLTQMGLTAPDVPALIPRDQWASVLDTADVLIWTTESDQERDALLADPTIAQLKATVGNRNVFTTKELAGAIAFASPLSYPVVADQLPPLLSRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNW5</accession>
    <name>A0A132PNW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma24 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_11345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848181.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30550"/>
    <dbReference type="EnsemblBacteria" id="KWX23964">
        <property type="protein sequence ID" value="KWX23964"/>
        <property type="gene ID" value="AFM11_11345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6346"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="383" mass="41905" checksum="02C7A7852D703A73" modified="2016-06-08" version="1">MTAVDDARLRDQIPAVLATLVRRGADFATAEDAVQEALVRAVRTWPDQPPDDPKAWLITTAWHCFVDLVRSDVARRRREDQVAYEPPPGPTVAVDDTLALYFLCAHPSLSPASAVALTLRAVGGLTTRQIAQAYLVPESTMAQRISRAKRTVSEVRLDQPGDLRTVLKVLYLVFNEGYSGDVDLAAEAIRLARQLAAGTDHPEVAGLLALFLLHHARRAARTRADGSLVPLAEQDRSLWRRDLIAEGVDVLQRALARDRLGEYQAQAAIAALHADAQHADETDWVQIVEWYDELVLLTDSPVVRLNRAVAVGEADGPQAGLAALAELDPALPRHTAAAAYLHERAGEFDTAVRLYVEAAAQADNVAERNHLTLKAATLRRHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPH1</accession>
    <name>A0A132PPH1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_09325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847039.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05900"/>
    <dbReference type="EnsemblBacteria" id="KWX24193">
        <property type="protein sequence ID" value="KWX24193"/>
        <property type="gene ID" value="AFM11_09325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5902"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="490" mass="51892" checksum="90AB9BA41CC2843F" modified="2016-06-08" version="1">MTTTDEPTTAGGRPLTTAESTGLERDALGPWGVFAQGLAAAAPSVAVAVVPFSLFVAAGKGAAWAAVIGLLIVVLVAITISFQAKRTVSSGSLGTYTGNGLGPGFAYAAGFSLLFGYIGFATTGTLGGVLYLDAFLESIGLGSQAVWFRLLLVLVVVGLAVYLPYRGVSVAARYELAFELLAIASILVIIVASYIGYGFRVDWEQWNPQHLGSSATFIAAVTAVGSYAGFESVASLGAEARNAHRNIARSLLRVVILLGVLYIFATYPQILHFGEIDGDKAVLPQLADSVGVAWVNQVVSAAVAVAFIVFVTAVTTAAARSLFTFAHEGALPQVFAKVHATYKTPWAGVVFVGVLALVFSTVATFSSAGRLVFDVYGGYVANWGFLVSYLLVVIATPIWLRKINALTPVRLAVSVAATIGLGYVIISNFYPVPEFPFNILPFVFGGILLIGLAWYWYLKRTRPEVARRIGSIQTLSEEEQQRLLNEGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPI2</accession>
    <name>A0A132PPI2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09590</name>
        <name evidence="2" type="ORF">AWC31_05635</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847198.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05635"/>
    <dbReference type="EnsemblBacteria" id="KWX24241">
        <property type="protein sequence ID" value="KWX24241"/>
        <property type="gene ID" value="AFM11_09590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09707">
        <property type="protein sequence ID" value="ORX09707"/>
        <property type="gene ID" value="AWC31_05635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5955"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009282">
        <property type="entry name" value="DUF937"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06078">
        <property type="entry name" value="DUF937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX09707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="205" mass="19632" checksum="F7E27134B3C4EA0B" modified="2016-06-08" version="1">MAGLDELFAQIPVADIANKLGADEGEVNAAIKTLVPALVGGVAENVKADNIDSSDLESTVTAKGASGLLDGGVSVDQVDAKEGDQIVAKIFGGNDSNQVASALAGTGAGGGDLIKKLLPILAPIVLAYIGKQFSQQNAPAQSAPQPQASGGGLGDILGSILGGAAGGSGGGNNPLGSILGSVLGGGGGQNNAIGEILGGLLGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPM3</accession>
    <name>A0A132PPM3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09505</name>
        <name evidence="3" type="ORF">AWC31_05720</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847139.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05720"/>
    <dbReference type="EnsemblBacteria" id="KWX24224">
        <property type="protein sequence ID" value="KWX24224"/>
        <property type="gene ID" value="AFM11_09505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09724">
        <property type="protein sequence ID" value="ORX09724"/>
        <property type="gene ID" value="AWC31_05720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5938"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="109" mass="11755" checksum="D7BF248AD5D2FE51" modified="2016-06-08" version="1">METVINGTALSRFGYALSDPTRARILLMLRDGPRYPSDLADAIGVSRQTLSNHLACLRGCGLVVVQPEGRRNRYELADRRIGHALDDLVGLVLAVDPACCPTADTEGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPQ1</accession>
    <name>A0A132PPQ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-myo-inositol dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847288.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05445"/>
    <dbReference type="EnsemblBacteria" id="KWX24273">
        <property type="protein sequence ID" value="KWX24273"/>
        <property type="gene ID" value="AFM11_09780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5994"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="305" mass="33748" checksum="5121260591FB65CD" modified="2016-06-08" version="1">MSTILVGSAPDSWGVWFPDDPQQTPYTRFLDEVAASGYEWIELGPYGYLPTDPERLADELAARNLKLSAGTVFEHLHQDDSWSAVWKQIEDVAKLTAAVGGKHVVVIPEMWRDPATGAVLEDRNLTPEQWKKKTQGMNNLGKAMFEKYGVRAQYHPHADSHVDTEENVYRFLDGTDGEFVNLCLDTGHISYCGGDNIAIIERAPERIGYLHLKQVDPEVRAKVEAEDLPFGEAVKLGAMTEPPRGIPDMPPLLAAVEKLGIDVFAIVEQDMYPCDVDAPLPIAKRTRAYLGSCGVPSVKFGLPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ24</accession>
    <name>A0A132PQ24_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10770</name>
        <name evidence="4" type="ORF">AWC31_19285</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX16982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847789.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19285"/>
    <dbReference type="EnsemblBacteria" id="KWX24431">
        <property type="protein sequence ID" value="KWX24431"/>
        <property type="gene ID" value="AFM11_10770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16982">
        <property type="protein sequence ID" value="ORX16982"/>
        <property type="gene ID" value="AWC31_19285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6193"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="82"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX16982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="431" mass="48401" checksum="7D17D02F3FBACE94" modified="2016-06-08" version="1">MQKDDMILISVDDHIIEPPNMFKNHLPAKYRDEAPRLVHNPDGSDTWQFRDTVIPNVALNAVAGRPKEEYGLEPQGLDEIRKGCYDPDERVKDMNAGGVLATMNFPSFPGFAARLFATEDAEFSLALVQAYNDWHIDEWCGSNPGRFIPMAIPAIWDPQLCADEVRRVSKKGVHSLTFTENPSTLGYPSFHDLEYWKPLWEALVETDTVMNVHIGSSGKLAITAPDAPMDVMITLQPMNIVQAAADLLWSAPIKAYPDLKIALSEGGTGWIPYFLDRVDRTYEMHSTWTHQDFGGKLPSDVFREHFMTCFISDPVGVKNRHLIGIDNICWEMDYPHSDSMWPGAPEELWAVFDTYDVPADEINKITHENAMRLYHFDPFKDVPKDQATVGALRKSAEGHDVSIRALSNKEKTGTSFADFQANAKAVSGAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ66</accession>
    <name>A0A132PQ66_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05605"/>
    <dbReference type="EnsemblBacteria" id="KWX24476">
        <property type="protein sequence ID" value="KWX24476"/>
        <property type="gene ID" value="AFM11_09620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5961"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="DUF3445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="DUF3445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="339" mass="38180" checksum="E23FD476963F659A" modified="2016-06-08" version="1">MTPVLVSAPDLLATFPFPFPSDRYRYSTNVEPAGGAVVTPVGRWGDRVVDIDSEYEHELAQRARILAADPTRYAVLPHMRAACWDAMLVLMREMATSYPDIMSLTTNGSVWHWRNNRLGIAQDFVAGDESSLPAEPLAYIAGQVQDDIVLLDQRDDDLFGDAGVVTFAADWSFGFDVGMTFLEIHGPVPRLRQTGVITRAREFLMRLQPNETYRRTNWTLTIGRRLDVSTELYHEWGPDRPMIGTVDDETFGRLVHLRVELQHLIRLPESGAICFLIRTYMLPLADLVTVAPWRDRLAAVLSDLPDDMADYKGIIGYRDRVVAWLAAHQAAQQNTPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQH5</accession>
    <name>A0A132PQH5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metal ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_07670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846064.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22165"/>
    <dbReference type="EnsemblBacteria" id="KWX24555">
        <property type="protein sequence ID" value="KWX24555"/>
        <property type="gene ID" value="AFM11_07670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5383"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="791" mass="83895" checksum="CB9AB065069C3EEA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR16</accession>
    <name>A0A132PR16_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10360</name>
        <name evidence="3" type="ORF">AWC31_18790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX16901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847584.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18790"/>
    <dbReference type="EnsemblBacteria" id="KWX24492">
        <property type="protein sequence ID" value="KWX24492"/>
        <property type="gene ID" value="AFM11_10360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16901">
        <property type="protein sequence ID" value="ORX16901"/>
        <property type="gene ID" value="AWC31_18790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6109"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="74" mass="8032" checksum="28C60851EABA6BA5" modified="2016-06-08" version="1">MANRDPETIKQEIDKARDQLALTVDSLAERANPQRLADDVKAAVIRFVKKPVVAASLAGVGALVVVVAIRRVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRF2</accession>
    <name>A0A132PRF2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1,2-oxophytodienoate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846948.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00145"/>
    <dbReference type="EnsemblBacteria" id="KWX24844">
        <property type="protein sequence ID" value="KWX24844"/>
        <property type="gene ID" value="AFM11_08215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5494"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="10"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="367" mass="39080" checksum="4E1FF67787E9C2EF" modified="2016-06-08" version="1">MFRLDADAALLQPIQVGDTAATNRLFMAPLTRSRADADGTPSPLAAEYYAQRASAGIIISEATAIAETANGAYMNTPGIYTDRHQAGWAEIADAVHTAGGKMFVQLWHVGRLAHPEISGAESVAPSAIAADMLSHTPTGKKPLETPRALRTDELPGIVDQFRAAARRAIDAGMDGVEIHAANGYLLHQFQSDVINQRTDAYGGSPENRARLTVEVVEAVVAEIGAGRVGVRISPGNRAGDMHENDTVSVYEALLNRIAPLNIAYLHLLIDPSAHTFGVIRALWPGTFVLNTGRNTGTDFSQLESYAEWGAISAAAVGRTYLANPDLIDRLILGAELNEPDVATFYAPGPVGYIDYPTLAEVAEPKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRH4</accession>
    <name>A0A132PRH4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13310"/>
    <dbReference type="EnsemblBacteria" id="KWX24864">
        <property type="protein sequence ID" value="KWX24864"/>
        <property type="gene ID" value="AFM11_09060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="115"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="227" mass="24261" checksum="0679133B2399C303" modified="2016-06-08" version="1">MAALVGCSWTRTGRVEPGRVLPDGCMDLIRSGDQTIVAGPDTTAYLAAGSPHPIQGLRFRPGVLPRLLDVPAAEVQNIRVPLHDLRTVRRDRSLYELTADLASGRPGTTTAPWSLPTLREVTNRLADGAAVGDIAHATGWSTRTLQRQCAAVYGYGPAMLRRVLRFRRAVRLLSAGLPAADVAAQAGYADQPHLHREVRDLAGVPLRQLASGAYRSTDVPSGSSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRJ4</accession>
    <name>A0A132PRJ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845034.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12965"/>
    <dbReference type="EnsemblBacteria" id="KWX24915">
        <property type="protein sequence ID" value="KWX24915"/>
        <property type="gene ID" value="AFM11_05590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4308"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="298" mass="32081" checksum="31331C32F4F3A319" modified="2016-06-08" version="1">MTTESAEAPVESTPWTLQMLLDLFDAEPAGDDRFIAQTGIAGTDERQVVEGTQILAAAIVAVAKRFPEKSVRTAHAVFARAVMVGPPVELDIDVISEGRSTATAVVAASQNGKRCITITVFTDVPSGDVIRHHLPRPDVAAPADANVSPMPMTGRQLRLVDVVDVNSPDEVGPPELYAWLHYDPIPTRDDLAKALIAYFTGHLGISTTMRAHEGIGTAQAHVTVSTAPMTVTVSFHEPVRWDGWILYSHESTQVGSGMSYVRGAVHTEEGELIASFSQDALIRPLRTTDTNISAHSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRR5</accession>
    <name>A0A132PRR5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine desulfurase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Fe-S cluster assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ORF">AFM11_06360</name>
        <name evidence="7" type="ORF">AWC31_29315</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845276.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29315"/>
    <dbReference type="EnsemblBacteria" id="KWX25048">
        <property type="protein sequence ID" value="KWX25048"/>
        <property type="gene ID" value="AFM11_06360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13877">
        <property type="protein sequence ID" value="ORX13877"/>
        <property type="gene ID" value="AWC31_29315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4466"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX13877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="255" mass="27545" checksum="1DD4BD91CE9B2077" modified="2016-06-08" version="1">MSTLEIKDLHVSVASAEDGTDIPILKGVDLTVNSGETHALMGPNGSGKSTLSYAVAGHPKYTVTSGSITLDGQDVLEMSIDERARAGLFLAMQYPVEVPGVSMSNFLRTAATAVRGEAPKLRHWVKEVKAAMDDLDIDPAFGERSVNEGFSGGEKKRHEILQLSLLKPKIAILDETDSGLDVDALRVVSEGVNRYAEDTHGGILLITHYTRILRYIRPQFVHVFVGGRIVESGGPELADELEENGYVRFTQAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRT2</accession>
    <name>A0A132PRT2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845831.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29555"/>
    <dbReference type="EnsemblBacteria" id="KWX25005">
        <property type="protein sequence ID" value="KWX25005"/>
        <property type="gene ID" value="AFM11_06120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4416"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="398"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="453" mass="48796" checksum="A5976C722BA698B1" modified="2016-06-08" version="1">MERVFTTVIDAPRDDVFSWHARPGAFERLSPPWQPVRIVSEAESLADGRARLALPGGLRWVARHRPELYDPPRCFVDSISSDGIASLPVRVVARWTHTHEFEDAGDGRTRMIDRVETPVPAVALHAMFAYRHRQLAADLAAHRAAGERGLGSVTVAITGSSGLVGSALSAFLTTGGHRVIKLVRHPAANTDERQWNPADPEPELLSGVDALIHLAGASIAGRFTAEHKRAIRESRVGPTRRLAELAARTADGPATMVCASAIGFYGNDTGENPVSEDSERGDGLLAEVVADWEAATAPAAAGGLRVVQVRTGIVQSPRGGVLRALYPLFALGLGGRIGDGTQWLSWIGIDDLLDVYHRALWDDGLSGPVNAVAPEAVRNTDYTRTLARVLRRPALLPVPALGPKLLLGDEGARELACASQRVVPVRLERAGHRFRHATLEDGLRHVLGRTRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRV0</accession>
    <name>A0A132PRV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_06515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845332.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29160"/>
    <dbReference type="EnsemblBacteria" id="KWX25071">
        <property type="protein sequence ID" value="KWX25071"/>
        <property type="gene ID" value="AFM11_06515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4497"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="349"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="481" mass="50250" checksum="583FF676C149F627" modified="2016-06-08" version="1">MRRTARGPRTRGADRTSPSRLYARIFAVPLTLGMLLATALSGGGPAVADPGGSDLATLVAAVANADQKLQELGAAIQTQQETVNKAILDVQTARDGAAAAQREVEASQQGIADANAAIEAAQKRFDTFAAATYVNGPSSSYLTAADPGDMVSTAATGQALAASADQVIADLQRARTEQVNRESTARLAKQKADQATIDAQTSQDSAVSALKQAQQTFSTQQGELQRLTAERAAAQRQLDQVRTVSAASGAPARAPQPAPQAAAGDWDRAPGAPVQAGQNWDTAWDPTLPAIPSAFVSGDPIAIINAILGISQTSAQVTANMGRTFLQKLGILPTPSGFTNGAIPRVYGRQAMEYVIRRGMSQMGVPYSWGGGNAAGPSRGIDSGAGTVGFDCSGLMLYMFAGVGIKLDHYSGSQYNAGRKVPSSQMRRGDMIFYGPNASQHVAMYLGNGQMLEAPYTGSHVKISPVRTSGMTPYVTRLIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRV3</accession>
    <name>A0A132PRV3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase A</fullName>
            <ecNumber evidence="6">4.2.1.3</ecNumber>
            <ecNumber evidence="7">4.2.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">(2R,3S)-2-methylisocitrate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Iron-responsive protein-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Probable 2-methyl-cis-aconitate hydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">acnA</name>
        <name evidence="20" type="ORF">AFM11_06505</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="6"/>
    <dbReference type="EC" id="4.2.1.99" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845328.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29170"/>
    <dbReference type="EnsemblBacteria" id="KWX25069">
        <property type="protein sequence ID" value="KWX25069"/>
        <property type="gene ID" value="AFM11_06505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4494"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="20" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="18">
        <location>
            <begin position="72"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="19">
        <location>
            <begin position="734"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KWX25069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="942" mass="102327" checksum="53050A9AE4C7CA83" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS32</accession>
    <name>A0A132PS32_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Histidinol dehydrogenase</fullName>
            <shortName evidence="10">HDH</shortName>
            <ecNumber evidence="5 10">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisD</name>
        <name evidence="17" type="ORF">AFM11_06860</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11 16">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5 10"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845473.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28790"/>
    <dbReference type="EnsemblBacteria" id="KWX25133">
        <property type="protein sequence ID" value="KWX25133"/>
        <property type="gene ID" value="AFM11_06860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4571"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KWX25133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="442" mass="45921" checksum="1B80105757140B37" modified="2016-06-08" version="1">MAEFQMSRIDLRNRALNAAQLRVALPRGGVDVDAVVPKVRPIVEAVAQRGAAAALEYGESFDGVRPDTVRVPAAALTQALAELDPAVRTALQVSIDRARAVHADQRRTDTTTTLAPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGVDSLVIASPPQAQFGGLPHPTILAAAALLGVDDVWAVGGAQAVALLAYGGTDTDGTELAPVDMITGPGNIYVTAAKRICRSQVGIDAEAGPTEIAILADHTADPVHVAADLISQAEHDEMAASVLVTDSVALAEATDRELANQLATTVHVERVTAALTGKQSATVLVDDIEAGIRTVNAYAAEHLEIQTADAAGVAGRIRSAGAIFVGAWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYDEAALKDVSGHVITLSKAEDLPAHGEAVRRRFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSA9</accession>
    <name>A0A132PSA9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845518.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28680"/>
    <dbReference type="EnsemblBacteria" id="KWX25154">
        <property type="protein sequence ID" value="KWX25154"/>
        <property type="gene ID" value="AFM11_06970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4593"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="137" mass="14380" checksum="C3763A771BA61309" modified="2016-06-08" version="1">MEPSSAFGTKSARYGALGAGAVLVGGLAYIGLGDPHRPGFLFPPCPFKALTGWDCPACGGLRMTHDLLHGDIGAAVVDNVFLLVGLPLLAVWIVARWRMGRRPFPAPAVVVLVLAIVAWTVVRNVPGFPLVPTVIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSE6</accession>
    <name>A0A132PSE6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843796.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25278">
        <property type="protein sequence ID" value="KWX25278"/>
        <property type="gene ID" value="AFM11_02990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2466"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="103" mass="9881" checksum="CA4DCA3D096BA132" modified="2016-06-08" version="1">MSVDGVGADGVGIGSLEGVLGGADVGGLAVDIAGGVGAGSTMTTRGLVSPVSSTAMMRAPVTSTNPIVPMAVMTMSLERDHALSMRTLMGAVAASASSASTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSN0</accession>
    <name>A0A132PSN0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844033.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21685"/>
    <dbReference type="EnsemblBacteria" id="KWX25349">
        <property type="protein sequence ID" value="KWX25349"/>
        <property type="gene ID" value="AFM11_03465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2567"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="376" mass="38845" checksum="636B113E55589644" modified="2016-06-08" version="1">MSTVGDVFALIRRRRDITRTEIGQVTGLSRTAVSARVASLAAQGLVVESEQAPSTGGRPATLLSFNADAGVVLSAAIGRSRTRLAVCNLAGDVLDLTDIDQQPELGPDDLMPDVVKRLDALLASHRGAHVYGIGASLPGTVDRARGASLDSPILPGWDGVELQTYFRELTHAPVVVDNDVNVIAIAEKHSAVDDMLVLKASTGIGTGIIAGGALQRGAMNAAGELGHNKTPAAAGLPCRCGDTGCLEAIAGGWALVTALRQDGKPVSHLRDVVVLAHSGDADARRMIRDSGRHVGEVLAAAVNLLNPAVLVVAGDMSGGYDIFVAGLRETLYGNATALATRTLQVVPSTHGDRSGVIGCATMILDEVLSADAIDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSV2</accession>
    <name>A0A132PSV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844289.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21205"/>
    <dbReference type="EnsemblBacteria" id="KWX25426">
        <property type="protein sequence ID" value="KWX25426"/>
        <property type="gene ID" value="AFM11_03960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2670"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="1">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="270" mass="28572" checksum="0C629FAFD4AC985E" modified="2016-06-08" version="1">MRPQLNKDTKVCISLAARPSNIGTRFHNYLYEQLGLDFLYKAFTTTDIAAAIGGVRALGIRGCSVSMPFKQDVMRLVDDIEPSARAIDAVNTIVNDDGHLTASNTDYVAVQTLIDGLDPSDAVIIRGSGGMANAVGTAFRDKGFRSGVIVARNRQAGPALAERLGYDYAAEVGDLTAPVVVNVTPIGMADGPDEHRCAFGADTIEAAHTVFDVVAMPAETPLISAARAAGRRVITGAEVIALQAAEQFERYTGVRPTAEQVAAASEFSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSW5</accession>
    <name>A0A132PSW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_06795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845457.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28855"/>
    <dbReference type="EnsemblBacteria" id="KWX25122">
        <property type="protein sequence ID" value="KWX25122"/>
        <property type="gene ID" value="AFM11_06795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4558"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="8">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="21393" checksum="70F5420832AB624A" modified="2016-06-08" version="1">MQLHKPDVVAAATAILDNYGIGDLTMRRLARELGVSPGALYWHFANKQELLGAVADHILQPARVDAAGLGWRDRVQAICTTLRDALLSHTDGAELVSSSFAAGQSATAAGIVAQLTDAAHEAGVAVDDAELAARTVIYYVLGFTVDEQSRLQWDAAGALTDEQSVFVRDANRQFAFGLRLLVDGLGVQGGTEADVIERSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT11</accession>
    <name>A0A132PT11_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_03830</name>
        <name evidence="6" type="ORF">AWC31_21335</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844218.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21335"/>
    <dbReference type="EnsemblBacteria" id="KWX25404">
        <property type="protein sequence ID" value="KWX25404"/>
        <property type="gene ID" value="AFM11_03830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16573">
        <property type="protein sequence ID" value="ORX16573"/>
        <property type="gene ID" value="AWC31_21335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2642"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX16573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="228" mass="25615" checksum="58DACD1746DD298B" modified="2016-06-08" version="1">MRILVVDDDRAVRESLRRSLSFNGYSVELAQDGVEALDLIANDRPDAVVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTVSDDGADSQIMSFSDLTLDPVTREVTRGQRQISLTRTEFSLLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYIGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT49</accession>
    <name>A0A132PT49_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25490">
        <property type="protein sequence ID" value="KWX25490"/>
        <property type="gene ID" value="AFM11_04385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2753"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="807" mass="85780" checksum="165F145BCBE99106" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT63</accession>
    <name>A0A132PT63_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25495">
        <property type="protein sequence ID" value="KWX25495"/>
        <property type="gene ID" value="AFM11_04410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2758"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="247" mass="26311" checksum="37D6B764009DFE3A" modified="2016-06-08" version="1">MSDDTHVSAEANVTNVEPAVETSAEQQAEPAPSNQQRTWSMPKPPISRKQVDDIGRRMLKAMAGVAGFVATAARYGAISVAKMWRRFEAVPTAGKLSSLTLLALLLGISGAIALDNALGVLCTVAVVPVCAGILGALGHRWYSRLGEETAQRTDARPAEPADSELQKSVEYVDRKLTLALTSFGTEHHQQAVIALFQAKTAVELTLGTEQDLASYGDIALRPDDYGLRPRIRGGSTSTPREGNSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTB7</accession>
    <name>A0A132PTB7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844622.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20375"/>
    <dbReference type="EnsemblBacteria" id="KWX25555">
        <property type="protein sequence ID" value="KWX25555"/>
        <property type="gene ID" value="AFM11_04770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2835"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="63"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="31191" checksum="7D6F77AA34BC943E" modified="2016-06-08" version="1">MLASTGSAYIGARNLLSGQADKARQVIPKSWDIPPRADGVYSPGGGPVERWERGVPFDVYLMIFGDSTATGYGCHVADEVPGVLLARGVAEQLGKRIRLSTKAIVGATSKGLSGQIDAMFVAGPPPDAAVIMIGANDITRPNGIGASARRLGAAVRRLRSAGAVVVVGTCPDFGVITAIPQPLRWYTRGRGLRLARAQAGAVRAAGGVPVPFSDLLAPEFYKAPELLFSEDMFHPSAAGYALAAKQLLPALCNALGEWDGDAALETGAADTSTLLTRLGSMSRLWRRSTGVPAPVVVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTC5</accession>
    <name>A0A132PTC5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844641.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20320"/>
    <dbReference type="EnsemblBacteria" id="KWX25565">
        <property type="protein sequence ID" value="KWX25565"/>
        <property type="gene ID" value="AFM11_04825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2846"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="657" mass="69731" checksum="6DADF573769BD7F3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTF4</accession>
    <name>A0A132PTF4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844717.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20200"/>
    <dbReference type="EnsemblBacteria" id="KWX25600">
        <property type="protein sequence ID" value="KWX25600"/>
        <property type="gene ID" value="AFM11_05030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2887"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="31"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="267" mass="28108" checksum="698E5EBE61C87304" modified="2016-06-08" version="1">MTAAPEADLTGWTAAPFTAAGQTHDVYRKGEGPGVVLIPEMPGLHPGVLALGNHLVDNGFTVAAPSLFGTPGAPALRPGMVPVLVKGCVTREFAAFATNADRPVAHYLRALARDLNASTPGRGVGVIGQCFTGGFALAAAVDDSVLAPVLSQPSLPLPLTPKHKRDPGLSEAELKIVEQRAANDGLCALGLRFSQDWMAPGERFTTLKARLGDAFEVIEINSMKGNEHGILPSAHSVLTDQVREVDGHPAYEARKRVVEFLTERLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTP8</accession>
    <name>A0A132PTP8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844277.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21225"/>
    <dbReference type="EnsemblBacteria" id="KWX25422">
        <property type="protein sequence ID" value="KWX25422"/>
        <property type="gene ID" value="AFM11_03940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2666"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="270" mass="29284" checksum="C7413986982EC0D7" modified="2016-06-08" version="1">METMGPFGIAVDVGAEYLETAPEIEALGFGTLWVNGGQLDRLDRLRELIEATSRAVVAPAVVMPDGYRPGELGEFYRQVEARTPGRLVMGLGPLAGAHASSRLAQYFGDPEFSIPPNRRLLAAFGPSRLALAREYCAGAVPMLFTPQGTAAARRRLGQDRILALGQYVVMDENPETARDTARVPLRFLFSMPSYVNSALRQGFTEDDVNSLSDRLVDSLVAWGTSGQIAERLREQRIAGADHVYATVLHDGQQPGVLDAARALGPLLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTT2</accession>
    <name>A0A132PTT2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33275"/>
    <dbReference type="EnsemblBacteria" id="KWX25751">
        <property type="protein sequence ID" value="KWX25751"/>
        <property type="gene ID" value="AFM11_00165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.34"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011200">
        <property type="entry name" value="UCP012608"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10094">
        <property type="entry name" value="DUF2332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012608">
        <property type="entry name" value="UCP012608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="347" mass="37741" checksum="A01C1A5FBD689470" modified="2016-06-08" version="1">MSDRLLGAFDVQARACAALGSPMYAELLDLVLDDIRSRGIFADVLAGHEDDPGPSGLALRLLGGLHRLVLDGRAPALAAWYPSVGGRWDAAAAWPEILATARRQTAYLRAMLDQPPQTNEVGRSAALIGGLLHLVDRFPLPVKLFEIGSSAGLNLRADHYLYRHAGGQWGPADSAVVIEDAWHGALPPAAPLRIAHRHGFDIAPVDARTEDGRLTLLSYVWPDMTARLHRLSGAIDIARRVDADLDRMPAAEAVSRLQLTPGTLTVLWHSVTWQYLGAAEQHAVETRLKALGSAATANTPFAWLNLEPQRRAPDAHHEFLIRVRCWPDGADRILGSCAPHGPPVHWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTV1</accession>
    <name>A0A132PTV1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine deiminase</fullName>
            <shortName evidence="3">ADI</shortName>
            <ecNumber evidence="3">3.5.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arginine dihydrolase</fullName>
            <shortName evidence="3">AD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arcA</name>
        <name evidence="5" type="ORF">AFM11_00110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-arginine = L-citrulline + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="EC" id="3.5.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the arginine deiminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842063.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33220"/>
    <dbReference type="EnsemblBacteria" id="KWX25743">
        <property type="protein sequence ID" value="KWX25743"/>
        <property type="gene ID" value="AFM11_00110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.23"/>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00242">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01078">
        <property type="entry name" value="arcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3 4">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="415" mass="45965" checksum="002FD4AA14C284CF" modified="2016-06-08" version="1">MTNLSDTYGVHSEVGKLRKVLVCSPGLAHERLTPTNCDDLLFDDVLWVQNARRDHFDFMDKMRDRDVEVVELHNLLTETMDIPEAKAWLLDRKIVANEVGLGLVDDTRAFLDSLTSRRLTELLIGGMSIRDLPAEMQSGYRALAREATGVTEYLMPPLPNTLYTRDTTCWIYGGLTLNPLFWPARHDETLLMKTIYEFHPDYIGSTVWWGDPEESWGLSTIEGGDVMVPGNGVVLIGMSERTSRQAITQVAAELFAAEAAEKVIVAGMPKLRSAMHLDTVFTFADRDVVTIYPGIVDSIEPFILHPSDTAPGVEVEEATKPFVETVADSLGLSKLRVVETGGTAYDSERQQWDSGNNLVAVEPGVVFAYDRNTHTNSLLRKAGVEVITIVGAELGRGRGGGHCMTCPIIRDPLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTW0</accession>
    <name>A0A132PTW0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="13" type="ORF">AFM11_00270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842158.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33380"/>
    <dbReference type="EnsemblBacteria" id="KWX25771">
        <property type="protein sequence ID" value="KWX25771"/>
        <property type="gene ID" value="AFM11_00270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.55"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="110"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX25771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="154" mass="16448" checksum="CF60B1C446DFBDA1" modified="2016-06-08" version="1">MTTTIEYPSATAKARFVRVSASKARRVIDLVRGKSVEEALDILRWAPQAASEPVAKVIASAAANAQNNEGLDPSTLVVATVYADEGPTAKRIRPRAQGRAFRIRKRTSHITVIVESRPPKQKGAAAQSARSRRAQGSKAAAKKTTTPETKGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTZ3</accession>
    <name>A0A132PTZ3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_03415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21735"/>
    <dbReference type="EnsemblBacteria" id="KWX25667">
        <property type="protein sequence ID" value="KWX25667"/>
        <property type="gene ID" value="AFM11_03415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2557"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="101"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="162"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="397" mass="42699" checksum="7FA0E53C005B9B7E" modified="2016-06-08" version="1">MAITTSAWLFALSALILLGVYFALSRTIDAAPLDAVTVKRFERKPDGTMVYRPGENFQAADLRSVQQAVNQSTLDLLRNYSLIALAAIFVICLLVGWIVAGRLLRPIGQITATANRLRATDLSQRIGATGPHDELRALADTLDGMLDRLDSAFRAERALVEDVSHELRNPVAVVQANVEAVLANPDATPAEREHALVVISRATARMSRLLEDLLATARRRSGSFADRNVDLHGFIGDVVDEHSLLAAERPLAVVARSSPGPVVYADPESLGRAVANLLSNAIRLAPTDSIVTVAGGSTRGWAWIAVQDDGPGIADDEQPHVFDRFKRASNGDNGSRRGSGLGLAIARQIVESHEGRITLFSRLGEGSTFVIWLPDRAVADGPERAAAPPSECPLPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU22</accession>
    <name>A0A132PU22_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fluoroquinolone transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842344.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33745"/>
    <dbReference type="EnsemblBacteria" id="KWX25836">
        <property type="protein sequence ID" value="KWX25836"/>
        <property type="gene ID" value="AFM11_00635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.130"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="253" mass="27098" checksum="2FD37BA47CD8359A" modified="2016-06-08" version="1">MTASFLPAAGRALAAFGRNDIRGTYRDPLLVMLVLAPVIWTSGVALLTPMFTDMLAQRYDFDLVPYYPLILTAFLLLTSIIIPGGLGAFLVLDEVDAGTMTALRVTPVPMSTFFAYRAVTVMVVTTVYVVATLSLSGILAPGLVGVLIPIGMLAGLSAIVTLLAIIAVANNKIQGIAMVRALGMLIAGLPCLPWFIDSAWNLAFGVLPPYWAAKAFWVASAGGVWWPYLLGGVVYNVAIAWPLFRRFLAKTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU44</accession>
    <name>A0A132PU44_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842411.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33805"/>
    <dbReference type="EnsemblBacteria" id="KWX25858">
        <property type="protein sequence ID" value="KWX25858"/>
        <property type="gene ID" value="AFM11_00765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.157"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="30985" checksum="6C82277803C4C878" modified="2016-06-08" version="1">MTEALSLKPDLGHYGVWTLGAVKPEQAAEIEKLGYGAVWIGGSPAADLASVEPILDNTENLQVATGIVNIWTADANQVAESFHRIEASHPGRFLLGVGVGHPEHTDEYRKPYDALVEYLDVLDAAKVPTSRLVLAALGDKVLKLSARRSAGAHPYLTTPEHTEHARDVLGETVFLAPEHKVVLTTDSAEARKIGRDTVDFYLNLSNYLNNFKRLGFTEKDIAKPGSDKLIDAVVAHGTAGDIAARLRQHIAAGADHVTIQVLGGWDKLIPTLTELAGPLGLNEDLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU59</accession>
    <name>A0A132PU59_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="12" type="ORF">AFM11_00465</name>
        <name evidence="13" type="ORF">AWC31_33580</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33580"/>
    <dbReference type="EnsemblBacteria" id="KWX25804">
        <property type="protein sequence ID" value="KWX25804"/>
        <property type="gene ID" value="AFM11_00465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11618">
        <property type="protein sequence ID" value="ORX11618"/>
        <property type="gene ID" value="AWC31_33580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.94"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX25804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX11618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="216" mass="22088" checksum="B49ACA1AD1D6AB8C" modified="2016-06-08" version="1">MMAEQAGAAQASEGRGGRGRRDDRGGRGGRDSGEKSNYIERVVSINRVSKVVKGGRRFSFTALVIVGDGKGMVGVGYGKAKEVPAAIAKGVEEARKNFFRVPLIGGTVTHPVQGEAAAGVVMLRPASPGTGVIAGGACRAVLECAGVHDVLAKSLGSDNAINVVHATVAALKLLQRPEEVAARRGLPIEDVAPAGMLKARRESEALAAAAAREGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUC4</accession>
    <name>A0A132PUC4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842607.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34165"/>
    <dbReference type="EnsemblBacteria" id="KWX25920">
        <property type="protein sequence ID" value="KWX25920"/>
        <property type="gene ID" value="AFM11_01125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.231"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024029">
        <property type="entry name" value="Pyridox_Oxase_FMN-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04025">
        <property type="entry name" value="PPOX_FMN_DR2398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="45"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="223" mass="24149" checksum="55663D690F7DB12B" modified="2016-06-08" version="1">MKSTDTTAADGYAPITMERVREIVGFPERFIAEKKEAKLGEFSARFIAHSPFFCMSTVGADGQLDTSPRGDPPGSVRILDPWTLAIPDRPGNKLADTHENITSHPAVGLVFFVPGLREVIRVNGDAFVTDDPELLDMLSADGKPAVLATIVRIREVFGQCGKAVIRAKLWEGDSRGLAEAVTLGGDFYTLTITESAAKMAEKLGDLAGSLHAVIDDHYENDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUE5</accession>
    <name>A0A132PUE5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842648.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34255"/>
    <dbReference type="EnsemblBacteria" id="KWX25933">
        <property type="protein sequence ID" value="KWX25933"/>
        <property type="gene ID" value="AFM11_01220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.250"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="263" mass="26909" checksum="CAD215330A705242" modified="2016-06-08" version="1">MTATGQAAAVLANAAFGDDPGRWPLPTATSPEDRWLRGVAAGGQGRYACALAELAELSRTASGPLLSLAYSTRASFLRQTGWHTRARGADGMALAHCGQDPEAASDALVGLAADALGVGRFGVSARLLERAHLIDAPRARTAVRLAWVSAELAMARGDGAAAVGHAERGVLAAADCGSTRHAIKSDVVLAAALCSAGRLDAAREVADAALPAAEQSGMIPLRWALACLLAGIGSTAHTAAQVFEIRDVSADTVRRRGGVWSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUG7</accession>
    <name>A0A132PUG7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_01505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842809.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="9myco-a0a132pug7">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25976">
        <property type="protein sequence ID" value="KWX25976"/>
        <property type="gene ID" value="AFM11_01505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.308"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="444" mass="47577" checksum="B89FA8F5012CB73A" modified="2016-06-08" version="1">MHDEVLTTSGQWRGCRSGDVAVFRGIRYAQADRFGPPRPIPLAGSMFDATDRGPAAPQLPSRLEAIMGAPARYRQSPDCLRVTVTAPAGAEPGSRPVLVWLHGGAYLSGSGEWNLCDADHLVRQTDIVVVAVSYRVGAFGYLRAAGVSPGNLGLLDQITALEWVRDHIAEFGGDPSRVTVAGQSAGAQSVVAMLGIDRSRTLFDQVIIQSAPLGIAFHSPDQAQRVADVVLGELGTDPRETTDAEILDAQARAARRLAGRLGLNSAPPLRPVSGITPLPDEPEWRQTVIERAADLRVLIGTTADEMAAFYGPHPFFSALRRVPVIGKPIALIVQKAVQAKTFDKPTDQLADLLADAGAGVYRYRVGSLHPANPFGACHCIELPLLFGDGEAWKNAPMVSPLTAGEITAIGARTREHWGQFISTGEISGDWRMHRPGSRRVHALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVC2</accession>
    <name>A0A132PVC2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843741.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35200"/>
    <dbReference type="EnsemblBacteria" id="KWX26286">
        <property type="protein sequence ID" value="KWX26286"/>
        <property type="gene ID" value="AFM11_02420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.496"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="355" mass="38276" checksum="8050D1BE734F5F1D" modified="2016-06-08" version="1">MQAGPDHRSAGHYLRCTPENVCWGTLPTPDTARVLAVDSGATVTFDTVSQEGLMEDQGRDPVAYFGRHGVERADVLDDAVELAASDLRKPEPPKAPHIVLGPVDVRGAEPGDWLRVDFLDLRPRVPYGVVSSRHQRGALPDRLPRDFDGSSPAVFSKFCRLDDSGTRAVFEFCGGRATIAVRPFMGLCGVTPAGSEPLSTIPPGPFGGNMDVREIVSGSSLYLPVQVPDAGFYLGDPHFAQGNGEIALTALEGSLRVTARLTVVKTVSPARARMPFVETDDHWIILGMNESLDEAMRQCAGLSVDFLSAQTGMTPSESYLYLSAAGDFSVTQVVDIVKGVHCSIRKSDFREECRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVH7</accession>
    <name>A0A132PVH7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_02760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843428.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35535"/>
    <dbReference type="EnsemblBacteria" id="KWX26167">
        <property type="protein sequence ID" value="KWX26167"/>
        <property type="gene ID" value="AFM11_02760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.568"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="288"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="542" mass="58547" checksum="3C3B642C428D13F8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVT4</accession>
    <name>A0A132PVT4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_02575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26142">
        <property type="protein sequence ID" value="KWX26142"/>
        <property type="gene ID" value="AFM11_02575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.528"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="25"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX26142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="331" mass="36363" checksum="816DF1F82B06FE8D" modified="2016-06-08" version="1">MESITRRTTRDDERQTLMHELKRVLVTGGGGFLGGHLCERMLDEGLEVICVDDLSTSAPTAAGLLRDREGYQFVQHDISDPLTEIPAVDTIFHLASPASPVDYQRLPLQTLRTGALGTANALEVAERCGARLVLASTSEVYGDPLEHPQRESYWGNVNPVGPRSMYDEAKRFAEALTFSYQRARNADIGVARIFNTYGPRMRADDGRIVPTFCRQALAGEPITVHGSGRQTRSLCYVDDTVAGLLALARSDCAGPINIGNPHELTVLQIAELIRELAGSQSPVEFVAQGDDDPQRRCPDITAASEQLGWRPRVDCRRGLAMTLEWFAEQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAW9</accession>
    <name>A0A132PAW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000049">
        <property type="protein sequence ID" value="KWX19456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859969.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31620"/>
    <dbReference type="EnsemblBacteria" id="KWX19456">
        <property type="protein sequence ID" value="KWX19456"/>
        <property type="gene ID" value="AFM11_35790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5895"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="29"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="457"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="553" mass="59455" checksum="3DD699B72DFDABB9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAY7</accession>
    <name>A0A132PAY7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the non-flavoprotein flavin reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000046">
        <property type="protein sequence ID" value="KWX19480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859909.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31605"/>
    <dbReference type="EnsemblBacteria" id="KWX19480">
        <property type="protein sequence ID" value="KWX19480"/>
        <property type="gene ID" value="AFM11_35690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5873"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="173" mass="18321" checksum="8B69464A58A1C367" modified="2016-06-08" version="1">MTTLDPVLSGDSDRDVSKLRKLYGRYPTGVAAVCALRDGQPVGIVATSFTPVSIDPALVSICVQHTSTTWPLLAEGRHLGVSVLASRHEAACRQIASKNVDRFAGVSWFATETDAVLLRDAAAHLDCEISTSISAGDHDVVLLEVKAAATNEGVPPLVFHDSGFRMLAIGHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB31</accession>
    <name>A0A132PB31_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000044">
        <property type="protein sequence ID" value="KWX19520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026138108.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19520">
        <property type="protein sequence ID" value="KWX19520"/>
        <property type="gene ID" value="AFM11_35445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5822"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="129" mass="13644" checksum="FFD8AA60FBD913F8" modified="2016-06-08" version="1">MPRSTTAAVTAPGGETACTHLDATAKFFRALSDPTRLKLLEFILAAERTSAECVEHAGISQPRVSVHLSCLADCGYVTARRDGKKLRYSVGDPRVADLVMLARSLAADNAAALTCCTRIDTARVNGAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB69</accession>
    <name>A0A132PB69_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859665.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19573">
        <property type="protein sequence ID" value="KWX19573"/>
        <property type="gene ID" value="AFM11_35135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5755"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="344"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="608" mass="66146" checksum="EC99F81DC7AF6529" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB75</accession>
    <name>A0A132PB75_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000044">
        <property type="protein sequence ID" value="KWX19507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010596915.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19507">
        <property type="protein sequence ID" value="KWX19507"/>
        <property type="gene ID" value="AFM11_35450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5823"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="99" mass="9930" checksum="9CB818BE93E2CFB3" modified="2016-06-08" version="1">MNVRNNSTGIGGPLAVVGAAVAMIVCCAGPALIAAGALTALGGALRSWGPIVAAAVMVLAAVGYTARRRKPPQRGTVRGLLGTRRSHQPNASTDRSSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBB5</accession>
    <name>A0A132PBB5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34770</name>
        <name evidence="2" type="ORF">AWC31_10915</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859466.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10915"/>
    <dbReference type="EnsemblBacteria" id="KWX19623">
        <property type="protein sequence ID" value="KWX19623"/>
        <property type="gene ID" value="AFM11_34770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08989">
        <property type="protein sequence ID" value="ORX08989"/>
        <property type="gene ID" value="AWC31_10915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5303"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX08989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="254" mass="27064" checksum="2947BA449EE922EF" modified="2016-06-08" version="1">MTLEIHDANRVRTLTLNRPEALNAFNEALYDELTNALRAAADDPEVAVVLLTGAGRAFSAGNDLVEMQTRITNPDFTPGEHGFYGMIETLTAFDKPLICAVNGVGVGIGTTILGFADLAFMSATARLKCPFTSLGVAPEAASSYLMPRLLGRQNAAWLLMSSEWVSAAEAREMGLVWKVCEPDDLLTEARRHAEILATKPISSLQAVKQTMVAPLRDAIVAATEREKALFVELVGAAANADALAAFADRKGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBC0</accession>
    <name>A0A132PBC0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859732.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19547">
        <property type="protein sequence ID" value="KWX19547"/>
        <property type="gene ID" value="AFM11_35240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5779"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="95" mass="9948" checksum="F81C864B7D7E9A12" modified="2016-06-08" version="1">METLGTVQDDVSAVRDFASHVRALCAQLTANPFNTPAAEKLLDLLLEDAPTVDLAFERVLRSVIHGPASTGAPILDMLGSPRCTPHAELVVGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBK5</accession>
    <name>A0A132PBK5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859126.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19698">
        <property type="protein sequence ID" value="KWX19698"/>
        <property type="gene ID" value="AFM11_34190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5176"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="495" mass="53823" checksum="9BD7F9BC31137715" modified="2016-06-08" version="1">MATNADVVQAPWAIAGNLDAQVHETHTGVVILLGDKAYKAKKPVATDFLDFTAPTQREEACRREVALNSRLAPDSYLGVAHLVGPGCGEPEPLVVMRRYPEAIRLSTMVVKGQPVEDRLETIAETLADFHRVAERSQTIDQHGTAEAVAARWNDNLVELERYPYITSESVAEIRRLAEKYIAGRAALFAARIAGRRVVDGHADLLSDDIFCPPNGLAILDCLEFDDSLRYVDAIDDAAFLTMDFEFLGRADLGALFLDRYKAHARDDAPESLTDFYIAYRAVVRAKVDCVRAEQGCVEAADSARRHADIALTHLRAGTVQLIIVGGGPGTGKTTVSNALAQQVRAEVISTDDVRRQLQQAHIIEGQAGVLDSGLYTPEKVAAVYDEVLRRAREKLIHGVSVILDGTWRDPHQRQRARRLAAGTATPIVEFTCAVPLERASARIQSRSSTTSDATPEIAAALAEPDGHLPGGHTIDTSRPLSDSVAEAQRICCLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCB1</accession>
    <name>A0A132PCB1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamyl-tRNA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858257.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32080"/>
    <dbReference type="EnsemblBacteria" id="KWX19975">
        <property type="protein sequence ID" value="KWX19975"/>
        <property type="gene ID" value="AFM11_32705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4869"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="471" mass="50290" checksum="6CA3F989F186087F" modified="2016-06-08" version="1">MTETPADALYYREICELVDLLDRGEVTARQLTQSTLDRIAEVDQRLGAYAFVAPDEAMAKAAESDERRAAGAARGPLDGIPLAIKDIYDKQGWRTEAGMAVRSGQVASSTATVVERLDQAGAVIVGKVHTTEGVYTEHTPPFRAPLNPWDPNRWVGVSSSGSGVAPVAGLCYGALGSDTGGSIRMPSASNGATGLKPTWGRVSRAGVVELAATLDHVGPICRSARDAGLILGAIAGADPRDPTASLRPVPEFSTTTTASLSGVRIGIDPGWSYRDVSIDVEKAHQEAEQVLRDLGAELTPVTLPDPTEAITDWFGVCAVQTARAHRGLYPERKDSYGPALSELIDRGIAMSGIEYDELLQRRLIFKGQMEAALSSVDTVLIPAMSFIAPPVEKMIRMDEETTAGVHRFTVPFTLSQLPTITFPGGFTTTEAGHPFPVGLQMVGSAFDERRLVDVVGAFQAATPWNKQHPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCM3</accession>
    <name>A0A132PCM3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_34395</name>
        <name evidence="6" type="ORF">AWC31_11275</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000036">
        <property type="protein sequence ID" value="ORX08708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859234.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11275"/>
    <dbReference type="EnsemblBacteria" id="KWX19732">
        <property type="protein sequence ID" value="KWX19732"/>
        <property type="gene ID" value="AFM11_34395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08708">
        <property type="protein sequence ID" value="ORX08708"/>
        <property type="gene ID" value="AWC31_11275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5223"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX08708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="246" mass="26876" checksum="E318397BFDA0BFA1" modified="2016-06-08" version="1">MADEGVRLQKVLSQAGIASRRVAERMITDGRVEVDGRVVTELGTRVDPAVAEIRVDGSRIVLDDTLVYLAINKPRGMHSTMSDDRGRPCVGDLVEHRVRGNKKLFHVGRLDADTEGLLLLTNDGELAHRLMHPSYEVPKTYVATVIGTVPRGLGKKLRAGVELDDGPAHVDDFAVVDTVPGKTLVKVTLHEGRNRIVRRLLAAVDYPVQELVRTDIGTVSLGDQRPGSIRALSRKEIGELYQAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCU8</accession>
    <name>A0A132PCU8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20149">
        <property type="protein sequence ID" value="KWX20149"/>
        <property type="gene ID" value="AFM11_31905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4707"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="355" mass="39055" checksum="C5B998466E2A5A94" modified="2016-06-08" version="1">MVVTSCGGSENGNSGADNGPGSAAATLDKFNAMTGKERTDALVAEAQKEGTVVFYTASSGMDPIVEAFEKKYDIPVEMYSGQSDTVLQRILQEYGAGFYGADVMDDSESFSISEQGMTYEYVNPELTDKIPGYDQASNVAATRLSVYTQGWNTNLVNEDELPDTLDGFTDPKWKGKLSLDPRDWIWYTGVMDYYTTQKGWSEEQVDDMIRTLASYSTLNAGHTVQAQLLLAGEYPVSLSVYTQSIDRLLEKDPKAPVAWRKKDGSFIEPLIFQAQGATILKNAPHPAAAMLFVDFLLTEGQQMLASEDRTPTAIPQPGGPLEGIPQEKLTSVDFKKFTTERDEWTKRFDALLGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD71</accession>
    <name>A0A132PD71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_31640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857616.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26255"/>
    <dbReference type="EnsemblBacteria" id="KWX20285">
        <property type="protein sequence ID" value="KWX20285"/>
        <property type="gene ID" value="AFM11_31640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4232"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="4">
        <location>
            <begin position="279"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="406" mass="42696" checksum="6E4C5B27D60B01EC" modified="2016-06-08" version="1">MTTRDAVICEPVRTPIGRYGGMFQSLTAVELGVTALKGLLARTGVAPEQVQDVILGHCYPNSEAPAIGRVVALDAGLSVTVPGMQVDRRCGSGLQAVIQACLQVRSGDNDLVVAGGAESMSNVAFYSTDMRWGAARTGVQIHDGLARGRTTAGGQFYPVPGGMLETAENLRREYGITRTEQDELAVRSHQRAVAAQAEGVLAEEIIPVTVRTRKGEETVNTDEHPRADTTVEALAKLKPVLLKQDPESTVTAGNSSGQNDAASMCIVTTPDKAAELGLRPLVRLVSWGSAGVAPNVMGIGPVPATEVVLAKAGLQLSDIDLIELNEAFAAQALAVMKEWKFGAADHERTNVRGSGISLGHPVGATGGRMLATLARELHRREARYGLETMCIGGGQGLAAIFERVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD97</accession>
    <name>A0A132PD97_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_32180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857932.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31670"/>
    <dbReference type="EnsemblBacteria" id="KWX20197">
        <property type="protein sequence ID" value="KWX20197"/>
        <property type="gene ID" value="AFM11_32180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4763"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="299" mass="31954" checksum="CEB582FC42B4515A" modified="2016-06-08" version="1">MTVIDALSGPSTSRQATDELPVGAKRRHGGTLGLLLPAVVLVLGVFVVPLGIMLWRALSEPELGLGNFAWYLTDPVQRDVLARTFTTGLIVTIVCLVIGYPYAYAMVAFGPKVRALLTMLVLVPFWTSLMVRTFSWVILLADNGPVHSVLTAIGLGDVHLIRTNLGVVIGMSQILLPFMVLPLYAVMAGIDRRLVLASSSLGARPIVSFLRVWVPLTLPGVGAGCLMVFISSLGFYVTPALLGSPDNALISQQIYAQVSSLLQWGKGGAMGVVLLVLTFLVLAVLALALRRANRQGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDB8</accession>
    <name>A0A132PDB8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bile-acid 7-alpha dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857111.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26455"/>
    <dbReference type="EnsemblBacteria" id="KWX20333">
        <property type="protein sequence ID" value="KWX20333"/>
        <property type="gene ID" value="AFM11_30735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4049"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="144" mass="16095" checksum="2A61E46D4D642841" modified="2016-06-08" version="1">MPDDIEAIKKLKARYCRFLDTKDIDAWRALFAEDVVVTLDMAVSTGGADPQTAPPLNGFDEFFPVVWGGVEHAATVHHCHTPEIDLTSETTATGIWAMEDMLFFADGSELHGAGHYHETYEKRDGTWQITSLHLTRTLLKFKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDR6</accession>
    <name>A0A132PDR6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanylyl cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20478">
        <property type="protein sequence ID" value="KWX20478"/>
        <property type="gene ID" value="AFM11_30360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3970"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="227" mass="23794" checksum="5DFA6C3D1FFD6374" modified="2016-06-08" version="1">MMLPHRETDFDTVEVTVSFVDLAGYSVLTEICGDHEAARLAARLADLAHAALQPGVQLVKTIGDAVMLAADTPTQMVATLVGLAERVAGEDGFLAIRAGVHHGPAISRGGDFFGHAVNIAARITALAGAGHAVLTDAIVEAATAHGLPTTPMGAPALRNITTPIPLHTVALAAARYPRDPVCGMRIDPATAPAHRHHEGRDWWFCSADCAHRYTTAPSCYTSLGQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDU4</accession>
    <name>A0A132PDU4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20464">
        <property type="protein sequence ID" value="KWX20464"/>
        <property type="gene ID" value="AFM11_30270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3951"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="109"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="243" mass="25331" checksum="7B09F3A988ACC81F" modified="2016-06-08" version="1">MQAAWRLAKLVEQERVDQLLLVQDVAEKAGVSRAMVSRLINHAEIPGRRAKRDAIAAALGWQPGTFDAVLAGAQVTVSPDGADGEQAQPAEIGLIADVDRAAATRLAERIDDARNAIGLSKLDLSRLAGVSRPVVSRLINHAEVPANRKVRDALGAALGWEPGSCDAVLAGGEPALRPAARASLLLAERLREIAAEADAAAADSDQQAQRWREIGESARAAAELALRGGGGIPVCASTQLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDY4</accession>
    <name>A0A132PDY4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_30640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00630"/>
    <dbReference type="EnsemblBacteria" id="KWX20541">
        <property type="protein sequence ID" value="KWX20541"/>
        <property type="gene ID" value="AFM11_30640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4029"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453225" evidence="5">
        <location>
            <begin position="20"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="84"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="172"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="32924" checksum="8400A03A50989827" modified="2016-06-08" version="1">MLTTLTLASSLGSGPPALAEPEGPLPPAPVEPIQLPPSDPLALPPAGDPLPAPAAPLGQPAGTGTPAGQNPLPFTGQPPFLPPSFNPVDGSLVGVAKPIYINFQRPIADRQMAENAIHISSSPPVPGKFYWMSDTQVRWRPIDFWPAGTVVNIDAAGTKSGFRVGDALVATIDDKTHQMEVVRNGKLEKTFPISLGKPGYETPNGTYYVLEKFADIVMDSSTYGVPVNSPEGYKLKVQNAVRIDNSGIFVHSAPWSVADQGKRNVSHGCPNLSPANAQWFFDNFGSGDPVVVKNSVGLYDQPDGAQDWQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE08</accession>
    <name>A0A132PE08_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856464.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20561">
        <property type="protein sequence ID" value="KWX20561"/>
        <property type="gene ID" value="AFM11_29610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3813"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="248" mass="26202" checksum="1D83BAEA936DC20C" modified="2016-06-08" version="1">MDHVRKVVVITGAGSGIGRATARVLLDAGHDVVLAGRRADRLSETAQNRPDARIVPTDVTDVGSVKALFADAVATFGRVDVLFNNAGVFGPSASVADIDDEHWHATWRTNVDGAVFCAREAARVMAGQLPRGGRIINNGSLSAHRPRPNSLAYTVTKHAISGLTASMLLDLRDIDICVTQIDIGNAATDMTAGFGNQTRQADGSLAAEPTFDVEHVARAVAHLVDLPLEVSVPSLTVMARAMPYFGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE16</accession>
    <name>A0A132PE16_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856844.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20467">
        <property type="protein sequence ID" value="KWX20467"/>
        <property type="gene ID" value="AFM11_30290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3955"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="98" mass="10683" checksum="73EFFD91AEC0AA56" modified="2016-06-08" version="1">MTGMQRYDHARMIEHATSQASLVTRMTELKQGADNAIHSIAEIWQQHGSNAAQECHAQIALAFQQVFDTINRHGSAIQGASQNAETTDFGAAAGFRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE41</accession>
    <name>A0A132PE41_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856561.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25145"/>
    <dbReference type="EnsemblBacteria" id="KWX20595">
        <property type="protein sequence ID" value="KWX20595"/>
        <property type="gene ID" value="AFM11_29805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3853"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="31119" checksum="EABFEBA872A9AF83" modified="2016-06-08" version="1">MSTNEIHGILAYPVTPFTADNDVDTGKLAALVERLVADGAHGIVPLGSTGESAYLTEAEFDAVVDTTIGVVGRRVPVIIGASDLTTANTIRRAQYAERAGADAVMVVPISYWKLSERELRQHYAAIGAAIGIPIMVYNNPATSGIDMSPELLVSMFEDIDNVTMVKESTGDLSRMQRIAELSDGQLPFYNGNNPLALKAFNAGAKGWCTAAPNLRPQPCLDLYEAVRAGDGSRAEALYEGLRPLLEFIVAGGLPTTVKAGLELLGQGVGDPRPPLLPLDDDGRTQLSRLLTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PED3</accession>
    <name>A0A132PED3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20685">
        <property type="protein sequence ID" value="KWX20685"/>
        <property type="gene ID" value="AFM11_29100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3702"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="110" mass="12083" checksum="924712CE0EDA27EA" modified="2016-06-08" version="1">MARKNYPDEFKRDAVALYRDTEGATITQIADELGISGVTLSAWCKSAGVPIRHRNPSSAGEPAPGAETPDQELARLRVEVGHLRADKTRLATERDILRSAAKYFAGETNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEH3</accession>
    <name>A0A132PEH3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2,3-dehydroadipyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_29385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011331215.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20723">
        <property type="protein sequence ID" value="KWX20723"/>
        <property type="gene ID" value="AFM11_29385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3768"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="262" mass="26996" checksum="B4DCD20AC50D3000" modified="2016-06-08" version="1">MNPDNAPLRTARDSHLLILEINRPKARNSLNEAVLTALNTELVAARHDDEIRAIVLTGAGGIFCAGADITNFDAIRDQSLLGDRAALGGTIWADLGRFPKPVLAAVEGLALGGGCELALACDIVIAGESAKFGVPEVKLGVIPGGGGTQRLIQAVGKSKAMALLLTGDFLSAQRACAAGIVAETVPDGTALEAAVAMAQRIAANSPLAVALAKDAALQALETSLAQGLEHEKRNFHVAIHSADSREGQAAFLAKRAPEFTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEQ9</accession>
    <name>A0A132PEQ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase SNF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856080.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32645"/>
    <dbReference type="EnsemblBacteria" id="KWX20764">
        <property type="protein sequence ID" value="KWX20764"/>
        <property type="gene ID" value="AFM11_28365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3547"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="256"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="654" mass="72152" checksum="F993693C23C088C6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF55</accession>
    <name>A0A132PF55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855728.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20904">
        <property type="protein sequence ID" value="KWX20904"/>
        <property type="gene ID" value="AFM11_27845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3443"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="134" mass="14936" checksum="91793BEA1EC1DEE8" modified="2016-06-08" version="1">MTTGDPKEERLQIGEVAARTELSIKTIRHYDEVGLVTPSARSAGGFRLYTAADVDRLLAIRRMKPLGFTLDEMRELLAALETVHAPAASKSERAQALTYLGECHARAREACDKLSRQLSYARELTAQLADYRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF70</accession>
    <name>A0A132PF70_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856705.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25080"/>
    <dbReference type="EnsemblBacteria" id="KWX20642">
        <property type="protein sequence ID" value="KWX20642"/>
        <property type="gene ID" value="AFM11_29740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3840"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="2">
        <location>
            <begin position="444"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="674" mass="72679" checksum="824DE9AE4B63AC77" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFJ8</accession>
    <name>A0A132PFJ8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_27410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855454.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07345"/>
    <dbReference type="EnsemblBacteria" id="KWX21101">
        <property type="protein sequence ID" value="KWX21101"/>
        <property type="gene ID" value="AFM11_27410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3356"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="406" mass="43802" checksum="4F77A562C8B84587" modified="2016-06-08" version="1">MCSVEQQSDPLVGTVLDGRYRVDTPIATGGMSTVYRGLDTRLDRPVALKVMDSRYSGDEHFLTRFQREARAVARLKAPGLVSVYDQGIDRQHPFLVMELIEGGTLRELLTERGPMPPHAVAAVLEPVLGGLAVAHRAGLVHRDIKPENVLISDDGDVKIADFGLVRAVAEAKITSTSVILGTAAYLSPEQVATGDADPRSDVYAVGILTYELLTGTTPFTGDSALAVAYQRMDHDVPAPSTVIAGVPRQFDDLVRRATNRDPAGRHADADAMSAELDTIVADLGLPAFRVPAPRNSAQHLAATRFHSRQDATTDVTAPPRPAPPRQATREITRDQHDWAPIPAEPDDTDEYSGVASQFAGIEMSEFYWAQQRAKRALLFWVVAVLTLTGLAAAAAWTLGSNIGTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG07</accession>
    <name>A0A132PG07_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Decaprenylphosphoryl-beta-D-ribose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855112.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22515"/>
    <dbReference type="EnsemblBacteria" id="KWX21260">
        <property type="protein sequence ID" value="KWX21260"/>
        <property type="gene ID" value="AFM11_26820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3235"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="460" mass="50412" checksum="8C0AC3B498DA0454" modified="2016-06-08" version="1">MATTEFPTTTKRLMGWGRTAPTYAHVLSTSDPEVIIKAVVATAEEGGRGVIARGLGRSYGDNAQNGGGLVIDMAALNRIHSIDSGTRLVDVDGGVNLDQLMKAALPHGLWVPVLPGTRQVTIGGAIGCDIHGKNHHSAGSFGNHVRSMELLTANGEVLHLTPDGDNADIFWATVGGNGLTGIILRATIEMTPTETAYFIADGDVTKTLDETIAFHSDGSEANYTYSSAWFDAISKPPKLGRAAISRGSLAKLDQLPPKLQKNPLKFDAPQLLTLPDIFPNGLANKFTFMPIGELWYRKSGTYRNKVQNLTQFYHPLDMFGEWNRAYGSAGFGQYQFVVPTEAVEEFKGIIYDIQRSGHYSFLNVFKLFGPGNQAPLSFPIPGWNVCVDFPIKAGLNEFLNDLDKRVLEFGGRLYTAKDSRTTAETFHAMYPRIDEWIAVRRKVDPDGVFVSDMARRLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG28</accession>
    <name>A0A132PG28_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Arabinosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFM11_26785</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the emb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855174.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22550"/>
    <dbReference type="EnsemblBacteria" id="KWX21281">
        <property type="protein sequence ID" value="KWX21281"/>
        <property type="gene ID" value="AFM11_26785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3228"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052636">
        <property type="term" value="F:arabinosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071766">
        <property type="term" value="P:Actinobacterium-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032731">
        <property type="entry name" value="Arabino_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042486">
        <property type="entry name" value="Arabino_trans_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007680">
        <property type="entry name" value="Arabino_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040920">
        <property type="entry name" value="Arabino_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027451">
        <property type="entry name" value="EmbABC_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14896">
        <property type="entry name" value="Arabino_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17689">
        <property type="entry name" value="Arabino_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04602">
        <property type="entry name" value="Arabinose_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Arabino_trans_N" evidence="15">
        <location>
            <begin position="31"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Arabinose_trans" evidence="13">
        <location>
            <begin position="195"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Arabino_trans_C" evidence="14">
        <location>
            <begin position="680"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KWX21281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1055" mass="113535" checksum="355EF6EDE2CC0D98" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG31</accession>
    <name>A0A132PG31_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854475.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36210"/>
    <dbReference type="EnsemblBacteria" id="KWX21319">
        <property type="protein sequence ID" value="KWX21319"/>
        <property type="gene ID" value="AFM11_25685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3001"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="283" mass="31645" checksum="9BDD93F8F77ABD51" modified="2016-06-08" version="1">MPNEAARRELGGFLRIRRESVDRAQHGLPPIRGRQTGLRREEVAYLSSISVTWYTWLEQGRDINPSRQVLEAIGGALALSPTDQAYLLSLAGFSSGGTHQNLPAPGEPPEHIQRLLNAFGSSPAFAIDPDWGIVAWNPAYAALYPRVQSVPADERNLLWLVFTDPSIKELMPDWGVESRRFVSEYRMQNGARLHEGPVTRLLDRLRAASPEFEGTWDDHTIEGFQTRVRRFRHAVTGEMDLEYHRLSPADLPDLNIVVYTPATARAAEQLGRLADGRAVSRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGG4</accession>
    <name>A0A132PGG4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854727.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36095"/>
    <dbReference type="EnsemblBacteria" id="KWX21403">
        <property type="protein sequence ID" value="KWX21403"/>
        <property type="gene ID" value="AFM11_25800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3024"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="32306" checksum="58AE0CBE0FD1B296" modified="2016-06-08" version="1">MELRHLRYFAAVADTCHFGQAAEQLHVAQPALSYAIRQLEAELDVTLFNRTTRQVSLTAAGEFLRGEAIRILAGVDDAERGVRRIARGRGGLLRLGLTGTAAFSHLPRIARMVKRELPAVALEIQADMLTPEQCDGLRTGALDLGVLRPPAVGEGIEMATIDVESLVLAVSVDHRLAVEPVVSLTDLRTEPFIAYASRDSAVNDAVLRSCRSAGFVPHREHAAPGTAVLLALVAADLGVAVVPESVRALPLDGVVFRDLVDGGTIELALAWRRDTDNPVVDTVVEILASALRREPLEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGI4</accession>
    <name>A0A132PGI4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lycopene cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_24885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854055.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27140"/>
    <dbReference type="EnsemblBacteria" id="KWX21455">
        <property type="protein sequence ID" value="KWX21455"/>
        <property type="gene ID" value="AFM11_24885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2338"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016120">
        <property type="term" value="P:carotene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18916">
        <property type="entry name" value="Lycopene_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Lycopene_cyc" evidence="9">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="115" mass="13164" checksum="38412914C7FC798F" modified="2016-06-08" version="1">MDRWHYLLVLAACLLITLPLEFLGTGVYRRPVRTARAVLPVAAVFVVWDALAIGADVWTYNPRYISGIHLFGVMPLEELLFFIVIPLCGLLTFTAVDNLLHKGRRLWSQRREVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGL6</accession>
    <name>A0A132PGL6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate carboxylase</fullName>
            <ecNumber evidence="5">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_25090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854148.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27410"/>
    <dbReference type="EnsemblBacteria" id="KWX21489">
        <property type="protein sequence ID" value="KWX21489"/>
        <property type="gene ID" value="AFM11_25090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2379"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2 5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="121"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="12">
        <location>
            <begin position="524"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="8">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="732"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="734"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="867"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX21489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1127" mass="120606" checksum="ADAB1FAEAA61E520" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH17</accession>
    <name>A0A132PH17_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853629.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23925"/>
    <dbReference type="EnsemblBacteria" id="KWX21630">
        <property type="protein sequence ID" value="KWX21630"/>
        <property type="gene ID" value="AFM11_24190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2197"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="100"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="264" mass="29180" checksum="5E58F6E0D223F359" modified="2016-06-08" version="1">MVVLFFAAFVTFLVLFIVSRRQLTNARREIERMQLENDDRRRRKRRGVAPLAIKTVFQTADMLINKGLGATVRNSIEDLAGWAQVERPDLARLTADGRVVIVFSDIEGSTESNAAMGDRAWVKLLDRHNRLVENCVGQHGGHVVKTQGDGFMIAFADPENAVRFATAVQHALAEKPERWQGIRVRMGIHMGTSVRRGDDLFGLDVAMAARVADQADGGEILVSEPVADTVADLDDVMLGAPREAELKGLPGTHRLFPVMIEQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH58</accession>
    <name>A0A132PH58_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853755.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21670">
        <property type="protein sequence ID" value="KWX21670"/>
        <property type="gene ID" value="AFM11_24460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2253"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08417">
        <property type="entry name" value="PBP2_Nitroaromatics_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037402">
        <property type="entry name" value="YidZ_PBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="305" mass="33703" checksum="7A28964411CF9F3F" modified="2016-06-08" version="1">MHMAHIDRIDLNLIPPLVALIEERQVSRAAERVGLSQPAMSRALQRLRRLLDDPLLIRDSTGYRLSARAESIQAQLNIVLPQLETIFAPADFDPRASTRPVQLAATDYGVQTFGPAICGELLRQSPHTPVRFHSWTPDGVADQIRNSAIDLGLYGGFATADLHSEELLVERFVCVVAADHPLADAGSIALPEYCRARHVIVDVHDGLQPDIDLPLAELGMPRRPAVTVAYHAVATQLLPGTDLIATLPSQAVATSMPADQLRVLRAPDEIATLPYRMVWHPALDNDRRHQWIRDVVRSAVRQRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH63</accession>
    <name>A0A132PH63_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853838.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23485"/>
    <dbReference type="EnsemblBacteria" id="KWX21698">
        <property type="protein sequence ID" value="KWX21698"/>
        <property type="gene ID" value="AFM11_24635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2288"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045382">
        <property type="entry name" value="DUF6529"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20139">
        <property type="entry name" value="DUF6529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="200" mass="21668" checksum="4312318C469CE4C8" modified="2016-06-08" version="1">MFSEPPPESDFHAAPTRPAPVIAPRGTALVLVPVLVGAAVAVALGVFGRVHEPQFFSVSVAGFSSGTAVKSWLATVAVTLAVFQLVSAFVMYRLTPSGRAPSWIAPAHVWSGRLAVLASVPVAVHCLYALGFQSGDSRVFFHSLFGCFFYGVFVTKMMLLTRKNLRPWVIPIIGGLLFFVLVYVWLTSALWFFETTGLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHC1</accession>
    <name>A0A132PHC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853737.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23715"/>
    <dbReference type="EnsemblBacteria" id="KWX21664">
        <property type="protein sequence ID" value="KWX21664"/>
        <property type="gene ID" value="AFM11_24410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2242"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="296" mass="32251" checksum="E594390D8C50A530" modified="2016-06-08" version="1">MELRQIEHFIAVAGEMSFTRAAHRAHVVQSALSTSIAKLERELGVELFDRSRQQIKLTAAGERFLTHSYDVMRAARAATESIGEYRGALSGTVEFGSLISFGPISVARALGDFHRAHPFVRIRLHLSQSGASAYLTALIEGSLDLALVSVPNRFPPQLDMRLLFEEPMVFVCRDDHAYARKKRVGFGELAAEDLVGLPSEFGLRRLMDDAFRAAGAEAHTQYEVPAGFAAIADLVGNGLGTSFMPVSEARRFPELKSIDLADPVIWQVYLASPPAEQLTPATARLADTLLTAAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHL7</accession>
    <name>A0A132PHL7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27890"/>
    <dbReference type="EnsemblBacteria" id="KWX21754">
        <property type="protein sequence ID" value="KWX21754"/>
        <property type="gene ID" value="AFM11_23125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1977"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="89"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="223" mass="23937" checksum="15D09509FDF39278" modified="2016-06-08" version="1">MGTRTGLLITTAVAAAAVYALMWVGYGASWGWVVRLDDAGLDWPFRYGSTHPGWVMAWDVFCTVFGPMAFRLVGAVIIVVALVRRHFRLALFLLLTVELNGIVIQLAKIIADRPRPSSALVYASWSSFPSGHALGVLVSVLGLLVVAWPALRPALRRWLPIAGAVLVIAIGVGRVVLNVHHPSDVLAGWALGYAYFVVCLVLAPPYPAVSATDETPVALGSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHT2</accession>
    <name>A0A132PHT2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_23765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853360.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29880"/>
    <dbReference type="EnsemblBacteria" id="KWX21863">
        <property type="protein sequence ID" value="KWX21863"/>
        <property type="gene ID" value="AFM11_23765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2110"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453094" evidence="7">
        <location>
            <begin position="29"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="630"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="201"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="518"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="668" mass="68474" checksum="7C91764DF488412B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ32</accession>
    <name>A0A132PJ32_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_22155</name>
        <name evidence="6" type="ORF">AWC31_04915</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852562.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04915"/>
    <dbReference type="EnsemblBacteria" id="KWX22197">
        <property type="protein sequence ID" value="KWX22197"/>
        <property type="gene ID" value="AFM11_22155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10629">
        <property type="protein sequence ID" value="ORX10629"/>
        <property type="gene ID" value="AWC31_04915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1780"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="26"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="180"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX10629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="439" mass="47956" checksum="2B2A6CE14B205972" modified="2016-06-08" version="1">MLRPPKPDTPLETSHVRRTTLPGGLRVVTEYIPSVHSASVGVWVGVGSRDEGRSVAGAAHFLEHLLFKATPTRTAVEIAQAVDAVGGELNAFTAREHTCYYAHVLDTDLELAVDLVADVVLRGRCAADDVEVERDVVLEEIAMRDDDPEDTLGDVFLSAMFGDHPVGRPVIGSVESISAMTRAQLHSFHMRRYTPDRMVLAVAGNIDHDEVVALAHEHFGKRLVSGRNAIAPRKGSGRLSGRPTLEVMDRDGEQMHVSLGVRTPGRHWKHRWALSVLNTALGGGLSSRLFQQIRESRGLAYSVYSTVDTFSDSGALSVYAGCQPERFDEVVRLTTDVLESVARDGITENECRIAKGSLRGGLVLGLEDSASRMHRIGRSELNYGEHRSIERTLTQIESVTLDEVNAVARQLLTRDYGAAVLGPQKSKHSLPQRLRAIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ62</accession>
    <name>A0A132PJ62_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diaminobutyrate--2-oxoglutarate transaminase</fullName>
            <ecNumber evidence="5">2.6.1.76</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DABA aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_22960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11160"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.6.1.76"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.76" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08245"/>
    <dbReference type="EnsemblBacteria" id="KWX22052">
        <property type="protein sequence ID" value="KWX22052"/>
        <property type="gene ID" value="AFM11_22960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1945"/>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045303">
        <property type="term" value="F:diaminobutyrate-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047307">
        <property type="term" value="F:diaminobutyrate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012773">
        <property type="entry name" value="Ectoine_EctB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552:SF2">
        <property type="entry name" value="PTHR43552:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02407">
        <property type="entry name" value="ectoine_ectB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="429" mass="46217" checksum="367344F978BCBAD7" modified="2016-06-08" version="1">MLTLATTAPMTESDLPEVFSSVESEVRSYCRGWPTVIQSATDSWVTDTDGRRYIDFFAGAGALNYGHNNPALKAPLMQYLASDGIVHSLDMATEAKQRFLEAFQRVILKPRGLDYKVQFPGPTGANSVESALKLARKVTGRESVISFTNAFHGMTLGALSVTGNSMKRAGAGIPLVHATPMPYDNYFGGVTEDFQWFERVLDDSGSGLNRPAAVIVETVQGEGGLNVARIEWLQALADLCRTRDILLIVDDVQMGCGRTGPFFSFEAAGIVPDIVTLSKSVSGYGLPMALTLFRRDLDVWAPGEHNGTFRGHNPAFVTATAALENYWATSQFSSDVTLKGNLIRARLEEIAARYDGVSARGRGMAQGLKFEDDVRAGEVCRAAFDRGALMETSGPSDEVVKLLPPLTTSAGDLEAGLDILAESIAVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK02</accession>
    <name>A0A132PK02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_20445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851961.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22517">
        <property type="protein sequence ID" value="KWX22517"/>
        <property type="gene ID" value="AFM11_20445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1423"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Hemerythrin" evidence="8">
        <location>
            <begin position="632"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="774" mass="81260" checksum="3269EC56E6F1E88E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKB8</accession>
    <name>A0A132PKB8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_17645</name>
        <name evidence="9" type="ORF">AWC31_05165</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851109.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05165"/>
    <dbReference type="EnsemblBacteria" id="KWX22775">
        <property type="protein sequence ID" value="KWX22775"/>
        <property type="gene ID" value="AFM11_17645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10672">
        <property type="protein sequence ID" value="ORX10672"/>
        <property type="gene ID" value="AWC31_05165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.884"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="15"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX10672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="226" mass="24224" checksum="3A3EEA2EF800A89D" modified="2016-06-08" version="1">MEIFTEYRDEIFAAFWTTIQLTVYSAVGALILGTVLAAMRLAPTPVMNWIGTTYVNIVRNTPLTLIILFCSFGVGQTLRITLVDPNSPTSITDSNFRLAVLGLTVYTASFVCETVRSGVNTVPLGQAEAARSLGLTFGQNLRLILLPQAFRAVIIPLGSVLIALTKNTTIASAIGVAEAALLMKEMIENTAALIAVGTIFAVGFILLTLPLGLFFGWLGKRLAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKJ8</accession>
    <name>A0A132PKJ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12335"/>
    <dbReference type="EnsemblBacteria" id="KWX22870">
        <property type="protein sequence ID" value="KWX22870"/>
        <property type="gene ID" value="AFM11_18265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1010"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="80"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="456" mass="51006" checksum="D2D7AA072B3CDC09" modified="2016-06-08" version="1">MPLAGFTARAAGGRVVAALRKQAGDAGAVDRFHERTAERYAELLGHSKGVLMKAGQMVSMVDATAVGFGELSPYQRALTRLQGDAPPMDPRLAREVVEADLGRAVADVFADFSDEPMAAASIGQVHRATMRDGREVAVKVQYPGVAEAIRDDLANAELLTTFVRFMNSTVPGSMPDLRRASQELTERISEELDYRHEAANITAFSELYRDHPYIRIPEVVPEASGDRVLTMTYLDGMDWAEALTADQDLKNCWAEVISRMLTGSYRHSNLFHADPHPGNYRFRTDGTVGFVDFGCVKVLPWQRRWQMLRMARAVVEGRKEDLRDVMAESGFLAEDSTLTADEAYQWWSTLMHELLIPQPVTYTREASERSVRSLLDVRATDHPVRRMSVPADFVFFSRLNLSMNSIFTALGATFYARASLDDMDGVIEPVSDLGKQHIAWVRQRGLPFGMDHRDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKQ8</accession>
    <name>A0A132PKQ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851453.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22935">
        <property type="protein sequence ID" value="KWX22935"/>
        <property type="gene ID" value="AFM11_18240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1005"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="28581" checksum="247924E5AC0A63EE" modified="2016-06-08" version="1">MVRKRRKREWPGRPRDVWAEASRRHGVPSLPRPEVPNWRDIEVFGSRVLLHPATPSPPATVGFGAFTAMLALLAWWKDHPTLLVGALGVAAAILVSVGCFWMWWVPARRERRLSRTHARALDYGVGAHAYRTRFTRPEESSQPRTTSLLIDERLPTFAASRLQHAVRDWLARVTADAAMNAEAVHLLGRRWVVPITEIFGPDAHGGWLVIDQGEDDTPWRLLIDRPDGPEEYFYDEVMAIDGPPGRLYLDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL26</accession>
    <name>A0A132PL26_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain-acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_16920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850805.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01490"/>
    <dbReference type="EnsemblBacteria" id="KWX23050">
        <property type="protein sequence ID" value="KWX23050"/>
        <property type="gene ID" value="AFM11_16920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.737"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030310">
        <property type="entry name" value="FadD17/FadD6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="PTHR43107:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="53"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="469"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="593" mass="63795" checksum="E598CB73BA9C00D0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL41</accession>
    <name>A0A132PL41_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Propanediol dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851803.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15050"/>
    <dbReference type="EnsemblBacteria" id="KWX22722">
        <property type="protein sequence ID" value="KWX22722"/>
        <property type="gene ID" value="AFM11_18960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1126"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010254">
        <property type="entry name" value="B12-dep_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003208">
        <property type="entry name" value="Dehydtase/Dehydtase_re"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036999">
        <property type="entry name" value="Diol/glycerol_deHase_lsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003206">
        <property type="entry name" value="Diol/glycerol_deHydtase_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02286">
        <property type="entry name" value="Dehydratase_LU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02288">
        <property type="entry name" value="Dehydratase_MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52968">
        <property type="entry name" value="SSF52968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dehydratase_LU" evidence="1">
        <location>
            <begin position="2"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="739" mass="78426" checksum="882D1AE0070976B6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL82</accession>
    <name>A0A132PL82_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_16325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850586.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19995"/>
    <dbReference type="EnsemblBacteria" id="KWX22947">
        <property type="protein sequence ID" value="KWX22947"/>
        <property type="gene ID" value="AFM11_16325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.613"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="170" mass="17702" checksum="43EFB47C38318537" modified="2016-06-08" version="1">MAADAAILILRVVLGLTMAAHGYNKFFGGGRIPGTAGWFESIGMKPGMFHARVAATTEITAGLGLALGLLTPVPAAGFVALMLVAAWTVHRANGFFIVKEGWEYNLILAVAAVAIAGTGAGRYSLDYVLFSGTGFYDYLHGWWGLAIAAVLGLAGGVGQLAIFFRPPVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLA1</accession>
    <name>A0A132PLA1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recX</name>
        <name evidence="6" type="ORF">AFM11_17625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851101.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05145"/>
    <dbReference type="EnsemblBacteria" id="KWX22772">
        <property type="protein sequence ID" value="KWX22772"/>
        <property type="gene ID" value="AFM11_17625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.880"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="186" mass="21096" checksum="4BC9B06AD2DACB7B" modified="2016-06-08" version="1">MTSYPPRLTSESPGKPEGEQAQDPRAREEQAKNVCLRLLTVRARTRSELEAQLTKRGYPDDVSARVLDRLAEVGLIDDEDFAEQWVRSRHANAGKGKRALAVELRKKGLDDEVISSALADLDPAAERQRAEQLVRDKLRRERLADDDDVKVTRRLVGMLARRGYSQSMAFDVVSVELASERERRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLE8</accession>
    <name>A0A132PLE8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_15175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850133.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15795"/>
    <dbReference type="EnsemblBacteria" id="KWX23169">
        <property type="protein sequence ID" value="KWX23169"/>
        <property type="gene ID" value="AFM11_15175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7147"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="232"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="333" mass="36713" checksum="81656BDC8BE9E655" modified="2016-06-08" version="1">MAVIRGTALTNYHQLVAELGGDSKRLLAGVHIPFGDVGRHDRFISLANGARLLEETAAELETPDFGRQLALRQGIDILGPVGLAARTAANVAEAFAIFDTFMAAYSPAISVRIAAHPDPALRRFEFEYLLDPAPPQAQAIELSLGVTLRVLHHFLGGRYRPVAVHLPHPALTVTAQYQDYFGCAPSFSEPVAGFTLRAVDLQRTLPTDRLAHQTAVDYLARTRAGRSHPTTYVVRTLIRQLLPTGATTLADIALQVGLHPKTLQRRLRAEGATFQQIADQTRRDITEKLLLDQELTLDHICRQLGYAEQSVLTRSCRRWFGTTPSGYRADVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLT0</accession>
    <name>A0A132PLT0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_16460</name>
        <name evidence="7" type="ORF">AWC31_19860</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850633.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19860"/>
    <dbReference type="EnsemblBacteria" id="KWX22972">
        <property type="protein sequence ID" value="KWX22972"/>
        <property type="gene ID" value="AFM11_16460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16319">
        <property type="protein sequence ID" value="ORX16319"/>
        <property type="gene ID" value="AWC31_19860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.641"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX16319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="233" mass="25377" checksum="F07DEAC74169DA00" modified="2016-06-08" version="1">MVSVSIPPLKPLKRRRAPRGSGELLREQILDAATELLLETGHAKAVSIRSVAQRVGVTPPSIYLHFADKDALLDAVCARYFEKLDEEMQRVAKDQPSTIDVLRAQGLAYVSFARQTPELYRLATMGEGRPGSDVDVTLNSSAFVHMRTSVETLISEGIYPPGDPTSLALELWTAAHGVAAMLIAKPYLPWGDAEEFTDRVLRAVCTGHIVSGMIGTDLSPQEAVARLKGFAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLV8</accession>
    <name>A0A132PLV8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ORF">AFM11_16025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850436.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16600"/>
    <dbReference type="EnsemblBacteria" id="KWX23316">
        <property type="protein sequence ID" value="KWX23316"/>
        <property type="gene ID" value="AFM11_16025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7330"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX23316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="158" mass="16116" checksum="8881BFB71775C039" modified="2016-06-08" version="1">MMLPRVGLGTDVHPIEAGRPCWLLCLHFDDADGCAGHSDGDVAAHALCDALLSAAGLGDLGTVFGTGRPEWHGVSGADMLRHVHGLLQSAGYRVGNAAVQVIGNRPKIGPRREEAQRVLAELVGAPVSVSATTTDGLGLTGRGEGLAAIATALVIPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMA7</accession>
    <name>A0A132PMA7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_14410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849814.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18410"/>
    <dbReference type="EnsemblBacteria" id="KWX23470">
        <property type="protein sequence ID" value="KWX23470"/>
        <property type="gene ID" value="AFM11_14410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6990"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="182" mass="19590" checksum="82E0D3C7FC404118" modified="2016-06-08" version="1">MASSRDRILDAYEDLLAVEGERFATLDAVAARAGVSKGGLLYHFPSKDRLAEALYDRLQSLAAEDVQQMRTASEGPARHYIRTSHYAGRPLDRALLAVARLQQAGDTRARAVIESVSGEWLNVLHEALGDLDVARAVKLIGDGLYYNALSTALGGHSAGTDADDGLLEVIDRIIASTNASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMH7</accession>
    <name>A0A132PMH7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3566 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_14620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849880.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18280"/>
    <dbReference type="EnsemblBacteria" id="KWX23503">
        <property type="protein sequence ID" value="KWX23503"/>
        <property type="gene ID" value="AFM11_14620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7033"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3566" evidence="3">
        <location>
            <begin position="168"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="29747" checksum="53E92863CE4AFF3D" modified="2016-06-08" version="1">MSSPSEPGYPRAGDRPGSSTNGSAPGGEVGAAGNAASRAGGHITDSGDVPPWQRGASRTAQQPPAEARGDGSRGPAGEARAQRFVSGSETETEQQPRPAPRPEPRNEPRNEPRSEPVRPEAYASELPDLSGPVPRPPQRKTGNDSARSSGTPTTRIQVANRPQQTGPVRASMQIRRVDPWTVLKVSLVLSVVLFFVWMIAVAFLYLVLGGMGVWSKLNSNVGDLLTSASGSTGGELVSSGTIFGGAALIGLVNIVVLSAMATIGAFIYNLTTDLVGGVEVTLADRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMJ0</accession>
    <name>A0A132PMJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14810</name>
        <name evidence="3" type="ORF">AWC31_18090</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849955.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18090"/>
    <dbReference type="EnsemblBacteria" id="KWX23535">
        <property type="protein sequence ID" value="KWX23535"/>
        <property type="gene ID" value="AFM11_14810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17230">
        <property type="protein sequence ID" value="ORX17230"/>
        <property type="gene ID" value="AWC31_18090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7073"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="247"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="396" mass="42717" checksum="9191BCFF4EAA655E" modified="2016-06-08" version="1">MSSLRRGDRGGAVTEIRAALAALGLIENPDADLSTGRHVALDAFDDELDQAVRAFQQHRGLLVDGIVGEATYRALREASYRLGARTLTHQFGAPMYGDDVATLQARLQDLGFYTGLVDGYFGLQTHNALSSYQREYGLYPDGICGPETLRSLYFLGSRVTGGSPHAIREEELVRSSGPRLSGKRVIIDPGRGGADHGLIMHGPEGPISEADILWDLASRLEGRMTAIGMDTFTSRPANRSPSDAERAGTANTVGADLMISLRCATQASPAANGVASFHFGNSHGSVSTIGRNLADFIQREVVARTGLRDCRTHGRTWDLLRLTRMPTVQVDIGYITNPRDRGLLVSTQTRDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVEQAGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMQ6</accession>
    <name>A0A132PMQ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848920.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02750"/>
    <dbReference type="EnsemblBacteria" id="KWX23619">
        <property type="protein sequence ID" value="KWX23619"/>
        <property type="gene ID" value="AFM11_12490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6588"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="23602" checksum="3F53B354BEC4CFE5" modified="2016-06-08" version="1">MSTAPVAIVTGGASGIGAAVVGALQRRGYRVGALDLSGQASAEHVVRVDVSDGAAVAGAVAEIRRELGPIAALVTSAGHYEMAPVSDITAQAWHRMLRVHVGGLFNTARACLPDMLERRSGAVVAVTSELAVGGGDQDAHYAAAKGAIIGLARSLAAEVAGRGVRVNAVAPGPTDTPLLAADSPWRADDYLTTLPLRRLTSPAEVARCVEYLVCDATFSVGDVVNVNSGAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMQ7</accession>
    <name>A0A132PMQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848908.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02745"/>
    <dbReference type="EnsemblBacteria" id="KWX23618">
        <property type="protein sequence ID" value="KWX23618"/>
        <property type="gene ID" value="AFM11_12485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6587"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="253" mass="26099" checksum="7540CD389DA09ACD" modified="2016-06-08" version="1">MTSLHGRVALVTGAAQGMGAAHARRLAAAGATVAVNDIRGGAELDALATEIGGLTALGDVSDPDACARIVDGVAATAGRLDILVANHAYMTMAPLLEHDERDWWRVIDTNLGGTFQLIQAVLPHMRRLGQGRIVVIASEWGVTGWPEATAYAASKAGLISLVKALGRELAPERVIVNAVAPGVTDTPQLQVDADAAGVDLATVQQQYAKSIPLGRIGSPDEIAAAVELLSDFDLEAVVGQVISCNGGSTRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMV7</accession>
    <name>A0A132PMV7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C biogenesis protein ResC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849074.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03110"/>
    <dbReference type="EnsemblBacteria" id="KWX23670">
        <property type="protein sequence ID" value="KWX23670"/>
        <property type="gene ID" value="AFM11_12790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6650"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="21"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="26272" checksum="1EC5221E4CFF9DDF" modified="2016-06-08" version="1">MTGFAEIAAAGPVLLALAVSVLAGLVSFASPCVVPLVPGYLSYLAAVVGVAEDQPGQVAVKTARLRVAGAAALFVAGFTVVFLLGAVAVLGMTTTLIANQLLLQRIGGVVTIVMGLVFVGFIPALQRQARFTPRQLSTVAGAPLLGAVFALGWTPCLGPTLTGVIAVASATDGSTVARGVALVLAYCLGLGIPFVLLALGSARAVQGLGWLRRHTRTIQIFGGVLLILVGTALVTGLWSEFVSWVRDAFVSDVRLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNE3</accession>
    <name>A0A132PNE3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Betaine-aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849415.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23784">
        <property type="protein sequence ID" value="KWX23784"/>
        <property type="gene ID" value="AFM11_13500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6795"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="36"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="496" mass="51761" checksum="AA137108F5A466EC" modified="2016-06-08" version="1">MTATNDLETLMTARAREFATASHGAFIGGSHIAPDGPAIADVDPSTGAVITQIADSGAEIVDAAVRSAAQAFEGDWGAMLPGQREAALHRLADLVEQHAAELAEYDALEGGKPVSYVEAVDLPLAVEQFRYYAGWPTKLTGSVVPVDTPDSHVYTRRTPLGVVAAVTPWNFPLCQAAIKLAPALAAGNTVVLKPSELTSLSALRLAELAMEAGLPPGTVNVVTGSGATTGDALISHPQVAKISFTGSEKVGRQLGGRAGEALKHISLELGGKNPNVVFADADIAKAAAAAATTAYFYSGQVCFSGSRLMVQRPVLDEVLDEVRRHAEALVIGPGLDRASTMGPLASSGHRDKVEGYLETVTGTGARVAFGGSRVPGTGFFLEPTAVVGPADSDPVVTDEIFGPVLVVQPFDTVDEVLPRANDTRYGLTAGVWTSDVRKAHAFSQRLQAGLVWVNTYADYNAAAAFGGFKSSGFGKDCGPEGLEKYLQTQTIWMSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNS4</accession>
    <name>A0A132PNS4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DGPF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11350</name>
        <name evidence="4" type="ORF">AWC31_30545</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848184.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30545"/>
    <dbReference type="EnsemblBacteria" id="KWX23965">
        <property type="protein sequence ID" value="KWX23965"/>
        <property type="gene ID" value="AFM11_11350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12338">
        <property type="protein sequence ID" value="ORX12338"/>
        <property type="gene ID" value="AWC31_30545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6347"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX12338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="135" mass="14784" checksum="491321C61D688424" modified="2016-06-08" version="1">MAKYLLLKHYRGAPAAVNDVPMDQWAPEEVQAHLKYMNDFAARLEASGEYVDSQALAPEGAWVRYDGEGKPPVTDGPFAETKDLIAGWMIIDVDSYERAVELAGELSAAPGAGGKPIHEWLEVRPFFHAAPTVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNT6</accession>
    <name>A0A132PNT6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_12685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849558.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02965"/>
    <dbReference type="EnsemblBacteria" id="KWX23857">
        <property type="protein sequence ID" value="KWX23857"/>
        <property type="gene ID" value="AFM11_12685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6627"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="445" mass="47172" checksum="7C38FEFCF183560A" modified="2016-06-08" version="1">MSDVAAQTVRLVDYEDAPLTRFQIRVTIAGTGGQFSDGFILGIIGIVITSATGALGLTPLWIGLLGAATLAGLFLGAVVTGPIADRLGRRHIFAWDMLVFAALSAVQFFIESPSQLLALRLLIGVVLGADYVVSKSLVTEHAPRRFRGRLMSLLAVAWAGGYVAAYLVGFLLTNIEGESWRYMLAASAVPALLILGFRLGVPESPLWLTQHGRTAEAAAVVSRHLGANVRPPAIEPNPPRRNISALFTPKYRKRTMVGALFYICQVIPFFALGTFSPQVMESLGVTSKLGAGAAYNIFLLVGAVLGLLVIDRITRRSFLIGTFFVGAGLLAALVIFSDTNSAVKVALFALFALVLAAAVNLEFVYPPELFPTDLRASGVGIAVAASRIGSAVSTFLLPIVVAQYNVNVALIGCVVVLAIGGFTCWAWAPETRDESLNEVDGNVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNV7</accession>
    <name>A0A132PNV7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-ACP reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG</name>
        <name evidence="1" type="ORF">AFM11_11610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848330.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30440"/>
    <dbReference type="EnsemblBacteria" id="KWX24005">
        <property type="protein sequence ID" value="KWX24005"/>
        <property type="gene ID" value="AFM11_11610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6399"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="450" mass="46495" checksum="7D6C4EA331F2EE02" modified="2016-06-08" version="1">MASDLFSQVLTSGPGSFLAKQLGVPQPETLRRYRPGDPPLAGSLLIGGSGRVVEPMRAALADDYDVVSNNIGGRWADSFGGVVLDATGITDAAGLKELYTFFTPLLRNLGSCARVVVVGTTPDQAASVHEQIAQRALEGFTRSLGKELRRGATAALVYLAADAKPAATGLESTLRFILSAKSAYVDGQVFRVGPEDSTPPADWDKPLAGKVAVVTGAARGIGATIAEVFARDGATVVAVDVEGASDDLHKVAHKVGGTALTLDVTADDAVDKITAHVTEHHGGKVHVLVNNAGITRDKLLANMDEGRWDAVIAVNLLAPQRLTEGLVANGTLGEGGRVIGLSSMAGIAGNRGQTNYATTKAGMIGLTEALAPVLAEKNITINAVAPGFIETKMTEAIPLATREVGRRLNSLFQGGQPVDVAETIAYFASPASNAVTGNTIRVCGQAMLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNX6</accession>
    <name>A0A132PNX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848322.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30460"/>
    <dbReference type="EnsemblBacteria" id="KWX24003">
        <property type="protein sequence ID" value="KWX24003"/>
        <property type="gene ID" value="AFM11_11590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6395"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="215" mass="23603" checksum="4047AFC2FD002F51" modified="2016-06-08" version="1">MTRLAIAEDNAILRDGLTQLLLERGHDVVAKVGTAEELRDIADTLSPEVFVIDIRMPPTYTDEGLVAAVSLRRTHPHIGVLLFSQWVETRYAAELLAGRPEGVGYLLKDRVADIGEFDNAVRRVAAGGTALDPEVVRQLMGARRGVDVLDRLTAREREVLALMAEGHSNSGLADKLSISERAVEKHVTSIFTKLDLPPSQAHHRRVLAVVTYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP65</accession>
    <name>A0A132PP65_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_12155</name>
        <name evidence="11" type="ORF">AWC31_09820</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09820"/>
    <dbReference type="EnsemblBacteria" id="KWX24105">
        <property type="protein sequence ID" value="KWX24105"/>
        <property type="gene ID" value="AFM11_12155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09231">
        <property type="protein sequence ID" value="ORX09231"/>
        <property type="gene ID" value="AWC31_09820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6510"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="228"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX09231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="446" mass="47231" checksum="3F44E286ED4CECA1" modified="2016-06-08" version="1">MRLFRFIRSASLRTRVAVASAAAAAAVVAAFTILTSLVLVNNDAAQLDRRLDSIVDASINPEHLQDPRRGVLTTGRSRSTGQVVFQRGFQLPALPPGTETVQVNGVDYRVRTIQVDQQGGVLMSIGIRADSILLSANRIPLYAAVGLVTVLVAGGLGWLLAGPAIRPLRKLTEHTSKLGSGTETMPEVRGVREAEDLSEAMAGMLTRLAAAQRATTNSLQAAQDFAANAAHELRTPLTAMRADLDTLRIHNLPEDERDEVVADLSRAQRRVEAIITALGQLASGQLAQAEDRELIDITDMLDRVARENSRPGGPVSIDVQVADDVGLVLGWPGGLRIAVDNLVRNAITHGEATRIVLAAHRSGQMLTIVVDDNGRGLPVEEHETVLGRFRRGSTAVSGGSGLGLALVAQQAQLHGGEIQLSDGPLGGLRATLTISMSPAAEPGQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPL5</accession>
    <name>A0A132PPL5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09615</name>
        <name evidence="3" type="ORF">AWC31_05610</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847209.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24245">
        <property type="protein sequence ID" value="KWX24245"/>
        <property type="gene ID" value="AFM11_09615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09703">
        <property type="protein sequence ID" value="ORX09703"/>
        <property type="gene ID" value="AWC31_05610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5960"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="72" mass="7807" checksum="7A27D0152E5E041F" modified="2016-06-08" version="1">MFSPIDSYDGAGVVFTFGGFSVGVWVVFILAVALFIGFFVRMIQHENDAYRAIAEHKPVEPGPAAEGEPPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPN4</accession>
    <name>A0A132PPN4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4,5-dihydroxyphthalate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848285.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23992">
        <property type="protein sequence ID" value="KWX23992"/>
        <property type="gene ID" value="AFM11_11525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6381"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="327" mass="35695" checksum="A035BD5274AEC010" modified="2016-06-08" version="1">MEKLSMALGDYPHVRPLLSGEVAVDGYQVEPVEVTPIIAAYRRMIRDLEFDVCELAPTSYLMALQAGVELTGIPVFLNRRFHHADVQCGQASGVRFPADLNGKRIGVRAYTVTTGVWVRGILQNEYGLDIDNVTWVVDDEDHIEGHAPDNVERVTDGRPLGTLLSAGEIDAAFSGNAGTGRAGAPRAGWSAPADDTQTGADGPYPLFPDHEVLATDWYLRTGIYPLHSVIAIRRELVDRDPELPTALYAAFAESKRRQITADPDWSAMPRLGKQAKQIRNDPVPYGLNSNDASVRALIKFSREQGLLDPGVSDEPSGQFAKGDYPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPS3</accession>
    <name>A0A132PPS3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MspA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847501.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18630"/>
    <dbReference type="EnsemblBacteria" id="KWX24339">
        <property type="protein sequence ID" value="KWX24339"/>
        <property type="gene ID" value="AFM11_10185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6075"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036435">
        <property type="entry name" value="Leukocidin/porin_MspA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015286">
        <property type="entry name" value="Porin_fam_mycobact-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09203">
        <property type="entry name" value="MspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56959">
        <property type="entry name" value="SSF56959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453181" evidence="3">
        <location>
            <begin position="26"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="229" mass="23020" checksum="426D77C6A7EF2145" modified="2016-06-08" version="1">MLNRFAKLAAVCMLAPFAVAPLASAEPVPPPPDPAAPVADAPPPPDNGVVASAAPGVVTTPDGWTLTVAASNESQLPVAPLTTAVSSREYMVAATFTGSVSGSGESTLTGGTLDTGYQIGCGIELGQVRLIGSVGLSTSGSTLGGLIPTGLSVPLSGTLEIHLKPGTVNNVSVTKKSFKAAPVRVTIKDVHIKLDGCAGQSFLRSYAILTSSTTDTDDVVAYYGVTKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPS7</accession>
    <name>A0A132PPS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylamine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848436.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30235"/>
    <dbReference type="EnsemblBacteria" id="KWX24042">
        <property type="protein sequence ID" value="KWX24042"/>
        <property type="gene ID" value="AFM11_11810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6441"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="30828" checksum="8F3438E4E2E5B071" modified="2016-06-08" version="1">MVRMATDLTAYFKRIGFSGPARTDLDTLRAIVAAHNRSIPFENLDPLLGIPVVDLSFGALHDKLVDRRRGGYCYEHNGLLGYVLEQLGFGVDRLAGRVVWMKEPDAPLPAQTHNVLAVTVPGQDERYLVDVGFGGQTLSSPIRLAAGPVQETRHEPYRLLEHGDGLVLQAQIRGDWKPLYTFTTEPRPCIDLEVGSWYVSTYPESIFVVGLTAALITDDARINLRGRNLAIHSRGETERVRFDTAGQVLDALEGRFGIDLTDLGAHVDLKARVDEVLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPV0</accession>
    <name>A0A132PPV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10335</name>
        <name evidence="3" type="ORF">AWC31_18770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX16898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847575.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18770"/>
    <dbReference type="EnsemblBacteria" id="KWX24361">
        <property type="protein sequence ID" value="KWX24361"/>
        <property type="gene ID" value="AFM11_10335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16898">
        <property type="protein sequence ID" value="ORX16898"/>
        <property type="gene ID" value="AWC31_18770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6104"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="155" mass="17223" checksum="F23FD3B84718B2FB" modified="2016-06-08" version="1">MTDTRYVVTRTIAAPPSEVFAVLADPARHQDTEPGDWVRDAIDPQPITGTGQIFAINMFLDAAGGHYVMHNLVTDFEKDRAIEWLPGQLDESGNHDPGGWTWRYDLSPNDSGTDVTLTYDWTNTPQSFADQIGGMPPFPEEFIVESLAALDRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ68</accession>
    <name>A0A132PQ68_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_10945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847881.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19460"/>
    <dbReference type="EnsemblBacteria" id="KWX24463">
        <property type="protein sequence ID" value="KWX24463"/>
        <property type="gene ID" value="AFM11_10945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6228"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="13"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="540" mass="56492" checksum="CBCD9A49F035E4AF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ81</accession>
    <name>A0A132PQ81_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oligoribonuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orn</name>
        <name evidence="3" type="ORF">AFM11_10280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">3'-to-5' exoribonuclease specific for small oligoribonucleotides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847948.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18725"/>
    <dbReference type="EnsemblBacteria" id="KWX24491">
        <property type="protein sequence ID" value="KWX24491"/>
        <property type="gene ID" value="AFM11_10280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6094"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00045">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="215" mass="23873" checksum="4D3A40093D834DCC" modified="2016-06-08" version="1">MRDELVWIDCEMTGLDLKSDRLIEIAVLVTDADLNILGDGLDVVIHTDDEALTSMIDVVKQMHTRSGLIEEVRKSTVDLATAEEMVLDYIRGHVKQAKTAPLAGNSIATDRGFIARDMAKLDDYLHYRMIDVSSIKELCRRWYPRIYFGQPEKGLAHRALADIHESIRELKYYRATAFVPQPGPSTSEIAAIASELGPRSADATATDSAVERPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ95</accession>
    <name>A0A132PQ95_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10440</name>
        <name evidence="4" type="ORF">AWC31_18875</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX16915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847621.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18875"/>
    <dbReference type="EnsemblBacteria" id="KWX24377">
        <property type="protein sequence ID" value="KWX24377"/>
        <property type="gene ID" value="AFM11_10440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16915">
        <property type="protein sequence ID" value="ORX16915"/>
        <property type="gene ID" value="AWC31_18875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6128"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="103"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX16915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="396" mass="45015" checksum="47D6C8675C64C51E" modified="2016-06-08" version="1">MGQLSHRVDIPFPLFDADNHLYEPPEAMTKYLPKEYKDVVQYVEVNGRTKIALKGQISNYIPNPTFSVVAKPGAWEEYFKYGNPDGKSKRELFGEPMKAIPAFFEPEPRIKVMDELGVDRSLMFPTLASLIEERLSDDPVAIHVLIHALNQWLDEVWGFNYQNRIFTTPVITLPIVEKAIEELEWCVKRGARAILIRPAPVPGFRGPRSFALPEFDPFWERVVHHDVFVGMHSSDSGYSRYTSEWDGAAQEMLPFQTNAMAILNEWRPIQDAVASWVIHGALFRHPKLKVGIVEAGSKWMFPLLDSMAEVWKKAPEAFLGNPIEEIKNRIYVSPFYEEGIDDLINLIGVDQVLYGSDWPHPEGLAEPTHYVTALEHLSVEDQAKIMGGNLGRLVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQL5</accession>
    <name>A0A132PQL5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847658.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24497">
        <property type="protein sequence ID" value="KWX24497"/>
        <property type="gene ID" value="AFM11_10510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6142"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453500" evidence="1">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="128" mass="13599" checksum="9D30156482726771" modified="2016-06-08" version="1">MVAATAASAIIAGMMTAPPANAGPQACNDAYCVPGIRPNVVLGSYCDNTTYFVFGVAVAGPSIRPGRLVFCGSPRRYEPRWFRSPPMAGIRDENTPCSTELNMVAQAPDGLFLTCVPMNGDALWRRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQN9</accession>
    <name>A0A132PQN9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846332.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00115"/>
    <dbReference type="EnsemblBacteria" id="KWX24646">
        <property type="protein sequence ID" value="KWX24646"/>
        <property type="gene ID" value="AFM11_08190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5489"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="378" mass="38829" checksum="284F7E5070369DA6" modified="2016-06-08" version="1">MTVTIPTILASRPAGLIDAAQLAQQQAQTAVHQLGQGRNALADMRKGWDSAASDAASANAERAFASHRKIVDALHDMQAALQRGGDQMSATRADVAEIVGKIQPFGFEVADDGTVSIAPGSRADEMASRSPVFARQMQMLAMQYSIDLKRLIAEFDTQDNTLANALQQATGDLDLKEIARMGPAEEGKPSADDTKKDESSPAEPGKDADQTTPGATPAAVPPVPPVVAGPANPQAAPRPAAATPPPKTGGTPTQTRAAEPARPSTPAPTPPPTKGPVPAQANPTQPSRQSGPVPTAPPTTPGTPAQGSGSTATAATPASYSAAQTSSSSGAPESNIQAVSATGGLPEKIIYEIDDDGWLYPVGDPDFDPDEFDDDWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQV2</accession>
    <name>A0A132PQV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MCE-family protein MCE1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_08610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846534.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13760"/>
    <dbReference type="EnsemblBacteria" id="KWX24718">
        <property type="protein sequence ID" value="KWX24718"/>
        <property type="gene ID" value="AFM11_08610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5573"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="124"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="400" mass="42777" checksum="8DD56D1BB5FDC7B9" modified="2016-06-08" version="1">MFVDRHNPPYKAAGAVFLVVVTLVLAFIALLFRGTLEPKVQLTLLTARAGLVLDPGSKVTYNGVPIGRVTSVGTVSDDNLKARVLLDVEPRYLSLLPANVETSIQATTVFGNKYVAFRSPERPSAQRLSPTTPIDVSTVTTEFNSLFETITKITEQVDPVKLNQTLSATAQALTGLGDKFGASLVDGNAILDDLNARMAPLRRDVSGLADLGEIYAAAAPDLFAGLDDAARSAATVYDQRSDVDAALIAAIGFAGTGTDILERGGPYLQRGAEDLLPTSKLLDDYRGMIFCTIRNYHDAAPGLKAALGGDNGYSLESYGTPMGAGNPYVYPDNLPRVNAKGGPEGRPGCWQPITRDLWPAPYLVMDTGLSIAPYNHVEFGSPLFVDYVWGRQIGEPTINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRB6</accession>
    <name>A0A132PRB6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ruvB</name>
        <name evidence="9" type="ORF">AFM11_05375</name>
        <name evidence="10" type="ORF">AWC31_12750</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844971.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12750"/>
    <dbReference type="EnsemblBacteria" id="KWX24881">
        <property type="protein sequence ID" value="KWX24881"/>
        <property type="gene ID" value="AFM11_05375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18828">
        <property type="protein sequence ID" value="ORX18828"/>
        <property type="gene ID" value="AWC31_12750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4264"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="62"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX18828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="352" mass="37446" checksum="6175FEF6DFB56E0E" modified="2016-06-08" version="1">MGRFEDDDAAAEDREVSPALTVGEGDIDASLRPRSLGEFIGQPRVREQLQLVLEGAKNRGGTPDHILLSGPPGLGKTSLAMIIAAELGTSLRVTSGPALERAGDLAAMLSNLVEHDVLFIDEIHRIARPAEEMLYLAMEDFRVDVVVGKGPGATSIPLEVAPFTLVGATTRSGALTGPLRDRFGFTAHMDFYEPAELERVLARSAGILGIELGAEAGAEIARRSRGTPRIANRLLRRVRDYAEVRADGVITRDIAKAALEVYDVDELGLDRLDRAVLSALTKSFGGGPVGVSTLAVAVGEEATTVEEVCEPFLVRAGMVARTPRGRVATPLAWTHLGMRPPVTGLGQAGLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRD5</accession>
    <name>A0A132PRD5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urea ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_05510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845006.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12885"/>
    <dbReference type="EnsemblBacteria" id="KWX24901">
        <property type="protein sequence ID" value="KWX24901"/>
        <property type="gene ID" value="AFM11_05510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4292"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017778">
        <property type="entry name" value="ABC_transptr_urea_perm_UrtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482:SF4">
        <property type="entry name" value="PTHR30482:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03408">
        <property type="entry name" value="urea_trans_UrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="369" mass="38958" checksum="F3B422E72AEBBA56" modified="2016-06-08" version="1">MTILGRWQTWAGFGVAAVLLFGVAPAVLSDFRLSLLGKFLCFAIVAVGIGLAWGRGGMLVLGQGVFFGLGGYMMGMHLKIADAQIRGDDVPDFMQIAGVRELPGYWTPFASPAFTLLAILVIPAGIAALLGFGVFKRRVKGAYFAILSQALAAALAILLVGQTSIGGSNGLTNFRTFFGFTLNDPVNKQMLYFIAAATLLIVVAVVRQLMYSRYGELLVAVRDGEERVRFLGYDPANIKVVAYTLAALFASIAGALFAPIVGFIAPSQVGIVPSIAFLIGVAIGGRTTLLGPALGAIGVAWAQTLFSERFPSEWTYAQGLLFIVVVGFFPAGLAGLGVLLKRRRRAKADAPSDKVPDSDPDTEKVGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRS3</accession>
    <name>A0A132PRS3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="12" type="ORF">AFM11_06065</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845183.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29595"/>
    <dbReference type="EnsemblBacteria" id="KWX24995">
        <property type="protein sequence ID" value="KWX24995"/>
        <property type="gene ID" value="AFM11_06065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4405"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="10">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="9">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="11">
        <location>
            <begin position="259"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="635"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX24995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="700" mass="77217" checksum="D48383FE826E66DE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS28</accession>
    <name>A0A132PS28_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_07490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846901.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21990"/>
    <dbReference type="EnsemblBacteria" id="KWX24832">
        <property type="protein sequence ID" value="KWX24832"/>
        <property type="gene ID" value="AFM11_07490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5346"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="8">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="381" mass="39945" checksum="7E7315D30B477790" modified="2016-06-08" version="1">MPRLSDTMEEGVIIAWHKNIGDRVERGDILAEIETDKAIMELESYDEGILERMLAGEGDRVPIGIPIAVIGDGSGASMEPATPPPAPAPAPAAPQASGDRPKASPLARKIAAENGVDLAAVTGSGPGGRIIRKDVENLRPAETPAAPTPVEGDFDAVPLTTLQRVAAKRLTESKQTAPHFYLTAAVDVTALLAFRETVNDSLRAADGPKVSVNDFIVRAVASALRNNPGVNVSFGGDVLLHHHAVHIGVAVAVEAGLVVPVVRDADRKSVSQIAVETKEMAGRARIGKLRADEMSGGTFTISNLGMFGIEQFAAVINPPEAAILAVGAATDELRLIDGEVVARKILRLTLSADHRAIDGATGAVFLRDLTTLLENPLRIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS85</accession>
    <name>A0A132PS85_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845739.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25218">
        <property type="protein sequence ID" value="KWX25218"/>
        <property type="gene ID" value="AFM11_07350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4670"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="27"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="352" mass="37927" checksum="F3472BB85B7A1396" modified="2016-06-08" version="1">MRLAHHVIELADGHRVGISVGGSGIPLVFLHGLGLSRRSYLRLLSRVADLGFRVVAIDAAGHGETEDLPCAADEFTDRTELVLRTLDSPGIDRAIFAGHSMGGRMTIQLAAVAPDRVLAAILFNPAAGSAFDAAISSVLHSPRQMLRAVAGAAYDMYRDPFLMKVGAIARYLRMATAVTMGNTLAPTGFTGAARSLLRSGACTTLLHTLRDRAIPTIVLHGEDDAIVPFENACDIAEDANATLYRVRGACHSWLIAKPAHGADSVRQLLDGALGEALRDLAPTLGIEDWRDVRAWDEVLIEPDARVRDMCGRRVVLGYLERERVEMNLVRRAVLQDVLAASAPRLLGHARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSG5</accession>
    <name>A0A132PSG5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05870</name>
        <name evidence="2" type="ORF">AWC31_11730</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000002">
        <property type="protein sequence ID" value="ORX19234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845131.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24962">
        <property type="protein sequence ID" value="KWX24962"/>
        <property type="gene ID" value="AFM11_05870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19234">
        <property type="protein sequence ID" value="ORX19234"/>
        <property type="gene ID" value="AWC31_11730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4365"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX19234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="71" mass="7671" checksum="83A9EB80BC93EB71" modified="2016-06-08" version="1">MTDRRDAREQALRVLPLPYSLALRLRDAGVAPEVVSEYLSVDESALDGFYRIAEAKLAAALPSSPAEVDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSH5</accession>
    <name>A0A132PSH5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="9" type="ORF">AFM11_05920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845147.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11780"/>
    <dbReference type="EnsemblBacteria" id="KWX24972">
        <property type="protein sequence ID" value="KWX24972"/>
        <property type="gene ID" value="AFM11_05920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4375"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="270" mass="26967" checksum="0A8C451E665B6323" modified="2016-06-08" version="1">MAGFGQRLADAVSARGPLCPGIDPHPELLRAWGLTTDASGLAAFCDICVTAFADFAIVKPQVAFFEAYGSAGFAVLERTIAALRDAGVLVLADAKRGDIGSTMAAYAAAWAGDSPLAADAVTASPYLGFGSLQPLLDTAAERGRGVFVLAATSNPEGASVQRAVAGARTVAQSIVDSVSEVNHAANDAMGSVGVVVGATVTEPPDLSTLGGPVLVPGVGAQGGRPEALGGLGGAKTLLPAVSREVLRAGPAVGDLRAAAERMRDAVAYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSK6</accession>
    <name>A0A132PSK6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_03405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844006.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21745"/>
    <dbReference type="EnsemblBacteria" id="KWX25341">
        <property type="protein sequence ID" value="KWX25341"/>
        <property type="gene ID" value="AFM11_03405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2555"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="259"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="464" mass="50266" checksum="2C38CCD416681654" modified="2016-06-08" version="1">MAFDITPTAAQHDLARRTHEFAEQVIRPVASDYDRRQEFPWPVLEEAAAQGFYSPLFYRDLIGDPTGLSLPMFMEELFWGCAGIGLAVVMPALALSAIGQAASPEQMLQWAPECFGTPGDLKLAALAISEPEGGSDVRNLRTRAVRDGSGPDADWIINGHKMWIGNGGIANVHVVNAVVDEQLGHKGQALFIVEGGTPGLEMVRKLDKLGCRASHTAELKFTDVRVPADHLLGGHEKLERKLARAREAIEGARHSGSATLGTFEQTRPMVAAQALGIARAAMEYATEYANRRVAFGGPIIDNQGIAFPLADLATQLDAARLLTWRASWMAATGVPFDRGEGSMSKLAASEVAVRTTERAIQTMGGWGYVTDHPVEKWYRDAKLYTIFEGTSEIQRIVIAHALGAADGKPPLHVDLEPSGGPLNRWFGRGTPLRTRAANAALSAKDNVPTPVMRLAMKALRPPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSN5</accession>
    <name>A0A132PSN5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843872.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21920"/>
    <dbReference type="EnsemblBacteria" id="KWX25305">
        <property type="protein sequence ID" value="KWX25305"/>
        <property type="gene ID" value="AFM11_03175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2509"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019923">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03621">
        <property type="entry name" value="F420_MSMEG_2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="29270" checksum="34C26409C07A165B" modified="2016-06-08" version="1">MPNDFRFGVSLRTAESQAQVTDAARRAEDFGFGVINVPDHLGAPAPFPTLTAAATATSTLRVGTFVLNACFYKPALLARDVEALRDLSGGRLDLGLGAGYVREEFEAAELPFPGARERIAYLRHVTEHIKEHLTDVPILIAGNGDRLLTVAAETADIIGFTGGDHVDGDPLAERITFVRNAAGDRFSDLELNIAITAMPAVGEEMPNLSIPRHFLPGLPDEQLLRHPGVLSGSTTAIADRLRELRETYGISYFIVQAAHSEAFAKVIAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSR5</accession>
    <name>A0A132PSR5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_03705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844155.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21450"/>
    <dbReference type="EnsemblBacteria" id="KWX25388">
        <property type="protein sequence ID" value="KWX25388"/>
        <property type="gene ID" value="AFM11_03705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2617"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453558" evidence="1">
        <location>
            <begin position="31"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD_N" evidence="3">
        <location>
            <begin position="58"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="2">
        <location>
            <begin position="163"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="534" mass="58060" checksum="5CCA21018309E4BB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSX5</accession>
    <name>A0A132PSX5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_04095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844362.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21060"/>
    <dbReference type="EnsemblBacteria" id="KWX25446">
        <property type="protein sequence ID" value="KWX25446"/>
        <property type="gene ID" value="AFM11_04095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2697"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="284"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="459"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="519" mass="56007" checksum="04B8915A758FCB88" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT16</accession>
    <name>A0A132PT16_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844359.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21065"/>
    <dbReference type="EnsemblBacteria" id="KWX25445">
        <property type="protein sequence ID" value="KWX25445"/>
        <property type="gene ID" value="AFM11_04090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2696"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="35"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="32317" checksum="D4E41A2DBF04B7EF" modified="2016-06-08" version="1">MSTPWHRGAAAVATLTFDVDAETPILAQGRRYADHMMTMSHQSYGPDVGVPRILDMLDELQVLATFFVPGWVAEQRVGLAASIVERGHEVAHHSYSHRSPVTMTAAEERADFERGMEVFGKQDIDIRGHRAALWGASWQTLSLIAEYGLSYDSSLMGDDRPYRINTDVAPIVELPVHWSLDDWEQYAYLPDPHVGSVIESPVKVAEMWRAELDGMRRYRCLFNLCVHPFLSGRPGRIIALRGVIEHALELGDVRFARCRDVAEAVDGDRAIQPRTLRPPVAQADVYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT73</accession>
    <name>A0A132PT73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mechanosensitive ion channel protein MscS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_03780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844195.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21385"/>
    <dbReference type="EnsemblBacteria" id="KWX25397">
        <property type="protein sequence ID" value="KWX25397"/>
        <property type="gene ID" value="AFM11_03780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2632"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="413" mass="45421" checksum="5495471F80A0A497" modified="2016-06-08" version="1">MPETIELESATHFAITAAWVAAAVALAYGVGLMLSWVMQRLGRRSAVLRDVAQLTRRPVRATLMVIAATVALQRTSDAQASWRGWLDHILVIALIATITWLVASLVVVAERRAIARFAGGDTGLTDADRHWRKIRTQVTVLRRIVIAIVAVLGAAAALMTFPSFSDIGKTLFASAGVLSVVAGLAAQTSLGAAFAGIQIAFSDAIRVGDVVVLEKEWGRIEEITLTYVVVHLWDERRLVLPCTYFTTTPFQNWTRNATELLGTAELDVDFTVPLDEMRAELDRLLRANPLWDERVGVLQVTDAVGGLVRVRMLVSASNAGALFDLRCDVREGMVEWLQRTHPGALPRQRLEIPREQPVELPRRTTTVGRPQADSGLFTGNPEAERRGRAFDQSESDAPGRTDRELVRVPYADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT74</accession>
    <name>A0A132PT74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844417.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20955"/>
    <dbReference type="EnsemblBacteria" id="KWX25464">
        <property type="protein sequence ID" value="KWX25464"/>
        <property type="gene ID" value="AFM11_04200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2717"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453574" evidence="1">
        <location>
            <begin position="27"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="SLT_2" evidence="2">
        <location>
            <begin position="160"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="243" mass="25826" checksum="50FE9F42978A24CE" modified="2016-06-08" version="1">MSPVRWLRAVAVIAATALLMASSCSWQLGTPIPEGVPPPAGDPVPQIDTYAKGRPADALREWAAERAPALGMPVNALEAYAYAARVAEVENPNCNVKWTTLAGIGMVESHHGTYRGAMVAPNGDVSPPIRGVQLDGTAGNLRIADTDGGKLDGDDELDRAMGPMQFIPETWGHFGVDANNDGKVSPDNFDDAALSAAGLLCWNGKDLSNPRGWMKALKAYNNSEQYARAVRDWATAYSSGHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTC1</accession>
    <name>A0A132PTC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_04970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RuBisCO large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25588">
        <property type="protein sequence ID" value="KWX25588"/>
        <property type="gene ID" value="AFM11_04970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2875"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033966">
        <property type="entry name" value="RuBisCO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020878">
        <property type="entry name" value="RuBisCo_large_chain_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000685">
        <property type="entry name" value="RuBisCO_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036376">
        <property type="entry name" value="RuBisCO_lsu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017443">
        <property type="entry name" value="RuBisCO_lsu_fd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704">
        <property type="entry name" value="PTHR42704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00016">
        <property type="entry name" value="RuBisCO_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02788">
        <property type="entry name" value="RuBisCO_large_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00014">
        <property type="entry name" value="RuBisCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51649">
        <property type="entry name" value="SSF51649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="SSF54966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00157">
        <property type="entry name" value="RUBISCO_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_large_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RuBisCO_large" evidence="5">
        <location>
            <begin position="138"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="416" mass="44152" checksum="64242E4D814C0EDA" modified="2016-06-08" version="1">MLLNDTIVVTYRILSYLPLDQAAEAIAGEQTTGTFTKVAGETPELHRKHRAQILDMTPLEGDLGGPLPGARGRESGSLRGGLVRIGYPLANSGPSLTRMLAFVSGNLYELSELAGIKLLDIDFPEQFGAVYPPAPHGVAGTRRLVDRPRGVLLGTIVKPNIGLTGPDYYRVVRELGMAGLDFIKDDEVNADCPPSPLRQRVPHVIRALDEVESETGRRPLYAFNISDELDHMLDSASYVAEAGGKCAVVNTALVGIPALCAVRRQTDLVIHGHLAGFAAASRHPNLGMGYAAFQKLARFAGADHLHVGGFRSKFFIEDEETAANVEAVRTPLLGGRECLPVISSAQWAGTAPTTWQHTGTDDLLVLAGGGVLGHPGGAGAGARSMRQAWDAVTAGISLDEAAKEHRELAAALAHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU08</accession>
    <name>A0A132PU08_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_00525</name>
        <name evidence="4" type="ORF">AWC31_33640</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842284.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33640"/>
    <dbReference type="EnsemblBacteria" id="KWX25816">
        <property type="protein sequence ID" value="KWX25816"/>
        <property type="gene ID" value="AFM11_00525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11630">
        <property type="protein sequence ID" value="ORX11630"/>
        <property type="gene ID" value="AWC31_33640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.108"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="245" mass="26515" checksum="433C2BABBE84D163" modified="2016-06-08" version="1">MTRFGVPHGVDPVEPDRYATWDAAYVLGSLDSNERREYETHLAGCAQCRAAVAELSGMPALLAMLELDDVRALDEAEPEPPLRPEVLQSVLNKVSSRRRRSRWITSGAVGLAAALLAVGMVIAIRPEIIGLQRGAEQQQTAQMLEMTKVSQTPINASIAMTSYGWGTRIDMACTYGDWGRRDAPPQNLGMVVVGRDGSREEIATWLGLSGATALPSGNTQKPMEEIAAVQMVSSPDGKVLLEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU41</accession>
    <name>A0A132PU41_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842335.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33730"/>
    <dbReference type="EnsemblBacteria" id="KWX25833">
        <property type="protein sequence ID" value="KWX25833"/>
        <property type="gene ID" value="AFM11_00620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.127"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="17691" checksum="6544C795DAA7A4FA" modified="2016-06-08" version="1">MPTSPDLQLAAERLGLVLTSHGMQRMTARVLATLLFTEQTSVTMSDLAESLEASAGAISGALKMLTSVGLAERVPAPASRRDHFRLRDNAWAILFTNQNETISAMQAAAEAGIEATDSRSPAHQRLTQMRDFYAFLMAEIPTLLERWNQLSNNQTSENARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU89</accession>
    <name>A0A132PU89_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_01075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842573.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25911">
        <property type="protein sequence ID" value="KWX25911"/>
        <property type="gene ID" value="AFM11_01075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.221"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453304" evidence="2">
        <location>
            <begin position="30"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="141" mass="13561" checksum="663442B39A95F3EC" modified="2016-06-08" version="1">MKSTIKRVTVGAAFGGALFLSAGMGIANAQPNDGQVDLALGTAGVLEDVPIGSAAQIAAGVCDGEVAQVTTVAQNVDASGTQQNVCNNNVGAVEFKQNEGAPAEGAAEQPEGAAEGSEGSGTAEETGSAPAPAEEGSGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU97</accession>
    <name>A0A132PU97_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844761.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25622">
        <property type="protein sequence ID" value="KWX25622"/>
        <property type="gene ID" value="AFM11_05165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2914"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="502" mass="53205" checksum="271D3C201638C53F" modified="2016-06-08" version="1">MSAAIATLTAAAAVRRACGRRMPDNPADLARLLIPGYVVTPTIKLLSDELVRAVEQPDSRLILTMPPRTGKSVLTSQVFPVWLLARDPDAEIIVKSYGDALAEEHSAAARRLIAENPGVVGIELAPDKQAVGRWRVAGHRGGMLAGGILSATTGFGANCLLVDDPIKGAAEADSDAYRRRLNAEFKASLMTRLMPGASAIVVLTRWHEEDLAGALLGEPGSRWRVVNVPAISTAGVPDALGREHSGVAMTSALGRTVEQFREIEHEVGSRAWAAMYLGVPATPQGGLIRSAWLDQWRLPAAPSGAVKIVVGVDPADSGEGDETGILAASLTGERVVALIADASGRMTSDAWAVRAVQLAVDVGASEIAIEAFAARETYTRLVREVLARMRPDRPIKITGWPPKGSGRGQGDAVARSSGMLAAMETGRCRVAGHLPDFEAQAVTWEAGQHQPDRVAAAVVAFDVLDHSHGQAWGFVSPLDTERRAREGTITAIPAYLRRRVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUB3</accession>
    <name>A0A132PUB3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplM</name>
        <name evidence="7" type="ORF">AFM11_01065</name>
        <name evidence="8" type="ORF">AWC31_34100</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842570.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34100"/>
    <dbReference type="EnsemblBacteria" id="KWX25910">
        <property type="protein sequence ID" value="KWX25910"/>
        <property type="gene ID" value="AFM11_01065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11709">
        <property type="protein sequence ID" value="ORX11709"/>
        <property type="gene ID" value="AWC31_34100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX11709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="147" mass="16229" checksum="298A9FD042CF6EAD" modified="2016-06-08" version="1">MPTYTPKAGDTTRSWYVIDAQDVVLGRLAVEAAKLLRGKHKPTFTPNVDGGDFVIVINAEKIAVSGDKLTNKFAYRHSGYPGGLRKRTIGELLEKHPTRVVENAIVGMLPHNKLGRQIQKKLKVYAGPDHPHAAQQPVPFEIKQVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUN0</accession>
    <name>A0A132PUN0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_00865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842459.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33900"/>
    <dbReference type="EnsemblBacteria" id="KWX25877">
        <property type="protein sequence ID" value="KWX25877"/>
        <property type="gene ID" value="AFM11_00865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.179"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="168"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="350" mass="36011" checksum="C474DD6E79F60BD9" modified="2016-06-08" version="1">MATATGPAKLNRTSADNHFRLGLLLAVSSALAFGSSGPFAKALMEAGWSPTAAVTARLAGGAVAMAVFATIVRPGWIREVTRHAKTVVAYGLIPIAGAQLCYYNAVAHLSVGVALLLEYTAPILVVGWLWATTRRRPSAMTFAGVALAVAGIMLVLDVFSGAHINVVGVTWGLAAAICAACYFMMSNQASTDGAGLNPISLATGGLIIGTTGVALLGFTGVMPLAFTTNSVDIAGFTTSWLVPVIALGLIPTAIAYTLGILSISRLKPRFASLVGLSEVMFAVLIAWIMLGEAITPIQALGGVVVLAGLALARQGDRSEQEAERSSAVSEACWPDNPAQNVTGEQTISRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUX2</accession>
    <name>A0A132PUX2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_02435</name>
        <name evidence="6" type="ORF">AWC31_35215</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843260.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35215"/>
    <dbReference type="EnsemblBacteria" id="KWX26115">
        <property type="protein sequence ID" value="KWX26115"/>
        <property type="gene ID" value="AFM11_02435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11893">
        <property type="protein sequence ID" value="ORX11893"/>
        <property type="gene ID" value="AWC31_35215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.499"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="154" mass="16687" checksum="04025278AEAB296D" modified="2016-06-08" version="1">MGEPDEQPLDGIDRILVRELVADGRATLAHLASVAGLSVSAVQARVRRLESRGVVTGYAARLNPEALGSMLSAFVAITPLDPSQPDDAPARLEHIPEIESCHSVAGEESYILQVRVASARALEDLLQRIRTAANVRTRSTVILQTFYTGRDYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV10</accession>
    <name>A0A132PV10_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UsfY protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843372.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35430"/>
    <dbReference type="EnsemblBacteria" id="KWX26153">
        <property type="protein sequence ID" value="KWX26153"/>
        <property type="gene ID" value="AFM11_02655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.545"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="102" mass="10957" checksum="0074813AD08D1F4D" modified="2016-06-08" version="1">MKGPKDPVDHARTTRPHAGESMKDNVIMPALIVIGLALVLFVGCLAAFASGHPDVGFTIGGLSAVGFVIGSLWLALEHLRVRRIEDRWYADHPGVMRQGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV78</accession>
    <name>A0A132PV78_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843099.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34930"/>
    <dbReference type="EnsemblBacteria" id="KWX26067">
        <property type="protein sequence ID" value="KWX26067"/>
        <property type="gene ID" value="AFM11_02150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.441"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="24688" checksum="366CF51427C44BE2" modified="2016-06-08" version="1">MELSGYRALVTGGTAGIGLACAELLASEGATVTITGRDAQRGESAAAKLGDNVNFVQADLSDIESVKSLARECDGVDIVVNNAASFPGALTVDQDVESFERTFDTNVRGTYFLVAALVPAMLKRGNGSIVNVTSMVASKGVPGASTYSASKAAVESLTRTWAAEFGSQGVRVNSVAPGPTKTEGVEAEWGDTNEELGRALPLGRTARPEEIAHAVLFFCSPRSSFITGSTLHADGGGAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVA0</accession>
    <name>A0A132PVA0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843752.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35365"/>
    <dbReference type="EnsemblBacteria" id="KWX26289">
        <property type="protein sequence ID" value="KWX26289"/>
        <property type="gene ID" value="AFM11_02590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.531"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="335" mass="34812" checksum="0F08021B103ED177" modified="2016-06-08" version="1">MVARLDSAGDVLITGPAVRAVAAANGPVTFLAGPRGRAAAELLPGVGDIVEWQAPWVDFDSPEVTAGHVDALVKQLRDIAPDRVFIFTSFHQSPLPLALLCRMADVGWVGAISEDYPGTLLNLRHHVAGGVPEPERALSLVRAAGFDLPAHDDGSLMVRTPPPLSGELARKVGSKPFVAFHPGAAVPARRPTAARSAGMVRTLTRAGHRVVVTGDEHERELTAQVAAGVAVDLGGDTTLATLASVFAQAGVVIAPNTGPAHLAAAVGVPVVSLFAPVVPAEQWSPYARNVIRLGDQEAPCQLTRARTCPVPGHPCLDGITDAELLAAVDRLGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVE5</accession>
    <name>A0A132PVE5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_01740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842896.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26002">
        <property type="protein sequence ID" value="KWX26002"/>
        <property type="gene ID" value="AFM11_01740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.358"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="316" mass="35130" checksum="3609759B5C79C661" modified="2016-06-08" version="1">MTGVTESTRAAGPSELDDVSDRTEPIPMVTPGREHPSKRRPADGLPGIGWLVCGVVGSAAIAWFIFLGPGELGSKSEWFFGAVVFVVVMVTMWQTLNIARLARQDAADAAERLRRELAAADERSALELALTQKWHRAEMESQQKLHRAELAAQQELARVERGHLLEQLQKQAMIEVSRSIGAHTRMLATLWSEGARCLHLDDRDEREKAMNVIFEQISHVVTDVSVELDNAHLLSQDDRLHLALDRVNEAVLMAIQVAEDVHASVVDGRKPKSNPIPAVQRLLHERATEARRLAWSLLRTGLEDSKFRAEDPSATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB43</accession>
    <name>A0A132PB43_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859764.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19555">
        <property type="protein sequence ID" value="KWX19555"/>
        <property type="gene ID" value="AFM11_35285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5787"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="390" mass="41806" checksum="44CFC19B8487A93D" modified="2016-06-08" version="1">MSPHPRDRDLESDLAEQLGFLASSASAFDLGQLPESKRIALVIRVLVHDTNISHSLLDQLGIKNSLSWADSTPAIDRDPNIVGRSPGLTTMGPGPTGMVFRPRYFEQIEQSPTTRYVPFTDWWERAVILDGNGNEFSRKSLVLAMTNKDGGAHIDRLNAAMYDFIHSNSAGFVSISVPEPGSPGGAAEPVPTPVYASIRTIAEELLLTLQRSGRQVPRSTVVPELGMIDSFTAGDHTGNVLEPDLSREDASHTSIQFGSLPGVTFRLSRLQSAQSDPAFDGEIPAGWLAIVGTRDSSGEVVHQSGGAGPTETDTAPPDVPHDFEIPAANDMVTFGFDNFPQATFTATRASTEQVTESPWGKSVRGAGWIELFITLNGATWPLSGFAGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBA9</accession>
    <name>A0A132PBA9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_35370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000043">
        <property type="protein sequence ID" value="KWX19537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859787.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19537">
        <property type="protein sequence ID" value="KWX19537"/>
        <property type="gene ID" value="AFM11_35370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="85"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="29290" checksum="2481E5DA671CDFB1" modified="2016-06-08" version="1">MQGMRSTETEDGSKYGPPPQYPIESVDNALRLLLLFETQPSIRLTDASTYLGVASSTAHRLMGMLLYRGFVRQNPATRAYEPGQALSSIAFAIRRQVDIRTLARPVLERIFEQTGETVHFARLERTDVQFIDAIESRRAVRVGSRQGLTLPANCTATGKAMLSLLGEKQLRNLYPGQELPKLTTNSITSRSDLERELDEIRHRGYANSREESEDGVTSVAAAVAGPSGTVYGINVSVPAHRMSEELRSDLGGMLRAAAEELQGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBB0</accession>
    <name>A0A132PBB0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_34975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859595.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02045"/>
    <dbReference type="EnsemblBacteria" id="KWX19600">
        <property type="protein sequence ID" value="KWX19600"/>
        <property type="gene ID" value="AFM11_34975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5724"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="352"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="396"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="618" mass="66159" checksum="CC9E5098E49DA0DF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-12-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBD6</accession>
    <name>A0A132PBD6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859476.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19626">
        <property type="protein sequence ID" value="KWX19626"/>
        <property type="gene ID" value="AFM11_34790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5307"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043755">
        <property type="entry name" value="DUF5701"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18959">
        <property type="entry name" value="DUF5701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="238" mass="24969" checksum="118C58FA29F47E1A" modified="2016-06-08" version="1">MHRWGRVPNTAQPPTSTATAILPSPLEQAERLVSLGLHTAAGLGAPALRAAAGASGDPRALLVLHPDLISVRTLAPLLTVNARPGFVVSDMDDVDEFTAIDSVTVPDRPAYLISDLDRGDAMANWSPDEALPAITAAGRTPLTLTEGVYWVLQQPDVLQRGHCFMTIGSRRRKPDGTTDARTPALWISNGTGRDGPGNRNAPKVGWCWAGNRHTWLGFASAGARTAGAGGGDNSTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBF1</accession>
    <name>A0A132PBF1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome D ubiquinol oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_34490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859293.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17305"/>
    <dbReference type="EnsemblBacteria" id="KWX19650">
        <property type="protein sequence ID" value="KWX19650"/>
        <property type="gene ID" value="AFM11_34490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5243"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX19650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="333" mass="34681" checksum="5B3DACC17215C728" modified="2016-06-08" version="1">MTLADVVAVAMFVGVIAYGLFGGADFGSGFYDLTAGRGEMAGELRELVDHSIGPVWEANHVWLIYILVIWWTGFPRSFAAATTTLFIPLILALAGIVLRGASFVFRKYAATYRQARLFGAIFAGSSLITPFFFGTVVGALASGRVPAGGYGDRIGSWVNPTSFVGGAFAMATCVFLAGVFLTADAQRSGADALAERLRIRTIAVGIVAGAIVFAGLYPVTHDAPILSSGLRGAAAPLLVIAAVAGVATLALLYLSRFSIARIPAAGAVAAVIAGWGVAQYPWMLVGQMTIAQAAGAHPTMVGLLVVVGVACVLVLPALGYLLWLTQTEVWSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBH7</accession>
    <name>A0A132PBH7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859411.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22265"/>
    <dbReference type="EnsemblBacteria" id="KWX19683">
        <property type="protein sequence ID" value="KWX19683"/>
        <property type="gene ID" value="AFM11_34700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5287"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013207">
        <property type="entry name" value="LGFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08310">
        <property type="entry name" value="LGFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452994" evidence="1">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="20668" checksum="1DFEE3BF7D189496" modified="2016-06-08" version="1">MRTIAHRRTAVVGLAAVALITVGCSNGQGIDASQSPQVGLIATSTEVPPPPAEVKLIGERDVEVTLTGPIAVKYSSATQSQKDALGKPLTGDFNAGARESGVLFQQFQGGVITAKNGDVGTPAYITWGKIREAWNIPRDPDGVPAITGENGSVGPLGAPTSDENPVGDLLVETFDHGQIAFNTKTGDVEVTVNGKVVPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBQ7</accession>
    <name>A0A132PBQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_33955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858988.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32495"/>
    <dbReference type="EnsemblBacteria" id="KWX19759">
        <property type="protein sequence ID" value="KWX19759"/>
        <property type="gene ID" value="AFM11_33955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5128"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453127" evidence="2">
        <location>
            <begin position="31"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="43"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="128"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="420" mass="43504" checksum="BD70A6FD837508AB" modified="2016-06-08" version="1">MDRDRMRRARVVLALTACLVVSGCATEGLASLPLPAPGVGSGGYRVTAVFSNALNLPANAKVKLAGADVGQMESMVARNYTAVTTLRIMDGVRLPQGSTAELRSATPLGDVFVAIKPPSPTDPDAPLLKDGDTIPLESTAAAATVESVLSSAAVLVNGGAVRNFTNIINGLGKATGDQGQAFGNLIRKTNQTLGTLNGRSEQISTAITETSLLVEQLEAKNQTISEVMAQARPATDTLAAHTTQIADLVEQVGDVSDQLRKFPSIAGTDTSGRSVIADANTVAGAWNDVVLTPDATLYALNRLMPPLVKGTTSNAIAVNASIDRLILGHIPDIGFAGDPGLHGPKWHNWHQLVGAFRYTLLRLQEKVVGRGPAVPQVPVIPSPTEPGQLEVAPHAGGPVPAAPPPEPAPVPGPLPAEAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCR3</accession>
    <name>A0A132PCR3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858232.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19715"/>
    <dbReference type="EnsemblBacteria" id="KWX20123">
        <property type="protein sequence ID" value="KWX20123"/>
        <property type="gene ID" value="AFM11_32580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4844"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="339" mass="33617" checksum="24CE4B34342A09DE" modified="2016-06-08" version="1">MGSITDVGGIQVGHHHRLDPDAALGSGWASGTTVVLAPPGTVGAVDGRGGAPGTRETDLLDPINTVRHVDAVVLTGGSAYGLAAADGVMTWLEEQGRGVAMDGGVVPIVPSAVIFDLPVGGWSCRPTAEFGRAAAEAAGTEFALGTVGAGVGARVGVLKGGVGTASVTLASGVTVGALVVVNAAGDAVDPATGLPWMSEYVEEFGLIAPPADQLAGYADLRSELSPLNTTIAVVATDAALSPAACRRVAVAAHDGLARTIRPCHTPLDGDTVFALATGAITVPPDPRTPVAMSPETVLVTQVGAAAADCLARAVVVGLLAAESVAGIPTYRDMLPGAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDA1</accession>
    <name>A0A132PDA1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857658.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26360"/>
    <dbReference type="EnsemblBacteria" id="KWX20300">
        <property type="protein sequence ID" value="KWX20300"/>
        <property type="gene ID" value="AFM11_31735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4251"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="446"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="540" mass="58592" checksum="0B1FE77DF437FFF2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDD9</accession>
    <name>A0A132PDD9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_31670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857709.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26290"/>
    <dbReference type="EnsemblBacteria" id="KWX20314">
        <property type="protein sequence ID" value="KWX20314"/>
        <property type="gene ID" value="AFM11_31670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4238"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="398"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="487" mass="52118" checksum="201D23CE85187D52" modified="2016-06-08" version="1">MSESLVDLLAGLRGRGDHPLLICDDTRISSAEAEVRSARLARGLVALGAGKGIHVGLLYPNGVEFVVAMLAAARIGAVVVPFSTFLTSAELRTQMLDSDVVIMLSSRHFRNHDYEERLAEVGDAPCLRHVLFELPEADEPDIAGLEADVDCCDPMAIIYTSGSTGAPKGVVHSHNGLLAHQRNLNAIRGLSAADRLFCNSPFFWVGGFAFGLLATMVAGATLICSNASDAGATLDLLESEKPTLTNGFAAGIAHLTRHPSFAHRDLSSMRRGNLYPIMTPDARPADPELRHNMLGMTEAGSVVLIDADDSDQPEHRRGSYGRPAPGFETKVLASGELCIRGPYVMLGYHGRNREDCFDADGWFHTGDLVRVDDEGFYYFLGRAGAMIKTAGANVTPGEVEKALVKLLGCGAVHVIGLPDAERGQVVAAVIVMDDPSTFDEAAIRTALRDELSAYKVPKRFAVIRPAQLPVLSSGKVDMARLAGLFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDF3</accession>
    <name>A0A132PDF3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-rhamnose mutarotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858334.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32310"/>
    <dbReference type="EnsemblBacteria" id="KWX20002">
        <property type="protein sequence ID" value="KWX20002"/>
        <property type="gene ID" value="AFM11_32865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4902"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="113" mass="13240" checksum="67903147DDB8541A" modified="2016-06-08" version="1">MTVPTTPKTQRVCFLLQLRPDRMDEYLTIHEKVWPEMLGALTAAGWRNYSLFVRESDGLVVGYLETDDFALAQKRMAETDVNARWQAEMAEYFVSGDKPDEQMRPLFEYFHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDT6</accession>
    <name>A0A132PDT6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856939.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20495">
        <property type="protein sequence ID" value="KWX20495"/>
        <property type="gene ID" value="AFM11_30475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3994"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452985" evidence="1">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="99" mass="10512" checksum="0B04C2DC0C072650" modified="2016-06-08" version="1">MNKALMAAITGSCTVLLLASPANQAAAAPAGPGSVQDTVSMLESRGYKVIMNKTGSAPLERCTVGAVRPGRDVTELRKNVRERTVERVVYKTVYLDVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDV3</accession>
    <name>A0A132PDV3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenic transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_30335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856870.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00670"/>
    <dbReference type="EnsemblBacteria" id="KWX20474">
        <property type="protein sequence ID" value="KWX20474"/>
        <property type="gene ID" value="AFM11_30335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3965"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="369" mass="40097" checksum="4F3305B8C4F6B669" modified="2016-06-08" version="1">MTDTTTTAAPPVVGKLSTLDRFLPVWIGAAMVAGLLLGRWIPGLNSALESVAIDGISLPIALGLLIMMYPVLAKVRYDRLDTVTGDRKLLLSSLVLNWVLGPALMFALAWLLLPDLPEYRTGLIIVGLARCIAMVIIWNDLACGDREAAAVLVALNSIFQVIMFAVLGWFYLSVLPGWLGLQQTTIDTSPWQIAKSVLIFLGIPLAAGYLSRRLGEKTKGRDWYETKFLPRIGPWALYGLLFTIVILFALQGDQITHQPWDVARIALPLLAYFAIMWGGGYLLGTLLDLGYERTTTLAFTAAGNNFELAIAVAIATYGATSGQALAGVVGPLIEVPVLVALVYVSLALRKRFHHHTSQHLPTTGSTRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE29</accession>
    <name>A0A132PE29_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856564.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25150"/>
    <dbReference type="EnsemblBacteria" id="KWX20596">
        <property type="protein sequence ID" value="KWX20596"/>
        <property type="gene ID" value="AFM11_29810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3854"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="25"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="251" mass="27729" checksum="3B35045A312771D9" modified="2016-06-08" version="1">MSHPTAYPQARTVADFTHNLREVGERIEAALQRAGREPGDVRLLPVSKTVDEDRLRLAAAAGRTMFGENKVQEAKRKWRNLSDLDVQWSVIGHLQTNKAKDVAEFAAEFQALDNARAAQALDRRLQTLGRSLDVFVQVNTSGEDSKYGLAPDDVIGFLRTLPNCSALRVRGLMTIAVLSSDVERIRPCFALLRKLRDHARELDVVGRGELSMGMSGDYEVAIEEGATCVRVGQAIFGARATPDSHYWPASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE72</accession>
    <name>A0A132PE72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_30310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20527">
        <property type="protein sequence ID" value="KWX20527"/>
        <property type="gene ID" value="AFM11_30310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3959"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453180" evidence="6">
        <location>
            <begin position="29"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="231"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="553" mass="55928" checksum="DCE1DD68DA53BB22" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE76</accession>
    <name>A0A132PE76_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_29605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856693.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24945"/>
    <dbReference type="EnsemblBacteria" id="KWX20638">
        <property type="protein sequence ID" value="KWX20638"/>
        <property type="gene ID" value="AFM11_29605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3812"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="56"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="349" mass="38678" checksum="C153DFC59AAC2C19" modified="2016-06-08" version="1">MPPPTDAEYFDLGDFTLQSGFTLRNARLAYKTYGTLNDDKSNVIVYPTWYSGWHTDNEWLIGTDKALNPDEWFIIVPNMLGNGLSSSPSNTPAPYDRARFPAVTFYDQVEAQHKLVTEKFGISTIALVTGWSMGAGQTYQWAVSHPEMVQRAAPFCGSSITAPHNKVFLESLICALTADAAWADGDYSPEALPIKGLRAFARVYSGWGFSQAFYWEETWRELGFTSFDDFLYGFWENFFRDGRDPNNLIAMLRTWHSGNVGNTPGFGGDVEKALASIKCPLLAMPAEKDLYFPPEDEQWASQFIAHGEVRVIPGVWGHFAGGGANPVDTAFIDAGIRDLMSKPGYSPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEA9</accession>
    <name>A0A132PEA9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20676">
        <property type="protein sequence ID" value="KWX20676"/>
        <property type="gene ID" value="AFM11_29045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3691"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="275" mass="29118" checksum="FE2B6D32D08C75DB" modified="2016-06-08" version="1">MFISGASRGIGLAIAKKAAADGANIVLVAKTADPDPKLEGTVYTAAKEIEEAGGQALPIVGDVRDGDAVASAVDQAVAQFGGIDLCVNNASAINLGSIEEVPLKRFDLMNGIQIRGTYAVSQACIPHMKGRENPHILTLSPPLRLESEWLKPTAYMMAKFGMTLCALGIAEEMREAGIASNTLWPRTLVATAAVQNLLGGDEAMGRARKPDVYADAAYTIFNKPAREYTGQSLLCEDVLLDNGVTDLSVYDCVPGSDLGVDLWVDTPNPHGYIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEV1</accession>
    <name>A0A132PEV1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856214.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32895"/>
    <dbReference type="EnsemblBacteria" id="KWX20804">
        <property type="protein sequence ID" value="KWX20804"/>
        <property type="gene ID" value="AFM11_28665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3614"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="158" mass="17857" checksum="B012893E53E48A1D" modified="2016-06-08" version="1">MCYAYNVPRYNRLDELLVRVHTVRQRPGWRRRLIDAATTVPTLSTLRVLRAVEQREKSGHGASIGEVAEYMGVEHSTASRTVTSAVTAGLLTKTLSTEDQRRCVLMLTDRGRDALAEVTSRRRDMVAETVAHWSDDDVDTLVDLLERLVTDFERKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF35</accession>
    <name>A0A132PF35_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_28165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855876.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10715"/>
    <dbReference type="EnsemblBacteria" id="KWX20948">
        <property type="protein sequence ID" value="KWX20948"/>
        <property type="gene ID" value="AFM11_28165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3508"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="26378" checksum="27DEA4BB4BD069F2" modified="2016-06-08" version="1">MALQPVNRRSVPEDVFDQIISEVLSGEMQPGESLPSERKLAEVLGVSRPAVREAIKRLTAAGLVEVRQGDATTVRDFRRHAGLDLLPRLLFRAGELDISVVRSILETRLHNGPKVAELAAQRRQPEMPDLLNETLGALESEPDPIEQQRHAMTFWDHVVDGADSIAFRLMFNTLRETYEPVLPALATLMAEEVGRPEAYRRVADAIAAGDTAAARQAAHELLEPATGALLGALEALEENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFA5</accession>
    <name>A0A132PFA5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856013.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10555"/>
    <dbReference type="EnsemblBacteria" id="KWX20993">
        <property type="protein sequence ID" value="KWX20993"/>
        <property type="gene ID" value="AFM11_28035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3481"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031702">
        <property type="entry name" value="DUF5078"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16877">
        <property type="entry name" value="DUF5078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453269" evidence="1">
        <location>
            <begin position="30"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="153" mass="17342" checksum="1FC0F4D4388823D2" modified="2016-06-08" version="1">MPPTNLIRMGVAACAVAGTLAAAPGLAAADATDDYPIPNRILKTQCDAEQIMAAARDVEPIYYERYMIDYNNKPPADQQGARDRIHWFFSLDYAGRRQYSENTATNAFYEQMSWRWPNWAKLFFNNKGVAANTTDICMNYPRGDMSLWNWAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFE1</accession>
    <name>A0A132PFE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855355.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07155"/>
    <dbReference type="EnsemblBacteria" id="KWX21069">
        <property type="protein sequence ID" value="KWX21069"/>
        <property type="gene ID" value="AFM11_27225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3320"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="579" mass="62833" checksum="40C14E7E6BBF0166" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFG8</accession>
    <name>A0A132PFG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27260</name>
        <name evidence="4" type="ORF">AWC31_07195</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855373.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07195"/>
    <dbReference type="EnsemblBacteria" id="KWX21075">
        <property type="protein sequence ID" value="KWX21075"/>
        <property type="gene ID" value="AFM11_27260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09974">
        <property type="protein sequence ID" value="ORX09974"/>
        <property type="gene ID" value="AWC31_07195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3327"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021403">
        <property type="entry name" value="DUF3043"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11241">
        <property type="entry name" value="DUF3043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="235" mass="26155" checksum="A999870E1F2ED063" modified="2016-06-08" version="1">MKLLGRNIGRDKDDNGADKGTEGNAERTSVAEQAGPATNGSTTTTAPKGRPTPKRSEAAKRRGPVAPAPLTAAEARKRRKELRGPKLSKEERKAERLTRRADMADRREKMMAGEEAYLLPRDKGPVRRYVRDIVDSRRNVLGLFMPAALTMIFFMLALPAVQFQQILSYAMLGLVLVMVIDGFVLGRKVNRMVDAKFPDNVESGWKLGFYASSRASQLRRMRAPRPMVNRGDKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFH3</accession>
    <name>A0A132PFH3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040163.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20742">
        <property type="protein sequence ID" value="KWX20742"/>
        <property type="gene ID" value="AFM11_29050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3692"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="268" mass="28398" checksum="2362377CEDF1A0DE" modified="2016-06-08" version="1">MDTLVDYRVEGATARLTLNSLHNRNALSTELIAKLLRGLRAAVTDPQVRVVVLTHSGGTFCAGADLSESTASPPEELAVNRAREMTKLLRGILECPLPVIAAVDGHVRAGGMGLIGACDITVAGPRSTFALTEARIGVAPAIISLTLLPRMNARAASRYFLTGESFSSERAVEIGLATTAVTEIAAEVARFTDALVMGSPQGLAVSKALTTDPILRRFDRDAERLAAHSARLFVSSEASEGMVAFLEKRRPTWADTDRTRETGDVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFL7</accession>
    <name>A0A132PFL7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="7" type="ORF">AFM11_27520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855517.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07455"/>
    <dbReference type="EnsemblBacteria" id="KWX21121">
        <property type="protein sequence ID" value="KWX21121"/>
        <property type="gene ID" value="AFM11_27520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3378"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="209" mass="23766" checksum="0267A15A7FD95667" modified="2016-06-08" version="1">MSTLHKVKAYFGMAPMEDYDDEYYEDDDRGVARGGYTRRPREERFEEDAYGYEAREYDEGPAYRGGYPDEARFEPRMRGPREFDRPAPRLGAMRGSTRGALAMDPRRMAELFEAGSPLSKITTLRPKDYSEARTIGERFRDGTPVIMDLVSMDNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADVDVSAEERRRIAEAGFYSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG40</accession>
    <name>A0A132PG40_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_25540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854406.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21295">
        <property type="protein sequence ID" value="KWX21295"/>
        <property type="gene ID" value="AFM11_25540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2971"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="447" mass="48842" checksum="C93FAF38A5341996" modified="2016-06-08" version="1">MTTHTEPQHSRGYYLRMVIAGSIGNMIEWYDWFVYTTFAIYFAGQFFPKGDTTAQLLNTAAIFAVGFLARPLGGWLLGRLSDRSGRKAGLTITVTMMSFSALLIAVAPSHATAGYVGAAMLLIARILQGLSVGGEYATSAAYLTEVSKKGWRGLGASFQYISVTLGQIAGVLLLVILQFVLTDEQLNDWGWRVPFVIGAVAAVAVFYLRRGMHETDAYSTVEQQDSHNRRGTLAEVWKHRKAAFLVLTLTLGGSVAYYTYTTYLSSYLVNSVGLSKEDAARVNFIALVVFLFLLPLGGYISDKVGRRPVLIFFGLGTTLFTYPILQGMQNQPTWLWCLAYTLLGLLFVAGYSSVNAVVKAELFPTEVRTVGVAIPYNIAQAVFGGTASYVALALRDAGHEPWFFVYVSVCAAISLVTYLVMRETRDVELIAEPSKSSVAEARSSAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG89</accession>
    <name>A0A132PG89_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855186.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21012">
        <property type="protein sequence ID" value="KWX21012"/>
        <property type="gene ID" value="AFM11_26850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3241"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="206" mass="22471" checksum="8E7C7442A3037894" modified="2016-06-08" version="1">MSNRRQLIIDAARKLFATRPYDQVTTSEIAKQAGVAYGLIAHHFDNKRGLYLAVMNEIAVEIAAAQLAPPPSDAGPVDQLRHALRNHITYIDSYSDSFVALLRGALGADPEHQAAIERLRWLGAQRILSALGIVEPVTAALRTAMHGWVGYLDEMTIDRITNRDIDVDVLVELATAALVATLRTAAVVDPSIAYSPDVTDALESFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGD0</accession>
    <name>A0A132PGD0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_26065</name>
        <name evidence="11" type="ORF">AWC31_35835</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="7 8">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the rubredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854649.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35835"/>
    <dbReference type="EnsemblBacteria" id="KWX21380">
        <property type="protein sequence ID" value="KWX21380"/>
        <property type="gene ID" value="AFM11_26065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11996">
        <property type="protein sequence ID" value="ORX11996"/>
        <property type="gene ID" value="AWC31_35835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3077"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="9">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX11996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="60" mass="6852" checksum="A5369A1122267AFB" modified="2016-06-08" version="1">MNDYKLYVCVQCGFEYDEEKGWPEDGIAPGTRWDDIPDDWSCPDCGAAKSDFEMVEVARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGH1</accession>
    <name>A0A132PGH1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854038.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27105"/>
    <dbReference type="EnsemblBacteria" id="KWX21449">
        <property type="protein sequence ID" value="KWX21449"/>
        <property type="gene ID" value="AFM11_24850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2331"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="327" mass="33856" checksum="2634E33033850E12" modified="2016-06-08" version="1">MTIVLTHSDVAALIDRSVVYDVVEQAHADLSTGTATNPAPPVLPVGYGAAVLPMVAAATRQQASAVKMLSDMPSNRAAGLPTQRSTILLMSASTGECEAVLDGRLVTAIRTAAASAVATAHLARTSSTSLGLVGAGTLAVEHARAIARIRPIEKVFVWSRSRVTVDEFCHRIADLDLVVEPAETVSHVVSAADIVCTLTPSRDPIVKGGWFRPGLHVNAVGAPPRADHREIDGPGMAAARLIVDSRPTALAKSGDVLLAIGEGHLTEADVATELGDVIVDPALGRAGDDDITLFNSVGIGLQDLVTARSLVDTAVERGVGIRVDMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGK2</accession>
    <name>A0A132PGK2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_25505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854703.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24775"/>
    <dbReference type="EnsemblBacteria" id="KWX21394">
        <property type="protein sequence ID" value="KWX21394"/>
        <property type="gene ID" value="AFM11_25505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2964"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="9">
        <location>
            <begin position="14"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="10">
        <location>
            <begin position="304"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="8">
        <location>
            <begin position="631"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX21394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="707" mass="76597" checksum="231EDFDCDE17D092" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGY4</accession>
    <name>A0A132PGY4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853468.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21581">
        <property type="protein sequence ID" value="KWX21581"/>
        <property type="gene ID" value="AFM11_23885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2135"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="30"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="315" mass="35841" checksum="028DE88C820B3687" modified="2016-06-08" version="1">MTATSDLDLSVPADDEPVELVPLDSLTAEHTGRWTFLIFEGAAFMMQAMHPVIAEVTGRYSAAFQGDPGGRAIRSIDSVLRWTYGGTEAVAEGNRVRAMHRPMTMKSEKNGKQISALNPEAYQWVICTGYIVNVHGARLLIGREFTDTEKAELLRDNRRLARLLHVPMRDYPNTHQEMTDYFESMIDKLEATPQARKLIDDLVSGEVELPPSVPKLFYPLIKAVLRPALRFNYLSVVGLLDPRLRGKLGVEWSATEERQLNRVYKAIRVAYRVLPDRLTYFPLAYHARKHHECLEKMKERQKKSYAYRVPGAISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGY9</accession>
    <name>A0A132PGY9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1,4-beta-xylanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_24165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853623.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23950"/>
    <dbReference type="EnsemblBacteria" id="KWX21628">
        <property type="protein sequence ID" value="KWX21628"/>
        <property type="gene ID" value="AFM11_24165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2192"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453331" evidence="4">
        <location>
            <begin position="28"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="377" mass="42802" checksum="BDDEE0F30F697BE0" modified="2016-06-08" version="1">MARRTALKLPLAATAAAALIEAPSAGAEPGRWPAERANRWYRAQGWLVGSNYIAANAVNQLEMFQSATYDPQRIDGELRLARLMGFNTVRVFLHDQLWAQDRSGFQDRLAQFVAIVASRGIKPLLVLFDSCWDPLPKPGRQRRPRPGVHNSGWVQSPGVEHLDGRSHTGLRDYVVGVMSQFRNDDRILGWDLWNEPDNPARVYRAVELKNKQELVADLLPQVFRWARSVDPVQPLTSGVWHGEWRDPQRRSAIAKIQLDNSDVVTFHSYAKPADFEGRIAELAPLGRPVLCTEYLARGLGSTIEDILPIAKRHNVGAYSWGLVAGKTQTYLPWDSWDRPYPAPPEVWFHDLFHADGRPYRDHEIQTVRELTGRELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH31</accession>
    <name>A0A132PH31_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Signal peptidase I</fullName>
            <ecNumber evidence="3 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_25240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 6"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27560"/>
    <dbReference type="EnsemblBacteria" id="KWX21517">
        <property type="protein sequence ID" value="KWX21517"/>
        <property type="gene ID" value="AFM11_25240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2410"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="8">
        <location>
            <begin position="46"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="281" mass="30535" checksum="CFF14AF9E3AB1405" modified="2016-06-08" version="1">MDPVTGSTDSTDASSEDELDTDSDTSHSVAEEDKPQKRKHSALREGAILVTIALVLYYVMLTFVARPYLIPSESMEPTLHGCPGCVGDRIMVDKLTYRFSELEPGDVVVFKGPPSWNIGYKSIRSDNTAIRWVQNALSFVGFVPPDENDLVKRVIAVGGQTVECRAATGLTVNGKPLNEPYLNPTTMMADPNIYPCLGNEFGPVTVPKDRIWVMGDNRTHSADSRVHCTNLPADAQKGLLCTGDPMAGTVPVENVIGKARFIAWPPSRWGGISSVNPQTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH90</accession>
    <name>A0A132PH90_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853844.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23475"/>
    <dbReference type="EnsemblBacteria" id="KWX21700">
        <property type="protein sequence ID" value="KWX21700"/>
        <property type="gene ID" value="AFM11_24645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2290"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="68"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="420" mass="47745" checksum="410F3EE4A4BF8C71" modified="2016-06-08" version="1">MHTDDLILVSIDDHVVEPPDMFLRHVPAKYKDEAPIVVTDDKGVDQWMYQGRPQGVSGLNAVVSWPAEEWGRDPAGFAEMRPGVYDVHERVRDMNRNGILASMCFPTFTGFSARHLNMHREEATLVMVSAYNDWHIDEWAGSYPDRFIPIAILPTWNPEAMCREIRRVAAKGCRAVTMPELPHLEGLPSYHDDEYWGPVFRTLSEENVVMCLHIGTGFGAISMAPNAPIDNLIILATQVSAMCAQDLLWGPAMRNYPDLKFAFSEGGIGWIPFYLDRSDRHYTNQKWLRRDFGDKLPSDVFREHSLACYVTDKTSLKLRHEIGIDIIAWECDYPHSDCFWPDAPEQVLAELNAAGASDSDINKITWENSCRFFSWDPFKLTPREQATAGALRAKGADVDVSIRPRAEWARLYEQKQLAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHS0</accession>
    <name>A0A132PHS0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853012.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27855"/>
    <dbReference type="EnsemblBacteria" id="KWX21747">
        <property type="protein sequence ID" value="KWX21747"/>
        <property type="gene ID" value="AFM11_23090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1970"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="20"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="292" mass="32703" checksum="16ECE297FC014617" modified="2016-06-08" version="1">MDESQSVKNIWTSLGLPGIVDVHTHFMPKNVMDKVWQYFDSQGPLIGREWPITYRADEEQRVATLRSFGVRRFTSLVYPHKPDMAAWLNQWAFGFAQATPDCLATATFYPEAGAARYVAEAVAAGTQVFKAHIQVGRYDPNDPLLDDVWGSIEDAAVPVVIHCGSGPVPGDFTGPDRIARLLRRYPRLVLIVAHMGMPEYSEFLDLAEQFDQVRLDTTMAFTPFVESTMPFPAADTGRLHALGERILFGSDFPNIPYGYAEAVQTLIDLPGVDDKWLRNVLHDNAARLFDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHT8</accession>
    <name>A0A132PHT8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_23835</name>
        <name evidence="8" type="ORF">AWC31_24310</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853441.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24310"/>
    <dbReference type="EnsemblBacteria" id="KWX21572">
        <property type="protein sequence ID" value="KWX21572"/>
        <property type="gene ID" value="AFM11_23835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15674">
        <property type="protein sequence ID" value="ORX15674"/>
        <property type="gene ID" value="AWC31_24310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2125"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX15674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="331" mass="33891" checksum="ED6D37730B32D495" modified="2016-06-08" version="1">MTTGAPARATPPAASRFNVGTVLREPLVGPLVALVIAIVIFSSVSDSFLNPQNVSLILQQSVVVGILAVGQTLIILTSGIDLSIGAVAVFGTIVMAQSAGAYGPVVALGSTLLVCVVFGAINGGLVTMLRLPPFIVTLGTFTAILAGTRLLAGSETYRVEPGPLTFLGTSFRIGSFSTTYGVVAMLLVYAVMWYALSQTAWGKHIYAVGGNPGASNLLGVKSGRVLFSVYLTTGVIAAIAAWAALGRIPNADPNAYQNANLETITAVVIGGTSLFGGRGGVVGTLVGTLIVAVLRNGLTQAGVDSLYQNIATGILVIVAVAVDQFARRRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI59</accession>
    <name>A0A132PI59_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">polA</name>
        <name evidence="15" type="ORF">AFM11_22650</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08555"/>
    <dbReference type="EnsemblBacteria" id="KWX22048">
        <property type="protein sequence ID" value="KWX22048"/>
        <property type="gene ID" value="AFM11_22650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1880"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="13">
        <location>
            <begin position="14"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="12">
        <location>
            <begin position="317"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="14">
        <location>
            <begin position="660"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX22048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="904" mass="99313" checksum="BF3453D5975E6A09" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI70</accession>
    <name>A0A132PI70_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852288.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04135"/>
    <dbReference type="EnsemblBacteria" id="KWX22058">
        <property type="protein sequence ID" value="KWX22058"/>
        <property type="gene ID" value="AFM11_21320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1611"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="483" mass="52321" checksum="47A48F706F6CAE03" modified="2016-06-08" version="1">MSVISAFGDDALGDHDAVGLVEELRAGRVSAADLIEAAVTRVEAVNPTLNGLAFEAFDRAHARGAAPSPYGGFFDGVPTFVKDNVAVEGMPTMSGTDAWEPRPEPAHGDFARAYLATGLVPLGKTRLSEFGFSASCEHPRLGPVRNPWNPDYTAGASSSGSGAFVAAGVVPIAHANDGGGSIRIPAACNGLVGLKPSRGRLPQDANLRRMPLRIVSDGVVTRSVRDTAALYREMERVYRNPKLPPIGDVSRPGKQRLRIAVCTQSIAREASPEMRELTLKTAALLEELGHRITPIGNPVPASFKDDFLLYWAFLAYALVRGGTRTFGPSFDRGRLDNLTLGLERFAGRNLYRLPVAITRLARTRRITERLSNSYDAVLMPTLAEPTLPIGRLDPTADYEQIIERLIDWVAFTPLQNATGDPAISLPLAQTATGLPVGMMLSTTVGREARLLELAYELEEAQPWRRIQDSVVAPRRKRARKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIA4</accession>
    <name>A0A132PIA4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853921.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23710"/>
    <dbReference type="EnsemblBacteria" id="KWX21732">
        <property type="protein sequence ID" value="KWX21732"/>
        <property type="gene ID" value="AFM11_24415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2243"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453104" evidence="1">
        <location>
            <begin position="34"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="71"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="36915" checksum="D23ADB54658ED012" modified="2016-06-08" version="1">MSGFSRRQFGLMATVAAGAATLAACTTQSETPAAGTEAPPAPTHTLNPVKQITAGDLNVGYTEAGPADGAPVILLHGWPYDIHSYADVSAQLADQGFRVIVPFARGFGSTRFVSGATVRNGQQAALANDVIAFMDALNIPKAILGGYDWGGRTANVVAALWPQRVTGLVAVSGYIIVNLAANLQPLAPEAELGWWYQYYFATPRGELGYRQNTKEFNRLIWTRASPLWKFTDATYDLSAASFDNPDHVDIVVHNYRWRQSLAPGESRFDADEKRLAGKPPVTVPTITIGSDFDGAAKDGAGYRKLYTGPYEHRVLDGIGHNVPQEAPDQFSSAVVDVRAMGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIJ8</accession>
    <name>A0A132PIJ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852547.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22188">
        <property type="protein sequence ID" value="KWX22188"/>
        <property type="gene ID" value="AFM11_22105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1769"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="277" mass="29721" checksum="1CD0231D27337610" modified="2016-06-08" version="1">MIIESRATFGGVGTRMLSVTGTGTPVVLLHGYADSADTWRGVLARLEAMGRNAFAVDLPGFGRADRRCPGPLLPQFDDFADAILAQYGPAVLVGNSLGSATAVRAAARRPEQVAALVALDDPLNARHWLARIARSRDLSDRFWAGVGNIPVPNRAVRWLATQGVRRVLYGSPHAADPAVMGYWTDTFVSRVAVAALGRYAFQYARETVGGHRDIRVDCPTVVVHGARDRIIPVHSSRLLHQQIPGSELVVLPRSGHCPQLDDPDAVARIVVGTTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIK7</accession>
    <name>A0A132PIK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COG0840 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852521.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04845"/>
    <dbReference type="EnsemblBacteria" id="KWX22175">
        <property type="protein sequence ID" value="KWX22175"/>
        <property type="gene ID" value="AFM11_22040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1756"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018735">
        <property type="entry name" value="DUF2277"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10041">
        <property type="entry name" value="DUF2277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="88" mass="9562" checksum="A63FFE05FFEFC198" modified="2016-06-08" version="1">MCRNITELRGLEPAATAEEIEAAARQYVRKVSGITRPTGANIEAFEAAVAEVTATTTRLLDGLAPRRQPPKTVPPLRRPEVRARLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIR2</accession>
    <name>A0A132PIR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21930</name>
        <name evidence="3" type="ORF">AWC31_04735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04735"/>
    <dbReference type="EnsemblBacteria" id="KWX22226">
        <property type="protein sequence ID" value="KWX22226"/>
        <property type="gene ID" value="AFM11_21930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10694">
        <property type="protein sequence ID" value="ORX10694"/>
        <property type="gene ID" value="AWC31_04735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1734"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="108"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="220" mass="23372" checksum="806385E678FB2FAE" modified="2016-06-08" version="1">MTRQHISDTVGPLGWRLVLGAVYTEVLVPSMSDAVAAASHAVAAAGTDASGHLSVDIRADRAILRLRSAQAGTVTTRDLELAHAVSQALSGRGFEMAVGHEVIQSFEIAIDALDIEAVRPFWKAITGYEDEPGPSDLNAGLVDPFGRGPAIWFQQMDSPRAQRNRIHIDIDVPHDAARARIDAALAAGGTLVSDKAAPAFWVLADAEGNEACICTWQGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ84</accession>
    <name>A0A132PJ84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851851.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22409">
        <property type="protein sequence ID" value="KWX22409"/>
        <property type="gene ID" value="AFM11_19840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1302"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="160" mass="17148" checksum="D312EA1330CA2C12" modified="2016-06-08" version="1">MNDNRISATPATTHNRAVDGRIDCHPSLRCRAIARLRAGQLDAQLAVGAPTPPGSPIAVRATRLTSIAEREAIARTLRRAVHDAADSRMVFSSRIPLHRKNIEAAEPVIDAITLRLHSPLPVSARGMARLIRLLRDGTGPLYAYGRGDLTGRLGAALAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJA8</accession>
    <name>A0A132PJA8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852230.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06595"/>
    <dbReference type="EnsemblBacteria" id="KWX22344">
        <property type="protein sequence ID" value="KWX22344"/>
        <property type="gene ID" value="AFM11_21230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1592"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453120" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4185" evidence="2">
        <location>
            <begin position="106"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="436" mass="46033" checksum="F5CFA04F3D058977" modified="2016-06-08" version="1">MPAFRRLASVTLASTVAVALVHSLLTAPPAAADPCSVPPAGASARSATPRLPILHLPIGRKPASTAATSEAAKDTAVAPNTAARAAAAPAASAATTVDWITGPNSDSYSRFGISGADLGIIWDNGQSGANNQVLIAFGDTFGNCSVADQEWRKNTLFRSADRNLADGMSVPNPVPGNVYAGSPVDAARPNFSKQVIQSLGLAATEVTVIPTAGISVGTTQYVNFMSVSQWGAPGQWSTNFSAVAVSTNNGETWTVPVTSIRPSWFNTVPGVPFVWGDQNFQMGAYVRYGGFVYAYGTGAGRGGMPFLSRVAENAIADKSAYEYFTPFGWLRGFPFLAIQVVWAPGSEMSVAYIDYLKKFVMLYTNAASAVVMRTADKPEGPWSQAKTIVSSTAIPGGIYAPYIHPWSKGSDLYFTLSRWSDYSVMLMRTSLATTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJH8</accession>
    <name>A0A132PJH8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_21245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852235.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06610"/>
    <dbReference type="EnsemblBacteria" id="KWX22347">
        <property type="protein sequence ID" value="KWX22347"/>
        <property type="gene ID" value="AFM11_21245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1595"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="273"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="305"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="521" mass="55721" checksum="016D84FA34A4BF76" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJK2</accession>
    <name>A0A132PJK2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20025</name>
        <name evidence="4" type="ORF">AWC31_28490</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sbp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000016">
        <property type="protein sequence ID" value="ORX14039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036439818.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28490"/>
    <dbReference type="EnsemblBacteria" id="KWX22444">
        <property type="protein sequence ID" value="KWX22444"/>
        <property type="gene ID" value="AFM11_20025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14039">
        <property type="protein sequence ID" value="ORX14039"/>
        <property type="gene ID" value="AWC31_28490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1341"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009709">
        <property type="entry name" value="DUF1290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06947">
        <property type="entry name" value="DUF1290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018579">
        <property type="entry name" value="Sbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX14039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="110" mass="11643" checksum="569B4E0D9AA535E0" modified="2016-06-08" version="1">MIGIAALVVGIVLGLVFHPSVPEFVEPYLPIAVVAALDAVFGGLRAYLERIFDSKVFVVSFVFNVLVAALIVYVGDQLGVGTQLSTAIIVVLGIRIFGNAAALRRRLFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJR6</accession>
    <name>A0A132PJR6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_20365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851947.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22504">
        <property type="protein sequence ID" value="KWX22504"/>
        <property type="gene ID" value="AFM11_20365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1407"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="157"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="36957" checksum="9934D49DF8B2553E" modified="2016-06-08" version="1">MAYNIRNRSLLSLVHHTDRDLLYLIDLAQDLKRAKYSGLRRKSLDGKNIALIFEKSSTRTRCAFEVAAYDEGAHVTYIDPTSSQIGHKESMKDTARVLGRLYDAIEYRGFGQDIVEELAEFAGVPVFNGLTDEFHPTQMLADVLTMTEHCPKPIPDIAYAFVGDGRNNMANSLLLVGAKLGMDVRIGSPETLWPSEEHVKMCHDFAARSGARITITDDPVKAVNDVDFVHTDVWVSMGEPVQAWADRIAELLPFQVNSVLMAAAANPRVKFMHCLPAFHNSETKVGAKIAAQYPQLANGIEVTEDVFESPANIAFEQAENRMHTIKAVLVAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK33</accession>
    <name>A0A132PK33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_19405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851725.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15490"/>
    <dbReference type="EnsemblBacteria" id="KWX22663">
        <property type="protein sequence ID" value="KWX22663"/>
        <property type="gene ID" value="AFM11_19405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1214"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="312" mass="33408" checksum="FBE75C4434CF7512" modified="2016-06-08" version="1">MTTVIAPPAEPRPSAVTPRDIARAGATRRERDSRVKIWVGSICTLLVILPVAFARLLPLPSPDATHLGERRLPPLTDGHLFGTDQLGRDLLARVLYGGQVSLAVGILAVVVSGLIGLALGAAAGYWGGWVDTVVSRLLEAQLSLPLLMMLLLVVALFGPSIPVITFVIAIAQWPEIARLTRSLCLVEREKPYVAAARVLGLGGFAILLRHVIPNVVKQVSLVVLLLLAQAVLLESALSYLGAGPQRPFATWGRIISDGQDYVTTSWWLVTLPGLVIALLVIGVNLLGDGLRDRQGGFRFGLFKRLPLSKKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKA4</accession>
    <name>A0A132PKA4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851094.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05125"/>
    <dbReference type="EnsemblBacteria" id="KWX22768">
        <property type="protein sequence ID" value="KWX22768"/>
        <property type="gene ID" value="AFM11_17605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.876"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="390" mass="39930" checksum="A17ED464196BFAA9" modified="2016-06-08" version="1">MRVAVVAGPDPGHAFPALALCREFLAAGDTPTLLTGVEWLDTARAAGIDAIELDGLDPTELDDDADAGAKIHQRAARMAVLNVPRLRDLAPDLVVSDVITACGGLAAELLGLPWIELNPHPLYRPSKGLPPLGSGLAPGVGVRGRLRDAVMRALTARSWRAGLAQRSAARVQIGLPAADPGPLRRLIATLPALEVPRPDWPDEAVVVGPLHFEPTTAVLDVPPGSGPVIVVAPSTAVTGAQGMAELALESLRPGETVPAGARVVVSRLAGADTHVPPWAVVGLGRQDELLSHADLVICGGGHGMVSKTLLAGVPMVVVPGGGDQWEIANRVVRQGSAQLVRPLTADALTAAVGAVLGSPAYREAAARAGASAAEVADPVRVCHDALSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKG7</accession>
    <name>A0A132PKG7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_17755</name>
        <name evidence="6" type="ORF">AWC31_11875</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851144.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11875"/>
    <dbReference type="EnsemblBacteria" id="KWX22793">
        <property type="protein sequence ID" value="KWX22793"/>
        <property type="gene ID" value="AFM11_17755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18693">
        <property type="protein sequence ID" value="ORX18693"/>
        <property type="gene ID" value="AWC31_11875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.906"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="348"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX18693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="471" mass="51101" checksum="4D9852154ED360BE" modified="2016-06-08" version="1">MGSMQEYDLVVIGSGPGGQRAAIAAAKLGKTVAVIERGMMLGGVCVNTGTIPSKTLREAVVYLTGMNQRELYGASYRVKDKITPADLLARTQHVISKEIDVVRSQLMRNRVELYTGHGRFVDEHTIHVEDPSRAELITVRGRYVVIATGTKPARPAGVEFDEERVLDSDEILELKSLPASMVVVGAGVIGIEYASMFAALGTKVTVVEKRDNMLDFCDPEIVEALKFHLRDLAVTFRFGEEVTGVDVGSAGTVTTLASGKQIPAETVMYSAGRQGQTDHLDLTNAGLESDNRGRIFVDDNFQTKVDHIYAVGDVIGFPALAATSMEQGRLAAYHAFGEPTKGMMDLQPIGIYSIPEVSYVGATEVELTKNSIPYEVGVSRYRELARGQIAGDSYGMLKLLVSTEDLRLLGVHIFGSNATEMVHIGQAVMGCGGTVEYLVDAVFNYPTFSEAYKVAALDVMNKLRVLNQFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKI6</accession>
    <name>A0A132PKI6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretion protein Rhs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851185.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11950"/>
    <dbReference type="EnsemblBacteria" id="KWX22813">
        <property type="protein sequence ID" value="KWX22813"/>
        <property type="gene ID" value="AFM11_17880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.930"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="375"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="604" mass="64295" checksum="1BACC117F6E42523" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKI8</accession>
    <name>A0A132PKI8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851292.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12265"/>
    <dbReference type="EnsemblBacteria" id="KWX22860">
        <property type="protein sequence ID" value="KWX22860"/>
        <property type="gene ID" value="AFM11_18195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.996"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="140" mass="14936" checksum="612ABBDC5A4AAEDE" modified="2016-06-08" version="1">MILNDAAREFIGAGADATLVTLNPDGSPQVTLVWVALQSTPDGDELVTAHLAEHKKVRNVRRDPRVAVTIVDPGKVGQVMRPYLAINGTARVVEGGAKELLKNLAQTLANPDAKFPPDDAPDGWLTRIRIDKVGGVGPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKL4</accession>
    <name>A0A132PKL4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_18460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851333.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12415"/>
    <dbReference type="EnsemblBacteria" id="KWX22878">
        <property type="protein sequence ID" value="KWX22878"/>
        <property type="gene ID" value="AFM11_18460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1026"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="219"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="448" mass="49237" checksum="0B8BF7FEE9CE8041" modified="2016-06-08" version="1">MSKPIKQIHLAAHFPGVNNTTVWSDPASGSHIEFGSFVHFAQTAERGKFDFLFLAEGLRLREQNGLIYDLDVVGRPDTFTVLAALAAVTDRLGLTGTINSTFNEPYEVARQFASLDHLSDGRAAWNVVTSWDAFTGENFRRGGFLAEEQRYERAESFLAAAHTLFDSWHGDEIVADKDRGVFLSDPGAGKFSYRDAHFDIAGQFNVPRSPQGRPVIFQAGDSDHGRDFAARAADAIFSRHGTLEAGQQFYTDVKGRLAKYGRRHDQLLILPAATFVLGDTDAEAAEIAHEVRLAQVSPATAIKFLEQLWNRDLSDHNPDGPLPSVDPVVGENTIARGRASVRMHRDPIAVANEWRAKAEAEKLTTRELIVEVTGRQNFIGSPATVAATINTLVQEDASDGFILVPHVTPSGLDPFVDKVVPLLQERGVFRTDYEGTTLRDHLGLATPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL30</accession>
    <name>A0A132PL30_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850706.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01230"/>
    <dbReference type="EnsemblBacteria" id="KWX23003">
        <property type="protein sequence ID" value="KWX23003"/>
        <property type="gene ID" value="AFM11_16660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.682"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="97" mass="10670" checksum="5B67770070679443" modified="2016-06-08" version="1">MAVLSNDQVDAALPDLPGWERAAGALRRSVKFPTFLDGIDAVRRVAEFAEEKDHHPDIDIRWRTVTFALVTHSAGGITEKDVQMAEEINRILADGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLA5</accession>
    <name>A0A132PLA5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein LprB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17415</name>
        <name evidence="3" type="ORF">AWC31_02000</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850982.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02000"/>
    <dbReference type="EnsemblBacteria" id="KWX23135">
        <property type="protein sequence ID" value="KWX23135"/>
        <property type="gene ID" value="AFM11_17415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13322">
        <property type="protein sequence ID" value="ORX13322"/>
        <property type="gene ID" value="AWC31_02000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.837"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453429" evidence="1">
        <location>
            <begin position="33"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="197" mass="20993" checksum="A32C0CCE15757EDB" modified="2016-06-08" version="1">MHGVTVSTAAIARTRGARTLAVLATAMVPVFAACSTDEPASPEVPQTGAPAAADAKHGPFFPQCGGVTDQTVSELTQVQGLVNTATNSSGCQWLQGGSILGPHFSFTWFRGSPIGRERKTEELSRTSVEDINIEGHSGFIATGEDPLGRPGDINLCEIGIQFDDDFIEWSISFNQKPYPDPCEVAKELTRQSIVNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLD8</accession>
    <name>A0A132PLD8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_17120</name>
        <name evidence="9" type="ORF">AWC31_01690</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01690"/>
    <dbReference type="EnsemblBacteria" id="KWX23158">
        <property type="protein sequence ID" value="KWX23158"/>
        <property type="gene ID" value="AFM11_17120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13266">
        <property type="protein sequence ID" value="ORX13266"/>
        <property type="gene ID" value="AWC31_01690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.777"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="7">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="6">
        <location>
            <begin position="179"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX13266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="400" mass="41641" checksum="137A7834C7D868DD" modified="2016-06-08" version="1">MSESTVASSRERESEVRTPQVVVEDAEIFAAHEGGKLSVELKSPLDTQRALSIAYTPGVAQVSRAIATDHTLAAKYTWANRLVAVVSDGSAVLGLGDIGAAASLPVMEGKSALFKTFGGLDSIPIVLDTKDPDEIVETLVRLRPTFGAVNLEDISAPRCFEIERRVIEALDCPVMHDDQHGTAIVVLAALLGATKVLKRDMHELRVVVSGAGAAGVACTNILLAKGITDITVLDSQGIVSTGRDGLNPFKAELAGRTNPRGLTGGMAEALKDADVFLGVSAGLVPEELIATMAPNCIVFALSNPDPEIHPDAARKYASVVATGRSDFPNQINNVLAFPGVFRGALDAGARRITEKMKVAAAEAIFSVVGDDLAVDHIVPSALDPRVGPAVAAAVAAASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLI0</accession>
    <name>A0A132PLI0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850200.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16410"/>
    <dbReference type="EnsemblBacteria" id="KWX23200">
        <property type="protein sequence ID" value="KWX23200"/>
        <property type="gene ID" value="AFM11_15340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7183"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453114" evidence="1">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="243" mass="24928" checksum="9018D7971CC3E4FA" modified="2016-06-08" version="1">MPFAAKTKLRILVVAGLMAVGATACDANSGPVGSGAGDPRQVTVVGSGQVQGVPDTLTADVAMEFFAPDVSGALNQSSQRQQAVIDALVGSGVDRTDIATTQVSVQPQFPPDGTVTGAPTGYRASNAIQVKIRDTAKASDTLALIAGTGGDATRINSVAYSIEDDSDLVRDARSRAFDDAKSRAEQYAQLSGLSLGKVISISEESGATPPPPTPMPRAAMEAVPLEPGQQTVNFSVTVVWELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLQ4</accession>
    <name>A0A132PLQ4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_15795</name>
        <name evidence="12" type="ORF">AWC31_15970</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850358.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15970"/>
    <dbReference type="EnsemblBacteria" id="KWX23278">
        <property type="protein sequence ID" value="KWX23278"/>
        <property type="gene ID" value="AFM11_15795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17910">
        <property type="protein sequence ID" value="ORX17910"/>
        <property type="gene ID" value="AWC31_15970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7284"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="700"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX23278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX17910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="815" mass="85506" checksum="0157858545C36945" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM27</accession>
    <name>A0A132PM27_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849665.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09505"/>
    <dbReference type="EnsemblBacteria" id="KWX23398">
        <property type="protein sequence ID" value="KWX23398"/>
        <property type="gene ID" value="AFM11_13965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6896"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="35"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="199"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="361" mass="37091" checksum="034A8456D01DB073" modified="2016-06-08" version="1">MKIRGAVLEAIGLPRPYAESRPLRVGELDLAGPGPGELLVRIEAAGLCHSDLSVVDGNRVRPVPMLLGHEAAGIVEAGDLPEGQRVVMTFLPRCGHCPACATDGLTPCGPGSVANGAGTLMEGDIRLSRNGERVFHHLGVSGFATHAVVDRRSVVPVPADVPAVVASLLGCAVLTGGGAVLNVGKPQPGQTVAVVGLGGVGMAAALTALAHDDVRVIGVDQLSDKLARARELGVHETYTPEQAADLKAEVVIEAAGHPAALETAIALTGPGGRTITVGLPRPDARISVSPLGFVAEGRSLIGSYLGSAVPARDIPRFVELWRAGRLPVESLVSSSISLDDINAGMDELADGRAVRQIIDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM52</accession>
    <name>A0A132PM52_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cob(II)yrinic acid a,c-diamide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850475.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16730"/>
    <dbReference type="EnsemblBacteria" id="KWX23334">
        <property type="protein sequence ID" value="KWX23334"/>
        <property type="gene ID" value="AFM11_16125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7350"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="216" mass="24036" checksum="B6947F27F870C9F6" modified="2016-06-08" version="1">MLRHAFSPAERQAVYRAITERRDMRRFVPDSTVPADVLGRLLQAAHAAPSVGLMQPWRFIRITDAALRTKIHALVDEERAHTAEALGPRGEEFLALKVEGILDCAELFVVALGEGRERHVFGRRTLPQMDLASVSCAIQNMWLAARAEGLGMGWVSIFEPRPLAHLLDMPDGAEPVAILCLGPVPEFPDRPVLEIEHWTVGRPLPEFVSENGWPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM75</accession>
    <name>A0A132PM75_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_14065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849699.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09415"/>
    <dbReference type="EnsemblBacteria" id="KWX23415">
        <property type="protein sequence ID" value="KWX23415"/>
        <property type="gene ID" value="AFM11_14065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6917"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="335" mass="37552" checksum="BEDEB9357A76636A" modified="2016-06-08" version="1">MTQVQGRIWRAGEPDDEHFSFSAISDCLADDDTLLWADIYDPDHDTLRGLADELGLNVWAVEDAIAPNERTKASVYHTHTFFTVYAVETRVPNGDAVSALVKHRISAFVLPRGLITVRLPSVEASATEFDIGEVSRRFDELGGQRYGVGALLHGLLDVVVDGHFEAVQALDDAIESLEDELFADDGPKHGLQRRTFRLRKDLVELRRVVLPMREVVSTIQHRRLDAKMSPELDPLYADLYDHVLRASEWTESLRDMVTTVFETNLSLQDARLNTVMKKLTGWAAIIAVPTAITGFYGQNVTYPGINTVVGFIASSALIVVLVILLYVMFKRRDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM83</accession>
    <name>A0A132PM83_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850556.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16125"/>
    <dbReference type="EnsemblBacteria" id="KWX23374">
        <property type="protein sequence ID" value="KWX23374"/>
        <property type="gene ID" value="AFM11_15640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7250"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022307">
        <property type="entry name" value="Helicase_put_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03817">
        <property type="entry name" value="DECH_helic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="71"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="294"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="784" mass="83498" checksum="D504BC74626F1BE9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMI6</accession>
    <name>A0A132PMI6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849978.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18010"/>
    <dbReference type="EnsemblBacteria" id="KWX23548">
        <property type="protein sequence ID" value="KWX23548"/>
        <property type="gene ID" value="AFM11_14890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7089"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="221" mass="23062" checksum="AF0B0DA5829D9AB4" modified="2016-06-08" version="1">MPTALITGAGGGIGSAIAAALAPTHTLLLAGRPSAHLDELAERLGAPTWPLDLTDADSIEASSEVLAELDVLVHNAGVLYPGRVGESSAEEWRASFEVNVTGAVALTLALLPALRAARGHVVFINSGAGRTVSAGMASYSASKFALRAFADSLRADEPSLRVTSIFPGRTDSEMQRELVAYEGKEYDAGRFLRPETVAGLVANAVTTPPDGHVHEIVVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMS0</accession>
    <name>A0A132PMS0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23639">
        <property type="protein sequence ID" value="KWX23639"/>
        <property type="gene ID" value="AFM11_12595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6609"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="109" mass="11803" checksum="DE2F491EE88B7128" modified="2016-06-08" version="1">MARRAAERLPTQPSKPVTMFSPSRAVPGRREVVARPKRDQIGVSIPCGRNFGVVGLLPYLPLPTKLVTAVMPEIMPDADESADDLAVRVRDAMQTRLDALTAGRTPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMT8</accession>
    <name>A0A132PMT8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849018.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02940"/>
    <dbReference type="EnsemblBacteria" id="KWX23651">
        <property type="protein sequence ID" value="KWX23651"/>
        <property type="gene ID" value="AFM11_12660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6622"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="129"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="129"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="224" mass="25066" checksum="08D3E8BCF1B1D25D" modified="2016-06-08" version="1">MTRVLIADDDTVVRDVVRRYLERDGLDVSIAEDGTEALRLLGSERIDVAVLDVMMPGSDGLSLCRELRRHGDYSMPVILLTALGEEDDRIAGLEAGADDYLTKPFSPRELALRVRSVLRRTTGSTAPVPMELAVGELNVSTAARSVTVGGEAINLTNREFDLLVFFLTHTDTVFTREDLLKRVWRWDFGDLSTVTVHVKRLRAKLGDHHRVQTVWGRGYLWSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMV2</accession>
    <name>A0A132PMV2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaA</name>
        <name evidence="15" type="ORF">AFM11_14765</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849940.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18135"/>
    <dbReference type="EnsemblBacteria" id="KWX23527">
        <property type="protein sequence ID" value="KWX23527"/>
        <property type="gene ID" value="AFM11_14765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7063"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="13">
        <location>
            <begin position="192"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="14">
        <location>
            <begin position="404"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="200"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX23527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="499" mass="56006" checksum="AE462BE1A26007C5" modified="2016-06-08" version="1">MTADPDPPFVAVWNSVVAELNGDHEGGRQGDSSLPALTPQQRAWLKLVKPLVIAEGFALLSVPTPFVQNEIERHLREPIVTALSRKLGQRVELGVRIATPPDEPDDPGPDSAHDPAPLSVDTDEIDDDREAKVNAEESWPTYFSSPQQDPAAADGNAVNLNRRYTFDTFVIGASNRFAHAATLAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKASFKRSYRDIDILLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPELETRIAILRKKAQMDRLDVPDDVLELIASSIERNIRELEGALIRVTAFASLNKTRIDKSLAEVVLRDLIADATTMQISTAAIMAATAEYFETTVEELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAEKKIRGEMAERREVFDHVKELTTRIRQRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNL3</accession>
    <name>A0A132PNL3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cation:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13465</name>
        <name evidence="3" type="ORF">AWC31_03750</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849394.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03750"/>
    <dbReference type="EnsemblBacteria" id="KWX23777">
        <property type="protein sequence ID" value="KWX23777"/>
        <property type="gene ID" value="AFM11_13465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11238">
        <property type="protein sequence ID" value="ORX11238"/>
        <property type="gene ID" value="AWC31_03750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6787"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="112" mass="12050" checksum="90CCDD02902A1CFD" modified="2016-06-08" version="1">MNVLDIITAILILSGSTLALTAAIGIVRFPDTLSRMHAATKPQVLGLLLVLAGAAIRLRGHADVGMVILTGLFTLITAPVIANRVGQLAYREQNIRDDLLTRDEMAEFEGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNQ4</accession>
    <name>A0A132PNQ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848127.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30650"/>
    <dbReference type="EnsemblBacteria" id="KWX23945">
        <property type="protein sequence ID" value="KWX23945"/>
        <property type="gene ID" value="AFM11_11245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6326"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017881">
        <property type="entry name" value="NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40562">
        <property type="entry name" value="PTHR40562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske_2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="123" mass="12993" checksum="42DAE32F257B9C56" modified="2016-06-08" version="1">MTLLDDREDSHAQTLSEWTTACSYDYLMPCRGVAVLLPDGSQAALFRLDDGSLHAVGNIDPFSGAAVMSRGIVGDRGGRATVQSPIKKQAFAFDDGSCLDDAAVSIPVYRTRVTSAGIVQIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNT4</accession>
    <name>A0A132PNT4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848224.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23975">
        <property type="protein sequence ID" value="KWX23975"/>
        <property type="gene ID" value="AFM11_11425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="114" mass="12653" checksum="892BB332F4CAC2FF" modified="2016-06-08" version="1">MVSPFFEFDWCARLFRSNEFPGAGEQATLALVEQFAAVEGQDADKFDEPSIEPLCVHAESRQDIFVEWAAVRGPLDHIANDVPIEFIDALAGHQRFGLASTYGAVLKKTFFTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP20</accession>
    <name>A0A132PP20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848553.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09965"/>
    <dbReference type="EnsemblBacteria" id="KWX24080">
        <property type="protein sequence ID" value="KWX24080"/>
        <property type="gene ID" value="AFM11_12010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6481"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="32"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="37438" checksum="FF1150104FE7E449" modified="2016-06-08" version="1">MSVISDDRVVAQLALAEYDISPDASLRLLNLSENATYLVEDGGAQSILRVHRQNYHRPHEIESELDWLAALRADSDVTVPTVLPARDGRRLVSVKSDDPAGTTRHVVHFDMVGGVEPDESSLTVQDFHTLGCITAALHEHSQRWTRPAGFGRFSWDWEHSLGDQPRWGRWQDAEGVGPTETRLLERAQTLLRQRLEKYGTTPDRYGLIHADLRLANLLVAPGDGESQITVIDFDDCGFGWYFYDFGTAVSFIEDDPALPDWQAAWVEGYRTRRELPAVDEEMLASFVLLRRLLLLAWMGSHSHSRESATKAISYAAGSCELAERYLSSDGLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP30</accession>
    <name>A0A132PP30_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11760</name>
        <name evidence="4" type="ORF">AWC31_30270</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848413.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30270"/>
    <dbReference type="EnsemblBacteria" id="KWX24034">
        <property type="protein sequence ID" value="KWX24034"/>
        <property type="gene ID" value="AFM11_11760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12291">
        <property type="protein sequence ID" value="ORX12291"/>
        <property type="gene ID" value="AWC31_30270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6430"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021424">
        <property type="entry name" value="PorA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11271">
        <property type="entry name" value="PorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX12291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="398" mass="43256" checksum="BE63DB7C6AB7517B" modified="2016-06-08" version="1">MNRAVALRIAACGLMGLGAALLIAALLLTTYTKSKIAKIPLDIDTTLVSDGTATAFDPASLTAEKFSIDRNVPVALQQQISVEAPSNAEVVTLQVGSSLRRTDRQQDNGLLLAMVDTVTVNRNSALAVSSENNPGGAVQKPRAIEDEKPPTNIALPHEGLTYRFPFDTEKKTYPFFDPIAQKPFDANYDGEEDVNGLTAYRFIQNVGYDAEGKLVEPVKYSSLYEDDADSSVTARAEMWGVPGEPDESITMDRYYAAQRTFWVDPVSGTIVKAEEHGYQYYAREALKPEVTYVDYKVTSTEETVESQVSAAQDERDRVALWTRILPITFTALGLIALVGGAVVGSFAVRAESTLIDPGLDTADHGFFDTQGIQVPGAEAKTEKLPAQRPSDLPPDRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP63</accession>
    <name>A0A132PP63_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13755</name>
        <name evidence="4" type="ORF">AWC31_04000</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849493.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04000"/>
    <dbReference type="EnsemblBacteria" id="KWX23822">
        <property type="protein sequence ID" value="KWX23822"/>
        <property type="gene ID" value="AFM11_13755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11277">
        <property type="protein sequence ID" value="ORX11277"/>
        <property type="gene ID" value="AWC31_04000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6847"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="439" mass="47283" checksum="15E4A3294D528317" modified="2016-06-08" version="1">MTVELAHPSTEPLASRSPTTPAHPRWWFLWTTPGRILTIGVVLCALVVASAFATSTTINDRQQALTTVLDHTEPLSFAAGRLYTTLSVADAAAATAFIAGAEPRDVRQRYEQAITDASVAVTRASSGLTDEELVQLLGRINARLAVYTGLVETARTNNRAGNPVGSSYLSEASAMMQTQILPDAQRLYEQTSARVDAETTASAQIPTPVMLVVLATLLFGAFANRWLARRTRRRVNIGFVAGGLAVLIMLIWVSTALVISTSDSRSAKETAAESLKTVTNLAITAQQARADETLALIRRGDENVRKQSYYQRIDMMQQQLSDYLARDTGIDTSDLVGAEQLLTKWRAADDRINAYIAVGNYQAATQVALGTGEDDSTPAFDKLDAALSKGIEQSRSQLRNDIANARRVLSGATVGAALLSVAAAIAVALGLWPRLSEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPD8</accession>
    <name>A0A132PPD8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_13815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23902">
        <property type="protein sequence ID" value="KWX23902"/>
        <property type="gene ID" value="AFM11_13815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6859"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="389" mass="39496" checksum="F8D89FC3513542E5" modified="2016-06-08" version="1">MGLLLVHAVGVQIVSYALRPAISYAILDLGHGPAWLGVATAAFAVPPLLLAVPAGRFVDRVGERASMVLGALAFVGAAAVLVSVGATLAGLLAATVLLGLGVLFSVVAEQAWVMRDAAAGRLDFVFGVYTFATSGGQMLGPALLLLPSAEVHSPAFTTIAWATLGIALVGLVLSLVIPSTARPDATTDKPTAMWPVASRLLRTKGVVPALVTSSLVLSSLDIVLAYLPLLARERGLSPAWLTALLVTRGVATMASRLTLGRMTNAFGRRRVLVVAGAVAAVSLIALVLPVPAVVLVICMASYGLAAGTVQPLTMSWMTLVTPRPDRGVAASLRLVGNRAGQTGIPLAVAGISALGGASVVFAATGATLLVSARLSRWAPDGDDAGGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPQ3</accession>
    <name>A0A132PPQ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10005</name>
        <name evidence="3" type="ORF">AWC31_05220</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847406.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05220"/>
    <dbReference type="EnsemblBacteria" id="KWX24311">
        <property type="protein sequence ID" value="KWX24311"/>
        <property type="gene ID" value="AFM11_10005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09637">
        <property type="protein sequence ID" value="ORX09637"/>
        <property type="gene ID" value="AWC31_05220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6037"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="12"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="205" mass="23171" checksum="5CFE533F2549934E" modified="2016-06-08" version="1">MANKDGKNTAGFWFDPLCPWCWITSRWILEVEKVRDIEVQFHVMSLAVLNEGRDLPEEYQEAMKKAWGPVRVAIAAEQLKGPEILSPLYTAMGFRIHNLENKDFDEVIAQSLEEVGLPAELAEAATTDKYDEALRKSHHAGMDAVGEDVGTPTIHVNGVAFFGPVLSRIPRGEEAGKLWDASVTFASYPHFWELKRTRNERPEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPX5</accession>
    <name>A0A132PPX5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_09695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847243.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05530"/>
    <dbReference type="EnsemblBacteria" id="KWX24257">
        <property type="protein sequence ID" value="KWX24257"/>
        <property type="gene ID" value="AFM11_09695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5977"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="327" mass="34304" checksum="31FB4F1B8B0A7E18" modified="2016-06-08" version="1">MRDRPTLHDVAQRAGVSRALVSIVMRDAPGASEATRERVRRAADEIGYRPDPRARMLRSARTNLLGVVFTASQEFHAGLVDGVYRAAELRGYDVLLSCVTPHHGERQAVRTLLDNRVEALVLIGPELPTRELIELDSRLPVVTVARKLRGVDAVRSDDAVGAGLAVDHLAGLGHRAITYLDGGRAAGAAERRKGLRKAADAAGVAATIAAGGITEREGAAAATALLATESALPTAVFAFNDRCALGFVDVAIRAGVRVPSDVSVVGFDDSPLAGLAHVDLTTVGQDSAQLAELAVGRAVERIDGTGSRVDLVCEPKLVVRGSTAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPX9</accession>
    <name>A0A132PPX9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_10520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847661.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24390">
        <property type="protein sequence ID" value="KWX24390"/>
        <property type="gene ID" value="AFM11_10520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6144"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="120"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="579" mass="61275" checksum="172A8393A069F355" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ23</accession>
    <name>A0A132PQ23_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847811.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19320"/>
    <dbReference type="EnsemblBacteria" id="KWX24438">
        <property type="protein sequence ID" value="KWX24438"/>
        <property type="gene ID" value="AFM11_10805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6200"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="125"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="268" mass="28645" checksum="6A1C0E9AEDC473CA" modified="2016-06-08" version="1">MTMDRESLELLEDGLRKTMLTTSGPELDAALVELGWAEMLSDMPDVAVPLVFRLLGETGSHASVLVDVVLNATGNEIGGTLELPLPYAGNTWVVWDRTAAQSTDPTLGGLPLRREDEGYPIRVAEARLAVGWWLVGSARAMLALARQHALDRVQFGRPIASFQAVRHRLAETLVAIEGAEATLTLPGADNPDLTALLAKAAAGKAALTAAKHCQQVLAGIGFTEEHDLHRHVKRALVLDGLLGSSRELTRRAGAGLRARGSVPRLAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ98</accession>
    <name>A0A132PQ98_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847981.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19270"/>
    <dbReference type="EnsemblBacteria" id="KWX24506">
        <property type="protein sequence ID" value="KWX24506"/>
        <property type="gene ID" value="AFM11_10755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6190"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="420" mass="44487" checksum="D1969FBD1B2C7635" modified="2016-06-08" version="1">MPHDTPGSAGPLAGITIVALEQAVSAPMCTRVLADFGARVIKVENPKGGDFARDYDEVVNGLAAHFVWANRGKESITLDLKSTGGIDVLHRLLDRADALVSNLAPGAMARMGLSPAELSQRHPQVIPVEIDGYGTGGPLSHKRAYDLLVQAESGACAITGYPDMPAKPGPPVADISTGLYAALSIMALLIGRARQPSDAPAPAVAVSLFDTMTDIMGYPLTYTQHSGIDQQPLGMSSPAVSPYGAFPTRDGQTVVLGTTNDREWQRLAREIIDRPDLADDPRFATNSDRCASRDVLNDAIGTWCAQHDLAEIQQIADEAGIGNSRYNRPSEVIAHQHLKDRDRWRTVATPNGDISALLPPPVISGHELPMGAVPGLGEHTDAILGDMGLSAEDIAALREQGAIGPAYPTSQIPRAEQSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQH9</accession>
    <name>A0A132PQH9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="3 9">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pdhA</name>
        <name evidence="11" type="ORF">AFM11_07500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 9"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845975.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22000"/>
    <dbReference type="EnsemblBacteria" id="KWX24524">
        <property type="protein sequence ID" value="KWX24524"/>
        <property type="gene ID" value="AFM11_07500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5348"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="E1_dh" evidence="10">
        <location>
            <begin position="23"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX24524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="37343" checksum="737D306163C95AEC" modified="2016-06-08" version="1">MTDTIDRPTHVGEDLETLCGYYRQMVLIRRFEERAAQGYTQAKVGGYCHLNLGEEATVVGLMAALRPTDYLFTNYREHGYAIAKGIDPKRVMAELFGRTTGTSKGWGGSMHMYDTETRLLGGYGIVGGQLPLAVGAALAIDYRGGDDVVMCQMGDGTTNIGAFHESLNIAALWRLPVVFVVINNNLGMGTTVEKSSAEPELYKRAAAYRMTGERVDGTDVLAVRDAARRLVEAARSEGKPALLEAVSHRLRGHSVVDPAKYRTESDVAAAHEADPLTLFKHTLLRAGAFDEDGAAALEKSAQEEADAAVAFADASPHPDPSTLFDYTYATPVPGESRRLPADPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQN1</accession>
    <name>A0A132PQN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846313.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24640">
        <property type="protein sequence ID" value="KWX24640"/>
        <property type="gene ID" value="AFM11_08160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5483"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="121" mass="13536" checksum="0ABED80D8CAAA298" modified="2016-06-08" version="1">MQATEDILRGVLDVWKAGIDAHEPQRVADVFTADAIFQGLRPYSVGQQGVFEYYDSQPAGMTVDYRIRETRDLADGVVLGYLVADFSFRDRDPIHLNLGVVVTRNDAGWHIAHYQVSPVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQW2</accession>
    <name>A0A132PQW2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_08670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846561.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13700"/>
    <dbReference type="EnsemblBacteria" id="KWX24728">
        <property type="protein sequence ID" value="KWX24728"/>
        <property type="gene ID" value="AFM11_08670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5584"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="341" mass="36998" checksum="BC0C0CA51D13B838" modified="2016-06-08" version="1">MPAPQPQPVLAPLTPAAVFMVATIDEGQEAAVHDALSDISGLVRAIGFRDPAKRLSAIVSIGSDAWDRLFSGPRPAELHPFVELQGPRHHAPATPGDLLFHLRAESMDVCFELATKLVEAMSGAITIVDEVHGFKFFDNRDLMGFVDGTENPDGPVAINATQIADEDPDFAGSCYVHVQKYLHDMGSWNSLSTEEQERVIGRTKLDDIELDDAVKPANSHVALNVIEDEDGNELKIVRHNMPFGEIGKGEFGTYYIGYSRTPAVTERMLDNMFIGDPPGNTDRILDFSTAVTGGLFFTPTIDFLDDPPPLPSEDNQRPQVAVATPVSYDGSLGIGSLKGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR87</accession>
    <name>A0A132PR87_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846935.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24630"/>
    <dbReference type="EnsemblBacteria" id="KWX24840">
        <property type="protein sequence ID" value="KWX24840"/>
        <property type="gene ID" value="AFM11_08030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5456"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021391">
        <property type="entry name" value="DUF3027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11228">
        <property type="entry name" value="DUF3027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="267" mass="28085" checksum="0AE311B347765216" modified="2016-06-08" version="1">MESVTESAEQAPEAGLSSGLATSVEPEPRLESLLLGAVEQARAALSEFSGEDTVGEYLGATFEDPSSATHRFLANLPGYRGWQWAVVVAAYPGADHATISELVLVPGPTALLAPKWVPWNERIRPGDLSPGDLLAPPPADPRLVPGYLATGDPLIDDTAVELGFGRRQVLSDWGRAGAAQRWHDGDYGPASAMARSTRRVCRDCGFYLPLGGALGPMFGVCANELAADGHVVDAEYGCGAHSDTPQPPGTGSPMYEPYDDGVLDLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR91</accession>
    <name>A0A132PR91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24843">
        <property type="protein sequence ID" value="KWX24843"/>
        <property type="gene ID" value="AFM11_08145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5480"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010645">
        <property type="entry name" value="MFS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06779">
        <property type="entry name" value="MFS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="MFS_4" evidence="2">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="393" mass="40370" checksum="35CB7AF4BEA1FFDF" modified="2016-06-08" version="1">MGIGRFVYTPILPLMTAQAGISPHTAANLATVNYVGYLAGALMGTVWPRLARSMTACRVCLIALIASLAAMPLSTNPIEWTALRAVAGLTSALVFVIAVNTMLEHLHDHPARLAGWGFGGIGAGIALSAVLVLAIDDWKAAWWASAAVSAVLAIGAWSMQHAPETATVVDDAEQRPPHGAFSMLLASYTLEGIGYIIAGTFLVAAVAQGTPDWLGGGTWLVVGVATVPSAALWATLSSRWSHPGLLVAALCLQAVGIAVAGLVGGITAALVGAVLFGGTFVGVSTLALAAGRLLRYPRAVALLTAGYSVGQIVGPLVVAPLLHHGFRPALVLGAVVVLAAALIAGLMRIVGGQPDRRVRQPEINGAAGEFIDDSVDSGVLFATPPHQRPRPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRM3</accession>
    <name>A0A132PRM3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ORF">AFM11_05910</name>
        <name evidence="5" type="ORF">AWC31_11770</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000002">
        <property type="protein sequence ID" value="ORX19242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845142.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11770"/>
    <dbReference type="EnsemblBacteria" id="KWX24970">
        <property type="protein sequence ID" value="KWX24970"/>
        <property type="gene ID" value="AFM11_05910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19242">
        <property type="protein sequence ID" value="ORX19242"/>
        <property type="gene ID" value="AWC31_11770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4373"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX19242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="375" mass="39907" checksum="9E03CAD864904987" modified="2016-06-08" version="1">MTTRNQAVLVLEDGRVFSGTAFGAIGQTLGEAVFSTGMSGYQETLTDPSYHGQIVVATAPQIGNTGWNREDGESRGDKIWVAGYAVRDPSPRASNWRADGTLEDELVAQGIVGVAGIDTRAVVRHLRTRGSMKAGVFSGDALAEPDELLERVRSQPSMLGANLAGEVSTEATYVVEPEGTQRFTVAAVDLGIKTNTPRNFARRGIRSHVLPSSVTFEQIADLKPDGVFLSNGPGDPATADHIVEVTREVLGAGIPLFGICFGNQILGRALGRSTYKMVFGHRGINIPVIDHITGRVAITAQNHGFALEGEAGETFDTPFGAAEVSHTCANDGVVEGIRLANGRAFSVQYHPEAAAGPHDANYLFDQFVDLMAEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRR4</accession>
    <name>A0A132PRR4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Transaldolase</fullName>
            <ecNumber evidence="6 8">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tal</name>
        <name evidence="9" type="ORF">AFM11_06250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the transaldolase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="6 8"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845247.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29425"/>
    <dbReference type="EnsemblBacteria" id="KWX25029">
        <property type="protein sequence ID" value="KWX25029"/>
        <property type="gene ID" value="AFM11_06250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4443"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00955">
        <property type="entry name" value="Transaldolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00493">
        <property type="entry name" value="Transaldolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004732">
        <property type="entry name" value="Transaldolase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036915">
        <property type="entry name" value="Trnald_Bac_Plnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00876">
        <property type="entry name" value="tal_mycobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="371" mass="39745" checksum="4C148A7C760A145C" modified="2016-06-08" version="1">MTQNPNLAALSAAGVSVWLDDLSRDRLQTGNLQNLIDTRSVVGVTTNPSIFQAALSKGTAYDAQVKELAERGADVDATIRTVTTDDVRNACDVLAKQYEASGGVDGRVSIEVDPRLAHDTDKTILQAIELWKIVDRPNLLIKIPATLAGLPAITAVIAEGISVNVTLIFSVERHRAVMDAYLAGLEKAKEAGHDLSKIHSVASFFVSRVDTEIDARLDKIGSEDALALRGQAGVANARLAYAAYEEVFGGDRYAALKADGARVQRPLWASTGVKNPEYSDTLYVTELVAPNTVNTMPEKTLEAVADHAEITGNTVSGTAAAAQETFDKLAAIGIDLPDVFKVLEDEGVEKFEKSWQELLDATQGQLDAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRT8</accession>
    <name>A0A132PRT8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_08830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846636.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13540"/>
    <dbReference type="EnsemblBacteria" id="KWX24752">
        <property type="protein sequence ID" value="KWX24752"/>
        <property type="gene ID" value="AFM11_08830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5614"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="21602" checksum="66BA5CEB5B2F2136" modified="2016-06-08" version="1">MSSDAVAAVTGPVSETPRNRRQEETFRKVLTAGIEMLRESSYADLTVRAVAARAKVAPATAYTYFSSKNHLIAEVYLDLVRQVPYFTDVNDSMTTRVDKAVRALTLVVADEPEVAAACTTALLGGGTDPAVRAVRDRIGAEIHKRIRSAVGPDADPRIVSALEMTFFGALVNAGSGAFTYHQIADRLTYVVGLLLGDENTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS31</accession>
    <name>A0A132PS31_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_06785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845453.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28865"/>
    <dbReference type="EnsemblBacteria" id="KWX25120">
        <property type="protein sequence ID" value="KWX25120"/>
        <property type="gene ID" value="AFM11_06785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4556"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="169" mass="17900" checksum="0A81F808599796FF" modified="2016-06-08" version="1">MVHSVELVFDADTEAAVRHIWDGLRDAGIPSQAPSGRPHATLTVAQHIDAAADAVLRPLTDRFPIPCQLGATLIFGRSAGVLARLLVPSPALLDVQAEVYRACLPLVSPAALPHTEPGQWTPHVTLARRVAPAKLAAALRIAGRPAEIVGTVVGLRHWDGDKKAEHPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS54</accession>
    <name>A0A132PS54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SalK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_07125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845632.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17590"/>
    <dbReference type="EnsemblBacteria" id="KWX25181">
        <property type="protein sequence ID" value="KWX25181"/>
        <property type="gene ID" value="AFM11_07125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4623"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="295" mass="32158" checksum="F81928B9277F8F63" modified="2016-06-08" version="1">MGRTPSLARRFFDRLEPVHAVTYFAPESRSALEALGYRGFWMGYFAARSAPFGIVPPEVVTAVFYNFTAERVAKALPAAWDIAPPATLLAVRLESAVAALRRSGVTDGDATRTAAELAVKAARSAPLDGRPLYAANLALDWPDDPIARLWQAVTLLREQRGDAHVAVLAAEGISGRECNVLHAAAGRVPRDMIMRSRDYDDEQWQHYSESLRQRGWLDGDGELTESGRAAKQAVEDRTDALALRALDTLTDDEVERLFGALTPITRQVVAAGDVPVVTPMGLSRHDLDDDSAHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSH6</accession>
    <name>A0A132PSH6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25308">
        <property type="protein sequence ID" value="KWX25308"/>
        <property type="gene ID" value="AFM11_03195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2513"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453547" evidence="1">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="103" mass="10228" checksum="4661A8DBFF0D11B9" modified="2016-06-08" version="1">MVNVAKIVKTLVGASAALAAFGLVGAPTAAADPQCTDVGGATRCSSPGNVQINATPTQRGPYLPYGCDPAYAALCYDDLPGIAIDIGGGGDHHPGGGGRHPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTE1</accession>
    <name>A0A132PTE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_05085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844734.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20145"/>
    <dbReference type="EnsemblBacteria" id="KWX25608">
        <property type="protein sequence ID" value="KWX25608"/>
        <property type="gene ID" value="AFM11_05085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2898"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="513" mass="58380" checksum="9EA7FEFF8BE9A617" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTJ0</accession>
    <name>A0A132PTJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844812.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20025"/>
    <dbReference type="EnsemblBacteria" id="KWX25646">
        <property type="protein sequence ID" value="KWX25646"/>
        <property type="gene ID" value="AFM11_05315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2949"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="218" mass="23608" checksum="F84A7B9867B7D12A" modified="2016-06-08" version="1">MSGRHSLKAFDKAGAKPIEDPVEETAEDAAEETAEDASEAEGVDTEPEPPAEPARRTAWSRIVAFAVLPALALVLAAGSAFLKWQIVSERESATARTESVEAAKDITVQMLSYEPDTVEQHLNSVLDRLTGEFLGTYTTMIRTTIIPGATAQRVTAHAEVPAIGSVTASPDRAEVMLYLNQFVTVGDQPPQKTPSTVRATMVREDGRWLMSQFEPVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTN1</accession>
    <name>A0A132PTN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844765.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25624">
        <property type="protein sequence ID" value="KWX25624"/>
        <property type="gene ID" value="AFM11_05185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2919"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="81" mass="8662" checksum="161E45C1993E1E05" modified="2016-06-08" version="1">MTAASYVPADPRTRSAKGWRARLGAMASRGEVDGPRVAEAKAALSWWKARGLLVDDLGVDPVRAESLLAVIFPEVAETVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTS8</accession>
    <name>A0A132PTS8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">AFM11_04125</name>
        <name evidence="10" type="ORF">AWC31_21030</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844380.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21030"/>
    <dbReference type="EnsemblBacteria" id="KWX25452">
        <property type="protein sequence ID" value="KWX25452"/>
        <property type="gene ID" value="AFM11_04125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16522">
        <property type="protein sequence ID" value="ORX16522"/>
        <property type="gene ID" value="AWC31_21030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2703"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX16522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="219" mass="22845" checksum="4BE5AF003765B6FA" modified="2016-06-08" version="1">MAKAAKTNATNKLTATVRTRTGKGASRQARRAGLVPTVLYGHGTDPQHLELNAHEFAAVLRKAGTNAVLTLDIDGKEELALTKALDIHPIRRNIQHADLLVVKRGEKVTVEVTVVVEGEAQPGTLVTQDANTIEIEAEALSIPEQLTVSVEGVEAGTQFTAGQIALPAGVNLISDPELLVINVVEAPSAEDLEAEGAGETAEAPAAEEPAAEAAEESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTT9</accession>
    <name>A0A132PTT9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cutinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_00095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842057.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33200"/>
    <dbReference type="EnsemblBacteria" id="KWX25740">
        <property type="protein sequence ID" value="KWX25740"/>
        <property type="gene ID" value="AFM11_00095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.19"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453591" evidence="2">
        <location>
            <begin position="30"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="272" mass="27513" checksum="258F8F8001EB17B6" modified="2016-06-08" version="1">MFRRLSALVSAAAIAGAALIGLTAATASANPTCPDVHWIGVAGSGERTDPAVNGGMGRPVYQSLQDFSRLVQQDGRTMTAEAVVYPATEVPADGDLLGWGGFMGSVDAGVAALGSQYAAFTQRCPATSVVLAGYSQGAMVVHRNLHALATSPNLAAALLIADGDRLPTDPTINLGSVTGVPGAGKGVAQDWPILAHAPAALPVSVGSRTISVCNLGDAVCDYDPEAEEVTAAAIAVHTSYATAGGGQLPWTWTLYQLASRSAMGSQMVPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUQ1</accession>
    <name>A0A132PUQ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_02050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843045.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34830"/>
    <dbReference type="EnsemblBacteria" id="KWX26050">
        <property type="protein sequence ID" value="KWX26050"/>
        <property type="gene ID" value="AFM11_02050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.420"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="33"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="493" mass="51796" checksum="96AFC7FF1B0490F1" modified="2016-06-08" version="1">MTTLDDWTRRAGEITPRTEVFIDGKYRAALSGATFDSVNPATGELIAPVASGDSADVDAAVAAARAAFESGAWSRTSASHRKRVLRQLSELILANGEELALLDSIDMGKLVAEAHTVDVPSAAELFAFYGEALDKQSGEIAPTEPGNLALVTREPLGVVGAVTPWNFPLDLAVWKVAPALAAGNSVVLKPAEQAPLSSIRLAELAVEAGLPEGVLNVVPGLGPTAGEALGRHPDVDVIAFTGSTETGKRFLRYAADSNAKQVWLECGGKSPNLVFADADLDAAVDKAIFGAFYNQGAVCSSNSRLLLHDSIADEFLAELVKRTAEVRPGNPLDPASTLGALVDEHHTRRVIGFIDRARADGEILTGGTRETVDGRGCFVSPTIVANLPATAELVTEEVFGPVLAVQTFADETEAIAMANDTVYGLAASVWTRDLSRAHRVSAALRAGTVSVNTVDALSAQTPFGGFKQSGFGRDLSLHALDKYTGLKTTWIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV17</accession>
    <name>A0A132PV17_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02670</name>
        <name evidence="3" type="ORF">AWC31_35445</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843384.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35445"/>
    <dbReference type="EnsemblBacteria" id="KWX26155">
        <property type="protein sequence ID" value="KWX26155"/>
        <property type="gene ID" value="AFM11_02670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11933">
        <property type="protein sequence ID" value="ORX11933"/>
        <property type="gene ID" value="AWC31_35445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.548"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046291">
        <property type="entry name" value="DUF6328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19853">
        <property type="entry name" value="DUF6328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="181" mass="19952" checksum="B103D413EF35671F" modified="2016-06-08" version="1">MAADRFDANQRWDEAARHETEAERLDRNWANLLQELRVVQTGVQLLTGLLLTLPFHDGFEEVDHTMRMVYLVTVACSVASTALLIAPVGMHRMLFRRRRLNLLVSGAHRCAYAGLLLLGLTMAGVTQLIFDTVAGRTAGVIAAVTTLVIYLGFWLVLPLAMRSGEPMPADPSPRVGAERGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV93</accession>
    <name>A0A132PV93_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_01360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843617.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26240">
        <property type="protein sequence ID" value="KWX26240"/>
        <property type="gene ID" value="AFM11_01360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.279"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="225" mass="25346" checksum="51781E6A7D48FD0C" modified="2016-06-08" version="1">MKAAGATTTGRVTKTSVFEELRSDILAGRLEPGTKLPFANLVTRFSCSVGTIREALQRLSEQGLVVSEWQQGFKVTEISAEDLADLTEARCEIESMALRFAIERADMEWEAQTVSAHHILDRTPMYDDADPARFTEKWVTAHGAFHDALLLGCPNRRIRTTAMSLRESAELYRRWSAPLHDRERDIAGEHRAIADAVVARDADLATRLLREHIQRTTDKLLQSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVE7</accession>
    <name>A0A132PVE7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_02390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35170"/>
    <dbReference type="EnsemblBacteria" id="KWX26285">
        <property type="protein sequence ID" value="KWX26285"/>
        <property type="gene ID" value="AFM11_02390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.490"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="63"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX26285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="27249" checksum="F492E515AA6541AE" modified="2016-06-08" version="1">MRSAARSLITTFGAVVTILVVWTLFIGVVDVSSYVAKSPADVWTYLVSGADAAANRADIAAHLVRTLVDASYGFVLGLALAAGVSLLFYFSRTVENMFLPTVTALHAIPMVTVAPILVLIFDRGVVGTAVIGAAIVVVPALLTMLHGIRSTPRTDVEMVVAYGGSTLTAFWKVALPHAIPTWFAAARVAVTTSVVGALLAEWLATGQGLGGQMLRDANEFEFARLWSSVVVLTITCIVIYQIVSVIEAAVTARMSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVF3</accession>
    <name>A0A132PVF3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_02615</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843358.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35390"/>
    <dbReference type="EnsemblBacteria" id="KWX26147">
        <property type="protein sequence ID" value="KWX26147"/>
        <property type="gene ID" value="AFM11_02615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.536"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="308"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="243"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX26147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="430" mass="45646" checksum="22CDADA50812B9C1" modified="2016-06-08" version="1">MKVGVVGAGYVGLTTAVCLAEREHDTVCVDIDVDRLQRLTSGEVPVDEPGLPELLAAGLRAGTLRFSGEYGELADRDVVFVCVPTPSGPDGSADLTAIDRVVEQLAATLRPQAIVVLKSTVPVGTTRQVADRLRGTGIRAVSNPEFLRESHAVYDFRHPDRILIGSVDESAADTVQSLYGAGEGETLRMSPESAELSKYASNAFLAVKISYTNSLAQLCSRVGADIGDVTRCMGADFRIGRHFLQPGPGWGGSCLPKDTAALLHTGREHGVALPEVESARTTNQAQTDRIAAALSRSMSAPLAASRIAALGLTFKAGTCDIRDSPALAISGELTKRGAQIVGYDPRVAMIDHAALRRHAVAAVDDPYVATKEADAIVVFTEWPEFRDLDWPQIAEQAPGAVVVDTRNLLEPEMIRDAGLSYLGNGTVSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVH3</accession>
    <name>A0A132PVH3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Strictosidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34715"/>
    <dbReference type="EnsemblBacteria" id="KWX26032">
        <property type="protein sequence ID" value="KWX26032"/>
        <property type="gene ID" value="AFM11_01935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.397"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="48"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="328" mass="34898" checksum="AF217CDE2C1BFE19" modified="2016-06-08" version="1">MSRKPPIDPVRWTPPPVDDLPEFGPAELTIVPMPGDGPEDVVADADGHLWTGLVDGRIVRVSPDGGATVVAETGGRPLGMHVARDGRVLICDSHRGLLALDPATGMLSTLVESVQGRPLMFCSNVTETADGTTYFTESTSRFHYEHFGGAVLEARGSGSLFRLGTDGAVTTLVDGLYFTNGVTATADESALVFAETQGRRLSKYWLTGPQAGTVTPLAVNLPGMPDNISTGSDGRIWVALVSPINAAAEKLAPRSPLLRQLIWRLPDALQPRIKSQVWVVAFDPDSGAAVSGVRCKHPEFGVVTGVCESGGRLWMSTIEYPALAYTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVS4</accession>
    <name>A0A132PVS4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UsfY protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843309.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35300"/>
    <dbReference type="EnsemblBacteria" id="KWX26132">
        <property type="protein sequence ID" value="KWX26132"/>
        <property type="gene ID" value="AFM11_02525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.518"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="101" mass="11032" checksum="E012D5E2A401253D" modified="2016-06-08" version="1">MGDDAKDPVDHARTTRPHAGETMKDTANFPALIMLYLGGASFVACLAAFATSHHGVGIVLACIAAVLFVGSGLWFGIEHWRVRRKERAWNAAHPEVHEQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB54</accession>
    <name>A0A132PB54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859734.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19548">
        <property type="protein sequence ID" value="KWX19548"/>
        <property type="gene ID" value="AFM11_35245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5780"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="128" mass="13904" checksum="A216FDF5C504DDEA" modified="2016-06-08" version="1">MVIDPLELEAAIAAVYAAQLPIPVWWPAEARSAFIEEYASEAACMVLSEVDAIGDRMSDWAARSHVSGADESAMIASAQQVLLDEACSEVQYDLTEMIANRSAQLTAEAVFDHGAPRAQLHVVWSVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBL0</accession>
    <name>A0A132PBL0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859149.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11380"/>
    <dbReference type="EnsemblBacteria" id="KWX19706">
        <property type="protein sequence ID" value="KWX19706"/>
        <property type="gene ID" value="AFM11_34235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5186"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026467">
        <property type="entry name" value="Ser/Gly_Cys_C_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04222">
        <property type="entry name" value="near_uncomplex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="303" mass="30731" checksum="CA2E71549254E5F2" modified="2016-06-08" version="1">MSIGDVIEGYAGAVTGGVKGYLIVLGATAVFAVLWRIAAAPRRPARAQPISATELAFLRSDVAPVVTALAGLRASGRITGRDQVDHTAPAGPEVDLFTARMLERAATDPVHTVPTLFAASQPDLASLEAQLSARGLVRTRAERARMRWGTAPSIAVLLVGVASCVYLVTQVSHRAEDVVPLVVMVIAVVLFGLVVLPRLLTVDRLTRAGRRLLAAEQERLAYLEPAKRPAFATYGPAAVAWSVALFGTGALWAVDADYSTAVQLAGSASGGGHDGGGCGASCGGDGGGGCGSGCGGCGGGCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBM3</accession>
    <name>A0A132PBM3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fusaric acid resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10925"/>
    <dbReference type="EnsemblBacteria" id="KWX19647">
        <property type="protein sequence ID" value="KWX19647"/>
        <property type="gene ID" value="AFM11_34780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5305"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452998" evidence="2">
        <location>
            <begin position="24"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="644" mass="67302" checksum="ABB232D682122810" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBU9</accession>
    <name>A0A132PBU9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase</fullName>
            <shortName evidence="3">SEPHCHC synthase</shortName>
            <ecNumber evidence="3">2.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthesis protein MenD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menD</name>
        <name evidence="5" type="ORF">AFM11_34115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58818"/>
            <dbReference type="EC" id="2.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="3">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPP enzyme family. MenD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859110.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02565"/>
    <dbReference type="EnsemblBacteria" id="KWX19800">
        <property type="protein sequence ID" value="KWX19800"/>
        <property type="gene ID" value="AFM11_34115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5160"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01659">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004983">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00173">
        <property type="entry name" value="menD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="539" mass="56559" checksum="FE0B308DC7DDDC77" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC76</accession>
    <name>A0A132PC76_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858900.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07545"/>
    <dbReference type="EnsemblBacteria" id="KWX19837">
        <property type="protein sequence ID" value="KWX19837"/>
        <property type="gene ID" value="AFM11_33840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5106"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="801"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="880" mass="93475" checksum="BD5ECFB5B2FF5C88" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCH4</accession>
    <name>A0A132PCH4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19682">
        <property type="protein sequence ID" value="KWX19682"/>
        <property type="gene ID" value="AFM11_34690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5285"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="146" mass="16245" checksum="736CB82CF94E2DE8" modified="2016-06-08" version="1">MQCRDVFRKHIYVVDCGQISAGLVIFDQQVAVDCVSHQLLCGADPFHLSQHQINTVAERGGELRHVGAVVESHLVRQIGYQVFPTTLQEGTFERMRRSLISRPRCVDLGRSDAYVDEESMPRHGAVVTVGLKVDHVVESSSFALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCL6</accession>
    <name>A0A132PCL6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_32535</name>
        <name evidence="10" type="ORF">AWC31_19670</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX17044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858130.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19670"/>
    <dbReference type="EnsemblBacteria" id="KWX20085">
        <property type="protein sequence ID" value="KWX20085"/>
        <property type="gene ID" value="AFM11_32535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17044">
        <property type="protein sequence ID" value="ORX17044"/>
        <property type="gene ID" value="AWC31_19670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4835"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="28"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX17044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="120" mass="13541" checksum="D1A151DA125F1FDB" modified="2016-06-08" version="1">MTSPESPAEAEGEVSTPKETIRKALLGYRVFAWATGLWLIALCYEMVLKYIVQVDNPPGWIGVVHGWVYFIYLMFTANLAVKIRWPIGKTIGVLLSGTIPFLGIIVEHFNTRDIKQRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCR1</accession>
    <name>A0A132PCR1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IolT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_31775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857724.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32030"/>
    <dbReference type="EnsemblBacteria" id="KWX20131">
        <property type="protein sequence ID" value="KWX20131"/>
        <property type="gene ID" value="AFM11_31775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4682"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="18"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="472" mass="49818" checksum="F32A198A452CEB28" modified="2016-06-08" version="1">MSRTPDGAPAGGRFLTKLTVIATLGGLLFGYDTGVISGALLYMKDDLGLSAFGEATVVSCLLFPGAAFGALFGGRVADRIGRKRTLLVCGALFLVGALGCAVAPNVQIMVAARIVLGLGVGAAAVTCPLYLAEMAPADRRGRMVTINELMIVTGQMLAFATNALLDRLIHDPHVWRTMLAVAAIPAVALLLGMLVLPDSPRWYGLKGRMSEARAVLGLSRPPVEADAEYDLIVEHTAHMLKSTAPSMSVIRDVPWIRRVVLIGCGLAVVQQATGINTVNYYAPTILEGSGLGVSAALVATIAVGVTSVVTTVIGIILLGFVGRRTMLLIGFAGVAASQAVLSLVFLLPESTTRSYVILACMVAFVAFVQMFIGTCVWLLLAEIFPLSIRGFAMGVAVFVLWCTNAIISFLFPLLNSALGSTGTFALFVVVNIVSWLFVRRYVPETKGTTLEELEERFESHGTAPVAVASRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD36</accession>
    <name>A0A132PD36_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857974.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31665"/>
    <dbReference type="EnsemblBacteria" id="KWX20214">
        <property type="protein sequence ID" value="KWX20214"/>
        <property type="gene ID" value="AFM11_32185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4764"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453151" evidence="1">
        <location>
            <begin position="27"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="368" mass="39381" checksum="6C4405B6F64C97F2" modified="2016-06-08" version="1">MPLTAASLFVTTVIAAGCTPAGPGSAADVDLGSGPPQAGTVKADALKGVTLTFVSYGGIYQDGQMKAAVDPFAQESGARILQDGPTDNSKIKSQVESGNVTWDVIDSTNVFTARNCGDLFVPIDTSIVDVSKIPAGAKTDDCSVPAMQYGLIVIYNTEKYGDNPPKSWADFYDTAKFPGKRAVQGISGEVDPGVFEGALLADGVAPDQMYPLDVDRALRKMSSIRDDSVFWTTGAQAQQLVESGQVDMAVLWSGRAYAAVKNGAPFAPMWNQWMPEADTIAVPKNAKNPKASMALINFYLGAQQQAKLAELTSYSPVNVDSKPQLDDLAKSYLTTTPEREKDKFPIDLPYWAENHDKLVTAYTDWLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD65</accession>
    <name>A0A132PD65_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_31455</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857521.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25610"/>
    <dbReference type="EnsemblBacteria" id="KWX20256">
        <property type="protein sequence ID" value="KWX20256"/>
        <property type="gene ID" value="AFM11_31455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4197"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05801">
        <property type="entry name" value="PGM_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005852">
        <property type="entry name" value="PGM_a-D-Glc-sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01132">
        <property type="entry name" value="pgm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="41"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="217"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="329"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="484"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX20256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="553" mass="58512" checksum="74CF7D0D457A7676" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD83</accession>
    <name>A0A132PD83_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_31705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857642.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26325"/>
    <dbReference type="EnsemblBacteria" id="KWX20295">
        <property type="protein sequence ID" value="KWX20295"/>
        <property type="gene ID" value="AFM11_31705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4245"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="271"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="391" mass="40345" checksum="F9A4EE5D2AE0A1C7" modified="2016-06-08" version="1">MPTPVIVGAARTAIGRSFKGTLVNTPPEALITTVLPEVVRRAGIAPEAIDDLIFAESNYGGGDIARYAADALGWQSVPGQSVNRHCAGSLTSIGNASAQIASGMERVLVAGGVQSLSSSPLMKWRVPGPELTFIEPWMTPTHVETPDAPMRDMSITVGWNTAQAVGITREEMDAWAARSHQRAIAAIDAGKFLAEIVPLKVTQPDGSVTEFSVDEHPRRGTTAEKLAELKVLHPEIEGFSISAGNSSGTNDAAAAVALVDADYAAAENLGVLATVKAWGAVGVAARDTGLGGVNVIGKVLDRAGLKPSDVALWEINEAFASVPIAACREYGLDEELVNFSGSGCSLGHPIAASGARMVTTLVYELQRRGGGIGVAAMCAGGGQGGAVVIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDG4</accession>
    <name>A0A132PDG4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="5 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_30975</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="5 10"/>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26695"/>
    <dbReference type="EnsemblBacteria" id="KWX20375">
        <property type="protein sequence ID" value="KWX20375"/>
        <property type="gene ID" value="AFM11_30975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4097"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026459">
        <property type="entry name" value="RNR_1b_NrdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013554">
        <property type="entry name" value="RNR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08343">
        <property type="entry name" value="RNR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04170">
        <property type="entry name" value="RNR_1b_NrdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX20375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="693" mass="79211" checksum="F5D0105156B577A5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDJ0</accession>
    <name>A0A132PDJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857288.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26815"/>
    <dbReference type="EnsemblBacteria" id="KWX20396">
        <property type="protein sequence ID" value="KWX20396"/>
        <property type="gene ID" value="AFM11_31105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4125"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="223" mass="23102" checksum="E225A15043A5D38B" modified="2016-06-08" version="1">MNEFVSVVIGAVPEQAGVATLLLSRPPTNALTRQIYREISSAAAELAERADVAAVILFGGHEIFCAGDDVPELRTLDVEEEAAADHALQRCIEAVAAIPKPTVAAITGYALGSGLTLALAADWRVSGDNVKFGSTEILAGLAPRGGGGTRLAGAIGPSKAKELVFSGRFVGAEEALGLGLIDEMVAPDHVFDAALAWARRFVDHPVDVLAAAKAAVDRVVDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDL4</accession>
    <name>A0A132PDL4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxybenzoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_31015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857384.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="KWX20425">
        <property type="protein sequence ID" value="KWX20425"/>
        <property type="gene ID" value="AFM11_31015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4106"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
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            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
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            <begin position="133"/>
            <end position="157"/>
        </location>
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            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="439" mass="45809" checksum="5A07227E6E7E8CCC" modified="2016-06-08" version="1">MNLKRWGVVGLCFAIALLDGFDTQSIAFIGSSIAEEFSMATAEMTAVITASTVGMALGAITLGSIGDRIGRKRAILLALSIFGFFSLLGAFAQAPWQIVLLRFLIGLGMGGATPSLLALAAEYSPERSRKLSMTLVLLGLPGGAMLGGVVAAAWLPALGWRGIFLLGGLLPLLLLAIVVVFLPESPSYLATRDDAASQDKARELLRRITGASIPDDAILAAEQREQNAGSVRALFASDYRTSTITICAIYLANWIAWFLLLQWTPTALHQAGLSKEQAASGTIVVNGAFIVFSFLVTALLSRVPIRRLLLGMFGLGIAVALGLAVSGSNWTLTFALIAVAGLGIGGQQLVLNYLIAETYPTQLRGTATGFSIGVGRTGSIIGSALGGWLLGSFGVGGYFGLIAVPLAIAALATLMLRPQHRGLSSPEATDESAVAVESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDS7</accession>
    <name>A0A132PDS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20483">
        <property type="protein sequence ID" value="KWX20483"/>
        <property type="gene ID" value="AFM11_30390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3977"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="223" mass="24287" checksum="41B80BF8201D15A0" modified="2016-06-08" version="1">MTHAEPAHPVATLIRPEDAAAYLQQMDIDVGDVHAAIEAGDIGARSIGEHHPITGAGLTRWIQVVGMLRRRLASGRNWRGDNPRNRPISRHTSKPYTLSTVGGTDATGIVDHARGPLAANKKGRATAEAVTGTLTLIEVDKLLPQARTFDAATTPPSGNWFLVYYRDDEEIRVEISLPLGFSEGQFTGWLVRVILDSWTPPEPVTRPLDVGGQDVDFEVREVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDS8</accession>
    <name>A0A132PDS8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856922.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20488">
        <property type="protein sequence ID" value="KWX20488"/>
        <property type="gene ID" value="AFM11_30425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3985"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="143" mass="15223" checksum="2C389476CDC4FD3B" modified="2016-06-08" version="1">MSRRYFVFSTQHRDSQPVWTCLAAATVVGAALLAVFGVPTVDLHGPLHYLGVMDPLCGGTRSVYLTLHGQLGEAVRYNPAGPLVLAAAAVLLARAAAGCLFGRWLSIRIAPRILLPVALVALVALEVNQQMHAVLLTQSWSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDU6</accession>
    <name>A0A132PDU6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_30550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856984.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00555"/>
    <dbReference type="EnsemblBacteria" id="KWX20508">
        <property type="protein sequence ID" value="KWX20508"/>
        <property type="gene ID" value="AFM11_30550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4010"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13896">
        <property type="entry name" value="CuRO_3_CopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034279">
        <property type="entry name" value="CuRO_3_CopA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453199" evidence="4">
        <location>
            <begin position="35"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="186"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="403"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="510" mass="53822" checksum="DD7735CAAD9F03FC" modified="2016-06-08" version="1">MAEADSKAGVSRRGFLLATAALGATVVAGCQRNAATSASTDASPDAIAAAEARRPHSGRTVSTTLTAERTRVDLGGRVAETIAYNGTVPGPLVRASVGDELKVTLRNRLGHATSVHWHGIALRNDMDGASPATPDVDDGSEFTYRFSLPHPGTYWAHPHVGLDADTGLYFPVIVDDPAEPGRYDAEWVVMLDDWTDGVGSSPAQIYDRLRSGSGGGHDMPGMGDMPGMSGGAGMGSMGAASDLLGGDAGDVDYPMYVINGRNAQAPHSFRARPGQRIRIRFINAGSDTAFRVALADHPMTVTHTDGFPVVPTEVDALLIGMGERYDVTVTAADGVFPLVAAAEGKNASTRALLVTGAGSAPSPDFAPPELQGRVGTVSSFTATPQATFPESPTGAELPAELGGSMMNYDWTINGLAFSKTRPLAVRVGQRAALTFTNSSMMWHPMHLHGHTFQVVGDDGRLGARKDTVIVLPMQKLRVTFVADNPGVWMLHCHNTYHQEAGMMTRLDYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF00</accession>
    <name>A0A132PF00_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856496.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25005"/>
    <dbReference type="EnsemblBacteria" id="KWX20572">
        <property type="protein sequence ID" value="KWX20572"/>
        <property type="gene ID" value="AFM11_29665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3825"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="335"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="407" mass="42742" checksum="7183DD089106C0DC" modified="2016-06-08" version="1">MSAPRHVAVVGGSLAGLRAAEQLRALGHTGPITVFSAEQHFPYNRPPLSKEALANPDSVAPDELAGRLAFRRRASVADVDFRFGAYVRGADLGAHTITVDSGETVSYDGLVVATGLRPRRLTVPGPERGRHVLRTVEDCLGLRNALPAHGRVVVVGGGFIGCEVAGTLSALGHHVTVVEPVGPPMQRVLGTELATAIQRHHTAKGIDFVIGTGVAAFTGDEVVTGVELGTGETLSADVVVEAVGSVCNVEWLDGHGLDLSDGVLTDNHLAVVGAADAVAVGDLARFPNPLFDDVARRVEHWSIPSDTAKRAAATLSGRLAGEPDDTTPFAPIPAFWSDQLDLRLQSYGSPALADEIRFDEGTLDDLTGGVIATYHRDDRHVGTVAVNLSPARCRVLREAFTAVDVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFA8</accession>
    <name>A0A132PFA8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26955</name>
        <name evidence="2" type="ORF">AWC31_06805</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855235.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06805"/>
    <dbReference type="EnsemblBacteria" id="KWX21028">
        <property type="protein sequence ID" value="KWX21028"/>
        <property type="gene ID" value="AFM11_26955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09908">
        <property type="protein sequence ID" value="ORX09908"/>
        <property type="gene ID" value="AWC31_06805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3265"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX09908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="249" mass="26372" checksum="B9AB530E007150AC" modified="2016-06-08" version="1">MSKLEGKSAVVAAGAKNLGGLISTTLASRGVNVAVHYNSASSEPDADKTVAAVQAAGVKAVKVQGDLTVPANVEKLFDTAIDAFGSVDIAVNTVGKVLRKPIGETTEAEYDSMFDINAKAAYFFLQQAGTRLNDNGSIVTIVTALLAAYTDGYSTYAGSKSPVEHFTRAASKEFGVRGINVNNVAPGPMDTPFFYPQETPERVEFHKSQGMGNRLTEITDIAPLVVFLTDEGHWINGQTIFANGGYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFY2</accession>
    <name>A0A132PFY2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division protein FtsQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsQ</name>
        <name evidence="10" type="ORF">AFM11_27500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential cell division protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">Localizes to the division septum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FtsQ/DivIB family. FtsQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855504.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07435"/>
    <dbReference type="EnsemblBacteria" id="KWX21117">
        <property type="protein sequence ID" value="KWX21117"/>
        <property type="gene ID" value="AFM11_27500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3374"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00911">
        <property type="entry name" value="FtsQ_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005548">
        <property type="entry name" value="Cell_div_FtsQ/DivIB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026579">
        <property type="entry name" value="FtsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03799">
        <property type="entry name" value="FtsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="9">
        <location>
            <begin position="119"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="309" mass="32970" checksum="75CB3EC6E1E3F4E3" modified="2016-06-08" version="1">MTEPGPQAGPESTAAESNPAEPEHAQAESTMPLAASEDYEGPRRRARRERAERRAARDRAIAIEQARREAKRRVDGSSAEAPKTLARGTIRGLKVLLWTALASVLAVALGLVLYFTPIMSARNVVVSGLAALPQEEVLAAAAVVPGTPLLQINTDAVAERVATIRRVATARVQREYPSTLRITVVERVPVVVKDYPDGPHLFDRDGVDFATEPPPPALPYLDADNPGPNDPATQAALEVMLALPPEVVGQVGRVAAPSVASITLTLTDGRVVVWGTTDRTKEKALKLAALLTQPGRTYDVSSPDLPTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG75</accession>
    <name>A0A132PG75_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_25645</name>
        <name evidence="12" type="ORF">AWC31_36250</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854457.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36250"/>
    <dbReference type="EnsemblBacteria" id="KWX21313">
        <property type="protein sequence ID" value="KWX21313"/>
        <property type="gene ID" value="AFM11_25645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12061">
        <property type="protein sequence ID" value="ORX12061"/>
        <property type="gene ID" value="AWC31_36250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2993"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="37"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="245"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX21313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX12061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="508" mass="55077" checksum="E4A2F36F30E44811" modified="2016-06-08" version="1">MTQLNPSFAKLGVRDEIVRALADNGIEHPFAIQELTLPLALAGDDLIGQARTGMGKTYAFGVPLLHRVSTDESRPLTGTPRALVVVPTRELCLQVYDDLAAASKYLSGPDRKFTVTSIYGGRPYEPQIEALRKGVDVVVGTPGRLLDLAQQGHLQLGGLSVLVLDEADEMLDLGFLPDIERILRLTPDDRQSMLFSATMPDPIITLARTFMNQPTHIRAEAPHSAATHDTTEQFAYRAHALDKAELVSRILQAEGRGATMIFTRTKRTAQKVSDELAERGFKVDAVHGDLGQGAREKALKSFRTGAVDVLVATDVAARGIDIDDVTHVINYQCPEDEQAYVHRIGRTGRAGKTGVAITLVDWDELPRWEMIDKALDLGCPDPAETYSSSPHIYEELGIPTDATGNVGAARRSGAKRRSDDADGSETRISSSADSADRPARTRNRTRRRTRGGKPVTGHVEGAATSDEGDAAPVAESDDTAGEASHAGRRRRRRRPRKTEAATQVATTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG99</accession>
    <name>A0A132PG99_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854610.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35935"/>
    <dbReference type="EnsemblBacteria" id="KWX21365">
        <property type="protein sequence ID" value="KWX21365"/>
        <property type="gene ID" value="AFM11_25965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3058"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="209" mass="21941" checksum="F79C49A9604777E3" modified="2016-06-08" version="1">MLDLILPLECGGCGAPSTRWCATCAKELTVRDDEPHLITPRLDPGVPVFALGRHAGARRRAIVAVKEKGRADLVSPLASVLRTGLDRLVTWGVVGAPLTVVPAPTRRTAARRRGGDPVTRIAASAATGLPGVGVVPALRLRPWVRDSVGLSGVDRQRNIAGRVRIVKHLTGEVLLVDDIVTTGATAAESVRTLRTAGIYVSAVLAIAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH09</accession>
    <name>A0A132PH09_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_24125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853598.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24005"/>
    <dbReference type="EnsemblBacteria" id="KWX21620">
        <property type="protein sequence ID" value="KWX21620"/>
        <property type="gene ID" value="AFM11_24125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2184"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PTHR18896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="530" mass="59441" checksum="B3F38BF3002CA275" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHB7</accession>
    <name>A0A132PHB7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26155</name>
        <name evidence="4" type="ORF">AWC31_35740</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854699.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21392">
        <property type="protein sequence ID" value="KWX21392"/>
        <property type="gene ID" value="AFM11_26155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11982">
        <property type="protein sequence ID" value="ORX11982"/>
        <property type="gene ID" value="AWC31_35740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3096"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="115" mass="12947" checksum="A1EBE7B4B1A4F56C" modified="2016-06-08" version="1">MGSTLAAIITLLGLLGWHLRTRRHPSWSVSSDARFYIYSGYPLVAIAVFWLTKATTGTDWEWVIGNVWAFAAMVMFVRGFNALSVTTAQQYTTSRTIESIEKTRETNGAQTRRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHD3</accession>
    <name>A0A132PHD3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24490</name>
        <name evidence="3" type="ORF">AWC31_23630</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853767.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21674">
        <property type="protein sequence ID" value="KWX21674"/>
        <property type="gene ID" value="AFM11_24490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15559">
        <property type="protein sequence ID" value="ORX15559"/>
        <property type="gene ID" value="AWC31_23630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2259"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025492">
        <property type="entry name" value="DUF4383"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14325">
        <property type="entry name" value="DUF4383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="145" mass="15779" checksum="C7B966ECB4C04505" modified="2016-06-08" version="1">MRRWSFAQWGLLLISLFHVVQAIIGFIVEPSFATGPDAPTAQILGMDYNGWHAVAGLALFGPGLVLCWRRSWAVLYLLLAAVAGALPGIWAFFSNQVAYIFAFPNNVTDAIVHLVTAAVMLAIAAVQIRRDGGLRNSLAELRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHE1</accession>
    <name>A0A132PHE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853620.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23955"/>
    <dbReference type="EnsemblBacteria" id="KWX21627">
        <property type="protein sequence ID" value="KWX21627"/>
        <property type="gene ID" value="AFM11_24160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2191"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024188">
        <property type="entry name" value="GltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_synthase" evidence="4">
        <location>
            <begin position="143"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="525" mass="55920" checksum="6255A246056A2E5B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHS7</accession>
    <name>A0A132PHS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbon-phosphorus lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852665.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08955"/>
    <dbReference type="EnsemblBacteria" id="KWX21900">
        <property type="protein sequence ID" value="KWX21900"/>
        <property type="gene ID" value="AFM11_22255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1801"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010306">
        <property type="entry name" value="PhnJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06007">
        <property type="entry name" value="PhnJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011468">
        <property type="entry name" value="PhnJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00379">
        <property type="entry name" value="Phosphonate_metabolism_(PhnJ)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="31610" checksum="91EA9067B84453BF" modified="2016-06-08" version="1">MNRPHTVAELAAAHGRPQAYAYLDEDTKRNVRRAILKALAIPGWQVPFASREMPVARGWGSGGLQVTLSLVGPTDVVKVIDQGDDHSVNAAAMRSLIAGSASCEATTDTAQATIVQSRHRIPEVELRGDQVLVLQVPHPEPLRRVVPDELTAKQHHADGDYTPAWLDLYDDQTRLGGPRTGADHPVLIGDSRLMSPSPIPRHDVLRLDQRPHPILLGAGRRARLTALPPYTSVRPLAFDDCPLEPERADGPCCRCGSTTSYRVPTGGADTALVWQCSDVDACRVRSNGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHZ4</accession>
    <name>A0A132PHZ4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAA_hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852714.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21923">
        <property type="protein sequence ID" value="KWX21923"/>
        <property type="gene ID" value="AFM11_22405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1831"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="281" mass="29093" checksum="A2FBC94A078EF2A5" modified="2016-06-08" version="1">MRLRTVLLDDHPIACVALADGRLARVDKVLAGAPADLLALLAADTLEALAAAVAAGVAEDACVAGDTPALAPWTRPRKILGIGLNYGAHAGDLGEQAPRTSPASFLKGDHTIVGPGDPIVVPPGIGKVTSEAELGLVIGKPCYQVSVEDAMSYVAGVVPVLDQTAEGILLENPRYLTRVKNYPSFFAFGPDLITLDEVLAHGPLEKLRVATIHNGAVHREDTVSGMTFSPAELLSFHSQVMPFYPGDILSTGTPGAVGIAPGDIVRCELGDGLASLTNPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI09</accession>
    <name>A0A132PI09_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Precorrin-6Y-methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_22845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852863.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08355"/>
    <dbReference type="EnsemblBacteria" id="KWX21998">
        <property type="protein sequence ID" value="KWX21998"/>
        <property type="gene ID" value="AFM11_22845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1922"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="392" mass="41894" checksum="97B95493062E9A3C" modified="2016-06-08" version="1">MIIVVGIGADGMTGLSAAARAELARAKVVYGSRRQLDLLDDTVTADRRAWPSPMLPALRTLLDGADQDVHVVASGDPMLHGIGSVLIRMYGPDAVAVLPHVSSVTLACARMGWSVQDTEIISLVTAQPHTAVRRGGQAVVLSRDSTTPAALAKLLAETGRGDSELTVLEQLGGPRELRRSASAREWAMRPPRDVDALNVMAVRYLPDDRMLATLPDDVFDHDGQITKQAMRAVTMAALAPRPGELLWDVGAGSGSIAIEWCRSGAGCRAVAFERDDARRDRITRNAAAFGARVELRDGAPEAFDGADQPAAIFIGGGVTQAGLVDACYERLPTAGRLVVNAVTVESEALVAQWYSKEGGELRRYQHYRGGAVGGFTAWRPALPVTQWSVVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI79</accession>
    <name>A0A132PI79_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphonate metabolism protein PhnM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852659.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08970"/>
    <dbReference type="EnsemblBacteria" id="KWX21897">
        <property type="protein sequence ID" value="KWX21897"/>
        <property type="gene ID" value="AFM11_22240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1798"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012696">
        <property type="entry name" value="PhnM"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038971">
        <property type="entry name" value="PhnM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="394" mass="40615" checksum="BB3D19F13B85ADDE" modified="2016-06-08" version="1">MAQTVIEGVTLVPGGGRPIIPSAAVVLDADGRVTEISEAAGANGAGDLYLVPAGVDLHLDNLVQRRRPRATVSLDHEAVISVLDAECAAAGIGTVCVAARCEDSPRKGIEIADAAVLAAVVEELAPHLACDWRIHARVELTDDRSLDALTAVLSASSRVALISLIETSAQRSRFATLAETRAFYAQDWGVSEAEVEAVFTVDAGRLSQIAERRKEVAALAVSRNIALASHDDRTPEHIDEAFEVGARVAEFPLTIEAARHAADLGMNVVLGAPNAIRGRSTSTGNVLASDAVAAGVCDVLCSDYLPSALLAAPLALASGGAAPLSTAIDLVSVNPAGVLGLPHAVIEVGQPLTASLRRIGSDTARSQVGMALWRAGQQVFGRQSLGSTFAAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI90</accession>
    <name>A0A132PI90_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852933.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08170"/>
    <dbReference type="EnsemblBacteria" id="KWX22031">
        <property type="protein sequence ID" value="KWX22031"/>
        <property type="gene ID" value="AFM11_23040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1959"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="28501" checksum="8CF22A978E824362" modified="2016-06-08" version="1">MIGCHYRRTGSDGEFQLFESTADTRSNWDPAIQHGSPPLALLTKAIEELMAPSGLRIGRLTLDILGAIPVAPVRVRAWVDRPGARISMAVAEMAAARPDGTWRAVAKVTAWLLATSDTSDVATDRHPPLVEGEAAEVAHNWEGAPGYLDTVSWRRQRTAEGEAAEVWMSPLTPVVDDEETTAIQRLALVVDSANGVGAALDPQRFVFMNTDTSVHLHRLPEGSDFALRARGSIGPDGIGATTAEIFDRKGFIGTSAQTLLVMRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIA5</accession>
    <name>A0A132PIA5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852331.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04265"/>
    <dbReference type="EnsemblBacteria" id="KWX22080">
        <property type="protein sequence ID" value="KWX22080"/>
        <property type="gene ID" value="AFM11_21450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1638"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CHK" evidence="1">
        <location>
            <begin position="141"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="379" mass="40791" checksum="FBF1C9F97DE797D2" modified="2016-06-08" version="1">MLTTARRVTPALGLAAHLGHGVQRIATDATVGRMRGIPRRVADLDAGHLSRLIGRTVRSVAVIDGDAGTSSRARLALVGDDVPESVFVKMPAETAATRLMGELGRLGQTEVRFYEQLAPGLPGVPRSYGSAFDPLTGRFALVLEDLALQKCEFPDTLHPLDKDRAGLTVELLARLHAAFWGRLPERAGSGRLGWLYSASGDHTSLLTGSLLKMSTRRLAERTDIPVAGGRFIDENYRAAAQLLDRPPHTVMHGDAHPGNLYFRGGAVGLLDWQAVRRGHPGRELAYTLITSMTTTDRQSAERDLLDTYRSALAAAGGPGLDLDDLWERYRMGALYAYTAPVITAGMGGMQAEGIALEGARRGVAALEDLETVALLKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIJ3</accession>
    <name>A0A132PIJ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_21790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852436.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04595"/>
    <dbReference type="EnsemblBacteria" id="KWX22131">
        <property type="protein sequence ID" value="KWX22131"/>
        <property type="gene ID" value="AFM11_21790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1706"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="381"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="583" mass="63911" checksum="BA03A18EA5E9A51E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIL8</accession>
    <name>A0A132PIL8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_22090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852541.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22185">
        <property type="protein sequence ID" value="KWX22185"/>
        <property type="gene ID" value="AFM11_22090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1766"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="6">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="173"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="294" mass="32387" checksum="5F95C551F164DD74" modified="2016-06-08" version="1">MTAAEHTDEELRFDDSGLNTWTDEERFEVTRERLAEYAAATNDPIPAHRSGNVAPPVFAIVPVFEALLVPAVDVLPVELIPRVVHGEQDFHFHRPIKPGDKLVSRGKMIGYEGLENGTRAAIYLECRTEEGELVNEQYVTTFVRGFDAGKAVGRLSPNHRFDESLRTGAPAATVTQHVDDDQTFRYSPAAGDPMPIHLDEEVARDAGLPGIIAHGLCTMAFTSWAVLTELAGSDVHRLRRFAVRFSKMVLPGDDLETRIWRTGSTDGVTSYAFETARGSDLVITDGLAEIIEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIS6</accession>
    <name>A0A132PIS6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852592.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22211">
        <property type="protein sequence ID" value="KWX22211"/>
        <property type="gene ID" value="AFM11_21525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1653"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="157" mass="17275" checksum="1D0B1EE10836AE03" modified="2016-06-08" version="1">MGIVTTSSETAFTQSAETVYDFVTNPANWTKTYPGSAHIGDLPQRLPLQVGDTWTEAGPDGAQIYTWHLAIAMRPRMWVFNSVGRLGHDRDGNGGMEGRITVQYQFTRPGADITLFSRTMTIEAYKDSPLPDALFRVVNPANIDKYHAAVARELAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIX0</accession>
    <name>A0A132PIX0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_20975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852144.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22308">
        <property type="protein sequence ID" value="KWX22308"/>
        <property type="gene ID" value="AFM11_20975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1535"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="187"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="391" mass="42418" checksum="A6E8639F01EF54F9" modified="2016-06-08" version="1">MAGRPPLRIGSHGKITRQYQGGGVWLARCRYRDSDGVTRIVQRVGPADEHDKHGKLAEDLLVEALGQRRPPVSGGVDTIGPDTTVMALVAKHLMRLAEDGRSPATLATYRFASDRLAKFLGGVRVREATTARMDAALRSMRTAHGPTMAKQSKTILRGGLQLAVMANAIGSNPVRDVDPIKPKAAPKGAVALTASQLRALLLGVQNSQFCQDHDLADPITLLVATGLRRSELLALQWSDFDTEAGTLSVTGKLVRAKGHGLQRLEDAKSAAGLRTVALPKFAVDMLDERRGRAYVGEQPMIFPATSGTWRDPNNFGKQWRNVRETLGVPEVTSHSFRKTVATLIDDSGLSARVGADQLGHSRVSMTQDRYMARGRVHTEVADLLDRAICDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIX8</accession>
    <name>A0A132PIX8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22309">
        <property type="protein sequence ID" value="KWX22309"/>
        <property type="gene ID" value="AFM11_20980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1537"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="70" mass="7633" checksum="A39AB21E97998859" modified="2016-06-08" version="1">MMTFVKAHETVRPADVAAHYGIASNDAARILGHLADRGLVARIKRGVYTADRELARRVLSAKLDSLMATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ43</accession>
    <name>A0A132PJ43_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22355">
        <property type="protein sequence ID" value="KWX22355"/>
        <property type="gene ID" value="AFM11_20540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1445"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="182" mass="20502" checksum="4D639EE3157F0261" modified="2016-06-08" version="1" fragment="single">MIVVGADVHKRSHTFVAVNEVGRRLGEKTVKATTEGHQAALIWAREQFGTDLIWGIEDCRNMSARLERDLLGGGQKVVRVPTKLSAQTRKSARTRGKSDPIDAEAVARAVLREPDLPVACHDETSRELKLLTDRRDILVVQRTSAINRLRWHVHELDPEQAPAARKLKLTTHQQALQDWLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ94</accession>
    <name>A0A132PJ94_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureG</name>
        <name evidence="6" type="ORF">AFM11_19895</name>
        <name evidence="7" type="ORF">AWC31_28620</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000016">
        <property type="protein sequence ID" value="ORX14063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851861.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28620"/>
    <dbReference type="EnsemblBacteria" id="KWX22419">
        <property type="protein sequence ID" value="KWX22419"/>
        <property type="gene ID" value="AFM11_19895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14063">
        <property type="protein sequence ID" value="ORX14063"/>
        <property type="gene ID" value="AWC31_28620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1313"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="29"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX14063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="228" mass="24326" checksum="BFA3148DE5DA979F" modified="2016-06-08" version="1">MPPHFLDGEPHAHTERPKRIRQPGEPLRIGIGGPVGSGKTALVAALCRQLRDELSLAVLTNDIYTTEDADFLRRHAVLPDERIAAVQTGGCPHTAIRDDITANLDAIDDLIEGNPALDLILVESGGDNLTATFSSGLVDVQIFVVDVAGGDKVPRKGGPGVTYSDLLVVNKTDLAPLVGADLDVMRRDAAKVRQDRPTVLISLTEDPAAGPVLAWVREQLEVARAQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJG2</accession>
    <name>A0A132PJG2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_21905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04710"/>
    <dbReference type="EnsemblBacteria" id="KWX22152">
        <property type="protein sequence ID" value="KWX22152"/>
        <property type="gene ID" value="AFM11_21905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1729"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01451">
        <property type="entry name" value="vWA_Magnesium_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041702">
        <property type="entry name" value="BchD/ChlD_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="441"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="622" mass="65936" checksum="449EA4B83B249975" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK06</accession>
    <name>A0A132PK06_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein glxC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851758.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15585"/>
    <dbReference type="EnsemblBacteria" id="KWX22679">
        <property type="protein sequence ID" value="KWX22679"/>
        <property type="gene ID" value="AFM11_19500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1233"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012061">
        <property type="entry name" value="Glu_synth_lsu_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006519">
        <property type="entry name" value="GOGAT_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXGXG" evidence="1">
        <location>
            <begin position="27"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="24022" checksum="FC7E4054121C6816" modified="2016-06-08" version="1">MDQVTLTATGFDLRTTPLREVNTALHQPGIEGEFVIEHPAGAHNVAVGLNAPVTVTIEGHVGYYAAGMNQLADVTINGNAGTGVAENMMSGTVRVKGNASQSAGATAHGGLLVIEGDAAARCGISMKGVDIVVGGDIGHMSAFMAQAGRLVVRGNAGEALGDSIYEARIYVRGTVASLGADCIAKPMRPEHHAELADLLRAAGFSGDDTAEYTRYGSARNLYHFHVDNASAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK84</accession>
    <name>A0A132PK84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22607">
        <property type="protein sequence ID" value="KWX22607"/>
        <property type="gene ID" value="AFM11_19080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="79" mass="8834" checksum="E89C68BF918D8213" modified="2016-06-08" version="1">MAAAAYLVLRASMRDHNAAHDALHPTNHRRTHAALGEFDRELPFASGQRTVKSDQGGFDSVHQVSEHADALRPWWHLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKA3</accession>
    <name>A0A132PKA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851894.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28450"/>
    <dbReference type="EnsemblBacteria" id="KWX22452">
        <property type="protein sequence ID" value="KWX22452"/>
        <property type="gene ID" value="AFM11_20065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1349"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="212" mass="23371" checksum="F597566D4F121FEA" modified="2016-06-08" version="1">MIDVTHQVNAVRRTVGTRVLEAGEAHVITLGQTYPTDAADLWDALTNIERIPRWFLPITGELRVGGQYQLKGNANGTVLSCDPPREFTATWEFGGDVSWIEVRVFDEGPDRSRFELDHIAHVDDDTWRQYGPAAVGIGWDLGLVGLAIHLETGEAIEAGFEETWSASDDGKRFVTEAAGQWQQALVACGADPEWARAATERCAAFYQGKPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKE1</accession>
    <name>A0A132PKE1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate lyase</fullName>
            <ecNumber evidence="1">4.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Isocitrase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Isocitratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_20295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851936.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11420"/>
    <dbReference type="EnsemblBacteria" id="KWX22492">
        <property type="protein sequence ID" value="KWX22492"/>
        <property type="gene ID" value="AFM11_20295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1393"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="PTHR21631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="765" mass="85240" checksum="FBCF7E24E0B4314A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKH5</accession>
    <name>A0A132PKH5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851270.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12195"/>
    <dbReference type="EnsemblBacteria" id="KWX22849">
        <property type="protein sequence ID" value="KWX22849"/>
        <property type="gene ID" value="AFM11_18125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.982"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041605">
        <property type="entry name" value="Exo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18305">
        <property type="entry name" value="DNA_pol_A_exoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="237"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="415" mass="45207" checksum="2E8B6DFA4633BB59" modified="2016-06-08" version="1">MTDGDTEQTEPVEADATPLLAPAGGVPDVCVTAEEISSAAAVLARGSGPFAIDAERASGFRYSNRAYLVQIRRSGAGTALIDPVNHGGSPIDALAPVSATLAQDEWVLHAADQDLPCLAEIGLRPGKLYDTELAGRLAGFERVNLAAMVQRLLGLQLMKGHGAADWSKRPLPPEWLNYAALDVEVLLELRDAIAAVLEEQGKTDWAAQEFEYLRTYVASPTRRDRWRRTSGIHKVRNPRALAAVRELWTTRDNIARSRDIAPGRILPDAAIVNAATVDPKTVDELTALPIFGGSKQRRSAQIWLDALKRARENPDPPQTAEAPNGPPPAARWARRKPEAAARLEAARAALAELSERVSVPTENLITPEVVRRLCWDWQPVADVATAIEEFLVANQVRPWQRELTVPVLTSALKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKS7</accession>
    <name>A0A132PKS7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lexA</name>
        <name evidence="17" type="ORF">AFM11_17720</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851132.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11840"/>
    <dbReference type="EnsemblBacteria" id="KWX22787">
        <property type="protein sequence ID" value="KWX22787"/>
        <property type="gene ID" value="AFM11_17720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.899"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="16">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="15">
        <location>
            <begin position="124"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KWX22787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="25599" checksum="319D660F977663F4" modified="2016-06-08" version="1">MSDDSSDITDGSPDSPAGTEGAGRPRAVDGGLTERQRTILEVIRASVTSRGYPPSIREIGDAVGLTSTSSVAHQLRTLERKGYLRRDPNRPRAVDVRAADDPATPLVSTDVAGSDALPEPTFVPVLGRIAAGGPILAEEAVEDVFPLPRELVGEGSLFLLKVVGDSMVDAAICDGDWVVVRQQNVADNGDIVAAMIDGEATVKTFKRTRGQVWLMPHNPAYDPIPGNDAAVLGKVVTVIRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKZ1</accession>
    <name>A0A132PKZ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850617.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19905"/>
    <dbReference type="EnsemblBacteria" id="KWX22963">
        <property type="protein sequence ID" value="KWX22963"/>
        <property type="gene ID" value="AFM11_16415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.631"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="373" mass="39423" checksum="DD3B67F1B2B96FE2" modified="2016-06-08" version="1">MRILVAGATGYVGSRLVTALLADNHDVVVGSRSPARLTDFGWYPDVTAVALDADDPDSVACAFAQAGPIDVVYYLVHGIGQPGFREADNQAAANFASAARDARVSRIVYLGGFVPDDDALSEHLAGRAEVAHALTVDGGPEVVWLGAAMIIGAGSTSFEILRYVGDRFPVMPMPRWMANPMDPISIRDVLYYLVAAGDAERLPAGAYDIYGPQRTTYRDLLATYARLAGKRRIGIPVFGVATDLASRVSAIALPVPDGLAADLTASLDHPMTAAGDGIRAFVPDPPGGLLGVDDALASALASRQRRPVNELADPHHLADTDPDWAGGDRSRIRQFTPPFVRPALSLLPPMPGPVAAVLRSGLDVVFSLVVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL10</accession>
    <name>A0A132PL10_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850657.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22983">
        <property type="protein sequence ID" value="KWX22983"/>
        <property type="gene ID" value="AFM11_16535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.656"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="9"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="184" mass="19024" checksum="9C178FBEA39F1D54" modified="2016-06-08" version="1">MTNTDGAITVLAVVGSLRSASINKQIAQVAVDNAEDGIAVRLYEGLGELPFYNEEIDTAALTGPAQTLRAAVARADAVLVVTPEYNGTIPAAVKNAIDWLSRPYGNGALNGKPVAVIGASQGQYGGVWAHDEARKSLGIAGARVIDGLTMSLPTQVLESKDPGQITDVVNAVGEVVRKLAVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL53</accession>
    <name>A0A132PL53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_17085</name>
        <name evidence="7" type="ORF">AWC31_01655</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850854.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01655"/>
    <dbReference type="EnsemblBacteria" id="KWX23076">
        <property type="protein sequence ID" value="KWX23076"/>
        <property type="gene ID" value="AFM11_17085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13259">
        <property type="protein sequence ID" value="ORX13259"/>
        <property type="gene ID" value="AWC31_01655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.770"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX13259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="295" mass="31911" checksum="E674E01941746217" modified="2016-06-08" version="1">MTTTENRRSERRLAFALIAPAVLLMLAVTAYPIGYAVWLSLQRYNLAEPDDTAFVGFANYQTVLTDRYWWTAFAVTLAITVISVAIEFVLGMALALVMHRTIFGKGVVRTAVLIPYGIVTVAASYSWYYAWTPGTGYLANLLPEGSAPLTEQLPSLAIVILAEVWKTTPFMALLLLAGLALVPQDLLNAAQVDGAGAWKRLVKVILPLIKPAILVALLFRTLDAFRIFDNIYVLTGGANNTGSVSILGYDNLFKAFNVGLGSAISVLIFLSVAVIAFIYIKIFGAAAPGAEQEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL88</accession>
    <name>A0A132PL88_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17265</name>
        <name evidence="2" type="ORF">AWC31_01830</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23108">
        <property type="protein sequence ID" value="KWX23108"/>
        <property type="gene ID" value="AFM11_17265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13292">
        <property type="protein sequence ID" value="ORX13292"/>
        <property type="gene ID" value="AWC31_01830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.806"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX13292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="134" mass="14551" checksum="14C7BCFE57081E8B" modified="2016-06-08" version="1">MEFITAGADPAEMPFMPAIVTSGGRHIWLSGATAFPLVHKHPHDEDELRVPDGIADQTRACLKNLKIALEAAGGTVTDIVEVTIYNTDMDAQDAVNEAYMEFFGDHRPCRTHIGVNRLVGSQLKIEISAHAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLH6</accession>
    <name>A0A132PLH6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_15345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16405"/>
    <dbReference type="EnsemblBacteria" id="KWX23201">
        <property type="protein sequence ID" value="KWX23201"/>
        <property type="gene ID" value="AFM11_15345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7184"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="36"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="203" mass="22678" checksum="FA877124CD2E792A" modified="2016-06-08" version="1">MVSGHIAWHAVHVAADSAELYPGDIKSVLLSEEQIRTRTAELAEMIAERYRDDLGDDDLLLITVLKGAVMFVTDLARSIPLPTQLEFMAVSSYGSSTSSSGVVRILKDLDRDINDRDVLIVEDIIDSGLTLSWLLRNLATRRPRSLQVCTLLRKPEAVRTDIDVAYVGFDIPNEFVVGYGLDYAERYRDLPYIGTLDPKVYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLK6</accession>
    <name>A0A132PLK6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850256.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16275"/>
    <dbReference type="EnsemblBacteria" id="KWX23228">
        <property type="protein sequence ID" value="KWX23228"/>
        <property type="gene ID" value="AFM11_15510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7217"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="30047" checksum="64187C0FD55CE385" modified="2016-06-08" version="1">MSRTWFITGGTPGNFGVAFAETALDTGDRVTLTSRRPQELATWAEQYGDRVLVVPLELTDPAQVQRAVRTAEEHFGGIDVLVNNAGRGWYGSIEAMDESAMRAMFELNFFAVLSVTRAALPGMRARGNGWIVNVSSVAGLISAPGFGYYSATKYAIEAITDALHDEVAPQGISVLTVEPGAFRTNAYSGFANEPVDERIPDYHDILEEVRAAFVGMDGVQPGDPHRGARAVIAAMAQNPPPRRLILGNSGYDAVIDTLEKNLAAIRANETLSRSADFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLT6</accession>
    <name>A0A132PLT6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoid-associated protein Lsr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15935</name>
        <name evidence="4" type="ORF">AWC31_16510</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850404.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16510"/>
    <dbReference type="EnsemblBacteria" id="KWX23299">
        <property type="protein sequence ID" value="KWX23299"/>
        <property type="gene ID" value="AFM11_15935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18003">
        <property type="protein sequence ID" value="ORX18003"/>
        <property type="gene ID" value="AWC31_16510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7312"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="114" mass="12392" checksum="C5484E7103A9ED07" modified="2016-06-08" version="1">MAKKVTVTLVDDFDGEATADETVEFGLDGVSYEIDLSSKNAAKLRNDLKQWVEAGRRVGGRRRGRAAGTPGRGRGAIDREQSAAIREWARRNGHNVSTRGRIPADVIDAFHAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM55</accession>
    <name>A0A132PM55_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_14165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849734.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09235"/>
    <dbReference type="EnsemblBacteria" id="KWX23431">
        <property type="protein sequence ID" value="KWX23431"/>
        <property type="gene ID" value="AFM11_14165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6939"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="311" mass="34563" checksum="BC9DE92E735C2298" modified="2016-06-08" version="1">MSSLRTHDDTWDIATSVGATAVMVAAARAGETARDDALIKDPYAKILVAGAGTGVWESLLDTEFASKIEDADPEAAAIFEHMGNYQAVRTHFFDDYFAKAVDAGIRQIVILASGLDSRAYRLDWPAGTTVYEIDQPKVLEYKAATLAEHGVQAAAERREVPVDLRFDWPKALRDAGFDDSKPTAWLAEGLLMYLPADAQDRLFELVTELSAPGSRIAAETAGVSSSERREEMRERFQKFADQFNLGSALDIQELIYEDPDRADVADWLNAHGWQAQGQHSLDEMSRLDRLVEMTEEHDRNAFSTFVTAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM86</accession>
    <name>A0A132PM86_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849767.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23448">
        <property type="protein sequence ID" value="KWX23448"/>
        <property type="gene ID" value="AFM11_14265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6961"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="282" mass="28745" checksum="AEE7D6D196850637" modified="2016-06-08" version="1">MSELRVNVPELRAKSSGLEDAANSLPEPPQQFTSAGTDPLSQALTKLTQEKEASFIEALPGTKSDSQKTASDMGVAADWYEKTDQEIHDAIMKRVAEFDAIFGPPDTVGGGGTPASSGGQFGQLVHGETPAGQGAAPPAAVGGQGPVEGGQQGAQSASQIAQQLGQMPMQMMQVPMQMMQQAGQLPQGIMQGVQGGVEQINKLAGEAGKKDAGEKAQPEQQAPAEPEKREETAPPAPAGADDTGANTQNAPVGPPTSGGAPQSAAPVQPSPNRVPSDPSIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMU6</accession>
    <name>A0A132PMU6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848931.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23623">
        <property type="protein sequence ID" value="KWX23623"/>
        <property type="gene ID" value="AFM11_12510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6592"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="190" mass="20588" checksum="B308E353E9B1991A" modified="2016-06-08" version="1">MAKSLLGRGTARTRVLEAALTLFGEHGVSGTTLQMIADSIGVGKASVYYQFHSKEDIVAAAAQPMFDDLARVVAIADAVPDPATRREISITGLIELSVRHRRLAAVLTGDPALESLIQSREDLAETTQRFIDLLLGGAHGHTGRVVISMVTNGIYAAVTDKRLRDVSDEDLLRTLLEVAQQLLRTTSYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN11</accession>
    <name>A0A132PN11_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_13150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03435"/>
    <dbReference type="EnsemblBacteria" id="KWX23728">
        <property type="protein sequence ID" value="KWX23728"/>
        <property type="gene ID" value="AFM11_13150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6723"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="175"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="28882" checksum="BB013868A088BF8E" modified="2016-06-08" version="1">MGAGIAEVSARAGVDVLVFETTDALVTAGRNRITKSLERGVSAGKVTEREKDAALAKLTFTTKVADLADRQLVIEAVIEDEAVKSKIFAELDEVIADPDAVLASNTSSIPIMKLAAATKNPSRVLGLHFFNPVPVLPLVELVTTLVTTDSAAARVEEFASTVLGKQVVRCADRSGFVVNALLVPYLLAAIRMVEGGFATIEDVDKAVVAGLSHPMGPLRLSDLVGLDTLKLIADKMFEEFKEPLYAAPPLLLRMVEAGQLGKKSGQGFYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN36</accession>
    <name>A0A132PN36_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L,D-transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_13070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849207.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03355"/>
    <dbReference type="EnsemblBacteria" id="KWX23713">
        <property type="protein sequence ID" value="KWX23713"/>
        <property type="gene ID" value="AFM11_13070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6707"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453433" evidence="5">
        <location>
            <begin position="44"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="63"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="259"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="443" mass="46575" checksum="968D722E7C2679AF" modified="2016-06-08" version="1">MSPAGDNQASAPLINRRRALTALAVGVGAGALAACAGKTPGQAEPEAAPAAPSLTFEPVADSADVLPTAPVEVKVSDGWFQRISLTNPDGKVVAGKLNQDRTAFSVTEPLGYDSTYTWAGTVVGHDGKSVPVEGKFTTVAPQTQVSGQFQLADGQVVGVAAPVILQFDASIDDEHKAIVEKALKVTTEPSVEGSWAWLPDEVGGSRVHWRSREYFPPGTKVSVKAPLYGVDFGDGAYGAADSTLDFEIGRRQVVKAEASSHRIQVLDGSGAVIMDFPCSYGEGDLDRNVTRSGIHVVTEKYEDFYMTNPAAGYANVRERFAVRISNNGEFIHANPASSGAQGNSNVTNGCINLSIEDAQQYFNTAMYGDPVEVTGTRIQLSYADGDIWDWAVDWDEWTAMSAISDKKPPADIPASAPATPTDAPTLSGTPTTTTPAPSPAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNF8</accession>
    <name>A0A132PNF8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_13200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03485"/>
    <dbReference type="EnsemblBacteria" id="KWX23876">
        <property type="protein sequence ID" value="KWX23876"/>
        <property type="gene ID" value="AFM11_13200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6733"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="112"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="34440" checksum="4D3AD943B7C1C51F" modified="2016-06-08" version="1">MTLTRPDVDRRVRAAVRLLGVRAAIAVPVTVAVSAAMFAVASLSPFDPLVAHLGANYQTATQSQREAVRAAYDIEQPWWQAWIDWMSGVLRGDLGWSSTQSQAVTTVLTERMPFTLALSGLALMTAAISAILLGCIAGMRRGGVLDRLCTGLAVICAAVPPFVISLALVAVVAVGLRWLPASGASDPGDDYTVGGVLTHGVLPLIALTVSQIPWLLLTMRTAVVQACGSDAVRAARARGIHGWALLRGHIAPVSVLPTLALLGTRLPELIAGAAIVETVFGWPGMAAVLVESAAALDFPLLAALTVGSALAVLAGSALSDAAAVALDPRIGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNP8</accession>
    <name>A0A132PNP8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849483.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03960"/>
    <dbReference type="EnsemblBacteria" id="KWX23817">
        <property type="protein sequence ID" value="KWX23817"/>
        <property type="gene ID" value="AFM11_13715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6839"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="26058" checksum="18DDD661BCF83090" modified="2016-06-08" version="1">MSALAALDAERIKLSTTRSPLWSVVGVAVLSFGVAALQGWSAYGYTPLAPGKAALGVAVFGVPVLMVLSSMTVTGEYRTGLIRTTFLATPNRTKVLIAKAVVCAAFSSVCAVVMVLGAVLVARLFAEPVIGAELSPTNPATWSVAGGFALYAALAAVLGVGVGALVRFAAGAVAALLLWPLVAEPLLGNMPNLEAGPWLPFANMFRFLGVEWLFPTYDMPWGEVGSLVYFLAWVAAVFIAAVVVLNRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNV3</accession>
    <name>A0A132PNV3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848347.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30380"/>
    <dbReference type="EnsemblBacteria" id="KWX24011">
        <property type="protein sequence ID" value="KWX24011"/>
        <property type="gene ID" value="AFM11_11645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6406"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021804">
        <property type="entry name" value="DUF3375"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11855">
        <property type="entry name" value="DUF3375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="488" mass="53913" checksum="1208CF8461E35DBE" modified="2016-06-08" version="1">MQHADVGRPSLERLYELNRTVADSRSIRLLVTNNLAGYLTLMERHLDRGAKLTETELVVRLERDLAAMGSDNEQSGLQLIKYWASQGWLHRITEQAGDGERNVCYLTYEARAVLDFARRMRREDTIATGGSIAGVAAGLRRVAGQVSNDPERIRADIEQEIEKLQAELDALDEGRRPEPNPLDVEDEARAIALQMEQIISDIGQYGSMLNRITTRLLDSSADTDLGYRERQRQLFDDYESLFASRESASYTAFTRMVQDPEQRAGLVADIEMVTSQLPHLDPGLREVMTGFFTLVSAQTAEVGRTRQRCARRIKRFVASGTLEESRGVTRQLNDALASAHELLKVSLADSRVGLEVPLARADFNSIGAVAFKIRDAVPPTPAEPSDGEVNLSAFAALAAQVDATELADLVNAAVERGPLPLPAAIGMLDSAYLGHVIVLWSWALKQPHDDGIETVRVRFQSLEGADREIEVPALVFTEPIPIVSESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNW0</accession>
    <name>A0A132PNW0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_11695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848376.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30330"/>
    <dbReference type="EnsemblBacteria" id="KWX24021">
        <property type="protein sequence ID" value="KWX24021"/>
        <property type="gene ID" value="AFM11_11695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6416"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="497" mass="51166" checksum="16ABADFB6D16CDCA" modified="2016-06-08" version="1">MTTSATPESDQLPHRRLPFWVALALSVATVGPTLAMSGNGQGLIGTVGKAIPLVFLIGLIGVSLVGYSFVRLTRHLNHAGSAYALVGGTVGPRAGFFSGFAMLGAYVGFSIGTLALTAAFTNAFIAQLQPASENPYQLPWLVVVVIGAVISFALAGRDIRLLAKILLGIEGIGIVAMVVLVVVIFARGGAETTGIDFSVFSFSGGGVSAAAVLSGVVAAFLSWAGFEACASMGEETDNPGRNIPRALAGTLILTGVLFVVVMFAQVIGFGTDEAGLAAFQSSGNTLGDLGSSYIGQWFSLLIIFTATVAAFGCHMATAATSGRMLYAFGRDGFGPKSLAHIHEATGGPRRASWLVVGLALVINLICGAIGWPDMGTGNDAIDTYFLFAVAGSVCLMVCYLLVEIAAAWFVGAPKFIDVHGGHGKVLGLALPLLGAVVIAVVLWFNVKDAETWTAAPLLGLYWCAIGLVIALAASGIAKRVGESLTAELALTPPVEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP05</accession>
    <name>A0A132PP05_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30275"/>
    <dbReference type="EnsemblBacteria" id="KWX24033">
        <property type="protein sequence ID" value="KWX24033"/>
        <property type="gene ID" value="AFM11_11755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6429"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="29"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="402" mass="43496" checksum="FE8AC5401BD39614" modified="2016-06-08" version="1">MAWVRPPGTLVAVTTGESTVGGTRSFLPAVEGMRACAAMGVVLTHVAFQTGHTGGITGRIFGRFDLAVAVFFALSGFLLWRGHAAAARGLRERPPTGHYLRSRIVRIMPGYLVAVVVILLLLPEAKADLTVWLANLSLTQIYVPLTLTAGLTQMWSLSVEVSFYLALPLLAFFARRLPVRARIGVIVAVAALSLLWVRIPFDGTTGLNPWNWPPAFFSWFAAGMVLAELTVSPFGWVHRLARRRVLMAVIAAVAFGIAASPLAGLEGLHPGSVGQVTLKTAMGAVVAGALLAPLVLDHPDTPHRILGSPVMVTLGRWSYGLFVWHLAALAMVFPMLGEFLFNGRMLVVLVLTTVFGFALAAVSYALVESPCREALRRWEYRHERPVPPLDSSITPEPEPISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP46</accession>
    <name>A0A132PP46_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_12220</name>
        <name evidence="5" type="ORF">AWC31_09755</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848655.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09755"/>
    <dbReference type="EnsemblBacteria" id="KWX24116">
        <property type="protein sequence ID" value="KWX24116"/>
        <property type="gene ID" value="AFM11_12220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09220">
        <property type="protein sequence ID" value="ORX09220"/>
        <property type="gene ID" value="AWC31_09755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6523"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX09220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="99" mass="10650" checksum="2858A08BD46A7BA7" modified="2016-06-08" version="1">MADESVLHGYSPQKENYAKRLRRIEGQVRGIAKMIDEDKYCIDVLTQISAVNSALQSVALGLLDEHLGHCVTQAVAEGGDQADAKLAEASAAIARLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPB3</accession>
    <name>A0A132PPB3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxy-2-methylbutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848726.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09665"/>
    <dbReference type="EnsemblBacteria" id="KWX24133">
        <property type="protein sequence ID" value="KWX24133"/>
        <property type="gene ID" value="AFM11_12315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6542"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="26435" checksum="6F76C930740B6B7A" modified="2016-06-08" version="1">MDINGASAIVTGGASGIGAASARQLAAKGARVVVADLQAEKGEALAKEIGGAFVSVDVTDTAQIEAAVNKATELGPLRALVNSAGIGWAQRTIGKDGEFASAHNLDAYKKVLAINLVGTFDCIRLAATAMSRNEPTDTGERGAIVNMTSVAAFDGQIGQAAYSSSKGGVVGLTLPVARDLSAVGIRVNTVAPGLIDTPIYGEGEASEAFKAKLGESVLFPHRLGKPEELASMVIELITNSYMNAEVVRVDGGIRMPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPK3</accession>
    <name>A0A132PPK3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trans-2-enoyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847253.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05510"/>
    <dbReference type="EnsemblBacteria" id="KWX24261">
        <property type="protein sequence ID" value="KWX24261"/>
        <property type="gene ID" value="AFM11_09715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5981"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="327" mass="34553" checksum="BB322BB39AD931FE" modified="2016-06-08" version="1">MQHLVLTEFGDPQESVHLVDGADPAPGPGDVVVRMEAAAINPSDLLLIEGRYLARPALPATVGAEGVGIVEAAGPCADDALVGRRVVVLPTFKYGTWSQKVVAAQDDVVVVPGDDPVQLAMLSINPVTAHLLLERITTLGIGDWVGQTAANSAVGLHVITLARRRGIKTLNVVRRADAVADVRRAGGDVVLVSGPDLAAEITGALGEEKLRLVLDPLGGPAAAPLTSALDFGGSVVSYGTLTGAPQGLTSADLFQRELRHTGFWLGNWYFRAPTREIRAVLGHLATLMADGLLHVPVEATYRLNDHRKAFEHAQTTQRGGKVLFTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPP4</accession>
    <name>A0A132PPP4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847294.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05435"/>
    <dbReference type="EnsemblBacteria" id="KWX24275">
        <property type="protein sequence ID" value="KWX24275"/>
        <property type="gene ID" value="AFM11_09790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5996"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040577">
        <property type="entry name" value="Gln-synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022147">
        <property type="entry name" value="GSIII_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18318">
        <property type="entry name" value="Gln-synt_C-ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12437">
        <property type="entry name" value="GSIII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="194"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="725" mass="78376" checksum="834AAA6756568E48" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPQ0</accession>
    <name>A0A132PPQ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10055</name>
        <name evidence="4" type="ORF">AWC31_18540</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX16864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847435.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18540"/>
    <dbReference type="EnsemblBacteria" id="KWX24319">
        <property type="protein sequence ID" value="KWX24319"/>
        <property type="gene ID" value="AFM11_10055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16864">
        <property type="protein sequence ID" value="ORX16864"/>
        <property type="gene ID" value="AWC31_18540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6047"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="117"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX16864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="214" mass="23774" checksum="64658D733618CB8C" modified="2016-06-08" version="1">MAHSKKGHSRRTGHLSGPSGPHAPNRPLHSVETFATSNPEASLWGRRRVLLLNSTYEPLTALPLRRAVIMLMCGKADVVHDDPAGPLIHSATRTIVVPSVIRLRTFVRVPYRARIPMTRAALMHRDRFRCAYCGGRADTVDHVVPRSRGGEHSWENCVAACASCNHRKADHLLAELGWTLRAVPMPPKGQHWRLLSTIKELDPAWVRYLGEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ10</accession>
    <name>A0A132PQ10_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847805.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19310"/>
    <dbReference type="EnsemblBacteria" id="KWX24436">
        <property type="protein sequence ID" value="KWX24436"/>
        <property type="gene ID" value="AFM11_10795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6198"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="144" mass="15771" checksum="AD40CFDE111AD756" modified="2016-06-08" version="1">MSTQARTDDLVEIQQVLAKYAVTITQGDIDGLVSVFTPDGTYSAFGETYALERFPVLVDAAPKGLFMTGTSLVTFDPDNPDAASGTQPLCFIEHSAHDMRIGYYNDTYVRTADGWRLKTRAMTFIRRSGAHDHGKPHAIGRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ45</accession>
    <name>A0A132PQ45_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847462.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18590"/>
    <dbReference type="EnsemblBacteria" id="KWX24327">
        <property type="protein sequence ID" value="KWX24327"/>
        <property type="gene ID" value="AFM11_10110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6059"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="3">
        <location>
            <begin position="308"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="516" mass="55924" checksum="85EA6FE2449D04B5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ73</accession>
    <name>A0A132PQ73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847832.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19355"/>
    <dbReference type="EnsemblBacteria" id="KWX24445">
        <property type="protein sequence ID" value="KWX24445"/>
        <property type="gene ID" value="AFM11_10840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6207"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="319" mass="36001" checksum="C53285004FFD341E" modified="2016-06-08" version="1">MTDRPKPEEIILYDKDPKTKIATITFNRPEFLNAPTSMARLRYADVLRAANADNDVKVVIIRGVGDNLGSGADLPEFMEGNDNPAVRLAELRLEDDGVGEVTYPPKGTFRNGATISAWYANSQAGNRALQDFKKISIVEAKGYCYGWHFYQCADADLVISSDDALFGHPSFRYHGWGPRMWTWVQMMGLRKFQEMVFTGRPFTAAEMYDCNFLNKVVPRDQLEAETEKYARACARNRPVDTVFQQKLFFEVFKQHQGEYMGSLLSAFFESMGNGVANDGDDDLDMFEAIDSGLSGAVNDNDSKFPPDFRLSKKNRNKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR15</accession>
    <name>A0A132PR15_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ORF">AFM11_08585</name>
        <name evidence="16" type="ORF">AWC31_13785</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846522.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13785"/>
    <dbReference type="EnsemblBacteria" id="KWX24714">
        <property type="protein sequence ID" value="KWX24714"/>
        <property type="gene ID" value="AFM11_08585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18378">
        <property type="protein sequence ID" value="ORX18378"/>
        <property type="gene ID" value="AWC31_13785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5568"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="64"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="179"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX24714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX18378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="357" mass="37742" checksum="E55180217843CEE2" modified="2016-06-08" version="1">MNERAEQHGISYASAGVDIEAGDRAVELFKPLAAKATRPEVRGGLGGFAGLFALRGGYREPVLASSTDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPERVSAIVSGIAEGCVRAGCALLGGETAEHPGLMEPDHYDISATGVGVVEADDVLGPDRVKPGDVIIAMASSGLHSNGYSLARKVLLEIDRMNLAGHVEEFGRTLGEELLEPTLIYAKDCLALAAETQVRTFCHVTGGGLAGNLERVIPHGLTAELDRGTWTPAPVFQMIAQRGRIERAEMEKTFNMGVGMVAVVAPEDTDRALAILTARHLNCWTLGTVKKGGKDSVRAQLVGQHPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRH8</accession>
    <name>A0A132PRH8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845078.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11585"/>
    <dbReference type="EnsemblBacteria" id="KWX24936">
        <property type="protein sequence ID" value="KWX24936"/>
        <property type="gene ID" value="AFM11_05725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4336"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="122" mass="13766" checksum="C5B640BDA0AC94D6" modified="2016-06-08" version="1">MERDDDANAQLDRAFMALADPVRRSIVARLSRGPATVNELAAPFDITKQAVSKHIQVLEQAGLVTRSRDAQRRPVHLDAAALEGLTAWIDRYRLNAERSYRRLDDLLAQISPKTDTTQEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRY9</accession>
    <name>A0A132PRY9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_06710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845407.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28965"/>
    <dbReference type="EnsemblBacteria" id="KWX25106">
        <property type="protein sequence ID" value="KWX25106"/>
        <property type="gene ID" value="AFM11_06710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4541"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="7">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1183" mass="128959" checksum="3EF118B489DBFA68" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS70</accession>
    <name>A0A132PS70_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_09295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13075"/>
    <dbReference type="EnsemblBacteria" id="KWX24872">
        <property type="protein sequence ID" value="KWX24872"/>
        <property type="gene ID" value="AFM11_09295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5707"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="360" mass="39501" checksum="5CD31488DCEE8BA4" modified="2016-06-08" version="1" fragment="single">APEYRDGDGYRGPSNATEEILAGIYAQVLGLDQVSVDDSFFDLGGNSLSAMRVIAAVNRAFDTRIPVSSMFTSPSVESLSRQLGTRADAAVAPVELLHDGVGTPLICIHDGFGFSWSYRTLANYLDCPIVGINQIESDDEGEPDSVHSMAVQYADRIQAAYPDGPYKLLGWSVGAVIAHEVAIELQRRRCVVDRLVLLDPASTVVKPLLTRRSSLDRRILDELMSNSGIRMSAHSKDIVSRRVADLVGNDENAGLDAPLPLEELVNQMARNIEANRRRLRGYRAGVFNGDIVLFVAGQRVVTDTRWPTSSSRMAVKTQVRRWRRNVTGAIAAYPVKCTHYAMLAADALKHYGEDLKRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS81</accession>
    <name>A0A132PS81_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferritin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_07060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845598.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17655"/>
    <dbReference type="EnsemblBacteria" id="KWX25170">
        <property type="protein sequence ID" value="KWX25170"/>
        <property type="gene ID" value="AFM11_07060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4611"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="18088" checksum="3BDCA8A4F7C6897E" modified="2016-06-08" version="1">MSTRRTESEIQGFQASPDLSRNLQQVLVDLIELALQGKQAHWNVVGTNFRDLHLQLDELVDFAREGADTVAERMRALDAVPDGRSDTVADSTSLPEFPAYERSTDEVVDLVATRVYATIDTMRRVHDDVDAEDPSTADILHQLIDGLEKLAWLVKSENRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS98</accession>
    <name>A0A132PS98_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_06915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845495.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28735"/>
    <dbReference type="EnsemblBacteria" id="KWX25144">
        <property type="protein sequence ID" value="KWX25144"/>
        <property type="gene ID" value="AFM11_06915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4582"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="28496" checksum="3BD8730D6D3F505E" modified="2016-06-08" version="1">MTSVLELDDVTFRRDGKQIIDGISLRVQAGEHWALLGPNGAGKSTLLGFCAAVTFPTTGTVRVLGGQMGRTDLTVLRRSIGHVNPRHRLQYPLSVREVVLTGITATIDTAARWTPTAGQVRRAEELIDTVGLSARVDAVWPTLSQGERGRALIARALISDPQLLLLDEPTTGLDVAAREQLLETLDTLDDTHGDMASILVTHHLEELPTSTTHALLIADGRTVASGPALDTVTTDHVTTAFAHPVTVGHQDGRWTARAKPGPRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSH0</accession>
    <name>A0A132PSH0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_03070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843832.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25289">
        <property type="protein sequence ID" value="KWX25289"/>
        <property type="gene ID" value="AFM11_03070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2483"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="253"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="498" mass="53063" checksum="856AE4DBA6E05ACF" modified="2016-06-08" version="1">MSPDNALGAPLLQVDRVSKSYGATAALSEVSVSFFAGEVHALLGENGAGKSTLMKIIAGVHSADSGTITGARGDDLDVKMVFQELSVVPEMSVRENMEMSQVADRGLVVKHAAMEPKLRAALHAAGLSGLDLDIPVEALPLAQRQLLEIARGLYSEAKVLILDEPTATLSDVEIARVHEVVRSLVRRGHGVVYITHRLGEVFTLSDRITVMRSGKVVASEVTSAFTMDDVVTLMLGHEHAGHSAEPLSGLAPVEERRLLSVDRLSATHQFHDVSFTVRAGEVLTLFGQIGSGADQVIRALAGLSHIDAGTVHIDGDRCAIDSRPASQASGISYVSADRTVEGVFLDCSVAANISSGALKSIVRHGVLSRRREQRLAQNYARLVAFDPSRVDTPVGALSGGNQQKIAIARALATAPKLLVLNEPTRGVDIGARAEIYRVIRNLAHDNVAVVVYSSDIVELRELGDRVITMFRGGIVADRHTAHVEDSRLLSEILHGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSJ3</accession>
    <name>A0A132PSJ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25316">
        <property type="protein sequence ID" value="KWX25316"/>
        <property type="gene ID" value="AFM11_03240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2523"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="86" mass="9161" checksum="ED7E91AF3E17210D" modified="2016-06-08" version="1">MASMAHRLAESRELLQGHGVVALPADRGPVVSAMPTAGPARIRDMFAEVLSADPMMWPRESRCDVGKSPGRDADGKVFQSASQAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSM6</accession>
    <name>A0A132PSM6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_03535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844069.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21615"/>
    <dbReference type="EnsemblBacteria" id="KWX25361">
        <property type="protein sequence ID" value="KWX25361"/>
        <property type="gene ID" value="AFM11_03535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2582"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="23"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="482" mass="50624" checksum="44466F8EA9812409" modified="2016-06-08" version="1">MHIEDLISSVPTGLWIGGEEREASSTFNVLDPSDDQVITAVADATAEDAVAALDAACAVQAEWAATAPRERGEILRAVFEKIKERADDIAALMTLEMGKVLAESKGEVAYGGEFFRWFAEEAVRIGGRYTPAPAGTGRIIVTKQAVGPCYAITPWNFPLAMGTRKMGPAFAAGCTMIVKPAQETPLTMLLLAKLMDEAGLPKGVLSVLPTSNPREVTGALIDDGRLRKLTFTGSTGVGKALVKQSADKLLRTSMELGGNAPFIVFDDADVDAAVDGAILAKMRNGGEACTAANRFHVANAVREEFTEKLVKRMSEFTLGKGIEPSSTLGPLINSKQVATVTELVSDAVSRGATVAVGGVAPGGPGNFYPATVLADVPADARILKEEVFGPVAPITGFDTEDEGVAAANDTEYGLAAYVYTRSLDRALRVAEAIESGMVGINRGVISDPAAPFGGIKESGFGREGGTEGIEEYLDTKYIALTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSV1</accession>
    <name>A0A132PSV1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PknH_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_03625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844111.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25375">
        <property type="protein sequence ID" value="KWX25375"/>
        <property type="gene ID" value="AFM11_03625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2600"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026954">
        <property type="entry name" value="PknH-like_Extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038232">
        <property type="entry name" value="PknH-like_Extracell_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14032">
        <property type="entry name" value="PknH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="PknH_C" evidence="5">
        <location>
            <begin position="61"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="251" mass="26400" checksum="5AC72CB6E6238C57" modified="2016-06-08" version="1">MTQAWYPVPKPPKKSSTGRTVGLVAAALVALIAVVALVIWGVQPRTVDGQAAAVQAGGPVVDDSDLEGLLLSPDEISDIVKLPGMVTVASWMNPDAADDPGSYDPLDCLGAMYSGMSVVYDENGYEAIFQTRTGPSNKKGLPAVDQSVATFESANAAQSALGDYIELWKSCAEKKFTYTGPDARESWTLGTPESNHDGMTTLQNAMDGEQLYLDRAVAARGNVLVEVQLQDAKPAGAVVAIAQGILDRIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSX9</accession>
    <name>A0A132PSX9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844371.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25449">
        <property type="protein sequence ID" value="KWX25449"/>
        <property type="gene ID" value="AFM11_04110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2700"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="176" mass="19321" checksum="C1EA97EF17F58C12" modified="2016-06-08" version="1">MNTGALHRFGERLLDGARAWGSVEIRPGRFGIVQYRLVVYPPGLSRSERRWLRLARGWPVWGFMVWLLCQIVLTGTMTSWAVFGASTAAATGAGVVAFAMAGEARTRVRSMLVTTMLGYPDATAEANRDRLAELAAVLLEADDRLAHGDIGVVEHELIWWQVYDRLADSVAAGPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTD2</accession>
    <name>A0A132PTD2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_04985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844698.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25591">
        <property type="protein sequence ID" value="KWX25591"/>
        <property type="gene ID" value="AFM11_04985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2878"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="348" mass="37195" checksum="766D308B585B40C3" modified="2016-06-08" version="1">MAGGEERRRRAAAATSTATMADVAELAGVSAQTVSRVLRQPHSVSETTRRKVHEAIRASGYVPNRAASHLASNQSHTVAAILPVLSASVFADTMQAASAVLSPAGYQIQLGYTDYRTSTEEDLIRNFLGWRPDGFFIVGALHTPAAAAMLRSADVPIVETWGWSDQPLDLLVGFSNRRAIADLVRALVAKGHEKLAFAGVLTPGDERAAERRAGFTEVVEELFPGQPLRIVNMAEEPVAMRTGRKLLERVVGDHPDVTAAVFSSDIFAAGAVLSAKRLGIDVPADLAITGFGDFEISAMLEPALTTVAIDAEAIGARAAEILLDRMRGEEPPARQLDVGYTIRMRDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTD9</accession>
    <name>A0A132PTD9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_04930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844680.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20225"/>
    <dbReference type="EnsemblBacteria" id="KWX25583">
        <property type="protein sequence ID" value="KWX25583"/>
        <property type="gene ID" value="AFM11_04930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2867"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="63"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="231"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="485"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="574" mass="61707" checksum="388B1B6736441ADF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTM9</accession>
    <name>A0A132PTM9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21355"/>
    <dbReference type="EnsemblBacteria" id="KWX25402">
        <property type="protein sequence ID" value="KWX25402"/>
        <property type="gene ID" value="AFM11_03810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2638"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="586" mass="61657" checksum="70352A5FCE492D7F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTN7</accession>
    <name>A0A132PTN7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Magnesium chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03670</name>
        <name evidence="4" type="ORF">AWC31_21485</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844869.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21485"/>
    <dbReference type="EnsemblBacteria" id="KWX25675">
        <property type="protein sequence ID" value="KWX25675"/>
        <property type="gene ID" value="AFM11_03670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16765">
        <property type="protein sequence ID" value="ORX16765"/>
        <property type="gene ID" value="AWC31_21485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2609"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX16765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="460" mass="49939" checksum="B3C6846F78C96B32" modified="2016-06-08" version="1">MSQPKDLPRTVGELRASGHRERGVKAEIRENLLAALADRRDIWPGILGFDDTVIPQLERALIAGHDVVLLGERGQGKTRLLRALTGLLDEWTPVIAGAELGEHPYSPITPESIRRAADSGEDLPIEWRHRSERYTEKLATPDTSVADLVGDIDPIKVAEGRSLGDPETIAYGLIPRAHRGIVAVNELPDLAERIQVSMLNVMEERDIQVRGYTLRLPLDVLVVASANPEDYTNRGRIITPLKDRFGAEIRTHYPLEIDAEVGVIRQEAHLAAEVPEYLLAILARFARNLRDSNSIDQRSGVSARFAIAAAETVAASARHRSAILGEDDPVARVVDLATVIDVLRGKLEFETGEEGREQAVLEHLLRRATADTAQRLLGGIDVGPVVAAVEEGSPVTTGERVSAKDVLAALPDLPAVDAITTRLNAVSVGQRAAAIELALEALYLAKRIDKVSGEGETVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTW5</accession>
    <name>A0A132PTW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thiol:disulfide interchange protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_00335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842186.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33450"/>
    <dbReference type="EnsemblBacteria" id="KWX25779">
        <property type="protein sequence ID" value="KWX25779"/>
        <property type="gene ID" value="AFM11_00335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.68"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041017">
        <property type="entry name" value="Thioredoxin_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17991">
        <property type="entry name" value="Thioredoxin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="276"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="575" mass="61346" checksum="2B414C3CBFBA6723" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTX2</accession>
    <name>A0A132PTX2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00385</name>
        <name evidence="2" type="ORF">AWC31_33500</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842216.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33500"/>
    <dbReference type="EnsemblBacteria" id="KWX25789">
        <property type="protein sequence ID" value="KWX25789"/>
        <property type="gene ID" value="AFM11_00385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11603">
        <property type="protein sequence ID" value="ORX11603"/>
        <property type="gene ID" value="AWC31_33500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.78"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="239" mass="27392" checksum="F1064C0663B3A022" modified="2016-06-08" version="1">MTQLLGRDEFRAELENAIKGREAKNASFSKAWAEGKLSKQHFARWAENHYHYVGPFADYLANIYSNTPDQFTGAKDFTLQNMYEEELADIRHTDLLIKFGEACGTTRERIEDPSNMNAITRGLQAWCYAVSQREHFVVATAALVVGLESQVPSIYTKQIVPLREVYGFTEDEIEFFDLHITSDVVHGERGYQIVLDHADTPQLQQRCLQLVRWGAEMRFSYTKGLYDYYVAPDLESASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU01</accession>
    <name>A0A132PU01_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844576.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20510"/>
    <dbReference type="EnsemblBacteria" id="KWX25532">
        <property type="protein sequence ID" value="KWX25532"/>
        <property type="gene ID" value="AFM11_04635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2806"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="68"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="163" mass="17511" checksum="8018A5072FFB7843" modified="2016-06-08" version="1">MSSTAGHDGFHPDLTEAAHGHRPQRTRVHHVRAAELSSSTAQTDGMQRFAAISGGSVGSEKIWMGETHVSPATASDNHHHGESETAIFVRSGNPEFVFHDGVQEVRIATAPGDYVFVPPYMPHREENPDPDNPAVVVIARSTQEAIVVNLPALYALSDDPDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU86</accession>
    <name>A0A132PU86_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20135"/>
    <dbReference type="EnsemblBacteria" id="KWX25612">
        <property type="protein sequence ID" value="KWX25612"/>
        <property type="gene ID" value="AFM11_05105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2902"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="461" mass="49526" checksum="81E0DA37B8A42A4F" modified="2016-06-08" version="1">MTNISAAWRLETGIDERRLPVVADVDVAVVGAGAAGVAAATVAAESGATVVIVEKYGFAGGAAVAGMSGTICGMYLASDDGARPEQIIHGFTERFSGELRVRGGLTAPQPYGKTFTAAHDPLVWREAADHLLTSAGVRILFHTQVIDVVADQGTYRGLVIASNAGVGIIRAARVIDASGDGAVVARGGGAYRFGADGRIQNPTMFFRLGNVDCAAFWAAWGPNTISPQWVSDAIGRARQAGMDLPRNKIWIFDTTRRNELLVNATRLTAPDGRMLNVIDPEDFTIAEIEGRRQVREYARFLAESVPGCAQAFVVDTGVEAGIRQTRTIDGITTLSDDDVVNGVKRHDSICRSPWPIELHDGEKPKLHWLLDDYYDVPYATLVPERGENIIVAGRCLSAEHQALASARVTAQCFEYGHAAAVATLLSLDRDTAYRDLAPRDIQARMIANGSALQTPERQEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUH4</accession>
    <name>A0A132PUH4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842882.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25998">
        <property type="protein sequence ID" value="KWX25998"/>
        <property type="gene ID" value="AFM11_01700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.350"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="27897" checksum="9401E6AE56648C8B" modified="2016-06-08" version="1">MPEDRSHTVSALLAAYDTRVPIDPLSEHDPEFTVEKAYELQLQQVSAWTAMGRVIKGHKVGLTSSAMQRQLGVDQPDYGHLFADMFHLESVPIDTRSFISPKAEPEIAFVLDRDLSGPGVTTVDALRAVGYVLPALEIIDSRIRDWRITLPDTIADNASSGGVVLGSTPVALRGRDLRLTGCVLSTNGEVAYTGAGAAVLGSPINALVWLANTLGALGVTLEAGSVVLPGSLTAALPVTAGTTVTACFTGIGSVTACFAQVGEARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUY1</accession>
    <name>A0A132PUY1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">General stress protein CsbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_02480</name>
        <name evidence="5" type="ORF">AWC31_35260</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843285.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35260"/>
    <dbReference type="EnsemblBacteria" id="KWX26123">
        <property type="protein sequence ID" value="KWX26123"/>
        <property type="gene ID" value="AFM11_02480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11901">
        <property type="protein sequence ID" value="ORX11901"/>
        <property type="gene ID" value="AWC31_35260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.508"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX11901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="80" mass="8408" checksum="3FBFD7F23E925E67" modified="2016-06-08" version="1">MTEKNSGPEEGIKGAVEDVKGKAKEAVGTVTGRDDLVREGKAQQDKADAQQDAAKKEAEAESARAGAKAAEKREQASQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV13</accession>
    <name>A0A132PV13_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ORF">AFM11_02945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35725"/>
    <dbReference type="EnsemblBacteria" id="KWX26198">
        <property type="protein sequence ID" value="KWX26198"/>
        <property type="gene ID" value="AFM11_02945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.607"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX26198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="173" mass="17587" checksum="4ED794373A8592C3" modified="2016-06-08" version="1">MNMASNAAARVGLIMGSDSDWSVMSDAAEALAEFAVPFEVGVISAHRTPGRMLDYAKTAADRGIEVIIAGAGGAAHLPGMVASATPLPVIGVPVPLARLDGMDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRILGSADAGLRARMVKFQADLEAMVLAKDAALRDRLLGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV14</accession>
    <name>A0A132PV14_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02705</name>
        <name evidence="2" type="ORF">AWC31_35480</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843402.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35480"/>
    <dbReference type="EnsemblBacteria" id="KWX26160">
        <property type="protein sequence ID" value="KWX26160"/>
        <property type="gene ID" value="AFM11_02705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11939">
        <property type="protein sequence ID" value="ORX11939"/>
        <property type="gene ID" value="AWC31_35480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.555"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="118" mass="12853" checksum="25459E747A94F486" modified="2016-06-08" version="1">MEPVEINAGSWYLRALRDDDLIDDRPALADLGETDPDYVTRREAQWASDTYYSWAVCEPTTGELLAEVTLDPVAATLHSRARAGHADAAAIAEVSVRRFAGAMLGLTVRDDTDTAVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV18</accession>
    <name>A0A132PV18_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26176">
        <property type="protein sequence ID" value="KWX26176"/>
        <property type="gene ID" value="AFM11_02810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.578"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453363" evidence="1">
        <location>
            <begin position="31"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="525" mass="55410" checksum="6E6AFF61C465F703" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVA8</accession>
    <name>A0A132PVA8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843676.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26266">
        <property type="protein sequence ID" value="KWX26266"/>
        <property type="gene ID" value="AFM11_01795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.369"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="580" mass="61813" checksum="C7E890F96EF1230E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVB3</accession>
    <name>A0A132PVB3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842790.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34440"/>
    <dbReference type="EnsemblBacteria" id="KWX25972">
        <property type="protein sequence ID" value="KWX25972"/>
        <property type="gene ID" value="AFM11_01470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.301"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="26960" checksum="2797E2C456B867E9" modified="2016-06-08" version="1">MTQTTHIGMLTGKIAFISGAGRGIGAAAARLFAREGATVLLAARTERELKAVTDEIRDTGGTADYVVCDLTDGASVRGAVQRTVELWGRLDIAFNNGATIQPPGPLDEVAEADFDHVYAVNLKGVWQAMAAEVAAIRATAKTGAIVNTSSVGSLHSNPELPAYGAMKRAVNSLTESAAATYGSEGIRVNAIAPGPTLTEMIQQWEDVSPGVIERIVAETPLGRAARPDEVAEAAAWLLSDRASYVTGVTLRVDGGTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVB5</accession>
    <name>A0A132PVB5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_02260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843727.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35040"/>
    <dbReference type="EnsemblBacteria" id="KWX26281">
        <property type="protein sequence ID" value="KWX26281"/>
        <property type="gene ID" value="AFM11_02260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.462"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="83"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="232"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="341"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX26281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="601" mass="66667" checksum="EFB3E24860343E21" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVF6</accession>
    <name>A0A132PVF6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cation transport regulator ChaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843766.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35455"/>
    <dbReference type="EnsemblBacteria" id="KWX26295">
        <property type="protein sequence ID" value="KWX26295"/>
        <property type="gene ID" value="AFM11_02680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.550"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009317">
        <property type="entry name" value="ChaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037205">
        <property type="entry name" value="ChaB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06150">
        <property type="entry name" value="ChaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140376">
        <property type="entry name" value="SSF140376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho_N" evidence="2">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="139" mass="15085" checksum="A5AB75B026B0CB95" modified="2016-06-08" version="1">MPKTTKQGKAKKDALPSTLQKSEAKAQRTFAKAHDSAVESYGEGQRAHRVAYSALKHSYEKVGDHWEAKDHRGPSDARARSGGPNASGKSAEGVDASASKKHLMDLARRLDIKGRSTMSKSDLVGAIEKANRRETRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAR2</accession>
    <name>A0A132PAR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000059">
        <property type="protein sequence ID" value="KWX19420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19420">
        <property type="protein sequence ID" value="KWX19420"/>
        <property type="gene ID" value="AFM11_35970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6273"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="120"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="284" mass="32040" checksum="9B6C8B694BFD4B89" modified="2016-06-08" version="1">MKAAAVAALKADHPLPVLLEVAQLARSTFYYHQAKPQVCDPWADLKTAIVEAFEAAGGRYGHRRIHAVVSGRGFVVAKKTVLALMRELALICRVRRRRRYNSYTGAAGQIAENLLNRDFSASAPNQKWVTDVTEFRIADRKVYLSPVLDLFDRSVVAYAWSMSPNVELTNTSLTAAIATLQPGECPLVHSDQGFQYRHWSWRKLLGDAEALQSMSRKGNCYDNAVMENFFGHLKSEMFHHNRFDTVEDFATALDTYIHWYNTERISTKLKGLSPVQYRAQALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAU0</accession>
    <name>A0A132PAU0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000052">
        <property type="protein sequence ID" value="KWX19440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22485"/>
    <dbReference type="EnsemblBacteria" id="KWX19440">
        <property type="protein sequence ID" value="KWX19440"/>
        <property type="gene ID" value="AFM11_35865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6252"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="294" mass="32216" checksum="6C7F781B2DACF2D7" modified="2016-06-08" version="1">MTVPAQSKAIPITVDQIVEEGVKAAEAGASVLHVHVREEATGRPVADLDLFERALTELKKNTDAVIQPTTGGGRGMTVEERASVLKFRPEMATFNAGSFNFGLFPVASRDLPFADWEREYLEGTTGYIFKNTFADMTYMAEQMRQAQTRPEIEVYDVGHIYNLEQLVKDGVLEPPFNLQFVLGVLGANAAEPDQLIHMLRTAERVFGRDSFTWSAAGVGYRGEFSLAALSLTLGGNVRVGLEDNLRVTRTENASSNAQLVQKVAQLAALFDRTPATPDEARQYLDLKGAEAVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB99</accession>
    <name>A0A132PB99_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-phenylpropionate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000043">
        <property type="protein sequence ID" value="KWX19527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19527">
        <property type="protein sequence ID" value="KWX19527"/>
        <property type="gene ID" value="AFM11_35340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5799"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00667">
        <property type="entry name" value="ring_hydroxylating_dioxygenases_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000391">
        <property type="entry name" value="Rng_hydr_dOase-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41534">
        <property type="entry name" value="PTHR41534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00866">
        <property type="entry name" value="Ring_hydroxyl_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="22759" checksum="957E50D18A8731E7" modified="2016-06-08" version="1">MGIEAVTERSNKSLSEQSVLGGHAPRTQRTGDSLPFNDELHLQAHKWLVDESYLLDAQEYDEWLSRLTDDVHYLMPVRVTTALGAGYSTSPGMAHMDENKYSLSRRAARFATEHAWTEDPPSRLRHYVTNVRTFRTGNPDEIIVDSAVLLFRSRGDVREAATVSAGREDLLRRTGSGWQLARRTIMVDEAVIRMQNLAIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBA6</accession>
    <name>A0A132PBA6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859570.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19596">
        <property type="protein sequence ID" value="KWX19596"/>
        <property type="gene ID" value="AFM11_34955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5720"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="84" mass="8114" checksum="4BF182EE28DC0310" modified="2016-06-08" version="1">MNSAKNRRKLKVASAGVGAAAGLAMAVVGVGLSGGLAGAQNEVEPPALTTGETVTETVPPTSPETSVATPSVSATTPSGFAEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBG6</accession>
    <name>A0A132PBG6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal biosynthesis lyase PdxS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_34890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11030"/>
    <dbReference type="EnsemblBacteria" id="KWX19644">
        <property type="protein sequence ID" value="KWX19644"/>
        <property type="gene ID" value="AFM11_34890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="62" mass="6459" checksum="AEE2794F88795DEA" modified="2016-06-08" version="1" fragment="single">MKRGMAEMLKGGVIMDVVTAEQARIAEGAGAVAVMALERVPADIRAQGGVSRMSDPDMIEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBL9</accession>
    <name>A0A132PBL9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859433.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19694">
        <property type="protein sequence ID" value="KWX19694"/>
        <property type="gene ID" value="AFM11_34615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5270"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009822">
        <property type="entry name" value="YaeQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038590">
        <property type="entry name" value="YaeQ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38784">
        <property type="entry name" value="PTHR38784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07152">
        <property type="entry name" value="YaeQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011484">
        <property type="entry name" value="YaeQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01322">
        <property type="entry name" value="YaeQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="183" mass="19726" checksum="0AD85BF17ACDAA8A" modified="2016-06-08" version="1">MAISATIFKVELGVSDIDHGYYADHSLTVARHPSETDERMVVRLLAFGLRAQRLNDVDGELAFGAGLSTPGVPDLRLADYTGRILEWINVGQPDERVLGKAASQADQVLLFPFAAGVATWWRTVGPKVAGLPNLSVVQIPHAPVQQLALSVDRRVSAQVMVIEGQVTMTLGGVDVTFTPEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBQ1</accession>
    <name>A0A132PBQ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_34380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11290"/>
    <dbReference type="EnsemblBacteria" id="KWX19748">
        <property type="protein sequence ID" value="KWX19748"/>
        <property type="gene ID" value="AFM11_34380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5220"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="22"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="326" mass="33968" checksum="C4DB0303ED7BD1B6" modified="2016-06-08" version="1">MPDTRLDLARIQAARTMIDPVFLDTPLYRCEALEPALGCAVSIKLETANPVRSFKGRGTEVVARLLADAGSRAVVCASAGNLGQALAWSGRGLDVTVAASRFAPAVKLDRIRALGATLHLVDGDHEMARDRAAAIANHDGIRLLEDSLDIETCEGAATIGLELIDAAPSFDAVLIALGGGALATGVGHVLKTCTPDVDVICVQPLGAPAMTRSWHERRVVTTESTDTIADGVAGRRPIPAVLDDLLQVADDAVLVRESSIIAGMRMLLDHAGLVVEPSGALGIAAVLENPDRFAGSHVATIVCGSNVDAAAYHRWVSASPSASREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBT1</accession>
    <name>A0A132PBT1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859094.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02605"/>
    <dbReference type="EnsemblBacteria" id="KWX19793">
        <property type="protein sequence ID" value="KWX19793"/>
        <property type="gene ID" value="AFM11_34155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5168"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="67"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="544" mass="58482" checksum="40FF7CB3A1537601" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCE7</accession>
    <name>A0A132PCE7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A dehydrogenase</fullName>
            <ecNumber evidence="6">1.3.8.7</ecNumber>
            <ecNumber evidence="7">1.3.8.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFM11_32850</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:17721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83721"/>
            <dbReference type="ChEBI" id="CHEBI:83727"/>
            <dbReference type="EC" id="1.3.8.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:14477"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83723"/>
            <dbReference type="ChEBI" id="CHEBI:83726"/>
            <dbReference type="EC" id="1.3.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="6"/>
    <dbReference type="EC" id="1.3.8.8" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858327.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32225"/>
    <dbReference type="EnsemblBacteria" id="KWX19999">
        <property type="protein sequence ID" value="KWX19999"/>
        <property type="gene ID" value="AFM11_32850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4899"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004466">
        <property type="term" value="F:long-chain-acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015396">
        <property type="entry name" value="DUF1974"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09317">
        <property type="entry name" value="DUF1974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0274">FAD</keyword>
    <keyword evidence="9 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="14">
        <location>
            <begin position="56"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="13">
        <location>
            <begin position="167"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="12">
        <location>
            <begin position="275"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1974" evidence="15">
        <location>
            <begin position="488"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KWX19999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="630" mass="69155" checksum="E0124B80F2D92EE7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCH9</accession>
    <name>A0A132PCH9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhamnose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858340.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32320"/>
    <dbReference type="EnsemblBacteria" id="KWX20004">
        <property type="protein sequence ID" value="KWX20004"/>
        <property type="gene ID" value="AFM11_32875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4904"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008740">
        <property type="term" value="F:L-rhamnose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019299">
        <property type="term" value="P:rhamnose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013457">
        <property type="entry name" value="Rhamnose_iso-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009308">
        <property type="entry name" value="Rhamnose_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06134">
        <property type="entry name" value="RhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02635">
        <property type="entry name" value="RhaI_grampos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="387" mass="41968" checksum="2E4181A3B1C2DCC2" modified="2016-06-08" version="1">MSAISLHPALDNLAIELPSWAFGNSGTRFKVFGTPGTPRTIQEKIADAATVHRLTGLAPSVALHIPWDTVDDYAALAAYAAEQGVVLGTINSNTFQDDDYKFGSLTHTDKAVRQKAIDHHLACIEIMNHTGSRDLKIWLADGTNYPGQGDIRGRQDRLAESLASIYQHIGPDQRMVLEYKFFEPAMYMTDVPDWGTSYTQVSALGERAMVCLDTGHHAPGTNIEFIVAQLLRLGKLGSFDFNSRFYADDDLIVGAADPFQLFRIMFEVIRGGGLDAASGVALMLDQCHNVEAKIPGQIRSVLNVQEMTARALLVDTEALAAAQEAGDVLGANGIFMDAFYTDVRPALAQWRTDRGLPGDPMAAFAASGYQNTINAERVGGTQSSWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCW1</accession>
    <name>A0A132PCW1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857808.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31950"/>
    <dbReference type="EnsemblBacteria" id="KWX20156">
        <property type="protein sequence ID" value="KWX20156"/>
        <property type="gene ID" value="AFM11_31945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4715"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="69"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="282" mass="31230" checksum="4B97EB6F99968C6E" modified="2016-06-08" version="1">MGELDSTGAAIASNRQNWDDRAEVHVRSKFYDVDGFLADPTDISSVVRNDLSVLTPHLPAAGVQGRSLLHLQCHIGTDTVSWARLGAVDVHGLDLSPNSLRHAERIARADNRDITWIEGDARFASSLIDRRFDTIVTSAGTIVWLPELRNWARSIHDLLEPGGLFMIRDDHPILGAMEYGLWEIADDYLSGGGPRTYEDAGTYTEDSDGQIAHRTNHEWRHDLGEIVGALLAAGLRIEALEELPYMDWPAFPILQPSPQGWELPSGTPRIPLNFAVVAKRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDD3</accession>
    <name>A0A132PDD3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857125.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26500"/>
    <dbReference type="EnsemblBacteria" id="KWX20339">
        <property type="protein sequence ID" value="KWX20339"/>
        <property type="gene ID" value="AFM11_30780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4057"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="116" mass="12237" checksum="CD508AF6E42C20CD" modified="2016-06-08" version="1">MRCLIVDDSAQFRAAASAMLECAGITVDVASDGAEAVRCYHAHPPDVTLVDVDLGVESGFDVAEQLHRIEPPGAPVILISTHDEQDLADMIAASCAVGFLPKIALSPDAIHRMIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDE1</accession>
    <name>A0A132PDE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_30900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857181.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26620"/>
    <dbReference type="EnsemblBacteria" id="KWX20361">
        <property type="protein sequence ID" value="KWX20361"/>
        <property type="gene ID" value="AFM11_30900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4082"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="186"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="353" mass="38434" checksum="877286F9202779AD" modified="2016-06-08" version="1">MTTREFAVPVIDIAPYLRGGDATSDTECARVAREFDAACREPGFMQVVGHGLDPETLTGLTAALDEFFALPLDVKKRYRRDPAANRGYSPPKSESLSMSLGIAAANKMNDYYEAYTVGTEASSFPDHNLPENGYAANNWPEAAPGFQPGVMQYFTRAQDLARILMRVVTDALGLSKGYFDPMIDHSIEVLKMNNFALPEGDTEFAGDLTGMGAHSDFGILTVLWADQVPGLQVLDRDGGWHDVMPADGALLINLGDAMARWTNDRWMSTIHRVDPPVRDGRIQRRRSAAFFFDGNYDAVLEALPGTLAPGEVGYEPITVAENIAMKVAGLRTGVAPEASLREAARVAAASDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDF8</accession>
    <name>A0A132PDF8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857144.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20346">
        <property type="protein sequence ID" value="KWX20346"/>
        <property type="gene ID" value="AFM11_30815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4064"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019919">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03617">
        <property type="entry name" value="F420_MSMEG_2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="37796" checksum="E0603D88F4D2AE0D" modified="2016-06-08" version="1">MGDGTASGLKIDRGVPSDLGRVPEVAAALERQGYDGCWTGELSHDPFLPLLLAAEHTRRLEIGTSIAVAFARSPMTVANLGWDLQAYSQGRFILGLGSQIQPHIEKRFSMPWSHPVRRMREYILALLAIWDCWHDGTPLRFAGEFYTHTLMTPMFTPETNPYGVPKVFVAAVGEAMTEMCGEVADGLLAHAFTTRRYLDEVTIPALERGIKNAGRARDDVAVSCPVFVVTGEDESQMRVAAVPVRKQIAFYASTPAYRKVLELHGWGELQTELHRLSKAGEWDVMGTLIDDDVLEAFAVVAPVDTLAAALHRRCAGAIDRVLPSFPAAVPQSTVTAVLQELRSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDH8</accession>
    <name>A0A132PDH8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857342.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26900"/>
    <dbReference type="EnsemblBacteria" id="KWX20411">
        <property type="protein sequence ID" value="KWX20411"/>
        <property type="gene ID" value="AFM11_31190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4143"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="216" mass="23659" checksum="76A32F9F9488A74D" modified="2016-06-08" version="1">MELGEVVRARRSIRRFLPDRPVPRELVEEALALAMRAPSNSNVQPWRVFFAAGARRDRLVKALSAEVRARRPQSLGLPASFNHLRAELGALVYGSMGIARADAAARWQAQLRNWEFFGAPLAGAVCMHRDLGPADAIGVGMFLQTFLLALTERGIGSCVQVSIAMCPDVLHDVLEIPDELTVLCGVSIGYPDPDFAANHLDIPRNPVEANVVFHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDJ9</accession>
    <name>A0A132PDJ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31135</name>
        <name evidence="2" type="ORF">AWC31_26845</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857302.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26845"/>
    <dbReference type="EnsemblBacteria" id="KWX20400">
        <property type="protein sequence ID" value="KWX20400"/>
        <property type="gene ID" value="AFM11_31135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14778">
        <property type="protein sequence ID" value="ORX14778"/>
        <property type="gene ID" value="AWC31_26845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4131"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX14778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="246" mass="27478" checksum="C141F95434FD702E" modified="2016-06-08" version="1">MTTMWGAPIHKRWRGSRLRDPRQADFLTMASLKWVIANRAFTPWYLVRYWRLLKFKLANPHIITRGMVFLGKGVEIQCTPELAQMEIGRWVHIGDKNTIRCHEGSLRIGDKVVLGRDNVINTYLDIELGDSALMADWCYVCDFDHKMDDINVPIKDQGIVKSPVRIGPDTWIAAKVTVLRGTTVGRGCVLGAHAVVKGDIPDHSIAVGSPAKVVKNRKLAWETSAAQRAELAAALADIERKKAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDR3</accession>
    <name>A0A132PDR3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgB</name>
        <name evidence="12" type="ORF">AFM11_32630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858179.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19765"/>
    <dbReference type="EnsemblBacteria" id="KWX20102">
        <property type="protein sequence ID" value="KWX20102"/>
        <property type="gene ID" value="AFM11_32630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4854"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="260"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX20102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="735" mass="82442" checksum="6C853E32E5EB7E05" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE82</accession>
    <name>A0A132PE82_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857605.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26240"/>
    <dbReference type="EnsemblBacteria" id="KWX20282">
        <property type="protein sequence ID" value="KWX20282"/>
        <property type="gene ID" value="AFM11_31625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4229"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="273" mass="28769" checksum="9A49F788FA7DD54C" modified="2016-06-08" version="1">MTERLTGKVAFITGAARGQGRAHAVRMAKEGADIIAVDIAGPLPPSVPYDSATPEDLAETVRLVEATGRRILAAAADTRDLEALRAVVDKGVAEFGRLDIIVANAGITVPEAWNETTPESFRDVIDINLTGTWNTVMAGAQHIIDGGRGGSIILISSAAGIKMQPFMVHYTASKHGVTGLARAFAAELGKHKIRVNSLHPGAVNTPMGTGDMMAALNRANETNPGLMNMVTPFLPDFIAEPEDIADAAVWLASDESRFVTASRVAVDLGSTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEZ5</accession>
    <name>A0A132PEZ5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cynS</name>
        <name evidence="5" type="ORF">AFM11_27850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855730.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10370"/>
    <dbReference type="EnsemblBacteria" id="KWX20905">
        <property type="protein sequence ID" value="KWX20905"/>
        <property type="gene ID" value="AFM11_27850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3444"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009439">
        <property type="term" value="P:cyanate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="PTHR34186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="SSF55234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate_lyase" evidence="4">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="151" mass="16414" checksum="CE6CE994EE224686" modified="2016-06-08" version="1">MTRDEITAEIVAARLLKGLTWQELADAIDKPVVWTVAALLGQHPVPAECGKVIVDMLGLDESAIPILAAVPMRGGLPTAVPTDPTIYRFYEALQVYGGAVKELIHEQFGDGIMSAINFSLDVQRKPHPAGDRVVVTFDGKFLPYDWTAAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEZ8</accession>
    <name>A0A132PEZ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uracil phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855763.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10445"/>
    <dbReference type="EnsemblBacteria" id="KWX20918">
        <property type="protein sequence ID" value="KWX20918"/>
        <property type="gene ID" value="AFM11_27925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3459"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="entry name" value="PTHR31687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="406" mass="43390" checksum="F129F5338912EFAE" modified="2016-06-08" version="1">MTTIDTEAAAAVDTLHTTAAIRERAQFLLQRARAGESTWFHVDDDALPVAAGEVATLTRDRYPDLDIPYHSRWRHLEAGGIDRKAEIDWASTGSDAASRARSMIDLTVVSVLLDAGAGPDWQYAEPGTGLRFGRSEGLGVASWHAFCGGLFSSDPAQPLQVDATGLRALDAGRLADAFQVRADNPVVGLDGRLQLLHRLADALVAQPEVFGVPGRPGGLFDVLAGPSVAAHDILTRLLTSLSGIWPADNTIDGRPLGDCWRHPAVPGPGLSEGWMPFHKLSQWLTYSLLEPFEWAGVAVTDLGALTGLPEYRNGGLLLDSGVLQLRDPTLASQTWAVGDELVVEWRALTVALLDELADLVCERLGAPQLPLACVLEGGTWATGRALAQRLRAGRPPLSIVSDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF89</accession>
    <name>A0A132PF89_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27995</name>
        <name evidence="4" type="ORF">AWC31_10515</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX09061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855791.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10515"/>
    <dbReference type="EnsemblBacteria" id="KWX20991">
        <property type="protein sequence ID" value="KWX20991"/>
        <property type="gene ID" value="AFM11_27995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09061">
        <property type="protein sequence ID" value="ORX09061"/>
        <property type="gene ID" value="AWC31_10515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3473"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="219"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="323" mass="34391" checksum="B7ADA8805552C723" modified="2016-06-08" version="1">MVEGRRPRVTVIVVFDGVKLLDATGPAEVFAEANQFGADYLLKIASVDGRDVTTSIGTTFPATEKISSIDHADTVLVAGGDNLVGLPIDPALVAAVRDLPGRTRRLASICTGSFILAKAGLLDGRRATTHWRHAGLLGRAYPEIDVEPDAIFVRDGDVYTSAGVSAGIDLALALVEMDYGSDLVRDVARSLVVYLKRAGGQSQFSTLVEADAPPQSVLRRVTDAIAADPAADHSVRSLAKLASVSTRQLTRLFHTELGTTPARYVEMVRIDVARAALDAGRPVGDTARLAGFGSAETLRRVFVSHLGVSPKAYRDRFRTTARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFE2</accession>
    <name>A0A132PFE2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_27030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855268.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06880"/>
    <dbReference type="EnsemblBacteria" id="KWX21041">
        <property type="protein sequence ID" value="KWX21041"/>
        <property type="gene ID" value="AFM11_27030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3279"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="163" mass="17859" checksum="033B360BD9E6C0E3" modified="2016-06-08" version="1">MKAPFERIVSRHGATVLRVCTFVLGRIDAEDAWSETFLAALRAYPELSDDANVEAWLVTIAHRKSVDIIRRRQRDAIAVSELPDRPSPIGVPGEADDELTEAVKTLPPKQRQAVAYHYLVGLPYAEIAEIIGGSTAAARKAASDGIATLRTKYPDALTKGEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFJ6</accession>
    <name>A0A132PFJ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved lipoprotein LppM</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">LppM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27430</name>
        <name evidence="4" type="ORF">AWC31_07365</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855468.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07365"/>
    <dbReference type="EnsemblBacteria" id="KWX21105">
        <property type="protein sequence ID" value="KWX21105"/>
        <property type="gene ID" value="AFM11_27430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10003">
        <property type="protein sequence ID" value="ORX10003"/>
        <property type="gene ID" value="AWC31_07365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3360"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453048" evidence="2">
        <location>
            <begin position="39"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX10003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="234" mass="25260" checksum="F1ED14CF2003521E" modified="2016-06-08" version="1">MTRVRVRRPSHRSRRRLLALVMLLLLLPMAVGCVRVRASITVSPDDRVSGQIIAAAKPRDADDKGPQLLNNLPFATKVAVSEYSRDDYVGSQAVFSDLTFAELPQLAGMNRDAAGVDISLRRAGDLVILEGRVDLTSMNDPEADVLLTVSFPGEVTSTNGDQVSSSIVEWKLRPGVVSTMNAQARYTDPSARSFTTAAIWLIVGAMLVAGVVGWLAWASRDRSPKPGDPVSTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFM1</accession>
    <name>A0A132PFM1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="11">NN:DBI PRT</shortName>
            <ecNumber evidence="5 11">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobT</name>
        <name evidence="12" type="ORF">AFM11_27250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the CobT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="5 11"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855369.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07185"/>
    <dbReference type="EnsemblBacteria" id="KWX21074">
        <property type="protein sequence ID" value="KWX21074"/>
        <property type="gene ID" value="AFM11_27250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3325"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 12" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX21074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="351" mass="35580" checksum="CCB05A905AC5F9B6" modified="2016-06-08" version="1">MTEPAFDPVTPPDADAAAAAADRQVRLTKPAGSLGRLEELSIWAAACQGVCPPRQLTRPRVVVFAGDHGVTASGVSAYPAEVTNQMVANFDAGGAAINVLADIAGATVRVADISVDCVEPLSPAIGAHKIRRSAGNIAVEDALSPADAIAAVAAGRQIADEEVDAGADLLIAGDMGIGNTTAATTLVAALTGAEPVAVVGRGTGIDDYGWMRKTSAVRDALYRARGVVGDPIGLLRVCGGADLAAMAGFCAQAAVRRTPVLLDGLVVTAAALVADRLAPGARAWWQAGHRSTEPAHTLALTHLELDPIVDLRMRLGEGTGAAVALPIVRAAIATLASMATFDSAGILDKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFM5</accession>
    <name>A0A132PFM5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28490</name>
        <name evidence="2" type="ORF">AWC31_32750</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20782">
        <property type="protein sequence ID" value="KWX20782"/>
        <property type="gene ID" value="AFM11_28490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11474">
        <property type="protein sequence ID" value="ORX11474"/>
        <property type="gene ID" value="AWC31_32750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="69" mass="7188" checksum="9B55803C930E3CC8" modified="2016-06-08" version="1">MLQAVETMAAADTRVDEVRLVTFGQALHDGECAQIATLAVTPDCCAGIAARLKTLTSNVRQRCPLGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFN3</accession>
    <name>A0A132PFN3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26195</name>
        <name evidence="3" type="ORF">AWC31_23405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854789.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23405"/>
    <dbReference type="EnsemblBacteria" id="KWX21156">
        <property type="protein sequence ID" value="KWX21156"/>
        <property type="gene ID" value="AFM11_26195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15521">
        <property type="protein sequence ID" value="ORX15521"/>
        <property type="gene ID" value="AWC31_23405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3105"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019967">
        <property type="entry name" value="F420-dep_enz_PPOX_Rv0121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03668">
        <property type="entry name" value="Rv0121_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="139" mass="15479" checksum="B350FE4AFA016BBB" modified="2016-06-08" version="1">MPGFDAVTEFASAPTAVLATLGSDGAPHLVPVVFAVRRDAESATIYTAVDAKRKSTHKLRRLANIERDERVSLLADHYTDDWTQLWWVRADGLAATHYSGEEMATGYALLRAKYRQYERIALDGPVVTIAVTRWSSWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFR8</accession>
    <name>A0A132PFR8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21199">
        <property type="protein sequence ID" value="KWX21199"/>
        <property type="gene ID" value="AFM11_26455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3160"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="459" mass="49505" checksum="B3995EB2346A2132" modified="2016-06-08" version="1">MRRMTNLPERVSRRRRWPLLVSALIAVLIIAISGVAGWWFLGGSEAWARSRWQPPEQTLLSSVRTQPVAGWRTDIAALGLPPESRITTGDTPWVPGPVIQTATARAYLLANSQDPSPQWWLTGFDSTDGRRLFAPVALNATAAAPSCFINGAAVVCISDESGRATAWVIDGQTGNLLHTGPTELRLVTGGKLIATQAGGYLVAAAKDEGLYGVGSQAETTWFVPGRGILGEHNENVAFQGAGAEESGITTMFSLEDGAIIDPQLGEGNRFRNIHFIDGGFAATVEQDYFGPAFARFFDLNGRLTSDKRIKTTFVNTTANLTGIAEDDTFGVYDPHGTKLLNIDDGRSHGIHLIGDTLWVSESDVTQSTVYRPYDMRTGDKGEPCEFDLGVGYLGSDGVVAVRAPVNLKSDLLADAYDLTTCERVWSIPRNGPFGRVTRVGDTLVRVSDDGTEIFSLVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFS9</accession>
    <name>A0A132PFS9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate synthase</fullName>
            <ecNumber evidence="6">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gltD</name>
        <name evidence="6" type="ORF">AFM11_26450</name>
        <name evidence="7" type="ORF">AWC31_22865</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854927.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22865"/>
    <dbReference type="EnsemblBacteria" id="KWX21198">
        <property type="protein sequence ID" value="KWX21198"/>
        <property type="gene ID" value="AFM11_26450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15431">
        <property type="protein sequence ID" value="ORX15431"/>
        <property type="gene ID" value="AWC31_22865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3159"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX15431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="488" mass="53177" checksum="D02A75D3F393E8EA" modified="2016-06-08" version="1">MADPRGFLKHTSRELPSRRPVPLRLKDWNEVYEDFSHGVLQDQASRCMDCGIPFCHNGCPLGNLIPEWNDLVYRDRWRDAIERLHATNNFPEFTGRLCPAPCEASCVLGINQDPVTIKQVEVEIIDNAFDQGWVVPMLPDVQTGKKVAVVGSGPAGLAAAQQLTRAGHTVTVFERADRIGGLLRYGIPEFKMEKRHIDRRLEQMAAEGTQFRPGVNVGVDITVAQLRLNYDAVVLAGGATAWRDLPIPGRELDGIHQAMEFLPWANRVQLGDDVLGPDGEPPITAKGKHVVIIGGGDTGADCLGTSHRQGAASIHQFEIMPRPPETRADSTPWPTYPLMFRVSSAHEEGGERVFSVNTEEFIGENGHVTGLRAHEVKMNAGKFEKVEGTDFELKADLVLLAMGFVGPEKPGLITDLGVELTDRGNVARDANFQSSVPGVFVAGDMGRGQSLIVWAIAEGRAAAAGVDRYLMGRTALPAPIKPTAAPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFV2</accession>
    <name>A0A132PFV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LytTR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855020.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22710"/>
    <dbReference type="EnsemblBacteria" id="KWX21228">
        <property type="protein sequence ID" value="KWX21228"/>
        <property type="gene ID" value="AFM11_26625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3196"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="2">
        <location>
            <begin position="72"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="32360" checksum="13B178F63D52582B" modified="2016-06-08" version="1">MTLFMIGVLAIIAGGVWIDTSLQRIPALADYPERPGSGRGTTWLLVGSDSRQGLTPDQQAELATGGDIGTGRTDTILLVHIPGIGADAPATMVSIPRDSYVPIPGYGEDKINAAFSLGGAPLLAQTVELATGLHLDHYAEIGFDGFAALVDAVGGVTMCPAEPISDPLAGIDLPAGCQVLDGRNALGFVRTRATPRADLDRMVNQREFMSALLHRAASPSVLLNPLRWYPMARAAGGTIAVDEGAHVWDLAWLAWALRGDLLTTTVPIGEFTGSDSGAVVVWDSDAASRLFDALATDAAIPPDVINTPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFW4</accession>
    <name>A0A132PFW4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854999.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22755"/>
    <dbReference type="EnsemblBacteria" id="KWX21221">
        <property type="protein sequence ID" value="KWX21221"/>
        <property type="gene ID" value="AFM11_26580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3186"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="379" mass="40776" checksum="A833078EA951904F" modified="2016-06-08" version="1">MIIWVIAGLLGLATGLRIGWALVNKQSLVSSAMILALGSLGVVAALNWQPLALLLDTLLRWPNISMGLSQVALIACAAGSCVMITTASSERTPAITRRIAMVQYGIAGVVAVISLVIFFLAGKQPEMSPEEFLRRELGSNGSSWLLPLLYVLLALTLVAWAGLRYSNRSRRGRALFVFTVGIVLIVAASAFFVLRAVGQTRSVGVGTAATLLGCAMVIVAAGSLLPSIEDWFGARQELRTIAPLLSELGRRHPDVGIGVRPRGPLVFRVAERMSLISDSLYLEATAAENKRRKAGGTQGSSASEGNAPVLDAPAVSPRKQARALAQWIYDTREEAGDDRALSAFPGLNWLRQPTSFSDREWILAIAQQYRELDRGQKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFZ1</accession>
    <name>A0A132PFZ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855534.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06685"/>
    <dbReference type="EnsemblBacteria" id="KWX21127">
        <property type="protein sequence ID" value="KWX21127"/>
        <property type="gene ID" value="AFM11_26835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3238"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="100"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="218" mass="22601" checksum="3D3E5721F9843CF2" modified="2016-06-08" version="1">MYAQILLFDGFDPLDVIAPFEVLSAGSDSIGGELIVELVAAEGPRLVVSGNRGLALQATGRLDPEKPGFVIVPGAAGPVDGDPDEGAVTIPVLLARFGETAAVKLMRRAMANPDIVVACVCGGSLALAMAGLLEGRRAVTHHLGMDVLDATGVTPIAARVVDDGDLVTSGAVTSGLDLALHLLHRTYGPRIALAVESLFDYERRGTVWTDTGRHAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG15</accession>
    <name>A0A132PG15_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrate ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_25475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854380.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24805"/>
    <dbReference type="EnsemblBacteria" id="KWX21286">
        <property type="protein sequence ID" value="KWX21286"/>
        <property type="gene ID" value="AFM11_25475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2957"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="245" mass="27384" checksum="90B6720F5FE68132" modified="2016-06-08" version="1">MASIEVRSLVKDFHDRHGHRTRVLDGIDLTISGETFVSVVGPSGSGKTTLLNIVSGIETHTSGSVRLRSGERDARVGYVFQDPRLLPWRTVMGNLGFVQRERDGWEQRAQHYLDLVGLGHVGERYPAQLSGGQQQRIGIARAFSVEPDVLLMDEPFSHLDAMTSRTLREHLERIWLETRRTVMFVTHDVTEAVQLSDRIVVLAPGGRIHEIIEVDLPRPRRASDPTVAVLQAEVLARFEALEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG42</accession>
    <name>A0A132PG42_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25740</name>
        <name evidence="3" type="ORF">AWC31_36155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854506.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36155"/>
    <dbReference type="EnsemblBacteria" id="KWX21329">
        <property type="protein sequence ID" value="KWX21329"/>
        <property type="gene ID" value="AFM11_25740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12047">
        <property type="protein sequence ID" value="ORX12047"/>
        <property type="gene ID" value="AWC31_36155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3012"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012788">
        <property type="entry name" value="Decarb_PcaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02425">
        <property type="entry name" value="decarb_PcaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX12047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="122" mass="13623" checksum="D9EA90098ECCD6B0" modified="2016-06-08" version="1">MTTHEDGMTVRREVLGDDHVDRAVAATTDFTADFQDLITRYAWGEIWTRPGLDRRSRSMITLTAMIARGHHDELAMHVRAALRNGLTVDEIKEVLLQSAIYCGVPDANTAFRIAGRVLAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGA0</accession>
    <name>A0A132PGA0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855043.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22665"/>
    <dbReference type="EnsemblBacteria" id="KWX21237">
        <property type="protein sequence ID" value="KWX21237"/>
        <property type="gene ID" value="AFM11_26670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3205"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043776">
        <property type="entry name" value="DUF5718"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18985">
        <property type="entry name" value="DUF5718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="29076" checksum="4E9FE48BF358B95A" modified="2016-06-08" version="1">MIDIDLAEVRNWFGFGVAGNFAGHLEQAGEAGDFVKVVTEGYAPKGIFPWYAPGRDDFLGEFPLSSDTILLPATAEGDGPLNLQIEPEVGVACHVVWNGDTVVRLEPFALGAFNDCSIRRPNAPKISYKKNWGPASKGVASQFFEISDLTPDGPTADMRLVCYLRDDGGQQHAYGVDSPLVGYSYYGEVLLDWIVERLANQKGSADTPLEDVGALMVASGHPENVLIGIGATRYTPLGESTYLKPGDEAIVRVYDSASSAASELRQVVSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGB2</accession>
    <name>A0A132PGB2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl carrier protein</fullName>
            <shortName evidence="2">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acpP</name>
        <name evidence="5" type="ORF">AFM11_26975</name>
        <name evidence="6" type="ORF">AWC31_06825</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyl carrier protein involved in meromycolate extension.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="2">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036443195.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06825"/>
    <dbReference type="EnsemblBacteria" id="KWX21032">
        <property type="protein sequence ID" value="KWX21032"/>
        <property type="gene ID" value="AFM11_26975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09912">
        <property type="protein sequence ID" value="ORX09912"/>
        <property type="gene ID" value="AWC31_06825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3269"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2 3">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="99" mass="10749" checksum="C68C7E63BA9A47CB" modified="2016-06-08" version="1">MPASQEEIIAGLAEIIEEVTGIEPSEVTPEKSFVDDLDIDSLSMVEIAVQTEDKYGVKIPDEDLAGLRTVGDVVAYIQKLEEENPEAAAALREKFAADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGS9</accession>
    <name>A0A132PGS9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cystathionine gamma-lyase</fullName>
            <ecNumber evidence="6">4.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_25000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854108.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27255"/>
    <dbReference type="EnsemblBacteria" id="KWX21474">
        <property type="protein sequence ID" value="KWX21474"/>
        <property type="gene ID" value="AFM11_25000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2361"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080146">
        <property type="term" value="F:L-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044540">
        <property type="term" value="F:L-cystine L-cysteine-lyase (deaminating)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="372" mass="38594" checksum="EE4F0CC510A4CFAF" modified="2016-06-08" version="1">MDGTYGDSTRSVKAVGIEAVPGSPVAPMPVPASTFHLSPDETEQLDSYGRTSNPSWRQLETALAELEGAAAALTFGSGMAAITSVLRVLAKPGSTLLVPADGYYQVRRYAAEYLAAQGVTVIEAHAAEMCEAASAADVVLAETPANPGLDVVDLHRLAMTCRRRGATLVVDNTTATPLGQQPLSLGADLVVASATKSLSGHSDLVAGYVAGSQPDLMAAVERDRLLAGPILGAFEAWLVLRSLGSAGLRFERQCQNARALAVMLRSHPAVVSVRYPGLPDDPAHELAAAQMKRFGGLVAVELADAGAVHALVEHSELLIASTSFGGIHTSVDRRARWGDPVPPGFARISAGIEDTDDLLGDVEAALSAAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGT3</accession>
    <name>A0A132PGT3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell motility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854368.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27805"/>
    <dbReference type="EnsemblBacteria" id="KWX21568">
        <property type="protein sequence ID" value="KWX21568"/>
        <property type="gene ID" value="AFM11_25445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2452"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453069" evidence="1">
        <location>
            <begin position="46"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="103" mass="9912" checksum="3FD6B0CAF54CD7D3" modified="2016-06-08" version="1">MTLRILPEGLSAAGTAVEALTARLAAAHAAAAPMVSTVVPPAADAVSLQTATGFSAHGAQHSALAAHGVEELGRSGVGVAESGASYATGDAMAASSYLIARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGV1</accession>
    <name>A0A132PGV1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="10" type="ORF">AFM11_25120</name>
        <name evidence="11" type="ORF">AWC31_27440</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854160.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27440"/>
    <dbReference type="EnsemblBacteria" id="KWX21494">
        <property type="protein sequence ID" value="KWX21494"/>
        <property type="gene ID" value="AFM11_25120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14883">
        <property type="protein sequence ID" value="ORX14883"/>
        <property type="gene ID" value="AWC31_27440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2385"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="161"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX14883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="230" mass="24141" checksum="B86FB5C4615425B7" modified="2016-06-08" version="1">MTDSHAALLAALGVALPEELLTIALTHRSYSYENGGLPTNERLEFLGDAVLGLTITEELYHRHPDRSEGDLAKLRASIVNTQALADVGRGLSDGGLGAHLFLGKGEENSGGADKSSILADGVESLLGAIYLEHGLEVAREVILRLFGELLDTAPTLGAGLDWKSSLQELTAARGLGAPSYVVTSTGPDHDKEFSATVVVGSVEYGRGVGRTKKEAELKAAANAWHALDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGV5</accession>
    <name>A0A132PGV5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853462.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21579">
        <property type="protein sequence ID" value="KWX21579"/>
        <property type="gene ID" value="AFM11_23875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2133"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="158" mass="17507" checksum="6608C83C1481DAF4" modified="2016-06-08" version="1">MNLGPWGDLTILAAVMEIVFATCVFIYIGRLERRTPHPLGDQVGAHKAVLARIRKRQPMTRDEVDYANELIADARSPLAYAIPAALFTMGFFYVVGCLFMLHLDGGHPSFRTFIGGIPMLTSMNMAGQLRRVARLKRKLPQVPVVEHEATDATVRVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH05</accession>
    <name>A0A132PH05_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853625.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21629">
        <property type="protein sequence ID" value="KWX21629"/>
        <property type="gene ID" value="AFM11_24175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2194"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="239" mass="26080" checksum="87675E033C53E202" modified="2016-06-08" version="1">MTITYDDALRARIRTHLDGHDRRVVTDPTKRHAAVAVVLVDSELGEDRVDPAPVDDWIGGRPMPEPGLDGRMVDVSGGAAFLLCRRASRLNSHAAQWALPGGRLDPGETAVDAALRELDEELGVRLPDSTVLGLLDDYPTRSGYVITPVVVWGGGRLELSPSPDEVVAAYRVGLHQLQRDDSPRFIDIPESTRPVVQIPLGNDLIHAPTGAVLLQVRWLCLEGRNDAVGDLEQPVFAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH83</accession>
    <name>A0A132PH83_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DeoRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24010"/>
    <dbReference type="EnsemblBacteria" id="KWX21718">
        <property type="protein sequence ID" value="KWX21718"/>
        <property type="gene ID" value="AFM11_24120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2183"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DeoRC" evidence="1">
        <location>
            <begin position="43"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="26169" checksum="FEE59230CF571996" modified="2016-06-08" version="1">MTIHRDLDHLHAQGMLRKVRSGAEAPPSEAFERNIDLRKALNLAEKRAVAATGFDWAASQVEMQAVAMDDSTTALHVLPRLSERLPLTVVTNFLPAINELSTDPRVRLNAIGGDYVPEFSSFVGAQAVRALRDMHYDVLFMSVTAVSRGMCFHPSSAAAELKRAFMESAELRVLLIDHTKLARRAIHRICALEDFDAVVIDAGVGADDMEQLEATGANIIVAQPDPTLTAELELSGATPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHY2</accession>
    <name>A0A132PHY2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852806.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08515"/>
    <dbReference type="EnsemblBacteria" id="KWX21968">
        <property type="protein sequence ID" value="KWX21968"/>
        <property type="gene ID" value="AFM11_22690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1888"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CHK" evidence="1">
        <location>
            <begin position="119"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="665" mass="72000" checksum="A2E3EBEE19C21D73" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI10</accession>
    <name>A0A132PI10_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_22725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08480"/>
    <dbReference type="EnsemblBacteria" id="KWX21975">
        <property type="protein sequence ID" value="KWX21975"/>
        <property type="gene ID" value="AFM11_22725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1897"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="268" mass="29059" checksum="BDC1914370A5CD9C" modified="2016-06-08" version="1">MTSPTELAAPAAAVANRRSSERKWGVIRLISPVVLLALWQLGSAVGVISQDVLPAPSLILEAGIELIRNGQLADALQVSGIRVVVGLLLGGLVGVALGTAVGLSRWLEATVDPPMQMIRALPHLGLIPLFILWFGIGELPKVLLVALGVSFPLYLNTFSAIRQVDPKLFETAQVLGFSFWQRFRTIIVPSAAPQVLVGFRQSLAIAWLTLIVAEQINADKGIGFLINNARDFLRIDIIIFGLIVYALLGIGTDAIVRMLERRALRYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PII9</accession>
    <name>A0A132PII9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852527.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04860"/>
    <dbReference type="EnsemblBacteria" id="KWX22178">
        <property type="protein sequence ID" value="KWX22178"/>
        <property type="gene ID" value="AFM11_22055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1759"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453320" evidence="1">
        <location>
            <begin position="29"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="194" mass="21779" checksum="A4FBCC5555280F1B" modified="2016-06-08" version="1">MAARLRLLSALSALVAAVILVCQTGPSAGSQGGVLQLESTDLPMTNVSTTIKWPVIETTDPSPFDPCRDIPLDVVQRIGLAFTPPTPEDSLRCKYDAGNYQMAVEAFVWRTYEATIPPDALELDIDGHRAAQYWIMKPTDWNDRWWITCMVAFKTSYGVIQQSLFYSPIYSEPDPDCLQVNLQRAHELAPYYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIK4</accession>
    <name>A0A132PIK4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852363.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04355"/>
    <dbReference type="EnsemblBacteria" id="KWX22094">
        <property type="protein sequence ID" value="KWX22094"/>
        <property type="gene ID" value="AFM11_21540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1656"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="30551" checksum="33211B8E117E1F83" modified="2016-06-08" version="1">MRAVASVAGLLEVFDVAPSGPDRFIGTTGAIGTDGRHGAKGAQALGQAIVAAAKRFPDKVIRSAHAIFARPIAVASTVELFVDVVHEGRSTATAVVGVSQDSRRCATVTVLADVPSPDVISHQALRPDVDTPDDARPATQAMAGHDLRLVDVVDVNSPDEVGPPELYAWLRYDPIPDRDDLAKALLAYFTGQLGISTTMRPHRGIGTAQAHVTVSTALMSTFISFHEPVQWDAWLLYGHESTQAGAGMSYVRGQVHTEDGDLLASFAQEGLIRPIRSADAAFDTPARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIS9</accession>
    <name>A0A132PIS9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C4-dicarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_20695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852045.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06110"/>
    <dbReference type="EnsemblBacteria" id="KWX22259">
        <property type="protein sequence ID" value="KWX22259"/>
        <property type="gene ID" value="AFM11_20695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1476"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="463" mass="48936" checksum="03A771A616F00CA6" modified="2016-06-08" version="1">MATTIDPPQSEMIRLANKPPWYTSLFIQLFVAIVAGIAVGWLWPEFGESLKPLADGFIKLIKMLIAPIIFCTVVLGIAHVGDLKSVGRIGVKALIYFEAVTTFALLFGIVVGNIVKPGSGFSIDPQTLATGAEAVAAKTNDGELPHTVEFLLNIIPSSVISAFAENALLQVLFFAVLFGLALAKFGESGPPVILEFVDHLSHIFFTIIGWIMRLAPVGAFGAMAYIIGQYGIGSLGSYAKLIAACYAAAALFIVILAVIARLFAGVNLWRFLVYIKDEMFLALGTASTEVVLPRIMTKLTNAGCSRTTTGLVVPTGYSFNLDGATLYLSICVLFLAQALGVDLSLGEQITAVLVLMLTSKGMAGVPGSSFLALSATVAAIGHGAIPVAAVALLLGADRIMDSMRVSVNLLGNCVATFVVAAWEGQLDKERMRKVLAGEDVAPLEDVGPEEEQRVPGPISTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIU0</accession>
    <name>A0A132PIU0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20760</name>
        <name evidence="4" type="ORF">AWC31_06175</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852068.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06175"/>
    <dbReference type="EnsemblBacteria" id="KWX22269">
        <property type="protein sequence ID" value="KWX22269"/>
        <property type="gene ID" value="AFM11_20760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09801">
        <property type="protein sequence ID" value="ORX09801"/>
        <property type="gene ID" value="AWC31_06175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1491"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="122" mass="13316" checksum="55A0B5722C852CF4" modified="2016-06-08" version="1">MKTISSLADDQHADAHQHHGAPAPELPPREVLDTAGELLRALAAPLRIAIVLQLQQSQRCVHELVDALGVPQPLVSQHLRILKQAGVVSSERAGREVLYRLVDHHLAHIVVDAVAHAGEDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIV2</accession>
    <name>A0A132PIV2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852088.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06240"/>
    <dbReference type="EnsemblBacteria" id="KWX22280">
        <property type="protein sequence ID" value="KWX22280"/>
        <property type="gene ID" value="AFM11_20825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1503"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="301" mass="31954" checksum="63ED061D016AB406" modified="2016-06-08" version="1">MELRQLEYFVAVAEEESFTKAAARLHIAQSGISAQILQLERELGQRLFDRNRRAVRLTEVGTAVLKHARLALAAAEDARQIADEYGDALRGHVSVGLAASSSYAFDLADMLAKFHRDHPLVEISLQETGSDELVAGLLAGRQDAAIIAPPAVVPPDLGLQLVADEPLVAAVSPDHPLATAIDITLDDLSGCQLITFSPMVGTRSTIDATLAAAGIEAHIGIEAGDPSVLAELAVGGLGVALVPEPYARARDGQLRVLPIRDVQLRGSLALAWNNARQPTPSARRLIDYARQSLSAKYGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIZ6</accession>
    <name>A0A132PIZ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852162.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22316">
        <property type="protein sequence ID" value="KWX22316"/>
        <property type="gene ID" value="AFM11_21020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1548"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="43"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="352" mass="38935" checksum="732A800BE9B36B8F" modified="2016-06-08" version="1">MPASEKMPLSPMLVQYLVGLCALKWDASAVNVDVTLGDMVEDAASGTRRDVDVTVTADTPEGLYAFKGYEVKHWSSPLDVADVEALALKLKDMPSVTHRAIVSTSGYTAPAIRKAEHHGVDLFVLKRWTKPIEVQPPEPAPVTGFPLQNINMLNLNLVWPVRGFWMGTEGPPFHIESDAKLFDAEGAQHKDHGSFGAYASAMTIRSTGILLNVAPIADRARGLMEAFWNHIEMPEEPQWPWTHTLDSAADEVYIRSSDEKLYRVDTFTIYGELKWEIQGTLYCVMEKVPTGDVFASAVVGLSDVPGRMSAMIIPAEGRTLHIHDHIQLEPKHLNSIRDLKIALPTEENAVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ85</accession>
    <name>A0A132PJ85_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19765</name>
        <name evidence="4" type="ORF">AWC31_11105</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX09025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851838.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11105"/>
    <dbReference type="EnsemblBacteria" id="KWX22395">
        <property type="protein sequence ID" value="KWX22395"/>
        <property type="gene ID" value="AFM11_19765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09025">
        <property type="protein sequence ID" value="ORX09025"/>
        <property type="gene ID" value="AWC31_11105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1287"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453337" evidence="1">
        <location>
            <begin position="25"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="37"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="349" mass="36367" checksum="78B6C9B97A5F5B1A" modified="2016-06-08" version="1">MKLGTKMFAVASATVLGFGMTACGAGDPEANSDTTRIGVSVYDMSSFITAGKEGMEAYAKDNNIELVWNSANLDVSTQANQVDSMINQGVDAIIVVPVQADSLGPQVASAKAKGIPLVPVNAALNSPDVAGNVQPDDVAAGAQEMQMMADRLGGKGNIVILQGPLGQSGELDRSKGIEQTLAKYPDIKVLAKDTANWKRDEAVNKMKNWISGFGPQIDGVVAQNDDMGLGALQALKESGRTGVPIVGIDGIEDGLNAVKSGEFIGTSLQNGTVELSAGLAVANALAKGEEVNTEPVYIMPAITKDNVDVAIQHVVTERQKFLDGLSELTAQNLKTGDIAYEGIPGQKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJC3</accession>
    <name>A0A132PJC3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851883.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28510"/>
    <dbReference type="EnsemblBacteria" id="KWX22440">
        <property type="protein sequence ID" value="KWX22440"/>
        <property type="gene ID" value="AFM11_20005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1336"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="244" mass="26009" checksum="A23E0DF33E3A7080" modified="2016-06-08" version="1">MTAPDRPALAGMSIGAVLDLLRGDFPDVTISKIRFLEAEGLVTPERTASGYRRFTAYDCARLRFILTAQRDQYLPLKVIKAQLDAQPDGELPQAGSAYAVPRLVTVAGETDGDGTPGVSAVAPTQVRLSREDLLARSGIDEELLGALVKNGVITTGPAGLFDEHSVVIAQCARALADYGVEPRHLRAFRSAADRQSDLIAQIAGPVVKAGARDRADDLAREVAALAITLHTSLIKSAVRDVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJS7</accession>
    <name>A0A132PJS7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">secA</name>
        <name evidence="15" type="ORF">AFM11_20040</name>
        <name evidence="16" type="ORF">AWC31_28475</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000016">
        <property type="protein sequence ID" value="ORX14036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851889.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28475"/>
    <dbReference type="EnsemblBacteria" id="KWX22447">
        <property type="protein sequence ID" value="KWX22447"/>
        <property type="gene ID" value="AFM11_20040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14036">
        <property type="protein sequence ID" value="ORX14036"/>
        <property type="gene ID" value="AWC31_28475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1344"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026389">
        <property type="entry name" value="SecA_Actinobact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04221">
        <property type="entry name" value="SecA2_Mycobac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="14">
        <location>
            <begin position="13"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="96"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="426"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="112"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX22447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX14036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="781" mass="85094" checksum="7ED0BAA7259165E5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK53</accession>
    <name>A0A132PK53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalamin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_19525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851766.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22683">
        <property type="protein sequence ID" value="KWX22683"/>
        <property type="gene ID" value="AFM11_19525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1238"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="445" mass="45393" checksum="D790F4E6D6628C92" modified="2016-06-08" version="1">MDTTAVETSAPPAGRHEPGLGEEYENEPVPPSARRSLFSVSAVWVGFPMIMTSAVFAGIVVYNLGFVTGMLAIIVGDLILMGYVGTLSYLAGRSGKNFALTAADTFGTKGFRVVSAFLSTLVIGWFAFQTGMVGTTLNLSMGWSAAWITLLAGVLFVALTFVGIRAISWIGVVASALFIPLGAVAVILAASASDGLGSAVSYGGGAGAAAFSFGVAVTMVFACFVDSGTMTADFTRWARNGKEGALAAFAAFPVAYFVAQLVGALIVALGAAAAPGTAGGDFLHVLVGGGGILVPLAIAFVFVNLGSVCAHCLYNGAVGFGNITGKTMRQLTIVLGIVGTIAAVAGIWSYFATWLNILGVLVPPIGIVLILDQLVFAHRRASTGGLHWKPFAAWAIGAAVALATHWYAPQLSDAVVAMVVGGLAFTALAYLPARTAQPALGGEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKC1</accession>
    <name>A0A132PKC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851915.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11535"/>
    <dbReference type="EnsemblBacteria" id="KWX22472">
        <property type="protein sequence ID" value="KWX22472"/>
        <property type="gene ID" value="AFM11_20180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1371"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="212" mass="23765" checksum="69F83C3B9100276C" modified="2016-06-08" version="1">MTDAGAVTHPVRLRMRRLLVGRRLTARLGGDTAALTVTDVESRLDARTLAAGHLGRVHLGARDIRWRDLRFARATVTLHNVHIRPSVPPVVVARPVELTLEAASPALDELLARTVPRLRVQVGGDGLARLRLARRPRLGHVELDVRLDGSTLRFVPTRLVVGRRRWAVPRRTPSYPVRLPELPHGLQVTAIRFTPHLLRVEATLPEWQARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKF2</accession>
    <name>A0A132PKF2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851191.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22815">
        <property type="protein sequence ID" value="KWX22815"/>
        <property type="gene ID" value="AFM11_17895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.933"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="670" mass="69583" checksum="E82B23F7DA3BEE9A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKH4</accession>
    <name>A0A132PKH4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_18100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22845">
        <property type="protein sequence ID" value="KWX22845"/>
        <property type="gene ID" value="AFM11_18100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.977"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="21861" checksum="A48CD79253EE13E0" modified="2016-06-08" version="1">MSGERRRRLVDVAAAEFASVGYREASLNRIIAKCGMSKSSFYYVIESKDELFEFVMAELLGGLANAVEIPEPEKFRGPDYWPRVEAFFAHLVTVSQREESALTLGRMFYSDAPGGDASAGMLAAVRQWVEEVLRVGRSCGAVRSDLPEALQCSVVLRILQVFDEWTVAHFDEVGPENLDGLAAAQFATVRRVLESSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKM4</accession>
    <name>A0A132PKM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_18530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NlpA lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12555"/>
    <dbReference type="EnsemblBacteria" id="KWX22888">
        <property type="protein sequence ID" value="KWX22888"/>
        <property type="gene ID" value="AFM11_18530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1040"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="298" mass="31632" checksum="72C879D02B64B6A5" modified="2016-06-08" version="1">MAVIAAVSVVATAAGCSNDVSVTYSENIPGEVLRVRVGGEGYRDVLDYVSKAKLTGDVRLELVDASADANDHVADGRADLAFYQTQPAFLGEQETNGHGTLSIVSKVDVAPYALYSSRWKDLEPTDDWVNSNLVSDKITGQSLPHGAEVAVPQTKAGFARSLYLLQTAGLVKLDRPFGGLTVADLSVSDANVVESQRHLAIRGIDFAEYAEDIYHNYDAVVLDPTTATSIGLIPAKDALAIEPGPGNPYARVLVAPSRLAGDPRVSALAHALESKEVAHYLAITYHGKFISAQVPFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKQ4</accession>
    <name>A0A132PKQ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_18170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851445.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12240"/>
    <dbReference type="EnsemblBacteria" id="KWX22930">
        <property type="protein sequence ID" value="KWX22930"/>
        <property type="gene ID" value="AFM11_18170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.991"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453145" evidence="3">
        <location>
            <begin position="29"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="420"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="523" mass="53856" checksum="38005BDE46482721" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL39</accession>
    <name>A0A132PL39_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16420</name>
        <name evidence="3" type="ORF">AWC31_19900</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850619.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19900"/>
    <dbReference type="EnsemblBacteria" id="KWX22964">
        <property type="protein sequence ID" value="KWX22964"/>
        <property type="gene ID" value="AFM11_16420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16327">
        <property type="protein sequence ID" value="ORX16327"/>
        <property type="gene ID" value="AWC31_19900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.632"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="214" mass="22716" checksum="3AB11575BF12FE94" modified="2016-06-08" version="1">MTVAMADQETRTVVLRRRIVVGVVLVAGAMLQAYSLGREPGDTSFYWLTLAMAAVWTVGAIVSGPLQLGRDRRPIVLGTVVGLGLGAMFAVGGLIARLIPGLREYVTAVLEFANHGPLLVIVFITVINGVAEELFFRGALYTALGNHYPAVISTVIYVAAVMAAGNPMLGFAGILLGAVCAYERRMTGGVLAPMLTHFFWGLIMVLVLPPIFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL54</accession>
    <name>A0A132PL54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851425.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22917">
        <property type="protein sequence ID" value="KWX22917"/>
        <property type="gene ID" value="AFM11_17820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.919"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="270"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="366" mass="39211" checksum="CFEE309B5978893D" modified="2016-06-08" version="1">MDAADRVLGSVRALLPSIADTAADVDRAGAVDPEVLLALHDAGYFTMLQPARFGGLQARPDSFLTVTRELSAACASTGWLAGWLAVNSWHLALFDDRAQDEVWGADPRALVATSYGPTGRLERIAGGFRLSGRWNHCTGIGQASWLLAAALLVAPDGSAEDFLVALVPRSDYTIEPTWNGLGLRGIGADDAVVPGAGVEVPAYRTFGFVSTDQLATLPPLYRLPQPTLYSHTGTMPLQGAALRLLAGVPPGPALDPIEMARSGVELSMLQIRRNLTDLMDSVESGSGPDSDLILRSRRDQVVASERAIQAVQTVVRNPPPGFDEALAERLWRDVQTARNHVASNVDQVLSVVGRFAYGLRVDDLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL81</accession>
    <name>A0A132PL81_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_17215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23100">
        <property type="protein sequence ID" value="KWX23100"/>
        <property type="gene ID" value="AFM11_17215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.796"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="113"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="290" mass="31467" checksum="CC35C9BAF97A764C" modified="2016-06-08" version="1">MSYPYPPQSPAETPTCYRHPDRQTYVRCTRCGRYICPECMRAAAVGHQCVECVNEGAKSVRAPRTQFGGVQRSGAPLLTYGLIAVNVVMFVLQMASGNLESQFTLWPPGIALHDQWYRLVTSMFLHYGAMHLLFNMWALYVVGPPLEAWLGRLRFGVLYALSGLGGSVLVYLLSPLESATAGASGAIFGLFGAIFIVARQLNLDVRWIGAVVVLNLVFTFAGPALGAGAISWQGHIGGLVTGALVAAAFVYAPRERRNVIQAGVSVAFVLLFAAAVWWRTNDLLTTFGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL89</accession>
    <name>A0A132PL89_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850931.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01845"/>
    <dbReference type="EnsemblBacteria" id="KWX23110">
        <property type="protein sequence ID" value="KWX23110"/>
        <property type="gene ID" value="AFM11_17280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.809"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="70"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="296" mass="33673" checksum="7600E3B6A37E655C" modified="2016-06-08" version="1">MLPNERIDYSAITDRPRLQLPGGARLAVWIIVNVEEWSPLEPMPRTVLTPPAGGTPTPDVPNWAWHEYGNRVGFWRLLQAIDAHEVPAALAINGSAIASYPEITQAAIARKWEPIGHGYTQKNMQKVTDERVDIQLTTQAIERAWGRPPRGWLGPGLTETWETPELLVDAGYSYVCDWVLDDQPVELRTERGPLVNIPYTQECNDVAMMLIQHHPAQEYYQRAIDQFDQLYADSAESARVMALVVHPYIMGVPHRAKYFADALAYMRRRDDVVFWTGEQILDWHLESRRPVSHAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLA8</accession>
    <name>A0A132PLA8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carbonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_17370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850967.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01950"/>
    <dbReference type="EnsemblBacteria" id="KWX23128">
        <property type="protein sequence ID" value="KWX23128"/>
        <property type="gene ID" value="AFM11_17370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.827"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="713"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX23128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="737" mass="76411" checksum="8380ABBDF27DFA05" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM76</accession>
    <name>A0A132PM76_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_14205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849748.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09195"/>
    <dbReference type="EnsemblBacteria" id="KWX23438">
        <property type="protein sequence ID" value="KWX23438"/>
        <property type="gene ID" value="AFM11_14205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6947"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="18"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="327" mass="32860" checksum="BA8C05AF97671C6A" modified="2016-06-08" version="1">MIVTVTPNPSLDRTVTLATALTRGAVQRVDSVTVEPGGKGINVARALTLAGVDAVAVLPAADTDPLLVALRAQGVPFTGVPITEPVRTNLAITETDGTTTKLNERGARLDAAALDALTQCVVAKAEHASWVVLSGSLPPGVPDDWYAHVVRLLAPMPCRVAVDTSEKPLAELAAAFGVAAPDLIKPNGEELASIVGASPAALETAAAQGDLSPVVSAAERLVARGVGSVLATLGAAGAVLVNTTGAWLATPPPIVPRSTVGAGDASLAGYLRAAVGGVEPPRRLRMAVAYGSAAAALPGSALPAPAQLDLDAVRVTPLVTTNPEVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM77</accession>
    <name>A0A132PM77_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_16480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850999.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19840"/>
    <dbReference type="EnsemblBacteria" id="KWX23142">
        <property type="protein sequence ID" value="KWX23142"/>
        <property type="gene ID" value="AFM11_16480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.645"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="187"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="341"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="415" mass="45179" checksum="3F2207EB01C36429" modified="2016-06-08" version="1">MAWNPPSPRVRELIRQCAQIVVNARPEWLDELDRAVLAAANPVIAADPELAAAVSRSNRANLYFWGTANVRDPGAPVPPNTGPEPLNIARELVRRGVNAFPLDAYRVGEGVAWRRLMEIAFELTSDPTELHELLDVCSRSISAFVDATLAGITTQIELERDELTRGSHAERRETVALLLDGAPIPRQRAEARLGYALTGPHTAAVIWSDQPDGDLSELDRAADAFGQACGGARPLSVLASTATRWVWAPGPVDAAALEHAIDDTGDIRIAIGPADDGVDGFRRSHFDAITTQQMMARLHSPQQIARFAEIELVALITADPDRAAGFVKRTLGDLETAGTELQETVRIFVAEQCNASRAAARLYLHRNTLLRRLARADELLPRPLADCTVNAAIALDVLRWHGQPDARDQSNAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMD5</accession>
    <name>A0A132PMD5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor WhiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14350</name>
        <name evidence="3" type="ORF">AWC31_18470</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849798.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18470"/>
    <dbReference type="EnsemblBacteria" id="KWX23463">
        <property type="protein sequence ID" value="KWX23463"/>
        <property type="gene ID" value="AFM11_14350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17290">
        <property type="protein sequence ID" value="ORX17290"/>
        <property type="gene ID" value="AWC31_18470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6978"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="97" mass="10839" checksum="710896D29BAD7414" modified="2016-06-08" version="1">MNALMANGIPLGVCTSDPERWTSTPDDEAKVICRECPRRWLCAREACELPRAEGLWAGIMVPEGGRGRTFALKQLRSLAERHGYPVRKTRLIFPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMH2</accession>
    <name>A0A132PMH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15580</name>
        <name evidence="3" type="ORF">AWC31_16205</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16205"/>
    <dbReference type="EnsemblBacteria" id="KWX23242">
        <property type="protein sequence ID" value="KWX23242"/>
        <property type="gene ID" value="AFM11_15580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17949">
        <property type="protein sequence ID" value="ORX17949"/>
        <property type="gene ID" value="AWC31_16205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7233"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="313" mass="33326" checksum="93FF6392AD2D8614" modified="2016-06-08" version="1">MRTLVTGAAGFIGSALVDRLLADGHSVVGLDDLSTGRVDNLSDADNDKNFEFVKADIVDADLIGLLAEIKPEVIFHLAAQISVKRSVDDPQLDATVNVVGTVRLAEAARQTGVRKVVHTSSGGSVYGTPPAYPTSEDMPTDPASPYAASKVAGEVYLNMFRNLYDLDCSHIAPANVYGPRQDPHGEAGVVAIFAQALLAGRPTKIFGDGSDTRDYVYVDDVVDAFVKASGTEGGGQRFNVGTGVETSVRQLHSAIAKAVGAADEPEFYPPRLGDLRRSKLDIGRARTVLGWQPAVELADGVEKTVDFFRNNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMI8</accession>
    <name>A0A132PMI8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_14910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849984.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17990"/>
    <dbReference type="EnsemblBacteria" id="KWX23551">
        <property type="protein sequence ID" value="KWX23551"/>
        <property type="gene ID" value="AFM11_14910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7093"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453183" evidence="8">
        <location>
            <begin position="28"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="368"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX23551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="589" mass="62459" checksum="88448D8F71B82F9B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PML2</accession>
    <name>A0A132PML2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="146317">
        <property type="entry name" value="M.MwoCDC01ORF15840P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23282">
        <property type="protein sequence ID" value="KWX23282"/>
        <property type="gene ID" value="AFM11_15840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7293"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029464">
        <property type="entry name" value="HSDR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13588">
        <property type="entry name" value="HSDR_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSDR_N_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="233"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="567" mass="64176" checksum="700BA6B3642882F6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMM4</accession>
    <name>A0A132PMM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_15900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16475"/>
    <dbReference type="EnsemblBacteria" id="KWX23292">
        <property type="protein sequence ID" value="KWX23292"/>
        <property type="gene ID" value="AFM11_15900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7305"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="497" mass="53355" checksum="5465DA3A7DA9D561" modified="2016-06-08" version="1">MTSARYSRPMTVLPRGGRPRRGGRRPGWLLLTVLLVLAILASSALVFTDRVELLKLAVILALWAAVVAAFVSVIYRRQSDLDQAKARDLKLVYDLQLDREISARREYELTVETQLRRELASELRAQAADEVAALRAELAALRANLEILFDTDLAHRPAIETDKSAVRSAGRVKASRLDVPEVRDVEATDIRSVRTEESPIIDVPAEPHPPENDWPPTPPADGGAHRFPSQRPPAPEQPRRRRRQAEEQQAPPRKPEPQPAPPPAPQPAARQTERPAEEPAARRHAMDARPEPRQPEPQSAWAPPPPPPTMPPLQPSPTIDAPKPEPRSEPAAAGWTPAPADGQWIPAGAPGSNWSAPVKENGASPEYVGRRRAPEPADAAEPAAPAAPSQAAAPAPPTQAAAPAPPAMSAPAPEPPRGRHSAPADAGDPGRPGAQPAPVLATEPAEPPPPPQPERASRHRSDDEPSGQHAGGQSAAELLARFQAAPTGGGRRRRRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMQ0</accession>
    <name>A0A132PMQ0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0301 protein AFM11_14870</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849971.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18030"/>
    <dbReference type="EnsemblBacteria" id="KWX23544">
        <property type="protein sequence ID" value="KWX23544"/>
        <property type="gene ID" value="AFM11_14870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7085"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00758">
        <property type="entry name" value="UPF0301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="22075" checksum="457DF345C1EBCAF1" modified="2016-06-08" version="1">MAQSEDPEDFIAPAAHRVRPGTLLLASTDLLEPTFRRTVIYIVEHNAGGTLGVILNRPSETAVYNVLPQWAKLTTKPKTMFIGGPVKRDSALCLATLRVGMQADGVPGLRHVQGRIVMVDLDAEPDNLAPMLEGVRIFAGYSGWTIGQLDGEIERDDWIVLSALPSDVLIEPRVDLWGRVLRRQPLPTSLLATHPIDVSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN84</accession>
    <name>A0A132PN84_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849906.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23512">
        <property type="protein sequence ID" value="KWX23512"/>
        <property type="gene ID" value="AFM11_14680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7045"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="1">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="98" mass="10256" checksum="0E4C1011D16ADC91" modified="2016-06-08" version="1">MADSQGLSIRTRELGDAATRLDAIADRLESLLRAEEAQLNTVPVGRDEVSVRASSTLNEVHTSYAKSAALGVTELREVAAALRSSAGNVAAADAEFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNK3</accession>
    <name>A0A132PNK3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848013.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31230"/>
    <dbReference type="EnsemblBacteria" id="KWX23910">
        <property type="protein sequence ID" value="KWX23910"/>
        <property type="gene ID" value="AFM11_11025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6281"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="164"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="894" mass="94870" checksum="6D9B67A85FB51494" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNM9</accession>
    <name>A0A132PNM9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849444.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03840"/>
    <dbReference type="EnsemblBacteria" id="KWX23797">
        <property type="protein sequence ID" value="KWX23797"/>
        <property type="gene ID" value="AFM11_13595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6815"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="209" mass="21885" checksum="03D6D80855235ED1" modified="2016-06-08" version="1">MSLDDIAGIEHRPPGSPKGTVVLTHGAGGSRESPLLIRICDEWASRGWLAIRYNLPYRRRRPKGPPSGSAAGDREGIAEAVALARSLNDGPVLAGGHSYGGRQTSMAVADEGVVVDVLTLFSYPLHPPGKPERARTEHLPRITVPTVFTHGSADPFGTLDEIDAAAALITGPAEVVAITGARHDLGSKTLDVPALAVDAALRRLDIVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP43</accession>
    <name>A0A132PP43_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fis family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_12170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848632.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09805"/>
    <dbReference type="EnsemblBacteria" id="KWX24108">
        <property type="protein sequence ID" value="KWX24108"/>
        <property type="gene ID" value="AFM11_12170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6513"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030937">
        <property type="entry name" value="Hemophore_Rv0203"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032407">
        <property type="entry name" value="MHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038378">
        <property type="entry name" value="MHB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16525">
        <property type="entry name" value="MHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04530">
        <property type="entry name" value="hemophoreRv0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04529">
        <property type="entry name" value="MTB_hemophore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453168" evidence="2">
        <location>
            <begin position="37"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="MHB" evidence="3">
        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="185" mass="18399" checksum="1AB9B596760BFE7C" modified="2016-06-08" version="1">MKPTKGELRRKLAVAFAATAAGGAAVAALLGPSATAASDPCAASEVSRTVGKVATNTGDYLDSHPQTNQALTTILQQQAGPQTLASLKAYFDANPQVAKDMQQLQQPLQSLGTKCKLPVTLPQLLGLMQAAQQQGATLPGGLPGGLPSAQTVGVPSASVPAQSSPASAVTQGAGPLPGPATVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPC8</accession>
    <name>A0A132PPC8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_13550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849623.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03795"/>
    <dbReference type="EnsemblBacteria" id="KWX23892">
        <property type="protein sequence ID" value="KWX23892"/>
        <property type="gene ID" value="AFM11_13550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6805"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="237" mass="24716" checksum="F7F391575AD43627" modified="2016-06-08" version="1">MTARRVLITGASKGIGRAVADRLAAAGHEPVGFARSASPGFPGKLIEVDLSDRAGTDVALATVIADGPVDAVVNNVGLATFARIGSIDLDDLSLNYDVNVRTAVQVVQAVLPGMLAKGWGRIVNVTSLTTLGTAERTPYAASKAALEAATRIWAGELATKGITVNAVAPGPTETEMYRQRSPEGSEREQRFLNTIPMRRVGKPREIAHAICALLDEDAGYLTGQIIRVDGGGSITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPL8</accession>
    <name>A0A132PPL8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitric oxide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848255.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23982">
        <property type="protein sequence ID" value="KWX23982"/>
        <property type="gene ID" value="AFM11_11470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6370"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="150" mass="15797" checksum="1AA77D26DA3913E6" modified="2016-06-08" version="1">MNPVTILFGTESGNSELVADDLCSALERNGIKGEVFGMEDYPIDDLQNQELIFVITSTYGEGDLPETTEPFFAALNAAKPDLSSTKFAAFGLGDSSYETYNQGIGTLSAALTEYGATQLGATGYHDASSGLDPSAVALDWLKTVPVPTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPQ8</accession>
    <name>A0A132PPQ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848378.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30325"/>
    <dbReference type="EnsemblBacteria" id="KWX24022">
        <property type="protein sequence ID" value="KWX24022"/>
        <property type="gene ID" value="AFM11_11700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6417"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="431" mass="44136" checksum="31282AB04788E152" modified="2016-06-08" version="1">MNTLYERDEAVIAGIEKLRFFPLEVVSGHGCTLITPDGRELLDLSATWTASGLGHGHPAVADAVSRAVRTAPGAGGLSAVHPDSVGLAEDLLALVPGTGERRVYLGHAGSDANGVALRACRHATGRRTVLAFEHSYHGGVGVAMGVSGVHVDAGVPADADVAFLPYPNPFRPARDEVGADVAACLDLANRHMATGTVACLIVEPILSDGGLVVPPDGFLADLHEVCRLHGVPMICDEVKMGLGRPGTLHAFEHDGVVPDIVTFGKVLGGGLPLSSAVGPAALLDEPAASALLTTAGNPVCTAAGRAVLATIVGEQLAERAAKVGAVLQDALRALDSDVIGDVRGRGLAIGLELIDPATGGPDPRLAAQVSYRAWELGVVVYYVGGNVLEITPPLILSEEQAVRAADILGSAIDDAAAGKVDAEEVARYAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPU6</accession>
    <name>A0A132PPU6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper resistance protein CopD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_10100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847455.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18580"/>
    <dbReference type="EnsemblBacteria" id="KWX24325">
        <property type="protein sequence ID" value="KWX24325"/>
        <property type="gene ID" value="AFM11_10100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6057"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="8">
        <location>
            <begin position="239"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="670" mass="70654" checksum="92779761454C0F10" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ94</accession>
    <name>A0A132PQ94_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19400"/>
    <dbReference type="EnsemblBacteria" id="KWX24508">
        <property type="protein sequence ID" value="KWX24508"/>
        <property type="gene ID" value="AFM11_10885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6216"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="74" mass="8412" checksum="59DC8CFA9F754F21" modified="2016-06-08" version="1">MMSLLRRVLDHQLSVRQLTYVATTLAVPYLAVGVVWAFGRHEHLERLTGLDRFFSILGEIVAWPVLVIADVHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQE7</accession>
    <name>A0A132PQE7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_10745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847777.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19260"/>
    <dbReference type="EnsemblBacteria" id="KWX24427">
        <property type="protein sequence ID" value="KWX24427"/>
        <property type="gene ID" value="AFM11_10745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6188"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="236"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="382" mass="41866" checksum="D934195C5E748CA8" modified="2016-06-08" version="1">MQRNLFTEDHEAFRTLARDFVEKEVVPQYPEWEKAGRMPRDVFKQLGELGMLGMAIPEEYGGAGISDYRYNVVLQEEAARALVTLSTVRTQLEVILPYFLHYANDEQRQRWFPGLAAGTLLTAVAMTEPGTGSDLAGMRTTAVRDGDSYVLNGAKTFITGGIQADLVVVVARTSTDPDNRRKGLTLLVVEDGMPGFERGRELEKMGCKVQDTAELSFTDVRVPVANVLGEEGEAFSYLGHNLPQERLTVAVGSVAQARSAIAAAIDYTKDRKIFGASVSSFQNTKFELAACSAEVEAAQAMLDRAVALHVDGELSGADAARVKLFCTEMQARVIDRCLQLFGGYGYMMEYPIARLYTDARVARIYAGTSEVMKVIIAKSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQJ1</accession>
    <name>A0A132PQJ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24515"/>
    <dbReference type="EnsemblBacteria" id="KWX24598">
        <property type="protein sequence ID" value="KWX24598"/>
        <property type="gene ID" value="AFM11_07915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5433"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="44"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="171" mass="17498" checksum="6B13C0AFEC327F5E" modified="2016-06-08" version="1">MYNYCSRKHRPSVRIVTVNERNSRVAAAVAAAGIEPAIKILDADAKTAAAAAAQLGCEVGAIANSLVFECDGEPLLVMASGAARVNTDVLAQHLGAHTIAKADAKLVRSATGQVIGGVAPTGHPAPLRTVVDETLASYPLIWAAAGTADSVMPLTYDQLLSLTGGKAVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR43</accession>
    <name>A0A132PR43_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846793.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13260"/>
    <dbReference type="EnsemblBacteria" id="KWX24800">
        <property type="protein sequence ID" value="KWX24800"/>
        <property type="gene ID" value="AFM11_09110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5671"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="238" mass="25967" checksum="6B4D5FFE156A2D71" modified="2016-06-08" version="1">MTQHTIAGQAVTMPVQIRTADQHMAMFSVDADAAQRMIDYSGLQVCRYRPGKAVVILMLMRYVDGDLGQYLEYGTNVMVNPPGSTASGLRALQSAGAFIHHLPVDQAFTLEAGRKIWGYPKVMADFTVRDGRQFGFDVSIDGRLAVGMEFRPGLPVPSVFTSKPQVHPTYSHLDGVTRETAGQMRLFGVRYRLGGARLTLGDHPYAKELAALGLPKRAFISSSAANVQMTFGDAKEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR53</accession>
    <name>A0A132PR53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846707.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24775">
        <property type="protein sequence ID" value="KWX24775"/>
        <property type="gene ID" value="AFM11_08955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453218" evidence="1">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="109" mass="10703" checksum="01C60E2C103FBF17" modified="2016-06-08" version="1">MTSRLLFGAGFAATVAGAAALSLLPGMTPAASASCAPGEESDVFTTVCTPFMVPNSPSPFTSIPGNPDIPAIDGIPCTGRNAGQCIGLAEDAEAAGPQPIPRSTISASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRE9</accession>
    <name>A0A132PRE9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05520</name>
        <name evidence="3" type="ORF">AWC31_12895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845010.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12895"/>
    <dbReference type="EnsemblBacteria" id="KWX24903">
        <property type="protein sequence ID" value="KWX24903"/>
        <property type="gene ID" value="AFM11_05520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18851">
        <property type="protein sequence ID" value="ORX18851"/>
        <property type="gene ID" value="AWC31_12895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4294"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06355">
        <property type="entry name" value="PBP1_FmdD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017777">
        <property type="entry name" value="ABC_urea-bd_UrtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03407">
        <property type="entry name" value="urea_ABC_UrtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453222" evidence="1">
        <location>
            <begin position="35"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="422" mass="45216" checksum="9AB5306D1BEF5088" modified="2016-06-08" version="1">MRVPARATFRRSALATGSVIAVASLLLAGCGSRASETDAANAESCVDTSGPTIKVGSLNSLSGTMAISEVTVRDSIKLAVDEINAKGGVLGKQIELIGEDGASEPTVFAEKAEKLISSDCVAAVFGGWTSSSRKAMLPVFESANSLLYYPVQYEGLESSKNIFYTGATTNQQIVPALDYLKEKGVKSLYLVGSDYVFPQTANRIIKAYAGANGIEIKGEDYTPLGSTDFSTIVNKVRGANADAVFNTLNGDSNVAFFREYKNVGLTPQDMPVVSVSIAEEEVGGIGVQNVTGQLTAWNYYETIDTPVNKAFVKAYKDFVKDPKKPTSDPMEAAYVSVYLWKNTVEKAQSFDVKAIQDNADGVTFDAPEGKVTIDGENHHITKTARIGEIRPDGLIYTIWESKGPIEPDPYLKSYPWAAGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRG3</accession>
    <name>A0A132PRG3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18390"/>
    <dbReference type="EnsemblBacteria" id="KWX24632">
        <property type="protein sequence ID" value="KWX24632"/>
        <property type="gene ID" value="AFM11_08110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5472"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="133" mass="14635" checksum="C0D9CD54F65FCF79" modified="2016-06-08" version="1">MARTPLHMFGMEYRRDEYLGLIASGEHDVNAQDLDGKTPLHYAAEQEQSEIVHALLDAGADPNIQERIHGNTPLWEAIADIVEPGDPVIVKMIDRGADPTIVNNHGHTPLALARRLGRSCVPLLEATAKNKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRJ3</accession>
    <name>A0A132PRJ3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844977.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24884">
        <property type="protein sequence ID" value="KWX24884"/>
        <property type="gene ID" value="AFM11_05395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4268"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="211" mass="22052" checksum="A7E21D31FEAF2878" modified="2016-06-08" version="1">MRLADVTLRDVLADAWERWGRRCAELTDAQWRTATRCVPWQVEALVAHVCPEPTTFESLAAATVAGPAAVTDAAAMLRIFNEPDGVANTTADQIADRAVSEASALTPRVAAARFAECASRLRQMPEMSRPAQTVIGYPIVGSTTLAVVAEVALMEATVHLLDLADAVGGVEPSPAALAATRDLLIAVPDPVAAVEALAGRRSPAGAVPAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRQ4</accession>
    <name>A0A132PRQ4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="10">PEPC</shortName>
            <shortName evidence="10">PEPCase</shortName>
            <ecNumber evidence="5 10">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ppc</name>
        <name evidence="14" type="ORF">AFM11_06200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="5 10"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845232.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29475"/>
    <dbReference type="EnsemblBacteria" id="KWX25019">
        <property type="protein sequence ID" value="KWX25019"/>
        <property type="gene ID" value="AFM11_06200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4432"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 12">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX25019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="931" mass="102702" checksum="9BBC878E63D0EFB3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRX0</accession>
    <name>A0A132PRX0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845364.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29050"/>
    <dbReference type="EnsemblBacteria" id="KWX25091">
        <property type="protein sequence ID" value="KWX25091"/>
        <property type="gene ID" value="AFM11_06625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4522"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021315">
        <property type="entry name" value="Gap/Sap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11139">
        <property type="entry name" value="SfLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="237" mass="25281" checksum="8750483B68789955" modified="2016-06-08" version="1">MWATVLVMAFAVIFEPIRIGLAVLMLNRPRPLLQLLAFLCGGFTMGVGVGLIVLFVLRSTPLASGRFTVPSVQITVGIVALVIAVALATDISMRRLRRRPARASAGPGPTAYDEDPPRRRNGLSTRMRSILGGDSLWVAWVSGLGTALPSANFMGAMAVILASGEAPIDQAQALLLFNVVAFTLVEIPLIGYIAAPKRTQALLSAFHEWLQNRPRRDMAVVVAAGGCLMLAIGLAHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSA5</accession>
    <name>A0A132PSA5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="5">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_07355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-malate + NAD(+) = CO2 + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845742.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17365"/>
    <dbReference type="EnsemblBacteria" id="KWX25219">
        <property type="protein sequence ID" value="KWX25219"/>
        <property type="gene ID" value="AFM11_07355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4671"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="7">
        <location>
            <begin position="5"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="350" mass="37538" checksum="F9855DECDF904380" modified="2016-06-08" version="1">MARQRIAVIPGDGIGGEVIESARAVLDAVSTRHSTDLEFTEFDWSCQRYERTGAMMPADAIDTLRDFDAILLGAVGWPGVPDHVSLWGLLIPIRRAFRQYVNLRPIRVFTGVSSPLRNATDVDFVVVRENVEGEYSEIGGRLNRGFPEEMAVQESVFTRAGVSRIADYALELAKTRRGYVTSATKSNGIVHTLPFWDEVVAERAAIHPDVRVDSEHIDALAAKFVLQPERFDVVVGSNLFGDILSDLAAAVAGSIGIAPSANLDPTKHYPSMFEPVHGSAPDIAGKGIANPVGAVWSAAMMLEHLGHTSAADDVLVAMEATLANADTRTADLGGHASTTEVTDALIAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSE7</accession>
    <name>A0A132PSE7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_07205</name>
        <name evidence="8" type="ORF">AWC31_17510</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845667.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17510"/>
    <dbReference type="EnsemblBacteria" id="KWX25194">
        <property type="protein sequence ID" value="KWX25194"/>
        <property type="gene ID" value="AFM11_07205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17494">
        <property type="protein sequence ID" value="ORX17494"/>
        <property type="gene ID" value="AWC31_17510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4641"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041193">
        <property type="entry name" value="CysA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17850">
        <property type="entry name" value="CysA_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX17494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="371" mass="39817" checksum="33EAF8ECA45BD084" modified="2016-06-08" version="1">MATVSIAGVRKSFGKTKAVDGLSVDIADGEFFVILGPSGAGKTTTLKSVAGLVDIDEGSVHIGGTDVTRVEPYHRNVAMAFESYALYPQKTVAENLASPLKSGRTGRYTEAQRAERIDQVTTTLGINHLQKRFPRELSNGQRQRVALGRVLVRPADIYLLDEPLSHLDAKLRAAMRAELKQLGAMSNTTTIYVTHDYQEALALGDRIAVMREGKLVQIGTPDEIWRRPADTFVAKALGQPEINLLDGVVDDGQIRLGDGSLDIAVPAGVECDRGDRVRVGLRPCDLHVTSGESSLRGRVLLAERLGRNIELTVDIGGTQLIALTSGRHGVGEGDDVRLKVAESDIHVFAAGSGDTPRLGRAQSDSPLEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSJ8</accession>
    <name>A0A132PSJ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843912.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21825"/>
    <dbReference type="EnsemblBacteria" id="KWX25319">
        <property type="protein sequence ID" value="KWX25319"/>
        <property type="gene ID" value="AFM11_03260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2527"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023027">
        <property type="entry name" value="Mannitol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00974">
        <property type="entry name" value="MANNITOL_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="1">
        <location>
            <begin position="36"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="2">
        <location>
            <begin position="210"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="478" mass="52411" checksum="480788E1D832CFE9" modified="2016-06-08" version="1">MRIVTYTTPPVKLAASTLKELPIPGPSYNRDEIQVGIVHFGVGGFHRAHQATYVDQLLEQGLASDWGICGVGVLPSDRKMADVMAAQDGLYTLLLVHPDGKREARVIGSIVDYRFAPDDPDGVIELLASPSTRIVSLTITEGGYDIEAVPELNVFGLVTEALSRRRDRGLGAPTIVSCDNIEGNGEVARQAFTTYADRRHPGLGDWIAANVRFPNSMVDRITPVTTPDVIATVESEFGVADQWPVVAEPFTSWVLEDSFSDGRPPYEDAGVMLVDDVTPYELMKLRLLNASHQALCYFGYLAGYRLVHDAASDPLFAEFLLAYMDSEATPTLQPVPGIDLGDYKRTLIERFANPGVRDTIARLCFGSSDRIPKWLLPVVRENLKTGAPVRLSAAVVASWARYAEGVDEQGEPIDVQDQLAETLVPLARSQREHPTAFIENTALFGDLAAAPRFVDDYLWALDSLHRHGARATLESLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSQ5</accession>
    <name>A0A132PSQ5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase (ATP)</fullName>
            <ecNumber evidence="2">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">NHEJ DNA polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFM11_03290</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843940.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21795"/>
    <dbReference type="EnsemblBacteria" id="KWX25325">
        <property type="protein sequence ID" value="KWX25325"/>
        <property type="gene ID" value="AFM11_03290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2533"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04863">
        <property type="entry name" value="MtLigD_Pol_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033649">
        <property type="entry name" value="MtLigD_Pol-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="540"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="725"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KWX25325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="753" mass="84068" checksum="BCEED684608748FE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-12-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTR6</accession>
    <name>A0A132PTR6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_04960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844690.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25587">
        <property type="protein sequence ID" value="KWX25587"/>
        <property type="gene ID" value="AFM11_04960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2873"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="176" mass="18968" checksum="26DEED1AC75CDAFC" modified="2016-06-08" version="1">MARAVAGAGLVGMVVVITMQVLYRYFLDQSLAWTEEVSRFLFILTSFIAITVAHRRQMHAGYSSLVTKFPVAVRRVVIIGVDVVSIVFFVVVGLSSRNLIDIGFDSAAPATGMPMAWIYLVFPIFAVLGVVFSVEHIVLHLSADAEGLLSADEDRAVAAEAEGAIGDTPNHERSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU38</accession>
    <name>A0A132PU38_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842414.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33810"/>
    <dbReference type="EnsemblBacteria" id="KWX25859">
        <property type="protein sequence ID" value="KWX25859"/>
        <property type="gene ID" value="AFM11_00770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.158"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="283" mass="30220" checksum="ED275EED31823C72" modified="2016-06-08" version="1">MTQTTAQPTKPDLGKYGSFGRGVTPAQAKDIEALGYGAVWVGGSPPAELEWVEPILEATTTLQVATGIVNIWTADAGPVSESFHRIESAYPGRFLLGIGVGHREAIGEYRKPLDALTDYLNKLDEYGVPKHRRVVAALGPKVLQLSAERSAGAHPYLTTPEHTAQAREVLGPDAFLAPEHKAVLTTDADKARTVGRKALDIYLGLTNYLNNFKRLGFTDEDLAKPGSDRFIDAVVAYGTVEAVAARLKEHLDAGADHVPVQVLTSPEKLVPALAELAGPLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU60</accession>
    <name>A0A132PU60_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_00740</name>
        <name evidence="7" type="ORF">AWC31_33780</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842396.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25853">
        <property type="protein sequence ID" value="KWX25853"/>
        <property type="gene ID" value="AFM11_00740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11654">
        <property type="protein sequence ID" value="ORX11654"/>
        <property type="gene ID" value="AWC31_33780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.152"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX11654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="222" mass="25104" checksum="CB79BC227C013C0C" modified="2016-06-08" version="1">MRVTGAMRKRNREIGNYGGVGRPNRQAERREEILDAAIALIERHDLATLRIADVAAELGLTANAVRYYFKEMDQLLSELAQRSDTRFYDERLAVVDRTEDVREQLALTIAAGLPTGPEDAEWRAIWRAVLAAGFELDQRRDVQHIYHRQVKLYTRILESGAQSGVFRLGSPARDIAMTLMAMEDYLGYRIVARDPELSRETALRLQRGYAELATGATLPVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUD8</accession>
    <name>A0A132PUD8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 7">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_01155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + L-glutamate = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 7"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842622.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34195"/>
    <dbReference type="EnsemblBacteria" id="KWX25925">
        <property type="protein sequence ID" value="KWX25925"/>
        <property type="gene ID" value="AFM11_01155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.237"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="PTHR43321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="464" mass="51456" checksum="2AE685BD2C76A784" modified="2016-06-08" version="1">MSHKHTRAPHVSPAYTGRLAMAPVPSLRLPDEAMDPAAAYRFIHDELMLDGSSRLNLATFVTTWMDPEAEKLMAETFDKNMIDKDEYPATAAIEARCVSMVADLFHAEDLRDDDPASAVGVSTIGSSEAVMLAGLAMKWRWRAKVGGEKGDAWKGRTPNLVMGANVQVVWEKFCRYFDVEPRYLPMAEGRYVITPEQVLEAVDEDTIGVVAILGTTYTGELEPIAEICAALDKLAEDGGHDVPVHVDAASGGFVVPFIHPDLEWDFRLPRVVSINVSGHKYGLTYPGIGFVVWRNKEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRLGRAGYTQVMQCLSQTARWLGDELRDSEHFELITDGSAIPVVSFRLKGNPGYTEFDVSQALRAYGWQVPAYTMPEGATDVVVLRVVVREGFSADLARALKDDTITVLKHLDELKPGGQFDEVQPFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUW2</accession>
    <name>A0A132PUW2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metabolite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_02365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843227.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26105">
        <property type="protein sequence ID" value="KWX26105"/>
        <property type="gene ID" value="AFM11_02365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.485"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="19"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX26105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="471" mass="49671" checksum="B16F988B8BB4DF4E" modified="2016-06-08" version="1">MSSLDVMDLPARRGFHAKLLTACCGGPFLDGYVMSIIGVAMLGVTAELNPSTAESGLIGAASLIGIFFGATVFGFLTDRLGREKMYALDLVVLVVACGLCVFVQAPWQLIVLRFVIGAAIGADYPIATSLLTEFTPSKKRGAMIGMSAVAWSAGAVFAYIVGAFFVGFTGGNDHWRLLLATSAVLGVIVIIMRRGIPESPRWLLQHGRVADAEAVVKKIYGTAVDLSSVAVDDPDANPLKPRANLGVFFRGQYMRRLVMCSVLYLAVVTPLYALLTFLPAILSGFAISGEGPMGLIVETVIIGLIVAGSIPALYLVERWGRRPIAVVPLGLMVLPLAGLWLWADGPLWFIVAAFCVYTFISGGPSILVWIYPNELFPTEFRATAVGIATAVSRFGAATGTYLLPLSISSLGTGTTMLFGAVLTAVAFVVCFFMSPETKGKSLEEVSELPSAAATAVSPTAPGPDGAMARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV19</accession>
    <name>A0A132PV19_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_02900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843506.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35680"/>
    <dbReference type="EnsemblBacteria" id="KWX26191">
        <property type="protein sequence ID" value="KWX26191"/>
        <property type="gene ID" value="AFM11_02900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.597"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="17"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="411" mass="43800" checksum="E58A1DF0750560AE" modified="2016-06-08" version="1">MTVRITIIGINYAPEVTGIAPYTTGLAEGLAARGHDITVITGLPHYPEWRIADAYANAPRSSVEMVNGVTIRRVRHAMPETPSTKGRVRMEASFALAAARSGWNRPDVVLTVSPPLLASCAVVGRARAQRIPVGVVVQDLYGKGVVETSAMGGRGAAATTKLEVGMLSSATGVSVIHDRFADVLSELGVDRGRITVVRNWTHIEIPTEDPDSTQNVRAKYGWDPDEVVVVHAGNMGAKQGLENVVAAAKLVDRSESPVRFVLLGDGNQRRKLEEAAVGAKSLQFIRPVPADEFTKVLKAADVLLVNEKPDVADMAVPSKLTSYFVSGRPVVAATSDGSATAYEVRSSGAGVIVPADDPETLVSAAHRIGADKEAGLQMGQSGQRYAKDVLDESAAIDRYERWCSDLVARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVB1</accession>
    <name>A0A132PVB1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_00600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33715"/>
    <dbReference type="EnsemblBacteria" id="KWX26214">
        <property type="protein sequence ID" value="KWX26214"/>
        <property type="gene ID" value="AFM11_00600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.123"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="4"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="497" mass="54016" checksum="2C301E5DA6383F49" modified="2016-06-08" version="1">MNPDVLVVGAGPTGLTLACSLRLHGLSVRVVDRAPGPATTSRANFLHARGSEVLNRIGALGTLPDESLRAMRITNYLGDRPVMTLEFGDPGMRTASPPMVVSQAKVEAALRARLAELGVTPEWGLPLRAAHQDTDMVVAEVGDGEVIRARWLVGCDGTSSTTRELTGIDFPGVKLGERFLLADIHLDWDLDRAGTSGWIHPDGVVGAMPMPSSGTDNLWRLFVYDPTLREKPSETDILERIKQILPQRTGRRVQIGDAEWLSVFTVHRRLADTYRRGRILIAGDAAHAHAPFGGQGMLTGIGDAENLAFKLALVVRDRASDALVDTYEAERRPLATEVLRGTSAVTRVNVADNPVGRFVRDHVATRIFGLAVVQRWTTYTASQLWVSYRKGPLGGRGRKPRPGDRIPDSACSRADGTSTTLHSELGGRWALLVPTGTPGVVDAVHRRLGDFVVVLFHGGDQMMLIRPDAHLAWRGRPDDVDGLDHWLCAALRSGNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAR9</accession>
    <name>A0A132PAR9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_35960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000058">
        <property type="protein sequence ID" value="KWX19421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019344575.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19421">
        <property type="protein sequence ID" value="KWX19421"/>
        <property type="gene ID" value="AFM11_35960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6271"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="437" mass="48109" checksum="EEDAAF906B7DB5E0" modified="2016-06-08" version="1">MLTVVDNNDDSNETRNAAGAGRSLLDQIVRDGARQMLAAALQAEVADYVARYAGEVDEHGHRLVVRNGYHAEREVVTSAGAVAVKAPRVNDKRIDPDTGERKRFSSAILPAWARKSEQVSEVLPLLYLHGLSTSDFGPALEQFLGTGAGLSASSITRLTAQWQDEAKAFGTRDLSQVDYVYLWVDGIHLKVRLEQEKLCLLVMLGVRADGRKELVALADGYRESTESWADLLRDCRRRGMRAPALAVGDGALGFWRALREVFPATREQRCWFHKQANVLAALPKSAHPGALAAMKEIIGAEDIDKAQLAIAAFERDYSAKYPKAVKKIVDDADVLLEYFRYPAEHWVHLRTTNPIESTFATVRLRTRVTKGPGSRAAGMAMAYKLIEAAQSRWRAVNAPHLVALVRAGAVFHQGKLLERPVDITPEPSPDTPVSEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAX8</accession>
    <name>A0A132PAX8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal biosynthesis lyase PdxS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000047">
        <property type="protein sequence ID" value="KWX19466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19466">
        <property type="protein sequence ID" value="KWX19466"/>
        <property type="gene ID" value="AFM11_35745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="4">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="79" mass="8185" checksum="E636D73FC2DD9D11" modified="2016-06-08" version="1" fragment="single">METAAQNGSNNQTGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAVAVMALERVPADIRAQGGVSRMSDPDMIEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB02</accession>
    <name>A0A132PB02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000044">
        <property type="protein sequence ID" value="KWX19511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040843.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19511">
        <property type="protein sequence ID" value="KWX19511"/>
        <property type="gene ID" value="AFM11_35485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5831"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="70"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="249" mass="26466" checksum="B11BE40136B5DD07" modified="2016-06-08" version="1">MAGNTSTPGTSVASRLLRMVAAFDEWHRTLTLSELAGRASLPMATAHRLAAELVAGGALQRRTDGRFEVGRLMWSAGLLAPVGGGLRQVAEPFLHDVYAATLATVHLAVRDGNEVLYLERMMGRASVPIVSTVGSRLPMHCTGVGKVLLAHAPREVQDQVFANLTPITPYTITQPAVLSRQLEGVRREGLATTVEEMSLGACSLAVPIVRQSDDAVVAAIAVVVPSLKRGRQRLLGALQVAARGIVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB21</accession>
    <name>A0A132PB21_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urease accessory protein UreE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35595</name>
        <name evidence="3" type="ORF">AWC31_02655</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02655"/>
    <dbReference type="EnsemblBacteria" id="KWX19494">
        <property type="protein sequence ID" value="KWX19494"/>
        <property type="gene ID" value="AFM11_35595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11057">
        <property type="protein sequence ID" value="ORX11057"/>
        <property type="gene ID" value="AWC31_02655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5855"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02814">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE_N" evidence="1">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="153" mass="16687" checksum="7B33718C2514584D" modified="2016-06-08" version="1">MTAVADGPRILDGIVGWATDDAVAGRLHELRHHQAVEYVHLDAHDLDRRRLRVTSDAGTDYAVILTRDSTLGDGAVLLLEADRAVVVRAGAPQTLTLRVHDLAAALRLGFLAGHLHWKVDQHDDTLVVHAEGPRSDYTARITELLATGRVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB82</accession>
    <name>A0A132PB82_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859657.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19570">
        <property type="protein sequence ID" value="KWX19570"/>
        <property type="gene ID" value="AFM11_35110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5750"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="326" mass="34038" checksum="4B065479924FC560" modified="2016-06-08" version="1">MPKISNVWKRRLTMGSRGAGRIILGILVVTSSISGANTVWGWVFPDPPPPIAAIADKTINASDLVKSFAIDCVTTYLTASSALGTDLARCFPNASKLTVPSTPSMIVSNPSAYARRHGPDRANLRTYGVLVGVTTQAYPSASPARLYYQIPVGVYGGDAVRALDNLAYVDEPPTGVDVELGYPANIPSTQPVAVMLAGFISAYLSNSPCIGGTSEGTETPCRPTGSLDRYITTDSGLKPVKNPYASATVTAVQAIANPPDAPQDNATLSVRVTVSARSTDYTPYDLSYPLTIRATGGSWFVAGLEAVPALADSEPQPPTANATGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBG4</accession>
    <name>A0A132PBG4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22195"/>
    <dbReference type="EnsemblBacteria" id="KWX19671">
        <property type="protein sequence ID" value="KWX19671"/>
        <property type="gene ID" value="AFM11_34625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5272"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="221" mass="23864" checksum="CEB3F399449A2338" modified="2016-06-08" version="1">MTTSTSSTTDHLTDPRPILNRAIATCGGVIAGVRPEQLTDPTPCTDMDVRALLAHLIGVLGRIAALGNGDDPFAVTDTPVADDRWLDAWRESGSRVADAWSDDAVLERPMALPWIQGSGAKVLASYFSELTVHTWDLATATGQQPDWDDTVVAAAFDAARQILPAENRRALYEEISAARGFDEVAVPFAEAVPISDDAPVIDRLVAWNGRDPRGRSWRSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBI4</accession>
    <name>A0A132PBI4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859427.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17275"/>
    <dbReference type="EnsemblBacteria" id="KWX19689">
        <property type="protein sequence ID" value="KWX19689"/>
        <property type="gene ID" value="AFM11_34520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5249"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="288"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="382" mass="40180" checksum="7304FB93D40F3050" modified="2016-06-08" version="1">MTVTIVGAGIGGLTLARVLTVHGIACTVYEAEPSIGSRTQGGQLDIHAETGQVALDAAELTAEFRAIIHEGAEAARILDRHGTVLFEQADDGAGSRPEVLRGDLRRLLLASLPDGTVSWGRKLAGARALDGGRHELTFADGHTVATDLLVGADGAWSRVRRLVSDAVPSYIGTTFVETYLHDADVRHPLAAKAVGAGALYALAPGIGITAHREPRAVLHGYLELNRPLEWVAGIDFTDPSAAIASVAREYAGWAPELTALLIEADEGPVARPLYALPDGHRWDHVPGVTLIGDAAHLSPPGGEGANLAMLDGARLALAIATHPDDADTAFAVYEQEMFPRSAASAVDARETLDLCLGARAPYGLVDFFADEQGLAQDSRRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBM9</accession>
    <name>A0A132PBM9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859146.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19704">
        <property type="protein sequence ID" value="KWX19704"/>
        <property type="gene ID" value="AFM11_34225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5184"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453143" evidence="1">
        <location>
            <begin position="30"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="215" mass="22657" checksum="6D48C63DDB584328" modified="2016-06-08" version="1">MGGKLAARGTGRWLALVASVIVAASMFYAQGTDSSQSAQTPAAVLPTPSMPTGAAPAEAELVAASAPVAARDFQLALPPGVAPESGLQIKTIWAARAISVMFPEITTIGGYRQDPLKWHPNGLAIDVMIPDYHSDEGIALGNQIAGFALANAKRWGVLHVIWRQGYYPGIGAPSWTADYGSETLNHFDHVHIATDGGGYPTGEETYYIGSLKRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBY2</accession>
    <name>A0A132PBY2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858981.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32505"/>
    <dbReference type="EnsemblBacteria" id="KWX19757">
        <property type="protein sequence ID" value="KWX19757"/>
        <property type="gene ID" value="AFM11_33945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5126"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="216" mass="23594" checksum="C725B4CEF28FBA00" modified="2016-06-08" version="1">MTLSVTTDKDTDKDTELDDKEVEETADDVDEPSEEVDSTDEKADPAEESDDKQVTERRSPRKVLIGAVGAVLIAVLAGAGYLGWQLWQQQQVERAGQAAQQAAAAYAAVLTSIDTAKVDENFTQVLDGATGEFKDMYSKSATELRQLLIDNKASAHGVVLESAVQSATKDKVVVLLFVDQSVSNTHVPDPRIDRSRIKMTMENVDGRWRASKVELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBY6</accession>
    <name>A0A132PBY6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33775</name>
        <name evidence="2" type="ORF">AWC31_07980</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858873.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07980"/>
    <dbReference type="EnsemblBacteria" id="KWX19826">
        <property type="protein sequence ID" value="KWX19826"/>
        <property type="gene ID" value="AFM11_33775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10347">
        <property type="protein sequence ID" value="ORX10347"/>
        <property type="gene ID" value="AWC31_07980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5092"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="103" mass="11205" checksum="DC0F25A30DDD6450" modified="2016-06-08" version="1">MTLAADRHLGDQKFAIEDISTGVHASGFGQVGDGRTFSFHIERQQLMIEVYRPRLSGPVPAEEDVVAVAARKLTDIDLTDERSLSATVRDAVAEAQPVARTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC79</accession>
    <name>A0A132PC79_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxy-2-oxovalerate aldolase</fullName>
            <shortName evidence="7">HOA</shortName>
            <ecNumber evidence="7">4.1.3.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-keto-pentanoic acid aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">4-hydroxy-2-oxopentanoate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_33070</name>
        <name evidence="10" type="ORF">AWC31_17155</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:36003"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17153"/>
            <dbReference type="ChEBI" id="CHEBI:73142"/>
            <dbReference type="EC" id="4.1.3.43"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36004"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22624"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:73143"/>
            <dbReference type="EC" id="4.1.3.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 4-hydroxy-2-oxovalerate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.39" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858477.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17155"/>
    <dbReference type="EnsemblBacteria" id="KWX19928">
        <property type="protein sequence ID" value="KWX19928"/>
        <property type="gene ID" value="AFM11_33070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18118">
        <property type="protein sequence ID" value="ORX18118"/>
        <property type="gene ID" value="AWC31_17155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4946"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008701">
        <property type="term" value="F:4-hydroxy-2-oxovalerate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07943">
        <property type="entry name" value="DRE_TIM_HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01656">
        <property type="entry name" value="HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017629">
        <property type="entry name" value="4OH_2_O-val_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012425">
        <property type="entry name" value="DmpG_comm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035685">
        <property type="entry name" value="DRE_TIM_HOA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07836">
        <property type="entry name" value="DmpG_comm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03217">
        <property type="entry name" value="4OH_2_O_val_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX19928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX18118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="351" mass="37408" checksum="8268D292203A5A9B" modified="2016-06-08" version="1">MTTKDIFFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVGAIVAALDTAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIAFLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMSHTISPEKLAAQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMGYSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEIKREQDAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC97</accession>
    <name>A0A132PC97_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858545.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17040"/>
    <dbReference type="EnsemblBacteria" id="KWX19949">
        <property type="protein sequence ID" value="KWX19949"/>
        <property type="gene ID" value="AFM11_33185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4969"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="356" mass="36464" checksum="BA451B7006E25726" modified="2016-06-08" version="1">MGKLKTPLTELVGIEHPVVQTGMGWVAGARLVAATSNAGGLGILASATMTLEELQTAVSKVKAATDKPFGINIRADAGDANERVDLLIREGVKVASFALAPKPELIAKLKDAGVVVIPSVGAAKHAKKVAGWGADAVIVQGGEGGGHTGPVATTLLLPSVLDAVATTGMPVVAAGGFFDGRGLAAALSYGAAGVAMGTRFLLTSDSTVPEAVKQRYLQAALDGTVVSTRVDGMPHRVLRTGLVEKLESGSRARGFTAAVLNAQKFKKMSGMTWRSMIKDGMAMRHGKELTWSQVVMAANTPMLLKAGLVEGNTDAGVLASGQVAGIIDDLPSCAELIENIVADAVERLQAAAALVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCC1</accession>
    <name>A0A132PCC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858285.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32135"/>
    <dbReference type="EnsemblBacteria" id="KWX19985">
        <property type="protein sequence ID" value="KWX19985"/>
        <property type="gene ID" value="AFM11_32760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4881"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008526">
        <property type="entry name" value="YedI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30503">
        <property type="entry name" value="PTHR30503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05661">
        <property type="entry name" value="DUF808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016660">
        <property type="entry name" value="YedI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="317" mass="33220" checksum="D2BDE2EF06C56377" modified="2016-06-08" version="1">MSAGLFGLLDDVAALARLAAASVDDIGAAAGRATAKAAGVVIDDTAVTPQYVHGITADRELPIIKRIAIGSLRNKIVFILPAALLLSQFAPMLLTPILMLGATYLCYEGAEKVWGWITGHDAHAAPAATEGPDAEKFMVTGAIRTDFILSAEIMVIALNEVADQPFLPRLVILVVVALVITAAVYGVVAGIVKMDDIGLSLTQRKSRFGQKIGRGLVAGMPKLLSALSIIGTIAMLWVGGHILLVGTDTLGWHTLYGIVHHAEEWVHHAVPGVGAVLAWLTNTAASAVIGLVVGAVVVAIMHVLPFGKKKQQHETHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCJ8</accession>
    <name>A0A132PCJ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858067.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19520"/>
    <dbReference type="EnsemblBacteria" id="KWX20065">
        <property type="protein sequence ID" value="KWX20065"/>
        <property type="gene ID" value="AFM11_32395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4807"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019910">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_4879"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03564">
        <property type="entry name" value="F420_MSMEG_4879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="318" mass="34066" checksum="4BA758C3E14F4C23" modified="2016-06-08" version="1">MRLGVMIGAERGDMARKVNKLAADIQWAEAAGLDSAWMPQVPDDFDALTMVTLMAAHTSTIELGTAVVPLQAQHPIALARQALSVHAVTEGRLALGVGPSHHWIIRDMLGLPYEKPAAYTRDYLEVLNAALAGPGPVDVENDTFTVHNPTALAAQTPMPVLVAALGPVMLQIAGELADGTVLWMADEKAIGEHIAPKITKAAADAGRRAPRIVAGIPVCLCANSEIDAAKERANRILAEAETSPNYQRLLDRGDARNVGDLCAAGDAETILRQFRRFADAGVTDLSVRLLPIGDNRDELIASKYRTREVIAELAKQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCS1</accession>
    <name>A0A132PCS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20133">
        <property type="protein sequence ID" value="KWX20133"/>
        <property type="gene ID" value="AFM11_31800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4687"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="508" mass="53871" checksum="934C2E06FC94F1EB" modified="2016-06-08" version="1">MDMINFIPNDPLVVDVIPMRRVAARPDRGAGTAGITVASNAAEGTFDPGHPDFVAWQARQAAILAVEAWEEVLGEPLTSWAQEAVNPAALMLIPDAGEEVNAYYDRESLSFFHASNGRGTTFTGASTDVVAHEVGHGVLDALRPDLWFVNLLEVGSFHEAFGDITSILTALRDEPTRRALLDVSPDLSEPNFVEAITEDLADTARHLFGANFSAAKPRRALNTFKWQLPQTMPQSSGPDVMIAEVHSLGRIISGCFYDVLRGIFVAGDRQTAAGLWKATKTTAALVYEAARTAPAVPRFFRAFGRAMVLADNTLNDGAHSQIIGKAFFDHGIALGAQAFLAPELPLAGGSPTLSPEGVSLERATISDLRRRVGAGARAAARVSLVELGGATMANVTIHDEVALDEVDKRLRGVVAGVDSVALVGDSGGAAALMTAPRAGAASSEVLDFVGSLVKHDQVDFGAAPAAKKRAVKAPDKSATVTTHAVRKRGRKQELQRVRFACGAARSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDC3</accession>
    <name>A0A132PDC3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_30715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857101.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26435"/>
    <dbReference type="EnsemblBacteria" id="KWX20329">
        <property type="protein sequence ID" value="KWX20329"/>
        <property type="gene ID" value="AFM11_30715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4045"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="7">
        <location>
            <begin position="37"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="495" mass="53171" checksum="9371B6BAE154DA00" modified="2016-06-08" version="1">MSAIEERTAVGSRPTGLGGLLAVQREAFIADGPPDVALRRNRIDRLMAMILENCEDFVSATASDYGSRSKSAAFFAEILGMISVIEHTRSNVPQWIRSTRLMRAARLARLRAEVVPSPLGVVGIIGPWNFPVQLTVLPAAAAFAAGNRVMIKMSEVTPNTAELMAATAPRYFDERELAIITGGADVAAEFAGLPFDHIFFTGSPAIGALVQQAAARNLVPVTLELGGKNPVVVAPGADIARAASRIAQGRMVNGGQVCVCPDYVFVPDARVDQFVDVARRTLSSMFPTIVDNGDYCSSVNQANFDRIVGLISDARAHGARIDSVVPAGETLPDPVSRKIAPTIIRDVDDRMRIAEEEVFGPVLAVRGYSALTDAIDYINARPSPLVAYWFGPDDDDFRRFVARTRSGGVARNDFAAHMIPSSAPFGGVGRSGMGAYHGKAGFDAFSHYRTVVGSDLPFSITARAAQPFTASMRVSADLALRRARSRTSSRLKKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-02-10" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDJ4</accession>
    <name>A0A132PDJ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_31470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20307">
        <property type="protein sequence ID" value="KWX20307"/>
        <property type="gene ID" value="AFM11_31470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4199"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="459" mass="47972" checksum="5F77ECC9AD47E5B1" modified="2016-06-08" version="1">MAMVASACGTSTPERVDPFTVAGMRVTDGPSGLRAGAPKPSRTVTNSDSGPIDLLAAQSVSDVEEYWKGAFRDAFGTGFTPVRKLVSWDAEKPGSTAPFCGETTSGLVNAAFCPVDSTIGWDRGVLLPSLRKAYGEMAVAMVLAHEYGHAVQYQADLNPANTPTLVAEQQADCFAGAYMRWVAEGNSARFTLSSGNGLNAILASVISFRDPLFNRNRASSGGEHGSAFERVSAFQFGFTDGPETCKGIDEKEVTQRRGDLPVALQRGQTGDWPVSPASVRSVIAAMNILFQPANPPRLTFDPGAAAKCPDADSKPPASFCPATNIIAVDLAGLKKLGTAREGVSGLTGDNTAYSVLISRYMLAVQHELGLPLDSAETGLRTACLTGVATRKLTNQVSTPDGNTVALTAGDLDEAVTGLLVNGLAASDINGQSAPAGFARIDAFRTGVLSDQDHCVESFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE13</accession>
    <name>A0A132PE13_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32090</name>
        <name evidence="3" type="ORF">AWC31_31760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857885.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31760"/>
    <dbReference type="EnsemblBacteria" id="KWX20212">
        <property type="protein sequence ID" value="KWX20212"/>
        <property type="gene ID" value="AFM11_32090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12708">
        <property type="protein sequence ID" value="ORX12708"/>
        <property type="gene ID" value="AWC31_31760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4744"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX12708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="124" mass="14232" checksum="2150F7C48F34693D" modified="2016-06-08" version="1">MGIKGFGDLEAVVMDVLWSRSEPSTVRSVHDELVTQRQIAYTTVMSTMDNLFRKGWLLRDKVGLAYQYRPVMSREEHSAKLMRTVFESGGDSELILNFFLEQIADDDSVKLRQALQRFSKGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE33</accession>
    <name>A0A132PE33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_30420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20487">
        <property type="protein sequence ID" value="KWX20487"/>
        <property type="gene ID" value="AFM11_30420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3984"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452989" evidence="9">
        <location>
            <begin position="23"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="10">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="11">
        <location>
            <begin position="307"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX20487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="641" mass="66165" checksum="B60B394510510DC1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEM2</accession>
    <name>A0A132PEM2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32800"/>
    <dbReference type="EnsemblBacteria" id="KWX20788">
        <property type="protein sequence ID" value="KWX20788"/>
        <property type="gene ID" value="AFM11_28545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3587"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="553" mass="61125" checksum="F9D9E3021F330949" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEY1</accession>
    <name>A0A132PEY1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20890">
        <property type="protein sequence ID" value="KWX20890"/>
        <property type="gene ID" value="AFM11_27750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="107" mass="10952" checksum="27A5219222437A18" modified="2016-06-08" version="1">MAQSATGAGCVVDTAGELVRSGVPALAGGALTVGATGGWASGVPAEHPARAVAAISEARPMPAWRIIVFIEYSWCPRIAVRRPSACVQVNRVATATDPKSDDPYGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF68</accession>
    <name>A0A132PF68_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminoglycoside resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856007.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10485"/>
    <dbReference type="EnsemblBacteria" id="KWX20989">
        <property type="protein sequence ID" value="KWX20989"/>
        <property type="gene ID" value="AFM11_27965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3467"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006748">
        <property type="entry name" value="NH2Glyco/OHUrea_AB-resist_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04655">
        <property type="entry name" value="APH_6_hur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="297" mass="33518" checksum="2B559FB0649808BD" modified="2016-06-08" version="1">MIELPDAVRAMSARGPRWQAWVDGLPKLVRAQIAEWELTPDGPPTHGYCSIVVPARTRDGDTAVLKVGFPDEESEHEHLALRRWAGQGAVRLLRAEPHRRAILIERLHSRNLNELWDIEACEVVASIYARIHVPALPQLRSLTEYVHRWTTQLQALPRNAPVPRRLVEQAIGLGTDLAAEPASAATLIHGDLHYENVLAADREPWLAIDPKPLNGDPHYELAPMLWNRWDELTGYVRDGVRRRFYALAEAAGLDADRARAWVIVRVMHNAMWELTENVEPDADWLTTCVAIAKAVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG46</accession>
    <name>A0A132PG46_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl transferase family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_28255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10805"/>
    <dbReference type="EnsemblBacteria" id="KWX20962">
        <property type="protein sequence ID" value="KWX20962"/>
        <property type="gene ID" value="AFM11_28255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3525"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="63"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX20962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="484" mass="52012" checksum="3695BC7FB39D211C" modified="2016-06-08" version="1">MADLRVDESTRPTPVFAAASILPIAALTALAHCAAALLGTGYWFDEVYMLAAGRHHLDWGSADQPPVTPALAALLDAAAPGSVFAMRLPAVVATAGAVVLAGLIARELGGDRRAQTLTAAAQATALWTTLTGHWLTPYTLEPMQWLLIVWLLVRWIRVRHDRLLPACGVAVGVAAMTKFQVVLLCAVLLVCVAVLGPRELLRRPALWAGALIAAVIAAPTLLWQHAHGWPQLQMITVVAGEADALYAGRAGIAVQLIVYAGVLGVVLGGYGAWQLLRVAQLRDYRFLLATAVLLYVLFVVTQGRPYYLAGLYAPIAAAGAIGLQRRRESGQPRRRWLGRSVVGLAVATAVAILVLSVQITRSDVGEQIARETAQAYRALAGHQRDHTAVMGESYIVAAYLDGYATTYGLPAAYSPNRSYGYFDPPPDSVDSVLYVGSEPDAVRPYFTTVRTVGAVGDDMHIYLLTGRQQPWQSIWPRLRSLTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG54</accession>
    <name>A0A132PG54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-carboxy-cis,cis-muconate cycloisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854503.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21328">
        <property type="protein sequence ID" value="KWX21328"/>
        <property type="gene ID" value="AFM11_25735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3011"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="1">
        <location>
            <begin position="84"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="398" mass="41477" checksum="B982548EFFB870CF" modified="2016-06-08" version="1">MSDLFWPGDHRAGDVMSTAAFLDALVAAENAWLAALVDSGIAPRAAAADLRALIRPGDLDEIAAGAERDGNPVTGLVALLRSRADGEASQWLHRGLTSQDVLDTALVLCLRDAMKTITDDIGRQLHALVELTEKHRGTPMLTRTLTQPALPGTAGRKFSVWLTAVLDAAEGLKALPPLPVASGGAAGTFAATTELAGSPEAALALARRWADGLGLAAAHPWHTTRSVITRAGDALVGCCDAWGHLANDIAAATRTGELYEESGGGSSTMPHKNNPVLTVLLRRAALTAPPLGATLHAASAASVDERSDGGWHAEWATLATLTRRTVVAASEAADLLAGLRVGTDRAAANLAAAQDIRAEQQKMAELTGRKPAPGYLGATDLLIDTALERARHYLKDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGA7</accession>
    <name>A0A132PGA7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855073.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22605"/>
    <dbReference type="EnsemblBacteria" id="KWX21247">
        <property type="protein sequence ID" value="KWX21247"/>
        <property type="gene ID" value="AFM11_26730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3217"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="313" mass="33749" checksum="025B24704CC6C8A1" modified="2016-06-08" version="1">MSEEAQPVAGPPKNLAAGLVKAVRPRQWVKNLLVLAAPLAAVGSGIQYDYGDLAVKVSIAFVVFCLAASSIYLVNDARDVEADRAHPTKRFRPIAAGVVPEWMAYTLAVLLAAASLIISWLLTPDLAVVMAVYLIIQLAYCFGLKHQAVLDICIVSSGFLIRAIAGGVAADIGLSQWFLLVMAFGSLFMAAGKRYAELQLSERTGAKIRKSLERYTSSYLRFVWTLSATAVVVSYGLWAFGRDSASDPLGIDGQDASWYAVTIVPWTIAILRYAVDIDGGIAGEPEEIALKDRVLQILFLAWIGTIGAAIYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGK9</accession>
    <name>A0A132PGK9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvC</name>
        <name evidence="12" type="ORF">AFM11_24820</name>
        <name evidence="13" type="ORF">AWC31_27075</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854021.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27075"/>
    <dbReference type="EnsemblBacteria" id="KWX21443">
        <property type="protein sequence ID" value="KWX21443"/>
        <property type="gene ID" value="AFM11_24820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14822">
        <property type="protein sequence ID" value="ORX14822"/>
        <property type="gene ID" value="AWC31_27075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2325"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="184"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX21443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX14822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="337" mass="36493" checksum="2D605D6174977996" modified="2016-06-08" version="1">MAVEMFYDDDADLSIIQGRKVAVIGYGSQGHAHSLSLRDSGVQVKVGLKEGSKSREKVAEQGLEVDTPAEVAKWADVIMLLAPDTAQAEIFKNDIEPNLEDGNALFFGHGLNIHFGLIKAPANVTVGMVAPKGPGHLVRRQFVDGKGVPCLIAIDQDPKGEGQALALSYAAAIGGARAGVIKTTFKEETETDLFGEQAVLCGGTEELVKTGFEVMVEAGYAPEMAYFEVLHELKLIVDLMYEGGIARMNYSVSDTAEFGGYLSGPRVIDAGTKERMRDILKDIQDGTFVKRLVANVEGGNKELEDLRKKNAEHPIEVTGKKLRDLMSWVDRPITETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGP4</accession>
    <name>A0A132PGP4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854166.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21496">
        <property type="protein sequence ID" value="KWX21496"/>
        <property type="gene ID" value="AFM11_25130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2387"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="25249" checksum="6F60243FED21202C" modified="2016-06-08" version="1">MTYPPNNPPASPPPGPDGPWQPPQQPSPYGEQQYGAPEYGAQPPYGAPQYGAPGQPYGQQPQYGAPQQPYGAPQQPYGYGAPQPGYPYPQPQPSGGNRKGLIIGGVVAAVVALVVIVGVVIAMVMPSSDERAIGQLLKDVGSTEDFSAALDQYFCSGDQELFNFSVLEDLGIEPPDINSLPMEKPDESATIGDIKVDGDTATAKVESDSGSGTMHFRKESGDWKICMTDSPNLADIAGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH28</accession>
    <name>A0A132PH28_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_23845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853449.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24300"/>
    <dbReference type="EnsemblBacteria" id="KWX21574">
        <property type="protein sequence ID" value="KWX21574"/>
        <property type="gene ID" value="AFM11_23845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2127"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="16"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="305" mass="31134" checksum="7E5A2E244E169850" modified="2016-06-08" version="1">MRNAPVSDEAPVGLFVGLATLDVIHRITKPPAVNEKVTSTAQFVAAGGPAANAAVTFAALGGQAILVTALGDDPIADLIRADLTAYGVTVVDAAAGSTRAVPVSAVSVVESTGDRSVVSLDAVNSDASPPADIGNLVADADVVLVDGHHPVIARAAVAHAAARATTVVVDAGRWKPVMSDVVPQATDMVCSNDFRVPGTHDSASSAAALVGSGVRTVVCTHGGDPVEWWSGGEFGSVPVEPVVVVDTLGAGDAFHGAYAYFSTFGSSVAERIDRSARVAALRCSVVGPRAWLTELHTDQTRKRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH59</accession>
    <name>A0A132PH59_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853544.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24140"/>
    <dbReference type="EnsemblBacteria" id="KWX21604">
        <property type="protein sequence ID" value="KWX21604"/>
        <property type="gene ID" value="AFM11_24015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2162"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="339" mass="37580" checksum="83057093F5C08AD2" modified="2016-06-08" version="1">MTAAPILIEPKLPDPRGPLSMAVVSLLAERAPSNHLSRVEASLGDSDPYGIDLQLALYVCYELHYRGFAGVDPGWEWNPCLLHLRGKLEHAFLSEVRRGVGEIQPDETAMAEIEQLSIEPVDGDGLSYYLRDKGTWEQMREYFVHRSLYHLKEGDPHAWAIPRLMGQAKASFVAVEFDEFGGGRGPRLHQQLFADLMDAAGLDSTYLGYLDNVPAETLAVVNLMSLFGLHRRLRGAAIGHFASTEITSSPGSRRLVDALERLGAPQPCVGFYAEHVEADAVHEQVVRTDVVGDLVAREPHLDQDVVFGIRAHALVEDRLADHMLECWADGRSSLRRPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH93</accession>
    <name>A0A132PH93_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24305</name>
        <name evidence="4" type="ORF">AWC31_23810</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853909.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21728">
        <property type="protein sequence ID" value="KWX21728"/>
        <property type="gene ID" value="AFM11_24305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15725">
        <property type="protein sequence ID" value="ORX15725"/>
        <property type="gene ID" value="AWC31_23810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2220"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453077" evidence="2">
        <location>
            <begin position="32"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX15725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="164" mass="16744" checksum="B181BAB07D1294BD" modified="2016-06-08" version="1">MLDSKFSLRLSAVAAATGLALLVAGIPTAVAAPASDGQGYIDSTARCESADATVLFGSTEQSRVAICTVSGGDYEYRGVRVRDGARLVIPATRSDDGSFLAENAGIEYLVTAKSLVLSAGERVIREEPMVDFHGPGASASEETTTPSTPLPPPLPAEVGGSGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHB6</accession>
    <name>A0A132PHB6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853517.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21597">
        <property type="protein sequence ID" value="KWX21597"/>
        <property type="gene ID" value="AFM11_23970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2152"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453282" evidence="2">
        <location>
            <begin position="31"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="14752" checksum="870C6030F3AF65B1" modified="2016-06-08" version="1">MTINFAQIAVRVVAGAGLCAAAAVLSPHAAATPLKTGGYKCVNMAAGAAGAAPAAPCSAAAVEASGVVAPLAPPVPVVPPAGLPPVPVVPPVPLAPPPVPVVPPVPVAPPVPVAGPVAAAPIAAPVAEMGGVATGKGVPTGRPAGAGGPTPGVPIEPGPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHC9</accession>
    <name>A0A132PHC9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bile acid 7-alpha dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853036.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27915"/>
    <dbReference type="EnsemblBacteria" id="KWX21758">
        <property type="protein sequence ID" value="KWX21758"/>
        <property type="gene ID" value="AFM11_23150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1982"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="155" mass="17579" checksum="4FCEF32A91AB7FAB" modified="2016-06-08" version="1">MSGMGDIDDIKQVKYRYLRALDTKHWDEFADTLTEDVAGDYGQSLGEALHFTDRTALVDFMKRSLGPEIITEHRVAHPEITVDGDEATGTWYLQDRVIAPDFNFMLIGAAFYHDSYRRTSDGWKISATGYDRTYDATMSLENLNFKLKPGAALNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHR6</accession>
    <name>A0A132PHR6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_22205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852644.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09005"/>
    <dbReference type="EnsemblBacteria" id="KWX21890">
        <property type="protein sequence ID" value="KWX21890"/>
        <property type="gene ID" value="AFM11_22205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1791"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="203" mass="20921" checksum="760B78840960DF19" modified="2016-06-08" version="1">MSAEVLAGDPLLAARRLLGAQLSGRGVTATIVEVEAYGGPPDGPWPDAASHSYRGPGGRNAVMFGAPGRLYTYRSHGIHVCANVVCGYDGVAGAVLLRAAAVDTGVDVAQGRRGPLVPMAGLARGPGNLCSALGITMDDNGIDLFDADSPVRLALGSGCEVVDGPRVGVSKAADRRWRFWLADRVEVSAYRRSPRAPAPGGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHT4</accession>
    <name>A0A132PHT4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_22235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852657.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08975"/>
    <dbReference type="EnsemblBacteria" id="KWX21896">
        <property type="protein sequence ID" value="KWX21896"/>
        <property type="gene ID" value="AFM11_22235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1797"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="68"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="453"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="637"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1000" mass="107087" checksum="02335D60FD6FC2A6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHZ7</accession>
    <name>A0A132PHZ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22520</name>
        <name evidence="4" type="ORF">AWC31_08690</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852751.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08690"/>
    <dbReference type="EnsemblBacteria" id="KWX21941">
        <property type="protein sequence ID" value="KWX21941"/>
        <property type="gene ID" value="AFM11_22520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10230">
        <property type="protein sequence ID" value="ORX10230"/>
        <property type="gene ID" value="AWC31_08690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1854"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX10230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="147" mass="15249" checksum="1651FDE20E0EADA3" modified="2016-06-08" version="1">MSAYRTVVVGTDGSDSSLRAVDRAGQIAAGSNAKLIIATAYFPQSEDQRAADVLKDEGYKMAGNAPIYAILREATDRAKAAGATDIEERPIVGAPVDALVELADDVKADLLVVGNVGLSTIAGRLLGSVPANVARRSKTDVLIVHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHZ8</accession>
    <name>A0A132PHZ8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbpA</name>
        <name evidence="2" type="ORF">AFM11_22745</name>
        <name evidence="3" type="ORF">AWC31_08455</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003880369.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08455"/>
    <dbReference type="EnsemblBacteria" id="KWX21979">
        <property type="protein sequence ID" value="KWX21979"/>
        <property type="gene ID" value="AFM11_22745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10190">
        <property type="protein sequence ID" value="ORX10190"/>
        <property type="gene ID" value="AWC31_08455"/>
    </dbReference>
    <dbReference type="GeneID" id="29424816"/>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1901"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="112" mass="12943" checksum="B21E9A4B74F85BEE" modified="2016-06-08" version="1">MADRVLRGSRLGAVSYETDRNHDLAPRQVARYRTENGEEFDVPFADDAEIPGTWLCRNGLEGTLIEGDVPEPKKVKPPRTHWDMLLERRSVEELEELLKERLDLIKTKRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI34</accession>
    <name>A0A132PI34_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853731.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23725"/>
    <dbReference type="EnsemblBacteria" id="KWX21662">
        <property type="protein sequence ID" value="KWX21662"/>
        <property type="gene ID" value="AFM11_24400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2240"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="70"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="376" mass="40752" checksum="C597B007B11DF44F" modified="2016-06-08" version="1">MDRKRVLIAGFGDTGVLTAIRLARRFDVVGISVNPGLVSGQEVGVRLARPDDWARDYWIGFDRFRALDGVGTVHGTLTGSDLAARTVSVEDAHGNPRSEHYDALVIATGVTNGFWRQRVLQTAADVEEGLRAAHDRLGASRSVAVIGGGAAAVSSAANLAIRWPGTRVGLYYPGESLLPQHHRRVRQRIESRLCAAGVTLHPGHRAVVPDGFDCDAITADPVYWSTGQPPLRSDAVLWAIGRVRPNTGWLPRNVLDDRGFVRVTPELQVPGAPGVFAIGDVAATDPLRSSARNRADGLVAGNVAAYFTGGRMRAYRPPATRWGSVLGVQPNGLEVFAPNGFAFRFPAWSIDRILQPWIVRRGIYRGVRDQYMVTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI88</accession>
    <name>A0A132PI88_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852292.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04145"/>
    <dbReference type="EnsemblBacteria" id="KWX22060">
        <property type="protein sequence ID" value="KWX22060"/>
        <property type="gene ID" value="AFM11_21330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1613"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="188" mass="18646" checksum="3F15FCD580F9ED0B" modified="2016-06-08" version="1">MISKGLSYGVLSARRRIREMVLPVLTTATGAFLVVLVFGMMSGIRSQSAALGHADDINRAVILIAVTVLLVGVVEVAVATTRTVAHRTRELGVLGANGIPRGPVVAALLVEPVVAAILGALLGAALAAGTGIVAALAGFAPTGVSYVGLGLGALLAVGVSIVAAVATSIVPTWNAASRPPIRSLTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIA2</accession>
    <name>A0A132PIA2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_22355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852700.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08855"/>
    <dbReference type="EnsemblBacteria" id="KWX21917">
        <property type="protein sequence ID" value="KWX21917"/>
        <property type="gene ID" value="AFM11_22355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1821"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="264" mass="28954" checksum="F3CD9A535C6861DF" modified="2016-06-08" version="1">MSDKTIRVERDTETPSIATVVLSNPDSHNAISLGMYQRIPEVFAELDADPAVKVVVVRGEGTRSFASGADISEFEQVRGNSESAKAYNEQVAAAEHAVEGCSKPTIAMVHGYCIGGGCGLALACDLRFADERSRFGITPAKLGLVYSLESTKRLVDVVGPSRAKWILFSGQHIYADDSLRLGLIDELVPAEDLEKHTYEFARLVTTRAQFSVRSSKRIVELVLGGQSTDDDVTVEIRNSSFDTDDYAEGVRSFLEKRPPRFTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIA8</accession>
    <name>A0A132PIA8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852371.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04380"/>
    <dbReference type="EnsemblBacteria" id="KWX22098">
        <property type="protein sequence ID" value="KWX22098"/>
        <property type="gene ID" value="AFM11_21575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1663"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="29"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="272" mass="27265" checksum="EA60C2E27C70B87A" modified="2016-06-08" version="1">MTTYQTPQPITAVVEVVAGAVRLVASDRDDTVVEVRPRDPNRASDVRVAEQARVEFHNGTLKVSAGRKVLSLGRGGAVHIDIELPAKSRLKASSASADVEADGAYSECRFASASGHVRIGTVIGNVKADSASGDVTVDDVVGNASISTASGEAAIGRIEGDVKFQAASGGITVGLLRGNMKAQTASGSVAVTAAVNGGLNAQTASGEVEVGIPEGTAARLELASKSGSVTNALQTADGPADGDDTVVVHARTGSGDISIRRAAGPVPAGEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIM1</accession>
    <name>A0A132PIM1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_23700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853328.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28420"/>
    <dbReference type="EnsemblBacteria" id="KWX21852">
        <property type="protein sequence ID" value="KWX21852"/>
        <property type="gene ID" value="AFM11_23700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2096"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="253"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX21852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="36584" checksum="94EC4C616714CBF4" modified="2016-06-08" version="1">MPIATPEVYAEMLGRAKEHSFAFPAINCVGSESINAAIKGFADAGSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFAHVIAEKYPITVALHTDHCPKDKLDTYVRPLLAISAERVAAGRNPLFQSHMWDGSAVPIDENLSIAQELLKQAAAAKIILEVEIGVVGGEEDGVEAEINEKLYTSSEDFEKTIDALGAGEHGKYLLAATFGNVHGVYKPGNVVLKPEVLAEGQRVAAAKLGLGDSAKPFDFVFHGGSGSLKSEIEDSLKYGVVKMNVDTDTQYAFTRPVAAHMFTNYDGVLKVDGEVGNKKTYDPRSYLKKAEASMSERVVEACNDLHSAGRSVTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIR4</accession>
    <name>A0A132PIR4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydrogenobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hydrogenobyrinic acid a,c-diamide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="6" type="ORF">AFM11_21915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:12544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:77873"/>
            <dbReference type="ChEBI" id="CHEBI:77874"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.9" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852480.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04720"/>
    <dbReference type="EnsemblBacteria" id="KWX22154">
        <property type="protein sequence ID" value="KWX22154"/>
        <property type="gene ID" value="AFM11_21915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1731"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043802">
        <property type="term" value="F:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="9"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="256"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="457" mass="46966" checksum="6385FD4E6260C500" modified="2016-06-08" version="1">MSAVPTPAVVIAAPASGSGKTTVATGLIGALRRAGHTVAPFKVGPDFIDPGYHAMAAGRPGRNLDPVLVGEELIGPLYRHGSAGADLAVVEGVMGLFDGRIEDQMTGTPRGSAAQVAGLIGAPVVLVVDARGQSQSIAALLHGFLTFDSAVRIAGVILNRVGSSRHEAVLRQACEHAGVAVFGAIPRSDELTVPSRHLGLVTAIEHGRQARAAVAAMTELMARHVDLAAVVSAADARVAAQPWEPGGAEPVTDVTVALAAGKAFSFGYTEHGELLRAAGARVAEFDPLVDPLPAGTDALVLPGGFPEQFSAELSANTAVRQQIRDLAARGAPVHAECAGLTYLVDDLDGAPMCGVLAGSARFTERLTLGYRDAVAVVDSSLHAAGDRVTGHEFHRTAVTFADDHPPAWAFAKPGQAAHRDGAVHRGVHAGYLHTHPAAHPQAITRFVASAARSKLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIT5</accession>
    <name>A0A132PIT5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21545</name>
        <name evidence="3" type="ORF">AWC31_04360</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852596.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04360"/>
    <dbReference type="EnsemblBacteria" id="KWX22213">
        <property type="protein sequence ID" value="KWX22213"/>
        <property type="gene ID" value="AFM11_21545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10680">
        <property type="protein sequence ID" value="ORX10680"/>
        <property type="gene ID" value="AWC31_04360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1657"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024341">
        <property type="entry name" value="DUF2631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10939">
        <property type="entry name" value="DUF2631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="84" mass="9572" checksum="2426620280630BFB" modified="2016-06-08" version="1">MASTEVDRTNGVDVEDVPSAEWGWSKENIKVIHIGGLLSAAFLLIMMHGNHVGHVEDWFLIGFAAIIVFAVARDWWLRRRGWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJF3</accession>
    <name>A0A132PJF3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851921.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11505"/>
    <dbReference type="EnsemblBacteria" id="KWX22478">
        <property type="protein sequence ID" value="KWX22478"/>
        <property type="gene ID" value="AFM11_20210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1377"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="138" mass="15097" checksum="37026EF122DE2FA0" modified="2016-06-08" version="1">MSGNGPFGFDPEDFDRVAREAGEGLRDALEGMTRFFTTSGERAGWAGLLDEFSRMSRPRTDPETTGEKGDGVWAIYTVDDNGGAHIEQVFPTELDALRANATNTDPVRRVRFLPYGIAVSVLDTDTTRADTDTTDSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJV7</accession>
    <name>A0A132PJV7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_20940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852132.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06360"/>
    <dbReference type="EnsemblBacteria" id="KWX22302">
        <property type="protein sequence ID" value="KWX22302"/>
        <property type="gene ID" value="AFM11_20940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1529"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="318" mass="33987" checksum="DFB53E47068EB6A6" modified="2016-06-08" version="1">MTAPIGPVDASKIPRFAGPTTFARLPRLDQVTKADVVVAGVPFDSGVSYRPGARFGPTHVRESSRLLRPYHPGLDVSPFDLVQVADAGDIAVNPFNIHEAIETIEGAARELTSDGTKLVTIGGDHTIALPLLRAAAANHGPVALVHFDAHLDTWDTYFGAEYTHGTPFRRAVEEGIVDTEALSHVGTRGPLYGKKDLEDDRRFGFGIVTSSDVYYQGVREVVDKLRQRVGNRPVYVSIDIDVLDPAHAPGTGTPEAGGMTSRELLEILRGFRGLNIVGADVVEVAPAYDHAEMTGVAASHVAYDLVSLFALGQESSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJW3</accession>
    <name>A0A132PJW3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19260</name>
        <name evidence="4" type="ORF">AWC31_15340</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851673.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15340"/>
    <dbReference type="EnsemblBacteria" id="KWX22639">
        <property type="protein sequence ID" value="KWX22639"/>
        <property type="gene ID" value="AFM11_19260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17802">
        <property type="protein sequence ID" value="ORX17802"/>
        <property type="gene ID" value="AWC31_15340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1186"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453412" evidence="1">
        <location>
            <begin position="33"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX17802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="340" mass="34260" checksum="933CFACC64284693" modified="2016-06-08" version="1">MGKLRSRPVTSVLLAAFATAAALVIPSAPAAAAPADPVAAAAQVEPAVARIDTVVDYQQAYGIGTGIVLSPGGEVLTNYHVVQGANSINATVAGQSFAADLVGYDRRNDIAVLQLRGAGGLPVAPIGDSRALAEGEPVVALGNAHGTGAPLTREVGTVTAFGRTVNAEDELTGSTDELNGLFEFAAPVRAGDSGGPVVNSAGQVVGMTTAASVNFRMGPGGKGFAIPINDAMAVAGQIRSRTPSDLVHIGPPTLLGVGVRTAPRQNAGVIIQDVLRGGPAEAAGLMPGDTLTVIDGTPLDSARTLTLVLDRRYPGDVIDLTWLDRSGQERTGKATLAAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK58</accession>
    <name>A0A132PK58_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15320"/>
    <dbReference type="EnsemblBacteria" id="KWX22729">
        <property type="protein sequence ID" value="KWX22729"/>
        <property type="gene ID" value="AFM11_19240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1182"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="256"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="507" mass="53635" checksum="4CEEAF83134C8A27" modified="2016-06-08" version="1">MTNVAQPIAELDGIAKSYNANTVLRDVSLKLLPGRVHVLAGENGAGKSTLIKILSGAQRNDSGRVLIDGQPVELAGPRDARARGVAVVHQELSLVPELTVADNIVLGREPRRRGARLDRRRATGDATAALALIGANIDSGARVATLTSGEQQLVEIARALAEQPRLLILDEPTAALSQREADRLLQIVAELRDSGLAILYISHRMEEIARIADEVTVLRDGTVTDHMLADEMTEDRIVTSMVGRPVQNLFSQATAADPDNVRLQVRGLCSASIGAADFDVHRGEVLGLAGIVGAGRSELCRLIAGVDRAAGGSVTVDGEIVELRGIAGAASAGIAMLPESRKTQGLFLDMSIADNVCLGTACGRERFGRTTRASRRRGAKPLTDAMRVKSTDLDQPVGQLSGGNQQKVLLARCLAKQPKVLILDEPTRGVDVGAKADIYALIEQVARAGVAIVLVSSELPELLGLADRVLVMRQGRVVAELSGAEANEHNVIRHATGSVAKPLEVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK86</accession>
    <name>A0A132PK86_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="6">FDTS</shortName>
            <ecNumber evidence="6">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thymidylate synthase ThyX</fullName>
            <shortName evidence="6">TS</shortName>
            <shortName evidence="6">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">thyX</name>
        <name evidence="7" type="ORF">AFM11_17530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851070.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05050"/>
    <dbReference type="EnsemblBacteria" id="KWX22756">
        <property type="protein sequence ID" value="KWX22756"/>
        <property type="gene ID" value="AFM11_17530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.861"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="27716" checksum="EF5483BA71D6CDF8" modified="2016-06-08" version="1">MAEIAPLRVQLIARTEFQAPPDVPWETDADGGSALVEFAGRACYQSWSKPNPKTATNDGYIRHIIDVGHFSVLEHASVSFYITGISRSATHELIRHRHFSYSQLSQRYVPEHDAEVVVPPGFEDDPELVELFSAAADASRAAYTELLSRLEARFADQPNAVLRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIACLRELVAVAPAVFSDFDIYTLADGTEVATSPLATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKC2</accession>
    <name>A0A132PKC2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851136.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11855"/>
    <dbReference type="EnsemblBacteria" id="KWX22789">
        <property type="protein sequence ID" value="KWX22789"/>
        <property type="gene ID" value="AFM11_17735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.902"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="228" mass="24776" checksum="176AD73EF5785102" modified="2016-06-08" version="1">MAIDVTVLRVFTDSDGKFGNPLGVVDNSTVAPTDRQRIATELGYSETIFIDLPQPGGTTAHAHIYTPAAEIPFAGHPTVGASWWLRDIGTPIHTLQVPAGIVQVSYDGDLAAISARSEWAPEFAIHDLPSTEELFAAEPDDYADDVEHYLWTWVDQEEGVLRSRVFAANLGIPEDEATGAAAVRMTDYLSRDLTIVQGKGSVISTRWSPEGWVRVAGRVVNDGTTRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKE9</accession>
    <name>A0A132PKE9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12000"/>
    <dbReference type="EnsemblBacteria" id="KWX22820">
        <property type="protein sequence ID" value="KWX22820"/>
        <property type="gene ID" value="AFM11_17930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.941"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="SSF57184"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="344"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="377"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="482" mass="49671" checksum="F0DF6085686FCE16" modified="2016-06-08" version="1">MFVVAACGPSGDAPEPGGTDSDETAPAEAQDAIVNGLETMFTWYPVRDGSTLDAYNRALPYFGAELRAGKDTLERGNSVWWQEWKAKKAEVTADALLVAGEHPADKPDTVQRAVVVTQTVKTPDGKELESNTMRIERVVAKKSPEGWRVEEISFFPVNEFRTQVCPPGQSHQPPPDGPCAPNPPPPPKQCPDGTTVAPDQMCPEPRIAPRTKQCPDGSTVAADATCPTGPKVTSPQPEPCPEGQVRDANGTCQPEPCPEGQVRGSDGTCQPEPCPDGQVRGSDGTCQPEPCPDGQVRGSDGTCGCPAGTELYNGTCVSPCPEGQVRGSDGTCGCPAGTELYNGSCVSPCPSGQVRGAGGTCGCPAGTELYNGSCVSPCPSGQVRGAGGTCGCPAGTELYNGSCVSPCPGISSRNASGTCVCPPGYTGTPETGCGSYVGAGPPPPGPRVEQMSFEVSMPCPYVVATQRKTFVGRVMAQPGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKL9</accession>
    <name>A0A132PKL9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851364.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12570"/>
    <dbReference type="EnsemblBacteria" id="KWX22891">
        <property type="protein sequence ID" value="KWX22891"/>
        <property type="gene ID" value="AFM11_18545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1043"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="363" mass="39871" checksum="89CD5D8E6440FD5E" modified="2016-06-08" version="1">MTTTDRLGHEFLWYIPNTVEPGHRGDDTVDGWGSLDYSVDLALRAEQHGWAGALIGTGWGRPDTFTVATAIAARTSTFTPLVAIRPGYWHPAHFASAAATLDQLSRGRLFINIVSGTDDLAAYGDGEFDKSRRYDRTREFLQVVRRLWREEDVSFDGEFFRVEHSTVAPRVFGAEQGRHPRLYFGGASTAAEHVAVAEADVQLFWGEPLDGIAERIDRLKTLSDKLGREHAPLEFGLRVTTLIRDTTEQAWRDAEAKIASIAGRPDLHGRRQGAAVGQQRLLDLAERGEVLDTCLYTTPGRYGGGGAGTTWLVGSAVDVGAALQRYAELGVTHFVLSDTPYKSEVGRVGDELLPLLQTTSALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKN2</accession>
    <name>A0A132PKN2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_17815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22804">
        <property type="protein sequence ID" value="KWX22804"/>
        <property type="gene ID" value="AFM11_17815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.918"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="76"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="283" mass="29344" checksum="71F9470F7026A21B" modified="2016-06-08" version="1">MQTGSGADGGAAADAAVSMVARVALIMNAFDEPGASLRLDQVVARTGLPRSSVHRILKQLHEAGLLQHRSDGYRVAASPLPVTQLDHSQLRGVASRIIERLHADTGLVVQLGVLLGGDVIYLDKLAGRHAAAVPTRVAGHTPAHASALGKAMLAQLPAEEVDAIVGPRLAKRTPATIADLATLHRELARIRSRHGLAYDNGELATGLASVAAPIRGADGELAGLSLTGAVPMHRLQRTAPFVMRAAGVISAQLGRPAAQSADASATDTMLSRVLRTLSSDAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKP8</accession>
    <name>A0A132PKP8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17965</name>
        <name evidence="4" type="ORF">AWC31_12035</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851214.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12035"/>
    <dbReference type="EnsemblBacteria" id="KWX22824">
        <property type="protein sequence ID" value="KWX22824"/>
        <property type="gene ID" value="AFM11_17965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18720">
        <property type="protein sequence ID" value="ORX18720"/>
        <property type="gene ID" value="AWC31_12035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.948"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="208" mass="22523" checksum="946630BEE0FC1041" modified="2016-06-08" version="1">MQRRVSTYVYADDPILQAGVISQLRMRPEVDVVEAGDLAGVDVGIAVADALDDETIRILRSLKKAGVAHTVLVMSTIDDSTVVSAAEVGVSGLLRRGEATPDLLVRTVQKVASGEGVIPPDLLGNLLGQVGRLQRQVLSPRGLTFTGLSDREIQVLRLIADGHDTNEIARQLCYSQRTVKNVLHDVTTRLQLRNRSHAVAYAVREGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKT9</accession>
    <name>A0A132PKT9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="9 10">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">miaB</name>
        <name evidence="15" type="ORF">AFM11_17660</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="9 10"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851416.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05180"/>
    <dbReference type="EnsemblBacteria" id="KWX22913">
        <property type="protein sequence ID" value="KWX22913"/>
        <property type="gene ID" value="AFM11_17660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.887"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="13">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="156"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="405"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX22913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="516" mass="56125" checksum="228AB80F5365131C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLI8</accession>
    <name>A0A132PLI8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_15405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850220.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23211">
        <property type="protein sequence ID" value="KWX23211"/>
        <property type="gene ID" value="AFM11_15405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7196"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="329" mass="35912" checksum="0162A19E7DF5A386" modified="2016-06-08" version="1">MADVSRAAGFSMQTVSRALSRPETVTEETLERVTRAVAETGYVPNLAASHLASNRSRTVAAILPAISTSVFSDTLRSATTRLAPHGYQLIVGYTDYHPEREEELVRSFIQRRPDGFFIVGTRHTPGTTRLLKGYGHPVVETWDWNDSPTDTLVGFSNRKALADMVRHLVTQGHRRLAFAGVITGGDERAQRRLEGFQDAVADLLPDEPVRVVDLPGEPIAMDTGVRLLEVALERHPEITALVFPTDVFASAAVLAAPDLGVDVPGRLAITGFGDFEMARHLRPALTTVAVDSQQIGSRAADLLLARMLDQPIDEPSVDIGYRIEVRQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLM5</accession>
    <name>A0A132PLM5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">topA</name>
        <name evidence="11" type="ORF">AFM11_15625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850300.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16140"/>
    <dbReference type="EnsemblBacteria" id="KWX23248">
        <property type="protein sequence ID" value="KWX23248"/>
        <property type="gene ID" value="AFM11_15625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7247"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="191"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="724"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="842"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="891"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="912"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX23248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="938" mass="102873" checksum="15EFF51F5D9A1D30" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLN3</accession>
    <name>A0A132PLN3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Side tail fiber protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850899.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01765"/>
    <dbReference type="EnsemblBacteria" id="KWX23097">
        <property type="protein sequence ID" value="KWX23097"/>
        <property type="gene ID" value="AFM11_17200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.793"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="236" mass="25975" checksum="A7DAED83987062F7" modified="2016-06-08" version="1">MAEQKASRGIEGALVKLWRGGDYQLTVTGRTELTPHYLRLHFNAERLLAEQRLHPTMWVRGWFPDGARAHQRGYTLANPDREAGTVDIDFAMHDGVATRWARAARPGDVLEVTVLGSNFALPEPQPAGYVIVGDTASLPAINSLLDAIGDAPARVFLEAGHDDDRELPVAGGADITWVDRDDEALVEAVSSSAFDAADHFGWVACNNRTTRAVARVFREQYNIPRKSIKAQAYWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLN5</accession>
    <name>A0A132PLN5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15730</name>
        <name evidence="4" type="ORF">AWC31_16035</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850333.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16035"/>
    <dbReference type="EnsemblBacteria" id="KWX23265">
        <property type="protein sequence ID" value="KWX23265"/>
        <property type="gene ID" value="AFM11_15730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17922">
        <property type="protein sequence ID" value="ORX17922"/>
        <property type="gene ID" value="AWC31_16035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7269"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX17922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="168" mass="18430" checksum="E96C73B2F7C85F17" modified="2016-06-08" version="1">MSIGDRKNGVPATVTSIPLVDPHAPKPDPSIGDLVKDATAQVSTLVRAEVELAKAEITRDVKKGLTGSVFFIAALVVLFYSTFFFFFFLAELLDTWLWRWVAFLIVFGIMVLVTAALAVFGYLKVRRIRGPRQTIESVKETREALTPGHDKNPAIGAGQRPATDPSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLS5</accession>
    <name>A0A132PLS5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850382.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16460"/>
    <dbReference type="EnsemblBacteria" id="KWX23289">
        <property type="protein sequence ID" value="KWX23289"/>
        <property type="gene ID" value="AFM11_15885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7302"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="126" mass="13949" checksum="AA88D3FA6880B848" modified="2016-06-08" version="1">MADRIELRGLKVRGNHGVFDHERRDGQDFVVDITVWLDLRRAAATDDLAETLDYGALAQRAADIVAGPPRNLIETVSAEIADDLMVDERLHAVEVVVHKPSAPIPLTFDDVAVVARRSRRGERGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM49</accession>
    <name>A0A132PM49_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_15740</name>
        <name evidence="7" type="ORF">AWC31_16025</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850338.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16025"/>
    <dbReference type="EnsemblBacteria" id="KWX23267">
        <property type="protein sequence ID" value="KWX23267"/>
        <property type="gene ID" value="AFM11_15740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17920">
        <property type="protein sequence ID" value="ORX17920"/>
        <property type="gene ID" value="AWC31_16025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7271"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX17920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="396" mass="41044" checksum="4783CD2380AE7F55" modified="2016-06-08" version="1">MTPSLWLDFAVLAIGFVAAISGWRSGALGSLMSFIGVVLGAVAGVLLAPHVIPHISGDRTKLFATLFLILALVVVGEIAGVVLGRAVRGTIRNRVLRVFDSAVGVSLMLVAVLVAAWLLGSLLTSSDQPNLAAAVKGSRVLTEVDKVAPSWLRSVPNRLSGLLDTSGLPDVLEPFGRTPIVNVDAPDAALATDAVVAATRPSVVKIRGIAPSCQKVLEGSGFVVAPNRVMSNAHVVAGADSVTVEVDGQTYDAGVVSYDPNADISILDVPNLPSTPLPFAEDPAPQGTDAVVMGFPGGGDFLATPARVREIIELNGPDIYRTTTVTREVYTVRGTVRQGNSGGPMINRSGKVLGVVFGAAVDDVDTGFVLTAKEVERQLAKIGNTQRVATGTCINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM51</accession>
    <name>A0A132PM51_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_14035</name>
        <name evidence="6" type="ORF">AWC31_09435</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849686.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09435"/>
    <dbReference type="EnsemblBacteria" id="KWX23409">
        <property type="protein sequence ID" value="KWX23409"/>
        <property type="gene ID" value="AFM11_14035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09165">
        <property type="protein sequence ID" value="ORX09165"/>
        <property type="gene ID" value="AWC31_09435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6911"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="262" mass="28198" checksum="0E4C28C139300769" modified="2016-06-08" version="1">MPSPSSDAGGALQIRNVAHRYGRGASEVTALGPVNLEVEPGAFLVLVGASGCGKSTLLRLIAGFETPSEGEVQVAGTQPTPGVTSGVVFQQPRLFPWRTVGGNVELALKYAKVPRERRAERRDQLLERVGLEGTARRKIWEISGGQQQRVAIARALAAETPLFLLDEPFAALDALTRERLQEDVRQVSAESGRTTVFVTHSADEAAFLGSRIVVLTRRPGKVALDLPVDLPRTGVDPHELRRSPEYLRLRAEVGEAVKAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMG3</accession>
    <name>A0A132PMG3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_14760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849938.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18140"/>
    <dbReference type="EnsemblBacteria" id="KWX23526">
        <property type="protein sequence ID" value="KWX23526"/>
        <property type="gene ID" value="AFM11_14760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7061"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="11">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="12">
        <location>
            <begin position="137"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="13">
        <location>
            <begin position="260"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX23526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="397" mass="41236" checksum="C9ADCB12927B86E6" modified="2016-06-08" version="1">MATTTAGLTDLKFRVVREDFADAVAWVARNLPTRPTIPVLAGVLLTGTEDGLTISGFDYEVSAEVQVAAEIASAGSVLVSGRLLSDITKALPAKPVEVSVEGTRVALTCGSARFSLPTLAVEDYPALPALPDETGVVSADLFAEAIGQVAVAAGRDDTLPMLTGIRVEISGESVVLAATDRFRLAVRELTWATTAGDVEAAVLVPAKTLAEAAKAGTDGTQVHLALGSGAAVGKDGLLGIRSDGKRSTTRLLDAEFPKFRQLLPTEHTAIATIGVAELTEAIKRVALVADRGAQIRMEFSDDVLRLSAGADDVGRAEEDLPVSFAGEPLTIAFNPTYLTDGLGSLHSERVTFGFTTPSRPAVLRPAGEDDGTGGGSGPFPAAQTDYVYLLMPVRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMP8</accession>
    <name>A0A132PMP8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17950"/>
    <dbReference type="EnsemblBacteria" id="KWX23611">
        <property type="protein sequence ID" value="KWX23611"/>
        <property type="gene ID" value="AFM11_14950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7101"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="31054" checksum="1D6855613A5A3B32" modified="2016-06-08" version="1">MRVATRQTSATRAKDSDRNDTCKVLDSALSEGQLSMEEHRQRVSAATNATTLGELAALVADLQNSNAPVQLPTLKQPRQPGSGGWGFKLATAVVLVLLGMGIGWGLYGNTSSPLSFQTDPGAKPDGIAAEVLTPPRQLQSLNGVNGLFQQMRNKFGNTMGYELHIDPDSAMLYRPDPQDSRKEVYYRYVGGWGDPQSPDAVDEEDRLVDLAKFDIEKALAILRGAPETLNTKPEDVSSSWLRITPSEDPSTPELVNVEVIVSSDFGGGTIDLYPDGTVKEIYRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMR1</accession>
    <name>A0A132PMR1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849845.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18320"/>
    <dbReference type="EnsemblBacteria" id="KWX23487">
        <property type="protein sequence ID" value="KWX23487"/>
        <property type="gene ID" value="AFM11_14505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7009"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="135" mass="14840" checksum="24113C27ECDA9819" modified="2016-06-08" version="1">MQQTSWGPPTAGIAGCGIAGLMMAIAAVTLITDPPGRVLAGIAAVGLLTFATFSWRARPKLAISEDGLTVRGWWHTRILRRNDVRSIRITEFRRIARKVRLLEIDTADDRLLVMTRWDLGTDPLDVLDALKAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMZ4</accession>
    <name>A0A132PMZ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_13035</name>
        <name evidence="7" type="ORF">AWC31_03320</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849191.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03320"/>
    <dbReference type="EnsemblBacteria" id="KWX23708">
        <property type="protein sequence ID" value="KWX23708"/>
        <property type="gene ID" value="AFM11_13035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11167">
        <property type="protein sequence ID" value="ORX11167"/>
        <property type="gene ID" value="AWC31_03320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6700"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX11167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="228" mass="24930" checksum="2478C2AB5A2E37DC" modified="2016-06-08" version="1">MTSVLIVEDEESLADPLAFLLRKEGFEATVVGDGPSALAEFERSGADIVLLDLMLPGMSGTDVCKQLRARSSVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARIRAVLRRGADTDETGLSDGVLEAGPVRMDVERHVVSVNGEQITLPLKEFDLLEYLMRNSGRVLTRGQLIDRVWGADYVGDTKTLDVHVKRLRSKIEADPANPVHLVTVRGLGYKLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNC9</accession>
    <name>A0A132PNC9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13905</name>
        <name evidence="3" type="ORF">AWC31_29790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000018">
        <property type="protein sequence ID" value="ORX13641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849547.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29790"/>
    <dbReference type="EnsemblBacteria" id="KWX23849">
        <property type="protein sequence ID" value="KWX23849"/>
        <property type="gene ID" value="AFM11_13905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13641">
        <property type="protein sequence ID" value="ORX13641"/>
        <property type="gene ID" value="AWC31_29790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6877"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="103" mass="11447" checksum="E1236857DA7AB263" modified="2016-06-08" version="1">MGVCLPSPQVIVGSLLLAAAVLVFAFGIALRLFIGRRADSDRMRRRMFAFRRTAVARVFFGQIDDDEVFDPDELDQMVLMPTIVLACGLCLTGFFLLGYKVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP48</accession>
    <name>A0A132PP48_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03930"/>
    <dbReference type="EnsemblBacteria" id="KWX23812">
        <property type="protein sequence ID" value="KWX23812"/>
        <property type="gene ID" value="AFM11_13685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6833"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="169" mass="18395" checksum="0C8E0421AEC7B836" modified="2016-06-08" version="1">MGVKSYTTLIAAVAAERLLELVVSKRNLEWSKANGGKEFGAGHYPVMVALHTGLLVGALAEGRRRTFRPALGWPMFAVVLAAQGLRWWCITTLGRQWNTRVVVVPGASRVVDGPYRVIPHPNYVAVVAEGAALPLVRGGWITALVFSIANAVLLRTRIRVENEALQDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP83</accession>
    <name>A0A132PP83_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12365</name>
        <name evidence="6" type="ORF">AWC31_09615</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848754.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09615"/>
    <dbReference type="EnsemblBacteria" id="KWX24140">
        <property type="protein sequence ID" value="KWX24140"/>
        <property type="gene ID" value="AFM11_12365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09290">
        <property type="protein sequence ID" value="ORX09290"/>
        <property type="gene ID" value="AWC31_09615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6552"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="Gua-sp_ribonuclease_N1/T1/U2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="SSF53933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453458" evidence="4">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="127" mass="13643" checksum="7E161D28BA97ADAD" modified="2016-06-08" version="1">MRRRIGTGLAAVLCAVVVGCESGTDTAAADGTCSLDTLPPQAAETVELIEAGGPFPYPRNDGVVFGNFEGRLPAHERGYYREYTVPTPGLSHRGKRRIVTGGKPLDDPAEYYYTGDHYESFCLIGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPE4</accession>
    <name>A0A132PPE4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_11615</name>
        <name evidence="8" type="ORF">AWC31_30435</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848861.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30435"/>
    <dbReference type="EnsemblBacteria" id="KWX24175">
        <property type="protein sequence ID" value="KWX24175"/>
        <property type="gene ID" value="AFM11_11615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12670">
        <property type="protein sequence ID" value="ORX12670"/>
        <property type="gene ID" value="AWC31_30435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6400"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="164"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX12670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="271" mass="29529" checksum="4A396C4E45DF3F32" modified="2016-06-08" version="1">MLRAVAGALPFVPRSETLPDRTVTVDDLTIDPANVAAYAQVTGLRFGDTLPLTYPFALTFPTVMSLVTGFDFPFAAMGSVHIENHITQYRPIAVTDTVSVAVHAENLREHRRGLLVDIVTEIKVGNDTAWHQVTTFLHQQRTSLSDEPKPEPQKQPKLPPPNAVLHITPGQIRHYASVGGDHNPIHTNAVAAKLFGFPTVIAHGMFSAAAVLANIEGQMPDAVKYSVRFAKPVVLPARAGLYVERDGEGWDLTLRHLSKGYPHLSATVRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPJ3</accession>
    <name>A0A132PPJ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_09745</name>
        <name evidence="8" type="ORF">AWC31_05480</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847266.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05480"/>
    <dbReference type="EnsemblBacteria" id="KWX24266">
        <property type="protein sequence ID" value="KWX24266"/>
        <property type="gene ID" value="AFM11_09745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09681">
        <property type="protein sequence ID" value="ORX09681"/>
        <property type="gene ID" value="AWC31_05480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5987"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX09681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="352" mass="37653" checksum="62CA028A2218F4DD" modified="2016-06-08" version="1">MSTQADLDLESHKVVHDERVKEQNKLQRLIIRPEMGAAVGAVGIFVFFLIVAPPFRSPESLATVLYASSTIGIMAVGVGLLMIGGEFDLSAGVAVTTSSLAASMLAYNLHLNLWVGAALALIVSLAVGFFNGYLVMKTKIPSFLITLSTFFMLAGINLAVTKLLSGQVATPSVSDMQGFDSGRTVFASSISVGPVEVRITVLWWILFTLIATYVLFKTRVGNWIFAVGGNQDSARAVGVPVTKVKIGLFMVVGFCAWFVGMHLLFSFNTIQSGQGVGNEFFYIIAAVIGGCLLTGGYGTAIGTLIGALIFGMTNQGIVYAGWNPDWFKFFLGAMLLFAVIANNVVRNYAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ13</accession>
    <name>A0A132PQ13_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_10535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847670.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24393">
        <property type="protein sequence ID" value="KWX24393"/>
        <property type="gene ID" value="AFM11_10535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6147"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01782">
        <property type="entry name" value="MCEVIRFACTOR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="43"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="118"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="361" mass="38553" checksum="0729EBE311F9CCEE" modified="2016-06-08" version="1">MLKYRESKLIKAGFIGTVLMILVIAVGLQPERLAQWATSVRHQALFTEAGGIAVGNDVTLSGIKVGSVTGISLDNGDALITFTIEGKQELGSLTTAHIRTGSLLGERVLTLEPAGSGTLRSTDVIPTSRTSSPYSLTDAVSELTTNTAGTDTASLNQSLDTLSAIIDQLAPRLGPTFDGLSRLSKSINGRNESLASLLKSAADITGVLSARSQQLNTLILNANDLLGVLNDRRQAIVDLLANTAAVSQQLTGLVADNEQELAPTLERLNRVTEILEKNRDNINKMLPDMKKFWLAQAETLANGPYYNAFVPNLLISQAMLQPFMDYAFGFRRGNNAGQPPDNVGPRAELPLPYNGIPGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQH3</accession>
    <name>A0A132PQH3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_07775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846115.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24400"/>
    <dbReference type="EnsemblBacteria" id="KWX24573">
        <property type="protein sequence ID" value="KWX24573"/>
        <property type="gene ID" value="AFM11_07775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5406"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="231"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="299" mass="32423" checksum="E76A6AF35B678514" modified="2016-06-08" version="1">MLYVTLVRRHPRKRVLPVPVRPTLLRPRDADAVRAELRQMAGETGLPLTFGGEVHGDTLLLSEFFGTRTSAMRGLAVRPSAGLGGATMVARRPISVADYRHASAITHDYDGPVLSEGIRSILAVPVVVDGEARAVLYGAYRQSAPIGDRTAAAMVASARRLSHELSVRDEVDRRMRMREAHLAHFGDNVASAEQIREVHADLRRIAAHASKPLATQLGELADRLARALSGDVPTATPLTAREVDVLSQIALGCTNAEAAQRLSLKPETVKSYLRSASSKLGAHSRHEAVSKARRLRQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQJ4</accession>
    <name>A0A132PQJ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_07610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbbQ/NirQ/NorQ/GpvN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846034.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22110"/>
    <dbReference type="EnsemblBacteria" id="KWX24544">
        <property type="protein sequence ID" value="KWX24544"/>
        <property type="gene ID" value="AFM11_07610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5371"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013615">
        <property type="entry name" value="CbbQ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08406">
        <property type="entry name" value="CbbQ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="2">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="CbbQ_C" evidence="3">
        <location>
            <begin position="171"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="264" mass="28845" checksum="BFA98C95A5F4109A" modified="2016-06-08" version="1">MTDNYYANGNEVQLFEQAYRQRLPVMLTGPTGCGKTRLVEHMGLLLSRPVTTISCHDDLTSSDLVGRFMVTGGDVVWTDGPLTRAVKEGEICYLDEVVEARHDSLAVLHSLTDHRRTLYLDRAGEVVYAPETFMLVCSYNPAYRSSLKELKPSFRQRFVTLPMRYLPPEREAEVIVAEAGIELPTAQRLVRCATAIRTADEAFHFEPPSTRVLVTAAHLIAAGATELEAADACVLAPLSSDGAITEGLREVAAASLADADSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQJ8</accession>
    <name>A0A132PQJ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07980</name>
        <name evidence="3" type="ORF">AWC31_24580</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000014">
        <property type="protein sequence ID" value="ORX15204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846217.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24580"/>
    <dbReference type="EnsemblBacteria" id="KWX24610">
        <property type="protein sequence ID" value="KWX24610"/>
        <property type="gene ID" value="AFM11_07980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15204">
        <property type="protein sequence ID" value="ORX15204"/>
        <property type="gene ID" value="AWC31_24580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5446"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="338" mass="39683" checksum="A4D056686E1EB1B0" modified="2016-06-08" version="1">MARTKMVRRWRRNMDVSDDTQYVDMLTTLSEGSVRRNFNPYKDIEWDSPEFAVVPNDPRWILPATDPMGGHPWYQAQPQERQIEIGMWRQANVAKVGLHFENILIRGLMEYSFWVPNGSPEYRYCLHESVEECNHTLMFQEMVNRIGKDVPGMPRLLKWLQPLIPLAAGPLPIPFFFGVLAGEEPIDHTQKNVLREGKSLHPIMERVMAIHVAEEARHISFAHQYLHKRVPHLRRRQRWLLSLFVPLTMRILCSAIIVPPRAFWKEFDIPRSVRKELFFGSPESRKMLRDMFGDVRMLCYDTGLMNPIAKLMWKICKIDGPPSRYRSEPQREHLVSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQS1</accession>
    <name>A0A132PQS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846259.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24655"/>
    <dbReference type="EnsemblBacteria" id="KWX24624">
        <property type="protein sequence ID" value="KWX24624"/>
        <property type="gene ID" value="AFM11_08055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5461"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031308">
        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="133" mass="14509" checksum="C0D6242221271C32" modified="2016-06-08" version="1">MRVILNIIWLIFGGLWLALGYLLAALISFILIITIPFGFASLRIASYALWPFGRTIVDKPGTRPGALIGNIIWVILFGWWLALGHLVSAVAMAITIIGIPLALADLKMIPVSLVPLGKDIVPVDRLNQQRVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRB9</accession>
    <name>A0A132PRB9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_08280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846951.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00170"/>
    <dbReference type="EnsemblBacteria" id="KWX24845">
        <property type="protein sequence ID" value="KWX24845"/>
        <property type="gene ID" value="AFM11_08280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5507"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="233" mass="25202" checksum="595451982989CB7A" modified="2016-06-08" version="1">MRPHRRSALLEQLMADPASPSQQAVLGELRRAILDGGVPPGTPIPLAEVAEVFGVSQIPVREALKTLIGEGLVAHRRNAGYSVALLTPAELREMYIVRETLESASLMVAVANASDADRAAAIAVNRLLEQAIADDDAAAYHRQSRQFHAALTRPSRMHRLLHMLEAAWNVTEPVQSMVHVGPADRAHLHADHREMLDAFLSEDPERLVAASEAHAARLNAVIATLPTDTGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRJ9</accession>
    <name>A0A132PRJ9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="15">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 19" type="primary">carB</name>
        <name evidence="19" type="ORF">AFM11_05915</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="15">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="15"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845145.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11775"/>
    <dbReference type="EnsemblBacteria" id="KWX24971">
        <property type="protein sequence ID" value="KWX24971"/>
        <property type="gene ID" value="AFM11_05915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4374"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 15" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="138"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="693"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="18">
        <location>
            <begin position="966"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="15">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="15">
        <location>
            <begin position="966"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="843"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="855"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="857"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KWX24971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1113" mass="119230" checksum="BA8DD3415345D884" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRR3</accession>
    <name>A0A132PRR3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AP endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845166.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29660"/>
    <dbReference type="EnsemblBacteria" id="KWX24985">
        <property type="protein sequence ID" value="KWX24985"/>
        <property type="gene ID" value="AFM11_06000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4391"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="31474" checksum="5D1F471F7660E0BD" modified="2016-06-08" version="1">MSVELVAARARLGLAPLTVLELSPPDMVSCAAAAGYHAVGLRLIRATADEPQRPTIGMTPLIRQTRERLDDTGIELRDIEVLRLTPTTRVRDDFEAFLETGAYLGAGEILVAGNDPDMSRAAANLAELAELADGYGLTPNIEPMPYNDVRDVTEAASLIERAGHRNIGLLIDPIHYYRGHNVLADLAALPASWFRYLQLCDAPTELPSSTEALVYQSRVARLLPGSGGLDLLALLLAIPPHTPVSVEAPVVAPGVPAVERAKAALHSTCRVLELADRIRDEYVDADTPVVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSB3</accession>
    <name>A0A132PSB3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_05620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845044.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12995"/>
    <dbReference type="EnsemblBacteria" id="KWX25236">
        <property type="protein sequence ID" value="KWX25236"/>
        <property type="gene ID" value="AFM11_05620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4314"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="296" mass="31259" checksum="7C41BD3B941D2E0F" modified="2016-06-08" version="1">MTFNEGMQIDTSTTSSSGGGRGPGRGIAIGGGIGGLLIVVLAMFLGIDPGTVMPQQQQMSTEGAEAQGFDLSQCKTGADANNIVQCRVVATGNSVDGVWQQLLKGYERPHVRLFTGQVNTGCGPATSDVGPFYCPVDQTAYFDTDFFQTLVDQFGSSGGPLAQEYVVAHEFGHHVQNLLGVLGRAQQDPQGPTGGGVRTELQADCYAGVWAHYASITRQESTGVPFLEPLSDKDIADALSAASSVGDDRIQQAATGRVNPEAWTHGSSAQRQKWFTEGYRTGDPNKCDTFATNDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSH2</accession>
    <name>A0A132PSH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843852.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25296">
        <property type="protein sequence ID" value="KWX25296"/>
        <property type="gene ID" value="AFM11_03115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2494"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="309" mass="33280" checksum="6B16D9FA900FF502" modified="2016-06-08" version="1">MELRTLRYFLAVAEERHFGRAAARIPVAQPALSQQILALEVALGVKLFDRSTRHVEITAAGRRLVEHARRIVEAADRARAEMTAFAEGKVGQVSVGLVGTATYDLLPRLTRLVRTELPGVDLQVRGELLSPQLLDSLEAGTVDLALVRPLSAEEPVAAPPAGGRGIVLERLRTEELLVVLPSTHPLAGYNVVDLSELRDETFIVHPSSARSFMHHHVLNVCARAGFRPALLEVSETATLAVTVAAGLGVAIAPEPVRTLGLDGVAYRRLRHRETVDLLLASRSSPTAPAITAVAAVIRRLAHATDRAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSL6</accession>
    <name>A0A132PSL6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_03475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844039.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21675"/>
    <dbReference type="EnsemblBacteria" id="KWX25351">
        <property type="protein sequence ID" value="KWX25351"/>
        <property type="gene ID" value="AFM11_03475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2569"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="234" mass="25856" checksum="AEEBFC363C3EA3F3" modified="2016-06-08" version="1">MSESRHQVIALQVADLIRDIQQNPPTDIDAALTELTESGVTYIPAAQHGGITIASSDGKLHTVAATSEVATLLDKIQQRCGEGPCLTAAWEQHVTKIDDVEIEQRWPAYCRDAREETPVRSIMAFQLYADNKTMGALNYYAEEPYAFDADAIEAGLIVATHTALAWNLLRRDQQFRSALASRDIIGQAKGMMMERYKIDAVQAFEVLKKLSQSSNTPLAEVAREVIQSEHPVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSP9</accession>
    <name>A0A132PSP9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844092.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21565"/>
    <dbReference type="EnsemblBacteria" id="KWX25369">
        <property type="protein sequence ID" value="KWX25369"/>
        <property type="gene ID" value="AFM11_03590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2593"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="244" mass="25142" checksum="6B5E68BC6F2BBA5F" modified="2016-06-08" version="1">MSHPGPSDADSPDQDDHTRILRRQPDGFPSGPVSKPLPSSDDPKTSIIRRHPTGAIPTAADAEPQTSLIGDPAGGEAQTGLIGPTAVSDAQTGLIGRPADDARTGYIPRARPIAIPRTSANTNPRSAVAASVVSILSGWATGVIATDLIAGWWRTDALFCVAIGFLAAISAAATIGGLIALLLRRRMGRLLIVVGAIIGLLIFGSLFIAGAKFHPVVYAMPILPAASIGLTLLPSTGRWAGSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT50</accession>
    <name>A0A132PT50_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844550.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25519">
        <property type="protein sequence ID" value="KWX25519"/>
        <property type="gene ID" value="AFM11_04570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2793"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008691">
        <property type="entry name" value="LpqH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05481">
        <property type="entry name" value="Myco_19_kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453266" evidence="1">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="152" mass="16138" checksum="15DAEB6EC4235627" modified="2016-06-08" version="1">MRGVTAGAAVALAAALLSAAGCASGPVSDVTIVVDGRTHTVSARVSCTKFPDGKLLIYAAPSKFDATKRVRVLLGTQHRLVVYAAGFRLPEVRGFGDDPGEMVATKVDDAYNISGRLPPEDGQLEWRQFEIDVTCPGYSQPARDQHPRLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT66</accession>
    <name>A0A132PT66_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845804.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11635"/>
    <dbReference type="EnsemblBacteria" id="KWX25242">
        <property type="protein sequence ID" value="KWX25242"/>
        <property type="gene ID" value="AFM11_05775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4346"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="275" mass="28779" checksum="B1A6236A1B81BECB" modified="2016-06-08" version="1">MHSAKCVQRGADELWLWEDCFLQGGIAQAAVALAATDTLTVGLGVLPTPLRNVVSTAMEIATLATMFPGRIRVGVGHGVQSWMHQAGAAVSSPLTLLREYVSALRDLLAGRSVTVEGRYVRLDGVQLEWAPQAPVPVLIGGTGPKTLQLAGVIGDGVIVDSENTVDSARAALDHVAAGRARRDDAGSFATVQYLACAPGPDGRRLLAEEAEKRDVPEDSYGVGGTVDEIAGAVAAYLGQPEHTVVLQPVGPDVDMDAFATTVREVVAHIRATDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTE8</accession>
    <name>A0A132PTE8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_04940</name>
        <name evidence="8" type="ORF">AWC31_20210</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FBPase class 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844684.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20210"/>
    <dbReference type="EnsemblBacteria" id="KWX25585">
        <property type="protein sequence ID" value="KWX25585"/>
        <property type="gene ID" value="AFM11_04940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16382">
        <property type="protein sequence ID" value="ORX16382"/>
        <property type="gene ID" value="AWC31_20210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2869"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX16382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="342" mass="35856" checksum="3D4A9B081273CD17" modified="2016-06-08" version="1">MSPTRGEAPDRNLALELVRVTEAGAMAAGRWVGRGDKEGGDGAAVDAMRELVNSVSMRGVVVIGEGEKDNAPMLYNGEEVGNGDGPECDFAVDPIDGTTLMSKGMPNAISVLAVAERGAMFDPSAVFYMNKIAVGPEAVDAIDITAPIGENVRQVAKAKGLSVSDMTVCILDRPRHEQLIADVRDTGARIRLISDGDVAGAISACRPHSGTDMLAGIGGTPEGIIAAAAIRCMGGAIQAQLAPKDDEERQKAVDRGYDLDEVLVTEHLVSGENVFFCATGVTDGDLLKGVRYASGGCTTQSIVMRSKSGTVRMIEAYHRLSKLNEYSAIDFTGDSSAIQPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTG5</accession>
    <name>A0A132PTG5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein Vsr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_05205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Vsr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844771.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="REBASE" id="146309">
        <property type="entry name" value="V.MwoCDC01ORF5200P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25626">
        <property type="protein sequence ID" value="KWX25626"/>
        <property type="gene ID" value="AFM11_05205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2923"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00221">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004603">
        <property type="entry name" value="DNA_mismatch_endonuc_vsr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03852">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00632">
        <property type="entry name" value="vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF559" evidence="7">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="143" mass="16006" checksum="286108BD01D8DE4D" modified="2016-06-08" version="1">MAKSWASSDHARRSMQGNRSRDTAPELAVRKLVHAMGLRYRVNARPLPALRRTADLVFTRRRVAVFIDGCFWHGCPEHHRQPSANADYWIAKVARNRARDAATDEALSAAGWTVLRFWAHQPPSEVAEAVRAAVTDEPGHSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTN5</accession>
    <name>A0A132PTN5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04260</name>
        <name evidence="3" type="ORF">AWC31_20895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844906.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20895"/>
    <dbReference type="EnsemblBacteria" id="KWX25696">
        <property type="protein sequence ID" value="KWX25696"/>
        <property type="gene ID" value="AFM11_04260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16746">
        <property type="protein sequence ID" value="ORX16746"/>
        <property type="gene ID" value="AWC31_20895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2730"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="117" mass="12527" checksum="C157C574AA3663F1" modified="2016-06-08" version="1">MGHGVEGRATPAASLDAASAAKVAETLQALASPNRLLILTRLRESPCTVTELSAAVGMEQPAVSNQLRLLRALGLVSGDRSGRNIVYRLYDNHVAQLLDEAIYHIEHLRLGARDTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTQ1</accession>
    <name>A0A132PTQ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844916.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20775"/>
    <dbReference type="EnsemblBacteria" id="KWX25700">
        <property type="protein sequence ID" value="KWX25700"/>
        <property type="gene ID" value="AFM11_04370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2750"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="136" mass="15443" checksum="A8D9B3C0DF42A2A5" modified="2016-06-08" version="1">MPVKDHPNNAPGMPMLFPAWIDRLQMKYMNPVARRFARFLPTFAVIYHRGRKSGRTYETVVQAYRKGNVLAILLGHGQTDWVRNVLAAGEAHVRRSNHDLHITEPRVVPMGTHAEGLPWIARLGSRRMAVLVANIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTQ5</accession>
    <name>A0A132PTQ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844942.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20180"/>
    <dbReference type="EnsemblBacteria" id="KWX25716">
        <property type="protein sequence ID" value="KWX25716"/>
        <property type="gene ID" value="AFM11_05050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2891"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="340" mass="36440" checksum="43484C4731FE2462" modified="2016-06-08" version="1">MVVKTLADAGRRVVATDLDVPANRKAAAELPAGVEMRWADLTDAAAVDALVAAVSPAAIIHLAAIIPPFCYMRRGLARKVNVDATASLLRAAAAQPEPPRFVQASSVAVYGARNPHRISDVLTPDTPVNPADIYGAHKVEAEGLVRASELDWLILRLGGVMSSQFSVDMDVDLISFESVLPADGRLQTVDVRDVAAAFMAATTVETTREVLLIGGDSATHRHTQSVVGSQAAAAMGISGGLPIGRSGNPDDDAAWFATDWMDTSRSQEVLRFQRHTWPQLLADTRANAGWKRYPIGLAAPLIRAFLRSKSAYKDYPGEYADVWNAIDKKWGDHRPDGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTY1</accession>
    <name>A0A132PTY1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">AFM11_00240</name>
        <name evidence="7" type="ORF">AWC31_33350</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003883485.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A132PTY1"/>
    <dbReference type="STRING" id="59750.AWC31_33350"/>
    <dbReference type="EnsemblBacteria" id="KWX25765">
        <property type="protein sequence ID" value="KWX25765"/>
        <property type="gene ID" value="AFM11_00240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11576">
        <property type="protein sequence ID" value="ORX11576"/>
        <property type="gene ID" value="AWC31_33350"/>
    </dbReference>
    <dbReference type="GeneID" id="61163202"/>
    <dbReference type="GeneID" id="66969249"/>
    <dbReference type="PATRIC" id="fig|59750.3.peg.49"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX11576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="101" mass="11433" checksum="76FF1CDC3DDE0DF6" modified="2016-06-08" version="1">MAGQKIRIRLKAYDHEAIDASARKIVETVTRTGASVVGPVPLPTEKNVYCVIRSPHKYKDSREHFEMRTHKRLIDILDPTPKTVDALMRIDLPASVDVNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTZ4</accession>
    <name>A0A132PTZ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842065.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33225"/>
    <dbReference type="EnsemblBacteria" id="KWX25744">
        <property type="protein sequence ID" value="KWX25744"/>
        <property type="gene ID" value="AFM11_00115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.24"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="283" mass="29651" checksum="D38DE833A5B34641" modified="2016-06-08" version="1">MAAGSGSLEGRVAFITGAARGQGRAHAIRLANEGADIIAIDVCAAVDDTITYAPATSQELAETVSAVEATGRKVLAREVDIRDLAAQQQVVADGIEQFGRLDIVVANAGVLSWGRLFEMSPEQFDTVIDVNLNGTWRTIRAAVPAMIEAGNGGSIIIVSSSAGLKATPGNGHYAASKHGLVALTNALALEVGEYGIRVNSIHPYSINTPMIEPEAMAQVFAKYPSYLHSFAPMPLHPVGLDDEGRSTFMTPEEVSDVVAWLAGDGSATLSGSQIAVDRGVMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU15</accession>
    <name>A0A132PU15_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNAase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844890.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21110"/>
    <dbReference type="EnsemblBacteria" id="KWX25687">
        <property type="protein sequence ID" value="KWX25687"/>
        <property type="gene ID" value="AFM11_04045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2687"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="284" mass="30380" checksum="3112478643BF2B38" modified="2016-06-08" version="1">MSSKRSARDKPPAPDPLTPLVDAHTHLDACGAETADDVRAILDRAAAVGVQQVVTIADDLASAHWVTTAADADERVYAAVALHPTRANALTDDAKADLERLAAHPRVVAVGETGMDMYWPGRLDGCATPAEQRDGFAWHIDLAKRSGKPLMIHNRDADAEVLDVLRAEGAPETVIFHCFSSGPDMARTCVDAGWVLSLSGTVSFKNAHELREAARLIPAGQMLVETDAPFLTPHPYRGAPNEPYCLPYTVRALAELLDRPAEEVASETAATAARVYGLNGSCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUH0</accession>
    <name>A0A132PUH0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844899.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20980"/>
    <dbReference type="EnsemblBacteria" id="KWX25692">
        <property type="protein sequence ID" value="KWX25692"/>
        <property type="gene ID" value="AFM11_04175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2712"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453644" evidence="1">
        <location>
            <begin position="31"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="167" mass="17327" checksum="D360F80B4098C664" modified="2016-06-08" version="1">MDIKKLAVTTTTAGALGLGALGLGTGLAQAEPNVPAPPPIPGPAVPDVDVPDVNVPDVDVPDVNVPDVDVPDVNLPDVNVPDVNVPDVEVPTVQFPEVDNFFGLPNGHIPPGQLKNSPTINGVANPFFGIPPGELKKLPTVNGIVNPFFDEVPGHWVIPDDPFPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUI1</accession>
    <name>A0A132PUI1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01485</name>
        <name evidence="2" type="ORF">AWC31_34455</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842796.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25973">
        <property type="protein sequence ID" value="KWX25973"/>
        <property type="gene ID" value="AFM11_01485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11765">
        <property type="protein sequence ID" value="ORX11765"/>
        <property type="gene ID" value="AWC31_34455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.303"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="73" mass="7971" checksum="4EC4731EDFE48673" modified="2016-06-08" version="1">MAELNPQPLPPRDRIRISAPDSVLFDLKKFQKAQAEVLGKAGCPGCHSGLDLQWQTFADFVVDEEGFAAPNMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUK1</accession>
    <name>A0A132PUK1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842375.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25847">
        <property type="protein sequence ID" value="KWX25847"/>
        <property type="gene ID" value="AFM11_00700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.143"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="33"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="326" mass="34357" checksum="2790C96AED9A93C9" modified="2016-06-08" version="1">MKNIYFPSHGVRCAAWHLPAQTDALAGVGGRPCVVMAHGFSGTRDSGLQSFAKPIAAAGIDVLVFDYRGFGDSEGTPRQDVSVKRQREDVHAALAAARHLPGVDSDRFALWGYSYGGGHAIAVAAQDRSVAAIVSMNPATDGVATLAHLAHNGEAGLLARLTAHGLLDTVRARTGRAPHTVPAVGRPGSTAFVTAPGVAEAFGGVAGPTWRNEISARHALEVGLNRPTIYASRLACPILVQVGTNDTVAPPDAARRTAKKAGYLAYLCEYPIDHVQAFDAPWQEKVLADQLEFLTRVLAPARVGDAHLRSGTESARTSGLVLKLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUN8</accession>
    <name>A0A132PUN8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_02155</name>
        <name evidence="9" type="ORF">AWC31_34935</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843101.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34935"/>
    <dbReference type="EnsemblBacteria" id="KWX26068">
        <property type="protein sequence ID" value="KWX26068"/>
        <property type="gene ID" value="AFM11_02155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11845">
        <property type="protein sequence ID" value="ORX11845"/>
        <property type="gene ID" value="AWC31_34935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.442"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="133"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX26068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX11845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="203" mass="22744" checksum="67F495C8CF49C296" modified="2016-06-08" version="1">MTSVQIVSAVDVESDAELAARFEREAMPFRPVLLRTARRLTHSDVDAEDLVQDALMNAYVGFRKFRQGTNLRAWLFRILHNRWISTYRMKQRRPDTFCVDEITDSDIASSAIHSDTGGRSAEDEALDVLGDHQIRVALQALPEGFQRVLYYADIEGYTYAETAVLMGIPLGTVMSRISRGRERLRAALSDHELAQPAVAACAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUP9</accession>
    <name>A0A132PUP9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842131.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33335"/>
    <dbReference type="ESTHER" id="9myco-a0a132pup9">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25762">
        <property type="protein sequence ID" value="KWX25762"/>
        <property type="gene ID" value="AFM11_00225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.46"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007356440" description="Carboxylic ester hydrolase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="COesterase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="530" mass="55602" checksum="CDCE3761D0F7F24B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUZ9</accession>
    <name>A0A132PUZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_02780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35560"/>
    <dbReference type="EnsemblBacteria" id="KWX26171">
        <property type="protein sequence ID" value="KWX26171"/>
        <property type="gene ID" value="AFM11_02780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.572"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453612" evidence="3">
        <location>
            <begin position="24"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="217" mass="23999" checksum="0DABB005E8D36F9D" modified="2016-06-08" version="1">MLKNVKTRLVSLLSVTRGSRAKAELLDAAERLIAEHGYDVPLREIALAAGQRNNSAVNYHFRNRQELVDAVVTRRLLPMEIEREQMLGELGDSESADVHALLRVLVLPLVNVEATHYARFLDVVRPRLPAEPQRAGESAWPRVLDALSHAVPTSDRRLQHRRVSAVATAMFALIAERERQSQDADRTPEDPEEIVGMLAAMLTAPLIAPACPSPRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV69</accession>
    <name>A0A132PV69_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33540"/>
    <dbReference type="EnsemblBacteria" id="KWX26213">
        <property type="protein sequence ID" value="KWX26213"/>
        <property type="gene ID" value="AFM11_00425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.86"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="456" mass="46959" checksum="1AFFC8FAEED2B796" modified="2016-06-08" version="1">MAAPGRTVVDTAALVRSGELAAVTVVQEALRRIESVDGVLGAFVHVDAERALDRARAVDEMVARGADPGPLAGVPLGVKELHPVQGWPYAMGSTLYADRIADHTCTLVARAVEAGAVPLGLTASPEFGRASFTASALHGVTRNPWNPELTPGGSSGGSAAAVAAGMVPIATGTDGAGSLRIPASYCGLVGFKGTYGLVPRGPRHRGVADNDHYGALTRTVRDTARFLDSVCGVDSYDRASLPAPARFEDNLDADLRGLRVAFATDLGNAPCDPHVAEAVQTAAEKFIAATGAQRVTADLRIDDRCGAAFRTLSAPDVHAQLRDLSPGATVHPTLRGYLDAAAGLDADALADAHEARAQLVATVAEAFERFDLLLTPATQVPAFGAQGPMPTEIAGQPVNHWGALAVTFPFNLTGQPAVSVPAGRVGGAPVGQQIVGRRHADLLVLAAAAAMEDIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV83</accession>
    <name>A0A132PV83_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26268">
        <property type="protein sequence ID" value="KWX26268"/>
        <property type="gene ID" value="AFM11_01835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.377"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="120" mass="13358" checksum="631D47BDF82781EC" modified="2016-06-08" version="1">MDRLVDTLAPGAELVSPLSGRMVFRGREDLRLLLAEVYGGLRDLRWQEVIGDGRTRVAVSEARIAGITITDALVFELDDTGRIMRLRPHLRPLLAIAVFALLLGPKIARHPAAVRRALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB52</accession>
    <name>A0A132PB52_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859642.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19565">
        <property type="protein sequence ID" value="KWX19565"/>
        <property type="gene ID" value="AFM11_35080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5744"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="59" mass="5734" checksum="B5BB1924909A217F" modified="2016-06-08" version="1">MAGDPNGVDVTETATDPALTDAIRAHAAEVTGFVTDGMPAMMGPMMGGGMMGGGGMMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB73</accession>
    <name>A0A132PB73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_34920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859548.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02100"/>
    <dbReference type="EnsemblBacteria" id="KWX19591">
        <property type="protein sequence ID" value="KWX19591"/>
        <property type="gene ID" value="AFM11_34920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5713"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="84"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX19591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="639" mass="65944" checksum="32D9AF4CFC1C54CC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBK8</accession>
    <name>A0A132PBK8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_34705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859414.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19684">
        <property type="protein sequence ID" value="KWX19684"/>
        <property type="gene ID" value="AFM11_34705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5288"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="3">
        <location>
            <begin position="291"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="412" mass="45456" checksum="9BE7F5C2381451A0" modified="2016-06-08" version="1">MSSEPASFAAEGSTCERLEVLFDEVAQLCGQRNAIDGRLVEIVAEIERDELWGATGARSMSALVAWKTGVTPRNADTMMAVARRLDEFPRCAEAMRQGRLSLDQVGVIAERAADGSDAHYAQLAAAATVNQLRTAVKLEPHPDPKPRPEPKREITKDVHDDYTTYRITLPRVEAAKLDTAMQSHHDAQIADWKRDHENCEQAPPFPNTVDAFMSLVEAGWDTDVAARPHGQHTTVVVHVDIDKRIAALHLGALLTDEERQYLTCDATCEAWFERHGHVIGAGRATRTVNRRLRRALEHRDRCCVVPGCGATRGLHAHHIIHWEDGGLTELANLVLVCPHHHRSHHHGEITITGPADQLIVTDHAGQPLRGGSLAQPPTTPPPAVPPCPGPTGERADWWWYEPFQPQPPPSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBL7</accession>
    <name>A0A132PBL7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19723">
        <property type="protein sequence ID" value="KWX19723"/>
        <property type="gene ID" value="AFM11_34335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5209"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="132" mass="14493" checksum="661578A8FEB6446C" modified="2016-06-08" version="1">MVTINARDGLTILDRAARNVNHAAVEAHRRDEAARATSERINVLRHIVFRNSTRGHRSVAALTSEPAAARLLVSASNSADGFLVLAIVRVAIDNRWGDVVNAGVRYFEAFEEHPIAARIQELWNLTTGRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBZ6</accession>
    <name>A0A132PBZ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="14" type="ORF">AFM11_33700</name>
        <name evidence="15" type="ORF">AWC31_08055</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858941.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08055"/>
    <dbReference type="EnsemblBacteria" id="KWX19851">
        <property type="protein sequence ID" value="KWX19851"/>
        <property type="gene ID" value="AFM11_33700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10351">
        <property type="protein sequence ID" value="ORX10351"/>
        <property type="gene ID" value="AWC31_08055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5076"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="49"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="210"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX19851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX10351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="284" mass="30197" checksum="D12A49446D8F8EF3" modified="2016-06-08" version="1">MLRVAVPNKGALSESAAEILAEAGYRRRRDPKDLTVVDPANNVEFFFLRPKDIAIYVGSGQLDLGITGRDLAADSDAPVRERLSLGFGASTFRYAAPAGRDWTPQDLAGKRIATSFPNLVRKDLAAQGIDATVIRLDGAVEISIQLGVADVIADVVGSGRTLGLHNLVAFGAPLCESEAVLIERDGADGDAAAAARDQLTARVQGVVFGQQYLMLDYDCPRAVLEQATAVTPGLESPTIAPLADPDWVAVRALVPRRDVNSIMDEIAAIGAKAILASDIRFCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCI6</accession>
    <name>A0A132PCI6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Secretion protein EccB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_33010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858407.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32455"/>
    <dbReference type="EnsemblBacteria" id="KWX20026">
        <property type="protein sequence ID" value="KWX20026"/>
        <property type="gene ID" value="AFM11_33010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4933"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX20026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="518" mass="53706" checksum="B7746C9A2B313978" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCP2</accession>
    <name>A0A132PCP2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LEH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20111">
        <property type="protein sequence ID" value="KWX20111"/>
        <property type="gene ID" value="AFM11_32280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4785"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013100">
        <property type="entry name" value="LEH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07858">
        <property type="entry name" value="LEH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LEH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="117" mass="13201" checksum="54D24B7B7E55338B" modified="2016-06-08" version="1">MAAWATNDVDEVMRNFADDATFDIGPDWPKLSGREAIYDLMEVFFGRGQVVDLEIRHLAVDGDVVLMERFDHWIMEGTPLSWPVMGAYQVREGKVVAWREYFWPADGDPGFGSAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCZ1</accession>
    <name>A0A132PCZ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857946.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32020"/>
    <dbReference type="EnsemblBacteria" id="KWX20203">
        <property type="protein sequence ID" value="KWX20203"/>
        <property type="gene ID" value="AFM11_31785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4684"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="489" mass="51913" checksum="6035F9C454705718" modified="2016-06-08" version="1">MNFDEYREYDATGLAELVADKQVSPKELLTLAQERASAVNPRINAIVRDVPAEPADGRSGPFAGVPFLIKDLAQDYAGLPTSAGSRAQMSLRASEHSTIVQRWLDAGLVIFGKTNTPEFGAKGITESVAWGPARNPWDLTRTPGGSSGGSAAAVAAGIVPCAGANDGGGSIRIPAACCGLVGLKPGRGLTPFGPGTAESMHGAAVQGVVSRTVRDTAAMLDVISGSEPWGPYVAAAPDSSYASCVRTAPGKLRIGVRVPSAITPAPHREAVAAVEGTMRALTELGHHVEELPQAPFDDAALARDFLLTWFVYAAWELEEAKRLTGAGDESFERDTLIMAALGRSTSSVDYVDAVQRRQEHTRRLSTFFESYDLLLTPTLATPPPKVGEFDLPAVLQLAADALLKTRLARLLRYTKIIDDMVDKNLGWVPYTQLANLTGRPAISLPLHWTADGLPLGVQFVAPLAGESLLIQLAAQLEQALPWAERIAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDK7</accession>
    <name>A0A132PDK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857348.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26910"/>
    <dbReference type="EnsemblBacteria" id="KWX20413">
        <property type="protein sequence ID" value="KWX20413"/>
        <property type="gene ID" value="AFM11_31200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4145"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="94"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="280" mass="30267" checksum="67B2FD6C1AD7E3F6" modified="2016-06-08" version="1">MTTAGCEHSWLPRASCDASCVHAGSADAGRRPVVWVRTTVRVAMAILLAPGVPLLAVPMPGRSHIQRFYCRLMLRCFGVRISVSGGPIRNLQGVLVVSGHVSWLDIFTIGAVLPGSFVARADLVEWPAVGRLARIMKVIPIDRGSLRRLPAVVHTVAERLRAGHTVVAFPEGTTWCGLAYGPFRPAMFQAAIDAARPVQPLRLNYRHRDGRPSTTPAFVGEDTLLQSIKRVITARRTVCHIHVGSLQLPGDDRRALAARCEAAVRSEQLLPSAPAHALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDN4</accession>
    <name>A0A132PDN4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20445">
        <property type="protein sequence ID" value="KWX20445"/>
        <property type="gene ID" value="AFM11_30135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3921"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="206" mass="21409" checksum="F35A9DE39702F313" modified="2016-06-08" version="1">MAKAEPVADGPDPAIARVGRAVADRRLALGMATQRDLADKAGVALNTAAFLERGRTFPREGNQRKLEVALQWPPGTLRSMLHDASSPAHAATAAPPVDEPIVHARVGSAPSSGSARPATVHTLSIASAVAAIATKSIAILLRTAGADDPETGTTLRELDGRLLELETIIAASLPHASADAFDETMSALADVHRQREALKDAARQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDZ5</accession>
    <name>A0A132PDZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29595</name>
        <name evidence="4" type="ORF">AWC31_24935</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856458.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24935"/>
    <dbReference type="EnsemblBacteria" id="KWX20559">
        <property type="protein sequence ID" value="KWX20559"/>
        <property type="gene ID" value="AFM11_29595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14450">
        <property type="protein sequence ID" value="ORX14450"/>
        <property type="gene ID" value="AWC31_24935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3810"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453229" evidence="2">
        <location>
            <begin position="34"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX14450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="141" mass="14915" checksum="EEC681028579439E" modified="2016-06-08" version="1">MNAVVKRAWLPILIVVAIAIGAVAVSNLRSVFGSDGAVVTPVGADTAQKFNPKVVVYEVFGTGTTATVNYMDLQGLPQRVESASLPWTLRLETTIPSVQPNLMVQGNGDSISCRVTVDDEVKDERTAHGVNAATYCLVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEQ1</accession>
    <name>A0A132PEQ1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="9" type="ORF">AFM11_28740</name>
        <name evidence="10" type="ORF">AWC31_32970</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856248.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32970"/>
    <dbReference type="EnsemblBacteria" id="KWX20816">
        <property type="protein sequence ID" value="KWX20816"/>
        <property type="gene ID" value="AFM11_28740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11510">
        <property type="protein sequence ID" value="ORX11510"/>
        <property type="gene ID" value="AWC31_32970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3626"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="8">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX11510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="262" mass="28168" checksum="90F3AD0951DE1E83" modified="2016-06-08" version="1">MTTFDGDETLADETAESEDVVEATETAEAESVDETDAAPAADEAAATEAPAADEDEDPAVALKKELRLKPGDWYVIHSYAGYENKVKANLETRVQNLDVGDYIFQVEVPTEEVTEIKNGQRKQVNRKVLPGYILVRMELNDESWGAVRNTPGVTGFVGATSRPSPLSLDDVVKFLLPQGAAKKPAKAAAAASAASTEATLERPEILVDFEVGESVTVMDGPFATLPASISEVNAEQQKLKVLVSIFGRETPVELTFNQVAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PET4</accession>
    <name>A0A132PET4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_28515</name>
        <name evidence="5" type="ORF">AWC31_32770</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856153.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32770"/>
    <dbReference type="EnsemblBacteria" id="KWX20784">
        <property type="protein sequence ID" value="KWX20784"/>
        <property type="gene ID" value="AFM11_28515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11478">
        <property type="protein sequence ID" value="ORX11478"/>
        <property type="gene ID" value="AWC31_32770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3581"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452999" evidence="2">
        <location>
            <begin position="27"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="SGL" evidence="3">
        <location>
            <begin position="84"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX11478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="378" mass="41410" checksum="14AF312F57CDDC50" modified="2016-06-08" version="1">MYTTRRNLLLGAAATVAAAMATSACSESSPPQSLPQLPASPPEPSSFRPNLRYPDPAVEILDPSFAKYRIYSSTLEQVGTGMRWAEGPAYFPDGGYLLCSDIPNNRIMKFDENDGTLSVFRSPANYANGNARDRQGRLVTCEHSATRRVTRTEKDGEITVLADSFEGKRLNAPNDIVVKSDDTIWFTDPLFGINGEWEGSRAEPDQPTTNVYRVTPDKQITAVITDLVNPNGLAFSPDEKKLYVVEWKATPNRSLWSYDVANDGAVSNKTKLIDAADQGALDGFTVDRDGNLWCGWGSNGALQEQPTDVGGRQVYQLRGKPDDLDGVKVFNPQGKAIGFIRLPERCANLTFGGPENNRLYMAASHSLYALYVETHGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEZ3</accession>
    <name>A0A132PEZ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Formate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_27855</name>
        <name evidence="7" type="ORF">AWC31_10375</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855733.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10375"/>
    <dbReference type="EnsemblBacteria" id="KWX20906">
        <property type="protein sequence ID" value="KWX20906"/>
        <property type="gene ID" value="AFM11_27855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08903">
        <property type="protein sequence ID" value="ORX08903"/>
        <property type="gene ID" value="AWC31_10375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3445"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX08903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="284" mass="30591" checksum="B39A1DE7BFC3F933" modified="2016-06-08" version="1">MSYVNPPEFVTKMIDAGENKAFMSTRDTVIRAYMAGAILALAAAFAVTITVQTGNPLLGAVLFPVGFCMLYLLGFDLLTGVFTLVPLALLDKRRGVTVRSMLRNWSLVFVGNFAGAFTVAVMMAVILTYGFTVDPNEVGQRLGEIGSSRTVGYAEHGAAGMLTLFIRGVLCNWMVSTGVVAAMMSTSVSGKVIAMWMPIMLFFYMGFEHSIVNMFLFPSGLMLGGDFSVADYLIWNEIPTVIGNLVGGLAFVGLTLYATHARTGSDWNRPAAPEEFKLPAEANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF50</accession>
    <name>A0A132PF50_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855856.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10670"/>
    <dbReference type="EnsemblBacteria" id="KWX20943">
        <property type="protein sequence ID" value="KWX20943"/>
        <property type="gene ID" value="AFM11_28125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3500"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="245" mass="26841" checksum="53CFA7F2EDD81769" modified="2016-06-08" version="1">MGPTLSPPESLEEIGSGPGGAQVGAFFDLDGTLVDGFTATAHARHRIRQRQAAFGEILGIIEASIRYRIGRMPFERLLVRAAGYLRGESLAELDDLGELLFAERFAHRVYPHMRDVVRRHQDRGHTVVMSSSALTIHAEPVARHLGIDDVLCNHFETDENGRLTGGIVKPVIWGARKADAVQAFCAANDIDLQHSYFYADGPEDSALMQVVGHPRPVNPRPGLATAAANNGWPVLTLDRPVARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF84</accession>
    <name>A0A132PF84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_28055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855823.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10575"/>
    <dbReference type="EnsemblBacteria" id="KWX20934">
        <property type="protein sequence ID" value="KWX20934"/>
        <property type="gene ID" value="AFM11_28055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3486"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="210" mass="20960" checksum="39E35EA76D3928BC" modified="2016-06-08" version="1">MFAIATLMALVQQVSGTPYISGGDSPAGTDCSGLASWVSNVATGRPAFGDRFNTGNQERALLARGFKHGTQPGALVIGWNSGHTAVTLPDGTPVSSGEGGGVKIGGGGAYQPQFTHHMYLPVQAEPAAPPPPPAPLPFGVPPPPEAPLPPVPPPPPPAPIAAPAPVDPFAPPPPPPADPMAVPASFVLNVPPPPGPPAPELPPPPPGMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFB6</accession>
    <name>A0A132PFB6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proline hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855262.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06870"/>
    <dbReference type="EnsemblBacteria" id="KWX21039">
        <property type="protein sequence ID" value="KWX21039"/>
        <property type="gene ID" value="AFM11_27020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3277"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018655">
        <property type="entry name" value="DUF2086"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09859">
        <property type="entry name" value="Oxygenase-NA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="237" mass="27394" checksum="29C8F0AA5B5E9498" modified="2016-06-08" version="1">MTDRWQKRVDSGDWDAITAEVDEFGGALLPRLLTDAETQRLQAMYGDDHRFRSTVDMGRHRFGEGEYRYFDLPYPEPIEQLKQALYPRLLPIAREWWTRLGRRPPWPDTLDEWLQMCHRAGQTKPTAILLRYAARDWNALHRDLYGDLVFPLQVVINLNKPGEDYTGGEFLLLEQRPRAQSRGTAMQLPHGHGYVFTTRDRPVRSARGWSAAPVRHGVSVIRSGERTTLALVFHDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFI7</accession>
    <name>A0A132PFI7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20752">
        <property type="protein sequence ID" value="KWX20752"/>
        <property type="gene ID" value="AFM11_29415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3774"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="151" mass="17147" checksum="9FC289B9DF442F56" modified="2016-06-08" version="1">MGTLARLFLSSPVHCRQLLDTLIYRYTHDTLHTELRADMEDFAVSIARQHALDQEPEYRAARGDVQRLRRHLQADADRAEERRREVATLRAESLAQTTLIAELRAELAHPTIPMLETSDGGTRDAPWGGDPGVRMSRQQRRAAARAAHKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFK3</accession>
    <name>A0A132PFK3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="13" type="ORF">AFM11_27465</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855483.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07400"/>
    <dbReference type="EnsemblBacteria" id="KWX21110">
        <property type="protein sequence ID" value="KWX21110"/>
        <property type="gene ID" value="AFM11_27465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3367"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453049" description="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase" evidence="10">
        <location>
            <begin position="37"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="12">
        <location>
            <begin position="126"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="11">
        <location>
            <begin position="349"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="425"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="425"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="128"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX21110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="512" mass="52200" checksum="6C3F4BC38AEEF3F9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGA3</accession>
    <name>A0A132PGA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854646.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35840"/>
    <dbReference type="EnsemblBacteria" id="KWX21379">
        <property type="protein sequence ID" value="KWX21379"/>
        <property type="gene ID" value="AFM11_26060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3076"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040611">
        <property type="entry name" value="TetR_C_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18556">
        <property type="entry name" value="TetR_C_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="207" mass="22643" checksum="9D7D1CDF7396FF1C" modified="2016-06-08" version="1">MSRPRDKQRIPYAEASRVLLRDSILDGMRDLLLTRDWSAITLSHVAQAAGVSRQTIYNEFGSRQGLAEGYAMRLADRLVDAVDDAINHNVGDVHAAFLEGFRSFFVDSAADPLVISLLTGASKPDLLQIITTGSGPIISRCSDRLTGTFQNSWMKASDEDAGVLARAIVRLAMSYVSMPPEADHDVAGDLARLMTPFAERYGVIEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGC5</accession>
    <name>A0A132PGC5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854718.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36235"/>
    <dbReference type="EnsemblBacteria" id="KWX21399">
        <property type="protein sequence ID" value="KWX21399"/>
        <property type="gene ID" value="AFM11_25660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2996"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="28146" checksum="078E2C266A9CF2F7" modified="2016-06-08" version="1">MTRVLAVANQKGGVAKTTTVASLGAAIAEKGRRVLLVDLDPQGCLTFSLGQDPDKLPVSVHEVLLGEVEPSAALVATDEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKLESDFDVVIIDCPPSLGVLTLNGLTAAHDVIVPLQCETLAHRGVGQFLRTISDVQQITNAELKLLGALPTLYDSRTTHSRDVLLDVADRYELPVLAPPIPRTVRFAEASASGSSVLAGRKTKGALAYRELAEALLKHWKSGKKLPTFTPEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGF3</accession>
    <name>A0A132PGF3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853975.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26985"/>
    <dbReference type="EnsemblBacteria" id="KWX21429">
        <property type="protein sequence ID" value="KWX21429"/>
        <property type="gene ID" value="AFM11_24730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2307"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="355" mass="38902" checksum="7CE538AD598B4050" modified="2016-06-08" version="1">MTFDPILSPMLLFVVGIVLIVIRMFALYRVLVRTGTGQYRRVVLRWCGLTLAVLMLVFAAARPGFDLDDGEQPEQPQGTLAVDPNLNVFFLVDRSVNSRVEDFGDRETRMTGIRADIESLINEYPRARFGVISFASKAVLDWPLSDDSWSLNSMVHGMSPYTLVAPDAMYQTDPTAARDVLKQQLEAAATRFPDSKSLVFYFGEGGGGSRVDDAPFDLPDGAVTGGAVLGYGTPAGGPIPQGWVDGTKVYQSDPGTGAPLNSVLDESKLKEIAEELGVPYFHREAGQPITAVLPAVDLSTTSADDENAVKASKFVERRELFWVFTMLAAILVLVEIALTIREFRRNRMSRKDVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGL5</accession>
    <name>A0A132PGL5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854098.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27235"/>
    <dbReference type="EnsemblBacteria" id="KWX21471">
        <property type="protein sequence ID" value="KWX21471"/>
        <property type="gene ID" value="AFM11_24980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2357"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="314" mass="34383" checksum="1926C00E60F5CBC6" modified="2016-06-08" version="1">MSNDSTAAAKAVKKTVPAAGAVLWRRSGEPVGDEPAPIEVAVIHRPRYDDWSLPKGKLESGETEPLTALREVAEETGYTAQLGRRLGAVTYPIQQGTKRVWYWAAKATGGDFTPNGEVDKLVWLPIDAAMEQLQYPYDRKVLQRFISHPPETKTVMIVRHGTAGSKAGYKGDDRKRPLDKHGRAQAESLVDQLLAFGATTLYAADRVRCHQTVEPLAQELGVEVHNEPLLTEEAYSSDREAARGRVLDIAARAGTPVICTQGKVIPDLIAWWCERANVRPETSGNRKGSTWVLSLSGGELVAADYMCSALPKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGM9</accession>
    <name>A0A132PGM9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="15">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="15">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="15">AP lyase MutM</shortName>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mutM</name>
        <name evidence="15" type="synonym">fpg</name>
        <name evidence="19" type="ORF">AFM11_25125</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854163.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27445"/>
    <dbReference type="EnsemblBacteria" id="KWX21495">
        <property type="protein sequence ID" value="KWX21495"/>
        <property type="gene ID" value="AFM11_25125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2386"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="15">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="15">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="15">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KWX21495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="285" mass="31881" checksum="4A5184FC40228A53" modified="2016-06-08" version="1">MPELPEVEVVRRGLQEHVAGRSITAVRVHHPRAVRRHEAGPADLTARLLDARITGTGRRGKYLWLTLDETEALVVHLGMSGQMLLGPIRDDRHLRIAAVLDDGTALSFVDQRTFGGWQLADMVTVDGTDVPQPVAHLARDPLDPQFDRERVVTVLRHKHSEIKRQLLDQTVVSGIGNIYADEALWRSKINGAKIAASLPRRRLGELLDASAEVMREALGQGGTSFDSLYVNVNGESGYFERSLDAYGREGEPCRRCGAVMRREKFMNRSSFYCPKCQPRPRVVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGY2</accession>
    <name>A0A132PGY2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_23910</name>
        <name evidence="10" type="ORF">AWC31_24245</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853484.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24245"/>
    <dbReference type="EnsemblBacteria" id="KWX21586">
        <property type="protein sequence ID" value="KWX21586"/>
        <property type="gene ID" value="AFM11_23910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15661">
        <property type="protein sequence ID" value="ORX15661"/>
        <property type="gene ID" value="AWC31_24245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2140"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007356432" description="Glucanase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 7">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX15661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="325" mass="33664" checksum="DBEF1E46F744310A" modified="2016-06-08" version="1">MSSAAGAVARWILPFLAVAMVFAAAPTQVGSGPAVRLASDGNPLVGMPFYVNPNSKAMRASKSDPSPELAAIANTPTAYWMDHISTPSVDAKYIADAQAAGTMPILALYGIPHRDCGSYAAGGFGSADAYRGWIDGVAAAIGGGRAAVILEPDALAMADCLSADQRQERFDLMRYAVDTLTRNPGTAVYVDAGHPRWVPAPDMAARLNEVGVAKARGFSLNTANFFTTEESTGYGEAISGMTNGAHYVIDTSRNGLGPVDSDSWCNPPGRALGVPPTTATASPHADAYLWVKRPGESDGSCGSGEASAGTFVNQYAIDLARNAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHB4</accession>
    <name>A0A132PHB4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23595"/>
    <dbReference type="EnsemblBacteria" id="KWX21739">
        <property type="protein sequence ID" value="KWX21739"/>
        <property type="gene ID" value="AFM11_24525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2266"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="152" mass="16532" checksum="44B4418C8B9FFBB3" modified="2016-06-08" version="1">MLITGMSGVGKSTVLAELARRGYETVDTDYGDWIHVVDEEPLWREPDIEALLGRPRTGPLFVLGTVANQVDFYPRFAAVVLLSAPRDVIFHRLRTRTGNDFGKTAADLARITGDIDEIEPLLRASATHELDTTRSAAEVADALVAIADAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHH6</accession>
    <name>A0A132PHH6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_23345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853139.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28070"/>
    <dbReference type="EnsemblBacteria" id="KWX21790">
        <property type="protein sequence ID" value="KWX21790"/>
        <property type="gene ID" value="AFM11_23345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2024"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="331"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX21790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="453" mass="48332" checksum="7272EE39FA97F30C" modified="2016-06-08" version="1">MRCTVFGTGYLGATHAAGMAELGHEVIGVDIDPGKVAKLAAGDIPFYEPGLRKVLNDNLAAGRLRFTTDYAEAADFADVHFLGVGTPQKKGEYGADLRHVHAVVDALVPALRRSAVIVGKSTVPVGTAADLAERARRLAPAGVDVEVAWNPEFLREGFAVHDTLHPDRIVVGVQKDSGPHARRTKDSRAEAAVRELYAPLLDDGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAADADVTLLADALGYDPRIGRRFLNAGLGFGGGCLPKDIRAFMARAGELGANHALTFLREVDSINMRRRTAMVELTTRVCGGSLLGSNIAVLGAAFKPESDDVRDSPALNVAGMLQLNGATVNVYDPKAMENSQRVFPTLNYSTSVVEACDRADAVLVLTEWAEFVDLDPAVLADTVRAKVIVDGRNCLDTKRWEGAGWRVYALGRAANSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHL0</accession>
    <name>A0A132PHL0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_23585</name>
        <name evidence="7" type="ORF">AWC31_28310</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX15031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853261.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28310"/>
    <dbReference type="EnsemblBacteria" id="KWX21830">
        <property type="protein sequence ID" value="KWX21830"/>
        <property type="gene ID" value="AFM11_23585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15031">
        <property type="protein sequence ID" value="ORX15031"/>
        <property type="gene ID" value="AWC31_28310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2073"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX15031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="209" mass="22623" checksum="869ACF05D6D3EDAB" modified="2016-06-08" version="1">MAPPAQTARKRGRRQGEPVSREAVLAAAKERFATDGYEKTTLRAIAADAHVDPSMVLYLFGSKADLFRESLQLILDPALLVEALEGPADDVGTRMVRRYLHIWESPETAASMRAMLQSATSNTDAHEAFRSFMQDYVLTAVSGVLGGGEQARLRAMLAASSLVGTAMLRYVMAVPPLATLTGDEVMRLIGPTVTRYLTADADELGLPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHT5</accession>
    <name>A0A132PHT5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_23490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853212.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28215"/>
    <dbReference type="EnsemblBacteria" id="KWX21814">
        <property type="protein sequence ID" value="KWX21814"/>
        <property type="gene ID" value="AFM11_23490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2053"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="29181" checksum="27BA6C450DAB396D" modified="2016-06-08" version="1">MTSGVAVRTPAVRVPPPPGAQRLRAAAVRLGALGWTVAGLVLAAAVWSLVVATGRFPRQLFPSVPEILAAGQTLWAEGLLADDISASLRRAAVGFAIGAVIAVIVAVFTATTAVGRNLLQPVLRVFSPIPTIGLVPLAILWFGLGENSKTLVIALGVFVPVWINSHSGIVSTPIDYLKAARCLGAGRWQTLRKVVLPEAAPDIAAGLRVGAAMAFVLIVVAEMTGTTAGIGYRIYQAQLFSQADRLIFCLVVLGIVGAICDLLVNAATSPVTRWAREEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHY1</accession>
    <name>A0A132PHY1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22550</name>
        <name evidence="2" type="ORF">AWC31_08655</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852759.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08655"/>
    <dbReference type="EnsemblBacteria" id="KWX21945">
        <property type="protein sequence ID" value="KWX21945"/>
        <property type="gene ID" value="AFM11_22550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10225">
        <property type="protein sequence ID" value="ORX10225"/>
        <property type="gene ID" value="AWC31_08655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1860"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="101" mass="11186" checksum="4E93A487BA19F38D" modified="2016-06-08" version="1">MVTYRNPGPISFDAVIEKPDRPGAYVEFPFSSVELFGVRARVPVHVRFDDTVDYTGSLAPYGGRHILGVRKEIQDTLGKSHGDTVHVELSLDTDRAEVAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI05</accession>
    <name>A0A132PI05_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22750</name>
        <name evidence="3" type="ORF">AWC31_08450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852828.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08450"/>
    <dbReference type="EnsemblBacteria" id="KWX21980">
        <property type="protein sequence ID" value="KWX21980"/>
        <property type="gene ID" value="AFM11_22750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10189">
        <property type="protein sequence ID" value="ORX10189"/>
        <property type="gene ID" value="AWC31_08450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1902"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="248" mass="27359" checksum="61521E365C1F8546" modified="2016-06-08" version="1">MSPSQRTLVIIPTYNERENLPLIVGRVHHACPEVHILVVDDGSPDGTGKLADELALADPDRVHVMHRTSKAGLGAAYLAGFEWGLGRGYSVLVEMDADGSHAPEELSRLLDAVDAGADLAIGSRYVPGGTVRNWPWRRLALSKTANTYSRFLLGVDIHDITAGYRAYRREVLEKIDLSAVDSKGYCFQIDLTWRAINNGFTVVEVPITFTERELGVSKMSGSNIREAMFKVAEWGIRGRLDRARGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI28</accession>
    <name>A0A132PI28_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853313.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28395"/>
    <dbReference type="EnsemblBacteria" id="KWX21847">
        <property type="protein sequence ID" value="KWX21847"/>
        <property type="gene ID" value="AFM11_23675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2091"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="214" mass="23464" checksum="71CA3E488206FDF8" modified="2016-06-08" version="1">MTEHVGPTEWGESPGVGPWVGPLPDDPRYDPELLRTGDTRNVVDAYRYWSREAIIADIDQRRHRLHIAIENFGNDANIGAVVRTANAFAVDTVHIVGRRRWNRRGAMVTDRYQRLRHHDTTAELLEFADGAGLTVVAVDNVPGAVRLEETELPRDCLLVFGQEGPGITPEAQAGAAVTVSIAQFGSTRSINAGVAAGIAMHAWITRHADISEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ65</accession>
    <name>A0A132PJ65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852243.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06640"/>
    <dbReference type="EnsemblBacteria" id="KWX22351">
        <property type="protein sequence ID" value="KWX22351"/>
        <property type="gene ID" value="AFM11_21275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1601"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="247" mass="24927" checksum="77421A7A000BABD4" modified="2016-06-08" version="1">MTTALVGRRALVTGGSRGIGAGIVRRLAADGAAVAFTYGASAVEAEKLVAELTADGAKAVAIQADAADPAQVAAAVEQAVAELGGLDVLVNNAGTAHMAPIDEFPQEEYDRVVAVNIGGVYSAIRSAVGHLGEGSRIINIGSINADRVPTGGTAVYAMTKGAVSSLTRALARELGPRGITVNNVQPGPIATDLNPDEGEFADVVRQTTALGRYGHTDDIAAVVSFLAGPESGYVTGANWNVDGGFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ99</accession>
    <name>A0A132PJ99_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="4 8">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_19940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4 8"/>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851870.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28575"/>
    <dbReference type="EnsemblBacteria" id="KWX22428">
        <property type="protein sequence ID" value="KWX22428"/>
        <property type="gene ID" value="AFM11_19940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1322"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="9">
        <location>
            <begin position="185"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="192"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="484" mass="51581" checksum="6FBD3E7ECEB05539" modified="2016-06-08" version="1">MTNTSTSGTAQIGVTGLAVMGSNIARNFARHGYTVALHNRSVAKTDALLAEHGSEGKFVRSETIAEFLDALEKPRRVLIMVKAGEATDAVINELADAMEEGDIIIDGGNALYTDTIRREAAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYKSLGPLLEEISAHVDGVPCCTHIGPDGAGHFVKMVHNGIEYSDMQLIGEAYQLLRDGLGKSAGEIADVFDEWNKGDLDSFLVEITAKVLRQTDAKTGKPLVDVIVDEAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVPQRKATVGLASGDLGAAPADAAQFTEDVRQALYASKIVAYAQGFNQIQAGSAEYDWNITPGDLATIWRGGCIIRAKFLNRIKEAYDVEPDLATLIAAPYFRSAVESAIDSWRRVVVTATQLGIPIPGFSSALSYYDALRTERLPAALTQGLRDFFGAHTYGRIDAEPGQKFHTLWSGDRSEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJE2</accession>
    <name>A0A132PJE2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851898.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28430"/>
    <dbReference type="EnsemblBacteria" id="KWX22456">
        <property type="protein sequence ID" value="KWX22456"/>
        <property type="gene ID" value="AFM11_20085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1353"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453124" evidence="1">
        <location>
            <begin position="31"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="234" mass="24436" checksum="EDF1DF996D440F5A" modified="2016-06-08" version="1">MRHPWLRALRSLVLAAPLAVLLHAAPMAQAMPGVLVYPGMEIRQDTNVCTLGYVDPVSRIGFTAGHCRGSGPVGDRNGNFIGQQTSFRDNTPDGATIDTNHMISDWETIQLAGDVAVNNILPGGRLLVEDPAVVPAPGLPVCHFGVVTGESCGTIEAVNNGWFTMAHGVVSQKGDSGGPVYVLTPDGRAAIVGMFNSTWGQYPAAVSWQSASGQARNAVVQASGDIANAVVPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJI1</accession>
    <name>A0A132PJI1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22172">
        <property type="protein sequence ID" value="KWX22172"/>
        <property type="gene ID" value="AFM11_22025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1753"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="147"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="28261" checksum="5EB8AF5381A174B4" modified="2016-06-08" version="1">MSAPIMLAVLASALMHAVWNSLAHAIPDRLVGFALIGLVDAVGGAVLAAIGGLPPAGAWPFIIASALAHVVYNLLLLASYQLGEFSQMYPLARGTSPWLVAVIAMVFLGREMPVTELIGVLTISAGLIGLVFLGGRPNRKDVPALGAALLTGVTIAGYTVIDGVGVQHSPLFAYAGWMFLLQGPPLAILAAVRRGPRLAGAVRESAVPGLAGGAISLAAYTIVLAAQTSGALAPIAALRETSIVFGALIGSVFLGEKLGARRAIAAGVVLAGVLLISLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJM7</accession>
    <name>A0A132PJM7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851840.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11115"/>
    <dbReference type="EnsemblBacteria" id="KWX22397">
        <property type="protein sequence ID" value="KWX22397"/>
        <property type="gene ID" value="AFM11_19775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1289"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="251"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="510" mass="54249" checksum="3939FC730D99F0F5" modified="2016-06-08" version="1">MTALLECTDIQKSFGGVPVLKGITLQLEPGTVTALAGENGAGKSTLMKIVSGQYSADHGTVSVQGNHLSTGNTRDAVKHGVAIVPQELASIEDMTVYENLFVGRELKRGPFLNRRAMIAEAKETLAVFDVGISPTARMGSLPVGLRQIVEIVKAARTGAKVVMLDEPTSAISEREVEGLYKIVRQLRDRGVAMVYTTHKMAEIRAIADRVVVLRDGGLILDKPIDGVSDDDIVTAMIGRELDTLFPERPKPGTDTVLEVRDLQVEGASGPVSFTVKAGEIVGLAGLVGAGRTELLEAIFGARHSSAGDVIVRGRAIKRNQPAAAITAGMAMVPEDRKLSGAVLSMSVLDNGTLPRLSSFSVAGWLRGKARTQAVSDVMSSVRLRSRGLGQEVGTLSGGNQQKVVLARWLTGDVNVLLLDEPTRGVDVGARSEIYRIITEFAAQGMAVVMASSDMPEVVGLSHRAFVMRGGLLVGELDRDALDHPEVQESVFRLATALDAKEEQTSQEIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJT3</accession>
    <name>A0A132PJT3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Propanediol utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18965</name>
        <name evidence="2" type="ORF">AWC31_15055</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851577.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15055"/>
    <dbReference type="EnsemblBacteria" id="KWX22591">
        <property type="protein sequence ID" value="KWX22591"/>
        <property type="gene ID" value="AFM11_18965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17754">
        <property type="protein sequence ID" value="ORX17754"/>
        <property type="gene ID" value="AWC31_15055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1127"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003207">
        <property type="entry name" value="Ppandiol/glycerol_DeHydtase_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036091">
        <property type="entry name" value="Prodiol/glycerol_DeHase__sf_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02287">
        <property type="entry name" value="Dehydratase_SU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47148">
        <property type="entry name" value="SSF47148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX17754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="110" mass="12048" checksum="B64B768C418FF2F3" modified="2016-06-08" version="1">MSEKFTVEAAVDGKLELADLRMDPAVLAHQAVIAEENGNPQLAENFLRAAELATIDDEDVMNLYEALRPHRSTAEDLAALRASLEGRGATRCAELVRQAADVYARRGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK14</accession>
    <name>A0A132PK14_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrile hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851750.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15565"/>
    <dbReference type="EnsemblBacteria" id="KWX22675">
        <property type="protein sequence ID" value="KWX22675"/>
        <property type="gene ID" value="AFM11_19480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1229"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018822">
        <property type="term" value="F:nitrile hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042262">
        <property type="entry name" value="CN_hydtase_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024690">
        <property type="entry name" value="CN_hydtase_beta_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008990">
        <property type="entry name" value="Elect_transpt_acc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02211">
        <property type="entry name" value="NHase_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50090">
        <property type="entry name" value="SSF50090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHase_beta" evidence="1">
        <location>
            <begin position="42"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="278" mass="31680" checksum="6479BD99532BA95E" modified="2016-06-08" version="1">MSTAAERAAHLDLVGRLKSGYPEIPDAPTPDLLDHERFLAYMKTVHDVGGEPDAPMKYENKDYEYWEHMTYVMCEVLGWRGIWLSEERRRIGNVDVGRAIYQGFPYYGRWLWAVARVLVQKHHISLGELTSRMAEVKGRYEGGLNGRKLEAQPKSEGDGADVKRNEHHIRAVGIGDPQVYAGKAGQPKFKVGDAVVVRELPVLLYTRTPEYVRGARGEIAEVTYESPAAEDETWDRADAPPEWFYIVRFNQAELWHGYTGTTSDTLQTEIPERWLENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK20</accession>
    <name>A0A132PK20_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851771.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15625"/>
    <dbReference type="EnsemblBacteria" id="KWX22688">
        <property type="protein sequence ID" value="KWX22688"/>
        <property type="gene ID" value="AFM11_19555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1244"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453414" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4185" evidence="2">
        <location>
            <begin position="54"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="376" mass="40026" checksum="BF9C1B49FE179E7B" modified="2016-06-08" version="1">MARWFSAAAVLIAASVWQAPVVHANPPEPWPEPVLPKLAPGQVLRIGPIAGTGTPTGDYGIGATDLCEFMEFPSRVLQVCGDSFAGQAVGFGGWYSPIALHVESDSIDDPAGVRYDGVSGVDKPLLADATPPGGSQLPAGVVAINRENYMMVTTTRNLVPQTSRLVKADAAQGNWPTIAGSARDASYLGGAQSQISGYYDPIPTPDSPRGWVYIVANNFDRSGPVFLYRATPQAFTDRAAWQGWSAAPGGGWGKPPTALWADRVGEMSIRQIDGKSVLSYFNASTGNMEMRVADDPTGLGTAPVTTVVVASEWPEPAEALPPPEVNRLAQPYGGYISPGSTLDEVRVFVSQWNTTPRGGTPYRVLQYVVNPIKPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK82</accession>
    <name>A0A132PK82_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851727.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15505"/>
    <dbReference type="EnsemblBacteria" id="KWX22664">
        <property type="protein sequence ID" value="KWX22664"/>
        <property type="gene ID" value="AFM11_19420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1217"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="391" mass="42562" checksum="683D19DB97EB3C66" modified="2016-06-08" version="1">MNTPLTTTDGAVRPTDEPGRRQALLPAPQVQNHAANLAVLPDGKLACVWFAGTQEGVPDICVWMSRLDGDAWSSPVQLSDDPTRSEQNPVLHVTESGAVWLMWTSQHAGNQDTARVLRRISTDGGASWGPVHTLIPETDEGGVFIRQPVVRLPSGRLLLPVFHCVKVPGHKWVGDHDYSAVMVSDDSGESWREVAVPCSTGCVHMNIGRLSDGTLVALYRSRWADAVYRSTSTDDGETWTAPVPTELPNNNSSIQFVVLPDDRLALVFNESSADDATDRRTSLYDEIDDDGLADAALAPVQPNEHLGRAFWGAPRAPMTLAISADAGLTWPVRRNVEIGDGYCLSNNSRDGLNREFSYPTITAAGGLLHIAFTRFRQAIEYVELADDWVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKA2</accession>
    <name>A0A132PKA2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17610</name>
        <name evidence="2" type="ORF">AWC31_05130</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851096.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05130"/>
    <dbReference type="EnsemblBacteria" id="KWX22769">
        <property type="protein sequence ID" value="KWX22769"/>
        <property type="gene ID" value="AFM11_17610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10666">
        <property type="protein sequence ID" value="ORX10666"/>
        <property type="gene ID" value="AWC31_05130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.877"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021408">
        <property type="entry name" value="DUF3046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11248">
        <property type="entry name" value="DUF3046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="64" mass="7184" checksum="A5C71B8751EF74D4" modified="2016-06-08" version="1">MRLTEFHDLVDGQFGSMRGRSLLVDHVLSGLGGRTAAQAIEDGVEPREVWRALCADFDVPRDQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKE0</accession>
    <name>A0A132PKE0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Baseplate J family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851179.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11935"/>
    <dbReference type="EnsemblBacteria" id="KWX22810">
        <property type="protein sequence ID" value="KWX22810"/>
        <property type="gene ID" value="AFM11_17865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.927"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011749">
        <property type="entry name" value="CHP02243"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02243">
        <property type="entry name" value="TIGR02243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="386"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="655" mass="71425" checksum="173A8005F7D81B8E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKF0</accession>
    <name>A0A132PKF0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17905</name>
        <name evidence="2" type="ORF">AWC31_11975</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036437200.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11975"/>
    <dbReference type="EnsemblBacteria" id="KWX22816">
        <property type="protein sequence ID" value="KWX22816"/>
        <property type="gene ID" value="AFM11_17905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18709">
        <property type="protein sequence ID" value="ORX18709"/>
        <property type="gene ID" value="AWC31_11975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.936"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="148" mass="16565" checksum="E5B4F8194010D4B0" modified="2016-06-08" version="1">MALQDDDSSVGHSFGLEFDGIQIKAITEVTGLKMEQDVIEYKSNMAKDGKYNVKKLPGRWKAGECTLTRPLTKDNGFEKWVKDSQLGKMKDARKGGSIIVFDYEGEEVKRYNLTAAWPKSLELSSMKAGDTSVMTEKLVLTYEKCEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKF7</accession>
    <name>A0A132PKF7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_17700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851125.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11820"/>
    <dbReference type="EnsemblBacteria" id="KWX22783">
        <property type="protein sequence ID" value="KWX22783"/>
        <property type="gene ID" value="AFM11_17700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.895"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013228">
        <property type="entry name" value="PE-PPE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08237">
        <property type="entry name" value="PE-PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453372" evidence="2">
        <location>
            <begin position="30"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PE-PPE" evidence="3">
        <location>
            <begin position="86"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="501" mass="52799" checksum="9EFDA87EA40FB886" modified="2016-06-08" version="1">MCATARSTVRALLVAILVLTSTVALGVTAAFSAAISAALGLVVATTPLVVPGTGTPDPADSNNYMAHAVAYYVETSGSCGDGCTAPVPVPYIAQFWPFPFEGWGGLQGAKWNVSVASGVASLNDQLDIAKPDSDHPVVIFGYSQGATVTSIVKRQLAEDYGGTIPDWIDFVVIGNPNRPNGGLFERLAALGTVPILDATFGEPTPTDTSDEVNTYDIALQYDGVADAPSWLLNPLALANALAGFEYTHPTYLAPDGDDLPTETPYGYTPQQVQAAIENAQESCTAETHCQERGDTRYITLPAKVLPIMQPFLDFAESTGTSALVVPIVDLVSPLAQTLIETGYDRRDYSKPTPFQLLPKVDPVKLVTDLAGDIPAGIDAALNPGLDPLPGWTDPTEDDDAAPAPDATVDDDAVPVTKQVTTRPDRKPLTRLSAIARPAEGLTQPEEGTETERPSLRKALGIKGHPVRDFAKSVQGSVRKALGHDDEKAADTKQSDASQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKS1</accession>
    <name>A0A132PKS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_18560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851373.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12585"/>
    <dbReference type="EnsemblBacteria" id="KWX22893">
        <property type="protein sequence ID" value="KWX22893"/>
        <property type="gene ID" value="AFM11_18560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1048"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="4">
        <location>
            <begin position="22"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="317" mass="35660" checksum="B56D6A3E228C04BF" modified="2016-06-08" version="1">MTDISERVKDHSPLTDTGLDVVPLAGYIGAEIRGVDLRGDLEPSVVEEIRGALHTHKVIFFRDQEIGHAEQIAFARRFGRVTPAHPHEEEPPEGFPEILPIDSRRYERHLGRKRTSYDNSWHTDVTALVNPPAASILRAHILPPYGGDTVWTNLVAAYENLPKELRDFADKLDIKHQFNTRAVAGSQRDRKVREANLVAYHPAVRVHPVTGERALFVSPGFTRGAREIRGFSPSQSEAILKLFWEEATRTEYTVRFRWAPGSVAFWDNRATAHLAIPDAGHLDYDRVLYRVTLEGDIPKGVDGRESELVSGEPFHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKW8</accession>
    <name>A0A132PKW8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850673.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22989">
        <property type="protein sequence ID" value="KWX22989"/>
        <property type="gene ID" value="AFM11_16575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.664"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="31"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="188"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="361" mass="37382" checksum="757040B732CCA0CA" modified="2016-06-08" version="1">MAGTSRVAVLYGPGDLRIEELALPALGADDGLLRVEATGVCGTDVAAYYGVNPYYELPCVLGHELVGRVVEIGHQASERWGVQQGDRIVVEEYLPCGTCRSCLAGAYQMCRVYRYGGKSIHAGSGLYGGYADYMYLHPQALVHKVAEDVDADLLQLYIPISNGLDWMSRIGALPIGGTAVIVGPGPHGLACVIGAVEAGADKVIVVGQDTDAHRLSVATQLGATHTVTGDTDDVVASVSEITGGLLADTVVNAADSSAALETALAVAGDRGTLVQVGLPKSGGGSAEPVLAALNSKVLTIRGVRGRPSSAVPPTLRLIESGKYPLHLLCTGQFTIEQTEEALTTNGRVPEAIRSSVIPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKX5</accession>
    <name>A0A132PKX5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12120"/>
    <dbReference type="EnsemblBacteria" id="KWX22837">
        <property type="protein sequence ID" value="KWX22837"/>
        <property type="gene ID" value="AFM11_18050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.966"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010219">
        <property type="entry name" value="UCP010219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="233" mass="25013" checksum="27FC4D6B6972205D" modified="2016-06-08" version="1">MSQAENGPGNAPPGPTSEPEPTSARPSTGGRAILDQMGGVSGLIYSTLPVVVFVPVSSAFGLMPAIAAALGVATLILIWRLIRRDSVQPAISGFFAVGISALIAYLVGESKGYFLLGIWTSLLWAVVFGVSVLIRRPVVGYVWGWVNSHDRGWRDVRKAVLAFDIATITWVLVFASRFLVQEYLYDADETGWLGFARIAMGWPLTAVAALVTYLAIRTAQRALHAHQAAQTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKZ8</accession>
    <name>A0A132PKZ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_16755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23019">
        <property type="protein sequence ID" value="KWX23019"/>
        <property type="gene ID" value="AFM11_16755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.704"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="149"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="221"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="436" mass="47836" checksum="20AAA943B1FA852B" modified="2016-06-08" version="1">MTEPGGTMTRQLHLNINVNSSGRHPASWRVADDPLGFLDLGFYEEIGRLAEAGRLDAVFFSDEFDYGAPSVSRPWQALDPIVPLTAVARVTEHVGLVATVSSSFEHPYTIARKIASLDYVSGGRAAWNVVTTRAPESARLFGYEEQPAHDERYGRAEESVRVAIALWESWDADALIADQASGKFADATRIRPVDFRGKYFRVDGALNVPRSPQGRPVVLQAGGSPQGVELAARHADAVFTVHHTVGAAREFYQTLKSKAAGYGRKPEDIVILPGLFPVLGSTEREAHDRKQWLDEVVGFDSELQSLSAILGLDVGDLRLDAQLPWYKIDSIASSRAGIGFASAVLELARAEQLTVRQLLQRNPNGHRSIVGTPEQVADSIEEWFTAGAADGFNLNTDFFPDGLRSIVEQLVPELQRRGLFRREYEATTLRGNLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL23</accession>
    <name>A0A132PL23_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipoprotein LppA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_16900</name>
        <name evidence="7" type="ORF">AWC31_01470</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850797.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01470"/>
    <dbReference type="EnsemblBacteria" id="KWX23046">
        <property type="protein sequence ID" value="KWX23046"/>
        <property type="gene ID" value="AFM11_16900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13229">
        <property type="protein sequence ID" value="ORX13229"/>
        <property type="gene ID" value="AWC31_01470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.733"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032018">
        <property type="entry name" value="LppA/LppB/LprP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16708">
        <property type="entry name" value="LppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453101" evidence="5">
        <location>
            <begin position="33"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX13229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="205" mass="22503" checksum="8799B75EB7083679" modified="2016-06-08" version="1">MVSRRRARSARRHAIALTFLVSTSMVIGGCSMTENPYESKTVKGEEAVKLIDSMREKGSYEQARERLNATAKVIAERIVAAVPGQTWKFSDDPNVQQVKASGLPCEKLTGDIAKRPMSDSVKFGRTFSTEEFAVANDVVREEAAQYGATGESSLFNEQAKRDFDIQGNGYEFNLGQSKFATLNITGDCFLLQSVVDLPPGQLPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLU4</accession>
    <name>A0A132PLU4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850329.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16050"/>
    <dbReference type="EnsemblBacteria" id="KWX23263">
        <property type="protein sequence ID" value="KWX23263"/>
        <property type="gene ID" value="AFM11_15715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7266"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="2">
        <location>
            <begin position="120"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="272" mass="27749" checksum="B35F082802B890B1" modified="2016-06-08" version="1">MTDERSREESTSSDPLAPLAALPGVAAASDEARDALGRAHRHKVNLRGWPQTAAEAALRAAKASAVLDGGSILPVGRSAATGGSALSEDGKPDPVTAGAIRVAEALEGGATSLVGVWQRAPLQALARLHALAAADLADDEHLGRPRTDPEVGPRLELLTEMLTGGSRVPAPILAAVAHGELLTLAPFGSADGVVARAVSRLVTIASGLDPHGLGVPEVHWMRKSGDYRAAARGFAAGTSDGLTAWLLLSCEALHAGAREALQIAQASLDRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLX8</accession>
    <name>A0A132PLX8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850479.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16745"/>
    <dbReference type="EnsemblBacteria" id="KWX23336">
        <property type="protein sequence ID" value="KWX23336"/>
        <property type="gene ID" value="AFM11_16140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7353"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453170" evidence="2">
        <location>
            <begin position="26"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="388" mass="40224" checksum="2D303D0BE21D95A1" modified="2016-06-08" version="1">MRAIAALMMGVLLLVGCGSPETPTASTTSAAPDDTGIDAQESKDPVTRLVLVEPGTGATVVFDAAEETETSLGEFGRTDGISGDGRFAYLRGADAITVVDGGSWTFDHGDHSHYYVEPAGLAGHLDGRFADAVGQRTLTVLRREDGTVDVLDRNALGEHRMTTVDGFGPLRDIAEIAPLGEDLVTVTRTGAISAVGPDGTAQPLGQCPDTTGASMVSGALIFGCADGAVRIAKRAGKLTADPMPFGNTRPATKLGRLSHRYGGSTLAAVTADEVWVLDGRRGAWASVRVPGAITANAVSGDSVLVLTADGQLRRFDTKTGTQAAAVPLFSGPVPSVEPTPVIEVDADRAYINDAAARVVYEVDYGDGLRLARTLKTSIAPGFMVETGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM84</accession>
    <name>A0A132PM84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01505"/>
    <dbReference type="EnsemblBacteria" id="KWX23152">
        <property type="protein sequence ID" value="KWX23152"/>
        <property type="gene ID" value="AFM11_16935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.740"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="807"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="873" mass="93298" checksum="A677302003B3DC89" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PME8</accession>
    <name>A0A132PME8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849897.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18235"/>
    <dbReference type="EnsemblBacteria" id="KWX23509">
        <property type="protein sequence ID" value="KWX23509"/>
        <property type="gene ID" value="AFM11_14665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7042"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="113" mass="12258" checksum="C6A309674E0B816B" modified="2016-06-08" version="1">MTGLADAVVARMARQRDLLAAMQEQCAAIRVRATSPDRAVTVEVDATGAMTDLTMGGAATRLGAQELANLIVNIAQTAAKAAVDRRDRLVEQFNSRYQEIEREPLRRSDDTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMF5</accession>
    <name>A0A132PMF5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase PknB</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_14485</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849839.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18340"/>
    <dbReference type="EnsemblBacteria" id="KWX23483">
        <property type="protein sequence ID" value="KWX23483"/>
        <property type="gene ID" value="AFM11_14485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7005"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031326">
        <property type="term" value="P:regulation of cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="11"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="12">
        <location>
            <begin position="353"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="12">
        <location>
            <begin position="420"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="12">
        <location>
            <begin position="488"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="12">
        <location>
            <begin position="555"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX23483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="623" mass="66411" checksum="3C5CFA8DF7F9D7C8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMX9</accession>
    <name>A0A132PMX9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemC</name>
        <name evidence="9" type="ORF">AFM11_12965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849159.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03250"/>
    <dbReference type="EnsemblBacteria" id="KWX23696">
        <property type="protein sequence ID" value="KWX23696"/>
        <property type="gene ID" value="AFM11_12965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6685"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="12"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="229"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="321" mass="33614" checksum="1A8127FF52874995" modified="2016-06-08" version="1">MANSSRTRDTPIRIGTRGSLLATTQAGTIRDALLAAGHPCELVIITTEGDRNQGPIADIGVGVFTAALREAIHDGRVDMAVHSYKDLPTARDERFTIAAIPRREDPRDALVARDGLVLGELPAGSVIGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVTSGDLDGIVVARAGLARIGRLNVVTETLEPVQMLPAPAQGALAVECRSGDTELVAVLSELDDADTRAAVIAERVLLAELEAGCSAPVGAIAEVVESIDEDGNVFEELSLRGCAATLDGSDVIRASGIGTPERAADLGVSVAAELFELGARELLEERGSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMY2</accession>
    <name>A0A132PMY2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein AFM11_12985</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12985</name>
        <name evidence="4" type="ORF">AWC31_03270</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849168.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03270"/>
    <dbReference type="EnsemblBacteria" id="KWX23699">
        <property type="protein sequence ID" value="KWX23699"/>
        <property type="gene ID" value="AFM11_12985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11158">
        <property type="protein sequence ID" value="ORX11158"/>
        <property type="gene ID" value="AWC31_03270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6689"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="178" mass="19707" checksum="9691A5E613A5120D" modified="2016-06-08" version="1">MSIAADIIGTHYRYPDYFEVGREKVREFARAVKDDHPAHYSDEAAAEYGHDSVVAPLTFLAVAGRRVQLELFDKFDVPINLERVLHRDQKLIFHRPIVVGDKLWFDSYLDSVIESHGTVICEIRAEVTDDDGNPIATSIVTMLGEAAHPDEADEISSQIAAARDAAIARMIAGQKSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN35</accession>
    <name>A0A132PN35_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849316.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23750">
        <property type="protein sequence ID" value="KWX23750"/>
        <property type="gene ID" value="AFM11_13295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6752"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453198" evidence="1">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="167" mass="18099" checksum="1084BEFA4AA74915" modified="2016-06-08" version="1">MMRRTGWVVLVVGLVVGTAVALGLGTWQMTEKNRPAPTLVADQTAARDEVVELTTANLEKLLSYTPRTDDDDVDNLAALLTGEAVDNYREQMRSKTAIARSNGVTQTSNVRNAAIETLSADKAQVLTFVDQIVESTGNKTRTEAQLAIRVELAQINGAWLITAINTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN40</accession>
    <name>A0A132PN40_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23617">
        <property type="protein sequence ID" value="KWX23617"/>
        <property type="gene ID" value="AFM11_12475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6585"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="38"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="281" mass="31230" checksum="5F9698ADBA820433" modified="2016-06-08" version="1">MMSEFTWPNGKAAAAAFTFDVDAESAVLWGNDAVAARMSVVSHQAYGPLVGVPRILDLLEHHQIAATFFVPGHTAHRYPEAVRSIVSAGHEVAHHGYLHEPPAQLTLEEEVEALDRGLEALAEVAGVVPAGYRAPMWELSWRTPALLAERGFLYDSSLMDSDHPYELEVGDSSLVEIPIQWALDDWEQYCYLPDISGSGLIESPRKARELWQLEFDALRRAGACWVLTNHPFLSGRASRAAELDDLMRYVLDHTDVWTTNLGAIAEHVRTLKLAPRTITRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNA9</accession>
    <name>A0A132PNA9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_13790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849505.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04030"/>
    <dbReference type="EnsemblBacteria" id="KWX23828">
        <property type="protein sequence ID" value="KWX23828"/>
        <property type="gene ID" value="AFM11_13790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6854"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="521" mass="55030" checksum="7BA95AB1E0331C50" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PND4</accession>
    <name>A0A132PND4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29810"/>
    <dbReference type="EnsemblBacteria" id="KWX23851">
        <property type="protein sequence ID" value="KWX23851"/>
        <property type="gene ID" value="AFM11_13925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6881"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="316"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="478" mass="52299" checksum="700D6CFFFF0A0635" modified="2016-06-08" version="1">MRHHTETPESSAMIERICSSSRRENREAAGRLAAVAELFAYRLSRSTESEDWAIDTTEVVAAEIAAALRISQELAVSMIGYARAMRERLPKIGALFEAGDLDLAMFRTLVYRTDLITDADVLAAVDAELAAAVPRWLSMVSRGHLAAKVDRIVKRHDSDAVRRRREAAAQREIWIHERLDGLADIGGTVSATDGRTLDQRLAALAATVCERDPRTQDQRRSDAVGALSIGADRIACQCGQPDCAAVGAPPASPVVIHVIAEQAALEGHSDVPGSFVEADGLIPAEQLPSLAESAKLRPLIHPGDAPAEPGYTPSRALAEFVRCRDLTCRFPGCDKSAETCDIDHTIPYDDGGPTQAANLKCLCRRHHLLKTFCGWRDKQLRDGTIIWRSPSGDIYVTTPGSALLFPTLCAPTAEVTERAIPDVRPRTAMMPRRTRTRAQNRAARIDAERRANRRDREPHYTYFAALPPPGSDVDPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNQ0</accession>
    <name>A0A132PNQ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848199.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30520"/>
    <dbReference type="EnsemblBacteria" id="KWX23969">
        <property type="protein sequence ID" value="KWX23969"/>
        <property type="gene ID" value="AFM11_11375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6352"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="439" mass="47343" checksum="8A3C7FF5DCB9DAF1" modified="2016-06-08" version="1">MYDPNLVAAPASASNPLRPAIAVVGSGPSGCYVAQFLAKQWADADITIFESLPAPYGLIRYGVAADHQGAKGVARQFDRMFTKGSVRFAGNVSVGRDIDFDLLAGSFDIVVLATGLPEDRPLGIPQEPGTRVIGAGALLRALNGFPSKTLPQDATGRHIPLGRRLAVVGMGNVAVDVIRLLSKDRDGFVGSDIDDELLRELRPAAPETIDVISRSAVTDAKCDTAMLREVVSLSNIDLEVTGLHEHDSGPTADLLRPFACSPAAAPGFDTHRTRVRLHFGAVPELIENSDGCTLLRARNRYGDHRPVDFAVDTLITAVGFTCGPSDDRCCPSQAWAGAHVYRVGWLSRGAKGTIPENRKDAQRIVGEIVKDAESRRIPLGRPGFRAVEALVGDRVVSFADWQRIEAYERRSAHPDRCRRKVVDLDKMIEIATAPVTSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNR8</accession>
    <name>A0A132PNR8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MmgE/PrpD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848276.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23989">
        <property type="protein sequence ID" value="KWX23989"/>
        <property type="gene ID" value="AFM11_11510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6378"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="3">
        <location>
            <begin position="25"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="4">
        <location>
            <begin position="291"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="483" mass="51215" checksum="38FC69108EAD3851" modified="2016-06-08" version="1">MGGMNALSTQPQVALPSAPDGPTGRLVDWVHTLGWDDIPDPVRRRATHLLLDGIGCGLIGAQLPWSRAAAKAVLGIEGAGTVPVIGTGRTTTPVGATLLNSTFIQGFELDDFHPLAPLHSASLLVPSLLATAAQMDRPVSGRELLVAAVAGFETGPRIGYALGGTEMLSRGWHSGPIFGGIASALACSKLRGLNGAQLEDAVGFAATQSAGLMSAQYEAMGKRMQHGFAARNGFYSAALAETGYTGIDQVLERPYGGFLAVYGEGHHIDADAITRGLGENWETTVIMVKSWAVMGGLHGVVEAARTLRERLGSRVIDRIDIRVGDVIYHHGWWKPQRPLTAIGGQMNIGYAAAVTLLDGVALPQQFTAQRLDADDVWQLLDRTHVELDRGIDELPMTERFQTHLSLTFSDGSTDTATVIAPHGYPGDPVTDDELVAKFHSLVEPVMPVERAAAIVRAVLGLPDMEDVAPLVDQLGGEVGRALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNV2</accession>
    <name>A0A132PNV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849572.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23867">
        <property type="protein sequence ID" value="KWX23867"/>
        <property type="gene ID" value="AFM11_12880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6668"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="20542" checksum="6881F2FB8E40172C" modified="2016-06-08" version="1">MAIGRPLGFDPDHVLEIAMTLFWEHGYDGVSISDLTAATGINRRSLYATFGSKEQLFYRAVDRYLAGPGGFVAAAMAQPTAWHVAYAMAHGAADAYTDPASPRGCLLVQGALASGADAAPVQADLADRRAAGVKLLAERFAMAQQAGELAGADPWIIARWINAVCQGISIQACSGATREELHAVADQALKAWPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNW7</accession>
    <name>A0A132PNW7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848428.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24039">
        <property type="protein sequence ID" value="KWX24039"/>
        <property type="gene ID" value="AFM11_11785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6436"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="221" mass="24520" checksum="F7A4FE41F3F0BA8C" modified="2016-06-08" version="1">MARILIAEDEPRISSFIEKGLSANGFAVTVVAEGGAAYDYAVTGGFDLMILDIGLPDIDGFSVLRKLRADRNPIPVIVLTARDSVQDTVAGLEGGADDYMPKPFRFEELLARVRLRLTSNRAAELTVLSYGGLQLDLRTRRARVGGDTVDLSAREFALVETFLRHPGQVLSREQLLSHVWGYDFDPGSNVVDVYVRYLRRKLGADRFVTLRGMGYRLEDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP21</accession>
    <name>A0A132PP21_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849409.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23782">
        <property type="protein sequence ID" value="KWX23782"/>
        <property type="gene ID" value="AFM11_13490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6793"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="354" mass="39417" checksum="DA7F24A872C810B7" modified="2016-06-08" version="1">MRVGLLQEGDLTGTTAYARYHQLIDEVALADRLGFSTWGTSEQHFSPPSFSIAAPEVLYAAIAMRTNRITLRTMASVMLKWNHPILVAERLATLDIVSNGRAEVCTARSNNLTTLGAFGVDPAETRDQWEDGMDVLMKAMTAEKLEHDGPVWQIPSVEVVPKPYTKPHPKVSVAASSAQTHSNAGKRGIGAITFDNYFGFDYLQECLDAYRTAFDESDHSAVAAPNDYRGLYVATAYCAESREEARAVARDIAMEYFKFILDLYIPLSKNPGYTYLDTLEQLIAHQDDLDWLCEYTPSVMIGTPDDFVERIRRIEAMGIDEVLLRIDGVGHENIKKSLELIGHEVIPVVDPSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP61</accession>
    <name>A0A132PP61_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848666.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09735"/>
    <dbReference type="EnsemblBacteria" id="KWX24120">
        <property type="protein sequence ID" value="KWX24120"/>
        <property type="gene ID" value="AFM11_12245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6528"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="142" mass="15407" checksum="43C8407415FB1EE8" modified="2016-06-08" version="1">MRLLKRFWIPLLITVVVVVGAFTVMRVRTFFGAGDGTGIASAKVDDTKPFDPKVVVYEIYGEPGAIADVNYLDLDAQPQRIDGVSLPWSLRLESTAPSVFPNIVAQGNGSSISCRITVDDELKDERTSNGVNAQTFCLVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPH8</accession>
    <name>A0A132PPH8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848631.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09810"/>
    <dbReference type="EnsemblBacteria" id="KWX24107">
        <property type="protein sequence ID" value="KWX24107"/>
        <property type="gene ID" value="AFM11_12165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6512"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032407">
        <property type="entry name" value="MHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038378">
        <property type="entry name" value="MHB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16525">
        <property type="entry name" value="MHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04529">
        <property type="entry name" value="MTB_hemophore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453471" evidence="1">
        <location>
            <begin position="36"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="MHB" evidence="2">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="126" mass="13010" checksum="BB3040EEC9C7CC60" modified="2016-06-08" version="1">MLLSARNARRVVAGAAGAGALAGAMLFGAVPSALAEPAPNPPNCTAADLAGVAAGVSASTSAYLFTHPDVNNFFTSLEGLPREEVRTKVHDYLEQNQQVKAELTGIRQPLVDLKNRCGTAPAPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPM2</accession>
    <name>A0A132PPM2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847336.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05350"/>
    <dbReference type="EnsemblBacteria" id="KWX24288">
        <property type="protein sequence ID" value="KWX24288"/>
        <property type="gene ID" value="AFM11_09875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6013"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="255" mass="27209" checksum="A0770C11A1730BEB" modified="2016-06-08" version="1">MTKPRTPLDAATAVLSDPTLPTGADERFVGFGVMGFPFASGHYLALRYFPATTFSPGYRSVWHRGPDGVWTFYATTPGQQSCARYFSSATPNDAVQCEIDVAWVNPWTLLVGIPGLLEWTVEIRSTASSRLVSAIGSALPTRSWTNPAMLDLIGRTAGTLLRAGTVQLAGKAPNGQHFMIAPTQVWLADGHAVLDGTELGPPGPLAEQAVLADFRPPQRGIFVVGSGHFDTFDATRHRAADRTVLFDGSAPDPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPM4</accession>
    <name>A0A132PPM4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFM11_09925</name>
        <name evidence="18" type="ORF">AWC31_05300</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847361.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05300"/>
    <dbReference type="EnsemblBacteria" id="KWX24296">
        <property type="protein sequence ID" value="KWX24296"/>
        <property type="gene ID" value="AFM11_09925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09652">
        <property type="protein sequence ID" value="ORX09652"/>
        <property type="gene ID" value="AWC31_05300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6021"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG-type" evidence="16">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KWX24296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX09652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="264" mass="29474" checksum="A9C32A19EFD0A3FD" modified="2016-06-08" version="1">MPEGHTLHRLARLHQRRFGRAPVAVSSPQGRFSDGAAAVNGHILKRASAWGKHLFHHYDGGRVVHIHLGLYGTFTEAPVPLPEPIGQVRMRMIGAEYGTDLRGPTVCELIAEPEIVDIVAKLGPDPLRADADPALAWKRITKSRRPIGALLMDQAVIAGVGNVYRSELLFRHRIDPHLPGTRLDQAEFDAMWTDLVELMKVGVRRGKIVVVRPEHDHGAPSYRTGRPRTYVYRRASEPCRVCGTPVRTMELEGRNLFWCPTCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPW9</accession>
    <name>A0A132PPW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847628.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18890"/>
    <dbReference type="EnsemblBacteria" id="KWX24380">
        <property type="protein sequence ID" value="KWX24380"/>
        <property type="gene ID" value="AFM11_10455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6131"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="177" mass="19129" checksum="ECBF8CF83F5E198B" modified="2016-06-08" version="1">MGFDKSVLPGTVCQIGYVVPDLDDAISGWLQMGVGPWFVIRGLSQRVTFRGEPCAVTLSMALSNSGDLQIELIQQLDDTRSVYTEFLGTTGGGFHQLAYWAPDFDGAMAKLDDAGWPKVWWGGEGDGVRFAYFEPPAGAAIVEIMELTDASQGMATFVRQAAARWDGSEPVRELTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ52</accession>
    <name>A0A132PQ52_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="5">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_10980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-malate + NAD(+) = CO2 + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847898.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24468">
        <property type="protein sequence ID" value="KWX24468"/>
        <property type="gene ID" value="AFM11_10980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6237"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="7">
        <location>
            <begin position="6"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="359" mass="38802" checksum="3153A05912E3267D" modified="2016-06-08" version="1">MTRAHRIAVIPGDGIGTEVVPEGLRVLDAAATAFDLKLDYAHFDHSSADYYLKHGKMLPDNWFEDLRTFDAIFFGAVGWPEVVPDHISLWGSLLQFRRAFDQYVNLRPVRLMPGVPSPLAGRKPGDVDFYVVRENTEGEYSSIGGKIFEGTDRETVMQETVMTRTGVDRILKFAFDIAQSRPKKHLTSATKSNGISISMPYWDERVDAMAAGYSDVEVDKYHIDILTANFVMHPDWFDVVVASNLFGDILSDLGPACTGTIGIAPSANINPERTFPSLFEPVHGSAPDIAGKGIANPIGQIWCASMMLEHLGEPAAAAAVLAAIETVLARGGDTLTPDMGGTASTETLGKAVADAVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQI8</accession>
    <name>A0A132PQI8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_10020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05205"/>
    <dbReference type="EnsemblBacteria" id="KWX24312">
        <property type="protein sequence ID" value="KWX24312"/>
        <property type="gene ID" value="AFM11_10020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6040"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004097">
        <property type="term" value="F:catechol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022739">
        <property type="entry name" value="Polyphenol_oxidase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12142">
        <property type="entry name" value="PPO1_DWL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="SSF48056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="7">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="8">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="491" mass="52609" checksum="55936F27A4546C64" modified="2016-06-08" version="1">MSALTTAAGADWPEELTKYRDAVAAMRQLDPPGNGKPTDPLSWSFQAAIHGRNRPSGGPDTSNRFWSNCQHGSWFFLAWHRMYLSAFETIVQHFLGDDDWSLPYWYAIDPDDEDKAVLPPAFRENTPGNALFTEMRSVPANSGDPLAFVEPGIPALIEALGTPLFNTADGIQTFGGGERATPAYNGGEQGLLEGVPHGLVHVLVGNDYDAIGNPIRFGWMGNFGTAALDPIFWLHHSNIDRLWQVWLDADDTHRNPTGDTAWMRTKFSFPKPGGGTVTWEIGDVLDTTALGYKYENVKPPSGLEPPEPAGGGRLDLGLGEGEPIPPLPPQVIGATVDVPMVGDERVDVAMSQPADIGLGERAAAERLLLRLEGITGTIAAPAYDVYIDVPEGASPPDFPERRAGTLTTFGVPEASRGTDEHDGTGLNAVFDISSVRDALADAGQWDPANLRVSFVPLVPSTSNQAALDAIAARAAPVTPDLHAARIVVLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQS3</accession>
    <name>A0A132PQS3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846421.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00240"/>
    <dbReference type="EnsemblBacteria" id="KWX24676">
        <property type="protein sequence ID" value="KWX24676"/>
        <property type="gene ID" value="AFM11_08350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5521"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="452" mass="49727" checksum="1EC64AF6B1E0181D" modified="2016-06-08" version="1">MAEATTDPVRLPPGPRIPKLVTGIAFLAARHRAVAAVGRRYDGAFTIDLPIFGEAVVVSDPALLKDLFTTNGDLVGRAANLGTVLGPGSTFSLDGDDHRARRKLLVPPFHGKRMAGYEAIVEEEVLRESAGWPEGREFATLEPMMRITLNAILRTVFGAQGQSLDELRELLPPMVPLASRMAVLPAALRRDLGPWSPWGRVQRSRRRYNEIVASLIAEARADPDFDSRSDVLALMLSARYEDGTPIADAHVADELLTLLAAGHETTATTLAWAIERLRRHPRLLARLTAEADAGGSELRQATIWEVQRTRPVIAATSRVARQRLRLGEWVVPEGHVVIASIALSHDSERNFRDVKTFDPDRFLGANPDTHTWIPYGGGIRRCIGAAFANMEMNVVLRTLLREFEFRTTYSPGERTHSRGIATAPSRGGLAVVYRRRGRSPVITNRAAEEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQX8</accession>
    <name>A0A132PQX8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07960</name>
        <name evidence="3" type="ORF">AWC31_24560</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000014">
        <property type="protein sequence ID" value="ORX15227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846930.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24560"/>
    <dbReference type="EnsemblBacteria" id="KWX24607">
        <property type="protein sequence ID" value="KWX24607"/>
        <property type="gene ID" value="AFM11_07960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15227">
        <property type="protein sequence ID" value="ORX15227"/>
        <property type="gene ID" value="AWC31_24560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5442"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="150" mass="16102" checksum="605FDC03C93AE0F7" modified="2016-06-08" version="1">MAIEVTPAVSPHLVVDDAAAAIDFYVKAFDATELGRVPGPDGKLIHAAVNINGSTVMLNDDFPEFSEGKSSTPKALGGTPVTIHLTVTDVDAKFARAVEAGAEVVHPLEDQFWGDRYGVVRDPFGHQWSLGQPVREVSMEEIEEAMKSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR83</accession>
    <name>A0A132PR83_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intersectin-EH binding protein Ibp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846704.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24774">
        <property type="protein sequence ID" value="KWX24774"/>
        <property type="gene ID" value="AFM11_08950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5639"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453259" evidence="2">
        <location>
            <begin position="39"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="118" mass="11645" checksum="DD87CEF41777F2AA" modified="2016-06-08" version="1">MTISQLSARRLIVVGGFAAAIAAAPAITAFTIPATALAACPSGETEDTFTGVCVPDLVPNSPEFTSAPGQLPQIDGIPCTGANSGQCIGLAEEQEAQGPQPVPQSTVGSSPTATGHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRA8</accession>
    <name>A0A132PRA8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13125"/>
    <dbReference type="EnsemblBacteria" id="KWX24869">
        <property type="protein sequence ID" value="KWX24869"/>
        <property type="gene ID" value="AFM11_09245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5697"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="365" mass="39336" checksum="0214EAD22B6F25FB" modified="2016-06-08" version="1">MTQVQPFIDDDELTGVTDVIKRNWLTEGTCAASFLEAIKQETGAPHAVLAPNGTLALFLALLALDLPRDGEIIIPAFTFYASASAAVFAGLRPVFADVDPETFNLTVDAFAEQITDRTVAVMPVHVYGHTAALDDIQDVAGQHGIKVIEDAAQAYGVNFNGRAAGTWGDVGAISFFADKTITTGEGGVVLTGNSELYERLRLLRNQGRLNSGTFKHDALGMNFRVTDLQCAVGLSQLRKLPDIAAAKRRNHARYVENLRGVEGIRTMRIQPGSDHLPFRFALLSEHRDAVVTALEAAGIQTRGFFYPLHMQPALTQYADGPLPNAEKLYSQGICLPVHTGLSAADIDEISGIIRGVHDDAHASGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRC1</accession>
    <name>A0A132PRC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08800</name>
        <name evidence="2" type="ORF">AWC31_13570</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846619.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24747">
        <property type="protein sequence ID" value="KWX24747"/>
        <property type="gene ID" value="AFM11_08800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18344">
        <property type="protein sequence ID" value="ORX18344"/>
        <property type="gene ID" value="AWC31_13570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5608"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="118" mass="13292" checksum="9B8840A621E04362" modified="2016-06-08" version="1">MDIDYNDQRLNDGLANLVDQQKAGKLSDFTSWDWDEVHLFHESVEREFIEETVGAPVIKSRFYDSKASLLVFELNGEPVKAAGISGDYLRGENHRVTFPADVMLDPQGGGYLMLTLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRC7</accession>
    <name>A0A132PRC7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_05435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845776.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12810"/>
    <dbReference type="EnsemblBacteria" id="KWX24889">
        <property type="protein sequence ID" value="KWX24889"/>
        <property type="gene ID" value="AFM11_05435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4276"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="94"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="439"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="703"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="779" mass="86240" checksum="72B7BC68ECEC7DD9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRI3</accession>
    <name>A0A132PRI3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845014.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12905"/>
    <dbReference type="EnsemblBacteria" id="KWX24905">
        <property type="protein sequence ID" value="KWX24905"/>
        <property type="gene ID" value="AFM11_05530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4296"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="29061" checksum="1E04C4A6EAEFFFDA" modified="2016-06-08" version="1">MTFTRTDVQNLVFDHAGTALTADVRPGTGTPILLVPGVMADAATWRPVVDSIDLPNPVITVNRRGRYPSGPLGADYSVRVEVDDLRHIIDALGDVHLFGWSYGALIALETALTCERIVSLTAYEPVSRPFAPDVVQPLRQAIAAGDLDRAVTLVNTDVSGFSADYVAELRRSPAWAVLRPLAGPLAEELAAINTHRPALDRYRTLPMPVRLILGTRNEGQAPYGTAFAAFADALPQAPVVPLADQGHLAHVEAPAALAALISAAVTAAEGRPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRZ1</accession>
    <name>A0A132PRZ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_06475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845318.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29200"/>
    <dbReference type="EnsemblBacteria" id="KWX25065">
        <property type="protein sequence ID" value="KWX25065"/>
        <property type="gene ID" value="AFM11_06475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4488"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="259"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="309" mass="33109" checksum="A15797C327325D07" modified="2016-06-08" version="1">MIELSSLTKAYQGVAALNDVSFSVPTGSVLALLGHNGAGKTTTVKILSTLIQPTSGRALVAGFDVVTQAGLVRQNIGVTGQEACLDQLLTGRENLTLFGRLHGLRRRQARERADELIDQFDLEHAADRSVQTYSGGMRRRIDIAVALVVPPKVLFLDEPTTGLDPRSRRQVWALVSSLAAQGVTVLLTTQYLEEADILSDSIVILDSGRVVASGTADDLKGQIGTSYCQVTLVRTADVARVAAVLADIDEIDADEETNTVSVRAADGVGTLSEVFRRLDQLGVELIDISLRKPSLDEVFLHLTPPALTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSC4</accession>
    <name>A0A132PSC4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06050</name>
        <name evidence="3" type="ORF">AWC31_29610</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845821.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29610"/>
    <dbReference type="EnsemblBacteria" id="KWX25246">
        <property type="protein sequence ID" value="KWX25246"/>
        <property type="gene ID" value="AFM11_06050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13969">
        <property type="protein sequence ID" value="ORX13969"/>
        <property type="gene ID" value="AWC31_29610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4402"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="150" mass="16301" checksum="53D656C6C57B93E6" modified="2016-06-08" version="1">MTADTWDVEIRPYRTPIFAYGAALIIFAAHVSVGALLKVGSTGVVFRTADQVAIALLGAVIACVVLMFARPRLRVGPSGVAVRNLVGYRTIPWSDVVDVSFPRGARWARVDLPDDEYIPVMAIQAIDKGRAVDAMDKVRELVAKYRTGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSE0</accession>
    <name>A0A132PSE0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845414.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28960"/>
    <dbReference type="EnsemblBacteria" id="KWX25107">
        <property type="protein sequence ID" value="KWX25107"/>
        <property type="gene ID" value="AFM11_06715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4542"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="154" mass="17556" checksum="6B6325F84E72EF15" modified="2016-06-08" version="1">MPLTASTLDTLRRSRYALLRTYRRDGTAVDTPIWFVLEGRTMLFRTKIGPKTRRITARPDVELVPCDYKGRVTGTDRVTGRATVLTGAEAQRGNRALHRRYGWQWNIVPVLKIPGVTNVHRDLPLREKLRRARDRNVWPDSAIVRIDLDGPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSX2</accession>
    <name>A0A132PSX2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate mutase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03550</name>
        <name evidence="3" type="ORF">AWC31_21605</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844861.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21605"/>
    <dbReference type="EnsemblBacteria" id="KWX25364">
        <property type="protein sequence ID" value="KWX25364"/>
        <property type="gene ID" value="AFM11_03550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16769">
        <property type="protein sequence ID" value="ORX16769"/>
        <property type="gene ID" value="AWC31_21605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2585"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010958">
        <property type="entry name" value="Chorismate_mutase_highGC-bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01808">
        <property type="entry name" value="CM_M_hiGC-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="87" mass="9728" checksum="C3A4810CA55897BF" modified="2016-06-08" version="1">MTETIDSVPDIDDLRREIDELDATILAAIQRRTEVSKEIGKARMASGGTRLVHSREMKVIERYSVLGPEGKDLAMLLLRLGRGRLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSZ2</accession>
    <name>A0A132PSZ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844432.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20930"/>
    <dbReference type="EnsemblBacteria" id="KWX25468">
        <property type="protein sequence ID" value="KWX25468"/>
        <property type="gene ID" value="AFM11_04225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2722"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="451" mass="49456" checksum="12878DDB858D3303" modified="2016-06-08" version="1">MHHLRKHAVVCGASMAGLLAARVLADFYESVTVVERDILPDNAIQRRGVAHGRHLQMMLSGGSSRLAHLFPGLFDELAAAGAHVMDGIDDPSLFYLRVGEHVACRSGRFTRSDDVVIVLASRPLLETHVRRRVSAFGNVTIMDSHDVIEPVLDSSCRISAARVADRETGAERMLEADLVVDATGRAGRTPAFLEARGYERPRERKYPVGLSYSSQFFRLPSGALTEKVAAVNDLVEKRRGAGVLAYEDGTAILTLIGVAGHKLPTDLPGVLDAATELLPPQFSSALRAAQPLGAVTAQHYPVSVWRRYDKLDRLPQGLLVIGDAVCSFNPVYGQGMTSAALQAMALRQCLSSADTTDIATRYFRTAAKKLAPIWWANRFTDFNFTPTDDWRTKPRRLLNRGMDRVWAALATDIVLAETFIRKLQLVDPPTAMLQPAMLRRLLAGGRVSPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTB8</accession>
    <name>A0A132PTB8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843844.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25292">
        <property type="protein sequence ID" value="KWX25292"/>
        <property type="gene ID" value="AFM11_03095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2489"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="134" mass="14923" checksum="89E56B6B62A33895" modified="2016-06-08" version="1">MTDTVTEVDILTERENARYEAALRADAAGFRELACPEMTYAHTDGSRDTLDVYLDKLTSGTLKYHTIEHPIAQVLVAGDAAVVVGDMRADLTVRGARKTIDTSAIAVWVKREQQWQLLAYQPTPKIARKDEHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTH8</accession>
    <name>A0A132PTH8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844793.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20075"/>
    <dbReference type="EnsemblBacteria" id="KWX25636">
        <property type="protein sequence ID" value="KWX25636"/>
        <property type="gene ID" value="AFM11_05265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2938"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="187" mass="20749" checksum="9C3E9D9F989FED45" modified="2016-06-08" version="1">MGTLNFTATVSLDGYVADADGDFDWSGPSDAVFAVHLERMAEVSTEVLGRKTYALMDYWETYPDDEDRPAAEREFAKRWQAIDKVVVSTTLTDDDLGSDRARLVPDLSLDGLQQIVDRASGLVEIFGPTTAAAAIRAGLVEDFQFFVVPKMVGGGLRALPDDVHLDLRLVEHRVFDDGIVHLRYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTI7</accession>
    <name>A0A132PTI7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844787.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25633">
        <property type="protein sequence ID" value="KWX25633"/>
        <property type="gene ID" value="AFM11_05250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2935"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="74" mass="8215" checksum="6C9107BE083FF039" modified="2016-06-08" version="1">MSLYDYEVSRQIGATDPPFYSLIMAAIRKADSQNAARLRNAFPEVHDEFTARYNAPGGMLPTDPEVARSSEFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTP6</accession>
    <name>A0A132PTP6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_04835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844645.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20310"/>
    <dbReference type="EnsemblBacteria" id="KWX25567">
        <property type="protein sequence ID" value="KWX25567"/>
        <property type="gene ID" value="AFM11_04835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2848"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="247" mass="26872" checksum="592B65FDEAA02EA7" modified="2016-06-08" version="1">MSAPIDAAKPYRSAAVVNRPAEDLPEAVAEGVAQFLGKPRARGWIHVYSAVIAFIAGAALVSVSWSVESTRAGLATLLYTFTIVAMFAVSGTYHRVNWTSASARKWMKRLDHSMIFIFIAGSYTPFALLALPESKGMVLFWIVWGGAIAGVLLKMFWPSAPRWLGVPLYILLGWVAAWFIGPIMHGAGVAAVVLLIVGGALYSIGGVLYALKWPNPWPTTFGHHEFFHACTAVAAICHYIAMWFAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTR5</accession>
    <name>A0A132PTR5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20720"/>
    <dbReference type="EnsemblBacteria" id="KWX25703">
        <property type="protein sequence ID" value="KWX25703"/>
        <property type="gene ID" value="AFM11_04425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2761"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="193" mass="20942" checksum="DAAC0E01A0E4B633" modified="2016-06-08" version="1">MPENVTAEQARQAALMTYIFNAGTGYGSSRGNANNDFAETPYSAAEVQRIKDRQEANSWSYDLLEHATGSFAATPNGMVMGVGGELIQQTVSAQAGTCVGDVFAVNMDHPPGGAAEELRKIIQTGTPAWQSDDGNVHRNVDLDLDRVLHHEERHSQQWAQKGFLKFVQEYFTPTGAEHNPFETNAGAGDGGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU05</accession>
    <name>A0A132PU05_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842300.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33665"/>
    <dbReference type="EnsemblBacteria" id="KWX25821">
        <property type="protein sequence ID" value="KWX25821"/>
        <property type="gene ID" value="AFM11_00550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.113"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="167" mass="18293" checksum="D3DDFB4772F0726E" modified="2016-06-08" version="1">MPSPPDKRDPIALARANWEAAGWGDVAGGMVAVTSVMRAHQILLARVETALRPYDLSFSRFELLRLLAFSRTGAMPITKASDRLQVHVTSVTHAIRRLEANGLVERIPHPTDGRTTLVRITDLGRSTVEDATVTLNEQVFADVGMSDEESRALAASIETLRRNSGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU07</accession>
    <name>A0A132PU07_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844176.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25677">
        <property type="protein sequence ID" value="KWX25677"/>
        <property type="gene ID" value="AFM11_03740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2624"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="253" mass="27464" checksum="202F2F42CC22B6C6" modified="2016-06-08" version="1">MPRTVLVTGATGTLGHHVVPEATEAGHHVKALSRRDRVGYTGVHWQRGDLLAADGLDGALDGVDVVVHCATQPTGSKDVTATRNLIEAARRAGVGHLIYISIVGIDDIPLPYYKTKLRVEQLLASSGVGYTVLRATQFHELIEMIFSIQRFSPVLWALRDVRFQPIDTRDVARRLVELIDTEPSGRVADIGGPEVRLHSELGHLYLSAHNSGRHVVSFTMPGRIVAGYRSGANLTPENSVGTTTFQDYLGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU42</accession>
    <name>A0A132PU42_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20285"/>
    <dbReference type="EnsemblBacteria" id="KWX25572">
        <property type="protein sequence ID" value="KWX25572"/>
        <property type="gene ID" value="AFM11_04860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2853"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="500" mass="55890" checksum="605871D472D97B24" modified="2016-06-08" version="1">MTVQATSAPIQIDTCDVCIVGAGIAGLNALFAASRYLSRDQKVILIDRRARVGGMWNDTYSYVRLHQPHPMFTAGNIKWTLGREPSYLATKDEVLDHFQHCLHEIKKRVTVDERYGWDLQSEVETGVNVRITCRTPDGGQRVIEAKRLIKAYGIRVMPNEPLELSSARVHSVSPDYCDVRSGPMRDSDAPVWLIGGGKTAMDTAHTLITAYPGREVNLVAGSGTFFASREKFFPVGARRWWGSTLLSSMAIDMCREFDGTNENELADWFRTRYGTWLTPQTGNFLLGVLSETENKAIAAGLNDVIMDHLDDVVDRDGSTEAVFRSGATETIREGSWIVNCTGYLTKGDHPYEPYVSAGGSVLSIQPRSATMHLTSYMGYFLTHAMFLDKLAELPLYEVDMQDLWDKHKSVLPYTLFALAQYNLGLMADAMPAKVFGECGLDYDRWYPWPRRTAGVVRFMRVHGREREHLRRSLDTVRDRFAVRCGPLSSGEATTSATAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU61</accession>
    <name>A0A132PU61_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_00885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842471.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33920"/>
    <dbReference type="EnsemblBacteria" id="KWX25881">
        <property type="protein sequence ID" value="KWX25881"/>
        <property type="gene ID" value="AFM11_00885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.183"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044049">
        <property type="entry name" value="EccD_transm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19053">
        <property type="entry name" value="EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="450" mass="44490" checksum="C40525CDA85E43E6" modified="2016-06-08" version="1">MMPDALRFVSIHCGFVVAGREGPVTIDLVLPAALTVNELMPSIVDAVGAPGGKPRSWQLSLIAGRTLDDSMTLVQNGVDDGDLLMLAAVAVEPPRLRALTAALAADGPGPETPQGLRSAGCLLACLLGMVAVVCAGLGTQGWSRVVAAAALAVIVTAAALAGQRIGFGRRTVATLSVAAVAQAAVLGFLVVPDGPDAANFFLAAVAAGCVGVALLRVSDCGTDVLLAVVTVAALIGLATAPAVVWPLSASAVGAVLSAVAMGALSLTPRLSIALAGLTPPIPGDETDGTETHGDTGISTDALAERGRRALVGLVTGCSAAAALGTLLVAVDSRHAVTPAALALAAAVGVALLLRSRSHASGRCRNMLTISGFCSLTAMFALVVVWSPGYGSWTGAAAVAVGLAVLSPAAVTSPAAIRVVDAVEYIALAAVAPLACWLTGIADAVRGLGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUF6</accession>
    <name>A0A132PUF6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842772.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34405"/>
    <dbReference type="EnsemblBacteria" id="KWX25966">
        <property type="protein sequence ID" value="KWX25966"/>
        <property type="gene ID" value="AFM11_01435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.294"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="245" mass="24771" checksum="5E78C26CD13BBB1C" modified="2016-06-08" version="1">MSLESKAALITGGSRGIGAAIARRLAADGADVAITYHSSPERAATVVDEITATGSKAIAVQANSAAPEAARQAVDAVIDAFGRLDILVNNAGVFPNGPLDQVSAAEVDQAIDLHIRAPFLFSQAAAAVMGEGGRIITIGSTLADHVPYPGVTLYSATKAAVAGLARGLARDLGPRGITANVVHPGNTDTEMNPADSDDAIADLPNIPLGRYGRADEIAAAVAYLAGPDAQYVNGTTLTVDGGYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUG3</accession>
    <name>A0A132PUG3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842846.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25988">
        <property type="protein sequence ID" value="KWX25988"/>
        <property type="gene ID" value="AFM11_01610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.332"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="53"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="188" mass="19656" checksum="05CC7751E103121F" modified="2016-06-08" version="1">MTRFPRLTPDTAQGAARDLLGGLVARHGEIGSMVATMAHSPAVLGGYLDLSRATKRSKLPRHITERISIAVQHRQGCALCLAAHISGARAAGVDDSEIEYAREGTSADPAIAAIVAFGLQVYTAPATITDGQIAGLRHHGYTDRQIIDVVGIVAVNVLTGAFNLVAGLQPTEVPGSHQTHTAVERPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUJ6</accession>
    <name>A0A132PUJ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842681.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34325"/>
    <dbReference type="EnsemblBacteria" id="KWX25944">
        <property type="protein sequence ID" value="KWX25944"/>
        <property type="gene ID" value="AFM11_01290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.264"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="244" mass="26303" checksum="4A6FF0F88F1F50E9" modified="2016-06-08" version="1">MLGLPEPITACLFDLDGVLTDTASVHKKAWKAMFDDYLRARSERSGEPFVAFDIGTDYLSYVDGKRREDGVRSFLASRHITLPEGGPDDDAGAETVHGLGNRKNEMFHKTLREEGVEVFDGSRRYLEAAAAAGLRRAVVSSSANTREVLEVTGLARFVELRVDGVTLRDEHIAGKPAPDSFLRAAELLDVSPAQAAVFEDALSGVAAGRAGNFGFVVGVDRVGQAQQLRQDGADIVVTDLAELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUL4</accession>
    <name>A0A132PUL4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_01760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842905.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34510"/>
    <dbReference type="EnsemblBacteria" id="KWX26005">
        <property type="protein sequence ID" value="KWX26005"/>
        <property type="gene ID" value="AFM11_01760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.362"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="154" mass="16776" checksum="B99E7CBCD8B2A21D" modified="2016-06-08" version="1">MFRLMFYSPRIAPNTGNAIRMVAATGCELHLVQPLGFDLSEPKLRRAGLDYHDLASVTVHDDLPAAWRVLMPARVYAFTAHAAASFADIAYEPGDVLMFGPEPTGLDDETLADPHITARVRIPMLAGRRSLNLSNAAAVAAYEAWRQHGFTGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUR4</accession>
    <name>A0A132PUR4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="13" type="ORF">AFM11_00275</name>
        <name evidence="14" type="ORF">AWC31_33385</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842161.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33385"/>
    <dbReference type="EnsemblBacteria" id="KWX25772">
        <property type="protein sequence ID" value="KWX25772"/>
        <property type="gene ID" value="AFM11_00275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11583">
        <property type="protein sequence ID" value="ORX11583"/>
        <property type="gene ID" value="AWC31_33385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.56"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX25772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX11583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="287" mass="31397" checksum="4DDA6AACB4C9D7B7" modified="2016-06-08" version="1">MGQKINPHGFRLGITTDWKSRWYADKQYKDYVKEDVAIRRLLATGLERAGIADVEIERTRDRVRVDIHTARPGIVIGRRGTEADRIRADLEKLTGKQVQLNILEVKNPESQAQLVAQGVAEQLSNRVAFRRAMRKAIQSAMRQPNVKGIRVQCSGRLGGAEMSRSEFYREGRVPLHTLRADIDYGLYEAKTTFGRIGVKVWIYKGDIVGGKRELAAVAPAADRPRRERPSGTRPRRSGSSGTTATSTEAGRAATEEAPAAPAIAEATGGTEAAAATAAETTTENSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PW44</accession>
    <name>A0A132PW44_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_01420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34390"/>
    <dbReference type="EnsemblBacteria" id="KWX26242">
        <property type="protein sequence ID" value="KWX26242"/>
        <property type="gene ID" value="AFM11_01420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.291"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="331" mass="35154" checksum="D7E2F64F3B82D840" modified="2016-06-08" version="1">MALVYLLASPEAEIVGIASTAGNVPVQQVCVNNLGLLKLCGATGIPVSKGAEQPLKAPLRTAEDTHGPQGLGYARLPASDLPLTDYDAAEAWVRAARAYPGELIGLATGPLTNLALAMRIEPGLPKLLRRLVIMGGAFDYRGNTTPVSEWNVSVDPESAAEVFGGWGAAWGLDDPGHVPIVLGLNLTENIAMTPALLNRLAAAGGATSAPMSVLDERGTRSTSVNPLICVFEDSMRFYFEFHFDTGDGYLAHLHDPLAAAVALDPDLVQYRQTTVDVELTGTLTRGMTVADWRGHWGRKPNALIGVDVDPVAFFDRFIDRVGAFAAALRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAY3</accession>
    <name>A0A132PAY3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859812.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02675"/>
    <dbReference type="EnsemblBacteria" id="KWX19491">
        <property type="protein sequence ID" value="KWX19491"/>
        <property type="gene ID" value="AFM11_35575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5851"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="269" mass="29632" checksum="5DF3D14BA4C09B28" modified="2016-06-08" version="1">MSHREALISVTDLRKVFAVRGEDGKRGEFVAVDSVSFDIQRGETFGLIGESGSGKTTTGRMVLGLEKPTSGSVTFDGNELVGLSDLDMRRYRRHIQIVFQDSGSAFNPRRSVGSQIAYPLNLFRTCSPSEARTKVLELLDRVGMLPSHYDRYTHEFSGGQRQRLGIARALITDPDFVVLDEPTAALDVSVQAQILNLLKDLQRERKLTMLLITHNLALVEHMCEHAGVLDHGKLVEVGPVDRLLTAPATDITRKLVDAVLEPELAGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAY9</accession>
    <name>A0A132PAY9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_35565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859806.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02685"/>
    <dbReference type="EnsemblBacteria" id="KWX19489">
        <property type="protein sequence ID" value="KWX19489"/>
        <property type="gene ID" value="AFM11_35565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5849"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="110"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="314" mass="33190" checksum="C412146FFBD5041C" modified="2016-06-08" version="1">MNALAAAAGRRAFPRVRRTSAGGHAPVESDTPKPQWRLAVRAFSRDRMAVVSLVVLVLVALASIFAPLLTPYSPTAGDPVDRLAGIGTEGHLLGLDGQGRDIWTRLLYGGRNSLMVAVVPILVVFPLALMIGLFAGFKRSKAGEVLMRVLDVLFAFPLVLLAIALSAVLGAGLGNVMLAIGITLIPYMARVAYTATVQEASKDYIEAARAYGANPLLLMSRELMPNVVVQLLVYATTLCGLMIVVASGLSFLGVGVIPPTPDWGIMTADGKNVLLEGIYHVATIPGLVILVVSLAFNLIGDGIRDALDPRKQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB12</accession>
    <name>A0A132PB12_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mercury transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000044">
        <property type="protein sequence ID" value="KWX19521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19521">
        <property type="protein sequence ID" value="KWX19521"/>
        <property type="gene ID" value="AFM11_35460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5825"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="2"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="28904" checksum="58464149486453D4" modified="2016-06-08" version="1">MLAPVNPCGFALLPAWITHTLGDTATEPLGVRTARALRTGVAFTLGFAGTLAVAGLAISAGARALISAAPWLGLVVGVALVLLGVVMFTGRVLGLRLPTRALRPATGPGGTTGIVLAGIGYAAASLSCTFGVLLAVIAQAQATAGWGALLAVFVAYTLGAATILLLVSLAAAAAGTALTHHLAALARHGTRITATVLILTGAYLAWYWLPAVTGDTTGTNGFAALSTTASTWLQNHTPLMATIAALTVLTAAVTVLAHRMIRRRVTDAAPVDCCTPTTVIEEGRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB72</accession>
    <name>A0A132PB72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_35290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859766.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19560">
        <property type="protein sequence ID" value="KWX19560"/>
        <property type="gene ID" value="AFM11_35290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5788"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="173" mass="18470" checksum="177895362A94831E" modified="2016-06-08" version="1">MQTKALTEAGAERIWTERMSGARDDRPELAALLDYARRGDVLMVWRLDRLGRSLPHLLTVASDLQARGIELRSLTEAIDTSTAGGRLIFHVFGAVAEFERAVAAERTAAGVAAARAAGRHPGRPSLTADTIAAVQALDEAGTPRAQIARTLGISRSSVYRCLVKALVDAAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBN8</accession>
    <name>A0A132PBN8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppnK</name>
        <name evidence="5" type="synonym">nadK</name>
        <name evidence="6" type="ORF">AFM11_34450</name>
        <name evidence="7" type="ORF">AWC31_11220</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000036">
        <property type="protein sequence ID" value="ORX08700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859260.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11220"/>
    <dbReference type="EnsemblBacteria" id="KWX19740">
        <property type="protein sequence ID" value="KWX19740"/>
        <property type="gene ID" value="AFM11_34450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08700">
        <property type="protein sequence ID" value="ORX08700"/>
        <property type="gene ID" value="AWC31_11220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5234"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="200"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX08700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="307" mass="33139" checksum="75CA545A5358A1D0" modified="2016-06-08" version="1">MTAERMILLVVHTGREEATEVARRVEKVLGDNDIALRVLSAEAVDRGPLHLAPDDMRALGVEIEVVDADERAAEGCELVLVLGGDGTFLRAAELARNVEIPVLGVNLGRIGFLAEAEAEAIDRVLEHVINRDYRIEERMTLDVVVRVGTEVVNQGWALNEASLEKGPRLGVLGVVVEVDGRPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFARPMVTSPEASIAIEIEARGNDALVFCDGRREMVVPAGGRLEVTRCGTPLKWVRIDSAPFTDRLVRKFRLPVTGWRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBU1</accession>
    <name>A0A132PBU1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34170</name>
        <name evidence="4" type="ORF">AWC31_02620</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859101.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02620"/>
    <dbReference type="EnsemblBacteria" id="KWX19803">
        <property type="protein sequence ID" value="KWX19803"/>
        <property type="gene ID" value="AFM11_34170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11051">
        <property type="protein sequence ID" value="ORX11051"/>
        <property type="gene ID" value="AWC31_02620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5171"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="432"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="533" mass="57582" checksum="D15DA664A5659C87" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC10</accession>
    <name>A0A132PC10_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858962.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07505"/>
    <dbReference type="EnsemblBacteria" id="KWX19856">
        <property type="protein sequence ID" value="KWX19856"/>
        <property type="gene ID" value="AFM11_33880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5114"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009936">
        <property type="entry name" value="DUF1468"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07331">
        <property type="entry name" value="TctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="165" mass="16921" checksum="B6BCDFE5C63E3399" modified="2016-06-08" version="1">MGVAVKVDKAQYLVCLVLVVVGGFLIFDALTLAEGFAKVDPVGPKLFPLVIGIVLIALAVVLAAAIPRGSVGEADAGEDVDPNSPGDWRTVGLLVGLFVLVIVLVEPLGWAITGTLLFAGAATILGNRHYVRNIAIGAVLSVASFYAFYSGLGIPLPAGILDGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC16</accession>
    <name>A0A132PC16_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_33355</name>
        <name evidence="8" type="ORF">AWC31_02360</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858653.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02360"/>
    <dbReference type="EnsemblBacteria" id="KWX19870">
        <property type="protein sequence ID" value="KWX19870"/>
        <property type="gene ID" value="AFM11_33355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13382">
        <property type="protein sequence ID" value="ORX13382"/>
        <property type="gene ID" value="AWC31_02360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5003"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX13382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="397" mass="41514" checksum="6C86D1B620B70F5C" modified="2016-06-08" version="1">MQYGAPVITADGVLALSDRGAGVPLRELALVGLTAAIITYFATGWVRALAIRLGAVAYPRERDVHVHPIPRMGGLAMYIGVAAAVLLASQLPALTRGFVYSTGMPAVVVAGGLIMAIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPIGGVGTIVLDQVSSILLTLALTVSIVNAMNFVDGLDGLAAGLGLITALAICVFSVGLLRDHGGDVLFYPPAVISVVLAGACLGFLPHNFHRAKIFMGDSGSMLIGLMLGAASTTAAGPISQNAYGARDVFALLSPFLLVVAVMLVPALDTLLAIVRRTRAGRSPLSPDKMHLHHRLLQIGHSHRRAVLLIYLWVGIIAFGAASTIFFDPRHTGAVMVAAILVAIVVTLIPLLRRDSEASEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC42</accession>
    <name>A0A132PC42_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858705.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19888">
        <property type="protein sequence ID" value="KWX19888"/>
        <property type="gene ID" value="AFM11_33455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5022"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="140" mass="15783" checksum="AA6253ECBFE0CF6F" modified="2016-06-08" version="1">MIPSVCHELLAGDSALNTLGITADRIKERQSVDIRPFDSGHFIVVSADEQLYVPSINRGPRTLTVWVHTPWDRSRNYREIDRILNRIDDIYSGVTHAVGSDDVRVTMIRKTGRSGNLRDEGWKTIARNATYGVLYDEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC58</accession>
    <name>A0A132PC58_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33550</name>
        <name evidence="3" type="ORF">AWC31_02200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858758.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02200"/>
    <dbReference type="EnsemblBacteria" id="KWX19906">
        <property type="protein sequence ID" value="KWX19906"/>
        <property type="gene ID" value="AFM11_33550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13353">
        <property type="protein sequence ID" value="ORX13353"/>
        <property type="gene ID" value="AWC31_02200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5043"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="294" mass="30912" checksum="CCFAA91E3AD66DA8" modified="2016-06-08" version="1">MTTITTPPPVAPPPQLTPGGRTAFRLFLIAAAALVVVATLAGLGVAAWGVSALRVVTDHQALPATMRTLVIDTAQVPVAIRITADRETREAKADLRLVNTTRSGEHRLAVSTTGGEARISISGNPSPMLEWARGGEIVISLPPEQARRLTVRTEQEIGAVFAQADVDQLIARTTDGAIILSGAARRIEAHTVNGEIVSRDPIAVTEEFSATTSDADITVDFRDAAPRTVNAISRDGTVVIGLPEPGPYLVRAQSGSSTRVRVPETTNPDNAVGEITARSDNGEVVVEEVGLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC98</accession>
    <name>A0A132PC98_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_33190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858549.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17035"/>
    <dbReference type="EnsemblBacteria" id="KWX19950">
        <property type="protein sequence ID" value="KWX19950"/>
        <property type="gene ID" value="AFM11_33190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4970"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023921">
        <property type="entry name" value="ADH_Zn_actinomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03989">
        <property type="entry name" value="Rxyl_3153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="13"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="370" mass="38863" checksum="4BC95832667A7713" modified="2016-06-08" version="1">MKMNAPVLWDVNGDWSIEEVELDPPRDGEVLVSFHATGLCHSDHHPRTGDLAGPLPLIGGHEGAGVVEEVGPGVRDLRPGDHVVASFLPACGRCRWCARGRQNLCDLGAFINTGTQLDGTYRRHIGDQDINVMLLLGTFAPYGVVSEASLVKIDDDLPLSRACLVGCGITTGWGSAVNTANVQPGDTVVVIGCGGVGSGAIQGARLAGAEKIVAVDIASGKRYKAFEFGATHFATSMAEAASIVGDMTKGSMADSAILAVGLVESHMVGEALDIVGKGGAVVLTALAPETNVTPTMSMAALTLYQKRLLGTLYGEANPRNDIPRLLSLYRAGKLLLDEAVSTEYQARDINAAYDDMLAGRIIRGVVIHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCD1</accession>
    <name>A0A132PCD1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858260.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32085"/>
    <dbReference type="EnsemblBacteria" id="KWX19976">
        <property type="protein sequence ID" value="KWX19976"/>
        <property type="gene ID" value="AFM11_32710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4870"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="297" mass="32518" checksum="1CB1CB47F47F3E08" modified="2016-06-08" version="1">MQSADNLRFFLEVARTGRLNEAARNLAVDHTTVGRRITALEKAFGVRLFDRSPGGWHLTEAGADLLPRAESVESAVIAAYDARTTAAGPLTGTVRMVAPDGFGAFVVAPRLVELRRAHPHLDVELVTATEHGSLSARQFDIAVTLEEPLPRAVQVHRLAGYDLCLYAAPEYLASAPRISQLADLTDHTLIWYIDALLDVAPLRILDSLPHKQRVAVQTNNITGHWTAARSGLGIAPLPQYIGEPDTSLKIVLPESFSVRRTYWLVIPRELQQVGRVRAVAQFLRSTVATNPYLTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCE2</accession>
    <name>A0A132PCE2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858444.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32325"/>
    <dbReference type="EnsemblBacteria" id="KWX20005">
        <property type="protein sequence ID" value="KWX20005"/>
        <property type="gene ID" value="AFM11_32880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4905"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013454">
        <property type="entry name" value="Bifunc_RhaD/ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02632">
        <property type="entry name" value="RhaD_aldol-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="2">
        <location>
            <begin position="8"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="678" mass="72047" checksum="E640CC7FA4B86451" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCJ1</accession>
    <name>A0A132PCJ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858001.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20048">
        <property type="protein sequence ID" value="KWX20048"/>
        <property type="gene ID" value="AFM11_32260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4781"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="27466" checksum="B6990CFD425D8B32" modified="2016-06-08" version="1">MTGDTYVKDGVVYKETGPWTPSIRALLTHLETAGFGGAPRIAGQGYTYLAGSSPHPHAWPDDVVGEVGSLLRDLHDATSDFIPGACAVWKRSWLRDLGGHDIVYGHGDTAPWNIVGPPLAFIDWEFAGPVDRLWELAHTVWLNAHLVDDDVADLQDLPDATTRARHARAIVDGYGLPQDQRRDLVDRLVDVAAHSARHEVAEHAVTPSTDEAVAADGYPVLWAIAWRARSASWIARHRPQLRRAICDQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCZ0</accession>
    <name>A0A132PCZ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32080</name>
        <name evidence="2" type="ORF">AWC31_31770</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857967.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31770"/>
    <dbReference type="EnsemblBacteria" id="KWX20211">
        <property type="protein sequence ID" value="KWX20211"/>
        <property type="gene ID" value="AFM11_32080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12709">
        <property type="protein sequence ID" value="ORX12709"/>
        <property type="gene ID" value="AWC31_31770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4742"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX12709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="135" mass="15156" checksum="3BB3532EEDF26F1D" modified="2016-06-08" version="1">MSEAEREDYLAALHVGVIAVERPDRAPLAVPIWYGYQPGGDVLLWTEAGSVKEKLIRAAGRFSITVQDEQPPYRYVTAEGDVTAIEPAKDAEVRAIAVRYFGEDEGNKFTDENFTETSVIIRMKPSRWLSTDYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD07</accession>
    <name>A0A132PD07_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_32025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31870"/>
    <dbReference type="EnsemblBacteria" id="KWX20210">
        <property type="protein sequence ID" value="KWX20210"/>
        <property type="gene ID" value="AFM11_32025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4731"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="173"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="277" mass="30226" checksum="658512B76079CE22" modified="2016-06-08" version="1">MGSGIATVMARAGHRTILYDIDETNLKRGIDTVHGFFDKSVRIGKLDEAAGRAAKETLSGSTDLNDLAPCDVVVEAVFEDLALKKETFGRLDDIVSASTLFHTNTSTLPVTGIASGSRLPERVVGTHYCNPAPLMKLVEVADGRHTADWAHKATVEFLASLGKTSVVTKDRPGFIVNRFLIPWENSCIHALEAGWGTKESIDAAVLGALGHPMGPFRLLDIVGMDIHQQVATRLYEQLRDPRFFPPPMVERMVAAGDLGRKTGRGFYEYDDTRLFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDV6</accession>
    <name>A0A132PDV6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20518">
        <property type="protein sequence ID" value="KWX20518"/>
        <property type="gene ID" value="AFM11_30050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3903"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="72" mass="7539" checksum="B49B07522D12376F" modified="2016-06-08" version="1">MLAAVGSAIRHYRLQAGLTQAELAERAGIGRPHLNHIEGGRKNPTVVVLVHLARGLGVAPGELLASVSPDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDX0</accession>
    <name>A0A132PDX0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_30600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857054.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00585"/>
    <dbReference type="EnsemblBacteria" id="KWX20536">
        <property type="protein sequence ID" value="KWX20536"/>
        <property type="gene ID" value="AFM11_30600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4021"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="235"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="349" mass="36220" checksum="98BD677F87A1F00C" modified="2016-06-08" version="1">MSSFGVSAGVNADPAADALAALNELSRRAEQTTEAMHAAQLDLDAKLAAQRDAESLKIRDETALTVAHEQLQRHQSAVDKIAAATYMGGNPDGWTAVLTAESPQQLIDELATKRAMSTQMTDQIRAFRIAHERAQAAARSSESSAAAARSAAEQAAAVRAELQVKQSQLQREISAVQAQYEELTPDQRATLADPGPPPPPGAVPLAVAPDPAVVALPAPPVPGDGPPSGNTPEPSGQGALVVQAALTRVGAPYSWGAAGPDAFDCSGLIMWAFQQTGKSLPHSSQALAAGGQPVAVSDLQPGDIVTFYDDVSHAGIYIGDGMMVHASTFGTPVRVAPISSAPIHNARRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE34</accession>
    <name>A0A132PE34_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856547.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25115"/>
    <dbReference type="EnsemblBacteria" id="KWX20590">
        <property type="protein sequence ID" value="KWX20590"/>
        <property type="gene ID" value="AFM11_29775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3847"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="25955" checksum="F042C01C25C5C788" modified="2016-06-08" version="1">MSALTGRTALVTGASRGIGRAIALRLARDGARVGVHYGASADAAKQTVQDIIDSGGDAFAVQAKLGVPGDAAALWTAFDAHADGVDILVNNAGILGGRGAFTDVAEPAYDEIFAVNTKAPFFVTQHGLARLRDNGRIVNLSTRFTHGSRIPELMTYAMTKAAIDSFTATLAKQLAARNITVNAVGPGSTDTDMNAARLATPEGRATVAAQSPFNRVARPDDIADIVAFLASDDARWVTGQWIDASGGSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEF5</accession>
    <name>A0A132PEF5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_29285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040646.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20710">
        <property type="protein sequence ID" value="KWX20710"/>
        <property type="gene ID" value="AFM11_29285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3743"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="384" mass="41041" checksum="7D69CCFBB9E2EA2C" modified="2016-06-08" version="1">MELCESDERRDLRAAVAAIARSYGHEYYLSKSLAGEKSTELWREIGKQGFLGVNIAEEYGGGGGGIYELHAVGEELAAAGCPLLMTVVSPAICGTIIQAFGSEEQKQRWLPGIASGDMIMAFAITEPDAGSNSHNIATTATRDGDEWVLRGTKYYISGVDEAQAVLVVTRTGTDERGRGQLSLVVVPTDAAGLQKTLIPVQAVTPEKQFTLFFDDVRVPAENLVGEQDEGLRQVFMGLNPERIMGAALSTGIGRYALDKACAYARERQVWNTPIGAHQGVAHPLAHAKIQVELARLMTQRAAELHDAGNSGAGEAANMAKYAAAEAGILALDQAIQTHGGNGMATEYGLATLWGPARLMRTAPISREMILNFVAQHSLGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEQ7</accession>
    <name>A0A132PEQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856863.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20472">
        <property type="protein sequence ID" value="KWX20472"/>
        <property type="gene ID" value="AFM11_30325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3963"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453191" evidence="1">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="LMWPc" evidence="2">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="138" mass="14707" checksum="F7F51425CBAC4A33" modified="2016-06-08" version="1">MADTSVLFVCVSNAGKSVMAAGLMRHLSAPNIHIASAGTHAKTAVNTLSAQVLAEVGVDISGHQPTQLTDQMIDDADLVIIVGSQAHLADHPGTRIQRWDTDEPSLRGIDGIQRMRIIRDDINTRVQALADELSSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEX5</accession>
    <name>A0A132PEX5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855673.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10235"/>
    <dbReference type="EnsemblBacteria" id="KWX20885">
        <property type="protein sequence ID" value="KWX20885"/>
        <property type="gene ID" value="AFM11_27700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3414"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="6"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="415" mass="45515" checksum="A8ACDD47391EBE32" modified="2016-06-08" version="1">MSAVGQPLTLACGQTLANRLMKAGLSEQLSDREHAPTRELEQLYDRWGRGGCGLMITGNVTVDRRHMAEPRNVAIDDDCDRDRLRRWARAAQRGGRLIWMQLNHPGRQANPLAGRTRPVAPSAVPLSVPGAPRPRSLTATEIEATVQRFATAATIAKEAGFDGVQLHGAHGYLISQFLSPLANVRDDDWGGDPDRRMRFPVEVLRAVRRAVGDEFAVGIKLNSADFQRGGFTEQESQQVVARLACERIDLIEISGGTFEQPAMMGSITRQSTREREAYFLSYAERVRRHAGTVPLAVTGGFRSRGAMEQALTEGACDVIGIGRPLCIDPDAAHQLLSNADHYAPAGTPRVTGRALLGRMIDLHAADALLDVQWHTDQIHRIAAGREPDPKRPWWFSIATTARRNGLAAIPRPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF24</accession>
    <name>A0A132PF24_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855811.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10545"/>
    <dbReference type="EnsemblBacteria" id="KWX20930">
        <property type="protein sequence ID" value="KWX20930"/>
        <property type="gene ID" value="AFM11_28025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3479"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="387" mass="39935" checksum="6A2AD0B164B6C0FE" modified="2016-06-08" version="1">MDAPQPDRTLHHLADVVPSVLAAMGAAGFEARIDLPTPVRGACVLLIDGLGAELLDAHAVDAPVLAGLRGQTLQVGFPSTTAAGLAAIGTGCRSGEHGLVGYSFRVPDAGVINALRWRPHPWGDDLRDTVRPEAVQPLPTTFERAVDAGFAVSVVSGAEFARSGLTRAVLRGGDYIGVHATGELAAAVSGCIAAGGFCYGYHADLDLVGHLHGPGSTAWRMQLRQVDRLVESVVETLPADGLLAVVADHGMVAVDPTEVVDLDTTPALQTGVAAVGGEARARHVYTATGAADDVLAAWRETLADTAWVLSRDEAIAAGWFGGRVREDVLPRIGDVVAAARGSAALMRRTAEPLESALVGHHGSLTSAEQRIPLLIATGLPGSLPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF83</accession>
    <name>A0A132PF83_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uncharacterized N-acetyltransferase AFM11_28100</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_28100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10645"/>
    <dbReference type="EnsemblBacteria" id="KWX20998">
        <property type="protein sequence ID" value="KWX20998"/>
        <property type="gene ID" value="AFM11_28100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3495"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044161">
        <property type="term" value="C:host cell cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1036">Host cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="5">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="5">
        <location>
            <begin position="89"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="5">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="5">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="396" mass="43044" checksum="A7E41185B0660802" modified="2016-06-08" version="1">MTPQILHDITDADWAGMALLGSTAFGELEDPETMAVWRTLVPGGGAVVVRDADIVGQSLYLDLTLTVPGGAELPVAGLSFVAVAPTHRRRGLLRAMYTQLHDRIADAGYPIAALTASEGGIYGRFGYGPATIEQEVSIDRRFAEFHATAPDPGGVRMVKPADHRDELIDIYDRWRRQTPGGLVRPAGLWDDLLADREKARGGGTEWFAFLHRDGYALYRLHGDGPKVVRVGEFTAATPEAHAALWRALLGLDLMEKVTTWTHPGDALPYLLTNPRLARVTSSADDLWLRIMDIPAALQARQYSSDLDTVLEVADGFRSDGGRFALQIRDGRAQCTPTDEPADVELDLDVLGSLYLGGHRADGFASANRLRTKDSELVQRISAAFVSAVPAELGFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFK1</accession>
    <name>A0A132PFK1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855309.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06985"/>
    <dbReference type="EnsemblBacteria" id="KWX21054">
        <property type="protein sequence ID" value="KWX21054"/>
        <property type="gene ID" value="AFM11_27135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3302"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453290" evidence="1">
        <location>
            <begin position="31"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="99"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="510" mass="54168" checksum="76A77790D163A665" modified="2016-06-08" version="1">MAACGAMKVRIRFGALLAVMVLAVAGCSQVIEGRAIIAVPRPGTPVQWLPCNAGAGDQAPIPDAAECGLLSVPVDYSKPDGDVARIAMIRFPATGEKIGSLVINPGGPGESGVESALSLLPSLPQSVKERFDIVGFDPRGVASSNPAVWCNSDADNDRQRADPTVEYTPEGVAHLEAETKAFVQRCVDKMGEEFLANVGTDNVAKDLDAIRAALGDEKLTYLGYSYGTRIGATYAEEFPDKVRAMILDGAVDPNADPVEESVRQAAAFQKAFDDYAADCAKSPDCPLGTDPAKAVEVYKSIIDPLVQNPARTRDGRGLSYSDATVGTILPLYSPNLWRHLTDALKSLKEGDGNLMLALADLYMGRDAKGHYNNSTDARVAVNCMDKPAITDRAIVVEQDRRLREVAPFMSYGEFTGNAPLGACAFWPVPPTSTPHEIAVSGLPPVLVVSTTNDPATPYQAGVDLARQLGGTLVTFDGTQHTVVFQGDKCIDDIAATYLVDVTVPPPDTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFX8</accession>
    <name>A0A132PFX8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855024.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22700"/>
    <dbReference type="EnsemblBacteria" id="KWX21230">
        <property type="protein sequence ID" value="KWX21230"/>
        <property type="gene ID" value="AFM11_26635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3198"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2470" evidence="1">
        <location>
            <begin position="173"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="260" mass="27846" checksum="339E4092B8068F5C" modified="2016-06-08" version="1">MAVAAPTTAERIRSACARGGGAMLAVEGIEPVESPVHHLLDDGSFAITVPEAGPLVGMVLSSGSAGVQAVLEMTDYAPLPLREPVRSLVWIRGRLQHVPSGEIPALLDLVATEDPNPALLQVNSGSGPVEDTYALMRLEIESVVVADATGAESVSLGALLQARPDPFCAMESCWLQHMESAHRDVVERLATRLPMTLRQGRVRPLGLDRYGVQLRVENENGDHDVRLPFAKPVDDVTGLSQAIRVLMGCPFLNGLRARKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG03</accession>
    <name>A0A132PG03_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_26485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854949.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22850"/>
    <dbReference type="EnsemblBacteria" id="KWX21204">
        <property type="protein sequence ID" value="KWX21204"/>
        <property type="gene ID" value="AFM11_26485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3167"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="434"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="548" mass="56118" checksum="F6995BF1A181E587" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGB0</accession>
    <name>A0A132PGB0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854687.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35770"/>
    <dbReference type="EnsemblBacteria" id="KWX21388">
        <property type="protein sequence ID" value="KWX21388"/>
        <property type="gene ID" value="AFM11_26125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3090"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="179" mass="19210" checksum="F0D666F3234755AF" modified="2016-06-08" version="1">MSLHTSAVDVLTHWRTTDPAQDSLRHAVLSFLAARPDACLRECAPGHITASSLVLDHTGTQTLLTLHPRFGRWLQLGGHCEAGDADVHAAALREAAEESGISGLTIDPELAALHVHPVKCSLGVPTRHLDLQFLVRAPEGAEIARSDESLDLQWWPLDALPADTDFGLAQLARAAADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGD8</accession>
    <name>A0A132PGD8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDP-mannose pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854690.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35765"/>
    <dbReference type="EnsemblBacteria" id="KWX21418">
        <property type="protein sequence ID" value="KWX21418"/>
        <property type="gene ID" value="AFM11_26130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3091"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="353" mass="36898" checksum="047DFF6351A554E3" modified="2016-06-08" version="1">MDAVVLVGGQGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIKHVVMGTSYKAEVFEDAFGDGSELGLEIEYVTETEPLGTGGAIANVADKLRYDTAMVFNGDVLSGADLGALLEAHDEHRADVTLHLVRVGDPRAFGCVPTDPDGLVTAFLEKTQDPPTDQINAGCYVFKRAVIDKLPRGRALSVEREVFPGLLADGLRVCGYVDMSYWRDMGTPEDFVRGSADLVRGIATSPALNGHRGESLVHEGAAVAPGALLIGGTVIGRGAEIGAGARLDGAVIFDGVRVEAGAVIERSIIGFGARIGPRALIRDGVIGDGADIGARCELLRGARVWPGVAIPDGGIRYSTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGQ7</accession>
    <name>A0A132PGQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854246.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27610"/>
    <dbReference type="EnsemblBacteria" id="KWX21525">
        <property type="protein sequence ID" value="KWX21525"/>
        <property type="gene ID" value="AFM11_25290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2420"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="461" mass="49197" checksum="75F9483A21913799" modified="2016-06-08" version="1">MTVTQESAVLPNGLSIEEAKAEAARAYELDRAHVFHSWSAQEELSPMTITAAQGSYVWDGHGNRLLDFSCQLVNTNIGHQHPKVVGAIAEQAAKLCTVAPQYANAARSEAARLIAERTPGELNKVFFTNGGADAVEHAVRMARLHTGRYKVLSRYRAYHGGTETAINLTGDPRRWPNDHGNAGVVHFFGPFLYRSQFHATTEAEETERALAYLDQLIRLEGPSTIAAIILESIPGTAGIMVPPPGYMAGVREICDRYGIVFIADEVMAGFGRSGKWFSIDHFDVVPDLLTFAKGVNSGYVPLGGVAISPAIYETFAHRAYPGGLTYSGHPLATAAAVATINAMEEEGMVDNAAKIGAEVIGPGLAELAAKHRSVGEVRGAGVFWAVELVADQETREPLAPYGGSSPAMNAVIAACKAGGLLPFANFNRIHVVPPCNVSADEVREGLAILDKALDVADEHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGT1</accession>
    <name>A0A132PGT1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Substrate-binding protein, ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854259.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27645"/>
    <dbReference type="EnsemblBacteria" id="KWX21531">
        <property type="protein sequence ID" value="KWX21531"/>
        <property type="gene ID" value="AFM11_25325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2427"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453328" evidence="1">
        <location>
            <begin position="26"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="54"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="327" mass="34246" checksum="69CA6E215CBEB8FD" modified="2016-06-08" version="1">MSWFPKAFAAACTAVALIAGATACADESAGPDTEGTDALSISATGVDSLPFMAILQVGIDKGWFSEQGLNVDLYSGGGGGNTLRVVTSGDADMAIAGNSSVILAAQQANSNLKVVAPWFQINDFSWISPPGRKLENATLGFSSAGSSTELIVKGLERKLGVKSQAVGPMGDNWTAAKAGQITAGWAMQPFIADKQASERAEVLVDSRDVVGDLPADLVAVNTEYAEQNPDNIRNFFVVANRLNEWLVANPDEAAAEIAPLVGVTPEVMKSAFANNPDLAKGYSLKVDTAGLTNLSELMVGAGQISEPIDWATMLDQQYLPDDARADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH06</accession>
    <name>A0A132PH06_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_23945</name>
        <name evidence="5" type="ORF">AWC31_24210</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853506.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24210"/>
    <dbReference type="EnsemblBacteria" id="KWX21593">
        <property type="protein sequence ID" value="KWX21593"/>
        <property type="gene ID" value="AFM11_23945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15654">
        <property type="protein sequence ID" value="ORX15654"/>
        <property type="gene ID" value="AWC31_24210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2147"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX15654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="194" mass="20922" checksum="1A71B27A9E20062E" modified="2016-06-08" version="1">MDYAHSDAGATVSSTKIVIAGGFGVGKTTFVGAVSEIVPLRTEALVTNVSHGHDDIDATPGKETTTVAMDFGRITIASDLVLYLFGTPGQRRFWFMWDDLVHGAIGAIVLVDTRRLDDSFAAVDFFEARSLPFLIAVNEFDDAPKHTVEDLREALSVSPNVPIISVDARQRDSAKNALIAITSYALDRLPTTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH44</accession>
    <name>A0A132PH44_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_25300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854251.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27620"/>
    <dbReference type="EnsemblBacteria" id="KWX21527">
        <property type="protein sequence ID" value="KWX21527"/>
        <property type="gene ID" value="AFM11_25300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2422"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="27335" checksum="56EB789205205B13" modified="2016-06-08" version="1">MPPRTANRRTAPQSASGNGKSDFVRPKTAQQAVAEALRRDITSGKLAPGSWIVQESLAEHFGMSRIPIREALKTLEAEEYITYVPHSGYRVAKLGLEELLEVFRLRDILEAELIRDAMPDVTDEVIERMRDQMAEMDRAAAAGDLIGVGLANREFHFLTFEASRMARTKRIVNQLWNTADAYRPLYAHLMDLDKVNSEHVLLVEAMAARDVERVVALNHEHRMHAIDHLHIVFGREDAEADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHA1</accession>
    <name>A0A132PHA1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853863.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21706">
        <property type="protein sequence ID" value="KWX21706"/>
        <property type="gene ID" value="AFM11_24675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2296"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="303" mass="31565" checksum="1B354A4F6BF06891" modified="2016-06-08" version="1">MLGNGLAVLFALCAAVFAAIGIVVRQRATMDVPPEKGVSTAMLRTLLRRKLWWAGTASAIAGYAFQALALAFGSLLLVQPVLVSALLFALPLSAHLANRRVTRAEWLWALLLTTALTVFVVLARSSTGSYAVPVSTTVTVAVVCAIVVTLFVLLATRSTNWRRAVLLAAGVGVMLGVVAVLTKIVMHMVAEGSMLATLATPALYLVVLLGVVATLLQQSAFHAGSLQTSVPTMLVLEPVVAVMLGSIVLGEHLSITGWEPVALSLAIGAMAAATIALGRDEGAYEEKLEAELEAEMKAKAGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHD8</accession>
    <name>A0A132PHD8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate starvation-inducible protein PhoH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_23205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853073.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27970"/>
    <dbReference type="EnsemblBacteria" id="KWX21768">
        <property type="protein sequence ID" value="KWX21768"/>
        <property type="gene ID" value="AFM11_23205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1994"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005769">
        <property type="entry name" value="PhnE/PtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01097">
        <property type="entry name" value="PhnE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="341"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="532" mass="56177" checksum="CFDDB32CCCB68767" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHE7</accession>
    <name>A0A132PHE7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphonate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_23210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853076.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27975"/>
    <dbReference type="EnsemblBacteria" id="KWX21769">
        <property type="protein sequence ID" value="KWX21769"/>
        <property type="gene ID" value="AFM11_23210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1995"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012693">
        <property type="entry name" value="ABC_transpr_PhnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02315">
        <property type="entry name" value="ABC_phnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="17"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="270" mass="29194" checksum="B5596A067C10E737" modified="2016-06-08" version="1">MSTVGPDHPVAGDDLVVVARNVTKKFGDTLALDDVSLDVRRSELLVLLGLSGSGKSTLLRCLNGLHPVTSGAVDVGGTRVDQASSAQLRALRRRVGFVFQHFNLVGRLSCLENVLIGGLGQLRFPRYGALTYPKSMRVAALAHLDRVGLADFAERRADTLSGGQQQRVAIARTLMQRPALLLADEPVASLDPENAGVVMDLLFRVCIEEKLTVVCTLHQVDLALGWAHRLVGLRNGQKVLDRPAVGMTRDDVMAIYQRVDPTVTSTTRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHS3</accession>
    <name>A0A132PHS3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine, histidine-dependent amidohydrolase/peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29940"/>
    <dbReference type="EnsemblBacteria" id="KWX21853">
        <property type="protein sequence ID" value="KWX21853"/>
        <property type="gene ID" value="AFM11_23705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2098"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453046" evidence="1">
        <location>
            <begin position="25"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="79"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="190" mass="20396" checksum="3DFAB35E33467694" modified="2016-06-08" version="1">MTKGASRLALALSAVFVVVAVGMAAVLFRDARVSVVSVKPDFPALDRTALSPVQQRVVDILRTQYDAQPAGTAFSEGVDEPWCADFVSWVLNEAGQPLSNPHSGHWRIPGVYTLQEYYQAAGRFEAPGGYRPQTGDVALYADGSPLGLHTNFVLVVDDNGITTVGGNEEGDIKVRTFEPGSWLLGYGRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHW7</accession>
    <name>A0A132PHW7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_22320</name>
        <name evidence="11" type="ORF">AWC31_08890</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852685.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08890"/>
    <dbReference type="EnsemblBacteria" id="KWX21911">
        <property type="protein sequence ID" value="KWX21911"/>
        <property type="gene ID" value="AFM11_22320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10260">
        <property type="protein sequence ID" value="ORX10260"/>
        <property type="gene ID" value="AWC31_08890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1814"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="148"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX10260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="307" mass="33213" checksum="F81A70BBD94D24F4" modified="2016-06-08" version="1">MIRHFLRDDDLSPDEQADVLALAAELKKAPFSRRPLEGPRGVAVIFEKNSTRTRFSFEMGIAQLGGHAVVVDGRSTQLGREETLEDTGAVLSRYVDAIVWRTFAQERLTAMASGSTVPIVNALSDEFHPCQVLADLQTLAERKGKLAGLRMTYFGDGANNMAHSLMLGGVTAGIHVTIAAPAGFEPDPQFVDAAQRRAAETGASVTLTADPNAAADGADVLVTDTWTSMGQENDGLDRVRPFRPFQVNAELLKLADPAAVVLHCLPAHRGHEITDDVIDGPQSAVFDEAENRLHAQKALLVWLLENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI62</accession>
    <name>A0A132PI62_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RecA/RadA recombinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Recombinase RecA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22455</name>
        <name evidence="3" type="ORF">AWC31_08755</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852949.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08755"/>
    <dbReference type="EnsemblBacteria" id="KWX22039">
        <property type="protein sequence ID" value="KWX22039"/>
        <property type="gene ID" value="AFM11_22455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10370">
        <property type="protein sequence ID" value="ORX10370"/>
        <property type="gene ID" value="AWC31_08755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1841"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="111" mass="11649" checksum="A844041DDFBF9AD8" modified="2016-06-08" version="1">MTDANNIRDLADVPAVEVITRAAVMLMSAAAEKIGLSAEDPDDSPHRDLDEARRLITALAGLVTASAEYLGPHAGPVRDGLKSLQLAFREASAAPDEPGKGPGEKYTGPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIB7</accession>
    <name>A0A132PIB7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852373.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04395"/>
    <dbReference type="EnsemblBacteria" id="KWX22099">
        <property type="protein sequence ID" value="KWX22099"/>
        <property type="gene ID" value="AFM11_21590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1666"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="9"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="281" mass="29743" checksum="F469614A8CACCE9B" modified="2016-06-08" version="1">MNTTILVTGSTGNVGRPLVSELVNAGARVRAVTRNPQAAAFPPEVELVESVAQGIPGATAVFLNSRGLGHELAATIDLARTSGVRRLVALSAINADEDDSRQPSRVRGDRNRETEQLAVASGLEWVSLRPTYFASNFAGMWSAQIRFGDVVSGPYADASLAPIADADISAVAAAALLTDKLVGQRIPLTGPEALTNTQLVAAIGSALGRPLHYQEVPADLVREHFVAIGFPVEFADGYLALMSDAVKTPALVTHEVDKILGRRATTFAEWASGHLHLFTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIG1</accession>
    <name>A0A132PIG1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">AFM11_21600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852377.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04405"/>
    <dbReference type="EnsemblBacteria" id="KWX22101">
        <property type="protein sequence ID" value="KWX22101"/>
        <property type="gene ID" value="AFM11_21600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1668"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="255"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX22101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="390" mass="40577" checksum="34C6B89BC6B5FA6B" modified="2016-06-08" version="1">MSDRRRVLVLGSTGSIGTQALEVIAANPDRFEVVGLAAGGGNPELLSAQRAETGVGNIAVADPAAAERIGDVTYAGPDAVTRLVEDTEADVVLNALVGALGLQPTLAALASGARLALANKESLVAGGPLVLKAAAPGQIVPVDSEHSAMAQCLRGGSADEVAKIVLTASGGPFLGWSAGDLRSVTPEQAGKHPTWSMGPMNTLNSATLVNKGLELIETHLLFGIDYDHIEVVVHPQSIVHSMATFTDGSTLAQASPPDMKLPIALALGWPDRVPGAALACDFTTASTWEFLPLDNEVFPAVDLARHAGKRGGCLTAVYNAANEEAAEAFLQGRITFPTIVETVGDVLHAADQWSAEPATVDDVLDAQRWARDQARRAVEQKSVRKGLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIG5</accession>
    <name>A0A132PIG5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23355</name>
        <name evidence="4" type="ORF">AWC31_28080</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853146.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28080"/>
    <dbReference type="EnsemblBacteria" id="KWX21792">
        <property type="protein sequence ID" value="KWX21792"/>
        <property type="gene ID" value="AFM11_23355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14992">
        <property type="protein sequence ID" value="ORX14992"/>
        <property type="gene ID" value="AWC31_28080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2026"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="142"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX14992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="250" mass="27704" checksum="9607349A70CDEA9A" modified="2016-06-08" version="1">MDFRAALLDQTRAFGELIASGDPATPVPTCPDWTLKQLFRHVGRGNRWAAQIIADRRSTELDPRDVRDGKPPDDLDGAIEWLNSGAALVAKAVDQVGSDARVWTFLGPRPAGWWIRRRLHEATVHRADAAMALGVDYDLDPELAADAISEWLERVCIEAKKYHRVPLESGQSVHLHATDDVLGPTGEWTVVNDEDGVWWSHDHGKGSAAVRGSAKDLLMVTTRRRTAADLGLEVFGDTAVWDAWLERTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIQ9</accession>
    <name>A0A132PIQ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sirohydrochlorin ferrochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852006.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06005"/>
    <dbReference type="EnsemblBacteria" id="KWX22240">
        <property type="protein sequence ID" value="KWX22240"/>
        <property type="gene ID" value="AFM11_20590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1455"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="237" mass="24544" checksum="4EC2DE5335CE9CC1" modified="2016-06-08" version="1">MTLVLTAHGSADPRSSANAHAIAGHLRRLLPDTDVRVAFCEQNAPNLADVLPDVAPGSVVTPLLLASAFHARTDIPGLIAQSGADVLQADVLGEDPRLLQVVRERLAGLGVSRFDAALGVVLTGVGSSHPAANARTASLAGSLAEGTRWAGVQVAFATGQTPSVPEAVEQLRASGAEHFVIAPWFLAHGRITDRVAEYARSQGIPMAEPLGPHRLVAATVLDRYEEALAAHSAGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIU3</accession>
    <name>A0A132PIU3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852389.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04445"/>
    <dbReference type="EnsemblBacteria" id="KWX22107">
        <property type="protein sequence ID" value="KWX22107"/>
        <property type="gene ID" value="AFM11_21640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1676"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="20944" checksum="FFC9E42A8336F1C0" modified="2016-06-08" version="1">MTGTNEQSVEMRVSDADRNGTLRRLHNAVALGLIDIAEFEERSALVSQARLHADLDALVGDLPGPGAIVTTAADRVELRGVLGSLKRHGEWTVPTRLALVRRMGSVELDLTRARFAGPMVVVEIDMKFGSLEIRLPDGASASIDDVEVIVGSATDRRRDAPADGTPHVILTGRVVCGSVDIRGPRKGWFGRGTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ03</accession>
    <name>A0A132PJ03_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Salicylate synthase MbtI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852014.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06025"/>
    <dbReference type="EnsemblBacteria" id="KWX22244">
        <property type="protein sequence ID" value="KWX22244"/>
        <property type="gene ID" value="AFM11_20610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1459"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019996">
        <property type="entry name" value="Salicylate_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03494">
        <property type="entry name" value="salicyl_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="184"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="450" mass="48645" checksum="2FD6E8F9CE213276" modified="2016-06-08" version="1">MTKVSFETSSDNAESIELSLPTGTNPVDLVAELARVLPERDGEDYVVYERDGEWTLALGVRAVVELDSDELRVIQDGVVQRQAWSGRPGAALGEAVDRLLLETDRLFGWVAFEFGTYRFGLQARLHPGTPLARILWPRTQFVVSDGRITLIGADDRQTEALRAVLADGVSAVPAATAVDVRADSSNYRDRVATAIDEITSGQYQKVILSRRFDVPFAVDFPATYRVGRHNNTPARSFLLHLSGIRALGYSPELVAAVRADGTVLTEPLAGTRALGRGADNDRAARDDLESNPKEIVEHAISVRTSVSEIAEVAEPGTAVVLDFMTVRERGSVQHLGSTVGGRLQRSMDRMDALETLFPAVTASGIPKAESVDAILRLDEAPRGLYSGAVVTFSADGGMDAALTLRACYEAEGKTWLRAGAGIIGDSTPDREFEETCEKLTTLAPHLVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ34</accession>
    <name>A0A132PJ34_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recO</name>
        <name evidence="10" type="ORF">AFM11_20735</name>
        <name evidence="11" type="ORF">AWC31_06150</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RecO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852252.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06150"/>
    <dbReference type="EnsemblBacteria" id="KWX22360">
        <property type="protein sequence ID" value="KWX22360"/>
        <property type="gene ID" value="AFM11_20735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10304">
        <property type="protein sequence ID" value="ORX10304"/>
        <property type="gene ID" value="AWC31_06150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1486"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX10304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="284" mass="31007" checksum="E6D15E7EA7F2B92A" modified="2016-06-08" version="1">MRLYRDRAVVLRQHKLGEADRIVTLLTRDHGLVRAVAKGVRRTRSKFGARLEPFAHIDVQLHPGRNLDIVTQVQAIDAFAADIVSDYGRYTSACAMLETAERLAGEERAPMPALHRLTVSALRAIADGSRERELVLDAYLLRAMGVAGWAPALTECARCAAPGPHRAFHVAAGGSVCVHCRPSGSATPPQPVLELMAALHDGDWEYAETTSPGHRSQASGLIAAHLQWHLERQLRTLPLVERVYRIDRTVADQRAALVRQDMAHGFEAGREAGQDHLPTAAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ41</accession>
    <name>A0A132PJ41_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_20570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852250.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05985"/>
    <dbReference type="EnsemblBacteria" id="KWX22356">
        <property type="protein sequence ID" value="KWX22356"/>
        <property type="gene ID" value="AFM11_20570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1451"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102025">
        <property type="term" value="F:ABC-type thiosulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03296">
        <property type="entry name" value="ABC_CysA_sulfate_importer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005666">
        <property type="entry name" value="Sulph_transpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024765">
        <property type="entry name" value="TOBE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12857">
        <property type="entry name" value="TOBE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00968">
        <property type="entry name" value="3a0106s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="9"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="355" mass="38305" checksum="1FE033811B800413" modified="2016-06-08" version="1">MTNSGTDAIVVRGANKHYGSFAALDNIDFEVPAGSLTALLGPSGSGKSTLLRAIAGLDQPDTGTITIDGRDVTGVPPQRRGIGFVFQHYAAFKHLSVRDNVAFGLKIRKRPKAEIKERVDNLLEVVGLSGFQTRYPNQLSGGQRQRMALARALAVDPQVLLLDEPFGALDAKVRDDLRTWLRRLHDEVHVTTVLVTHDQAEALDVADRIAVLNKGRIEQVGSPTQVYDEPANAFVMSFLGAVSELNGILVRPHDIRVGRNPEMAIAAGDGTAEVTGVLRATIDRIVMLGFEVRVELTSATNNVPFTAQITRGDAEALGLKEGDTVYVRATRVPQIAGDVQVVVRSTDEDQALTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJA9</accession>
    <name>A0A132PJA9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19995</name>
        <name evidence="4" type="ORF">AWC31_28520</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000016">
        <property type="protein sequence ID" value="ORX14044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851881.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28520"/>
    <dbReference type="EnsemblBacteria" id="KWX22438">
        <property type="protein sequence ID" value="KWX22438"/>
        <property type="gene ID" value="AFM11_19995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14044">
        <property type="protein sequence ID" value="ORX14044"/>
        <property type="gene ID" value="AWC31_28520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1334"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX14044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="206" mass="22075" checksum="B611BE48F1CEB275" modified="2016-06-08" version="1">MGDTPRQEELDLTTGSGAEPPVRVSSEPVQAGLFPDDSVPDELVGYRGPSACQIAGITYRQLDYWARTSLVVPSIRGAAGSGSQRLYSFKDILVLKIVKRLLDTGISLHNIRVAVDHLRQRGVQDLANITLFSDGTTVYECTSAEEVVDLLQGGQGVFGIAVSGAMRELTGAIADFPGERADGGESIATPEDELASRRKSRDRKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJF4</accession>
    <name>A0A132PJF4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851837.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11100"/>
    <dbReference type="EnsemblBacteria" id="KWX22394">
        <property type="protein sequence ID" value="KWX22394"/>
        <property type="gene ID" value="AFM11_19760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1286"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453318" evidence="1">
        <location>
            <begin position="25"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="37"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="349" mass="36374" checksum="720ACDF95472AB08" modified="2016-06-08" version="1">MRFTTKVAAIASAGVLGLGMTACGAGDPEANSDSTRIGVTVYDMSSFITEGKEGMDAYAKAKNIELVWNSANNDVSTQASQVDSLINQGVDAIIVVPVQADSLGPQVASAKAKNIPLLAVNAALETPDLAGNVQPDDVAAGAQEMQMMADRLGGRGNIVILQGPLGGSGEINRGKGIDQVLAKYPDIKVLAKDTANWKRDEAVNKMKNWISSFGNQIDGVVSQNDDMGLGALQALKEAGRTGVPIVGIDGIEDGLNAVKSGEFIGTSLQNGTVELSAGLAVADALVKGEEVKTDPVYVMPAITKDNVDVAIQHVVTERQKFLDGLVELTEQNLKTGDIAYEGIPGQTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJY3</accession>
    <name>A0A132PJY3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_19310</name>
        <name evidence="5" type="ORF">AWC31_15395</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851687.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15395"/>
    <dbReference type="EnsemblBacteria" id="KWX22646">
        <property type="protein sequence ID" value="KWX22646"/>
        <property type="gene ID" value="AFM11_19310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17809">
        <property type="protein sequence ID" value="ORX17809"/>
        <property type="gene ID" value="AWC31_15395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1195"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453334" evidence="2">
        <location>
            <begin position="38"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="3">
        <location>
            <begin position="127"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX17809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="261" mass="26673" checksum="29FC6185662BE027" modified="2016-06-08" version="1">MAAVRVPACLRVGAAVVSSVLIAVTAPALVNSPLANAAPNVAGMIVFLDPGHNGANDASISRQVPTGRGGTKNCQESGTSTADGYPEHTFTWDTTLRVRAALTALGVRTAMSRGNDNALGPCVDERAAMANSLRPNAVVSIHADGGPANGRGFHVLYSSPPLNQVQAGPSVQFAKTMRDQLSASGIPPATYIGSGGLDARSDIAGLNLAQFPSILVECGNMKNPVDSALMKSPEGRQKYADAIARGIVGYLGSQTAAAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK55</accession>
    <name>A0A132PK55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851812.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22730">
        <property type="protein sequence ID" value="KWX22730"/>
        <property type="gene ID" value="AFM11_19285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1190"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="132" mass="13871" checksum="3D6696170237AC14" modified="2016-06-08" version="1">MRYPTAISELLAFAVADIGPGTAAIRVETDPARHGNQQGTIHGGFLVELADAAIGTAHSTLMRPGESFTSIDIRATFLRPVWADVLVATARPVHSGRTITHYTCDIVRGDGKTAATVTSTVMTLRGAQAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKB0</accession>
    <name>A0A132PKB0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851117.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11800"/>
    <dbReference type="EnsemblBacteria" id="KWX22779">
        <property type="protein sequence ID" value="KWX22779"/>
        <property type="gene ID" value="AFM11_17680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.891"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="24035" checksum="82EB762CA97CE9D5" modified="2016-06-08" version="1">MLSAIAIVPAAPVIVPELMGGAAAEMAGLRKAVLAAAGALPAHWLAVGAGPADAVLGPERAGTFAGYGVDVPVALSPDSEPAPTELPLCALIAGWIRGQTDARAVADVRVFADACPADAAVAHGRRLRAEIDESVEPVGVLVVADGANTLAPAAPGGYVPESVALQRDLDDALAGGDVAALTRLPDGIVGRVGYQVLAGLAEPGPQAARELYRGAPYGVGYFVGVWDPAGRSEATWGSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKR1</accession>
    <name>A0A132PKR1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851441.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12190"/>
    <dbReference type="EnsemblBacteria" id="KWX22928">
        <property type="protein sequence ID" value="KWX22928"/>
        <property type="gene ID" value="AFM11_18120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.981"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020948">
        <property type="entry name" value="P_starv_induced_PsiE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06146">
        <property type="entry name" value="PsiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="167" mass="18498" checksum="BCD62DBC6CF08FD7" modified="2016-06-08" version="1">MATREHTEGEQERERFADRALRIAEDTVYWSIAVLLLAGCVVLIVAQVNVIPRLRDNPATTIMLELLDGLLLVFIFVELLYAVRTSLRSRELVAEPFLIVGILACIKEIVVLSVDAAKLLDKGPEFARAVVQVGVLGGLVLVLAAAIFVLRLQRRNADHMRDKPDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKU0</accession>
    <name>A0A132PKU0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_18230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851302.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12300"/>
    <dbReference type="EnsemblBacteria" id="KWX22864">
        <property type="protein sequence ID" value="KWX22864"/>
        <property type="gene ID" value="AFM11_18230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1003"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="51"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="351" mass="37415" checksum="D119E9E2FA4E2662" modified="2016-06-08" version="1">MNLAQIANPPATSDRRIRSFSAIPSPHDVLTEFPLGARRAERVARDRDEIADILAGRDDRLLVVVGPCSVHDPAAALEYASRLVKVADELKDRLKVVMRVYFEKPRTTIGWKGLINDPGMDGTFDVARGLRIARQLLLDIIDIGLPVGCEFLEPTSPQYIADAVAWGAIGARTTESQVHRQLASGLSMPVGFKNGTDGNIQVAVDGVKAAAAEHVFFGMDDLGRGAVVSTEGNEDCHVILRGGTDGPNYGTESVSDAAAKLSKAGLPGRVVIDCSHANSGKDHVRQAVVATEVAAMVRDGAPVSGVMLESFLVGGAQAPEARPLTYGQSVTDKCMDWATTDLVLRELAKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKX0</accession>
    <name>A0A132PKX0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850677.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22991">
        <property type="protein sequence ID" value="KWX22991"/>
        <property type="gene ID" value="AFM11_16585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.666"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00667">
        <property type="entry name" value="ring_hydroxylating_dioxygenases_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000391">
        <property type="entry name" value="Rng_hydr_dOase-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41534">
        <property type="entry name" value="PTHR41534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00866">
        <property type="entry name" value="Ring_hydroxyl_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="177" mass="19835" checksum="B117FCB7ECC54BD2" modified="2016-06-08" version="1">MTTTELNVSAARIDVPRIDKDAVEAFIYHEVDLLDQRKFADWLALFTDDAHYWIPSGFDDLDPSRSVSIVYDDHQLLTERAQRLTGTLAYAQIPPSRTAHVVGNVQLLEVATADDGTATARVQAKFAVAEFRRNTRFLHAGRVSYTLVDFGAGLRIRLKKLELIDNDGYLGNLSMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL02</accession>
    <name>A0A132PL02_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FO synthase</fullName>
            <ecNumber evidence="9">2.5.1.147</ecNumber>
            <ecNumber evidence="8">4.3.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">fbiC</name>
        <name evidence="19" type="ORF">AFM11_16745</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:55200"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="2.5.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the radical SAM superfamily. CofH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the radical SAM superfamily. CofG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.147" evidence="9"/>
    <dbReference type="EC" id="4.3.1.32" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850740.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01315"/>
    <dbReference type="EnsemblBacteria" id="KWX23018">
        <property type="protein sequence ID" value="KWX23018"/>
        <property type="gene ID" value="AFM11_16745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.702"/>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00293">
        <property type="entry name" value="((2_3_4_5-tetrahydroxypentyl)a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03551">
        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="86"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="547"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KWX23018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="859" mass="93261" checksum="20EE4A415756DE26" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL05</accession>
    <name>A0A132PL05_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16815</name>
        <name evidence="4" type="ORF">AWC31_01385</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850764.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01385"/>
    <dbReference type="EnsemblBacteria" id="KWX23030">
        <property type="protein sequence ID" value="KWX23030"/>
        <property type="gene ID" value="AFM11_16815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13213">
        <property type="protein sequence ID" value="ORX13213"/>
        <property type="gene ID" value="AWC31_01385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.716"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="300"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX13213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="387" mass="40764" checksum="B9AC30F5646B5C39" modified="2016-06-08" version="1">MTAPKARGSEWHWLWKAYVAGLLVVAMVAVVLLQGRFGGHVVLAVAALAAILVIIAAVGDQIIRSDETTWRTVLFIVVVVALWVLAMWASPVAVAAIPALYPLFFATLPLAAALAVTTVVNLVPLSLTLLGDIRSPNLPLAIAITAIGVVSAPVIGTVIMTSMKQRRMLADVVSELAASRAESARLSRLAGAAAERERLSREIHDTLAQGFTSIVALAQAVQVELETDRAAAVDHVELIESTARENLAEARIMVADLTPAALGDDSLPAAIRRQCRRLTAETGIPVTVHVDEQLPALGMATDVVLLRAAQEALANIRQHAHASAVEVTLRAEADSVRLTLSDNGIGLPHDHQDGFGLQGIRARVGQAGGTVDVSSHAGVRIDIEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLB2</accession>
    <name>A0A132PLB2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_16890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850792.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01460"/>
    <dbReference type="EnsemblBacteria" id="KWX23044">
        <property type="protein sequence ID" value="KWX23044"/>
        <property type="gene ID" value="AFM11_16890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.731"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="340"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="537" mass="58160" checksum="6FE86E4B0D591094" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLF4</accession>
    <name>A0A132PLF4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850874.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23084">
        <property type="protein sequence ID" value="KWX23084"/>
        <property type="gene ID" value="AFM11_17135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.780"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016865">
        <property type="entry name" value="RclC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007339">
        <property type="entry name" value="RclC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40106">
        <property type="entry name" value="PTHR40106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04224">
        <property type="entry name" value="DUF417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028065">
        <property type="entry name" value="UCP028065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="163" mass="17158" checksum="F5F71CEC8EA76740" modified="2016-06-08" version="1">MAVGSVTRVGQTVSRYGLVVVLAWIGFGKYVKMESRVLIEHSPLMSWIYQFLSVGTVAAALGTMEIVAAVLIAIRPFWPAVSAYGSALAVVLFVGTLSFLFTTPGIVATYAGPLPVLSGMPGQFLLKDLVLIGVALWTLGDSLEAARRRSSAASRSGPASAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLR8</accession>
    <name>A0A132PLR8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850266.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16250"/>
    <dbReference type="EnsemblBacteria" id="KWX23233">
        <property type="protein sequence ID" value="KWX23233"/>
        <property type="gene ID" value="AFM11_15535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7223"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="128" mass="13117" checksum="91B26EC5732D140C" modified="2016-06-08" version="1">MADAGTWTELTDGGEPTVRISAPDLAQARRLRTRIRSEDAGASVVLDVTVAVAGDYRSARRGLELAGSDANVRYVGTVDGLAGLIADIESAGVADGVTLLPATPGSDLGALAADVLRRLEARSQARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLT9</accession>
    <name>A0A132PLT9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_15430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850225.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16345"/>
    <dbReference type="EnsemblBacteria" id="KWX23214">
        <property type="protein sequence ID" value="KWX23214"/>
        <property type="gene ID" value="AFM11_15430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7201"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="327" mass="36235" checksum="8DF4D5C07514F9AE" modified="2016-06-08" version="1">MSDQLLSVRDLRKSFRVGKNRLAALDGITLDLARGETLGLVGESGCGKSTLARTLMMLERPDSGSVTFDGIDPFGLRGKDLLKFRRRVQMVFQDPYASLNSRMTAGDIIAEPWRTHKTLYPNRKDREMRIRGLLDMVGLGAKAANKYPQEFSGGQRQRIGIARALALNPDVIICDEPVSALDLSVQAQVLNLLNDLQQELQISYIFISHDLSVVRHVADRVTVMYLGRMIESGSTEDVYQHPRHPYTAALMSAAPKLDAAQRNDRILLSGEVPSPLNPPSGCRFRTRCWQATEICATQAPDPRFDAEAADHMSECHHPLQSAVPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLZ3</accession>
    <name>A0A132PLZ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_16825</name>
        <name evidence="5" type="ORF">AWC31_01395</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850768.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01395"/>
    <dbReference type="EnsemblBacteria" id="KWX23032">
        <property type="protein sequence ID" value="KWX23032"/>
        <property type="gene ID" value="AFM11_16825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13215">
        <property type="protein sequence ID" value="ORX13215"/>
        <property type="gene ID" value="AWC31_01395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.718"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="297"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="465"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX13215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="525" mass="55894" checksum="28B7E5FC351D7D9B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM23</accession>
    <name>A0A132PM23_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23389">
        <property type="protein sequence ID" value="KWX23389"/>
        <property type="gene ID" value="AFM11_16300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7385"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="219" mass="22652" checksum="8349F8327C52F80C" modified="2016-06-08" version="1">MVTAAILAVAFVVAPAVLAGGGYGSFYDNQPLVDALDKSFAAYWRSGVRTSDLQDLVDYWLWYHVAKAAFAAGLLAVLAVLCLRSRRTWGRAVTAVLAVGATILTMANVQGAAAPFASLLPMLSDEARQAHSVVGDAHETALAVMVGDFARYHAVLAGLAALVAAVLIVVVAVCLRRRLPVGFTASTAALSALMLVVVAANVTNAVAPEEGLQVFLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM39</accession>
    <name>A0A132PM39_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_14080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849705.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09390"/>
    <dbReference type="EnsemblBacteria" id="KWX23418">
        <property type="protein sequence ID" value="KWX23418"/>
        <property type="gene ID" value="AFM11_14080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6920"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="379" mass="40343" checksum="BDC581A7D7529052" modified="2016-06-08" version="1">MPVDRLLPSDEAHELIALTRDIADKVLDPIVDQHEKAETYPEGVFAQLGAAGLLSLPQPEEWGGGGQPYEVYLQVLEEIAARWAAVAVAVSVHSLSSHPLLTFGTEEQKARWLPGMLSGEQVGAYSLSEPQAGSDAAALRCAAKRSDDGYVINGSKSWITHGGRADFYTLFARTGEGSKGISCFLVPGTLDGLSFGKPEEKMGLHAVPTTSAFYDNAVIDADRLIGAEGQGLSIAFSALDSGRLGIAAVAVGIAQAALDEAVRYANERTTFGRKIIDHQGLGFLLADMAAAVVSARATFVDAARRRDQGLPYSTQASVAKLVATDAAMKVTTDAVQVLGGVGYTRDFRVERYMREAKITQIFEGTNQIQRLVISRGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM99</accession>
    <name>A0A132PM99_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849790.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09025"/>
    <dbReference type="EnsemblBacteria" id="KWX23459">
        <property type="protein sequence ID" value="KWX23459"/>
        <property type="gene ID" value="AFM11_14330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6974"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="105" mass="10702" checksum="2E9408E35E5A3DAB" modified="2016-06-08" version="1">MSGDLRVTTAHLRELSAKQGEAAAVLTSATAAVDGVDSAVRWTHGPISWSTAAAVEAAQNARRIAGTGMANVSQDLGEKLTSAAGRYDNTDMTTAEALDGTVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMG1</accession>
    <name>A0A132PMG1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849886.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23505">
        <property type="protein sequence ID" value="KWX23505"/>
        <property type="gene ID" value="AFM11_14630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7035"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453411" evidence="1">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="25909" checksum="16590E36B13AE06A" modified="2016-06-08" version="1">MRLRVIAAALLVGGCTTPQPSAPPPAPVDPRALSHFTIVWSDPAGLDLLSAEGTYLRASVESLRLAAANSNRDAAYPGFWETLTGPAKDYAESFFALGPDDALHGVNRFEVIGVADHDDRLTAGLCIYERQLGVEDTDGRFTFNRMGSHYWELTVEKAGEASPPAGQRGRDTYPQAAMFGSWRTVKWSRQPADTPNPCAGRPTPGVEPGAWPALMPGSRPYVTEDVPTAPNYPGWLNNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMM7</accession>
    <name>A0A132PMM7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849988.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17975"/>
    <dbReference type="EnsemblBacteria" id="KWX23553">
        <property type="protein sequence ID" value="KWX23553"/>
        <property type="gene ID" value="AFM11_14925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7096"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="DUF839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="690" mass="73482" checksum="36474D556B5942E5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMN4</accession>
    <name>A0A132PMN4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_14455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850083.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18370"/>
    <dbReference type="EnsemblBacteria" id="KWX23598">
        <property type="protein sequence ID" value="KWX23598"/>
        <property type="gene ID" value="AFM11_14455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6999"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="415"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="487" mass="51731" checksum="12A1090A4E8773F8" modified="2016-06-08" version="1">MGFVDRIERKLESTVGDAFARVFGGSIVPQEVEAALRREAESRARTVAGGQVLAPNEYVITLSGTDYQKVSADTDLTSTAFAKHLGGFIRDQGWQTYGDVVVRFEQSPNLHTGQFRAHGAVNPDSTASESARAQRDHAFTAESGEPPMTDNPNYRGGQGQGRPGDDYYDDRYGRQQDDPRGGQYPPEQGGYPPQDQGGYPPRGGYPEQGGYPDQGGYPEQGGYPDQGGYPDQGGYPDQGGYPPQSYEQRPPAGGGYGQPGGGYDQPAGRGYGQQPGGYGPPPGGQPGYGGPAGDYDYGRQPAPGRHDDYGRQEPRPGGGGYPEQGGYGGQSYGRPEYGQQPDYGRGYSEPAPGGYPDQGYGEPAGRDYDYGAPGGGQAGYGGGYGAGDYQAGGATVTLQLDDGSGRTYQLREGANVIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLSDLNSTNGTTVNNAPVQEWQLADGDVIRLGHSEIIVRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMQ9</accession>
    <name>A0A132PMQ9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="4" type="ORF">AFM11_14790</name>
        <name evidence="5" type="ORF">AWC31_18110</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18110"/>
    <dbReference type="EnsemblBacteria" id="KWX23605">
        <property type="protein sequence ID" value="KWX23605"/>
        <property type="gene ID" value="AFM11_14790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17305">
        <property type="protein sequence ID" value="ORX17305"/>
        <property type="gene ID" value="AWC31_18110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7069"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="124"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX17305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="235" mass="25205" checksum="013612512C3A64EE" modified="2016-06-08" version="1">MKHEPAPVAPEAAGVVFGDRLPAAERYAALLATAGVERGLIGPREVDRIWDRHILNSSALGELVVAGERVADIGSGAGLPGIPLALARPDVHVTLIEPLLRRSEFLREVVAELDLSVAVVRGRAEDRVVREQAGEMDVVTSRAVASLDKLARWSMPLLREGGRMLAIKGERAEAEIEEFRRVMASLGAADARVVRCGANYLNPPVTVVDARRRASNRGRQGPAGKAGPRGRAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN79</accession>
    <name>A0A132PN79_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_13130</name>
        <name evidence="7" type="ORF">AWC31_03415</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849241.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03415"/>
    <dbReference type="EnsemblBacteria" id="KWX23724">
        <property type="protein sequence ID" value="KWX23724"/>
        <property type="gene ID" value="AFM11_13130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11184">
        <property type="protein sequence ID" value="ORX11184"/>
        <property type="gene ID" value="AWC31_03415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6719"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX11184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="234" mass="26170" checksum="ADEBBE771AC8DD45" modified="2016-06-08" version="1">MAQQTPQAAVKTDGRKRRWHQHKVERRNELVDGTLEAIRHRGSNVSMDEIAAEIGVSKTVLYRYFVDKNDLTTAVMMRFAQTTLIPNMAAALSSNLDGFDLTREIIRVYVETVAAEPEPYRFVMANNSASKSKAVADSEQIIARMLAVMLRRRMAEAGMDTAGAEAWAFHTVGGVQLATHSWMSNPRMTTDELIDYLTMLSWYALCGIVEVGGSLEKFNSQPHPSPVPPRRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNS8</accession>
    <name>A0A132PNS8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848279.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23990">
        <property type="protein sequence ID" value="KWX23990"/>
        <property type="gene ID" value="AFM11_11515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6379"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="64"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="256" mass="26704" checksum="584AF6A6AB3DD615" modified="2016-06-08" version="1">MATTALRGLQMLETLAGMRQPATLRDIADRAGLSESNAFRILQALEQEGYLHHLGRSGYRLASRSLALATVIGPRPAMLRLMYPVVARLAGISGEAAVIHLRAGHFRVLVLGVPARSGPILDPAGVLGERTPLASGASGRIILAYLTEAERAGIDLGGVTPQQLAAIRERGYETSHGENHPGINGISVPLLAETDDAACPPIALGAMTIAGPAERFPDEGLLRLAGPLMGACRDLSPRLAALLGPNPGSTIDALDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP22</accession>
    <name>A0A132PP22_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ornithine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848575.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09920"/>
    <dbReference type="EnsemblBacteria" id="KWX24088">
        <property type="protein sequence ID" value="KWX24088"/>
        <property type="gene ID" value="AFM11_12055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6490"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="3">
        <location>
            <begin position="7"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="4">
        <location>
            <begin position="409"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="485" mass="52871" checksum="9CB43C8F1A67985A" modified="2016-06-08" version="1">MNQSEAPLLDALNSYHASNRYGFSPPGHRQGRGVDERVLRVLGREPFLSDVLASGGLDDRRSSNGYLTRAEDLMAEAVGADVAWFSTCGSSLSVKAAMMAVAGGDGSLLLSRDSHKSVVAGLIFSGVTPRWITPRWDAERHMSHPPSPQQVEETWQRYPDAAGALIVSPSPYGTCADLEGIAEVCHARGKPLIVDEAWGAHLPFHEDLPTWAMNAGADVCVVSVHKMGAGFEQGSVFHLQGDLVDQDRLSQCADLLMTTSPNVLLYTAIDGWRRQMVQRGHELMGAALELAERTRHQIEKIPDIEVLDDELLGVQASHDLDRLQVLIDVAATGTSGYQAADWLREYCQVDMGMTDHRRILATMSFADGADTAGRLIDALTLWRKAADDFDRPPRVDLPSPEEIQLTTVTSPRDAFFGRVEKVPVEEAAGRISAEQITPYPPGIPAVVPGERLNRAVLDYLRTGLEAGMNLPDPADPQLRTVRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP88</accession>
    <name>A0A132PP88_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminopyrimidine aminohydrolase</fullName>
            <ecNumber evidence="1">3.5.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:31799"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:63416"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17509"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TenA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.2" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848594.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09875"/>
    <dbReference type="EnsemblBacteria" id="KWX24094">
        <property type="protein sequence ID" value="KWX24094"/>
        <property type="gene ID" value="AFM11_12100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6499"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026285">
        <property type="entry name" value="TenA_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003170">
        <property type="entry name" value="Pet18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="4">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003170-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR003170-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="185" mass="21085" checksum="3EB063780C394A5A" modified="2016-06-08" version="1">MSDELWTTATRHPFLDAVRDGTITDAAFDRWLCQDAIFVADLLTFQARLLARAPRRAQTTLAAGCAALVAELDWFNEQARRRGLQMTQEALPATLAYRKLLDRLDAEPFETAVTALWVVERVYLLAWTHAASETSKFRDFVEHWTTPEFGDYVDALGELAVTHGNDEVVREVLEHEVAFWDMAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPC6</accession>
    <name>A0A132PPC6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05920"/>
    <dbReference type="EnsemblBacteria" id="KWX24190">
        <property type="protein sequence ID" value="KWX24190"/>
        <property type="gene ID" value="AFM11_09305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5898"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="43"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="192" mass="20207" checksum="2EE9304482ECC745" modified="2016-06-08" version="1">MSEQDRMRWDATYAGRCEAVAEPAPPAVFAARESVFPVTGTALDIACGAGFGSVWLARRGLQVWGVDLSAVAIDHAEALAARYGVADRCRFDVVDLDGGLPAGPAVDVILCHRFRDPGLYPAMIERLTPAGILAISVLSEVGREPGRFRAVPGELLAAFGGLEVIDAGEGGGEAWLLARSPGDGRRPPGLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPR8</accession>
    <name>A0A132PPR8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847477.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18610"/>
    <dbReference type="EnsemblBacteria" id="KWX24330">
        <property type="protein sequence ID" value="KWX24330"/>
        <property type="gene ID" value="AFM11_10140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6064"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="17611" checksum="E54504ACB9111C18" modified="2016-06-08" version="1">MARRRKDMPPPATGGSERDVLLGFLDYLRECVIAKVQGAPEPHVRQPGVPSGTNLLGLLNHLVNVERFTFLGEAVADWPATFHAAADSTVQSLTAEYERVTAQANEAIESCADLESPCARPTRQGQPPSMRWALTHMIEETGRHAGHMDILRELIDGSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPZ2</accession>
    <name>A0A132PPZ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847742.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19185"/>
    <dbReference type="EnsemblBacteria" id="KWX24416">
        <property type="protein sequence ID" value="KWX24416"/>
        <property type="gene ID" value="AFM11_10670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6174"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="401" mass="45342" checksum="AAA2277A72048772" modified="2016-06-08" version="1">MTKPQVIFDPFSEDYFNNPFDIYRQMREEAPLYYSAEQDFYALTRHEDVAAALKDHEAFSSSRGCDLAMVQGDEPPQKSIIFMDPPDHRHMRSLLNKAFTPRAIQAQKDTIVEQIDHYLGMIDSDEFDIVQDFSGPFPVEVITRMAGVDPEYRQQVRHWIDTSLSREPGQIGYSEAGIQANIDTAIYYYSLVQKRREHPQDDMISRLIAAEIPGEDGQMRRLDDIEITGFATLLGGAGAETVTKLVGTAMVLFARHPEQWQKLLDDRDKVPAAVEELLRYEGPVQYNVRYTLKEAHVPSGTIPAGKPVFLISAAANRDPDAFTNADAFDIDRNRTEAQNLGLGYGIHSCLGAALARMESAIALEKLLDFMPRYEVQWDGLQRVHMQNVAGYSHVPVRVLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQA6</accession>
    <name>A0A132PQA6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847649.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18930"/>
    <dbReference type="EnsemblBacteria" id="KWX24387">
        <property type="protein sequence ID" value="KWX24387"/>
        <property type="gene ID" value="AFM11_10495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6139"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="430" mass="48185" checksum="60A2037C76A8184F" modified="2016-06-08" version="1">MTEAATPDYDSIDYFTDPSLVPDPHPYFDHLRSKCPVVREPNYGVLAITSFEEATHVLKDTDTFSSCIAVAGPFPPLPFTPEGDDITEQIAEHRPQMPMFEHMVTMDPPDHTNARSLLNRLLTPRRLKENEDFMWRLADQCLDDFIADGKCEFLSAYAKPFSLLVIADMLGVPEEDHEEFRTVLGAPRPGAQVGSLDGDLVSSNPLEWLDEKFIGYLEDRRKTPRDDVLTALATANYPDGSVPPVIEVVRSATFLFAAGQETTTKLLSASLRVLGDRPDVQEALRQDRSRIPTFVEEALRMDAPVKSQFRLAKKHTQLGGVDVPAGTTLMVCPGAVNRDPVRFEDPHTFSLDRKNVREHIAFGRGVHSCPGGPLARVEGRVSIERILDRMADISIDEEYHGPADDRRYTYEPTFILRGLTDLHITFDPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR20</accession>
    <name>A0A132PR20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_09030</name>
        <name evidence="10" type="ORF">AWC31_13340</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846747.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13340"/>
    <dbReference type="EnsemblBacteria" id="KWX24788">
        <property type="protein sequence ID" value="KWX24788"/>
        <property type="gene ID" value="AFM11_09030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18565">
        <property type="protein sequence ID" value="ORX18565"/>
        <property type="gene ID" value="AWC31_13340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5656"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX18565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="393" mass="43286" checksum="1C7B6C85721535E3" modified="2016-06-08" version="1">MRIGYTPEQEELRRELRAYFSQLMTPDRVEALNSSEGEMGRGNVYRDTVAQMGKDGWLTLSWPKEFGGQARPPMDGLIFTDEAAIAGAPVPFLTINSVAPTIMHFGTEEQKKFFLPKIAAGELHFSIGYSEPGAGTDLAALRTTAVRDGDDYVINGQKMWTSLIAYADYVWLAVRTNPEAKKHRGISMLIVPTTAEGFSWTPVHTMSGVDTSATYYQDVRVPVSNLVGEENAGWKLVTNQLNHERVALVSAQPIYVALNGVREWAQNTKDVHGKRLIDSEWVQLNLARVHAKAEVLKLINWELASAQDAAPSPADASAAKVYGTELATEAYRLLMEVLGTSATLRADSRGALLRGRIERFHRSALILTFGGGTNEIQRDIIGMVALGLPRVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR26</accession>
    <name>A0A132PR26_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_10700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847975.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19215"/>
    <dbReference type="EnsemblBacteria" id="KWX24502">
        <property type="protein sequence ID" value="KWX24502"/>
        <property type="gene ID" value="AFM11_10700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6180"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="187" mass="20505" checksum="B22DB1B1177FD66F" modified="2016-06-08" version="1">MQAAMALWRTNGYARTTVADICRAAGVSRALFYFYFPAKEDVLFEVGLLSTRAAQKRVQSLLNSDYEVVPVIAEALRSLERSMARNPPELIIETILEGYRHEHRILTGDADPDALSADMFGELFTRAQADGKLAAHVDVTHLSHLAQILVSEGVRHWAGGSYGDRSFSDVVTGDIAALVAGFNIVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRH1</accession>
    <name>A0A132PRH1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845779.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12850"/>
    <dbReference type="EnsemblBacteria" id="KWX24895">
        <property type="protein sequence ID" value="KWX24895"/>
        <property type="gene ID" value="AFM11_05475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4284"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="12"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="233" mass="24844" checksum="2E9FE247E1FB1E5E" modified="2016-06-08" version="1">MLITGFPAGMLACNCYVVAERPGADAIIVDPGQRAMGPLRRILDENRLTPAAVLLTHGHVDHIWSAQKVADTYGCPAYIHPEDRFMLTDPIKGFGPRLAQLAFGVLFSEPKQLVELDRDGASVELGGITVAVDHTPGHTRGSVIFRVAGGQERSDRGFGTAGPSDVVFTGDTLFRSSVGRTDLPGGSGRDLLGSIVTKLLVLDDDTVVLPGHGPRSTIGHERRTNPFLEGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRK7</accession>
    <name>A0A132PRK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845139.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11765"/>
    <dbReference type="EnsemblBacteria" id="KWX24969">
        <property type="protein sequence ID" value="KWX24969"/>
        <property type="gene ID" value="AFM11_05905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4372"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="166" mass="18147" checksum="27F97165842E5DE2" modified="2016-06-08" version="1">MNTPTLIASLVMAAVLALLIAFLIRQMMRGWLHRAQRQAELIGTLPELPDTVGQATVPATKGLYVGSTLVPHWNDKVAAGDLGFRAKAVLTRYPEGIMMQRSGAGPIWIPAESITAIRTERGIAGKALTYDGILAIRWRLPSGAEIDTGFRADNRAELDRWLEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRZ2</accession>
    <name>A0A132PRZ2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06565</name>
        <name evidence="5" type="ORF">AWC31_29110</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845343.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29110"/>
    <dbReference type="EnsemblBacteria" id="KWX25080">
        <property type="protein sequence ID" value="KWX25080"/>
        <property type="gene ID" value="AFM11_06565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13844">
        <property type="protein sequence ID" value="ORX13844"/>
        <property type="gene ID" value="AWC31_29110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4508"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX13844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="396" mass="42794" checksum="A952B48F9635E7F7" modified="2016-06-08" version="1">MEGAVAGLVLLIVLVVFAIIIVAKSVALIPQAEAAVIERLGRYSKTVSGQLTLLVPFIDKIRARVDLRERVVSFPPQPVITEDNLTVNIDTVVYFQVTNPQAAVYQISNYIVGVEQLTTTTLRNVVGGMTLEQTLTSRDQINGQLRGVLDEATGRWGLRVARVELRAIDPPPSIQESMEKQMKADREKRAMILTAEGVRESSIKQAEGQKQSQILAAEGAKQAAILAAEADRQSRMLRAQGERAAQYLQAQGQAKAIEKTFAAIKAGRPTPEMLAYQYLQTLPQMAKGEANKVWLVPSDFGAALQGFTKLLGAPGEDGVFRYTPSPVDEDLPKPEDDSDEVADWFSTDTDPEIAQAVAKAEAEARKPTPPLGSAPVNPSLGVPPSPELPGGAHRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS02</accession>
    <name>A0A132PS02_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PE-PPE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845358.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29055"/>
    <dbReference type="EnsemblBacteria" id="KWX25090">
        <property type="protein sequence ID" value="KWX25090"/>
        <property type="gene ID" value="AFM11_06620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4521"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013228">
        <property type="entry name" value="PE-PPE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08237">
        <property type="entry name" value="PE-PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453534" description="PE-PPE domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PE-PPE" evidence="3">
        <location>
            <begin position="67"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="372" mass="38698" checksum="14F6A189E019316B" modified="2016-06-08" version="1">MNRLFAAAVAAGLVGSVTAFGSGVASAETAFIVPGTAPSPYPALRALYHFDPATQPAIGANYYDSAGATREVVPYPGSLWPLTGENSPTLAQSVADGTNSLDSRIRSADGNVTVTGLSQGVLALNAEQARLANDPTAPAPDNLTFVKTGNPDRLFTKWFRPGTTVPVLDYTVPAPIESQYDTVEVVAQYDIFSDPLDRPGNLLALANALVAGGTSHTATAFSDPASIPAQNVTVATNSRGATTTTYFIPAEQLPLVEYLSQGGMSPEMAAELNRYLTPMVNRAYGPPPPPVEPGVRLADLRGIAPGNIATPISVPINAVSTATNVASNAVNAVNIANQVRNLLPKNGVQLPKNGLPLPKKGIPLLPKGKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS12</accession>
    <name>A0A132PS12_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845381.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25100">
        <property type="protein sequence ID" value="KWX25100"/>
        <property type="gene ID" value="AFM11_06680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4535"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453240" evidence="1">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="153" mass="15856" checksum="5040E6C0C39D90B5" modified="2016-06-08" version="1">MRQHFIAGAAIGVLGLAAAPAAAADPPVGADDIDRYPVAQGHYSSPTDFYGVFFKTPDGRACGIGPNGGPVGCDAVPIDAPPGMNQTVVNSGVAATYRFSDHPSFTRDVDVLPEGHRLENWGASCGVGYQGTVTCKTYGRHGFILSAGYGVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSF4</accession>
    <name>A0A132PSF4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25281">
        <property type="protein sequence ID" value="KWX25281"/>
        <property type="gene ID" value="AFM11_03010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="64" mass="6638" checksum="5EE5FB4B9C418ECC" modified="2016-06-08" version="1">MQDAADKKFEQFTVIIGTATTHVPSDGFGQYCRPIEGRAAVRGRDVGEVLAGCMGRAAGGGCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSU0</accession>
    <name>A0A132PSU0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25334">
        <property type="protein sequence ID" value="KWX25334"/>
        <property type="gene ID" value="AFM11_03350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2544"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="245" mass="24857" checksum="F190D34CBC83B187" modified="2016-06-08" version="1">MPATDSPVAVVTGGGSGIGRAAGLALARTGHRVVFCGRTGPKLHESVELAGSGEAAVIDVTDEAAVDVFFGGLTRLDVLVNSAGVFGTQQPVTGTSLAEWSATMSANVTGTFLCARAAMRLMAAQQPRGGRIINIGSVSAQVPRPHATPYTASKFAVSGLTRSLALEGRDLDIAVGQIDVGNAATTMTAGFETGSLQADGTVRPEPKIDVAHVGSTIAHIAGLPLAVTVPFLTIMATRMPLLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT43</accession>
    <name>A0A132PT43_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20660"/>
    <dbReference type="EnsemblBacteria" id="KWX25506">
        <property type="protein sequence ID" value="KWX25506"/>
        <property type="gene ID" value="AFM11_04490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2776"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453319" evidence="2">
        <location>
            <begin position="30"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="401" mass="41791" checksum="F39FB62C59B55027" modified="2016-06-08" version="1">METQEMVRVLALLSVIFLVAGCGGGSGDASDTAQGEPGAGTVVAEAPLDHLDQALRDAASSARGMTYRSRSGIDDDNTHVTGSVFVPKGNAPDGGFPVVALAPEVNGTAADCAASLSPNLGGNSGTVQELLKAGFVVFVPDYQGLGKPSDGKDIYHPYLDSTTAGYVIIDGVRAALTMVPEASTSWAALGNYQGGQAAWAANELVANYGSGLELVATASLSPIADFEGLADAAMAGTLTPEQKLIYVAFLAAVKNAYPYDFELDDYRRGNAEQHWDALMSCNESERMGLAAQIGPDDLKPASPEALAAIRGYLQKTTLPQGPTDAPMYVIYGGRDPAIPAAWTDSALTRACQMGDVVQIAFWPDQSHQGTSPVAALGWLGERFKSIPSANDCEAFLASHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT91</accession>
    <name>A0A132PT91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03900</name>
        <name evidence="3" type="ORF">AWC31_21265</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844256.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21265"/>
    <dbReference type="EnsemblBacteria" id="KWX25417">
        <property type="protein sequence ID" value="KWX25417"/>
        <property type="gene ID" value="AFM11_03900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16560">
        <property type="protein sequence ID" value="ORX16560"/>
        <property type="gene ID" value="AWC31_21265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2658"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="217" mass="23895" checksum="9EE30BA94CDA37E7" modified="2016-06-08" version="1">MGLFRAEGPHPGWPDCVGPLRVPAGVVRLRPVRLRDAATWSRIRLADREHLEPWEPVTGAEWTVRHAVSSWPAVCSGLRSEARRGRMLPYVIELDGQFVGQLTIGNVTHGALRSAWIGYWVASSKTGGGIATAALALGLDHCFTGVRLHRVEATVRPENARSRAVLARVGFREEGLLRRYLEVDGAWRDHLLVAITVEELSQPAAHALVQAGRARWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTA1</accession>
    <name>A0A132PTA1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04840</name>
        <name evidence="4" type="ORF">AWC31_20305</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844646.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20305"/>
    <dbReference type="EnsemblBacteria" id="KWX25568">
        <property type="protein sequence ID" value="KWX25568"/>
        <property type="gene ID" value="AFM11_04840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16399">
        <property type="protein sequence ID" value="ORX16399"/>
        <property type="gene ID" value="AWC31_20305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2849"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="41"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX16399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="264" mass="29862" checksum="BA204993A800F587" modified="2016-06-08" version="1">MDIIPPRLKEPAYRLYEMRLRQELARSKSELPRHIAVLCDGNRRWARDAGHDDVSIGYRMGAAKIAEMLRWCQAAGIEMTTVYLLSTENLQRDPEELSALIEIITDVVEEICAPANKWSVRTVGDLELLGDEPARRLREATERTASTASGTFHVNVAVAYGGRQEIVDAVRSLLSKELANGATAEQLIEAVTADGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAYWPAFRRVDFLRALRDYTARHRRFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTA9</accession>
    <name>A0A132PTA9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_04475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844511.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20675"/>
    <dbReference type="EnsemblBacteria" id="KWX25504">
        <property type="protein sequence ID" value="KWX25504"/>
        <property type="gene ID" value="AFM11_04475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2773"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="134"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX25504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="492" mass="53931" checksum="F96DA23E012AF378" modified="2016-06-08" version="1">MASGTKVDLDGLRRDIDALLGRLDDAERQWASWIERTVPEHRRSAVNLAHYWAIRQSDLRDMQGRLAELGLSSLGRSEAHVQATLKLVSAALKSMAGASYVPPDDVVVGVREGAELLLHNAADLLGPPPAERGVRIMVTLPSEAADDPQLIADLVDNGMNVARINCAHDDAAAWREMAAHVRKTSESCVIAMDLAGPKLRTGPLEPEDGALRLQRGDVLRVTRDCSPAPVETDDPWIGCTLPEVFERAEKGQRVLFDDGKLAGTIVEAKPDVLEVRIDHPALNSAKLKAGKGINVPDTELPISALTDKDIEDLGTVAEVADVVEFSFVRTADDIDKLFAELDRIGADHLGVVLKIETRPAFENLPQLVMAAMARRKVGVMIARGDLAVEVGYERMAELQEEMLWLCEAAHLPVIWATQVLEQLAKKGQPARSEVSDASMGVRAECVMLNKGPYIVDAVQTLAGILDRMEEHLYKKNTLLRTLRSWRPNHELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTI2</accession>
    <name>A0A132PTI2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_04495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844517.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20650"/>
    <dbReference type="EnsemblBacteria" id="KWX25507">
        <property type="protein sequence ID" value="KWX25507"/>
        <property type="gene ID" value="AFM11_04495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2777"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="202" mass="21959" checksum="98D50E9967DE8F7A" modified="2016-06-08" version="1">MPVSRAERRERLLRAAQTAVMKHGVDVQLKHVAAEAGLTPGAVLYHFPDIQTLLVEANRAGIERFYDARLRAIDGVAEPDRKLVITIESGLPTDSDDPDVKLMCALGGAAARYPAYAVMLTALYDRQVAMYQIILETGAAQGVFTLTSSSLTTARNIVALEDAYGYRMVARHPSLDAEAAIELICDYARVATGHPLPRPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTP5</accession>
    <name>A0A132PTP5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844926.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20665"/>
    <dbReference type="EnsemblBacteria" id="KWX25706">
        <property type="protein sequence ID" value="KWX25706"/>
        <property type="gene ID" value="AFM11_04485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2775"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="31616" checksum="8EE282CA69A6A329" modified="2016-06-08" version="1">MAQSVTTTDGRKLTYAEVGDPQGPLVIHNHGGPGSRYEAQFFAEAATTNRLRLICVDRPGMGGSTPQKARTYAGWADDLTSIADAMGYREFGVTGWSEGGPWALAAAAYIDPTRLRHVTSIAPGSYGAFGDNSAAQYLSKIDALGAALALRFKPGFRLMYAGLSLTAKHFGASFVKQTRAAVNDYDRQILLQPENESVFVDELAECFAQGSAGLVRDAELLYRRWAFDVAQIDRPVHIWQGLDDRMVPDPINRAVADHMPGAIWHPVEGAGHFVAIGCADEIFGIAARELGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTR7</accession>
    <name>A0A132PTR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844503.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25705">
        <property type="protein sequence ID" value="KWX25705"/>
        <property type="gene ID" value="AFM11_04455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2767"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="61" mass="6467" checksum="A19AA57F2738384F" modified="2016-06-08" version="1">MADRRLAFAGLAFGVLALVAGSLQLWAFVDTDRPRHVVVAVFALSVGGSVVVAAARSLWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTV4</accession>
    <name>A0A132PTV4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="10" type="ORF">AFM11_00255</name>
        <name evidence="11" type="ORF">AWC31_33365</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842152.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33365"/>
    <dbReference type="EnsemblBacteria" id="KWX25768">
        <property type="protein sequence ID" value="KWX25768"/>
        <property type="gene ID" value="AFM11_00255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11579">
        <property type="protein sequence ID" value="ORX11579"/>
        <property type="gene ID" value="AWC31_33365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.52"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX11579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="100" mass="10916" checksum="91724A7FF9F47C38" modified="2016-06-08" version="1">MATITDPRDIILAPVISEKSYGLIEDNVYTFVVHPDSNKTQIKIAIEKIFGVKVDSVNTANRQGKRKRTRTGFGTRKSTKRAIVTLAAGSKPIDLFGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUA5</accession>
    <name>A0A132PUA5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844785.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25632">
        <property type="protein sequence ID" value="KWX25632"/>
        <property type="gene ID" value="AFM11_05245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2934"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="77" mass="8746" checksum="E3AF4DF784AA3666" modified="2016-06-08" version="1">MTETVTVDFTNPDALFLPRHVAEHRHMSENALAQERFAGAGPRYLKLGRRVYYRAGDLKAWLDEHTVTPGAPVPQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUD5</accession>
    <name>A0A132PUD5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00905</name>
        <name evidence="3" type="ORF">AWC31_33940</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842485.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33940"/>
    <dbReference type="EnsemblBacteria" id="KWX25884">
        <property type="protein sequence ID" value="KWX25884"/>
        <property type="gene ID" value="AFM11_00905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11684">
        <property type="protein sequence ID" value="ORX11684"/>
        <property type="gene ID" value="AWC31_33940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.187"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="98" mass="10802" checksum="817A11DFA4873B1F" modified="2016-06-08" version="1">MNQVLSYDFGEIEYSVRQEIHTTSSRLNAAFDDLRAQIAPLQQVWTREAAAAYQVEQARWNQAAAALNEILFNLGNAVRDGSDDVAATDRSAASAWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUE4</accession>
    <name>A0A132PUE4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FhuF_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842519.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34000"/>
    <dbReference type="EnsemblBacteria" id="KWX25894">
        <property type="protein sequence ID" value="KWX25894"/>
        <property type="gene ID" value="AFM11_00970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.200"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF_C" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="236" mass="24787" checksum="E70AAD7E6A01B308" modified="2016-06-08" version="1">MDDTAALLREVAELGEFFALPVADDGGWLPISTLLTDTAMRDYTRRTQAAIASSMGVAESAVPLKAAASSLHLSIAARLLSPVVGAAVCLAAVPRLTTETVKWQRDSSHRPALAMTRADWVRVTDPHQAARAIAETVITDVFAPLNDTMRSAAALSPQVLWGNVASAANGAVTVLAQTQAAAERRGRALVAALIATAPLLDAAEFAAGQFRRRNCCLFYQVPGGGYCGDCVLAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUT6</accession>
    <name>A0A132PUT6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_01945</name>
        <name evidence="6" type="ORF">AWC31_34725</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843000.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34725"/>
    <dbReference type="EnsemblBacteria" id="KWX26034">
        <property type="protein sequence ID" value="KWX26034"/>
        <property type="gene ID" value="AFM11_01945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11813">
        <property type="protein sequence ID" value="ORX11813"/>
        <property type="gene ID" value="AWC31_34725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.399"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="171" mass="18779" checksum="54E506DF6FEF99E7" modified="2016-06-08" version="1">MTNPDGHELAPVPLRVNHSRPGAFQLDELSKAIIEKLQQDGRRSYAGIGKAVGLSEAAVRQRVQRMVDAGVMQIVAVTDPMQLGFARQAMIGIRCTGDTTKLAEKLAHIEQVDYVVLTAGSFDAICEVVCEDDDSLLELLNTEIRALPGVISTETLVYLKLVKQQYNWGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV26</accession>
    <name>A0A132PV26_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843422.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35525"/>
    <dbReference type="EnsemblBacteria" id="KWX26165">
        <property type="protein sequence ID" value="KWX26165"/>
        <property type="gene ID" value="AFM11_02750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.566"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="211" mass="21904" checksum="3A7D456B72D5CDD2" modified="2016-06-08" version="1">MTRVVLGSASSGRLGVLRQAGIDPLVIVSDVDEDAIIAARRDAPPADVVTALATAKADAVVARVPDSIAADTVVVGCDSMLLLDGRLCGKPGSPEAAQRQWQTMAGRSGDLYTGHCVIRLRDGDVVGRTAESASTTVHFSDPTPGDLTAYVESGEPLWVAGAFTLDGLGGWFVDGIEGDPSNVIGLSLPLLRRLLNELGLSIADLWSANRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVC7</accession>
    <name>A0A132PVC7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_01765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34515"/>
    <dbReference type="EnsemblBacteria" id="KWX26265">
        <property type="protein sequence ID" value="KWX26265"/>
        <property type="gene ID" value="AFM11_01765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.363"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="330"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="514"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="676"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="757"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="858"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="866"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX26265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="931" mass="98213" checksum="11890DBED8E122BF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAR5</accession>
    <name>A0A132PAR5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000059">
        <property type="protein sequence ID" value="KWX19419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19419">
        <property type="protein sequence ID" value="KWX19419"/>
        <property type="gene ID" value="AFM11_35965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6272"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="163" mass="18428" checksum="050C0D078BF5B8FD" modified="2016-06-08" version="1">MQPSSSLTEAQRGAAVALFEQGRGDSATARYLGVSRWPVRVLHRRWVLHGRKALVAKPTRTAYSFEFKLDVVCKVIDEGAAAQQVAQEYGLSSATLVQTWVRAYRRLGEDGLKPKPKGRQPKDADSSSQELTDLQRLEQENVRLRAENAYLKKLRALRAHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB78</accession>
    <name>A0A132PB78_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859751.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19554">
        <property type="protein sequence ID" value="KWX19554"/>
        <property type="gene ID" value="AFM11_35280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5786"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453136" evidence="1">
        <location>
            <begin position="36"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="176" mass="18355" checksum="FA3D02ADDB2E5F10" modified="2016-06-08" version="1">MTMGDRRPHRTGVAVAATALVLAAGAAVTSGLALARPLTPAQHTVNVVEPPPATYSNTDIVAAKNATCSAWDQAARTITSAGKQRASIAATTGRSSPETDEARTVEKRTTTTQISFLRTQLSPATPSDISKPVSDWMASQIDAMHGVNVRDWDASNAAITRGNDLVDVIDAKCGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBQ0</accession>
    <name>A0A132PBQ0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4Fe-4S Wbl-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859204.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19724">
        <property type="protein sequence ID" value="KWX19724"/>
        <property type="gene ID" value="AFM11_34340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5212"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="89" mass="9171" checksum="72E7FF29D5DF22A6" modified="2016-06-08" version="1">MAELLAGIPNLPGACCKGRSDLFEATIAGRDGPASKTELENSRAAALRLCAACPALAPCRAWLNGLRPTRRPLGVVAGEVVNASGQVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBS0</accession>
    <name>A0A132PBS0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_35850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000052">
        <property type="protein sequence ID" value="KWX19432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859993.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22470"/>
    <dbReference type="EnsemblBacteria" id="KWX19432">
        <property type="protein sequence ID" value="KWX19432"/>
        <property type="gene ID" value="AFM11_35850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6249"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX19432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="137" mass="15197" checksum="E13BA3A36A7D1D6B" modified="2016-06-08" version="1">MADTAPTTPRLSLTTQAFRFILTGGLSAIVDFGLYVALLATGMHVNIAKTLSFIAGTTTAYLINRRWTFQAPPSKARFIAVCVLYALTYAVQVGINYVFYMAWDEKPWRVPVAFVIAQGTATVINFVVQRAVIFRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBS3</accession>
    <name>A0A132PBS3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_34015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859021.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02465"/>
    <dbReference type="EnsemblBacteria" id="KWX19770">
        <property type="protein sequence ID" value="KWX19770"/>
        <property type="gene ID" value="AFM11_34015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5140"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="477" mass="49683" checksum="3C1EF11A46F44C4D" modified="2016-06-08" version="1">MSEDLQTGTAAGDAGLRRGVMGGGELAAQAIANIAPSAVIAFTAAAIYTTASNGTWISFALATVVILSVGYCISQFAKRRSSAGSLYSYAATTLGPFGAYLTGVSLLIGCFGIAAGSLSGSVAYTATLLNQLGIPVQGLVAQIVLAIVLGALATLFTIRGIRLSARVSLVLELISIFIIALLLVVTLVHLGSDAFDADQFDLTGAQPSGIAVGMVLAILGFVGFSSSDALAREAKDPYRAVPRAIMWSAAGVGVLYIFAAYTQVAALGPALGESAQPLDDIATLVGMPTWFNPILNFGIAASFFAVVVAPMNVIGRILYVMGKEGVVPSAIGRTHPTHLTPHRALLTVSPFVIAVSIVMYLNGVDPMNVVTWVDTYGTYGYMVAYAAAALAAVKFLRSIDARVPLVWPAAAVAIASMAYVFYANVYPVPAYPLNVIPWLFIATVAVALMWYLILSRRSPQVISKIGTSEVETLEGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBZ3</accession>
    <name>A0A132PBZ3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858933.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19849">
        <property type="protein sequence ID" value="KWX19849"/>
        <property type="gene ID" value="AFM11_33640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5062"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="117" mass="13459" checksum="F5ECC72CB6E286FA" modified="2016-06-08" version="1">MVELEIYPERLDEFVAGIGANSRASRSEKGCLRFDVQHDLQIPVKFHFYEIYTDEDAFRIHHRQAPHYAEWQNVVARCVVPGTQHNTYAEPLFPQDIPEAAQPDRAQGLLPNTVGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC24</accession>
    <name>A0A132PC24_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19885">
        <property type="protein sequence ID" value="KWX19885"/>
        <property type="gene ID" value="AFM11_33440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5019"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="262" mass="29519" checksum="FAFD0CFE6BF3BCDE" modified="2016-06-08" version="1">MDRDEYLAIQRANEAHAERLRNRPRPSFAELGSRMANASELMPVKAKRHDPRQKWETIDALDHLINSPVSATPKLATEHQVNQVLASMIAGEHLPVAEGEVWVGIVAKALRDYHSWFESDPERAAFGEGIGSRFELDNLPQTHDNTDKYGEVLVPWNPQRELGVAVVVSTSRPGHRWLLRGITTIQSVIGEVQDDQHCDLGYGRCTRSTKPSAFNAFPFHHGDLVVIAHVCRECWQQWIDVHIPEPPEEIITENDVATPPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC44</accession>
    <name>A0A132PC44_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_33545</name>
        <name evidence="6" type="ORF">AWC31_02205</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858756.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02205"/>
    <dbReference type="EnsemblBacteria" id="KWX19905">
        <property type="protein sequence ID" value="KWX19905"/>
        <property type="gene ID" value="AFM11_33545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13354">
        <property type="protein sequence ID" value="ORX13354"/>
        <property type="gene ID" value="AWC31_02205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5042"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX13354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="214" mass="23231" checksum="E1174A56366D8755" modified="2016-06-08" version="1">MRVVIAEDSALLRAGIERILADAGHEVVAGVPDATNLLRLVNEHRPDLAILDVRMPPTFTDEGIRAAALLRSQNPESPVLVLSHYVEERYAADLIASDTKGFGYLLKDRVADVPAFLDAVEVVGGGGTVLDPEVVSQILVRSHRRSALDQLTPREQDVLQLMAEGKTNSAIATALHISVGSAEKHIASIFTKLDLAPDESENRRVLAVLRYLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCB4</accession>
    <name>A0A132PCB4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858530.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17065"/>
    <dbReference type="EnsemblBacteria" id="KWX19944">
        <property type="protein sequence ID" value="KWX19944"/>
        <property type="gene ID" value="AFM11_33160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4964"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="305" mass="30953" checksum="6B98731C443BCEE5" modified="2016-06-08" version="1">MGLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPAGGGSAAQGVVDEIVAAGGEAVTSGANVADWAQAEGLIQTAVDAFGGLDVLVNNAGIVRDRMFANTSEEEFDAVTAVHLKGHFATMKHAAAYWRAQVKSGSTGPDELQARIINTSSGAGLQGSVGQANYSAAKAGIAALTLVAAAEMGRYGVTVNAIAPSARTRMTETVFADMMATQDQDFDAMAPENVSPLVVWLGSVESKDVTGKVFEVEGGKIRVAEGWAHGPEIDKGARWDPAELGPVVSDLLGKARPAVPVYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCT7</accession>
    <name>A0A132PCT7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857805.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20155">
        <property type="protein sequence ID" value="KWX20155"/>
        <property type="gene ID" value="AFM11_31940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4714"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="157" mass="16294" checksum="E28F152684449FE5" modified="2016-06-08" version="1">MDLTTLARELLEPLPAHRTVGVEVLRAADGEAEISSRTSKQLTNVIGSLHSSGLIALIDAAGLAAIIAGAPNKNAMAGILPLGRTASVEFLAPARGRLLATAALDDEARHALEPLWAGASDRARFSTAAQIMDSSGTVVSRGSFDWSVRRVPVGDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCW3</accession>
    <name>A0A132PCW3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857874.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31830"/>
    <dbReference type="EnsemblBacteria" id="KWX20178">
        <property type="protein sequence ID" value="KWX20178"/>
        <property type="gene ID" value="AFM11_32065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4739"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="66" mass="6850" checksum="5D8E169B8062FF01" modified="2016-06-08" version="1">MPRALVVVFGIVGVFIALCGLLFALQGFGVVGGSPMSNTTTWSILGPIILVVGAAIAYAAWRSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCY0</accession>
    <name>A0A132PCY0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20201">
        <property type="protein sequence ID" value="KWX20201"/>
        <property type="gene ID" value="AFM11_31760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4679"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452979" evidence="1">
        <location>
            <begin position="36"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="44"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="222" mass="23780" checksum="753224A39E6C8CAB" modified="2016-06-08" version="1">MKVSLSGAVRPVQIAMMGVVLATVLVWGPSGRAYAAPAAQAGDVISIGDPAAPGQVELYLDPLCPYSGKMIQEQGTEIRRRVEAGKLHITLRFVNFLEKYSASGTYDSRAIYAAYIVADHSRSSDVTWQFIQQIYAADQQPKEGGATDLSNDQLVDLARRVGAPPTAQAMIGLGLPMPYDARGIAANNLALLRTFPEAGVPLAVIDGRPVDGNSDWLDELPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCZ5</accession>
    <name>A0A132PCZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858164.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19735"/>
    <dbReference type="EnsemblBacteria" id="KWX20097">
        <property type="protein sequence ID" value="KWX20097"/>
        <property type="gene ID" value="AFM11_32600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4848"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="17"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="666" mass="70939" checksum="3B8E9AADE45D5BB8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD01</accession>
    <name>A0A132PD01_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32160</name>
        <name evidence="4" type="ORF">AWC31_31690</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31690"/>
    <dbReference type="EnsemblBacteria" id="KWX20213">
        <property type="protein sequence ID" value="KWX20213"/>
        <property type="gene ID" value="AFM11_32160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12706">
        <property type="protein sequence ID" value="ORX12706"/>
        <property type="gene ID" value="AWC31_31690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4759"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_3" evidence="2">
        <location>
            <begin position="34"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX12706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="110" mass="11643" checksum="4FBF9B883B0A7CBD" modified="2016-06-08" version="1">MRHAPAEGTDLPAAQPKPTSKSNQMESSLDLWGDGETSVGIWECGPGEFTADRSKATEVCHIVSGHGTVTGEDGSSADIGPGSLLVLPRGWRGTWVVHETIRKSFVLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD02</accession>
    <name>A0A132PD02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Butyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_31235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857405.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25385"/>
    <dbReference type="EnsemblBacteria" id="KWX20218">
        <property type="protein sequence ID" value="KWX20218"/>
        <property type="gene ID" value="AFM11_31235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4152"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="108"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="225"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="334"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX20218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="465" mass="49100" checksum="59DEC2121740624C" modified="2016-06-08" version="1">MTNTLPSKNGSATRPIRSGQQSAVGLQKHKRTATDIGLALITPIVGQEFLDRYGLRDPLNRGLKYGVKQVFSVAGASTRQFKKIQGLGKEPTRLKAGSADLFDLTPDDDQKMIVETVSEFAEEILRPAAHDADDAAAYPADLIAKAAELGITAVNVPEDFDGIAEHRSTVTNALVAEALAYGDMGLALPILAPGGVASALTHWGSADQQATYLKEFAGENVPQACVAIAEPHALFDPTALKTTAVRTPSGYRLSGVKSLVPAAADAELFIVAAQLNGKPALFVVEASSAGLTVKADPSMGIRAAALGQVELDNVAVPLSARLGEDGASDQDYSEAIALSRLGWAALAVGTSHAVLDYVIPYIKERQAFGEPIAHRQSVAFMTANIAIELDGLRLITWRGAARAEQGLPFAREAALARKLGTDKGMQIGLDGVQLLGGHGYTKEHPVERWYRDLRAIGVAEGVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD04</accession>
    <name>A0A132PD04_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyamine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_32175</name>
        <name evidence="7" type="ORF">AWC31_31675</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857929.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31675"/>
    <dbReference type="EnsemblBacteria" id="KWX20196">
        <property type="protein sequence ID" value="KWX20196"/>
        <property type="gene ID" value="AFM11_32175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12527">
        <property type="protein sequence ID" value="ORX12527"/>
        <property type="gene ID" value="AWC31_31675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4762"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX12527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="266" mass="28669" checksum="02B80E2941955D9B" modified="2016-06-08" version="1">MNSRLNTVWRTLLLLFCGIVALWLVAPSLVVIPLSFTDRPTFTFPPEGWSTQWYANFFSDPSWMAALQASIQVGVLVAIVATVCGTAAALALSRTRFFGQQGLRALLLAPMLVPVIVIAIGLYALFLRLNLLGTTFGFVVAHSVLALPFVIIPVMASLQGFDRRLEDAAAICGAGRWTAFRTVTLPLVAPGVLSGAVFAFATSFDEVVLSLFIQSPYLQTLPVRMYSSVTRDTDPTIAAAATLILALTTVVTVLASIYATRRRNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDH6</accession>
    <name>A0A132PDH6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857279.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26800"/>
    <dbReference type="EnsemblBacteria" id="KWX20393">
        <property type="protein sequence ID" value="KWX20393"/>
        <property type="gene ID" value="AFM11_31090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4122"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038750">
        <property type="entry name" value="YczE/YyaS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40078">
        <property type="entry name" value="PTHR40078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="24371" checksum="672AEC2CEF32F19C" modified="2016-06-08" version="1">MRAAVTRGTLLITGLIGYGFSMGMMVRAGLGLDPWDVFHQGLTRHTPMTIGIASAVVGVVVLFAWIPLRNRPGIGTVANVIVIAVTVDATLALLPAPSAMPARIAMMVGAVVLNAVATVLYIGAGLGPGPRDGLMTGLVARTGLSVRLVRTAIEATVLVIGWLLGGTVGVGTVVYAFGIGPLVQLFLRLMPRRILFHDFSGGDRARRERVTTMSECPQPEKTQPTVSTTKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDM9</accession>
    <name>A0A132PDM9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20441">
        <property type="protein sequence ID" value="KWX20441"/>
        <property type="gene ID" value="AFM11_30110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="59" mass="5820" checksum="6E6BAE421FBD8FEB" modified="2016-06-08" version="1">MERCEHLGEVLGESIGRVGVRALAVGASAVAAMVVEEDAKSGALHQTLCGAMPGGGAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDX1</accession>
    <name>A0A132PDX1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857012.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20520">
        <property type="protein sequence ID" value="KWX20520"/>
        <property type="gene ID" value="AFM11_30090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3912"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="22674" checksum="AB3138A3FFA927C4" modified="2016-06-08" version="1">MTSPEIRQIVRNVYDQHLPLPQEWTASQREQFMEAEASRISRQVADLAAQMGEQAVQHWQNHHGQPPDYLTKVGLLNNAHSQAMETVLSTELYEQIPPTEDDNQAATETSPDRSQVPWDQRWTNTQYRSDPSEQIEALVATIWSAPDFSAVFRIKAGYLLAARVEDQLRLPTHRHDPLAATLADLVYRDLRHDGLPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDX5</accession>
    <name>A0A132PDX5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857056.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00610"/>
    <dbReference type="EnsemblBacteria" id="KWX20538">
        <property type="protein sequence ID" value="KWX20538"/>
        <property type="gene ID" value="AFM11_30620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4025"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="82"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="214" mass="21981" checksum="5FE4A6B25EAE68DD" modified="2016-06-08" version="1">MIVSAVPAAAQPDQWDPTLPKVVSSGAPGDPVAIANASLQASQFATQATLDLGRRFLSSLGIGGDAGPPTAAAGRLGRVNGRQAIEYVIRRGASQAGVPYSWGGGKPTGPTRGVDSGANTVGFDCSGFTQFAFAGVGVLIPKFSGDQYNTGRKIPPSQAKRGDLIFYGPGGTQHVAIYLGNGRVLESASSYGKVSINPLRTAGMSPYLTRIIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE01</accession>
    <name>A0A132PE01_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20553">
        <property type="protein sequence ID" value="KWX20553"/>
        <property type="gene ID" value="AFM11_29560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3803"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="106" mass="11574" checksum="024DCE2C3A07715C" modified="2016-06-08" version="1">MADTPEGEDQRRFSGRAAILSLGGQVFDLCEHSSNAGERFDPVRTGLDHFALEAESLADLQAWASWLDTSGVARSEIRKVAGDLGTMFDFVDPDGIQVEFVHFDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE49</accession>
    <name>A0A132PE49_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_29625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856472.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20564">
        <property type="protein sequence ID" value="KWX20564"/>
        <property type="gene ID" value="AFM11_29625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3817"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="192" mass="20931" checksum="29F5CF6F3EE4233D" modified="2016-06-08" version="1">MADIGTRDRILEATAELYRRQGMAATGLKQISRASRAPFGSIYHHFPGGKESISVEVIRCEGVRYGELVSAQLAQTDPADGIPQLFENAGRLLESQDYSEACSIETIALEVASTNERLRVEAAAVFESWLVRLADWFMQLELTAEQSRRLAAITLTALEGAFVLCRTLRSTEPMIDAGIGVQAAVDAVRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEE5</accession>
    <name>A0A132PEE5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040150.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20700">
        <property type="protein sequence ID" value="KWX20700"/>
        <property type="gene ID" value="AFM11_29220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3729"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="121"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="488" mass="51926" checksum="7C0157ED5E5B3F68" modified="2016-06-08" version="1">MYLHKRVKVQLAILTVLAVVVISLMTLHVMKLPAKLFGVGRYTVTMELPQTGGLYATGNVTYRGTEVGRVQSVHLTDTGVAAVLSLKSGIDIPSDVKAEVHSQSAIGEQYVDLLPRSDTAPPLKNGDVIPLRDASVPPDINKLLTAVNTGLRAIPRDNLNTAVDEAYTAVGGLGPELARLVRASTRLSIDARANLDSLTSLIDQSQPVLDSQTDTSDAIQAWAANLATVTAELQTHDNAVAGIIDHGGPAAGEVRQLFERFQPTLPILLANLVSVGQVALTYRNDLEQLLVLLPQAAAIRGGSVVANANTKQDYRGEWISFNLNINLPPACTTGFLPTQQRRPPSFEDSPERPAGDVYCRVPQDSPFNVRGARNIPCETVPGKRAPTVRMCESDEQYVPLNDGFNWKGDPNATLSGQDIPQGAPGSPPTGAPPPAAVSPPPPPVAAAQYDPATGTYIGPDGQQYTQSDLAQTGPKEKTWQTMLTPPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEX6</accession>
    <name>A0A132PEX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855635.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10170"/>
    <dbReference type="EnsemblBacteria" id="KWX20873">
        <property type="protein sequence ID" value="KWX20873"/>
        <property type="gene ID" value="AFM11_27635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3401"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="171" mass="19044" checksum="D2C5CAD5B24E7B56" modified="2016-06-08" version="1">MTTNVITVGTERAIIESMLDRNRAALIETARGLSEVDARRRLVASLTTPISLLKHAAAAERIWFQRFWAGLDESECDGYSRRDEGTFAVADNESLADVIAEFERASERSRSIAARFDLDDTKDNPREGTVSMRWTLLAMIEEFARHAGHGDILREQIEHTAPPTAEVTIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFB2</accession>
    <name>A0A132PFB2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855228.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06790"/>
    <dbReference type="EnsemblBacteria" id="KWX21025">
        <property type="protein sequence ID" value="KWX21025"/>
        <property type="gene ID" value="AFM11_26940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3262"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="191" mass="20572" checksum="4968E57FF6AAEE98" modified="2016-06-08" version="1">MVSISNGESLGDRILDAAASCVLAFGIDRVTLAEIARRAGVSRPTVYRRFPDTRSILAALLTARIVRVLDDVETTEAGREALVERIVTVAQRLRHDDVIMAVLHTAPDLAMVYIAERLGTSQQILIDAVAGELKLAQEEGSVRAGDPRQLATMCLLITQSAIQSGQMVEPILDADALATELAHSLNGYLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFE3</accession>
    <name>A0A132PFE3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28040</name>
        <name evidence="4" type="ORF">AWC31_10560</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX09063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856016.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10560"/>
    <dbReference type="EnsemblBacteria" id="KWX20994">
        <property type="protein sequence ID" value="KWX20994"/>
        <property type="gene ID" value="AFM11_28040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09063">
        <property type="protein sequence ID" value="ORX09063"/>
        <property type="gene ID" value="AWC31_10560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3483"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="143" mass="15469" checksum="67619390B3AD2C85" modified="2016-06-08" version="1">MTGLARRFWIPLLIMVVVVVGAFTVMRVRTFFGAGDGSGISSAKVDDTKPFDPKVVVYEIYGVPGATADINYLDLDAQPQRIDGVTLPWSLRLESTAPSVFPNIVAQGNGDTITCRITVDDELKDERTSNGVNAQTFCLVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFF4</accession>
    <name>A0A132PFF4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fructose-bisphosphate aldolase class 1</fullName>
            <ecNumber evidence="4">4.1.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Fructose-bisphosphate aldolase class I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_28080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855838.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10625"/>
    <dbReference type="EnsemblBacteria" id="KWX20937">
        <property type="protein sequence ID" value="KWX20937"/>
        <property type="gene ID" value="AFM11_28080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3491"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00949">
        <property type="entry name" value="FBP_aldolase_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023014">
        <property type="entry name" value="FBA_I_Gram+-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="PTHR11627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="32075" checksum="33288184C286A134" modified="2016-06-08" version="1">MTNQVNQQQADKMTSGKGFVAALDQSGGSTPKALRLYGVEESAYSSEDEMFDLIHQMRSRIITSPAFTGERVLAAILFEQTMDRSIEGKPSATFLWEDKGVVPLLKIDKGLAEAADGVQLMKPMPALDDLLARGVKNGIFGTKERSVIGAANPTGVAAAVAQQFEVAKQVLSHGLIPIIEPEVTISISDKAEAEDLLKAEIAKNLDALPDGQQVMLKLTLPTVANHYKSLVDHPKVMRVVALSGGYSRDEANALLAQNSGVIASFSRALTEGLSAQQSDDEFNSTLDKSIQSIYDASIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFN5</accession>
    <name>A0A132PFN5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_27165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855567.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07015"/>
    <dbReference type="EnsemblBacteria" id="KWX21141">
        <property type="protein sequence ID" value="KWX21141"/>
        <property type="gene ID" value="AFM11_27165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3308"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="9">
        <location>
            <begin position="210"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="3">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604550-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="323" mass="32357" checksum="CA5CFDCECCD8EED4" modified="2016-06-08" version="1">MLTTAGPAGAEPQNARLVVITTGGTIATSTDPSGVRRPTVGGAELAAGLDVEVVDLMKKDSSQLTPADWDAIGTAVKNAVANGADGVVITHGTDTMEDTAMWLATTYQGSAPVVLTGAQRSSDAPDADGPTNLRDSLTVAASPAARDQGVLIAFAGNVFQALGTRKMNTADLAAFGGTAPVGTVGDNVFTLNQPARKPFIAEVSAGAAPRVDIVAAYPGDGPGPIDAAVAAGARGIVLEALGSGNAGDGVVDAVRRHAPAGVAFAISTRVPNGPVEAEYGPGDDMVKAGAVMVPNLRPSQARVLMMAALAAGRPVNDVFTRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG43</accession>
    <name>A0A132PG43_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exported repetitive protein Erp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855064.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22625"/>
    <dbReference type="EnsemblBacteria" id="KWX21244">
        <property type="protein sequence ID" value="KWX21244"/>
        <property type="gene ID" value="AFM11_26710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3213"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008164">
        <property type="entry name" value="XGLTT_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01744">
        <property type="entry name" value="GLTT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453057" evidence="2">
        <location>
            <begin position="30"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="29797" checksum="F1BBC8FCDECF8B1D" modified="2016-06-08" version="1">MPNRRRRKASTAMSAVAALAVASPVALVAVTQLSPTPQHREFTQAALVTDLPGELMSALSQGLSQFGINLPPMPTGMLTGSSPMPSLASPTLTSPGLASPGLTSPGLTSPGLTTPGLTSPGLTTPGLTTPGLTDPALATPGLTSPDGALPSTPSLTDPGLTNPSLTNPALTNPALTSPAGAVPGGLATPDLGTPGLTTPALGTDPSLTPISNAAGLPAPGEVPISAPIGLDPGLGATYPILGDPSLGAMPAASTGGGGLFGDLSSAAEQLGAGQAIDLLKGMVIPAITSAMKSGVPAAPPVPPAPVPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGI1</accession>
    <name>A0A132PGI1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="14">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alpha-IPM isomerase</fullName>
            <shortName evidence="14">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">leuC</name>
        <name evidence="17" type="ORF">AFM11_24965</name>
        <name evidence="18" type="ORF">AWC31_27220</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="14"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854088.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27220"/>
    <dbReference type="EnsemblBacteria" id="KWX21468">
        <property type="protein sequence ID" value="KWX21468"/>
        <property type="gene ID" value="AFM11_24965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14846">
        <property type="protein sequence ID" value="ORX14846"/>
        <property type="gene ID" value="AWC31_27220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2354"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12 14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="16">
        <location>
            <begin position="16"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KWX21468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX14846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="484" mass="51406" checksum="3B50A39E16AE330D" modified="2016-06-08" version="1">MDQPTKTSAKPRTLAEKVWDDHVVALGEGEGASKEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCEEFGIRLHPMGDTEQGIVHIIGPQLGLTQPGMTIVCGDSHTSTHGAFGSIAMGIGTSEVEHVMATQTLPLKPFKTMAVNVDGVLPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIEALSMEGRMTVCNMSIEAGARAGMVAPDETTFEFLKGRPHAPKGADWDAAVEAWSQLRTDEGAEFDTEIYLDAAELTPFVTWGTNPGQGVPLSASVPDPELMGDDAARQAAEKALTYMDLRPGTAMRDIAVDTVFVGSCTNGRIEDLRVVADVLKGRTVADGVRMLVVPGSMRVRAQAESEGLDRIFIDAGAEWRQAGCSMCLGMNPDQLSPGQRCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGKLASPADLPAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGV0</accession>
    <name>A0A132PGV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VII secretion protein EsxS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25455</name>
        <name evidence="1" type="ORF">AFM11_33030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04050"/>
    <dbReference type="EnsemblBacteria" id="KWX20030">
        <property type="protein sequence ID" value="KWX20030"/>
        <property type="gene ID" value="AFM11_33030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21551">
        <property type="protein sequence ID" value="KWX21551"/>
        <property type="gene ID" value="AFM11_25455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2454"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="38" mass="3920" checksum="6CC984A31E5162BC" modified="2016-06-08" version="1" fragment="single">MSMLDAHIPQLVASEAAFGAKAALMRSTIAQAEQAAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGW2</accession>
    <name>A0A132PGW2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25430</name>
        <name evidence="3" type="ORF">AWC31_27790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX15124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854365.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27790"/>
    <dbReference type="EnsemblBacteria" id="KWX21566">
        <property type="protein sequence ID" value="KWX21566"/>
        <property type="gene ID" value="AFM11_25430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15124">
        <property type="protein sequence ID" value="ORX15124"/>
        <property type="gene ID" value="AWC31_27790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2449"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="289" mass="31360" checksum="33B6FF9FC5161BA0" modified="2016-06-08" version="1">MTRSSIDLPSGTVSYLTWEPDDPTLSVVLLHGGGVDNASLSWGSTAPRLAEAGYRVIAPDHPGFGHSPPARLPVTQERLVTYVAELTEALELDRYAIGGLSLGGGMAIGHVLDRPDRVTGAMLLGSYGIMPRLSDGRWSALRQLVTWVALRSGLLGATTRWVGGNRAAMMRSMQALIKDPAQLTGELMDEIMAAARQPGGFEAFEQWQRDQVRWNRQRTDYTLQLASFPCPALIIHGERDAGVPVTHARTAARLIPNAHLKIVAGAGHWVQRDQPDIVAEAMIGFLDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGZ9</accession>
    <name>A0A132PGZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper resistance protein CopD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_26545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855143.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22790"/>
    <dbReference type="EnsemblBacteria" id="KWX21272">
        <property type="protein sequence ID" value="KWX21272"/>
        <property type="gene ID" value="AFM11_26545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3179"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453028" evidence="7">
        <location>
            <begin position="22"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="8">
        <location>
            <begin position="202"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="306" mass="30757" checksum="525BD364A86FE52A" modified="2016-06-08" version="1">MTWRAAAGAALVLAAASAAAAALSYPQNQLAGALVRTVADCAAVVTVGLAAVPMLESARYRAELARTAARPLAFSSAVWLLAELVRLIVVAAQAAAVPVQRVGVHTVGEFALHTTVGRSGLVAIVAALAVCVTTLLAPRTAAAIVATIGTAAAGVAARTLAGHLAESPVGGLAVAVHALAAAVWCGVLAALVLTVTHRGQWARVLPRFSQLSLGSVAVLLLAGVLGAVIRLQAPAELWTTGYGRLLAAKVVVTVGLLVLAWRNRAGWLPAARAHRTSASLSTNRSLAELAVMAVAVTFAAALAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH07</accession>
    <name>A0A132PH07_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853614.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21625">
        <property type="protein sequence ID" value="KWX21625"/>
        <property type="gene ID" value="AFM11_24150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2189"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="152" mass="17200" checksum="3566079BF27D82E7" modified="2016-06-08" version="1">MNTVLYFSANGAVYETRAYTTADIDKLVEDQGLQCLTSADRQFDFWFSPATRGCQHRANRRATELLLATTTFTAKSVPLLRGCVVVATHDADGDLDGLSWQQLDLLVRKSQSLTKHDARILDRRIARDARRDRRHTATRQGAVRLKFAPQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH67</accession>
    <name>A0A132PH67_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_25815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854537.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21342">
        <property type="protein sequence ID" value="KWX21342"/>
        <property type="gene ID" value="AFM11_25815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3027"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="739" mass="78330" checksum="C3621BD25B957DF1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH76</accession>
    <name>A0A132PH76_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2'-hydroxyisoflavone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853758.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23650"/>
    <dbReference type="EnsemblBacteria" id="KWX21671">
        <property type="protein sequence ID" value="KWX21671"/>
        <property type="gene ID" value="AFM11_24470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2255"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="309" mass="33378" checksum="8E7B19A6AA0B1552" modified="2016-06-08" version="1">MPPTTARPAILVIGTGELGASVLAALTRHVGEHPGAATISVLLRPPAPDTGGQRDSRSKELTAMGIAIEHADVATASAAELAAIMGGYDTVISCIGFAAGSGTQLKLARAALTAGVPRYFPWQFGVDYDEIGRGSAQPLFDEQLDVRDLLRDQHTTEWVIVSTGMFTSFLFEPAFGVVDLAANTVHALGSWDNEVTLTTPEDIGVLTADIVFAQPRIRDTVVYLAGDTISYRELADIVDRVRGTTVTREEWTTEYLADQLRRDPEDTMRKYRAVFARSNGVAWPKAQSYNASHGIATTTAEEWARRNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHG4</accession>
    <name>A0A132PHG4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853164.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21798">
        <property type="protein sequence ID" value="KWX21798"/>
        <property type="gene ID" value="AFM11_23395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2034"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="78" mass="7418" checksum="04F62A3F6B61D571" modified="2016-06-08" version="1">MTKFARLRINTIAAIFGGGAVVSMGVIAAAVGGAQAGPPVVASGGSMTIGETTTVTYTGTVAPVVAKPAVKAPPYGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIE8</accession>
    <name>A0A132PIE8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852407.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04510"/>
    <dbReference type="EnsemblBacteria" id="KWX22116">
        <property type="protein sequence ID" value="KWX22116"/>
        <property type="gene ID" value="AFM11_21705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1689"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="26714" checksum="3E125544CF2E36EC" modified="2016-06-08" version="1">MDLTQRLAGKVAVITGGASGIGLATGRRLHAEGATIVVGDIDPTTGKAAADELDGLFVPVDVSDQAAVDNLFDTAASTFGSVDIAFNNAGISPPEDDLIENTELPAWERVQDINLKSVYLSCRAALRHMVPAGKGSIINTASFVAVMGSATSQISYTASKGGVLAMSRELGVQYARQGIRVNALCPGPVNTPLLQELFAKDPERAARRLVHIPLGRFAEPEELAAAVAFLASDDASFITGSTFLVDGGISSAYVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIF5</accession>
    <name>A0A132PIF5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21782">
        <property type="protein sequence ID" value="KWX21782"/>
        <property type="gene ID" value="AFM11_23290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="77" mass="8329" checksum="AFBAB96DCB24DD87" modified="2016-06-08" version="1">MATVARRTGVLYRPSRSQSGSNTAQIIALLEFSNPVNQFQIVLVVVENYCAAASRVKGDAIAGVIDPPRVNLLRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJA3</accession>
    <name>A0A132PJA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851857.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28640"/>
    <dbReference type="EnsemblBacteria" id="KWX22415">
        <property type="protein sequence ID" value="KWX22415"/>
        <property type="gene ID" value="AFM11_19875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1309"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="224" mass="23237" checksum="5E8C291F1EFCE114" modified="2016-06-08" version="1">MAEVLVTGGDTELGRVIAAGFRDAGHNVVIAGARRDDLEVAAKELDVESIVFDNTDAASLEAARAQFPHHLDTLVNVPAPLWEAKDPRTYTLADLAAAWRNNLDATVVSAALTVQIVGDHLRSGGSIINVLPDSPREGSAEAAVKAALSDWTAGQASYFGTRGITVNAVAAGRSAEPGYDGLGTTPPSVADEFARLAIFLSTSSARHITGQTLHVSRGALATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJI3</accession>
    <name>A0A132PJI3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851939.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11400"/>
    <dbReference type="EnsemblBacteria" id="KWX22496">
        <property type="protein sequence ID" value="KWX22496"/>
        <property type="gene ID" value="AFM11_20315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1396"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="24"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="435" mass="46373" checksum="7831B6D297048A4D" modified="2016-06-08" version="1">MHTPEVVPSPDTVAAETKPDRDRAVDVARLGALMVVMFGHCAMLLATIDSGGVRVGNILGELPALTPITWVLQVMPLFFLAGGAAGAYSWHRGNPWGAWLFTRAQRLCRPVFWYLAVWTVALVAVHATMGEESADALGRECVALLWFLGVYLVTLAFVPALTRLSTGRSAAALVAMLIAVSTVFDVLRFQWDSAAVATPNLIVVWLIPMVIGVAYARRLIQVRVAVAVAVSAFAAAVLLVVFGPYDVSLVVTGTERVSNVSPPTLLLALHCTWVSCLFVAAAGAIQRWARRPRVWYVVAVGNRGAMTIYLWHIPVIAVAAFSLHAIGLDAFDPHAPGFWGLLAMRAALFAVLMAMAFRLLSPLEHRPLPWWDGPVRVTGGRSIMAGALICLAGAALTLMAKNGLDGTVGWSALGGFVVAAGAARLSVGSAQRQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJM9</accession>
    <name>A0A132PJM9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_18670</name>
        <name evidence="8" type="ORF">AWC31_22425</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851485.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22425"/>
    <dbReference type="EnsemblBacteria" id="KWX22550">
        <property type="protein sequence ID" value="KWX22550"/>
        <property type="gene ID" value="AFM11_18670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15354">
        <property type="protein sequence ID" value="ORX15354"/>
        <property type="gene ID" value="AWC31_22425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1071"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="29"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX15354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="276" mass="31438" checksum="37804C8F81B10E30" modified="2016-06-08" version="1">MTFTDAAAQSRTFARARRDLVEGFGKRELWLHLGWQDIKQRYRRSVLGPFWITIATGATAVAMGVLYSKLFKLELAEHLPYVTLGLIVWNLINASILEGAEVFIANEGLIKQLPTPLSVHVYRLVWRQMILFGHNIIIFVVIAIIYPKPWKWTDLAVIPALGLIVLNCVWVSLCFGILATRYRDIGPLLASLVQLLFFMTPIIWNEATLQQQGAGSWAKIVELNPLLHYLDIVRAPLLGADQELHHWLVVLTLTVVGWILAAFAMRQYRARVPYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK56</accession>
    <name>A0A132PK56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851796.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22715">
        <property type="protein sequence ID" value="KWX22715"/>
        <property type="gene ID" value="AFM11_18790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1093"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="218" mass="23996" checksum="1CC6D5204CC7029A" modified="2016-06-08" version="1">MQRDGVGDAFECGLFLPARQTVQFPDILSGYTRSEALLPYLAEDDHRHVDEDRHLLDEEAMRLDAERFARDVARYHAVRRETSMLAMINTALPLGESVALTRGQDYLLSVARDERVRLGEPDMRDLSRAAAAMRDLVCAKLDALVVDSVTVAADGDTLVSGDGDELAVLGRLCPTCWYATRAALAQRAIDDQVYPVLGQGLLDPTSVAVLYTLALIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK85</accession>
    <name>A0A132PK85_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_19965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851875.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28550"/>
    <dbReference type="EnsemblBacteria" id="KWX22432">
        <property type="protein sequence ID" value="KWX22432"/>
        <property type="gene ID" value="AFM11_19965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1327"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453342" evidence="9">
        <location>
            <begin position="29"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="226"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="291"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX22432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="455" mass="48335" checksum="7EBC5EFED2DDDEB8" modified="2016-06-08" version="1">MSSNVVFSLLSILAVVLLTAGTAVFVAAEFSLTALERSTVEANARDGDRRDQLVRRAHRTLSFQLSGAQVGISITTLATGYLAEPVVGRLIQPGLDAIGIPANVTGGLSLFLAVLIATSLSMVFGELVPKNLAVARPVPTARAAAPFQLLFSMLFTPVIRLTNGTANWILRRLGIEPAEELRSARSAQELASLVRNSARSGSLDQTTALLVDRSLRFGERTAEELMTPRSKIEALNADDTVADLMTAAIDTGFSRFPIVEGDLDQTIGVVHVKQVFTVPLDERARTRLAGLAQPVATVPSTLDGDAVMTQIRANGLQTALVVDEYGGTAGMVTVEDLIEEIVGDVRDEHDDATPDVVPAGQGWQVSGLLRIDEVAAETGFRAPEGEYETIGGLVLQELGHIPETGEAVELTAFDPDSGADEPARWLATVVRMDGRRIDLLELTGLGNGDGGEHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKE8</accession>
    <name>A0A132PKE8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851732.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15520"/>
    <dbReference type="EnsemblBacteria" id="KWX22667">
        <property type="protein sequence ID" value="KWX22667"/>
        <property type="gene ID" value="AFM11_19435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1220"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="337" mass="35190" checksum="47CFBC6D57E1E7FC" modified="2016-06-08" version="1">MTSPQLPVIAVTMGDGAGVGPEVVVPALLDEYVLTRCNPVVIGDAKRLRQAAGILGIDVRINTVASPADAAPQPGVINVIDLDLLPADLEWGTLSAAAGNAAYEYIRVAAELAVRGEVQAICTAPLNKEALHAAGHIYPGHTELLAHLTGTDEVSMMLSTPKLKVIHVTTHIGLIDAVARIEPGLVERTIRRGHDALVRSGLAHPKIGVCGINPHAGENGLFGYGEEEQKIIPAVDKLKAEGLDVHGPLPADTAFFLAGRGDYDLIVAMYHDQGHGPVKVLGIEAGVNITVGLPVIRTSVDHGTAFDIAGKGIAEHGSMIEALRQATELATSTATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKG0</accession>
    <name>A0A132PKG0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851216.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22825">
        <property type="protein sequence ID" value="KWX22825"/>
        <property type="gene ID" value="AFM11_17970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.950"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="208" mass="20898" checksum="19F5DB48BBE9FC0E" modified="2016-06-08" version="1">MDAENDELAPGKTLLFPPWCRRVGMAAGFAALIAAVGSVVTDPGEPGTAPGVTTGASAGSSSFSLIATSEWWEPPPPAPPPPAAAPAPAPAPAPAPRRAVPRPAPQPAAPAPPPAPPPPPPPQLVFRFDQPGTATVAIANSDKPVGCMFTSVAVSGTATAIGYRRDYPFTVAGSAETRIAPDGPATGSTFRVTVNCDNGLSSTIDTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKH1</accession>
    <name>A0A132PKH1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dUTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18020</name>
        <name evidence="3" type="ORF">AWC31_12090</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851231.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12090"/>
    <dbReference type="EnsemblBacteria" id="KWX22831">
        <property type="protein sequence ID" value="KWX22831"/>
        <property type="gene ID" value="AFM11_18020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18728">
        <property type="protein sequence ID" value="ORX18728"/>
        <property type="gene ID" value="AWC31_12090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.960"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025242">
        <property type="entry name" value="DUF4193"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13834">
        <property type="entry name" value="DUF4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="100" mass="10970" checksum="398DAE208FFD5284" modified="2016-06-08" version="1">MATDYDAPRRTETDDVSEDSLEELKARRNEAQSAVVDVDESETAESFELPGADLSGEELSVRVVPKQADEFTCSSCFLVHHRSRLASEKNGVMICTDCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKV3</accession>
    <name>A0A132PKV3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_16515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850650.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22980">
        <property type="protein sequence ID" value="KWX22980"/>
        <property type="gene ID" value="AFM11_16515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.652"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="438" mass="46962" checksum="DEB21D47D20EBF62" modified="2016-06-08" version="1">MIESTTPATRERPSRVVAASLTGTVIEWYEFFIYGTSSALVFSKLFFPNYDSFVGTLLSLSTFAIAFVARPVGAAVVGHYGDRVGRKTLLIVTLCMMGGATFLMGLLPTYASIGVAAPIALVVLRLIQGVSLGGEYGGAVLMSVEHAEPKRRGLFGGIINTGASCGLILATAVFFVLSYLPDESFMAWGWRVPFLLSAVLLVLGLVIRLKIAESPEFEQAKKRGKVQKLPLWTVITEHGGLVLLMAISYLPTGAVFYLSAVFSLSYGTETLGFSRSVMLGLVCGSNIIGIAGIVYGGALSDRISRQRVFMLGALGMVFVPWIWFLMMGTANLWVMFLAYLVLFAPFCLSYGAMPAYYAQVFPVHIRYSGMSVGYGIGTVLGAGLSPLIATALLGTDDNWPAVAMFLSVLALASFFATKMMPTVASDRDVVVKSPQPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL14</accession>
    <name>A0A132PL14_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_18600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851470.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12625"/>
    <dbReference type="EnsemblBacteria" id="KWX22944">
        <property type="protein sequence ID" value="KWX22944"/>
        <property type="gene ID" value="AFM11_18600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1057"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="190"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="424" mass="46047" checksum="8753D449461FD372" modified="2016-06-08" version="1">MLNVGIHTGSWQRSSEAPTAFADPGYYVRMARIAERGRLDALFLADGPALREHPALRPSQALEPSVILASVAAETEHLGLIGTLSSTFNDPVELAHRLLALDDLSGGRLAWNIVTTYSLPAGGNFGLADYPDRPTRYRRAAEFVDVVRALWRDAADPSGRGIDHHGEFFTVVGSLPQGPSPQGYPLLVQAGGSPQGRELAGRVADAVFSAELDLGAGIDHYRYVKDVAVAHGRRRGDVKILPGLITTIGSDRVEAERRYDEQNALLPVGHDLERLSQVLGEDLSAHPLDEPVPARLLGEVADPAKFGASLGFRESVVRLIESRNLTLREAVREFSGAGHRVVVGSPADVADTIERWFLAGAADGFNLMPDVFPDGLEIFVDEVVPLLQRRGVFRTEYTESTLRERFTGYAYPVGVPTLVTTRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL56</accession>
    <name>A0A132PL56_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">corA</name>
        <name evidence="8" type="ORF">AFM11_17105</name>
        <name evidence="9" type="ORF">AWC31_01675</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850862.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01675"/>
    <dbReference type="EnsemblBacteria" id="KWX23080">
        <property type="protein sequence ID" value="KWX23080"/>
        <property type="gene ID" value="AFM11_17105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13263">
        <property type="protein sequence ID" value="ORX13263"/>
        <property type="gene ID" value="AWC31_01675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.774"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX13263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="368" mass="41399" checksum="98D1002DA3AAFDD8" modified="2016-06-08" version="1">MPSFRALPPSLLRPGARDRTSPADATNIHVPVARAMVDCGVYSEGQRLPGKFTHAGAVEKVRELQAADKKAFVWIGLHEPDEFQMQSVADVFGLHELAVEDAVHAHQRPKLERYDKTLFLVLKTVNYVEHESVSNAREIVETGEIMIFVGPDFVVTVRHGEHGGLAGVRKRLDASPAILKLGPFAVMHAIADHVVDSYLDVTDLMETDIDAMEEDIFSPRTQTNIECIYLLKREVVEMRRSVGPLTLALARLLTDHNDLISVEVRRYMRDVHDHNVQASERITSYDEMLSSLVQAALGKVAMQQNVDMRKISAWVAIAAVPTAMAGIYGMNFDNMPELHWTWGYPMVLLVMATVCFLLYRTFRHNNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL87</accession>
    <name>A0A132PL87_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17250</name>
        <name evidence="4" type="ORF">AWC31_01815</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850919.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01815"/>
    <dbReference type="EnsemblBacteria" id="KWX23106">
        <property type="protein sequence ID" value="KWX23106"/>
        <property type="gene ID" value="AFM11_17250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13290">
        <property type="protein sequence ID" value="ORX13290"/>
        <property type="gene ID" value="AWC31_01815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.803"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX13290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="147" mass="16459" checksum="D2EB287A821770CB" modified="2016-06-08" version="1">MSLRSQVEFVGLRLLHIHDLIYQKTGGRIGHRMPGVPPSLLLHTTGAKTGQARINTLSYARDGENYVVVASMGGAPRSPGWYHNLKANPNIEINVGTKRLKVTAKPILPDDPDYARLWRIVNENNSHRYEAYQKKTSRPIPIVVLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLH1</accession>
    <name>A0A132PLH1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15900"/>
    <dbReference type="EnsemblBacteria" id="KWX23189">
        <property type="protein sequence ID" value="KWX23189"/>
        <property type="gene ID" value="AFM11_15280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7170"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="231" mass="25239" checksum="08A6FBE8B256DB36" modified="2016-06-08" version="1">MSSGRRGQPVAVKLSDAVTLPVQVGASLRHRRFFHPTGVLAQGTIERTAPDGDGLPIRSCEIVGRVSKGIGLPGSLPDIVGLAWRMPPQLSGTPWDILLASTFAGQRILLCPATSWRNVTLSSLMPLKYEDTHWWLRARLTTRFDGGGLALASVDDQLGRTGLEFELEQAPGTEGFRPLARITLRKKVPHGRDVPFDPALHIVPGVSLTPHWLAEFRRAAYERSRTGRGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLN7</accession>
    <name>A0A132PLN7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_15690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850321.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16075"/>
    <dbReference type="EnsemblBacteria" id="KWX23258">
        <property type="protein sequence ID" value="KWX23258"/>
        <property type="gene ID" value="AFM11_15690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7261"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="70"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="260" mass="28028" checksum="57D99388601EC668" modified="2016-06-08" version="1">MNAPTDIPPGTQTLARGLSVIRIVADGARDLRTLVERTGLGRSTTHRLVQLLVREEFLRHGDGGYTLGPALIELGFKALHGNPLPVVARPVLEELSKQVHDTVHLGVIDGDSVLYLDKLPGTRGAEMRSRIGHRMPLTRTGVGMALLLDSPDRWETLYVLDADRVPAPVTAKRADGSEFCTRMHAYAKMGAAMDLEDNEPGIRCVAAPVRDASKAIVGAISVSATRPYMPAARMRGLVPVVRRAAGRISSAMGYRDGPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM03</accession>
    <name>A0A132PM03_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16640"/>
    <dbReference type="EnsemblBacteria" id="KWX23323">
        <property type="protein sequence ID" value="KWX23323"/>
        <property type="gene ID" value="AFM11_16065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7338"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="231"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="394" mass="43095" checksum="451FBCEFA5CB135B" modified="2016-06-08" version="1">MRTPVVLVAGQGDTDRVVEQLSRKPGTVLVRHTYDGQVVLRTVGTAADTSDWPLELAHGCVSCTVRDDLLVLLRRLHRRSDVARIVVQLMPWLEPEPVCWAIDNIHVCVGPGYIDGPAARDVSIEAVVSCVDTSAWLHQAVGEDELDDGRTAAQVVVGQAEFADVLVLTEPEATTLAVLRRLAPRARITVGCDRVEMALAHLEPDSRRGRAASPHDPLLAGEPPLDRDGEVGIVEFTARRPFHPLRLHAAIDLLLDGVVRTRGRAWLANRPTDVMWIESAGGGMHFSNAGKWLAAMDSSERAYVDPERRAMAAIDWDDRFGDRHVSLTVLICGARPDDIVDALRGALLTDDELGRPGEWAHYPDPFGDWHEDPCDDQPGAGETAAPGRHQGEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM73</accession>
    <name>A0A132PM73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_16285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850537.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23364">
        <property type="protein sequence ID" value="KWX23364"/>
        <property type="gene ID" value="AFM11_16285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7382"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="12"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="446" mass="48420" checksum="ADC85EE965D3609E" modified="2016-06-08" version="1">MSAPIPTGLRRVVAASMAGTVVEWYEFFLYGTAATLVFSKVFFAESTSDLDAILAAFVTYAVGFIARPLGGVVFGHFGDKYGRKKLLQFSLLLVGAATFLMGCLPTFNQIGYLAPTLLVVLRFIQGFAVGGEWGGAVLLVAEHSPNQSRGFWASWPQAAVPVGNMLATVVLLLLTTTLSDAAFLSWGWRVAFWLSAVVVLIGYYIRTKVSDAPIFLAAQQEVERVKAVSYGVVEVLTRYPRGVFTAMGLRFAENIMYYLVVTFSITYLKVQVGADTSDILWWLLAAHAVHFVAIPTVGRLSDRFGRRPVYIVGAIGAGVWAFFAFPMMNSANYLVIMGAIIIGLIIHALMYAPQPAIMAEMFPTRMRYSGVSLGYQVTSIVAGSLAPIIAVKLLDVFDSWVPIAIYLACAAAVTLVAALFMRETVGTDLESIDQADREVLAKHGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMC1</accession>
    <name>A0A132PMC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849802.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18455"/>
    <dbReference type="EnsemblBacteria" id="KWX23465">
        <property type="protein sequence ID" value="KWX23465"/>
        <property type="gene ID" value="AFM11_14365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6981"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="167" mass="18988" checksum="57789DA34F9D6C51" modified="2016-06-08" version="1">MGRNERAKIVMTDDEIAEFVERSRTATMATVLPNGRPHLVAMWYAVLDGEIWFETKAKSQKAVNLRRDPTVTVMIEDGLTYNTLRGVSIDGDAEIVDDPETILRVGISVWERYTGTYTDEMRPFVDQMMNNRIAVRVVPSRLRSWDHRKLGLPEMPVGGSTAQYLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMK7</accession>
    <name>A0A132PMK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_14800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849952.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18100"/>
    <dbReference type="EnsemblBacteria" id="KWX23533">
        <property type="protein sequence ID" value="KWX23533"/>
        <property type="gene ID" value="AFM11_14800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7071"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="4">
        <location>
            <begin position="72"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="336" mass="36210" checksum="0A5AE3C6B2A532EA" modified="2016-06-08" version="1">MNQPARKRSGLGRGLASLIPTGPADGGTDALSPRMGDSAADVLLGAPPGAPGEPAPTPVEQIDGEAVGATYREIDPAAIEPNPRQPRQVFDDEALSELVHSIREFGLMQPIVVRAVPGEGDIRYQIVMGERRWRAAQQAGLTAIPAIVRETADDSMLRDALLENIHRVQLNPLEEAAAYQQLLDEFEVTHDELAARIGRSRPLISNMIRLLRLPIAVQRRVAAGVLSAGHARALLSLEGSPEQQEELAARIVAEGLSVRATEEAVTLANRDGKTAPAPRRKPIQMPGLQDVAEKLSTAFDTRVTVSLGKRKGKIVVEFGSVDDLQRIVELMSAQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMR2</accession>
    <name>A0A132PMR2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_12540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848950.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02800"/>
    <dbReference type="EnsemblBacteria" id="KWX23629">
        <property type="protein sequence ID" value="KWX23629"/>
        <property type="gene ID" value="AFM11_12540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6598"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="416" mass="42851" checksum="4C7283C70A752497" modified="2016-06-08" version="1">MSAELIILVLLIATALAFDFTNGFHDTGNAMATSIATGALKPKTAVILAGILNLVGAFLSVEVAVTVTTSVLKIQDSKTGSLVSGIDASTGLTIIFAGLIGGILWNLLTWLFGIPSSSSHALFGGLIGAGLAAIGLAGVNWSGVVQKVLIPAVAAPFIACLVAACGTWLVYRITRNVLKKRREEGFRWGQIATASLVALSHGTNDAQKTMGVIALALITTGHLTGDVKENGLPFWIIASCALAIGLGTYIGGWRVIRTLGKGLVEIESPQGLAAEASSAAIILSSSAAGMALSTTHVATGSILGSGVGKPGAEVRWAVAGRMAMAWLITLPAAGLVGALSFWLSHGVESITGAALAGDGLIFLILVGLSFYMWWRAQQQKVDHKNVNADWDDTTNSVVPADVREATKADKADKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN38</accession>
    <name>A0A132PN38_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849319.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03590"/>
    <dbReference type="EnsemblBacteria" id="KWX23751">
        <property type="protein sequence ID" value="KWX23751"/>
        <property type="gene ID" value="AFM11_13305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6754"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="54"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="588" mass="62554" checksum="42A81DB0322E833C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN46</accession>
    <name>A0A132PN46_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13350</name>
        <name evidence="4" type="ORF">AWC31_03635</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849343.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03635"/>
    <dbReference type="EnsemblBacteria" id="KWX23759">
        <property type="protein sequence ID" value="KWX23759"/>
        <property type="gene ID" value="AFM11_13350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11221">
        <property type="protein sequence ID" value="ORX11221"/>
        <property type="gene ID" value="AWC31_03635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6764"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="22"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="568" mass="62200" checksum="3EAFE1362ED02032" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN70</accession>
    <name>A0A132PN70_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_13485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849407.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23781">
        <property type="protein sequence ID" value="KWX23781"/>
        <property type="gene ID" value="AFM11_13485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6791"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="483" mass="51831" checksum="BAB4518BD039CF1C" modified="2016-06-08" version="1">MKAALGDWKIAEENGWPLLRGERGFGRMAIFLAAFSAAMATWCFTIGGFVSYYLDATAGTFALLAGSLFGILLVTLATLPMCSKYGIDSVVASRAQLGSRGSYLSLLLVYCSTMGWNVILFIYKGRAIAELLISFGVMDRRHYNLCVGVVAVLAIFIVLHLIRRGPEYVRSRGPVIAVLVAVMSLVILLLLLQRVGVDGVLDAVAIAPYDDAAGNWASAIEVLIASNLSWWAYIGTIVRTNPSGRQSLWPVVIGFGLGVGLGSLVGLYTGLVVADSAGDPTHFLISQGGLVVGIIMMAFLLIANVGTAMMGIYAASLAVRQLPKADKLSWKWTIFLVSLPAMVVVGLFANSAETFFGSFLAFLGVAFAPMCGIQIADWYLLRRQHYDVLSLYLSDKTSKYYYAAGFNPVGFVAFISGVATYIYLLDPVTYVYRPPFQYLSATFPAAFAAGLVYLLGASLFLKPRGIGGYGPASTTSEPLISKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN91</accession>
    <name>A0A132PN91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_13665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849468.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03910"/>
    <dbReference type="EnsemblBacteria" id="KWX23809">
        <property type="protein sequence ID" value="KWX23809"/>
        <property type="gene ID" value="AFM11_13665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6829"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="26110" checksum="723A0DB63F7D2B03" modified="2016-06-08" version="1">MSTIQRTAVVTGATSDKGIGVAVAARYAKEGWAVVILDLDGEKSAKVAAEIGNQYAVPAFGHAVDVTSEESVTAAHAAVAAEIASGNLPTVGALANIAGITSPVGFLDTTLELWNKVMAVNATGTYLVTKAFLPDMIEAGWGRIVNMSSVSAQRGGGVFGKVPYSSAKAAILGFTKSLAREIADTGVTVNAVTPGAVDTNIRVGSTDAQEAKLAADIPVGRTATTDEVAAVITFLSSQDASYLTGTTVDINGGSHMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN92</accession>
    <name>A0A132PN92_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849065.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03095"/>
    <dbReference type="EnsemblBacteria" id="KWX23667">
        <property type="protein sequence ID" value="KWX23667"/>
        <property type="gene ID" value="AFM11_12775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6647"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="112" mass="12730" checksum="A5887E2EC76010AB" modified="2016-06-08" version="1">MPDEYLLRGTELRYVLTMQLLQHGPQSVADLVEALREQGFTTKGRPSKTISDALRWEIEHGRVYRIRYGKYRSASMPRSTQYRIGKRVLALRESAAQLSASNADGFWDALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP59</accession>
    <name>A0A132PP59_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848503.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10045"/>
    <dbReference type="EnsemblBacteria" id="KWX24064">
        <property type="protein sequence ID" value="KWX24064"/>
        <property type="gene ID" value="AFM11_11930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6466"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="163"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="407" mass="44436" checksum="164927B9B20E1EED" modified="2016-06-08" version="1">MTARPDTRYSGPSLASRARWLLHAKPADHMLALSVASASLPVVGKHLEPLGAMAAMSVWGFRHVPDFVAASARSWLAPDPAGLRKADRDKTNSVARQALQNLVAAADLAIDWPAPQSMPPLWNTIAHRRSVYRTSVRYGDSPSQLLDVWRPKDLPTEPAPVLIFVPGGAWVHGSRMLQGYALMSHLAQQGWVCLSIDYRVAPHHRWPRHITDVKAAIAWARANVDKFGGDRNFVAIAGCSAGGHLAALAGLTPNHPDLQGDLSESSDTTVDAVVGIYGRYDWEDRSTAERVRFVDFLERVVVKRKIDRHPEIFRLASPIAQIHPDAPPFLVVHGTADTVIPVAQARSFVDRLKAVSHVPVGYVELPGAGHAFDMTDGARTGAMATAIGLFLNEIHRNRTIDRTKAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPA4</accession>
    <name>A0A132PPA4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2786 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12265</name>
        <name evidence="4" type="ORF">AWC31_09715</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848674.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09715"/>
    <dbReference type="EnsemblBacteria" id="KWX24123">
        <property type="protein sequence ID" value="KWX24123"/>
        <property type="gene ID" value="AFM11_12265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09212">
        <property type="protein sequence ID" value="ORX09212"/>
        <property type="gene ID" value="AWC31_09715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6532"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024498">
        <property type="entry name" value="DUF2786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10979">
        <property type="entry name" value="DUF2786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2786" evidence="2">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="247" mass="26656" checksum="4923BC37F0390F64" modified="2016-06-08" version="1">MADDKMLARIAALLRQAEGTDNQHEAEAFMAAAQRLATATSIDLALARAHSAERTKSQMPVQRTITIGQAGTKGLRTYVQLFVVIGLANDVKCDVASNSTFVYAYGFAEDIDATHALYASLVLQMVKASEAYIASGAHRPTPTITARLNFQLAFGARIGQRLSEAREEAKREVDEAHRPGTAIALRDKDIELRSFYREASQARGTWRATSASAGYSSAARRAGDRAGKRARLGPSQELSGARGALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPG6</accession>
    <name>A0A132PPG6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Agmatine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848085.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30720"/>
    <dbReference type="EnsemblBacteria" id="KWX23932">
        <property type="protein sequence ID" value="KWX23932"/>
        <property type="gene ID" value="AFM11_11180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6313"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="338" mass="36682" checksum="96D904C7F0BD8700" modified="2016-06-08" version="1">MTRYVMPAEGVPQDRVWMAFPCAGYSLGDTEQEQHEARSTWAAVAHAIVQFEPVTMLVDPAEMNAAKQYVSQQVELVEAPLNDAWMRDIGPTFVHAADGSVAAVDWVFNGWGGQDWARWDRDAKIGATVAELAGVELVPSPLVNEGGGIQVDGEGTVLVTETVQLDPGRNPTATKADVEAELARTIGATDVVWLPRGLTRDSQRFGTRGHVDIVAAFTQPGRLLLHTQQDEQHPDNVVSKEIRSVLEDRFDVVDMPAPATLTDAEGYVDYSYINHLVVNGGVIACSFDDPRDADAVAILAEQYPGREVVSVDARPLFARGGGIHCITQQQPSPITTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPJ0</accession>
    <name>A0A132PPJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxypyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hyi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847247.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05520"/>
    <dbReference type="EnsemblBacteria" id="KWX24259">
        <property type="protein sequence ID" value="KWX24259"/>
        <property type="gene ID" value="AFM11_09705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5979"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="3">
        <location>
            <begin position="44"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="27353" checksum="9119B2D9B2B6AA1D" modified="2016-06-08" version="1">MTFQLAVCSEMVFTDLDIVDRARHIDELGFAVEIWSFHDKDLDALAATGARFSSMTGYLHGDLYDPAGSREVVRTAEQAVKAAAVLGVPRLVVHPGELVDGQAARPRYRATGEMWLSALRGLEALGELGAAAGVTFCLENLNTIVDHPGVPLARAKDTLALVEAVGHPNVKMMLDLYHAQIGEGNLVDLVHRAGQAIGEIQVADVPGRCEPGTGEIHYPAVAKALRDSGYTGTVGMEAYAAGDSVAALEAFRAAFSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPS2</accession>
    <name>A0A132PPS2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_10220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847521.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18665"/>
    <dbReference type="EnsemblBacteria" id="KWX24346">
        <property type="protein sequence ID" value="KWX24346"/>
        <property type="gene ID" value="AFM11_10220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6082"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="5">
        <location>
            <begin position="44"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="362" mass="39616" checksum="A7484083F49485D1" modified="2016-06-08" version="1">MAIGVEPVELELDPVRLVDADGSPTTEVRYSRELPPETLAWLYESMVVTRELDTEFVNLQRQGELALFASCRGQEAAQIGAAACLRKTDWLFPQYREIGAFLLRGITPGQMGAVWRGKWHGGLDFTSKCVAPIAIPIGTHGLHAVGAAMAAQRLREDSVTVAFLGDGATSEGDAHEALNLASVFGAPCVFFVQNNQWAISVPVSRQQAGPSIAHRAIGYGMPGIRVDGNDVLACYAVMAEAAERARHGVGPTLIEAITYRMGPHTTSDDPTRYRSADEVDEWRARDPIVRYRTYLEFVGVWSERLQERVAARSARLCADLREAVAGAPDFDPAEMFDSVYAEITPDLARQRDQLLAELAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPX3</accession>
    <name>A0A132PPX3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847655.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24389">
        <property type="protein sequence ID" value="KWX24389"/>
        <property type="gene ID" value="AFM11_10505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6141"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016793">
        <property type="entry name" value="UCP021591"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021591">
        <property type="entry name" value="UCP021591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453232" evidence="1">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="142" mass="15245" checksum="99940FDE626A8BEB" modified="2016-06-08" version="1">MRSVSALATAAGALTLIGGGLTVAVPAAADTPVLHHVRYTVTSDAPFWAEIYYRATDPPTWSDYSHNPYQFSPKAEADIGPNQPWVYDAMLADPDSWAMVTVQSGDGPGIEPPRFHCRLEVDGAVVKTNSGNKGALCSLRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ20</accession>
    <name>A0A132PQ20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847818.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19330"/>
    <dbReference type="EnsemblBacteria" id="KWX24440">
        <property type="protein sequence ID" value="KWX24440"/>
        <property type="gene ID" value="AFM11_10815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6202"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="260" mass="28549" checksum="86F9C5F35671C1E9" modified="2016-06-08" version="1">MYIDYDVADAIATITLNRPEAANAQNPELLDELDAAWTRAAEDTAVKVIVLRANGKHFSAGHDLRGGGPVPDKVTLEFIIEHESRRYLEYTLRWRNVPKPSIAAVQGRCISGGLLLCWPCDLILAADDALFSDPVALMGIGGVEYHGHTWELGARKAKEILFTGRALTAEEAERTGMVNRVVPRDELDAQTMELAGRIAKMPSFALRQAKRAVNQTLDVQGFYAAIQSVFDIHQTGHGNALSVSGWPVLMDINEMKANIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ27</accession>
    <name>A0A132PQ27_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PE-PPE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_12375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848760.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24142">
        <property type="protein sequence ID" value="KWX24142"/>
        <property type="gene ID" value="AFM11_12375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6554"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013228">
        <property type="entry name" value="PE-PPE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08237">
        <property type="entry name" value="PE-PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453488" description="PE-PPE domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="PE-PPE" evidence="3">
        <location>
            <begin position="395"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="709" mass="74813" checksum="1A8C9B95F5C223B7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ39</accession>
    <name>A0A132PQ39_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847429.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18530"/>
    <dbReference type="EnsemblBacteria" id="KWX24317">
        <property type="protein sequence ID" value="KWX24317"/>
        <property type="gene ID" value="AFM11_10045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6045"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033437">
        <property type="entry name" value="DUF5130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17174">
        <property type="entry name" value="DUF5130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="16375" checksum="6310570B4493381D" modified="2016-06-08" version="1">MASGSHTTELATAPPADLELPYGYALTSSGRISGVTEPGELSVHYPFPTMDLVVLDDALKYGSRAAKARFAVYIGGLGVDTAATAREILAKVPTPNNAVLLAVSPDQHAIEVVYGADVKGRGIEEAAPLGVSAAAASFKEGNLIDGLISAVRVLSAGVSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQC8</accession>
    <name>A0A132PQC8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847712.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19125"/>
    <dbReference type="EnsemblBacteria" id="KWX24407">
        <property type="protein sequence ID" value="KWX24407"/>
        <property type="gene ID" value="AFM11_10610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6162"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="195"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="36234" checksum="6DC943FA81983C58" modified="2016-06-08" version="1">MLLEFDADQRLWQETVRDAVTKQCPATLVREVAEQDVDPTPLWKSYIDQGWTELTDPENAVELAIVLEELGRATDLTPYLATMTQFAPLAGDRFDAAHAGTAVYSGVAAHRDASGWVLTGTAHHVLDGDRAESLAVVTDAGVFLIDAGTAVVRRSPIFDPVLHVAEVSFDDVHVPDTDRVHADTDKARHLALTGMAVTTVGACQRVLDLALEHVKQRQQFGVAIGSFQAVQHKAVDMHVAIERARALSYFAALTIAADDPRRRLASAMAKAAAGECQAIVFRHGLQLFGAMGFTWENDVQFALKRAKAGELLLGGAAEHRAVIAAEYRTSYRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQF6</accession>
    <name>A0A132PQF6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_07750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846106.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24375"/>
    <dbReference type="EnsemblBacteria" id="KWX24569">
        <property type="protein sequence ID" value="KWX24569"/>
        <property type="gene ID" value="AFM11_07750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5399"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="486" mass="50131" checksum="440347868DDD3B47" modified="2016-06-08" version="1">MTTDAVLEPGVATGGQGRRLAGRLGPTAIVFMVVAAAAPLTVVAGTFPIGIAAGNGAAFPASYVVCTAVLLLFAVGFTAMARHIRGAGAFYTYIAHGFGRHVGLGAAFLALLSYTAVQGGVYGYIGAALDGFVTAHGGPSVPWYLYALAMLAVVGMLGYRHIELSGKVLGILLVCEVGIVLVINLAVIGRGGAEGLSTAVLHPGNFFAGAPGIALIFALAGYIGFEATAVFRDEARDPARTIPRATYVALLLIGGFYALSSWAMVSAWGDGGVVAMAADNPEGILTETATRYVGSVTGDLVQIFLITSLFAALLSFHNVLSRYIFSLGNTRALPRRCGRSHIRHSSPHIASVVQTVSALVLIVASVLTRLDPVTQVFAWFVGTASVGIVVLMTLTSAAVVVYFRRTRFDTRVWHTLIAPGLGFLGLAALSVLTAANLPLLVGGSATLAAVIGVLLAGTFLGGAAVAVLRPHAGHHENPEIAKEIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQL2</accession>
    <name>A0A132PQL2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08020</name>
        <name evidence="3" type="ORF">AWC31_24620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000014">
        <property type="protein sequence ID" value="ORX15212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846241.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24620"/>
    <dbReference type="EnsemblBacteria" id="KWX24618">
        <property type="protein sequence ID" value="KWX24618"/>
        <property type="gene ID" value="AFM11_08020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15212">
        <property type="protein sequence ID" value="ORX15212"/>
        <property type="gene ID" value="AWC31_24620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5454"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019681">
        <property type="entry name" value="DUF2530"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10745">
        <property type="entry name" value="DUF2530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="89" mass="9322" checksum="79379E0380EA1DBD" modified="2016-06-08" version="1">MTGDPNGSADPAPQPPPLPAALLEPWPVVLVIAAGWLIVTVLAFTVPDLHSWRPYAVAGLGIGALGTSIFLWQRRAVRRGSRGAQSGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR27</accession>
    <name>A0A132PR27_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846362.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24657">
        <property type="protein sequence ID" value="KWX24657"/>
        <property type="gene ID" value="AFM11_08250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5501"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="68"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="133" mass="14935" checksum="F648D2974633DA2E" modified="2016-06-08" version="1">MTERQRPVVIPLSDVTPIPAAEAPTKVRISRIITRAKHGSNLTQGVCWMDPGEETNHWSSAAENDTEPGDHWYGPVDETYYIIAGTLRFTWDEDVVDLKPGDTVYLAPGWTYHLANVSDQPAFFVYNMTPAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR71</accession>
    <name>A0A132PR71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846897.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21950"/>
    <dbReference type="EnsemblBacteria" id="KWX24829">
        <property type="protein sequence ID" value="KWX24829"/>
        <property type="gene ID" value="AFM11_07450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5338"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="272" mass="28238" checksum="05DACC4E97191388" modified="2016-06-08" version="1">MGALEGKIALITGGARGQGRAHATTLAREGADVVVCDIAADVDEIDYPLATAADLDETVAQVKALGRRCLAITADVRDLAAMQAVVDAAIAEFGGIDIVIANAGIASSAPTATMSEKRWRTMIDINLTGVFNTFRAVLPHLIERGGGRIVATSSIVAGTGATNSGHYAAAKAGVVALVKSVAHEVAEHGITVNAVLPSGVNTPMIHNPTTYKVIRPDLENPGLADVEEMFQQGRPRPGLLEPEDVANAVLYLVSEQGRLQTGESMILSNGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRK1</accession>
    <name>A0A132PRK1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_05470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844994.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12845"/>
    <dbReference type="EnsemblBacteria" id="KWX24894">
        <property type="protein sequence ID" value="KWX24894"/>
        <property type="gene ID" value="AFM11_05470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4283"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="133"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="290" mass="29904" checksum="05492ABA105B9D0A" modified="2016-06-08" version="1">MPTNEQRRATAKRKLERQLERRAAQERKRRIYTIVGSAVAAVVVIGAVVATFVITSKDSNGTTASAATTTPADAPAEPAADGQLPAFVAPADLGANCQYPAAGEASKQVNPPRTGKVPTDPANVSVSVVTTQGNIGLQLDNAKAPCTVNSFASLAGQNYFNDTPCHRLTTGGLSVLQCGDPTGTGTGGPGYQFANEYPTNQYQPDNPALQQPVVYPRGTVAMANAGPGTNGSQFFLVYKDSQLPPGYTAFGKIDDTGLATLDKIAAAGVEGGGPDGKPALDVQLKSVALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRP8</accession>
    <name>A0A132PRP8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="10" type="ORF">AFM11_06245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845245.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29430"/>
    <dbReference type="EnsemblBacteria" id="KWX25028">
        <property type="protein sequence ID" value="KWX25028"/>
        <property type="gene ID" value="AFM11_06245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4442"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="34"/>
            <end position="217"/>
        </location>
    </feature>
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            <begin position="219"/>
            <end position="514"/>
        </location>
    </feature>
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        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <position position="178"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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            <position position="208"/>
        </location>
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        <location>
            <position position="212"/>
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        </ligand>
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        </location>
        <ligand>
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        </ligand>
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        </ligand>
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        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF02781"/>
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            <dbReference type="EMBL" id="KWX25028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="516" mass="57791" checksum="193A4199A455262D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRW3</accession>
    <name>A0A132PRW3_9MYCO</name>
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        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06560</name>
        <name evidence="5" type="ORF">AWC31_29115</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
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        </lineage>
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    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="AFM11_06560"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="65"/>
        </location>
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        <location>
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            <end position="140"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX13845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="144" mass="15515" checksum="EF3761E2BA53E453" modified="2016-06-08" version="1">MPVPLIWLILALVLAGAEALTGDMFLLMLAGGALAATGSSWLLDWPIWADGLVFLVVSVLLLVLVRPALRRRFEAGKGLPEPVKALEGKSALVLDRVAQHEGQVKLDGEIWTARPLNDHDVYEPGDQVTVVRIDGATAVVFKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSB6</accession>
    <name>A0A132PSB6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07320</name>
        <name evidence="4" type="ORF">AWC31_17395</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845723.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25213">
        <property type="protein sequence ID" value="KWX25213"/>
        <property type="gene ID" value="AFM11_07320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17475">
        <property type="protein sequence ID" value="ORX17475"/>
        <property type="gene ID" value="AWC31_17395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4664"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453297" evidence="2">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX17475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="107" mass="11573" checksum="2C508A14F1E6CDC1" modified="2016-06-08" version="1">MTFKRTMGVSTLAAGIGLAGLLGLGLQTASAEPGPDCNRPGNQQCGNQHNDNRNDRGPAPVDWNHRGIDQGRADHQPFNWNGHQVTPMPAADGRGWGFWFLGTWIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSC7</accession>
    <name>A0A132PSC7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_07090</name>
        <name evidence="5" type="ORF">AWC31_17625</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845624.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17625"/>
    <dbReference type="EnsemblBacteria" id="KWX25174">
        <property type="protein sequence ID" value="KWX25174"/>
        <property type="gene ID" value="AFM11_07090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17513">
        <property type="protein sequence ID" value="ORX17513"/>
        <property type="gene ID" value="AWC31_17625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4616"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008327">
        <property type="entry name" value="Sig_transdc_resp-reg_antiterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036382">
        <property type="entry name" value="RR_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="13"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX17513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="207" mass="22806" checksum="0D57E65572CFB025" modified="2016-06-08" version="1">MTGSSTDSDKPRRVLVAEDEALIRLDLAEMLREEGYEVVGEAGDGQEAVELAESLRPDLVIMDVKMPRRDGIDAASEIASKRIAPIVILTAFSQRELVERARDAGAMAYLVKPFNVTDLVPAIEVAVSRFAEIAALETEVATLSDRLETRKLVERAKGLLQSKHKMSEPEAFKWIQRAAMDRRTTMKRVAEVVLETLEDPADGAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSI1</accession>
    <name>A0A132PSI1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_03185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843875.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21910"/>
    <dbReference type="EnsemblBacteria" id="KWX25306">
        <property type="protein sequence ID" value="KWX25306"/>
        <property type="gene ID" value="AFM11_03185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2511"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008585">
        <property type="entry name" value="Gamma_PGA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038128">
        <property type="entry name" value="Gamma_PGA_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="PTHR12935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05908">
        <property type="entry name" value="Gamma_PGA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="3">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="351" mass="38285" checksum="70C0853267EE16EB" modified="2016-06-08" version="1">MLHPYFAYGSNLCVAQMARRCPGAVDPRPARLDGHDWLINQRGVATIEPFDGSHVHGVLWHVTDHDLDALDSAEGVPVRYRRDRLTVHTADGAAPAWVYIDHRVDPGPPRPGYLERILAGAVHHELPHRWIEFLRRWDPMHWPQRALATTSPAPESLSELLAAPGIVESATLRSRFGFMAIHGGGLEQMTDVIAERAAAASDASVYVVRHPDHYPHHLPSAQYLSHESARLTAFLDHVDAVVSLHGYGRMGRGTHLLAGGRNRALAEHVAQHVAIPGYHVITDLDAIPRELRGQHPDNPVNRANGVQLELPSRVRGLSPRSPLPGDDGLSPVTSALVDGLAAAARSWSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSQ4</accession>
    <name>A0A132PSQ4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844114.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21525"/>
    <dbReference type="EnsemblBacteria" id="KWX25376">
        <property type="protein sequence ID" value="KWX25376"/>
        <property type="gene ID" value="AFM11_03630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2601"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="282" mass="31015" checksum="6BFB4AB1E945EE17" modified="2016-06-08" version="1">MDYGLVLFTSDRGITPASAAKLADDHGFTTFYVPEHTHIPIKREAAHPTTGDESLPDDRYMRTLDPWVSLGTACAVTSRVRLSTAVALPVEHDPITLAKSIATLDHLSGGRVSLGVGFGWNTDELADHKVPPGRRRTMLREYLEAMRALWTEEEASYDGEFVNFGPSWAWPKPVQSHIPVLVGAAGTEKNFKWISRSADGWITTPRDFDIDEPVKLLQDTWAAAGRDGAPQIVALDFKPDAEKLAHWRELGVTEVLFGLPDKSESEVAAYVERLAGKLAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PST7</accession>
    <name>A0A132PST7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="7">5.4.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_06580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the methylmalonyl-CoA mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845865.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29095"/>
    <dbReference type="EnsemblBacteria" id="KWX25257">
        <property type="protein sequence ID" value="KWX25257"/>
        <property type="gene ID" value="AFM11_06580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4511"/>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019652">
        <property type="term" value="P:lactate fermentation to propionate and acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004608">
        <property type="entry name" value="MMCoA_mutase_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00642">
        <property type="entry name" value="mmCoA_mut_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="11">
        <location>
            <begin position="47"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX25257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="618" mass="64053" checksum="7DB8EDB8D89B0632" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSV4</accession>
    <name>A0A132PSV4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844169.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25390">
        <property type="protein sequence ID" value="KWX25390"/>
        <property type="gene ID" value="AFM11_03730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2622"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453260" evidence="1">
        <location>
            <begin position="36"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="185" mass="18493" checksum="0CD14024AEA6366D" modified="2016-06-08" version="1">MAKHRKISERSVRTRTLVGGVLAGGALAVAGPAGAAFAVPTDTGNPSADAVGRASLDNPAPGVRAAQAIGDHVFNQNTPVNKALDDSGLGRVYHLNFGTTSADGITPGKNGVVVGELNVNAGKYYYDQAQAAGLPLPGEKDLPGVVPKVLSGNAKAVKTGSAEKVSNTCTASTAKTKVSAQAASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSW6</accession>
    <name>A0A132PSW6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">AFM11_04055</name>
        <name evidence="10" type="ORF">AWC31_21100</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844343.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21100"/>
    <dbReference type="EnsemblBacteria" id="KWX25441">
        <property type="protein sequence ID" value="KWX25441"/>
        <property type="gene ID" value="AFM11_04055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16533">
        <property type="protein sequence ID" value="ORX16533"/>
        <property type="gene ID" value="AWC31_21100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2689"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="36"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX16533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="303" mass="33637" checksum="B418590B0159B708" modified="2016-06-08" version="1">MTIRLLGRTEIRRLAKEIDFRPRKSFGQNFVHDANTVRRIVSASGVHRNDHVLEVGPGLGSLTLALLDRGARVTAVEIDPLLARQLPATIADHSHSEINRLTVLNRDILTLMPADLTEQPTALVANLPYNVAVPALLHLLAEFPSIRTVMVMVQAEVAERLAAEPGGKDYGVPSAKMRFYGNVRRHGMVSPTVFWPIPRVYSGLVRLDRYENPAWPMDAEFRDEVFNLIDIGFAQRRKTSRNAFAEWAGSGNESAERLLAASIDPSRRGETLGIADFVRLLQRAKEAAGDAWESKTAETIRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTD7</accession>
    <name>A0A132PTD7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">AFM11_04875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844660.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20270"/>
    <dbReference type="EnsemblBacteria" id="KWX25575">
        <property type="protein sequence ID" value="KWX25575"/>
        <property type="gene ID" value="AFM11_04875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2856"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="33"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="168"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="487" mass="51588" checksum="815AF873054BF529" modified="2016-06-08" version="1">MAADPSSSLPASSGVDYAETASAAYQAALQVIESVEPRVATATRKELADQRDSLKLIASENYASPAVLLTMGTWFSDKYAEGTVGHRFYAGCQNVDTVEALAAEHARELFGAPYAYVQPHSGIDANLVAFWAILATRVEAPELANFGAKHVNDLSEADWETLRNKLGNQRLLGMSLDAGGHLTHGFRPNISGKMFHQRSYGTNPETGFLDYDAVAAAAREFKPLILVAGYSAYPRRVNFAKMREIADEVGATLMVDMAHFAGLVAGKVFTGDEDPVPHAHVTTTTTHKSLRGPRGGMVLATEEFAPAVDKGCPMVLGGPLSHVMAAKAVALAEARQPAFQTYAQQVADNAQALADGFVKRDAGLVTGGTDNHIVLLDVRSFGLTGRQAESALLDAGVVTNRNAVPADPNGAWYTSGIRLGTPALTSRGFGADDFDRVAELIVDVLSNTAAEGTSKAKYKLADGTAERVHAASAELLDANPLYPGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTT7</accession>
    <name>A0A132PTT7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actinobacterial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_00005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842014.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33110"/>
    <dbReference type="EnsemblBacteria" id="KWX25725">
        <property type="protein sequence ID" value="KWX25725"/>
        <property type="gene ID" value="AFM11_00005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="207" mass="22293" checksum="7BF99A4711EEA844" modified="2016-06-08" version="1">MSNDVWPMVHAERAALIADLERLDDSAWQAASLCDGWSVHDVVAHLVDVAMTTRVGFLLDMARARFDFDRQNARGVARARGASPHETLERLRRAASRTSTPPAPLDTRLVEEVVHGEDIRRPLGITRAYAAEAVTRSLRQQARTSRSFGGAKELLTQVRITATDTDLAIGDGPEVSGTALALLLAISGRRVALGELDGPGLPALATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTV8</accession>
    <name>A0A132PTV8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="8" type="ORF">AFM11_00245</name>
        <name evidence="9" type="ORF">AWC31_33355</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842138.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33355"/>
    <dbReference type="EnsemblBacteria" id="KWX25766">
        <property type="protein sequence ID" value="KWX25766"/>
        <property type="gene ID" value="AFM11_00245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11577">
        <property type="protein sequence ID" value="ORX11577"/>
        <property type="gene ID" value="AWC31_33355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.50"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX11577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="217" mass="22931" checksum="17DC9298C3FEE2B0" modified="2016-06-08" version="1">MARKGILGTKLGMTQVFDENNKVVPVTVVKAGPNVVTRIRTTERDGYSAVQLAYGEISPRKVNKPVAGQYAAAGVNPRRHLAELRLDDEAAAAEYEVGQELTAEIFADGAYVDVTGTSKGKGFAGTMKRHGFRGQGAAHGAQAVHRRPGSIGGCATPGRVFKGTRMSGRMGNDKVTTQNLKVHKVDAENGVLLIKGAIPGRNGGLVVVRSAIKRGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU94</accession>
    <name>A0A132PU94_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermidine/putrecine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_01050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842564.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34080"/>
    <dbReference type="EnsemblBacteria" id="KWX25908">
        <property type="protein sequence ID" value="KWX25908"/>
        <property type="gene ID" value="AFM11_01050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.215"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453637" evidence="2">
        <location>
            <begin position="29"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR019574-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="356" mass="38341" checksum="10E0D71A3C6AA50E" modified="2016-06-08" version="1">MQKTTRPKRRVACIALAVASALALTACGGSDSGEANELNLYAWAGEVPDSVIEAFEKETGISVNVDTFDSNETMIAKLSAGNTGYDIVEPSQYAVQNLAGQNLVDPIDYSRVQGMDNVMDKFVNPGFDPENKHAVPWVWGTTGLLYNQACTKAPLTSWNSLFDPAYRGKIYMLDNMLASYIVGLQSTGSSATSTDEAEIERATEKLLQQKPLLAGYNSTNYYDLVAAGDACASLAWGGSSVGKVVAANPDVKYTLPVEGGTLWVDSFSIAKGAPHPDAAYQWLNFVLRPEVGAMATNDGSLATTNQAAQTLITDPSVRENPAIFVSDDQLRKAEFILDPGEAMKYYQDGWTRIKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUG2</accession>
    <name>A0A132PUG2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-ribbon domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_01395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842750.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34365"/>
    <dbReference type="EnsemblBacteria" id="KWX25960">
        <property type="protein sequence ID" value="KWX25960"/>
        <property type="gene ID" value="AFM11_01395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.286"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="405" mass="42810" checksum="2CC21F7C19219C45" modified="2016-06-08" version="1">MTETPDTPDEDAVPTTECRVCKVDVPAGKYCGLCGVHLNEEPGDGPEWLRVTASCVAPEEHLLKPSITSSLFPHLSHRARTPFRVLLVVLLAGLVACALLRLPAALIAVAALGLPLLFLIYLWESDAFSDLPGSTLALTAVLGIALGVGWVFLTGAMMARSYGVPLGSGISGYRILRNGLGVPLGGLILMLVPALVIRLLRPPTRESLDGFMIGALGATAFTAAATLTRLAPQLTTGMVAHNRPMSGLLVEAGIRGVAMPLTAAAVGGLIGAALWFTRPPSKVDQHPGYVRAVLLGCGIAVLVVYAGIGLIDVARVPQWLQLAVHLVVAVVALFTLRVGLHLALLHEAHDEIASDQPILCPRCGHVVPDMAFCAHCGAATRASSRTSRTERRENRPVRERRPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUI8</accession>
    <name>A0A132PUI8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_01855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842957.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34635"/>
    <dbReference type="EnsemblBacteria" id="KWX26019">
        <property type="protein sequence ID" value="KWX26019"/>
        <property type="gene ID" value="AFM11_01855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.381"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX26019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="443" mass="46456" checksum="FC0D2892B05E6D62" modified="2016-06-08" version="1">MSTPDNAAESSFETKQIHAGQTPDSATNARALPIYQTTSYTFNDTAHAAALFGLEQPGNIYTRIMNPTTDVVEQRIAALEGGVAALFLASGQAAETFAILNIAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVANPDDLDSWRAAVQPNTKAFFAETISNPQIDVLDIPSVAAVAHDNGVPLIVDNTIATPYLIQPLAHGADIVVHSATKYLGGHGSAIAGVIVDGGTFDWTNGKFPGFTEPDPSYHGVVFAELGAPAYALKARVQLLRDLGSAAAPFNAFLIAQGLETLSLRVERHVANAQRVAEYLAGHPDVTSVNYAGLPTSPWYELGRKIAPKGTGAVLAFELSGGIEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHQQLTAEEQLSTGVTPGLVRLAVGLEGIDDILADLEQGFAAARPFSGASQTASTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUP4</accession>
    <name>A0A132PUP4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium:solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_02115</name>
        <name evidence="8" type="ORF">AWC31_34895</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843081.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26061">
        <property type="protein sequence ID" value="KWX26061"/>
        <property type="gene ID" value="AFM11_02115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11838">
        <property type="protein sequence ID" value="ORX11838"/>
        <property type="gene ID" value="AWC31_34895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.433"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX26061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX11838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="477" mass="49951" checksum="8CF0FDE01ED5C70F" modified="2016-06-08" version="1">MNALTVFIVIGLVAIGVLGVAGRRATKLDEWTVSGRSFRRWRSWFLQAGESLTTFSFLGLSGIAFGGGVSATFALAYLSISAIGLYFVAPRLWQLGKGRGYLTMADFFIDRFNSPVLGKVVAVVGAIFLLPYLELQITGLGLIVELATGSESSRGLSMVIASALVIVFVVWAGIRGVSRVAVLKDALMVVALLIVVGGVAFGITGIPDVFAQVHRDQPVLLTLSAPGYDTTFFLTAVVVTSIGAGLNVFPHLWPPVFAARSGEILRSNYTWLALYQLLLFAPIIVGLGAILILPADTTGNHVLLDTATHTLPDWLVAVVAISGASAAMVPAAAIAMGISTLVSRNLIKVGNEKTRMRMNTVVVAAAITLALVFGLGGASIASLLLLTYGGLTQLAPAILVALRGRVTVGAVPVLAGIVVGVLVVSWITFFEIPIGSWDSGFIALGPNLVVLIVAEAIRRRLPKPAGTTVKSEVPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUT5</accession>
    <name>A0A132PUT5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_01175</name>
        <name evidence="7" type="ORF">AWC31_34215</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842629.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34215"/>
    <dbReference type="EnsemblBacteria" id="KWX25927">
        <property type="protein sequence ID" value="KWX25927"/>
        <property type="gene ID" value="AFM11_01175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11728">
        <property type="protein sequence ID" value="ORX11728"/>
        <property type="gene ID" value="AWC31_34215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.241"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX11728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="155" mass="16412" checksum="C46A924821A839BB" modified="2016-06-08" version="1">MAERSSGSAELPTAEDTIALGASLGEGLQAGDVVVLSGPLGAGKTVLAKGIAQAMDVDGPVVSPTFVLARVHRARQAGRPAMVHVDMYRLLDHPGADLLGELDALDLDTDLDDAVVVVEWGEGLAERLSEHHLDIRIERDSATDVRTAIWQWSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVR7</accession>
    <name>A0A132PVR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843652.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26257">
        <property type="protein sequence ID" value="KWX26257"/>
        <property type="gene ID" value="AFM11_01660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.342"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="145"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="31655" checksum="DFA34E09E9F04227" modified="2016-06-08" version="1">MSEVVALGYLGLHATDLDAWRAYGTEILGLQDVSAQRNCDDRTVLLRADGRGWRLAIHQADTGGAAYVGWEVPNAAALDALAQRLTATGVAISEDPDCAAERHVEALVRCTDPDGHRLEFFYGARVPKRPFVSPRGIRFVTGDLGLGHVFFFVTDLAATKEFYLDVLGFRLSDTIAFHGRKVHFAHVNPRHHSLAFVENDKLAPALGHFMLEVSDIDDVGRTLDAVHAGGVPLTETLGRHTNDLAISFFMKNPSGSEVEYGYDGRLVDDATWRVSSYDATSLWGHHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVT7</accession>
    <name>A0A132PVT7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843715.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34875"/>
    <dbReference type="EnsemblBacteria" id="KWX26277">
        <property type="protein sequence ID" value="KWX26277"/>
        <property type="gene ID" value="AFM11_02095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.429"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="418" mass="45577" checksum="4F04B19D162C5684" modified="2016-06-08" version="1">MSSQETEVLVVGAGQAGIAMSEHLGLHGVPHLVVERDRIAERWRSWRWDSLVANGPAWHDRFPGQEFNIDPDAFAGKEQVADYLVSYAEKIDAPIRTGVEVRSVRKNNGRAGFHVETSDGPIEARYVVAATGAFQKPVVPPVVPDSAGIHQIHSSAYHNPQQLPDGSVLVVGAGSSGVQIADELQQSGRQVYLAVGPHDRPPRSYRGRDFCWWLGVLGKWDMATPPRGAEHVTIAVSGAHGGHTVDFRSLAASGITLLGMAGPFADGVMRIAPDLRKNIESGDANYLSMLDEADAYVARNGLDLPEEPQARILGPYPDCVTHPILELDVAAAGITSIIWAVGFAFDYGWLQVDAFDECGRPKHQRGVSSEPGVYFLGLPWQSRRGSSFIWGVWHDAKYLADQIAIQRSYLAYKATDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVX8</accession>
    <name>A0A132PVX8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_02840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843475.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26182">
        <property type="protein sequence ID" value="KWX26182"/>
        <property type="gene ID" value="AFM11_02840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.585"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="440" mass="47724" checksum="6981438E0AB9867A" modified="2016-06-08" version="1">MTTTLEPAEAPAPQEAKQPVPLSPLLVRLAIAPLLLAAFTSTMAILNLAGPVSFGDFFVGLSLLTLLPLVIIGRRGFTIPAWMFIPAVVIPICVLVRQIDPPPYFWRVLRLQVQQYHPESFGKAMLWLAAIYIVPIAVIAASRIEPRVVEWVMGAYAAGVTVSCVVAFTDLIGLTHVRTELDYAAITYSWSDRRFSGLSDHPNNLGYTILISLPFVIYFLSKMRQKWIPGLALVIMVCGLLATGSRSAQGLAPLCVLAAAMCLPNRRAALRVVATAFVGMVGVGTVLLFTVLADKQADILRFTGEGAGGAERANEARLTLFQQALNDWMTYPIFGAGIRHVTEAHNITLQLLAAGGIVLAAGMIAYFAFVFRDCWRLIKGGNYYARFLFISIATWLIAGQAGTYLTGPEMYYTVGCVAALTVATVLRPVDDNAELTAVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PW81</accession>
    <name>A0A132PW81_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35045"/>
    <dbReference type="EnsemblBacteria" id="KWX26282">
        <property type="protein sequence ID" value="KWX26282"/>
        <property type="gene ID" value="AFM11_02265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.464"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453665" evidence="2">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="103" mass="10730" checksum="E2B01B18D9B9F7F2" modified="2016-06-08" version="1">MKQAKRRQTAQHERVRKLWPAAAATLMFVAGLVVTGPPTAQATICGSIGGRHVDVTGCSDPMSELNDALAPPPPPGYVPPPPPPPNISVCANVGRRINISGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PWA1</accession>
    <name>A0A132PWA1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ORF">AFM11_02940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35720"/>
    <dbReference type="EnsemblBacteria" id="KWX26302">
        <property type="protein sequence ID" value="KWX26302"/>
        <property type="gene ID" value="AFM11_02940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.606"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="100"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX26302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="386" mass="41547" checksum="048580CA735DE6ED" modified="2016-06-08" version="1">MIGGGQLARMTHQAAIALGQTLRVLATGPNEPAAQVTPDVVIGQHTDLDALRRAASGASALTFDHEHVPTEHLEQLVAEGVTVAPPPQALVHAQDKLLMRRRLHDLGAPVPRFAAIRSVADIEEFVRLIDGPVVIKTVRGGYDGRGVMMADDLAQAREIVERYLADGVALLAEERVAMRRELAALVARSPFGQGAAWPVVETVQRDGICVEVYSPAPGLSDELGSAAQELGLRLANELGVVGVLAVELFETTGGDLLVNELAMRPHNSGHWTMDGAVTSQFEQHLRAVLDYPLGDTAAIAPAAVMANVLGAPQTPEMSMDERLHHLFARMPEAKVHLYGKGERPGRKIGHVNVIGTDTADLRERAVRAAHWLSHAEWTDGWDEHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAW5</accession>
    <name>A0A132PAW5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_35695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000047">
        <property type="protein sequence ID" value="KWX19460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859915.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12655"/>
    <dbReference type="EnsemblBacteria" id="KWX19460">
        <property type="protein sequence ID" value="KWX19460"/>
        <property type="gene ID" value="AFM11_35695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5875"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX19460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="828" mass="92264" checksum="205F64E2A92D477E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBJ1</accession>
    <name>A0A132PBJ1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19701">
        <property type="protein sequence ID" value="KWX19701"/>
        <property type="gene ID" value="AFM11_34210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5180"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="275" mass="29503" checksum="7A061D858B5B81F6" modified="2016-06-08" version="1">MWDASAPVVVCVDGSDAATNAAIWAIDEAVIRDVPLRIVHVIDVEDVDTANRSACSDQLRLDTQYAESSLRSATAAVEATDKPVKLETEILWGSVESALIEESSHASMICLGSVGIGPIARVLLGSTAATVAENAHCPVAIIRQSHERLPAEGEWVVVGVEDRADNEPVIELAMQEARLRHLPLMAVGLRHHDFGAITYDELDRRAAKWSQSYPDVRVRLETSPGGIAGFLAEYCADSVVLAVVGRVDGETVARIIGPHGQPVVRHGECSLLVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBP5</accession>
    <name>A0A132PBP5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cation_ATPase_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32555"/>
    <dbReference type="EnsemblBacteria" id="KWX19753">
        <property type="protein sequence ID" value="KWX19753"/>
        <property type="gene ID" value="AFM11_33915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5121"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="211" mass="22781" checksum="6E02945640C672CB" modified="2016-06-08" version="1">MAEITASAEDALGSALAHSRSVTEVLEVLGSSGDGLDSDSARDRLATYGPNKLPEKRPRPALLRFFAHFNNVLIYILIAAGVLKAILNEWVDCAVIISVAVINAAVGFLQEGRAQRALDSIRGMLSVTAQVRRDGHWRQVDAQTLVAWHAASLQRVKKRCGGSCLMAVPPRAGGPSLVPVQVDEDSAEQERQLLGEFGLAHSPLPRRNRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC31</accession>
    <name>A0A132PC31_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858948.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08015"/>
    <dbReference type="EnsemblBacteria" id="KWX19854">
        <property type="protein sequence ID" value="KWX19854"/>
        <property type="gene ID" value="AFM11_33740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5085"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="31212" checksum="EF1627C242E71C00" modified="2016-06-08" version="1">MSSVNGKVVFITGGARGVGEEVARRLRKKGAKLVLTDLDEAPLTALAAELGDEHVMTALADVRDLPAMQKAADAAVERFGGIDIVLANAGIASFGSVMQVDPEAFKRVIDVNVVGVFNTVRATLPAVIDRRGYVLVVSSLAAFTSAPGLAAYHASKAGAEYFANTLRLEVAHLGVDVGSAHMSWIDTPLVQDAKADLSTFREMLAKMPGPLKQTTTVAKCGEAFVKGIERRKKRIYCPDWVGLFRWIRPVVATPLAERDIRRFTPELLPRLDAEAAALGRSTSARTEALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC81</accession>
    <name>A0A132PC81_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase RecQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_33060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858470.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17165"/>
    <dbReference type="EnsemblBacteria" id="KWX19926">
        <property type="protein sequence ID" value="KWX19926"/>
        <property type="gene ID" value="AFM11_33060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4944"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="30"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="234"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="691" mass="74474" checksum="A82C14FD31FC3BD5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCJ5</accession>
    <name>A0A132PCJ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858025.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20053">
        <property type="protein sequence ID" value="KWX20053"/>
        <property type="gene ID" value="AFM11_32305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4790"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="50"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="437" mass="46977" checksum="DAC199CFD38EAE31" modified="2016-06-08" version="1">MPILANARVFDGRRMLPGSNTVTVEGDRIVAIDAHAGPVPAGAVDVAGMTLMPGLITSHLHPDFYKFSIAIAATERPGKELPPGVMMAIGVRTCRVLLESGFTGYSGASCAHDIDAQLKMAIADDIIPGPRIRACGHHLGTTGDMNNSGRWWKRYETPGTDVCADGPDAMRLLVREEINRGVETIKIFASAGHGQLHRTTRNMSRDEIATIINTAHERGAKVRAHVSDKAMMMECIELGLDLIDHGDEIDDEVIAAMVEAGTFWVPSLIYPWSLLELGYAAEFGVTREQYDHTRAMLPVAQAAGVRILIGDDYSGIFRDLLDDDPLDHQVGNYGREFAYYGAIDGLSAADVLSWGTCNAGQFLVDEPDRVGVIEPGALADLIVVDGDPLADLSLLSRPAEALKAVIRDGVFVIDRMGSVAAKGVSESGAAHRQLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCK4</accession>
    <name>A0A132PCK4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20046">
        <property type="protein sequence ID" value="KWX20046"/>
        <property type="gene ID" value="AFM11_32250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4779"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="87" mass="9617" checksum="3C90B4873D72E51B" modified="2016-06-08" version="1">MTVLQALADPVRVEIVRQLAAGTGEVTCGEVEVPVAKSTASHHIRTLVVAGVIAEREDGRRKYLRLRRTELDKRFPGLIEAVLRATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCS7</accession>
    <name>A0A132PCS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857772.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20145">
        <property type="protein sequence ID" value="KWX20145"/>
        <property type="gene ID" value="AFM11_31875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4701"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="409" mass="43383" checksum="4F80F350507CA779" modified="2016-06-08" version="1">MAADHTGPLNGIRVLDLADPLAAYGARLLADLGAEVIRVEPVTGRSTVDRPPFWLAPDSPAVSPFERFVNAGKRSVTLDITAPEAEPVLADLLASADVVVESPARMLADSGWSDERVTAANPALIRVQVSPYGRDAVGDAPDDDLVLLGAGGLLHMGGYPDIGPVAVYGQQSTYMASIFAAVAAIVGLIGRQRTGAGMTADVSAQECIAQALEESVMRYALTGEVRAPQGDVAKEAGTGTYRCADGYVSMVAGRLGTAAAWTSLVKWITESDGTATELTDDGWSKFEFRQQPDAIETFRRIFERFAATRTRQELYRGAQERGIALSPVNDLAAVREDAQLNSREFFVGVEDPELGCTITYPGLPYRMSGTPLPGPRPAPRRGADNVSVYVDGLGLGVDELESLSARGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD68</accession>
    <name>A0A132PD68_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-type alcohol dehydrogenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858780.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02160"/>
    <dbReference type="EnsemblBacteria" id="KWX19912">
        <property type="protein sequence ID" value="KWX19912"/>
        <property type="gene ID" value="AFM11_33590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5051"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08252">
        <property type="entry name" value="AL_MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014182">
        <property type="entry name" value="ADH_Zn_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02817">
        <property type="entry name" value="adh_fam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="16"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="35754" checksum="5DFFEB491BD6915F" modified="2016-06-08" version="1">MPDMAAIGSYSALPIDDPEALKDVSVPVPELRPHDVLVRVAAVSVNPVDVKRRRSLTPSTDPVILGFDAAGTVEAVGSEVTTLSVGDEVWYAGDVTRPGTNAEFHAVDERIVARKPKTLSFTDSAALPLTTITAWETLFERFALTAESRGDLLVLGGAGGVGSVLIQLAKALTGVRVIATASRTESRDWALRMGADEVIDHRDLRAQALQVAPDGIDYLFSPHSAGNISTYADIMRPFGHITAIDEPEGLDLVELKAKSIAWHWELMFTRPMTGYDMIAQQRMLGAAADLVDAGTLRSTLTNAIEAFDAAGLREAHGQVESGRMVGKVVVTRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDC6</accession>
    <name>A0A132PDC6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19972">
        <property type="protein sequence ID" value="KWX19972"/>
        <property type="gene ID" value="AFM11_33285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4989"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="21697" checksum="2F69D75C65591EBA" modified="2016-06-08" version="1">MPSLIPPAITKGSLSRSPQPSVLVGATATLRPWLLSDADAVVEAFSDPEIQRWHVRRADSVAEARQWITSWIVSWVDEAQLNWALVDRASDSLMGRVSLKGVDLHDGSAGVAYWMMPAWRGRGLCSQAVLSLCQWAFNEAGFHRIGLAHSVANLASCRVAIKAGFRVEGIRRDAALHADGWHDMHMHALLANQVGELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE93</accession>
    <name>A0A132PE93_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_28925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_040634844.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20658">
        <property type="protein sequence ID" value="KWX20658"/>
        <property type="gene ID" value="AFM11_28925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3666"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="5">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="276" mass="30521" checksum="59AB489DD6972E65" modified="2016-06-08" version="1">MASPLITLNDGNAIPQVGLGVWQTPPEATERAVATALEAGYRHIDTAAAYQNEREVGQALAKSGLRREDVYITTKLWNADQGYDSTLAAFDKSMERLGLEYLDLYLVHWPMPKTNKYVDTFKAFAYLRDQGRIRSIGVSNFEPEHLRTLIDATGVVPAVNQIELHPLLQQQELREVHAELGIATEAWSPLGQGSLLANPTVTSVAEAHGRTPAQVLIRWHIQLGNIVIPKSVTPERIVSNFDVFDFELSEQDMASISSLGDGTRLGPDPRNFEFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEB8</accession>
    <name>A0A132PEB8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040127.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20686">
        <property type="protein sequence ID" value="KWX20686"/>
        <property type="gene ID" value="AFM11_29115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3706"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="64" mass="6580" checksum="49086606F7B211A4" modified="2016-06-08" version="1">MSNTTATRPVIRASTADIAAAAEFLSQMFDVPVMITAADVAMDAPAERHLVMIVAESQSTGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEC0</accession>
    <name>A0A132PEC0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040103.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20671">
        <property type="protein sequence ID" value="KWX20671"/>
        <property type="gene ID" value="AFM11_29015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3684"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="125"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="347" mass="37308" checksum="E3C9777C3EF4328E" modified="2016-06-08" version="1">MSIRKSSIGLVIFLVLCISATWLVSVTLLRQVSGPVATYSAIFTNVAGLHPGDDVRVAGVRVGRVDEISLEKDALAKVTFRVQREQTLYTDTVASVTYQNIVGQRYMGLSPGQDISRRILGDHGQLPVEQTEPSFDITHLLRGFEPLFALLDPSQVENLTNGIIQALQGDSGSVLALITQTSALAELFAGPDQLLGEVIANLNNTMTMLANQNANLQSIITHTRELMVGLGNRRADLAAAVGSIATTVNRLGAISASIQPDLSAMMTREPGLSAHLTADARERFSYFGANLPAMLKGVARSMQSGAYVDVYACDINITIFDFLGRLVPRIVRAATPGNTIKNTPICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEN3</accession>
    <name>A0A132PEN3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Secreted lipoprotein, ErfK/YbiS/YcfS/YnhG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_28630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856199.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32860"/>
    <dbReference type="EnsemblBacteria" id="KWX20799">
        <property type="protein sequence ID" value="KWX20799"/>
        <property type="gene ID" value="AFM11_28630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3606"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452996" evidence="4">
        <location>
            <begin position="31"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="65"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="257"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="418" mass="44762" checksum="4F0B3A35A333EB85" modified="2016-06-08" version="1">MMLSSVRRACLAAALAVLAVLGGVAVTALPDCGEHCQTVASPPQGVPQPSPTEPAKLAITPKPNAEVDPLARVMVTATTGTVASVKMVNDAGKEIPGILTPDAKTWKPTTTLGYGRTYTLTVTAKGPGGMPTKQTSTFTTLTPGYQARVYLNGTSGAPLQDGAKYGVGMVIVARFDEPVTDKASAERRMTVTTEPKAVGAWNWIDDQTAHWRPEKYYKPGTKVTVNADIYGARLGDDVYGAQDEKISFTIGDSHVSIADDKTKQVSVFENGKLVRTMPTSMGMGGTETVGGTTMSFWTPRGIYTVMDKANPVVMDSSTYGLPVNSRLGYKTIIPYATRISMDGIYLHQLNSTIWAQGNTNVSHGCLNLSGENAEWFYNFSVPGDIVEIRNTGGDPLKPDNNGDWTVPWDQWRKGSALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF97</accession>
    <name>A0A132PF97_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855202.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21016">
        <property type="protein sequence ID" value="KWX21016"/>
        <property type="gene ID" value="AFM11_26885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3250"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="208" mass="22082" checksum="B0AC0BFA70D12747" modified="2016-06-08" version="1">MSATIQRVVTSGKFELDGGSWDVDNNIWLVGDDSDVVVFDAAHTAGPIVDAVAGRNVIAVVCTHGHNDHITVAPELATTLDAPVLLHPADDMLWRMSHPDKEFRSVEDGLTLTVGGLDIHALHTPGHSPGSVCWSIPDLNAVISGDTLFQGGPGATGRSYSDFPTILDSISKRLGTLPGETVVYTGHGDTTTIGNEIVHYDDWVARGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFC6</accession>
    <name>A0A132PFC6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaminyl-peptide cyclotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10240"/>
    <dbReference type="EnsemblBacteria" id="KWX20974">
        <property type="protein sequence ID" value="KWX20974"/>
        <property type="gene ID" value="AFM11_27705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3415"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017186">
        <property type="term" value="P:peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="PTHR31270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453206" evidence="1">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="251" mass="26555" checksum="B7733444BF89D7DC" modified="2016-06-08" version="1">MAAAVGVAAAASVSPPHAAADAVPVITPNVVGVVPHDPAAYSEGLEFDGPALYEATGEVAKSQLRQVDPETGRVIRTADLPPDYFGEGIAVVGDRIWQLTYQNGVAIEWDKATFEPIREVPMEVGGWGLCFDGSRLISSDGTDRLSFHDPASFAETGGVTVTRDGAPVNGLNELDCVDGQVWAAAWPDDQFVRIDPATGAVNLAMDVSGLWNSGDRTPRQVVSGIAHIAGQDFLISGKDWPQSYKIRIDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFD5</accession>
    <name>A0A132PFD5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26925</name>
        <name evidence="2" type="ORF">AWC31_06775</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855222.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06775"/>
    <dbReference type="EnsemblBacteria" id="KWX21023">
        <property type="protein sequence ID" value="KWX21023"/>
        <property type="gene ID" value="AFM11_26925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09903">
        <property type="protein sequence ID" value="ORX09903"/>
        <property type="gene ID" value="AWC31_06775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3259"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX09903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="95" mass="10773" checksum="48DF9077703C83A2" modified="2016-06-08" version="1">MNWEFEAEVFQWRGPAPYFFVATPDDVDAFLHDHLGELTYGWGVIPAQVRIGDTEIATSLMPRDGVYLVPLKVALRRAEQIDDGDLVRVRLSVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFI0</accession>
    <name>A0A132PFI0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide 4</fullName>
            <ecNumber evidence="11">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome aa3 subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_27290</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Part of cytochrome c oxidase, its function is unknown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Associates with subunits I, II and III to form cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the cytochrome c oxidase bacterial subunit CtaF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="11"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855392.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07225"/>
    <dbReference type="EnsemblBacteria" id="KWX21081">
        <property type="protein sequence ID" value="KWX21081"/>
        <property type="gene ID" value="AFM11_27290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3333"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021050">
        <property type="entry name" value="Cyt_c_oxidase_su4_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12270">
        <property type="entry name" value="Cyt_c_ox_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017385">
        <property type="entry name" value="CtaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX21081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="139" mass="15230" checksum="9CF2F9DE56AAD1AF" modified="2016-06-08" version="1">MHIEARLFEILTGFFALSAIVYGVLTAMFANGGVEWAGTTALVLTTGLTLITGTFFRFVARRLDTRPEDYEDAEISDGAGELGFYAPHSWWPILIALSFSTAAVGAALWLPWLLVAGICFVLFSAGGLVFEYYWGPEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFR3</accession>
    <name>A0A132PFR3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856266.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33005"/>
    <dbReference type="EnsemblBacteria" id="KWX20822">
        <property type="protein sequence ID" value="KWX20822"/>
        <property type="gene ID" value="AFM11_28775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3633"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="301" mass="32534" checksum="7A3DE38ED7925ABC" modified="2016-06-08" version="1">MQIRNGYAKSGDLDIYYEDMGDLNDPAVLLIMGLGAQLLLWRTGFCEKLVDQGLRVIRYDNRDVGLSTKLSGQRVDSSLPIRMARSFLGLRSPSVYTLEDMADDAAALLDHLGIDSAHVVGGSMGGMISQVFASQHAPRTKTLAVIFSSNNQAFLPPPGFKQLLSVITGPPANSSRQTIIDNAVRISRLNGSPGYPTPEEQIRAEAAELYDRAYYPAGIARHFAAILGSGSLREHDKRITAPTVVIHGRADRLMRPAGGRAVAEAIDGARLVLIDGMGHELPEPVWDEIVGELKTNFANAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFS2</accession>
    <name>A0A132PFS2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855523.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07470"/>
    <dbReference type="EnsemblBacteria" id="KWX21124">
        <property type="protein sequence ID" value="KWX21124"/>
        <property type="gene ID" value="AFM11_27535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3381"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="105" mass="11174" checksum="250C2574747BD4E2" modified="2016-06-08" version="1">MLIIALVLAVIGLAALVTAVVTSNELIAWVCIGASVLGVVLLIVDALRERSRGTKAAAESDEETEDAVATDTDEPVDYPDEPTEAEPEPRSDDVVVDEPTEERKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFT4</accession>
    <name>A0A132PFT4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854907.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22910"/>
    <dbReference type="EnsemblBacteria" id="KWX21190">
        <property type="protein sequence ID" value="KWX21190"/>
        <property type="gene ID" value="AFM11_26405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3150"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="119" mass="12865" checksum="2C84D2A1B7711001" modified="2016-06-08" version="1">MTERPVLKPSAAHPITVTPTGRHVTVRVGGVVVAETDDALTLQESTYPAVQYIPLADVDPSALTRSDTTTYCPFKGEANYYNVGTAEDVIWTYEQPYPAVAEIAGRVAFYADKADITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG74</accession>
    <name>A0A132PG74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854552.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36040"/>
    <dbReference type="EnsemblBacteria" id="KWX21348">
        <property type="protein sequence ID" value="KWX21348"/>
        <property type="gene ID" value="AFM11_25855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3035"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="292" mass="31130" checksum="B6709DE0260A747D" modified="2016-06-08" version="1">MELRHLRYFRAVGEELHFGRAAERLHIAQPPLSQQIRQLERELGVELLIRTTRTVELTPAGRAYLQRTVEILDAVEEAAGQTRRIAAGIEGRVAIGCVGSATYSLLPQLVRALGESLPGVEVSVRGEMLAPAQLEALVSGGIDLALLRPPVMHDGVVTETVRRDRLLAALPADHRLAGRAEVTVNDLRDEDFVVHAGHGRSVMSNLVAAICADAGYVPRIRQEVSETSTLVTLVAAGIGVAIVPAPTAALDIAGVRYVPLAPASLGVDLVAARTQDSAVIANVLGVLRELTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGD5</accession>
    <name>A0A132PGD5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854628.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35890"/>
    <dbReference type="EnsemblBacteria" id="KWX21373">
        <property type="protein sequence ID" value="KWX21373"/>
        <property type="gene ID" value="AFM11_26010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3067"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="32072" checksum="79F05AF648756AF0" modified="2016-06-08" version="1">MKFGVSTFITDEGLSPADLAVALEDRGFDSLFVAEHTHIPVDGPRPPDGDLPPHDYYRSLDPFVALTAAAAVTERLLLGTGIALVVQRDPITLAKEAASLDHLSNGRFQLGVGAGWLREEMRNHGTEPRTRLALMRERVLAMKQIWTTEQAEFHGEFVDFGPIYSWPKPRHVPVLVGGNGPTVHDRVLEYGDGWAPNLVGPPEELAARVKELQRRAADAGRDPIPVTLIGADQRGYLGPDRQGAITPLGERELAILADSGVDHCVFFRDAGAPEGEALRYLDELAELTRPLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGH4</accession>
    <name>A0A132PGH4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_26050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854753.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35850"/>
    <dbReference type="EnsemblBacteria" id="KWX21413">
        <property type="protein sequence ID" value="KWX21413"/>
        <property type="gene ID" value="AFM11_26050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3074"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="322" mass="34166" checksum="6B4561ABDC3BBA6A" modified="2016-06-08" version="1">MHAQTRHSRRGNDDMAMAPADFRSYYGRQILKTPVWNWMIAAYLFSGGLSAGSALLAAGADLTGRPRLRKVSRLGALASLLASMYFLIGDLGRPERFHHMLRVAKPSSPMSMGTWLLGGYGPGAGLAAVAELMPAWLRRTWLGRLVNRAARPAGLEAAAVAPGVASYTAVLLSQTAVPAWRDAHPYLPFVFTGSAAASGAGLGMLLAPVSESGPARRMAVTGAALEVVASRTMEHRLGLVAEAYTTGKAHRLRQWSEILTVGGAVGAVVSGRRQWAVAASGAALLAGSALQRFGVFEAGVQSTRDPKYVVVPQRKRLDEGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGL2</accession>
    <name>A0A132PGL2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acylphosphatase</fullName>
            <ecNumber evidence="3 4">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_25140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854173.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27460"/>
    <dbReference type="EnsemblBacteria" id="KWX21498">
        <property type="protein sequence ID" value="KWX21498"/>
        <property type="gene ID" value="AFM11_25140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2389"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="6">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="98" mass="10572" checksum="94538867931B316A" modified="2016-06-08" version="1">MTGPEPANPEVRLSAWVHGHVQGVGFRWWTRSRALELGLTGFASNRPDGRVHVVAQGPPDACERLLDLLQSGETPGAVDKVVADWSEPDAPMAGFGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGM6</accession>
    <name>A0A132PGM6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">smc</name>
        <name evidence="7" type="ORF">AFM11_25145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854176.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27465"/>
    <dbReference type="EnsemblBacteria" id="KWX21499">
        <property type="protein sequence ID" value="KWX21499"/>
        <property type="gene ID" value="AFM11_25145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2390"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="6">
        <location>
            <begin position="510"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="329"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="417"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="654"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1195" mass="129977" checksum="75C1F798A5A3C363" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH80</accession>
    <name>A0A132PH80_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_24615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853829.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23505"/>
    <dbReference type="EnsemblBacteria" id="KWX21695">
        <property type="protein sequence ID" value="KWX21695"/>
        <property type="gene ID" value="AFM11_24615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2284"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="332"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="364"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="576" mass="60384" checksum="5CDBD70473F3F4E7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH84</accession>
    <name>A0A132PH84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23865</name>
        <name evidence="4" type="ORF">AWC31_24280</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853869.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24280"/>
    <dbReference type="EnsemblBacteria" id="KWX21709">
        <property type="protein sequence ID" value="KWX21709"/>
        <property type="gene ID" value="AFM11_23865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15668">
        <property type="protein sequence ID" value="ORX15668"/>
        <property type="gene ID" value="AWC31_24280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2131"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453343" evidence="2">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX15668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="134" mass="14230" checksum="ABF1682DCAC1BD45" modified="2016-06-08" version="1">MIVVAVVVVVLAGFAVNRLHGIFASQDVVSTPSGSADEIVPFNPKHVVLEVFGPPGTVATVTYLDVDAQPQRADGVTLPWAYDATTTQPAVAVNISAQGDTDWIGCRIKIDDVVKDERTVNTLNAFTYCLDKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHK9</accession>
    <name>A0A132PHK9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_23505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853217.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21816">
        <property type="protein sequence ID" value="KWX21816"/>
        <property type="gene ID" value="AFM11_23505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2056"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004736">
        <property type="entry name" value="MHS_symport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00883">
        <property type="entry name" value="2A0106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="444" mass="47568" checksum="BC6FF7FFD2319B8C" modified="2016-06-08" version="1">MSELSHNPPAGRHSSIRKVIVASLIGTSLEWYDFFIYGTAAALVFNELFFPSFDPLVGTLLAFATYAVGFVARPLGGIVFGHYGDKIGRKNVLVATLLLMGIATMLVGLLPTHAAIGVWAPILLVLLRFLQGLGLGGEWGGAVLMTLESGDRTRRGLNASWPQVGVPIGLLLANGVLSLMGALTSDEAFLSWGWRVPFLLSGLLVVVGLWIRLTISESPLFTEVEETGAKSSAPIVEVLRRYPKHILLAIGARVGVDVAFYTFVLFVTTYIATYLELPEQYALNAVLIAAALQVVAIPFFGHLSDRFGRRPVMLIGAIGAAVWVFAFFALLDTGQFGLIVLAVIVALILHASLYGPQASFIAEMFPTKVRYTGASMGYQLAGILGGALAPIISVALLDRFGTSIVVSVYAVAMLLITIICVFIAPETSKIDLHAEDVPLSHARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI44</accession>
    <name>A0A132PI44_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853761.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21672">
        <property type="protein sequence ID" value="KWX21672"/>
        <property type="gene ID" value="AFM11_24475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2256"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="229" mass="23472" checksum="406983C597B7236B" modified="2016-06-08" version="1">MQIQGSVAFVTGANRGLGRHLAQQLVARGAKVYAAARNPETITLDGVIPVRIDITDPATIAAASEIARDTTLLVNNAGTASYNGLLEGPLDDIRAQMESHYFGTLAVTRAFAPHLIANAPGAVLNVASVLSWVHPAGIGAYSAAKAALWAQTDAVREELAAKNVAVTALHVGYMDTDMTAGVDAPKADPAQVAAAALDGVEAGLVEVLGDDLTRQVKAGLSADRGAVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI47</accession>
    <name>A0A132PI47_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Prokaryotic ubiquitin-like protein Pup</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Bacterial ubiquitin-like modifier</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pup</name>
        <name evidence="8" type="ORF">AFM11_22940</name>
        <name evidence="9" type="ORF">AWC31_08265</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prokaryotic ubiquitin-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003880265.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08265"/>
    <dbReference type="EnsemblBacteria" id="KWX22016">
        <property type="protein sequence ID" value="KWX22016"/>
        <property type="gene ID" value="AFM11_22940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10155">
        <property type="protein sequence ID" value="ORX10155"/>
        <property type="gene ID" value="AWC31_08265"/>
    </dbReference>
    <dbReference type="GeneID" id="29426676"/>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1941"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02106">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008515">
        <property type="entry name" value="Ubiquitin-like_Pup"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05639">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03687">
        <property type="entry name" value="pupylate_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="ARC ATPase binding" evidence="6">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="modified residue" description="Deamidated glutamine" evidence="6">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)" evidence="6">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX10155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="64" mass="6924" checksum="16E34C10BB4F2DF7" modified="2016-06-08" version="1">MAQEQTKRGGGGGEDDDLPGASAAGQERREKLAEETDDLLDEIDDVLEENAEDFVRAYVQKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI48</accession>
    <name>A0A132PI48_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="4">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_23030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08180"/>
    <dbReference type="EnsemblBacteria" id="KWX22029">
        <property type="protein sequence ID" value="KWX22029"/>
        <property type="gene ID" value="AFM11_23030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1957"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="285" mass="31104" checksum="A34242AAB6405D13" modified="2016-06-08" version="1">MAGWTTVPRTGPFAVGDRVQLTDAKGRHYTMVLNPGGEFHTHRGIIPFDEVIGLPEGSVVKSTSGDQFLVLRPLLVDYVMSMPRGAQVIYPKDAAQIVHEGDIFPGARVLEAGAGSGALTCSLLRAVGPEGRVTSYEVRDDHAVHAERNVTTFFGERPQNWDLVIGDVAEYTGPEMDRVVLDMLAPWEVLPAISQALVAGGVLMIYVATVTQLSRAVEALREQQCWTEPRAWESMQRGWHVVGLAVRPQHTMRGHTAFLISVRKLAPGAVAPMPLRRKRQLGGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI83</accession>
    <name>A0A132PI83_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="20" type="ORF">AFM11_22560</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852957.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08645"/>
    <dbReference type="EnsemblBacteria" id="KWX22045">
        <property type="protein sequence ID" value="KWX22045"/>
        <property type="gene ID" value="AFM11_22560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1862"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="53"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="457"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="17">
        <location>
            <begin position="678"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="634"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="674"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KWX22045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="723" mass="80931" checksum="95C44A9E6949BD27" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIF4</accession>
    <name>A0A132PIF4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21785</name>
        <name evidence="3" type="ORF">AWC31_04590</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852433.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04590"/>
    <dbReference type="EnsemblBacteria" id="KWX22130">
        <property type="protein sequence ID" value="KWX22130"/>
        <property type="gene ID" value="AFM11_21785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10569">
        <property type="protein sequence ID" value="ORX10569"/>
        <property type="gene ID" value="AWC31_04590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1705"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453054" evidence="1">
        <location>
            <begin position="28"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="368" mass="39996" checksum="1B564EA943478429" modified="2016-06-08" version="1">MSPRLGRLTVAIGLTFALVACGGSPTASNTNVGAAETAAKYQQYEGLKGQERRDRLVQDAKAEGGEVSLYTSMTADVAEAVTKAFTEQTGIRVKLYRAASETVLQRLLQEASANHPGADVVETNDREMSAIGGEGLAAPYTGERRDLVGEEGRFDDWTATRYNLFTPSWNTTKVPAGQQPKSWEDLADPKWDGQLAMELSDYDWYLTLYSYWQKKGKSDSEIDRLFADMANGAKVVKGHTVMGELLSAGQFAVAASNYSYLVQRVKDKGAPVAYEPFVQPVIARPQGAALMKSAAHPAAALLFVDWLLTEGQQVLVDMALTPAIEPEGLPDPLKGIEVIPVDVDKLVNEAQQWSERYSALLEKSAKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIS3</accession>
    <name>A0A132PIS3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NIPSNAP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21485</name>
        <name evidence="2" type="ORF">AWC31_04300</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852349.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04300"/>
    <dbReference type="EnsemblBacteria" id="KWX22087">
        <property type="protein sequence ID" value="KWX22087"/>
        <property type="gene ID" value="AFM11_21485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10528">
        <property type="protein sequence ID" value="ORX10528"/>
        <property type="gene ID" value="AWC31_04300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1645"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="234" mass="26874" checksum="4B4E42CF9B1ABAFC" modified="2016-06-08" version="1">MKKFYGHTLLYLHETIDLGVGRADQFTQAFSDVYQPMMEDLGARLFAIWETTPYNGHWPQVTIIWEIDAFADYARIGKAQAAGGSHEKPATQWATYLSEIGARGEGRIMYAGKYNRTLAELRQEGFGAGLVIQEIMQTKPGRQDDYIRELERLYVPWSERTGKRWLGSFITTFRFNEVIHYWALDGDWDCFENHYPSWKDSPPAEIVTWMSVAPALRDGWEDSILAALPPSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIX4</accession>
    <name>A0A132PIX4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_21825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852448.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04630"/>
    <dbReference type="EnsemblBacteria" id="KWX22137">
        <property type="protein sequence ID" value="KWX22137"/>
        <property type="gene ID" value="AFM11_21825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1713"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045623">
        <property type="entry name" value="LigXa_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19301">
        <property type="entry name" value="LigXa_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="428" mass="48099" checksum="19424762E4C3B568" modified="2016-06-08" version="1">MLRAEINELLTRTGPGTPMGELFRQYWMPALLAEELPEDDCPPVRVKLLSERMIAFRDSEGRYGLIDEFCAHRGASLWFGRNEEGGLRCPYHGWKYDVTGQAVEIPSEPENSTFCAHVKLTSYPLVKIGDVLWTYMGDPEKQPPLPEFEFALVPPEQTYTSKRWQECNWLQAFEGGIDSSHVSFLHSGGLKSDPLFKGTKGNEYNMGDLKPFFEVADSDGGLFVGARRNAEDDTYYWRITPWVMPCFTMVPPRGDHPVHGHFWIPIDDENCWAYSFDYHPVRALTATEVQAMKDGHGVHSENIPGTYRPAANKDNDYLIDREAQKRGDTYSGVKGIAMQDASLQESMGPIVDRTKEMLVSADSGIIKARQKLKRAAEALRDKGTTPPGVDPAHHRVRSAAVVLPRDASFVEACREDLSVREGVRQSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ52</accession>
    <name>A0A132PJ52_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">AFM11_21610</name>
        <name evidence="6" type="ORF">AWC31_04415</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852606.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04415"/>
    <dbReference type="EnsemblBacteria" id="KWX22217">
        <property type="protein sequence ID" value="KWX22217"/>
        <property type="gene ID" value="AFM11_21610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10682">
        <property type="protein sequence ID" value="ORX10682"/>
        <property type="gene ID" value="AWC31_04415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1670"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX10682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="377" mass="39567" checksum="7F0451881CF4B13F" modified="2016-06-08" version="1">MPAPPAPTLAPRRKTRQLMVGNVGIGSDHPIAVQSMCTTKTHDVNSTLQQIAELTASGCDIVRVACPRQEDADALAEIARHSQIPVIADIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVKEVAKAAGDAGIPIRIGVNAGSLDKRFMEKYGKATPEALVESALWEASLFEEHGFGDIKISVKHNDPVIMVAAYELLASKCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSKGIGDTIRVSLSAPPAEEVKVGNQILESLNLRPRGLEIVSCPSCGRAQVDVYTLANAVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPEAHIVETLIEEAMRLAEERGSDDASGSPVVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJC1</accession>
    <name>A0A132PJC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_20045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851890.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28470"/>
    <dbReference type="EnsemblBacteria" id="KWX22448">
        <property type="protein sequence ID" value="KWX22448"/>
        <property type="gene ID" value="AFM11_20045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1345"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="66"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="427"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="460"/>
            <end position="467"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="643" mass="72159" checksum="BC3A14FBC85F2B7D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJI4</accession>
    <name>A0A132PJI4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851935.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22491">
        <property type="protein sequence ID" value="KWX22491"/>
        <property type="gene ID" value="AFM11_20290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1392"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="134" mass="13710" checksum="4B67DDC6CFF0C452" modified="2016-06-08" version="1">MSIDRAALAAGTIRLASGISFLVDPLRANRLWGSPDKPDATAQLLLRSMGYRDALIGGLLVAAGLRGADTRGWFLASGGADAADLLGGLGVHGEMPRSQQIIGLGGAVVGIGVGLWGATRRRPKPASTGFPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJK7</accession>
    <name>A0A132PJK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852276.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06630"/>
    <dbReference type="EnsemblBacteria" id="KWX22377">
        <property type="protein sequence ID" value="KWX22377"/>
        <property type="gene ID" value="AFM11_21265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1599"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453350" evidence="1">
        <location>
            <begin position="26"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="172" mass="18452" checksum="FB92016DC7C4E862" modified="2016-06-08" version="1">MAAATALVFTFGFGAGLGFAGPVQAEPVMNGVYTYTQEGLEPQTWSIYPSCVPVVGDLREPLELAVACRLHVEASRGTSGGDARLADGQWQFITSKIEGMQCPDGSWAPITETYRFNDVTLSGTRSVSHNAVCGLAPSIHTVPFTLAYQKPLPLPVEAYPLDCEPWGLRLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJV2</accession>
    <name>A0A132PJV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851632.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15220"/>
    <dbReference type="EnsemblBacteria" id="KWX22618">
        <property type="protein sequence ID" value="KWX22618"/>
        <property type="gene ID" value="AFM11_19150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1164"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="177"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="346" mass="37848" checksum="EA79A4E040005F71" modified="2016-06-08" version="1">MSGATSFTEVPIVDISGLLSADRSEQGRVAAEIGKAAREVGFFYISGTGMPEALFDTMLSAVKEFFALPIEEKMRSYIGLSRCHRGYVPVGEEGLETGTPDLKEAFDTALDLPADDPDYLAYNPMLGPNTWPDVPGFAEAVTAYYHAVLAVGHRLLWAFAVALGEDPDTFAQHATKTPSQLRLIHYPYNPDAEDSQGIGAHTDYECFTLLKPTAPGLEVMNGAGQWIDVPPIPGTFVVNIGDMLELWTNGTFVATSHRVRRVKEERYSFPLFFNVDYYTEVKPLPQFVTEGMTTTRPALRAGEHLFAQTAQTFAYLRARIQRGELALPEGSVGLGTFGQQALHAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJX3</accession>
    <name>A0A132PJX3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851931.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11450"/>
    <dbReference type="EnsemblBacteria" id="KWX22487">
        <property type="protein sequence ID" value="KWX22487"/>
        <property type="gene ID" value="AFM11_20265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1387"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="305" mass="34759" checksum="7447A5B2EA6F2B0C" modified="2016-06-08" version="1">MAKSFTLVQLRYFTVVARLENMRAAAFELNVTQSTLSAAIHQLEREVGAQLFHRRSNRGLRLTAEGRRLLMGARTVLEDADQLYHSVRAEREELAGDLVAGIFSPIAPFLAPKILTAFEQHHPAIKLSFLEADQETLMRSLAEGTCETALMYDLGLGTDYEYRVLQRVPPHLLVAENHPRAAHPDVAVHLKEFEDEPFVLLDLKHSREYYLDIFKRLGLRPRIRHLVSGYETVRSYVSMGHGYSMLNWRLTRDVTYAGGRVIPLELADELPPIELVLVRMKGGRPTRKSIAFEEICIELQSEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK65</accession>
    <name>A0A132PK65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851782.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15685"/>
    <dbReference type="EnsemblBacteria" id="KWX22738">
        <property type="protein sequence ID" value="KWX22738"/>
        <property type="gene ID" value="AFM11_19620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1257"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026338">
        <property type="entry name" value="NDMA_methanol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04266">
        <property type="entry name" value="NDMA_methanol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="21"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="423" mass="46310" checksum="4ACB01FA8717E480" modified="2016-06-08" version="1">MAVELNQIWDFPIKEFHPFPRALLGVGAHDIIGVEAKSLGFKRTLLMTTGLRGSGIIEELTGKIEYQGVEVVLYDKVESNPKDYNVMEAAALYQQERCDSIISIGGGSSHDAAKGARVVIAHDGRNINEFEGFAKSTNKQNPPHIAVSTTAGTGSETSWAYVITDTSDMDHPHKWVGFDEATIVTLAIDDPLLYYSCPQHFTAYCGFDVLAHGSEPFVSRLDFAPSLGNALYSVELVAKHLREAVFEPRNLKAREGMMNAQYIAGQAFNSGGLGIVHSISHAVSAFFDSHHGLNNAIALPRVWEYNLPARYERYAQLATAMGVDTRNMTTVQAADAAVEAAIRLSQDVGIPDNFSQIRTDSYDKNRMNTGKYAGRGEVIKGDDKTVLAISEHIQDDWCTPGNPREVTVESMIPVVGHAINESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK79</accession>
    <name>A0A132PK79_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_17460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851046.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04980"/>
    <dbReference type="EnsemblBacteria" id="KWX22746">
        <property type="protein sequence ID" value="KWX22746"/>
        <property type="gene ID" value="AFM11_17460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.847"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="6">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="306" mass="33134" checksum="B110B189EEA8D3EA" modified="2016-06-08" version="1">MYDQPITNDPDAGADPGFRIDPVLARSWLLVNGAQYERFAPAARSRADIVVLDIEDAVAPKDKVAARDNVTRWLADGNSDWVRVNGFGTPWWADDLEMLTGTSVGGIMLAMVESVDHVTETAKRLPNIPIVALVETARGLERITEIAAAKGTFRLAFGIGDFRRDTGFGDNPATLAYARSRFTIAAKAAHLPSAIDGPTVGSSALKLSEATAVSAEFGMTGKICLTPDQCPTVNEGLSPSQDEISWAKEFFAEFQRDGGEIRNGSDLPRIARANKILDLAKAYGIHEPEYTDDPDHVPAPSDTYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK90</accession>
    <name>A0A132PK90_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein LpqH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851804.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15085"/>
    <dbReference type="EnsemblBacteria" id="KWX22723">
        <property type="protein sequence ID" value="KWX22723"/>
        <property type="gene ID" value="AFM11_18995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1133"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008691">
        <property type="entry name" value="LpqH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05481">
        <property type="entry name" value="Myco_19_kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453138" evidence="2">
        <location>
            <begin position="25"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="172" mass="16427" checksum="A89B5EB1BA089609" modified="2016-06-08" version="1">MKRGFLVAVGGAAIVAAGLSGCSSDEKGSDSSEASPTATASVSPSASVQAGDATATTGSGTARVVIDGKETPVEGSVVCATVAGNVSVTVGQGMSAVTATLSEGDQPTVSAVALGNIDGVSLGYTPGVPGGSAEATKDGNKYTIKGNATGADMANPMAGAVTKPFELEVTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKH0</accession>
    <name>A0A132PKH0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">AFM11_19550</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851770.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15620"/>
    <dbReference type="EnsemblBacteria" id="KWX22687">
        <property type="protein sequence ID" value="KWX22687"/>
        <property type="gene ID" value="AFM11_19550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1243"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="38"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX22687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="344" mass="35981" checksum="7642414C2CC8D743" modified="2016-06-08" version="1">MVNIGVVGATGQVGQVMRTLLEERNFPASSVRFFASARSEGKKLPFRGQEIEVENSETADPSGLDIALFSAGATMSRVQAPRFAEAGAVVVDNSSAWRKDPDVPLVVSEVNFARDAGRRPKGIIANPNCTTMAAMPVLKPLHDEAGLTRLIVSSYQAVSGSGLAGVDELASQARAVIDGVEQLVHDGSALEYPAPVKYVAPIAFNIVPLAGSLVDDGSGETDEDQKLRNESRKILGIPELLVSGTCVRVPVFTGHSLSINAEFAEPLSVSRATELLASAPGVKLVDVPTPLAAAGVDESLVGRIRQDPGVPDGRGLALFVSGDNLRKGAALNTIQIAELLAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKH9</accession>
    <name>A0A132PKH9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851779.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15675"/>
    <dbReference type="EnsemblBacteria" id="KWX22697">
        <property type="protein sequence ID" value="KWX22697"/>
        <property type="gene ID" value="AFM11_19605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1254"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="182" mass="20340" checksum="69DB254DC507DC91" modified="2016-06-08" version="1">MLDQETAQERALEAAEQLFYRRGIQAVGMDAVRTASGISLKRLYQLFPSKEELVLEFLRQRDSRWQRALVDHVEAQTPAERVTAVFDWLYNWFSEPDYRGCAFINSFGELGGVSPAVAEQARHHKRVFHDYLADLVEAAGRPRALGGQLALLAEGAITTAAIFGTPEPAHQAREAAQVLMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKI3</accession>
    <name>A0A132PKI3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851268.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12185"/>
    <dbReference type="EnsemblBacteria" id="KWX22848">
        <property type="protein sequence ID" value="KWX22848"/>
        <property type="gene ID" value="AFM11_18115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.980"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019910">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_4879"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03564">
        <property type="entry name" value="F420_MSMEG_4879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="301" mass="31710" checksum="72A831B3524EAA99" modified="2016-06-08" version="1">MHISRLVFPTGGLDTFVDDIVACEQAGFHGAWVPQIFGWDALTALAMAGGRTTSLRLGTAVLPIYPTHPVVLAQSAMTTQAAAGGRFTLGLGTSHRFVVENVWGMDFERPRHRMAEFLRIVVPAMAGADVEFRGEELSATTLRPLELPGIEPPDIVLAAMGPAMLRLAGAHADGTVTWMTGVRTLTEHIVPTIAAAAEHAQRPAPRVIAGLPVCVTDNPAAARDAARREFAAYNDVPSYRAMLDREGFTHAGDAALIGSADEVLDLIGEVAGAGATELCANIFGSPDERAATIEVLGRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKL3</accession>
    <name>A0A132PKL3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial proteasome activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_18685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bpa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851492.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22410"/>
    <dbReference type="EnsemblBacteria" id="KWX22552">
        <property type="protein sequence ID" value="KWX22552"/>
        <property type="gene ID" value="AFM11_18685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1074"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019695">
        <property type="entry name" value="Proteasome_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10759">
        <property type="entry name" value="DUF2587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="173" mass="18929" checksum="BD73A7B8C030AFDF" modified="2016-06-08" version="1">MTINPDDDNIEILTSAAGDNEAEADADGKSLTDLVEQPAKVMRIGTMIKQLLEEVRAAPLDDASRNRLREIHRTSIRELEEGLAPELREELERLTLPFTEDNTPSDAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLEQMRQGALPPGLQVPGGQRGGPSHPGTGQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKW3</accession>
    <name>A0A132PKW3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_16620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850687.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01190"/>
    <dbReference type="EnsemblBacteria" id="KWX22995">
        <property type="protein sequence ID" value="KWX22995"/>
        <property type="gene ID" value="AFM11_16620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.673"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="264" mass="28876" checksum="51B06F71C5777C86" modified="2016-06-08" version="1">MSRKLTVLAVDDEAPALDELAYLLGRHPDVAEVHTAADATSALRELNRHPIDAVFLDINMPGLSGIELAGVLTNFAHRPAVVFVTAHDDKAVAAFDVGAIDYLLKPIRQNRLDEAVRRVATAGETATPAQPDEPDDQDSAVIPAELGGITHLVQRDSIGWVEAEGDYARLHSATGAHLVRIPLSTLETRWRDHGFQRIHRSYLVSLRQVTGLRTAEGAVLVRLRANGASPAVELPVSRRQARELRDRLVRDPMRNLKPTGADDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL00</accession>
    <name>A0A132PL00_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_19515</name>
        <name evidence="9" type="ORF">AWC31_15600</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851764.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15600"/>
    <dbReference type="EnsemblBacteria" id="KWX22682">
        <property type="protein sequence ID" value="KWX22682"/>
        <property type="gene ID" value="AFM11_19515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17847">
        <property type="protein sequence ID" value="ORX17847"/>
        <property type="gene ID" value="AWC31_15600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1236"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="7">
        <location>
            <begin position="7"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX17847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="417" mass="43117" checksum="CC8F5D2EB75E26D9" modified="2016-06-08" version="1">MDTGTTAFMLCCIIGLTLMIPGLALFYGGMVSVKSSTNMMMMTFGAVAVVGLLWVLFGFSMVFGTSYSGFVGSFTEFAGMTNLTEPMTTIDGLPISLFSLFQALFAAITVALISGAVADRMKFGAWMIFAAVWAVLVYFPVAHWVFAFDGVVTENSVGGWIANKLHAIDFAGGTAVHINAGAAALAVAIVLGKSAMFGQLRKPHNVPLTLLGAGMLWAGWYAFNGGSALAAGNSAAIVMVTTFVATCAAVLAWLAVEKFKTGHVTGVGAASGAITGLVAITPACGAVTPIGAIFVGGIAGAVCVYAVGLKDKFGYDDSLDVVGVHLVGGVVGTLLIGFFASEGMPNAVNGLLYGGGIDQLWRQAVAAAAVMAYSFVVAYAIAFAIKKTMGIRISPDEEEKGIDAKFHRDSAYELEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL79</accession>
    <name>A0A132PL79_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein DivIVA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16950</name>
        <name evidence="4" type="ORF">AWC31_01520</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850811.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01520"/>
    <dbReference type="EnsemblBacteria" id="KWX23053">
        <property type="protein sequence ID" value="KWX23053"/>
        <property type="gene ID" value="AFM11_16950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13236">
        <property type="protein sequence ID" value="ORX13236"/>
        <property type="gene ID" value="AWC31_01520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.743"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX13236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="129" mass="13552" checksum="2196EB1545FDD48A" modified="2016-06-08" version="1">MTLILLYLVVLVLVATVLFGLGSVIFGRGETLPPLPRGTTATVLPASGVTSADVEALKFSQTVRGYKTSEVDWVLDRLGTELDALRGELAAVRAAYGIADEEVAEDGEADDVEVSATAGQIRTTTDEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL85</accession>
    <name>A0A132PL85_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAA_hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850928.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01840"/>
    <dbReference type="EnsemblBacteria" id="KWX23109">
        <property type="protein sequence ID" value="KWX23109"/>
        <property type="gene ID" value="AFM11_17275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.808"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="231" mass="25179" checksum="9446BB1A28859212" modified="2016-06-08" version="1">MTIPTAPTSNPVQILVAGQPTSLPVRRIYCVGRNYVDHIREMKEGDERDAPFFFQKPTDAVVGDGAAVSYPSATSDFQYEGELVIVIGEGGRDIPVEASVDHIFGFAVGIDLTRRDLQRELARAGRPWEAGKSFDQSAPVGTVTRMADLPASLVADGELSLWVNDELRQHCRFAQMIWKVPEIVSNLSAQYRLEFGDLIYTGTPAGVGPLVPGDRVRAAITGLHDLTITIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLW6</accession>
    <name>A0A132PLW6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsN</name>
        <name evidence="5" type="ORF">AFM11_16080</name>
        <name evidence="6" type="ORF">AWC31_16655</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850456.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16655"/>
    <dbReference type="EnsemblBacteria" id="KWX23326">
        <property type="protein sequence ID" value="KWX23326"/>
        <property type="gene ID" value="AFM11_16080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18029">
        <property type="protein sequence ID" value="ORX18029"/>
        <property type="gene ID" value="AWC31_16655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7341"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX18029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="101" mass="11748" checksum="2E9256C334A1C176" modified="2016-06-08" version="1">MAKVSKIVKNEQRRKLVERYAERRAELKEIIRNPASTREQRAAAVSALQRLPRDSSPVRLRNRDSVDGRPRGHLRKFGLSRVRVRELAHRGELPGVRKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMG6</accession>
    <name>A0A132PMG6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849859.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23493">
        <property type="protein sequence ID" value="KWX23493"/>
        <property type="gene ID" value="AFM11_14535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7015"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453456" evidence="2">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="109" mass="11159" checksum="0A299288F8342BAE" modified="2016-06-08" version="1">MNIKQAVCASAIVAGVGLAGAMGTGIGTASADPCNRPPNPSFCNGPGGPAPNNPPGPRGGPGAGPGQRGLEDGRIDHQPFIYNGQNVNPVFDHDRNAWGFWFLGVWIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN06</accession>
    <name>A0A132PN06_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850038.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17760"/>
    <dbReference type="EnsemblBacteria" id="KWX23577">
        <property type="protein sequence ID" value="KWX23577"/>
        <property type="gene ID" value="AFM11_15080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7127"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="PTHR37489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="405" mass="44695" checksum="46674F7A50B58F15" modified="2016-06-08" version="1">MTFDTFTSRRPRTPAEIRALDATRPLAVELAAKVAAWLESLSSEQRTRATFGSPGSSENERLLWFYTPTDHGGLPLVDQRPAQHRLVMQILATGLSEPGYVTLVTVMGMENVLDRLEGWSMTFERDRGRDPGMYYVSVFGSPDDRLWGWRFGGHHVSVNQLIADGRVVSTTPLFLGADPAAAPLLGSVLQPLVSVQDVALDLMRSFDRDQRTRALINPRAVSDLVGANRSLVSEGDQRLPLPDVFRGRFTDSQVATQLDEVNEAMQAGSGYSAEDDAQVALTGVPKGLPAAAMTATQRDALRILLDLYFTRAAEPIAESYRVRYQAADQFDALHVAWAGAIKAGEPHYYRIQGPGILIEYDNTQRRANHVHAVWRDPTGDFGVDTLAHHHHTAHGALRAHRPNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN07</accession>
    <name>A0A132PN07_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">deoC</name>
        <name evidence="4" type="ORF">AFM11_13100</name>
        <name evidence="5" type="ORF">AWC31_03385</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849226.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03385"/>
    <dbReference type="EnsemblBacteria" id="KWX23719">
        <property type="protein sequence ID" value="KWX23719"/>
        <property type="gene ID" value="AFM11_13100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11178">
        <property type="protein sequence ID" value="ORX11178"/>
        <property type="gene ID" value="AWC31_03385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6713"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX11178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="225" mass="22180" checksum="EF641B47F257B6EC" modified="2016-06-08" version="1">MSRYTRGQVAALVDHTLLKPEATAADVAALVAEAADLAVFSVCVSPPMVAGAAKECPAGLAVAAVAGFPSGKHLPEIKAAEARSAVAAGASEIDMVIDVGAALSGDLAAVAADVAAVRAAVADATLKVIVESAALLEFSGQALLVDVCRAAEQAGADFVKTSTGFHPSGGASVQAVEIMARTVGERLGVKASGGIRTAEQAVAMLDAGATRLGLSGTRAVLDGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN26</accession>
    <name>A0A132PN26_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolyl oligopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03510"/>
    <dbReference type="EnsemblBacteria" id="KWX23740">
        <property type="protein sequence ID" value="KWX23740"/>
        <property type="gene ID" value="AFM11_13225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6738"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="461"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="664" mass="74067" checksum="9F3BC2FF1437AF24" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN67</accession>
    <name>A0A132PN67_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="17">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">murB</name>
        <name evidence="19" type="ORF">AFM11_13075</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="17"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849211.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03360"/>
    <dbReference type="EnsemblBacteria" id="KWX23714">
        <property type="protein sequence ID" value="KWX23714"/>
        <property type="gene ID" value="AFM11_13075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6708"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 17" id="KW-0132">Cell division</keyword>
    <keyword evidence="12 17" id="KW-0133">Cell shape</keyword>
    <keyword evidence="16 17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0274">FAD</keyword>
    <keyword evidence="9 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 17" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="25"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KWX23714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="355" mass="37117" checksum="6DC4BF883021F39C" modified="2016-06-08" version="1">MVSSHVAGVEVAESVPLAPLTTLRVGPVARRVLTCTSTEQLVGVLRALDLDDESVLVLAGGSNVVLADDATDLTVVRVANTEITVDGNLVRAEAGAVFDDVVVTALAHGLGGLECLSGIPGSAGATPVQNVGAYGAEVADTISRVRLLDRRTGEDRWARPEELRFGYRTSVLKHSDAVIVLEVEFALDPDGRSAPLRYRELATALGAEPGERADPLAVRGAVLRLRGSKGMVLDAEDHDTWSVGSFFTNPVVSQPEFDRLRAAVDGPVPNYRAPDGVKLAAGWLVEHAGFGKGFPGDGAAARLSTKHALALTNRGQATTADVIALARTVQAGVREAFGIELTPEPILIGCSLSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNA2</accession>
    <name>A0A132PNA2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation:proton antiporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Monovalent cation/H+ antiporter subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_13445</name>
        <name evidence="8" type="ORF">AWC31_03730</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849383.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03730"/>
    <dbReference type="EnsemblBacteria" id="KWX23773">
        <property type="protein sequence ID" value="KWX23773"/>
        <property type="gene ID" value="AFM11_13445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11234">
        <property type="protein sequence ID" value="ORX11234"/>
        <property type="gene ID" value="AWC31_03730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6783"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX11234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="152" mass="15877" checksum="C5D41795C56DA6F9" modified="2016-06-08" version="1">MTTFLVPLILIGGLTSAGVYLLLERNLTRMLLGLLLIGNAVNLLILTAGGPGGNPPIRDRGSNGATTTADPLAQGMILTAIVISMGIAAFVLALAYRSYRLTTAEEVTNDPEDTRVSQLSAAEEDVIPLPDASRDTDAPDELDALPGFEGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNN9</accession>
    <name>A0A132PNN9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_11320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848167.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30575"/>
    <dbReference type="EnsemblBacteria" id="KWX23959">
        <property type="protein sequence ID" value="KWX23959"/>
        <property type="gene ID" value="AFM11_11320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6341"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004707">
        <property type="entry name" value="MmpL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00833">
        <property type="entry name" value="actII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="843"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="879"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="909"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="936"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="213"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1003" mass="106410" checksum="BA9A24CB51C05A64" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNS7</accession>
    <name>A0A132PNS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849543.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23847">
        <property type="protein sequence ID" value="KWX23847"/>
        <property type="gene ID" value="AFM11_13895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6875"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="218" mass="24000" checksum="AE87A2F761DA187F" modified="2016-06-08" version="1">MPVPVERGKHRRSLLRDQAYVSIRDAIVNGTLAPGEKLRDPELEEWLGISRTPIREALARLESAGLVHTTPGRSTVVSAIDRTAVLNAQSVAAAMHALAIRTAVPLMDESHFDTMAQANKRFAQALSRGDAEAAMRGDDEFHSVAVRACRNDVIEQVLEQVTPALRRLEYLRFSSLAGRDSIAQHKEIITLCRKNDAEAAAVATERNWQTLSQVVDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNU5</accession>
    <name>A0A132PNU5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fur family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11240</name>
        <name evidence="2" type="ORF">AWC31_30655</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848124.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23944">
        <property type="protein sequence ID" value="KWX23944"/>
        <property type="gene ID" value="AFM11_11240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12677">
        <property type="protein sequence ID" value="ORX12677"/>
        <property type="gene ID" value="AWC31_30655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6325"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX12677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="76" mass="8882" checksum="6C71E2C13065E84D" modified="2016-06-08" version="1">MPDSAPAERLRQNLLSALESSKKPMSTAQLRDHIHEHFREPVVIEAVYRNLTVLERRGDVRRRKLPGRDAHWTRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP06</accession>
    <name>A0A132PP06_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_11155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848071.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30745"/>
    <dbReference type="EnsemblBacteria" id="KWX23927">
        <property type="protein sequence ID" value="KWX23927"/>
        <property type="gene ID" value="AFM11_11155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6308"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="12"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="651" mass="67068" checksum="E6251C717A22E05B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP10</accession>
    <name>A0A132PP10_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848541.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09985"/>
    <dbReference type="EnsemblBacteria" id="KWX24076">
        <property type="protein sequence ID" value="KWX24076"/>
        <property type="gene ID" value="AFM11_11990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6477"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="17673" checksum="DDBB37B83C55172E" modified="2016-06-08" version="1">MTYPREELRALVREVVREAVAGLKTAPVRSEPTPPPPQTVAEQMGLEPTGPRAVDGRNRTEEVRLANDKDLDSFVRKLLRLFESPKTRADLKAGRLSFRLVGAPRTPGGPVTHRIDSGAVTERHIADMAGGTLVLGRRAVLTPLAREKARALGITIEKERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP13</accession>
    <name>A0A132PP13_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848476.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30170"/>
    <dbReference type="EnsemblBacteria" id="KWX24055">
        <property type="protein sequence ID" value="KWX24055"/>
        <property type="gene ID" value="AFM11_11880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6455"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="53"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="412" mass="43069" checksum="F762EB449646C778" modified="2016-06-08" version="1">MTVVLRAARWADVEAAQVCTPAVIVVDGNRITAVNPPELPSDSTVIDLGDVTLLPGLMDMELNLLIGGPGGPEGLPTPMHGVQDDPPYRTLRGAVNARTTLDAGFTTVRNLGLMVKTGGYLLDVALQRAIDQGWHAGPRIYPAGHAVTPYGGHLDPTVFQRLAPGIMPLSVAEGIANGVPDVIACVRYQIRHGAKLIKVSASGGVMSHSTAPGAQQYSDAEFAAIADEAHRAGVRVAAHAVGDTAIQACIRAGIDCIEHGFLASDETIQMMVDHGTFLVSTTYLTDAMAIDRIAPELRKKALDVFPRAKAMLPKAIAAGVRIACGTDAPAIPHSQNAKELCALVERGMTPMQAIRAATVVAAELIDADDELGRLAPGYLADIIAVPGDPSADISTTLDVSFVMKDGVVHKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP40</accession>
    <name>A0A132PP40_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_12135</name>
        <name evidence="9" type="ORF">AWC31_09840</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848612.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09840"/>
    <dbReference type="EnsemblBacteria" id="KWX24101">
        <property type="protein sequence ID" value="KWX24101"/>
        <property type="gene ID" value="AFM11_12135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09235">
        <property type="protein sequence ID" value="ORX09235"/>
        <property type="gene ID" value="AWC31_09840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6506"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX09235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="379" mass="39814" checksum="D6B94539B497AF72" modified="2016-06-08" version="1">MLSDSVADESVTPLVRKTAAWSWRLLVILGAVVALLWLVKRLELLVVPVALATMVTALLLPAVDFMDRRGAPRGSAVALVLLAGIAIVGGILTFVVSQFIEGAPDLVEQMTRSIDGVRNWLIEGPLHLSREQIDQAGNTAIEALQRNQEQLTTGALSTAGTLTELVTGALLMLFTLIFLLQGGRNIFAFVTKIFPDHVRERVRDAGRAGFHSLVGYVRATFLVALVDAVGIGTGLAIMGIPLALPLASLVFLGAFVPLVGAVVAGFFAVVVALLSKGFVYALITLGLIIAVQQLEGHVLQPLVMGRAVSIHPLAVVLAIAGGGVLAGIVGALLAVPAVAFLNSSARVLLARDPAAEEARQETEGETILEAPSDDLSERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPS4</accession>
    <name>A0A132PPS4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Competence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_09410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847083.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05815"/>
    <dbReference type="EnsemblBacteria" id="KWX24207">
        <property type="protein sequence ID" value="KWX24207"/>
        <property type="gene ID" value="AFM11_09410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5919"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="219"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="511" mass="51749" checksum="D0215F92038C4284" modified="2016-06-08" version="1">MTSPPPTATDGEDLDLRLFPAALTAWLVTAAGILWYVAGSVIALVAATLLTAAAARVGGAVRARTAAVLAVAIVGVGFAAAIGMRVYQVRHHPVVDRYGTTTEVTVTPSETPRVVKGGRLMFRGELSALGSQESSGRVLVFAPVAGYSDAAPGRSARFRAAIARPDRLDLTVAVVSATGQPSIGDASAVQRGAQHVRSDFADAARAALPADQAAMLPALVLGDTATVGAQTTAQFRAAGLTHLTAVSGANVTIVCGALLLTASLVGPRLAVVLAALGLIGFVVVVQPSASVLRAAVMGAVTLLAVLTHRRRRAVPALAASVLVLMIGAPELAVDAGFALSVCATAGIVVIAPVWSRRLEARGWPRPLAAAVSVAVVAQLVTAPLVAGISGTFSVVAVAANLAVAAVIPPITVLGTAAAAMASVWPAGAQLLIRFTGPELWWLLSVARWASSVPGSTVPTPSGFAGVVSVAAVGIALSVLWRLGWARRWMGRSLAVLAFGLLAWTLAGALQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPU5</accession>
    <name>A0A132PPU5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847355.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05310"/>
    <dbReference type="EnsemblBacteria" id="KWX24294">
        <property type="protein sequence ID" value="KWX24294"/>
        <property type="gene ID" value="AFM11_09915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6019"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453478" evidence="1">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="267" mass="27651" checksum="87E5AFD7EF7C77B6" modified="2016-06-08" version="1">MNGFVLVLIILVIAAIAFAVYSSSKANGRSAETLADAKADARRLIERLGGQVLNLTGSDDASKQALADASERYTAASSQIDQATTVKQAELAKESAIEGLYYVRAARTAMGMDPGPELESLAGQRTAGAVTEDRRINFEGREIEASPTPSQRTPNYYPGGRVAGRPVPAGWYSEPWWKPALIAGAWGLGSVLLFDALFSGMHGVDYGAQGFESGYGDGYSDGFAAGQDSGMDGGGDSAGDWGGMDTGGWDGGGDFGGGDFGGDFGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPV9</accession>
    <name>A0A132PPV9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847485.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24333">
        <property type="protein sequence ID" value="KWX24333"/>
        <property type="gene ID" value="AFM11_10155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6067"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="284"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="501" mass="54602" checksum="04545B5F56BB09B1" modified="2016-06-08" version="1">MREHDVRSLRSAEEFPRSQHLAWKIAEVAADPVPVLPETEAMVLNRIIDNAAVSAASVLRRPVTVAREQALSHRRRQGAAVFGVDSTVSAEWAAWANGVAVRELDFHDTFLAADYSHPGDNIPALVAVAQQLGVRGADLIRGIATAYEVQIDLTKGICLHEHKIDHVAHLGPSVAAGLGTMLRLDPETIYAAIGQALHLTTATRQSRKGLISSWKAFAPAWAGKVAIEAVDRAMRGEGSPAPIWEGEDGVIAWLLGGPEHTYRVPLPAAGEPKRAILDSYTKEHSAEYQSQAPIDLARRMRDRIGDLDQIASIVLHTSNHTHVVIGTGSNDPQKFDPAASRETLDHSVMYIFAVALQDGTWHHERSYAPERAHRPDTVELWKKISTVEDAEWTRRYHAADPAEKAFGAKAVVTLKNGDTIVDELAVADAHPLGARPFERPQYIAKFTELADGMVETAEQQRFLAAVDGLAAIKPGGLDALNVRVDQRVLDKAPSVPSGIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ53</accession>
    <name>A0A132PQ53_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase</fullName>
            <ecNumber evidence="6">1.13.11.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-carboxyethylcatechol 2,3-dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mhpB</name>
        <name evidence="8" type="ORF">AFM11_10925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25054"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:58642"/>
            <dbReference type="ChEBI" id="CHEBI:66888"/>
            <dbReference type="EC" id="1.13.11.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46951"/>
            <dbReference type="ChEBI" id="CHEBI:66887"/>
            <dbReference type="EC" id="1.13.11.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Aromatic compound metabolism; 3-phenylpropanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the LigB/MhpB extradiol dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.16" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19440"/>
    <dbReference type="EnsemblBacteria" id="KWX24459">
        <property type="protein sequence ID" value="KWX24459"/>
        <property type="gene ID" value="AFM11_10925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6224"/>
    <dbReference type="UniPathway" id="UPA00714"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047070">
        <property type="term" value="F:3-carboxyethylcatechol 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019380">
        <property type="term" value="P:3-phenylpropionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01653">
        <property type="entry name" value="MhpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023789">
        <property type="entry name" value="DHPP/DHXA_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="6 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="7">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="306" mass="32292" checksum="F54905A77ED09055" modified="2016-06-08" version="1">MSHSPLLNLPGPSAELLDEITTALDGARKFVADFDPELVVTFSPDHYNGFFYRLMPPFCIGTAASGVGDYGTHAGPLNVDADIADQCARAVWESGVDIAISSSMDVDHGTVQPLQELFGDATARPIVPIFINSVATPLGPLARSRALGAAVGSYLATLNKRVLVLGSGGLSHDPPVPTLATAPPAALDRIVHGVPMTPEQRMARQAAVSQAAHDFAHGDSSLRPLNPDWDHSLLEILDEGRLAELDGWSNEFIAGEGGNSAHEIRTWVAAFAALAANGPYRTADHFYRAAPELIAGFAIRTAVSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ60</accession>
    <name>A0A132PQ60_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_10660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847735.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19175"/>
    <dbReference type="EnsemblBacteria" id="KWX24414">
        <property type="protein sequence ID" value="KWX24414"/>
        <property type="gene ID" value="AFM11_10660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6172"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="5">
        <location>
            <begin position="165"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="272" mass="27271" checksum="DB135330F38F5DB5" modified="2016-06-08" version="1">MRVGFIGLGSQGAPMARRIVEGGYETTLWARRPASVEPFADTAAKVAGSPAELAAASDLVCLCVVGDDDVRQVLGGENGVLAGLARGGIIAIHSTVHPDTCAEISEQAAAQGISVIDAPVSGGEPAATAGTLLVMVGGEAEVVERARPVFATYADPIVHLGGVSAGQVAKILNNLLFSANLGAAMSALELGEALGVPRSALCEVITRGSATSKALNSIAMFGGTLDNLAPIAGALLQKDCRHAASLADTASAPQGAVFDAADAALALMNHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ85</accession>
    <name>A0A132PQ85_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847963.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24498">
        <property type="protein sequence ID" value="KWX24498"/>
        <property type="gene ID" value="AFM11_10515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6143"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="152" mass="16553" checksum="4BC62F8E0ADB11C3" modified="2016-06-08" version="1">MVGLGAAPAGADPGSWGINGTFATSVNGDWAKVNERYEDQPSERQNWTVTTECISPTDCAGTVTSDQGWSAPIYTVNGLYYVKRSVPEWRFCADGTPIEGLQVYKLYPVGFDGHVDLSSNEYTGEQQTTGPSGSCGRNQWPAIRAPFYMKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQB5</accession>
    <name>A0A132PQB5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847887.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24464">
        <property type="protein sequence ID" value="KWX24464"/>
        <property type="gene ID" value="AFM11_10960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6232"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="468" mass="48961" checksum="D1C8156976A5BDB1" modified="2016-06-08" version="1">MAALIATRQVSSREIVTTHLERIAEANPQINAIVTLLADDALRAADAADAAVKRDDPLGPLHGVPFTVKDCLDTAGVTTQSGSRIFAEFVPDADATAVRRMKAAGGVLLAKTNLPEFSSSTETDNLVTGRTNNPWNLNRTPGGSSGGDSAAIAAGMSPLGIGSDVAISVRGPAAFTGIAGLKATHGRIPFTGHFAPTTSAWWHVGPMARTVGDVALTYSILSGPDGIDGYAVYANHFDTGNTRIPGRALRVGWVSDEAFGPVDPEITAAVESAAARLAGLGCRVEQVGVPFLKQAAAPTALTTFVYGELVPYVKTLVAGRESDLSPAGSDILAVQDPTLEQLRVARRATETLRSAFGGYFADYDVLLCPVNPVTAPPHGAQEFVIDGATVPWTHVMTATAPFNLTGLPALSVPYSISSENLPINIQLVSAWFDESTILRLGAMLERSGGLGPRRPPITAEPIPMRPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQV3</accession>
    <name>A0A132PQV3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_10705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847759.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19220"/>
    <dbReference type="EnsemblBacteria" id="KWX24422">
        <property type="protein sequence ID" value="KWX24422"/>
        <property type="gene ID" value="AFM11_10705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6181"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="134"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="248"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="433" mass="48634" checksum="AC03E906393B3DCB" modified="2016-06-08" version="1">MAWDFETDAEYQQVLDWADDFVRDRVEPLDLVWPHQQFTPLEGKRREAITPLKDEVRQRGLWATHLGPELGGQGYGQLKLALLNEILGRSQWAPIVFGCQAPDTGNAEIIAHYGTDEQKQRYLRPLLDGELFSCYSMTEPHAGADPTLFTTRAVRDGDDWVINGWKFFSSNAATASFLIVMVVTNPDVSAYQGMSMFLVPTDTPGVKIVRNVGLYGERDDEGSHALIHYDNVRVPNEALLGGEGQAFVIAQTRLGGGRIHHAMRTIGLARKALDMMCERALSRETQGSRLSDKQFVQGYIADSYAQLLQFRLMVLYTAWEIDKYNDYKKVRKDIAAVKVVMPTVLHDIAWRAMQVHGALGVTNEMPFLGMVTGAAVMGLADGPTEVHKTTVARQVLRDYEPTDDTWPTEWIPRKREAARARFADYLEAEVGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR00</accession>
    <name>A0A132PR00_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_08070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846268.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24627">
        <property type="protein sequence ID" value="KWX24627"/>
        <property type="gene ID" value="AFM11_08070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5464"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453519" evidence="3">
        <location>
            <begin position="41"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylas" evidence="4">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="472" mass="46437" checksum="C227240D294DC00E" modified="2016-06-08" version="1">MSGRHRKPTSSSSAKNVAKIAFTGAVLGGGSLAMAGQAMAATDGEWDQVARCESGGNWAINTGNGYHGGLQFSPSTWSSHGGGEYAPAAYMATKEEQIAVAERVLASQGKGAWPTCGRGLSGATPRNVVAEPAPAPLDAPAVNGQLPPPPAPFAPPPPPAPVDMLAAPAPMPQAPPPAPLPEPLPPAPAPEALPPAPAPEALPPAPAPAPEALPPAPAPVAPAPVDVPPPPPPAPEAQIVDAALQVAPAPLDAPLPADVPPPPAPPAPPAPPVDVVAAPAPPAPENWDQAPAPVDQPQTWALHAGAPLPLEPALPAPPAPPAPAPAPAPVAAPAPDPLAPLNGVDIPQPAFDVANQVVTNGTPLPPEGVPHLASPENLPPGTTDSPAQIPGQGPNMTYLREIWHAIQTQDISGKDALLALTQRPLTSAPPGGQAANLPVGTPPPADPAAPAPAPAPVGAPAPAAPAPVPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR17</accession>
    <name>A0A132PR17_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846335.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00120"/>
    <dbReference type="EnsemblBacteria" id="KWX24647">
        <property type="protein sequence ID" value="KWX24647"/>
        <property type="gene ID" value="AFM11_08195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5490"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="146" mass="15803" checksum="61BC14F59C8CE669" modified="2016-06-08" version="1">MADISAFADVLSRDQGLCVLSTLRRDGGIQSSVVNAGVMAHPQNAEPVVALVAIGGSLKLRHLRADPRATVVARAGWQWVTVEGTAEIIGPDDSDVDPETLRVLLRNIFQAAGGTHDDWDTYDRVMREERRAAVLITPTRVYSNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR47</accession>
    <name>A0A132PR47_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_08355</name>
        <name evidence="6" type="ORF">AWC31_00245</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000001">
        <property type="protein sequence ID" value="ORX19328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846424.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00245"/>
    <dbReference type="EnsemblBacteria" id="KWX24677">
        <property type="protein sequence ID" value="KWX24677"/>
        <property type="gene ID" value="AFM11_08355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19328">
        <property type="protein sequence ID" value="ORX19328"/>
        <property type="gene ID" value="AWC31_00245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5522"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX19328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="199" mass="21997" checksum="C7F9C968A6673F05" modified="2016-06-08" version="1">MNSAATAVEADKSAFRLRLLDALEASIIEDGYQKTTVADIVRRARTSRRTFYEHFADREECFVALLTNANAEQVRQISAAVDPHAPWRDQVRQAIEAWIASGEAHPELMLSWIRDVPSLGTSARALQREAMENFIAMVQTISDTEEFHAAGVQVSRQRVIMVLGGLRELTAITVESGGRMSDITEEAVDASIALLEPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRD3</accession>
    <name>A0A132PRD3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bromoperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846875.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13100"/>
    <dbReference type="EnsemblBacteria" id="KWX24824">
        <property type="protein sequence ID" value="KWX24824"/>
        <property type="gene ID" value="AFM11_09270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5702"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="276" mass="30418" checksum="120683CC467FFDC1" modified="2016-06-08" version="1">MSVARYPERVEDTAILELAYEDQGSGDPVLFIAGQGGVGRTWALHQVPAFRSVGYRVITFDNRGVGATAHCDGFTTETMVADTAELIERVVGAPVRIVAVSMGSFIAQELMLARPELVTQAALLATRGRHDRTREFFRRAEEDLVRSEVRLPPTYEAKLRLLENFSPKTLNDDRLSGDWIDTFTMWPTKSTPGMRAQYDVAPQGDRLPAYRSIKTPVLVIGFADDLVMPPHLGAEVAAALPNGQYREIPDAGHLGFLERPEAVNSAILDFFDRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRG0</accession>
    <name>A0A132PRG0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08970</name>
        <name evidence="2" type="ORF">AWC31_13400</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846711.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13400"/>
    <dbReference type="EnsemblBacteria" id="KWX24777">
        <property type="protein sequence ID" value="KWX24777"/>
        <property type="gene ID" value="AFM11_08970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18313">
        <property type="protein sequence ID" value="ORX18313"/>
        <property type="gene ID" value="AWC31_13400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5644"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="161" mass="18008" checksum="1F6490F75E3D39CE" modified="2016-06-08" version="1">MRSKVAGLLIGLLAVAFVALSGAGGVLYWNRVQQHGQQATRAELAPLAADQIPKMFGYDYQTVERSLIETYPLLTPDFRQKFEEDATKTVIPEARKRQLVVQINVVGVGVMAAQRESGSVLVYMNRTVTDQSRQPLYDGSRLRVEYRKVDGKWLIDAINPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRI2</accession>
    <name>A0A132PRI2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_08225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846347.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24652">
        <property type="protein sequence ID" value="KWX24652"/>
        <property type="gene ID" value="AFM11_08225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5496"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="254" mass="27603" checksum="CA7FB575439B81B7" modified="2016-06-08" version="1">MSVRDQGSIVMSGDADSDASDATPDLVTLRRSQILCSAVRVVARDGADKARLKDIATEAGVSLGLVQHYFRNRQELMEQTFQVMMSVSLDAWHRLTATEPDPLVQLFAGLRLHVTGTVTFTDRWGFWMELWASARRDQAIAEIAHQVYARWTEPFRTAIAALDRAGLVQANGAHEHIALVLMALTDGLAVRSLVDPTAVTAEDMYERMTDTAGTLLGISAEDAAAASDRARSVVSAGTFTESLTPELIARVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRU2</accession>
    <name>A0A132PRU2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_06175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845220.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29500"/>
    <dbReference type="EnsemblBacteria" id="KWX25015">
        <property type="protein sequence ID" value="KWX25015"/>
        <property type="gene ID" value="AFM11_06175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4427"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="272"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="515" mass="54636" checksum="448BBD620BF966F8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS58</accession>
    <name>A0A132PS58_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="7" type="ORF">AFM11_06870</name>
        <name evidence="8" type="ORF">AWC31_28780</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845475.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28780"/>
    <dbReference type="EnsemblBacteria" id="KWX25135">
        <property type="protein sequence ID" value="KWX25135"/>
        <property type="gene ID" value="AFM11_06870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13789">
        <property type="protein sequence ID" value="ORX13789"/>
        <property type="gene ID" value="AWC31_28780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4573"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX13789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="202" mass="22131" checksum="8C47C7DE86D85A7A" modified="2016-06-08" version="1">MSRRAKVERKTKESDIVVELDLDGTGVVDIDTGVPFFDHMLTSLGSHASFDLTVHAKGDIEIEGHHTVEDTAIVLGQALGEALGDKKGIRRFGDAFIPMDETLAHAAVDVSGRPYFVHTGEPEFMVEFTIAGSSAPYHTVINRHVFESLAFNARIALHVRTLYGRDPHHITEAQYKAVARALRQAVEFDPRVTGVPSTKGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS61</accession>
    <name>A0A132PS61_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpB</name>
        <name evidence="14" type="ORF">AFM11_06950</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845512.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28700"/>
    <dbReference type="EnsemblBacteria" id="KWX25150">
        <property type="protein sequence ID" value="KWX25150"/>
        <property type="gene ID" value="AFM11_06950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4589"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="75"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX25150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="420" mass="44461" checksum="5A0FEB3E717A2563" modified="2016-06-08" version="1">MADLAGPELPRSSAGVAERTVHDPDNRGHFGSYGGRLVPEALMAVIEEVTAAYEKARGDQAFLDELDRLQRHYSGRPSPLYEATRLSEHAGGARLFLKREDLNHTGSHKINNVLGQALLAKQMGKTRVIAETGAGQHGVATATACALLGLECVIYMGAVDTARQALNVARMRLLGATVVAVQAGSKTLKDAINEAFRDWVTNADETYYCFGTAAGPHPFPLMVRDFQRVIGLEVRAQIQEQAGRLPDAVTACVGGGSNAIGVFHAFIDDPGVRLIGYEAAGDGVETGRHAATFTGGTPGAFQGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAYLKDIGRAEYRPVTDSEAMDAFSLLCRTEGIIPAIESAHALGGALKLGQELGSGAIIVVNLSGRGDKDVETAAKWFGLLDEGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS66</accession>
    <name>A0A132PS66_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_07225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845679.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17490"/>
    <dbReference type="EnsemblBacteria" id="KWX25198">
        <property type="protein sequence ID" value="KWX25198"/>
        <property type="gene ID" value="AFM11_07225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4645"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="353" mass="37778" checksum="F4D49AAEBFC6DC4B" modified="2016-06-08" version="1">MADDDLEFSRELLQELLWAYGPCGQEDAVREVCRRELEPFADETWVDAAGNLIGLIRGEHGSPPARVMAHMDELSMLVKRVEQDGTLRLTPLGTMYPANFGLGPVAVLGAQDQFCGVLSLGSEHTTQESQRIWATKPDQGDKALDWPDVYVFTGRTPDELTGAGIGPGTRVCIHRSKRTLIDVGGFLGGYFMDDRAAVTALLQAARALGEPGQRPAGDVYMVFTTAEEVGGVGALHACRTLPGDLTLALEVGPTEAEYDTTIEGGPIVAYSDAQCVYDKDVADRLMEIAAKLGLSPQAAVLGAFESDASHAKASGLSPRAGLLCLPTLSTHGYEVISRDAIPAMTDVLVEFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSI0</accession>
    <name>A0A132PSI0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 12">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpE</name>
        <name evidence="15" type="ORF">AFM11_06935</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 12"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845503.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28715"/>
    <dbReference type="EnsemblBacteria" id="KWX25147">
        <property type="protein sequence ID" value="KWX25147"/>
        <property type="gene ID" value="AFM11_06935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4586"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="14">
        <location>
            <begin position="40"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="13">
        <location>
            <begin position="238"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX25147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="513" mass="54886" checksum="D3E877EDF79D619F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSS5</accession>
    <name>A0A132PSS5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845792.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25237">
        <property type="protein sequence ID" value="KWX25237"/>
        <property type="gene ID" value="AFM11_05675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4325"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021315">
        <property type="entry name" value="Gap/Sap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11139">
        <property type="entry name" value="SfLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="245" mass="25018" checksum="42FF2C965878FB92" modified="2016-06-08" version="1">MWSTVLVMAAVAGTDPLRIGVVAYMLSRRHPARLLLPFVVVGFTVNVVVGAVVVFVLRETAAGGATIPPAVEIGIGVAALVIAALSATGVLERLADRIRGRRAAVPAAVGEPGSGPVAPPTLDSLPVVSKLPESIKAALRGEAAWAAALLGLSNGFPTPYYLAAMAAVLTSGAGVGQQLAALVVFNLVGFGAAIVPLISFWLAPEPTRSAVERIYAGMRTHHRLVVAVIAGLVGVFFVGLGISHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSS8</accession>
    <name>A0A132PSS8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_03840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844224.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21325"/>
    <dbReference type="EnsemblBacteria" id="KWX25406">
        <property type="protein sequence ID" value="KWX25406"/>
        <property type="gene ID" value="AFM11_03840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2644"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="348"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="435" mass="43886" checksum="6514182FB2BAA7C3" modified="2016-06-08" version="1">MTNHPRYTQQPDQRPGAAPGYSGGRPDPYQQQHYDWRYAQQAHQTQQQAYRAPYDPYRIPPSPQPPVVVAKKRSKAGLAAGALAVAVVSAGVGGGVATLVHQDSPRLGSSSSAAPTVPAAALPAGSVEQVAAKVVPSVVKLETDLGRASEEGSGIILTADGLILTNNHVVEAAKPGPGAQTAAQTKVTFSDGSTKPFTVVGTDPSSDIAVVRAQDVSGLTPITLGSSANLRVGQDVVAIGSPLGLEGTVTTGIISALNRPVAAGGDTRNQNTVLDAIQTDAAINPGNSGGALVNMNGELVGINSAIATMGGDSPQAQSGSIGLGFAIPVDQAKRIADELIQNGTASHASLGVQVANDRATDGAKIVEVTNGGAAAAAGLPSGVVVTKVDDRVISSADALVAAVRSKAPGEKVTLTYLDPAGKPQTLEVTLGRAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSU7</accession>
    <name>A0A132PSU7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_07135</name>
        <name evidence="11" type="ORF">AWC31_17580</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845907.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17580"/>
    <dbReference type="EnsemblBacteria" id="KWX25267">
        <property type="protein sequence ID" value="KWX25267"/>
        <property type="gene ID" value="AFM11_07135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17541">
        <property type="protein sequence ID" value="ORX17541"/>
        <property type="gene ID" value="AWC31_17580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4625"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX17541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="171" mass="18707" checksum="533B20BA7EBE74B3" modified="2016-06-08" version="1">MGSPIVVMGVSGSGKSTVGAALAQRLRVPFGDADDFHPPANVAKMTAGHALDDQDRYPWLEAIGEWLADHEDGGVMSCSALKRKYRDQLRRHCPDVQFLHLTGSPEVIGRRQASRPGHFMPPSLLASQFQTLEPLDPDEAGIAIDVDQNIDAIIDSYVTRTATRSTEQENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTU0</accession>
    <name>A0A132PTU0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XylR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844886.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21245"/>
    <dbReference type="EnsemblBacteria" id="KWX25684">
        <property type="protein sequence ID" value="KWX25684"/>
        <property type="gene ID" value="AFM11_03920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2661"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="376" mass="39219" checksum="F58DB3992B3C62B4" modified="2016-06-08" version="1">MIGLVRSQPGITRAVAAQRLRMSSGGATDLLARLRRVHLLDETPAPAQGRGRPTTVLGPHPDGPLVLVADLRPGDWRLAQAGFDGVPHIVAEGRSGEQARLLDDIASEIAKAHRKHTGRVRAIAVAVAGTVSDSRLVQFTPRGWSGIDLSAIMSRLPARTRPPLLLGNDATLAGLAEARAGSARDAGTALHLIITVGIGGTLIVNGEPVTGSHGAAGEYGHIPFGDPGLRCPCGARGCWDQTVDGRALARHLKLPQPRDPIAFAYEQLKANPAQPKLRAAFDAVATALGRGVAGLVNIHDPDIVTLGGLAPPLRAAAPEAFETAYRDGLMTFRKASAPPVRDGLLGEDAPMYGAAALAIDHVTTEAALADWAELHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU27</accession>
    <name>A0A132PU27_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmD</name>
        <name evidence="8" type="ORF">AFM11_00470</name>
        <name evidence="9" type="ORF">AWC31_33585</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842254.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33585"/>
    <dbReference type="EnsemblBacteria" id="KWX25805">
        <property type="protein sequence ID" value="KWX25805"/>
        <property type="gene ID" value="AFM11_00470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11619">
        <property type="protein sequence ID" value="ORX11619"/>
        <property type="gene ID" value="AWC31_33585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.95"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="7">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX11619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="59" mass="6837" checksum="40B0C2D9525EAA10" modified="2016-06-08" version="1">MAELKITQVRSTIGARWKQRETLRTLGLKKIRQSVVREDNAQTRGLIKTVHHLVDVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU66</accession>
    <name>A0A132PU66_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842417.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25860">
        <property type="protein sequence ID" value="KWX25860"/>
        <property type="gene ID" value="AFM11_00775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.159"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="75" mass="8323" checksum="9FD1157E217840DE" modified="2016-06-08" version="1">MADVLIRGLSDAAVARIDAAAAEQGLSRQEYLRRRFEAERAESLPHGRITVDDMRRAAAAAADLDDPDVMRDAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUB0</accession>
    <name>A0A132PUB0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_01255</name>
        <name evidence="7" type="ORF">AWC31_34290</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842667.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34290"/>
    <dbReference type="EnsemblBacteria" id="KWX25939">
        <property type="protein sequence ID" value="KWX25939"/>
        <property type="gene ID" value="AFM11_01255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11738">
        <property type="protein sequence ID" value="ORX11738"/>
        <property type="gene ID" value="AWC31_34290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.257"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="5">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="5">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX11738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="219" mass="24014" checksum="746D1E765DA91B94" modified="2016-06-08" version="1">MRDVFHDELSALGVRLSEMCGLAKSAMERATRSLLDADLTLAEEVIADHEHIAALNREVEHTAFKLLALQQPVAGELRMVVGSMHIAADIDRMGALAVHVANISRLRHPQCALPEDVRASFAEMGARAVQLAGTAQEVLLSRDPDTAARLRAEDDAVDAEHRHLFTLLIDHKWQTGVCSAVDVALLGRYYERFADHAVEIGKRVIFEATGGMPVHKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUC1</accession>
    <name>A0A132PUC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842673.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34305"/>
    <dbReference type="EnsemblBacteria" id="KWX25941">
        <property type="protein sequence ID" value="KWX25941"/>
        <property type="gene ID" value="AFM11_01270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.260"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017501">
        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03062">
        <property type="entry name" value="pip_yhgE_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="652" mass="68740" checksum="468CC36EDB1B5550" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUP8</accession>
    <name>A0A132PUP8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acyl-L-amino acid amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02215</name>
        <name evidence="2" type="ORF">AWC31_34995</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843138.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34995"/>
    <dbReference type="EnsemblBacteria" id="KWX26079">
        <property type="protein sequence ID" value="KWX26079"/>
        <property type="gene ID" value="AFM11_02215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11856">
        <property type="protein sequence ID" value="ORX11856"/>
        <property type="gene ID" value="AWC31_34995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.453"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="388" mass="40933" checksum="BA1349E49800CF6A" modified="2016-06-08" version="1">MSVLSHAAARWLSANYDEMVSWRRHIHAHPELGRQEFATTEFVARHLADAGLNPKVLPGGTGLTCDFGPEDGPRIALRADMDALPMADRTGASYASTVPNVAHACGHDAHTAVLLGTALALASASELPVGVRLVFQAAEELMPGGAIDAVNAGVLNGVSRIYALHCDPRLRVGRVATKPGPITSAADSIEITLHSPGGHTSRPHLTGDLVYGLGTLITGLPGVLSRRIDPRHDTVMVWGAVNAGVAANAIPQIGTLAGTIRTASRDTWLTLESIVEETVTSLLAPLNIEHSLNYRRGVPPVVNEEVSTRILTHAIEAVGPDVLADTHQSGGGEDFSWYLEEVPGAMARLGVWSGQGPQLDLHQPTFDIDERALGIGVRTMVNIIAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUU5</accession>
    <name>A0A132PUU5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843298.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35285"/>
    <dbReference type="EnsemblBacteria" id="KWX26128">
        <property type="protein sequence ID" value="KWX26128"/>
        <property type="gene ID" value="AFM11_02505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.513"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="452" mass="50066" checksum="947D383726A8087C" modified="2016-06-08" version="1">MAIDGPRLDGASALMTLSDLGFASISAGVIARRRPVLRLLERMQADTRAVKRLQRLRRQFGRGPVELVIPGRRIVVVLDPDDVGTVLSRSPQPFDPANREKRKALQWFQPHGVLISQGAIRSRRRAVNDAALDSGSDLHRLADAFATKIADEARDLVSEATSLGHLDSSLFMSAWWRLVRRLALGERARDDEAITDDLLRLRKAGNWSFLALPHYRARAQFTERLYGYAEDPEQGTLAGALAETPAAGAVDPVGQMPQWLFAFDAAGMALLRAIAVLATHPTHLDRAIDDCAEPERPLPRPYLRSCVLESVRLWPTTPTILRDTTEDTHWRDGADQFTIRKGAGVMIVTPAFHRDESLLPFAHDFTPDIWLDGRARRYPQLVPFSAGPAECPGRNLVLFTTSTLAANLLSRLRFELRSTPRPAPGEPLPMTLNQLDLEFSVRAAEPALAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV28</accession>
    <name>A0A132PV28_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_01845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842950.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34625"/>
    <dbReference type="EnsemblBacteria" id="KWX26017">
        <property type="protein sequence ID" value="KWX26017"/>
        <property type="gene ID" value="AFM11_01845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.379"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="43"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="243" mass="26774" checksum="442126720A554E67" modified="2016-06-08" version="1">MTSSRQQRSLSFGSEAAAYERGRPSYPPEAIDWLLPADAHDVLDLGAGTGKLTTRLVERGLDVVAVDPIAEMLELLSNSLPDTPALLGTAEEIPLPDNSVDAVLVAQAWHWFDPERAVKEVSRVLRPGGRLGLVWNTRDERLGWVKDLGRIIGHEDDPFNHQVTLPEPFADTERHQVEWTSYLTPQALIDLVASRSYCITSPEQVRTRTLGQVRELLATHPALANTTGLALPYVTVCIRATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV40</accession>
    <name>A0A132PV40_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843478.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26183">
        <property type="protein sequence ID" value="KWX26183"/>
        <property type="gene ID" value="AFM11_02845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.586"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="178" mass="19119" checksum="714E1FAB883D0076" modified="2016-06-08" version="1">MTQAEKGETPGVTEEVAEGAPRRSALWGWVVLALIVLALPVQAAWYTFTSSEPYPALTQPPFKTVPGADGTLSGRTETLAAVLADGSSVPLDADELFSDSWNQGSFVIDAIASQPEIDSRSRAMLRDEIGRHVPAGADVAYLRVVTQEREYRLSENRAYPISDAKTTDIPLGASNGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV60</accession>
    <name>A0A132PV60_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00050</name>
        <name evidence="2" type="ORF">AWC31_33155</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843540.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33155"/>
    <dbReference type="EnsemblBacteria" id="KWX26203">
        <property type="protein sequence ID" value="KWX26203"/>
        <property type="gene ID" value="AFM11_00050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12085">
        <property type="protein sequence ID" value="ORX12085"/>
        <property type="gene ID" value="AWC31_33155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.10"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021417">
        <property type="entry name" value="DUF3060"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11259">
        <property type="entry name" value="DUF3060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX12085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="109" mass="11418" checksum="B4194F993F67D6F6" modified="2016-06-08" version="1">MPAVLAVGTPTAAAKNGDTHVTGQGIEQTIDCNNSTLFVNGTGNQVNALGTCWAVTVQGSSNVVIADNVVNDITVYGWDQTVFFKNGAPVLVDRGRELGMTNRLDRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAQ7</accession>
    <name>A0A132PAQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_36000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000065">
        <property type="protein sequence ID" value="KWX19413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067860054.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31270"/>
    <dbReference type="EnsemblBacteria" id="KWX19413">
        <property type="protein sequence ID" value="KWX19413"/>
        <property type="gene ID" value="AFM11_36000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6578"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="157" mass="16373" checksum="F17CE16EFEAA76D8" modified="2016-06-08" version="1" fragment="single">CTISDLILIAAGIAGVGALITAHPDAVTVAKFGGAAFLIGYGVLAARRAWRPSTLNPSERSPARLAEVLVTCLALTWLNPHVYLDTVVLLGTLANEHHSQRWLFGAGAVAASALWFTGLGLGARRLAGLFATPMTWRILDAVIAVMMIGLGIGMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAT9</accession>
    <name>A0A132PAT9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_35845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000052">
        <property type="protein sequence ID" value="KWX19439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067860019.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22465"/>
    <dbReference type="EnsemblBacteria" id="KWX19439">
        <property type="protein sequence ID" value="KWX19439"/>
        <property type="gene ID" value="AFM11_35845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6248"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="91"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX19439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="200" mass="20778" checksum="E0B42A9519C6875B" modified="2016-06-08" version="1" fragment="single">MLQMVLNYLGIAVFASSGAMVAIRKGFDLFGIAALGIMTGVGGGVVRDLFLNISPPTSIQHWPNVTVALVATAVATLTARLFIRMRRSVLTLDAIGMGFFATSGAAIAVDHGASWFAAALIGMTTAIGGGIIRDVLAREVPMLLGPDELYAVPAMLGAAAYAVIDYLGPQWVGLVVGTVLATVLRLAGLVFHWRLPTGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB58</accession>
    <name>A0A132PB58_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin-antitoxin system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036405108.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19559">
        <property type="protein sequence ID" value="KWX19559"/>
        <property type="gene ID" value="AFM11_35250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5781"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="65" mass="7098" checksum="59A7E0BC8E2F2B0D" modified="2016-06-08" version="1">MAQPHKGPREQIKVRADASVYARLREMAAERGTSVSQLSADLLAIAVGRPEAVRELDKEVLPLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB94</accession>
    <name>A0A132PB94_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34905</name>
        <name evidence="2" type="ORF">AWC31_02120</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859541.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02120"/>
    <dbReference type="EnsemblBacteria" id="KWX19588">
        <property type="protein sequence ID" value="KWX19588"/>
        <property type="gene ID" value="AFM11_34905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13341">
        <property type="protein sequence ID" value="ORX13341"/>
        <property type="gene ID" value="AWC31_02120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5710"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX13341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="371" mass="42056" checksum="C767A083D7AFFB45" modified="2016-06-08" version="1">MLTPHDELLCHQLPTTFDHVAQSDLRWTERIVMYGFDRSGEVNVMTGLARYPNRNVTDAYAMITKRGGEARVVRMSTELNPESGALGTYSVGPYTYSVEEPLRTVRAVLEPNEQGVSLDLRLRGQFPTYEQTPAFHRSRGRVSEDARRFYQNGDLEGWIEIDGERIEIDTSRWWFGRDHSWGIRNGPGGGSLPEGVHLQPQEIPDGTLYYMGIFEFEDELVHFAQRETSTGDRWQFEGEILYPLATERPAATIIDVEHDLKFRDELRVISGGTFTVHRGDRSTSTIEVTPITDFWPGLAGYMEVDGYASGHWRGKEFIDGFTADTTDLSVIKPVSFLSETLCEVRMDGKTGHGLVEMVFVGAYPRYGYTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBD7</accession>
    <name>A0A132PBD7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_34980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02040"/>
    <dbReference type="EnsemblBacteria" id="KWX19614">
        <property type="protein sequence ID" value="KWX19614"/>
        <property type="gene ID" value="AFM11_34980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5725"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452963" description="SBP_bac_5 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="112"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="555" mass="59630" checksum="603FB016303461DA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBE5</accession>
    <name>A0A132PBE5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_34505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859304.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17290"/>
    <dbReference type="EnsemblBacteria" id="KWX19653">
        <property type="protein sequence ID" value="KWX19653"/>
        <property type="gene ID" value="AFM11_34505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5246"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta_toxin" evidence="3">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="192" mass="20669" checksum="94FD486DCABD9587" modified="2016-06-08" version="1">MKRLDLVVGSNGAGKSTFIELTLAPLLPGSPVVNADEIAKRRWPVSAATHAYEAAAVAAETRAKLIERGESFIAETVFSHASKLDLIGDAHAAGYIVILHAVLIPEDLAVLRVRHRVEAGGHDVPEHKVRERYQRLWDLVAIAAARADSATFYDNSTLKGPRIVAQVAGGFIVGSPAWPTWTPAPLVAQWPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBH2</accession>
    <name>A0A132PBH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_34675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859395.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22245"/>
    <dbReference type="EnsemblBacteria" id="KWX19679">
        <property type="protein sequence ID" value="KWX19679"/>
        <property type="gene ID" value="AFM11_34675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5282"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="4">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="561" mass="61381" checksum="F55A26AB7DD59A39" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBI1</accession>
    <name>A0A132PBI1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_35015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859613.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19607">
        <property type="protein sequence ID" value="KWX19607"/>
        <property type="gene ID" value="AFM11_35015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5732"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="468" mass="50929" checksum="A2679739082C3923" modified="2016-06-08" version="1">MLDHARTAEATLPRQTRTADRDQIRAIRQREEERFAHDRPKSFELVQRARRSLLGGVPMNWMTKWPGGFPPFIASARGARLVDVDGNAYIDFCYGDTGAMAGHAPAGSVGAIADRAADGITFMLPTEDAIWVGEEMTRRFGVPFWQFALTATDANRFVLRLARMITGRRKVLVFNHCYHGSVDESLATLVAGTIHPRRGNIGPAVPPSETTQVVEFNDTAALERALAEGDVACVLAEPALTNIGIVLPEPGFHDALRELTRRYGALLVIDETHTICAGPGGYTKAHGLQPDFVTVGKSIGSGVPSAAYGFTAEIAERIEHQVSVEDADVSGVGGTLAGNALSLAAVRATLANVLTEQAFVGMTDLAVRLEQDVNDLIESNDLPWHVTRLGCRVEYLFSAERARNGTQAANAGDFELDQLIHLYMLNRGVLLTPFHNMTLMSPANVAEDVERHKEILTEAIAELYPAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCC0</accession>
    <name>A0A132PCC0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-ketosteroid-delta-1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_33085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858608.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17140"/>
    <dbReference type="EnsemblBacteria" id="KWX19968">
        <property type="protein sequence ID" value="KWX19968"/>
        <property type="gene ID" value="AFM11_33085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4949"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="568" mass="60847" checksum="8EE868774A2AD6BF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCP6</accession>
    <name>A0A132PCP6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_32620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858173.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19755"/>
    <dbReference type="EnsemblBacteria" id="KWX20100">
        <property type="protein sequence ID" value="KWX20100"/>
        <property type="gene ID" value="AFM11_32620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4852"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3417" evidence="11">
        <location>
            <begin position="13"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX20100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="867" mass="95925" checksum="607BEF91D262D605" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDB5</accession>
    <name>A0A132PDB5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">AFM11_31450</name>
        <name evidence="11" type="ORF">AWC31_25605</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX15076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857676.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25605"/>
    <dbReference type="EnsemblBacteria" id="KWX20306">
        <property type="protein sequence ID" value="KWX20306"/>
        <property type="gene ID" value="AFM11_31450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15076">
        <property type="protein sequence ID" value="ORX15076"/>
        <property type="gene ID" value="AWC31_25605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4196"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX20306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX15076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="132" mass="14045" checksum="F962390018B8454A" modified="2016-06-08" version="1">MFGHDPRELAAVFVGGALGTLARAGLETLLAPDPGRWPWPTFCVNIVGAFLLGYFTTRLLERLPVSSYRRPLLGTGFCGGLTTFSTMQVETITMIEHGHWALAAGYTAASIVAGLLAVVIGTAVVRRVSVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDJ3</accession>
    <name>A0A132PDJ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycogen synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_31160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857316.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26870"/>
    <dbReference type="EnsemblBacteria" id="KWX20405">
        <property type="protein sequence ID" value="KWX20405"/>
        <property type="gene ID" value="AFM11_31160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4136"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="15"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="211"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="413" mass="44935" checksum="71AB359A220439D8" modified="2016-06-08" version="1">MKILMVSWEYPPVVVGGLGRHVHHLATALAADGHEVVVLSRRPSGTDPSTHPSTDVVSEGVRVVAAAQDPHEFEFGTDMMAWTLAMGHAMVRTGLAVRDRSGNPWLPDVVHAHDWLVAHPAIALAEFFDVPLVSTIHATEAGRHSGWVSGPISRQVHAVESWLVRESDSLITCSASMNDEIIELFGPDLAEIRVIRNGIDAELWPFARRRPRQGPAQLLYVGRLEYEKGVHDAIAALPRIRRAHPGTTLTIAGDGTQQQWLIEQARKHKVLKATRFVGRLGHDDLVRALQEADAAVLPSHYEPFGIVALEAAATGTPLVTSNVGGLGEAVIDGQTGMSFAPRDVAGLAAAVRAVLDDPAAAQRRAVAARERLTADFDWHTVAAETSQVYLAAKRREREPHPRRPIVEHALPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDN3</accession>
    <name>A0A132PDN3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856772.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20446">
        <property type="protein sequence ID" value="KWX20446"/>
        <property type="gene ID" value="AFM11_30140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3922"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="234"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="354" mass="35166" checksum="A0A6C7FE4A672B8F" modified="2016-06-08" version="1">MSLDALVAEVGQVLGDARRLYGPAPTAGGWSSTTALSAGKDGLAQTGGVLSGWGGASATTHLAANGGRVLALDNVIGADRGTAPGFTGAAQTSQSGGGGMDEVNADTRRGVAAIAPSTDTPAGKAQLVDHLQSQLDRAKALLKVSESRNIMLANLIRSASGGYGGAMPMGAGMGGPMGGGMPMGGMGGGGMPGLGGAGLIPNLSAFTRTAASTRNRTGSRPGFEPLAAAGSGGGPLAQMAVKAALSKRGTPYVWGAKGPNVFDCSGLTQWSWGQAGVTLGPDTYTQIKQGVAVAPGDVQEGDIIFPKDSWDDRGPGHVMLAISPTQVVHAPQTGDVVKIAPMPAEFVARRPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDS1</accession>
    <name>A0A132PDS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856867.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20473">
        <property type="protein sequence ID" value="KWX20473"/>
        <property type="gene ID" value="AFM11_30330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3964"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="90"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="222" mass="24358" checksum="A8352B62A28E2C75" modified="2016-06-08" version="1">MTDSPVTHQLRGDLSIDQQLALKTAATRLESEFADTFGTETIERFLCSSYDQFASRATIANFLPLLAERFARQRLHALARVEGKVSDGKPTVLFLCTHNAGRSQMALGFFTHYAGDNAIAWSGGSEPGNEINPAAIEAMREVGIDITGEYPKPWTDEIVQAADVVITMGCGDACPIFPGKRYENWELPDPAGQGLDAVRPIRDQIDQRIHQLLAELNVPVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDW2</accession>
    <name>A0A132PDW2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856909.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20484">
        <property type="protein sequence ID" value="KWX20484"/>
        <property type="gene ID" value="AFM11_30405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3981"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="123" mass="13694" checksum="F039BA12578D7566" modified="2016-06-08" version="1">MRSFGELEAAIMGVAWAAADAVTVRDVVEALRDTRNPAYTTVQTVMDILHTKGWLDRDKRGRAYRYHPTATQQEYAARLIGDVLAETPHRAGVLAKFVTELDPDELDELRVALRKAKAKRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDW5</accession>
    <name>A0A132PDW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein-S-isoprenylcysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_30365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857033.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20529">
        <property type="protein sequence ID" value="KWX20529"/>
        <property type="gene ID" value="AFM11_30365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3971"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="220" mass="23383" checksum="5FABAEC849D8CC43" modified="2016-06-08" version="1">MAYAALGLFGVLMLVIGAWRRRIQLARTGDSGNRRRWRPDGSLEWWALAIADVGYLLVGVGAPIAALAGLPALGVLDRVWVHGLGIVVAVAGITLTLLAQLGLGASWRIGVDETERTELVTTGPFALVRNPIFTALLGTLTGLALMVPNPAAIAGLVIAAAGIELQVRKVEEPYLRRVHGAAYTNYTAAVGRFLPRFLPRIGRTRPIPAREANDAAPQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEH2</accession>
    <name>A0A132PEH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxy-2-methylbutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011331213.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20721">
        <property type="protein sequence ID" value="KWX20721"/>
        <property type="gene ID" value="AFM11_29375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3766"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="25706" checksum="0C7E98B5C051A4CA" modified="2016-06-08" version="1">MHITGTNALVTGGASGLGLATVTALAKSGARVIAVDLPTANTDALAALGDTVEFAPADVTDEAAVTEAVERANAESSLRITVNCAGIGNAVKTVGKNGPFPLAEFEKIVKVNLTGTFNVIRLAAHAMSQNEPVDGERGVIVNTASVAAFDGQIGQAAYSASKGGIVGATLPIARDLASLLIRVNTIAPGLFKTPLLGTLPEAAQISLGQQVPHPNRLGDPAEYAQLVEAIVTNPMLNGETIRLDGAIRMAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEM6</accession>
    <name>A0A132PEM6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_29055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13502"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040114.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20677">
        <property type="protein sequence ID" value="KWX20677"/>
        <property type="gene ID" value="AFM11_29055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3693"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="94"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="564"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX20677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="660" mass="70799" checksum="39D7E14EA81E50C6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEM8</accession>
    <name>A0A132PEM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856760.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20442">
        <property type="protein sequence ID" value="KWX20442"/>
        <property type="gene ID" value="AFM11_30115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3916"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="164" mass="18974" checksum="93B18C03A49C1925" modified="2016-06-08" version="1">MSATVSTPNPGRWLEVLLRRQPHQIIDNHGAPYLQRWYLIPRNRLCNIYLHRFVASDDPTCHDHPWAFASVILRGGYTEIQPDRITVRRAGSFAVRRAQHRHSVRLPRTADGREIPCLTVIITGPRVRNWGFWCPDRNQADRFVPWRQFGPGGCGESQTEVAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEX9</accession>
    <name>A0A132PEX9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855977.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10340"/>
    <dbReference type="EnsemblBacteria" id="KWX20898">
        <property type="protein sequence ID" value="KWX20898"/>
        <property type="gene ID" value="AFM11_27810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3436"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="350" mass="38134" checksum="A979C22498350C2E" modified="2016-06-08" version="1">MRVVVVGATGNVGSSVVEVLAADEQVDSIVGIARRRPTWQPPKTTWVQADVYRDDLDGHFAGADAVIHLAWIFQPTHDELATWRNNVLGSIRVFDAVARAGVPVLVYASSVGAYSPGPDDGVDESWPTHALPTAAYGREKSYLERVLDSYERDHADIRVVRMRPGFIFKREAATEQRRLFGGPLVPTSLIRPALLPVVPDLPGFRLQALHSRDAAHAYRLALIRPVHGAFNLAAEPVLDARTLGEILGARPIKLPIPPIRAAVAAAWNLHLLPASPTLVDLALSLPVMDTARARSELGWTPTISSLDTIREFLEGLRDGSGMDTPPLDPKAGGRFRYRELATGVGQRARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEZ6</accession>
    <name>A0A132PEZ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="12" type="ORF">AFM11_27930</name>
        <name evidence="13" type="ORF">AWC31_10450</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855766.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10450"/>
    <dbReference type="EnsemblBacteria" id="KWX20919">
        <property type="protein sequence ID" value="KWX20919"/>
        <property type="gene ID" value="AFM11_27930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08916">
        <property type="protein sequence ID" value="ORX08916"/>
        <property type="gene ID" value="AWC31_10450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3460"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX20919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX08916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="209" mass="22973" checksum="6B5E4CA7D8C7CD27" modified="2016-06-08" version="1">MGNLHLIDHPLIQHKLTLMRQKDVSTNGFRQLLAEISMLMTYEVLRDIPLHEIEIDTPLESTTGAVIDGKKLVFVSILRAGSGILEGMLSVVPSARVGHIGLYRDPKTLVAVEYYFKLPSDLAERDVVVVDPMLATGNSAVAAIDRIKEYRPRSIKFVCLLTCPEGVAAMQAAHPEVPIYTAALDRRLDEHGYIVPGLGDAGDRIFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFB7</accession>
    <name>A0A132PFB7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855253.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06845"/>
    <dbReference type="EnsemblBacteria" id="KWX21036">
        <property type="protein sequence ID" value="KWX21036"/>
        <property type="gene ID" value="AFM11_26995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3273"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453231" evidence="1">
        <location>
            <begin position="40"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="189" mass="19052" checksum="793A3EBF2DCE4C50" modified="2016-06-08" version="1">MGWQFGAGLKLAASALGGVAVTAMVVVGCTSVTDGTAQVDSEAAPDYRASVSASVEASESSSAVRESERQASLTTKAVHTVCEDLSTSSVDAVDAVNIYIEAVNNNAPDVQAKAGPAVDALNRSADLVSSGITEALSPDLSGALTEWVEAVRAVAAAISGNAAPDVFNAASERSNTARTNALDRCDAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFS1</accession>
    <name>A0A132PFS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26350</name>
        <name evidence="2" type="ORF">AWC31_23240</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854876.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23240"/>
    <dbReference type="EnsemblBacteria" id="KWX21180">
        <property type="protein sequence ID" value="KWX21180"/>
        <property type="gene ID" value="AFM11_26350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15494">
        <property type="protein sequence ID" value="ORX15494"/>
        <property type="gene ID" value="AWC31_23240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3137"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX15494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="355" mass="38442" checksum="92987A48E1398D0F" modified="2016-06-08" version="1">MLRLPELPGVPGVLTPDDCLQTARSIAATQESSGALPWFDGGHTDPWDHVENAMALTVAGLIEPARAAFDWCRTVQRADGSWPIQLRNGVVEDANSDSNFCAYVATGVWHHVLVTGDRGFAETMWPVVTRAIDFVLGLQAPGGEIYWASTPSGPVEEALLTGCASVYHSIRCGLALADYLGDPQPEWEVAVGRLGHAIAEHPEAFAAKDTHAMEWYYPVLGGALLDDAARSRIDGRWDDFVVPGLGIRCVDHRPWVTGAETCELVMALDAIGDTRRAHEQFAAMHHLREADGSYWTGLVFADGKRWPEERTTWTGAAMILAADALSSTTAASGIFRGEGLPRGLEGEYDCECVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFX3</accession>
    <name>A0A132PFX3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diacylglycerol acyltransferase/mycolyltransferase Ag85A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_26740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855076.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22595"/>
    <dbReference type="EnsemblBacteria" id="KWX21248">
        <property type="protein sequence ID" value="KWX21248"/>
        <property type="gene ID" value="AFM11_26740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453242" evidence="3">
        <location>
            <begin position="35"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="347" mass="36957" checksum="E3C01D99AC3D7ADD" modified="2016-06-08" version="1">MTPGVNAARIWGRRILAIAAATVALPTLAVVAGGEPSASAFSREGLPVEYLDVYSPSMGRNIRVQFQGPSEAPPPPADGAALAAPAPPTPSRAVYLLDGLRAQDDYSGWDINTPAFEWFYGSGISTVMPVGGQSSFYSDWYSPSSFNNQTYTYKWETFLTQELPAWLAANKQVSQTGNGVVGLSMSGSAALILSAYHPGQFRYAASLSGFLNPSALLMQQAIRVAMLDAGGYNVDNMWGAPWDGAWKRNDPVKQAAKIVANGTRLWIYCAPGGSTPLDEGADPNLAMSANSLETLAIKSNKDFQDAYVKAGGRNASFHFPPAGNHAWPYWGAQLTALKPDLIATLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG71</accession>
    <name>A0A132PG71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_25720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854494.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36175"/>
    <dbReference type="EnsemblBacteria" id="KWX21325">
        <property type="protein sequence ID" value="KWX21325"/>
        <property type="gene ID" value="AFM11_25720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3008"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="IclR-ED" evidence="3">
        <location>
            <begin position="72"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="249" mass="26364" checksum="F140E422BBD59931" modified="2016-06-08" version="1">MAGNTSVPGATVASRLLAIIAAFDERHRALTLTELAQRANLALPTASRLAGELVAGAALDRRADGRYVIGRLLWEAGLRAPVEGRLKQAAEPFLHDVYAATLATVHLAVRDGPQVLYLERMSGRASVPIVSTVGSRLPLHCTGVGKVLLAHAPKDVERQALANLTRVTPYTITTPNVLVAQLEQIRRDGVATTVEEMSLGACSMAVPVIRASDDTVAAAIGVVVPTLKRDRQRLLGALQVAARGIGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGF1</accession>
    <name>A0A132PGF1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854540.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36060"/>
    <dbReference type="EnsemblBacteria" id="KWX21344">
        <property type="protein sequence ID" value="KWX21344"/>
        <property type="gene ID" value="AFM11_25835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3031"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="216" mass="22127" checksum="CC6C630CF1A1B823" modified="2016-06-08" version="1">MSWTREQMAARAAAELHDGDYVNLGIGLPTLIPDYLPEGSDVTLHAENGILGVGPFPYDDEVDPDLINAGKQTVSVVAGASFFDSATSFAMIRGGHVDVAVLGGMQVAANGDLANWMVPGSMVKGMGGAMDLVSGAGRVIVLMDHVAKSGGAKLVSTCNLPLTGKAVVSRVITDLGVFDVTGDGFRVVELAPGVDYDDVVAKTGATVIDGRVPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGP1</accession>
    <name>A0A132PGP1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="9" type="ORF">AFM11_25150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854179.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27470"/>
    <dbReference type="EnsemblBacteria" id="KWX21500">
        <property type="protein sequence ID" value="KWX21500"/>
        <property type="gene ID" value="AFM11_25150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2391"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="264"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="346"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="408"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="456" mass="47268" checksum="2F84F50D61C73AFB" modified="2016-06-08" version="1">MTDGALIGLWIAIAVVAVLLIVALVVGLVRYRRRRVSLSEPDKPASIDRSGGYTASSGITFSQSTTPTVERIDTSGLPAVGDDATIPRDAPKRPIADVQLPDAPVAPPAEPQAPPAPAEPTAPAEPQAPAEPAPIEAPVDEAAPSVIEDIAPPEGRLDRLRGRLSKSQNALGRSMLGLLGGGDLDEDSWEAVEDTLLIADLGPVVTQSVVASLRAKMASKGVRNEADARAVLREVLISELRPELDRSIKALPHADKPSVLLVVGVNGTGKTTTVGKLARVLVADGRRVVLGAADTFRAAAADQLQTWAARVGADVVRGPEGADPASVAFDAVDEGISEGADVVVIDTAGRLHTKTGLMDELGKVKRVVEKRAAVDEVLLVLDATIGQNSLPQAKVFAEVVDITGVVLTKLDGTAKGGIVFRVQQELGVPVKLVGLGEGPDDLAPFEPGAFVDALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGR7</accession>
    <name>A0A132PGR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854272.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27665"/>
    <dbReference type="EnsemblBacteria" id="KWX21535">
        <property type="protein sequence ID" value="KWX21535"/>
        <property type="gene ID" value="AFM11_25345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2431"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="777" mass="82651" checksum="8DE26D278667A2A7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGU8</accession>
    <name>A0A132PGU8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="11">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="11">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gatB</name>
        <name evidence="13" type="ORF">AFM11_24785</name>
        <name evidence="14" type="ORF">AWC31_27040</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="11"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854003.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27040"/>
    <dbReference type="EnsemblBacteria" id="KWX21437">
        <property type="protein sequence ID" value="KWX21437"/>
        <property type="gene ID" value="AFM11_24785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14816">
        <property type="protein sequence ID" value="ORX14816"/>
        <property type="gene ID" value="AWC31_27040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2318"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="12">
        <location>
            <begin position="353"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX21437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX14816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="504" mass="54297" checksum="30C8931877DA7C92" modified="2016-06-08" version="1">MTVASTAELVDYDDVIARYEPVMGMEVHVELSTATKMFCGCANRFGAEPNTLVCPVCLGLPGSLPVLNQAAVESAIRIGLALNCQIAPWGRFARKNYFYPDQPKNYQISQYDEPIAINGYLDVPLDDGTTWRVEIERAHMEEDTGKLTHLGSDTGRIAGATTSLADYNRAGVPLIEIVTKPIEGTGARAPEIARAYVTALRDLLRALGVSDVRMDQGSMRCDSNLSLKPVGAAEFGTRTETKNVNSLRSVEVAVRYEMRRQAAVLDAGGKVTQETRHFHEDGYTSPGRSKETAQDYRYFPEPDLEPVAPSAELVEQLRETIPELPWLSRKRIQDEWGISDEVMRDLVNNGAIDLVAATVAHGASSEQARAWWGNFLVQKANEAGVELEALAITPAQVAAVVKLVDEGKLSNKLARQVVEGVLAGEGEPEQVMTDRGLALVRDDSVIQAAVDEALAANPDVAEKIRGGKVQAAGAIVGAVMKATKGSADAARVRELVLAACGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGV2</accession>
    <name>A0A132PGV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854347.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27425"/>
    <dbReference type="EnsemblBacteria" id="KWX21560">
        <property type="protein sequence ID" value="KWX21560"/>
        <property type="gene ID" value="AFM11_25105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2382"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="188" mass="21276" checksum="A7C5464A45408892" modified="2016-06-08" version="1">MPNTFVQSTDDVVKFLRDQHNLIKDLFEEVFSASTDEAREKAFIELRQLLAVHETAEEMVVHPRVRREVADGEEIVEARLHEEHAAKEQLSKLESMDIGSEEFITELTKFREAVIDHADHEEQEEFNKLQRKLDADDLERMAKAVQAAEAIAPTRPHAGVESATANFAIGPFASMLDRARDLIGAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGZ8</accession>
    <name>A0A132PGZ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853551.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21606">
        <property type="protein sequence ID" value="KWX21606"/>
        <property type="gene ID" value="AFM11_24025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2164"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="100" mass="10993" checksum="E595B2394FD7651B" modified="2016-06-08" version="1">MPVTGSLTSRPALDDLIDVVKALGDPVRVDMLERIAAVEQMACTDLVDELKVSASTVSYHVKLLRTAGLIDVRKEGRNFFYTYRRETAAKLAEALLGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH08</accession>
    <name>A0A132PH08_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853588.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21616">
        <property type="protein sequence ID" value="KWX21616"/>
        <property type="gene ID" value="AFM11_24100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2179"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="17162" checksum="99869FDFA8EE85E6" modified="2016-06-08" version="1">MHDVLAWLESSALGAFMRDTGPWTYPIVNLIHILGVATLFGAVLILDLRLLGLWRRVPLRAITSTASPVATAGFVVAALSGPCLLASNALDYDQNPVLLVKFGAIGLGMVNVVLLRRTSAWRAHTTGELSHAQARLPAAFAGVSLASWLTAVTAGRMLGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH95</accession>
    <name>A0A132PH95_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853818.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23525"/>
    <dbReference type="EnsemblBacteria" id="KWX21691">
        <property type="protein sequence ID" value="KWX21691"/>
        <property type="gene ID" value="AFM11_24595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2280"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="218" mass="23029" checksum="3A2146EB51DC9F86" modified="2016-06-08" version="1">MTPTLDYDGEIAVLDLGDDENRFSPEFLDAVDALLDTVLDKGAQGLVTTADSKFYSNGLDLDWLGAHSDQGPWYVGRVQGLLARFLTLPIPTAAALVGHAFGAGAMLAVAHDYRVMRADRGFFCFPEVDIRIPFTPGMAALIQAKLTPRAAVASMTTGRRFGGVDAHEYGLVDATAAEGAVTLTATEMLRPLGGKDPGTLGAIKQVMFGRAADALRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHD7</accession>
    <name>A0A132PHD7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853896.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21723">
        <property type="protein sequence ID" value="KWX21723"/>
        <property type="gene ID" value="AFM11_24215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2202"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="297" mass="33868" checksum="799973CAD4816CB5" modified="2016-06-08" version="1">MDRNRSKLADFLSTRRARLTPEDVGFGGEFARRRVPGLRREELAQLAGVSVDYYTRLEQGRSRSASADVLDALATALQLNDAEREHLHKLGRPQPETRRRRSRPQHVHPATLDLLDRLDGVLSPAFILGRRLDVLAHNRLAGALITEFRHLPAPQRNQARFVFLDPHARELYTDWRQVAMDTVAMLRHDAGRYPDDPKLSALVGELSIHSDEFRTWWARHDVQRRTTGTKSYHHPVVGDLTVQYQALNPSGDEDQVLIVYTAEPDSASDTALRLLANWREREHVSGTDTVSVRKESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHN0</accession>
    <name>A0A132PHN0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853232.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28260"/>
    <dbReference type="EnsemblBacteria" id="KWX21821">
        <property type="protein sequence ID" value="KWX21821"/>
        <property type="gene ID" value="AFM11_23535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2062"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="129" mass="14519" checksum="F04142247ECA1ADB" modified="2016-06-08" version="1">MSKRKEEARTFLISVAAELAGMHAQTLRTYDRLGLVSPQRSSGGGRRYSERDVDLLREVQRLSQDEGVNLAGIKRIIELTNQVDALRARVSELTQQVEQLTAANQHRDVSVSSKAVVLWQPAARRRHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI46</accession>
    <name>A0A132PI46_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852834.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08430"/>
    <dbReference type="EnsemblBacteria" id="KWX21983">
        <property type="protein sequence ID" value="KWX21983"/>
        <property type="gene ID" value="AFM11_22770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1906"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="126" mass="13773" checksum="C75F528BED3FFC91" modified="2016-06-08" version="1">MALTFADVAGSEYILLTTFTKDGREKPTPIWAAPDGDGLIVITQEKSWKVKRIRNTPRVTIAKCDMRGNPKSEPVEAVAAVNAVRTADAYRAIGSRYGLLGKTFNFFSKLRGGMKNNVALEIRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIB0</accession>
    <name>A0A132PIB0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_22920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852981.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22051">
        <property type="protein sequence ID" value="KWX22051"/>
        <property type="gene ID" value="AFM11_22920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1937"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="183" mass="19852" checksum="894E75E8B351E905" modified="2016-06-08" version="1">MRADAVRNRDRLVTAAAELFTERGVDVPLDEIARHAGVSIGTLYNHFPNRGALLDAVLPDRLAAIDRMARHALDDPDAWRGFTGFLDGLFSMQATDRSINDAIARNPVGSVDVAGECGRAGGLLEEVVERAKQAGVLRTDFGTEDLATLMWAMSKVIAMADGRDAVWRRHLGFVLDGLKPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIB9</accession>
    <name>A0A132PIB9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_21335</name>
        <name evidence="6" type="ORF">AWC31_04150</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852294.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04150"/>
    <dbReference type="EnsemblBacteria" id="KWX22061">
        <property type="protein sequence ID" value="KWX22061"/>
        <property type="gene ID" value="AFM11_21335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10501">
        <property type="protein sequence ID" value="ORX10501"/>
        <property type="gene ID" value="AWC31_04150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1614"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX10501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="239" mass="26043" checksum="30D94E5E824EC630" modified="2016-06-08" version="1">MTALDDAPTTAAADVKKPVIEISDVWKLHKLGDEVVKALVATELQVMPGEFVCLMGPSGSGKSTLLNIMGGLDRPTKGTVKIGGRDTAQLTESQFAALRHDTIGFIFQSYNLIPFLSAVENVELPLMFEPYDRKSLRKRAIELLEMVGLSHRVHHQPTKMSGGEQQRTAIARSLISSPTLVLADEPTANLDHRTGETVVRMLRDLCSTMGVTVVASTHDPTVADEASRVVRMRDGQIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIC3</accession>
    <name>A0A132PIC3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852345.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04290"/>
    <dbReference type="EnsemblBacteria" id="KWX22085">
        <property type="protein sequence ID" value="KWX22085"/>
        <property type="gene ID" value="AFM11_21475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1643"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="268" mass="29368" checksum="D06E339248354BD9" modified="2016-06-08" version="1">MSDSYYELIDDADPRGQRFRATDMVRGTWSAAIQHAAPVSALLVRALETCALRADTRLSRVAIDLLGGVPSEGDLWVRATVERPGKQIELLTAEMLAPGPDGTPRPVARASGWRMRTLDTAALQHAAAPPLPPLDEARSRDMAKNWEPNYVHSLDWRWLTVPQAPGPGESWLKPTVDLVKGEAMTPLQRLFAVADDANGIGSKIDIRKWTFLNTDLVVHIHRIPDGEWIGIRADTNYGPDGIGTTMGTLFDQKGAVGAIQQSVLVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PID5</accession>
    <name>A0A132PID5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_23175</name>
        <name evidence="8" type="ORF">AWC31_27940</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853052.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27940"/>
    <dbReference type="EnsemblBacteria" id="KWX21762">
        <property type="protein sequence ID" value="KWX21762"/>
        <property type="gene ID" value="AFM11_23175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14970">
        <property type="protein sequence ID" value="ORX14970"/>
        <property type="gene ID" value="AWC31_27940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1987"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX14970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="320" mass="35188" checksum="9059981FD3FE3019" modified="2016-06-08" version="1">MARFIVRRVLGMIAVLFAISLLVFVIFNVIPNSDPAARIAGKNANPALIARVSQDLGLDQPLPVQYLTMMKQIVTGQLTSYASNRNVAEQIWEGLPATMSLCIGAAVLWMALAIWFGYLSAVHAGRFTDRALTVLSLAGISMPVFWLAAILLYYLSYKLELFPASSYVPLAENPLQWAYHLILPWVTLAVLYVGFYSRVLRTNMLDVANEDYVRTARAKGISERQVRTRHILRNSLIPIVTLFGLDFGAVVGGGAILTETVFNINGVGLYAGEAIRTLDLPPLIGVTMYGAFFIVLFNTIVDLAYAYLDPRIRLGEAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIE3</accession>
    <name>A0A132PIE3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852784.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08580"/>
    <dbReference type="EnsemblBacteria" id="KWX21957">
        <property type="protein sequence ID" value="KWX21957"/>
        <property type="gene ID" value="AFM11_22625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1875"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="25286" checksum="584513C1D321F512" modified="2016-06-08" version="1">MIALVTGAGGGIGSATVHRLVRDGVHVIATDVGERAPGLPSEADYVRFDLLDGDPAELFGRLDGRGLDYLVNAAGVALFDRDGSTLDIDESVWDLTLGVNLHGLRKVTTAAVDHLRRGNGKSIVNVASTAGLRGMDSPLDAYQVSKAAVVSLTRALALHLAPEGIRANTVCPGAILTPMIDYLYVDNPARRADMESRTPLRRLGMPDEIANAIAFLLSADASFVTATDLVVDGGWTAQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIW2</accession>
    <name>A0A132PIW2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852109.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06290"/>
    <dbReference type="EnsemblBacteria" id="KWX22290">
        <property type="protein sequence ID" value="KWX22290"/>
        <property type="gene ID" value="AFM11_20875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1514"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="441" mass="47452" checksum="10FC15BBD1D35560" modified="2016-06-08" version="1">MRRSTQLAAGLALTMVLLLVAAMLLGRDTEPSGKTVVTVRLWDPQVAAAYRESFDAFSAEHPDIEVRVNTVAYSTYFDTLRTDVAGGSADDIFWISNAYFAGYADNGRLLDIGKLLGPNAARAWEPSVVNQFTRNGTLWGVPQLTDAGIAVYFNADLLDAAGVGLAELPTLRWSNGPDDTLRPLLARLTVDEAGRTAATPGFDANRTRQWGYNAANDLQGIYLNYIGSAGGIFAIGDRFAFNNPQSVEAFEYLVRLINEDHVAPPASDTNNNGDFSRNAFLQGRMALFQSGTYNLAAIANQARFRWGVVMLPAGPKGRVSVTNGIAAAANPATRHPDAVREVLAWMGSKRGNEFLGVRGAAIPAVLAAQPVYHDYWKARGVDVSPFFRVLRGPRIPAPGGAGFPAGYEAIKPYFDEMFLGRGDVATTLADAQWAANAAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIZ5</accession>
    <name>A0A132PIZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22765</name>
        <name evidence="3" type="ORF">AWC31_08435</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852833.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08435"/>
    <dbReference type="EnsemblBacteria" id="KWX21982">
        <property type="protein sequence ID" value="KWX21982"/>
        <property type="gene ID" value="AFM11_22765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10187">
        <property type="protein sequence ID" value="ORX10187"/>
        <property type="gene ID" value="AWC31_08435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1905"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="154" mass="16263" checksum="CFF6128C250BF3CA" modified="2016-06-08" version="1">MLMRYFLLYVIVEMAVIVALAATIGVGWTLLALVGAFVVGLALAGSQLRKQLATLRRGTTNPGAQVTDSALVALGTVLVFVPGLVTTAVGLLMLVPLTRSAVRPLAAGLAARGVARHVTFITPRRDYIDGEVIDVHDAPGTWTPTRPAIRPQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIZ9</accession>
    <name>A0A132PIZ9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_21105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852191.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06470"/>
    <dbReference type="EnsemblBacteria" id="KWX22329">
        <property type="protein sequence ID" value="KWX22329"/>
        <property type="gene ID" value="AFM11_21105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1568"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031326">
        <property type="term" value="P:regulation of cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="386"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="523" mass="54785" checksum="D6B9DDE536518EB5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJB5</accession>
    <name>A0A132PJB5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc metalloprotease Rip1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">S2P endopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Site-2-type intramembrane protease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_21605</name>
        <name evidence="15" type="ORF">AWC31_04410</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852379.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04410"/>
    <dbReference type="EnsemblBacteria" id="KWX22102">
        <property type="protein sequence ID" value="KWX22102"/>
        <property type="gene ID" value="AFM11_21605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10544">
        <property type="protein sequence ID" value="ORX10544"/>
        <property type="gene ID" value="AWC31_04410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1669"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="112"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX22102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX10544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="406" mass="43136" checksum="052802C68B246E59" modified="2016-06-08" version="1">MMFAIGIALFALAILVSVALHECGHMWVARATGMKVRRYFVGFGPTLWSTRRPNRLGETEYGIKAIPLGGFCDIAGMTSVEELKPEDRPYAMYRQKVWKRVAVLFAGPAMNFIIGLVLVYGIAIVWGLPNLNQPTTAIVGETGCVASQISIDKMGECTGPGPAAQAGIQAGDEIVKVGDTEVSDFPSMAAAIRKLDGPVPIELKRDGQTITTVVDVTQTQRFTSADSKEPTTVGAIGVAAPEAQPPTQYNPLTAVPATFAFTGDLAVELGKALAKIPTKIGALVEAIGGGERDKETPISVVGASIIGGETVDAGLWVMFWFFLAQLNFVLGAVNLVPLLPFDGGHIAVATYEKIRNMIRAARGKVAAGPVDYLKLMPATYVVLVVVVGYMLLTVTADLVNPLSIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJP5</accession>
    <name>A0A132PJP5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851498.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22395"/>
    <dbReference type="EnsemblBacteria" id="KWX22555">
        <property type="protein sequence ID" value="KWX22555"/>
        <property type="gene ID" value="AFM11_18700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1077"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="322" mass="32937" checksum="4F98A97204378CE1" modified="2016-06-08" version="1">MYAIVAAADGQLTWENVADITAANSEILIKVHTAGINRADLLQAAGKYPPPPGASDIIGLEVSGTIAALGDGVTGWSIGQPVCALLAGGGYAEYVSVPAAQVLPIPDGVSLRDAAGLPEVACTVWSNLVMTAGLSAGHLVLLHGGASGIGTHAIQVARAIGARVAVTAGSADKLDLCRDLGAEITINYRDEDFVERLRAENGADVILDIMGAAYLDRNVDALAVGGRLVIIGMQGGITAELNIAKLLAKRAGVIATSLRPRPVDGPGGKGEIVAAVRENVWPLIAEGRVKPIIGAELPIEQAQRAHELLASGEVSGKILLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJW2</accession>
    <name>A0A132PJW2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851920.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11510"/>
    <dbReference type="EnsemblBacteria" id="KWX22477">
        <property type="protein sequence ID" value="KWX22477"/>
        <property type="gene ID" value="AFM11_20205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1376"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="264" mass="28236" checksum="7164474F2C5E440E" modified="2016-06-08" version="1">MSFTRAELLAAAERSPQAAGAHDRDGWVGLFADGGQVEDPVGSRPHIGHERIARFYDTFIGPRDITFHRDVDIVDGTTVIRDLELEVAMGSSVTMRIPAYLRYVLRAGTDGPQIAELQAYWELPAMVGQFARNGLGAVPAGLQLTGALLRNQGPAGAVGFASGFRGAGRRGRKLFTGLLADLCAGDEVALRRRLKRDTAVLAGDTAPLTASRLVEQTTGANWRKVIASGHSFVAGLDSGGRRAVLIADLTAKPVAVERLRYFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJY5</accession>
    <name>A0A132PJY5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851940.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11395"/>
    <dbReference type="EnsemblBacteria" id="KWX22497">
        <property type="protein sequence ID" value="KWX22497"/>
        <property type="gene ID" value="AFM11_20320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1397"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453413" evidence="1">
        <location>
            <begin position="31"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="22036" checksum="C836CC83DE76A1CC" modified="2016-06-08" version="1">MSKRILGRVSAVMVAALAAVLASVAGPAAATPNGVPATLPAFVPYQSNWSPNYTVFPYNLWQNRVTPGQITAQRDSCQWFNAQYDTLMGQVFGFQRFLGDQDDEWTAPRVQPAGDIVIANLDQSAGFLDPRAHTLYITNYPDQSQYSPLYNGDSIYRLWYQFTQISDKMKQKLPSGVINANIATANVYGTVIRDSGVCAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK18</accession>
    <name>A0A132PK18_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_20905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06325"/>
    <dbReference type="EnsemblBacteria" id="KWX22362">
        <property type="protein sequence ID" value="KWX22362"/>
        <property type="gene ID" value="AFM11_20905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1522"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPPIV_N" evidence="3">
        <location>
            <begin position="115"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="517"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="731" mass="81244" checksum="A912AE9EB3432FF5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKC4</accession>
    <name>A0A132PKC4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ORF">AFM11_17690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851121.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11810"/>
    <dbReference type="EnsemblBacteria" id="KWX22781">
        <property type="protein sequence ID" value="KWX22781"/>
        <property type="gene ID" value="AFM11_17690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.893"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="29452" checksum="6E6142551C97A303" modified="2016-06-08" version="1">MIFAKGHGTQNDFVVLPDVEARLSLAPAAVAALCDRRRGLGADGVLRVTTAGAALAAGVFDRMPDGVGDGDWYMDYRNADGSIAQMCGNGVRVFAHYLRASGLESADEFVVGSLAGPRPVVLHRSDATIADVTVDMGKANQFGTGTAVVGGRSFTGLAVDVGNPHLACVGISGEELAALDVAGPVSFDPEQFPEGVNIEVLTAAVDGAVSMRVHERGVGETRSCGTGTVAAAVAALAADGADTGTLRVRIPGGEVAVTVTESTSYLRGPSVLVGHGELSEEWWNSAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKI5</accession>
    <name>A0A132PKI5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18190</name>
        <name evidence="3" type="ORF">AWC31_12260</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851290.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12260"/>
    <dbReference type="EnsemblBacteria" id="KWX22859">
        <property type="protein sequence ID" value="KWX22859"/>
        <property type="gene ID" value="AFM11_18190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18758">
        <property type="protein sequence ID" value="ORX18758"/>
        <property type="gene ID" value="AWC31_12260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.995"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453142" evidence="1">
        <location>
            <begin position="27"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="175" mass="18766" checksum="3E3865EFFE3DCCD5" modified="2016-06-08" version="1">MPRWFALMVSVLTVAAGLLAAPSAAADATPIGRIGETLRVDFKGIVADVTVHDVLASEVPPGWGWNGSPRWRAQGSPWRAPVTITTIEAPNPYVMALAFTFNGVTPYADAYPPKHTDAPNALEDALRNAPPGATVSGDVYWDVYRALVTNVVLVNTKTGEHLAQWNLWQPGTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKJ0</accession>
    <name>A0A132PKJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_17585</name>
        <name evidence="5" type="ORF">AWC31_05105</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851086.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05105"/>
    <dbReference type="EnsemblBacteria" id="KWX22764">
        <property type="protein sequence ID" value="KWX22764"/>
        <property type="gene ID" value="AFM11_17585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10661">
        <property type="protein sequence ID" value="ORX10661"/>
        <property type="gene ID" value="AWC31_05105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.872"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX10661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="271" mass="29474" checksum="40D305E734E21CE3" modified="2016-06-08" version="1">MANPFVKAWKYLMALFSSKVDEYADPKVQIQQAIEDAQRQHQALTQQAAQVIGNQRQLEMRLNRQLADIEKLQVNVRQALTLADQATAAGDAAKATEYNNAAEAFAAQLVTAEQSVEDLKGLHDQALQAASQAKKAVEQNAMMLQQKIAERTKLLSQLEQAKMQEQVSSSLRSMSELAAPGNTPSLDEVRDKIERRYANAIGQAELAQNSVQGRMMEVQQASVQMAGHSRLEQIRASMRGEALPSGGATPATPATPATNQTPAAPENPLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKL2</accession>
    <name>A0A132PKL2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851352.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22885">
        <property type="protein sequence ID" value="KWX22885"/>
        <property type="gene ID" value="AFM11_18510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1036"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="210" mass="22927" checksum="DD92CF7820F9373F" modified="2016-06-08" version="1">MKFLLLTLIAHHPDPITGEKKSPAERLRAVIDAAVLAEELGFDGFAVGERHEDPFISSSPPVVLSNIAARTSTIGLFTAVTTLSLLDPVRAFEDYSTLDNLSGGRLELIRLTFARRAGLPVVFESIEDFIDRSSALIGSPQQVIDKVGRYHEQLGHEVIHLSADTDGVTAAQKRQSLELFQADVAPVLREKIPSRPLAAQHHVKEGAYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKU9</accession>
    <name>A0A132PKU9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851325.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22874">
        <property type="protein sequence ID" value="KWX22874"/>
        <property type="gene ID" value="AFM11_18420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1022"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="155" mass="16979" checksum="507E0979174D7A92" modified="2016-06-08" version="1">MPKRSPWASYHKRQRQIDSKVFDIVLSASHPCTCSHVQGFHWNTDDGENLGNCADAECPCEAFDEDTFAAAQLAAGVLPITAAAAVEQDDGEDDALRRAMRAEEQGKVSADEAWDRALHADRPRPTGKPRRYMLDDPAAMDALRQLGGNPEDLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL50</accession>
    <name>A0A132PL50_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_16775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850750.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01345"/>
    <dbReference type="EnsemblBacteria" id="KWX23023">
        <property type="protein sequence ID" value="KWX23023"/>
        <property type="gene ID" value="AFM11_16775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.708"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="92"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="289" mass="31110" checksum="CEEACCF54C1B5F23" modified="2016-06-08" version="1">MTATVAAPQGTASPDAPAIVERDYRPSAASGQPRRSVTRTLGVRFIVPILLLVAWQLVFGQGWLSPTVLPGPLTILESYGELWSTGDLQAALPISLQRAGLGLLIGGLTGLILGVVAGLWSVAERVYDAPLQMLRTIPFIAMVPLFVVWFGIGEESKVALIVGASIFPVYLNTYHGIRGIDRRLLEVAQTFELSRTEAIRLIVVPLAMPGILVGWRYAAGTALLALVAAEQINTTSGIGYILNTANQFQRTDIILAGILVYAALGIVVDVIMRLLEHLLLPWRSTHDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLD1</accession>
    <name>A0A132PLD1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850669.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22987">
        <property type="protein sequence ID" value="KWX22987"/>
        <property type="gene ID" value="AFM11_16565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.662"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="31195" checksum="E7330C661262ECD5" modified="2016-06-08" version="1">MKVADVTLHRPRTVDEAVRTLSACGDNAKILAGGQSLLPIMNMRFAEPSDLIDITAITDLRQYHDHGDHIAYGATVTHMMVENGLVPDAGGGLLNRAAAGIGYRAIRNRGTIGGSLAHSDSSAEWPTILSSLGARVTATSVRGSREIPLSELLLGFFTTSLEWDEIITAVQVPRVSPDRMWALHKTNRKTGEFAESLAVGTFALGFDDTVAEPRLWLGAARDVPIRLSGTEEAVVGRRPDTLTVTDLLGPVAADIAASPESADPAERHRLQLHAVTVQRALLNARRVGTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLK7</accession>
    <name>A0A132PLK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid adenylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_15545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850270.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16240"/>
    <dbReference type="EnsemblBacteria" id="KWX23235">
        <property type="protein sequence ID" value="KWX23235"/>
        <property type="gene ID" value="AFM11_15545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7225"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012728">
        <property type="entry name" value="NRPS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02353">
        <property type="entry name" value="NRPS_term_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="833"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="882"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1080"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1106"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="506"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1308" mass="138500" checksum="3442AFF3BE20A3AD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM71</accession>
    <name>A0A132PM71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_14005</name>
        <name evidence="7" type="ORF">AWC31_09465</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849675.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09465"/>
    <dbReference type="EnsemblBacteria" id="KWX23403">
        <property type="protein sequence ID" value="KWX23403"/>
        <property type="gene ID" value="AFM11_14005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09171">
        <property type="protein sequence ID" value="ORX09171"/>
        <property type="gene ID" value="AWC31_09465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6905"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX09171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="227" mass="25328" checksum="2E8F3A199F07ADA2" modified="2016-06-08" version="1">MSSDADAGRGRTAAANNGTSRRDELLTVAAKLFAARGYHGTRMDDVAEAVGLNKATVYHYYSSKSLILYDIYKSAADFTVEALHDDPTATARETIYHFTRRLLVGIANDLERAAVYFQEGPYIAEWFTEEQVAYIRRAETTVYEHVRDVIDRGIASGEFHDCDSHVLALGYIGMTLGAYRWLRPHGRRTAEEIAVEFSTALLRGLIRDEAVRTDSPLGIDIETGQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PME5</accession>
    <name>A0A132PME5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23511">
        <property type="protein sequence ID" value="KWX23511"/>
        <property type="gene ID" value="AFM11_14675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7044"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="433" mass="41479" checksum="49D3A1A093870628" modified="2016-06-08" version="1">MTGSGDFTAQFAGQLPGFDASAVIAAQEHGLAEYLNLPVQEILARLGFPPLPTAPPPGPLPPEGVPPPSAPASPMDPGQLIKPVTDALGTLGDGVFEGLDPTQMFDGVAQAFDSSNSSLASALGDLTGNWEGAGGTAAAAKTATALDNGAALKAQANALRNSLAAAAATVKQAEARLIEIIGEFMATMAAIGPNIIFPWGWAAAIAAATEAVTRATETMAELQAELAAQTAAVTAAGEPVPVTEAPLTTTAVPSQLTSATSSASGGSQGLSSLMSAATKAAQAGTQTATDLASQLSDMASQGTAGTAGSTAAAAGTAARAGHAAGGGGSAGGGAGGGSAGGSGASTLAARSAPPMPPVSEDLGRAVASSARAGATLGAGYGAPMMGAPMAPMAHGGRMAGGDHTAPAFLQTTDHGDEIVGDLGTAAPPVIGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMH9</accession>
    <name>A0A132PMH9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849822.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23474">
        <property type="protein sequence ID" value="KWX23474"/>
        <property type="gene ID" value="AFM11_14430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6995"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="717" mass="78133" checksum="92C8EAC4D1B66954" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMY6</accession>
    <name>A0A132PMY6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C4-dicarboxylate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849051.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03055"/>
    <dbReference type="EnsemblBacteria" id="KWX23663">
        <property type="protein sequence ID" value="KWX23663"/>
        <property type="gene ID" value="AFM11_12735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6637"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011853">
        <property type="entry name" value="TRAP_DctM-Dct_fused"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02123">
        <property type="entry name" value="TRAP_fused"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="2">
        <location>
            <begin position="150"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="676" mass="70685" checksum="4F8FD6F68669B0DB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN76</accession>
    <name>A0A132PN76_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_13385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849359.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03670"/>
    <dbReference type="EnsemblBacteria" id="KWX23765">
        <property type="protein sequence ID" value="KWX23765"/>
        <property type="gene ID" value="AFM11_13385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6771"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="283" mass="31097" checksum="FC04630804C623BF" modified="2016-06-08" version="1">MIKARIRPPSFTVRMLPSAMTVAAICLGLTAVKMALDNRPTEAMAFLAIAAILDALDGRVARMLKATSKMGEEIDSLADAVNFGVAPAFIIYGTLLSQSRVGWIVVLLYAVCIVLRLARFNALLDVDQPAYEKEYFVGMPAPAGAIGAIGPLAAKMQFGDGWWTSEWAVSLWMIGVSLLVVSRIPMRKIHTFAVSPNMVAPLLVLVAIGVAASVFYGYIVIMVIIVAYVIHIPFAVRTKHWVANHPESWDEQPRQRRAARRAIRRAQPHRRSVARLGLRKPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN88</accession>
    <name>A0A132PN88_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_13375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849352.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03660"/>
    <dbReference type="EnsemblBacteria" id="KWX23763">
        <property type="protein sequence ID" value="KWX23763"/>
        <property type="gene ID" value="AFM11_13375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6769"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="179"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="395" mass="40728" checksum="D872942C3B4683DB" modified="2016-06-08" version="1">MRTVEEHQTVVAGLIKSRAPQQLPLSDTLGLVLAADVVAPLSLPGFDNSAMDGYAVVAEDVASATPDAPVRLPVAEDIPAGRTDPLTLKPGTAHRIMTGAPLPTGATAVVPVEATDAATDTVAIRAAAKPGQHIRRAGEDVTAGTAVLHTGQVVTPAALGLAAALGLAELTVLPRQRVLVMSTGTELVAPGSPLQPGQIYESNAVMLSAAIRDAGAEVLAAPMSGDDVDTFRAILAEHARDADLIITTGGVSAGAYEVVKDSLADQVEFVKVAMQPGMPQGSGTVDGVPIVTLPGNPVSALVSFEVFVREPLRAAMGHRGPGRPRRTAVLTENLTSPRGKRQFRRGVLSGDTVTSYGPPASHHLRWLASANCLLEIDEDVTELAAGSPVAVWDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNG8</accession>
    <name>A0A132PNG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03720"/>
    <dbReference type="EnsemblBacteria" id="KWX23888">
        <property type="protein sequence ID" value="KWX23888"/>
        <property type="gene ID" value="AFM11_13435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6781"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="456" mass="49779" checksum="0B1E781B6B2777CD" modified="2016-06-08" version="1">MLACELALGGAKVTVLEERTSAPNITRAFAVHARTLELLDGRGLADELLSRGLPVREVAPPGGATLNLSDLPTRFGMVLIVPQSGTEHLLEERAIELGVEVRRGAEVVGLRQDADSVTVDLAGGQSLDAAYVAGCDGAHSKVRAAVGIDFVGKQYETHILLADVRLSSPPEETLFARTNTEGVVLFVPFGDGWFRAIAWDRLREQAPLSEPVTLDEIRDAFHRIAGQDFGMSDMRWSSRFLSERKQARHYRSGRVFLAGDAAHVHSPLGGQGMNTGLGDAINLGWKLAAAVRGQAPPWLLDSYERERHPVGAAVLRLTDAFNQVVLSSAATRRLRVLVLGTVLRIPRTRRFLAERLSGIGIAYPRSKDEDWLVGRRMADVDCGGTRLYELLRAGKFVLVTAEPVDIGDDDVIHAVDNRPELPDAVLVRPDGYVAWASERLPHADEVRAAIAHWTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNP6</accession>
    <name>A0A132PNP6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848190.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30535"/>
    <dbReference type="EnsemblBacteria" id="KWX23966">
        <property type="protein sequence ID" value="KWX23966"/>
        <property type="gene ID" value="AFM11_11360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6349"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="402" mass="45578" checksum="5B4D58DD5EE568FD" modified="2016-06-08" version="1">MTVTQTRTTSDCPATRDYLPWKDPELRIDPYPFYARAQAEAPVSRDEDGTFVLTKFEDLMHYGRLPSVIIAPEWEKAGGWRILKDMALGHDEPDHTRLRRLTSKWLTPKRIQDWVKITASVTDEILDRVGADGLVDGSALGAEATHVTVCRLLQVPDDEIESVRREMRKAMPVLSAVPDASDFEACEEAHEYMRARTAFLIEHKRANPGDGLLDHLLALQDSGEMSEAEVFATTLFFYFVGHMDASYLISSGLHMFTRRHDIFDAFRAEPDVRQAIVTELVRFDAPEPVITRTTTEDLVIRGVHVPAGSVLRLVMGAANRDPDIFDTPHEFDFRRPPEQSRNLTFSFGSHSCQGRLLAEAEVRVVWERIAARYSRIELAGEPVIKNTDASRHYYTLPLRLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNT8</accession>
    <name>A0A132PNT8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848341.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30390"/>
    <dbReference type="EnsemblBacteria" id="KWX24009">
        <property type="protein sequence ID" value="KWX24009"/>
        <property type="gene ID" value="AFM11_11635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6404"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1117" mass="125093" checksum="391D342F33E1CB19" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP14</accession>
    <name>A0A132PP14_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Monovalent cation/H+ antiporter subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_13440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849380.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03725"/>
    <dbReference type="EnsemblBacteria" id="KWX23772">
        <property type="protein sequence ID" value="KWX23772"/>
        <property type="gene ID" value="AFM11_13440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6782"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="880"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="916"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="10">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="9">
        <location>
            <begin position="127"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="12">
        <location>
            <begin position="607"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="11">
        <location>
            <begin position="812"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX23772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="961" mass="101052" checksum="EE2E7A3AA516D6C9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP35</accession>
    <name>A0A132PP35_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848161.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30590"/>
    <dbReference type="EnsemblBacteria" id="KWX23957">
        <property type="protein sequence ID" value="KWX23957"/>
        <property type="gene ID" value="AFM11_11305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6338"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021315">
        <property type="entry name" value="Gap/Sap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11139">
        <property type="entry name" value="SfLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="217" mass="22430" checksum="4D7D5E6CE9C4731C" modified="2016-06-08" version="1">MWIPLLAMAIAVSLEPFRIGMTVVMLNRPRPLLQLLTFLAGGFAMGTAVGVVVLFLLRPALGSAHFTLPRVQIVVGVVVLVTAAVVAAGVLEPKPGPREPGPLATRARQLLNGRSLWTAGAAGLGIALPSVDYLAALALIVASGAAAATQVGALLLFNVVAFGLVEIPLISFLIAPDRTRATLTALNDWLQARRRRGVAVLLAAVGLVLLAVGFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPH0</accession>
    <name>A0A132PPH0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848603.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09860"/>
    <dbReference type="EnsemblBacteria" id="KWX24097">
        <property type="protein sequence ID" value="KWX24097"/>
        <property type="gene ID" value="AFM11_12115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6502"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="309" mass="32497" checksum="5E4F7ECC03E91D9B" modified="2016-06-08" version="1">MAQISARVSADVTVAVHGRRGVGVSTVAGALAGCGVAVRDSGEISVLVIAEVLKPEDRASLARLRQGGTPVLIVLNKADLAGSGPGGPMATARGRADQLRRLAGVPVVPMVALLAGADPAPHLVRALRVVAAEPADLTSPDAFLRAPHRLPVEVRVELLDALDRFGIAHAALALSRGADADGLPTLLRRLSEVDQVLAALSAVAAPVRYRRMRRALAELRALRSEPAARFLAADETVLAIMGAAVDVVEADGVAVDRGDDRKAHLHRARYWRRYSRGPVNALHRSCGADIARGSLRLLDSSPDHRVIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ14</accession>
    <name>A0A132PQ14_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24364">
        <property type="protein sequence ID" value="KWX24364"/>
        <property type="gene ID" value="AFM11_10355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6108"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="69" mass="7454" checksum="84B63F302A4C8F84" modified="2016-06-08" version="1">MIRHRPLSLLTILSQRRLPSSSQSVSEKLGGLATRPRRRQLCTMSGWPAATKEEVDDGVGSAPPAVVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQB3</accession>
    <name>A0A132PQB3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_07520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845988.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22020"/>
    <dbReference type="EnsemblBacteria" id="KWX24528">
        <property type="protein sequence ID" value="KWX24528"/>
        <property type="gene ID" value="AFM11_07520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5352"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="132"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="236"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="392" mass="42456" checksum="B47D72F9C934F636" modified="2016-06-08" version="1">MSELDEFRATVRDWCDAHVPTDWRAAQTGVNDEEFVTFQKSWFAELHSAGYAVPHWPAEWGGGLRTRGAKGPMPVSQQIVLFQELAAHDAPRLVLAFVGIHHAASTLLAAGTDAQRQRHLPAILDGEIWVQGFSEPEAGSDLAALRTSARADGENFIVNGQKLWASGAVHADWCLLLARTDPDAPKRHGISYFLMDMTTPGIDVRPIRNAVGDSHFCEIFLNDVVVPAANLIGPVNEGWQVAQATLGAERGMTMLELAERLSNAGFRWLVQACSPVADSVVADRLAQFEIELAGLRGLCRDLVERAEAGATGPADASIVKLYYSELLQRMTGFGAEIGGLAAHTVLAKPVSSGWESGAWMLDFIGSWEWTIPGGASEIQRTIIGERGLGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQC9</accession>
    <name>A0A132PQC9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846021.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22090"/>
    <dbReference type="EnsemblBacteria" id="KWX24540">
        <property type="protein sequence ID" value="KWX24540"/>
        <property type="gene ID" value="AFM11_07590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5366"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAP_DH_C" evidence="1">
        <location>
            <begin position="208"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="357" mass="38291" checksum="90AB0C457FF9856D" modified="2016-06-08" version="1">MRRVVQFSTGNVGRHSLRAIIGRPDLKLVGVHAANPDKIGRDAAELCGLSEPTGVVPTNDIDALIALAPDCVVYTALGETRPMEAIEQMSKLLAAGINVVGTSMVWLVTPRQADDWLRVPLEQACQAGNSSLYVNGIDPGYSGDTAVHAALSLVTRAESVTVKEIFDYGNYDDYEYTGTAMGFGATPDDDTPMAFQPGVITSMFGGLVRNLAGHLGVTLDEVRQRYEPWYAENRIECTMMTVEPGQLAGVRFGVEGMRGGVPVITVEHTTRLTPAAAPDWDYPPDGLSGVHRVIVEGEPRIEVSTHLSHPVLDVTDAGCLSTAARAVNAIDWVCRAPAGLVAVEDIPPTELIRGLMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQE6</accession>
    <name>A0A132PQE6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Copper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_07690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846075.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24559">
        <property type="protein sequence ID" value="KWX24559"/>
        <property type="gene ID" value="AFM11_07690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5387"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453241" evidence="3">
        <location>
            <begin position="26"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="65"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="234"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="366"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="500" mass="54883" checksum="5D9A46FD0F840B0D" modified="2016-06-08" version="1">MPSASRRRFLMGLAAAPLALSMSCSAHGRTTAADARRRLPIPPLADSTIDSSGTRHFTLRAAAATTEILAGKSTQTWGYNGSILGPTLRARRGETIAIAFENGLPEPTTVHWHGMHVPAQCDGGPHQTIAPGGRWNPSWTVRQPAATLWYHPHPHGQTEKHIYRGLAGLFIVDEVDPTPALPHDYGVDDIPLLIQDRRFTVSGAFDESDSTDVGLLGDTIVTNGVAGAYLPVRTDRVRLRILNGSGGRLYNLGFGDDREFRVIGSDGGLLAAPVAVRRIHLSPGERVEVIVDMQAGNPVTLRAFPFENHAGLKDSEAAEFGVDDTFDILELRPEGALRSTPDLPEALATLPTPVPSDVAAERSFDLQWFMINGNRMDMNRIDFCPTVDTTEIWTVTNVDNWPHNFHVHDAQFRILDIDGSPPPPELAGYKDTAYTPPGQRIRIAVQFTEYTDPTYPYMFHCHLALHEDQGMMGQFLVLAPNQEPAPMPMDMSGHAMRRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQH1</accession>
    <name>A0A132PQH1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846140.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24430"/>
    <dbReference type="EnsemblBacteria" id="KWX24581">
        <property type="protein sequence ID" value="KWX24581"/>
        <property type="gene ID" value="AFM11_07820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5415"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="370" mass="38871" checksum="4093E911A494E716" modified="2016-06-08" version="1">MTESSGKAPGKLPAFVMLAGTLISLSGLTWDIGWHSDVGPDSFFTLPHLFVYSGGAIAGLTSLAMVLRATAAQRNGQTPDPAVGGRAFKVLGVFAAPIGYLVGGIAAASFLLYGLWDEWWHGLYGFDVTIASPPHQGWLTSICVTMIGTAIVFAAAREHRWGRWGFMTAIAAFGSYASITSTALAEVNLGTTIDWFTVTWITIPLVCVLLGSQVIGRGGAAGTGLVTFLINLVMWSFAEWAVGWYAELQHLSLRDYVVLSFPIDMLLIPEMVCVFGVLVELLLRWKDATAWLLAGCGAAGAIAITWWISSGAQSEGIEGAGPGEHTTDVLLTCVAAGVLAALLGGATWRLGRALRASNTAPAPAAEVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQP0</accession>
    <name>A0A132PQP0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847578.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18775"/>
    <dbReference type="EnsemblBacteria" id="KWX24362">
        <property type="protein sequence ID" value="KWX24362"/>
        <property type="gene ID" value="AFM11_10340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6105"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="120" mass="13299" checksum="259764DBDAF94B66" modified="2016-06-08" version="1">MPELNDTVTAYLNTWNATDETDRKQLLHQHWSPDATYVDPLAEVSGHDEISGTIAAVHTQFPGFVFSLVGEPDSHHRQVRFQWGLGPRDADPLVIGFDVLTTDGDGRIDTVLGFLDKVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQP3</accession>
    <name>A0A132PQP3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_07895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24594">
        <property type="protein sequence ID" value="KWX24594"/>
        <property type="gene ID" value="AFM11_07895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="106" mass="11638" checksum="B21149BC3C1B69C7" modified="2016-06-08" version="1">MGHVEPIRSVLVALDFIGRADLGLPRVLAGLPQGPALPQQVPALVQRHLQRLQSPMLFVLVDLPTLQFGAKLLLFCDESVNFGEDVLIFSHTASLPDYGWSGEYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQR1</accession>
    <name>A0A132PQR1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846229.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24600"/>
    <dbReference type="EnsemblBacteria" id="KWX24614">
        <property type="protein sequence ID" value="KWX24614"/>
        <property type="gene ID" value="AFM11_08000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5450"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="268" mass="27905" checksum="D54095F3E7DBA992" modified="2016-06-08" version="1">MISLGPIGLASSNPFTDDAAVVADEARHAEALGFATLWRSGNLPMLAAAVRATSSIPVATGIIPVVRVPAADVIATHAELERRHPGRFVVGIGGAHGPQPMATLNAYLDELDAAGIDTRVLAALGPNMLALARDRASGAYPYLVTPSYVSAARAALGPDGLLAVLLMVIPVTDRDAARAAAAGPLEFLAGQGGYRRNLLRQGFTETDIDAVSDRLLDGIAAWGSPERIAERIADYHGAGADQVVLRILGVDDMGTWRARLARTLFGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQY0</accession>
    <name>A0A132PQY0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">AFM11_08730</name>
        <name evidence="11" type="ORF">AWC31_13640</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846585.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13640"/>
    <dbReference type="EnsemblBacteria" id="KWX24736">
        <property type="protein sequence ID" value="KWX24736"/>
        <property type="gene ID" value="AFM11_08730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18356">
        <property type="protein sequence ID" value="ORX18356"/>
        <property type="gene ID" value="AWC31_13640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5595"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="11"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX18356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="295" mass="32863" checksum="59357E1554C47C2E" modified="2016-06-08" version="1">MRPALSDYQHLASGKVRELYRIDDQHLLFVASDRISAYDYILDSEIPDKGRILTAMSVFFFDYLDVPNHLGGPPDDPRIPEEVLGRALVVRQLEMLPVECVARGYLTGSGLIDYEKSGSVCGIPLPPGLGEASKFTEPLFTPATKAELGEHDENISFDKVIDLVGPVLANQLRERTLQTYLQGADHALTKGIIIADTKFEFGVDQDGNVVLADEVFTPDSSRYWRAESYRQGVVQESFDKQFVRNWLTSPASGWDRHGGTPPPPLPDEIVTATRDRYIEAYERISGLSFADWIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQY9</accession>
    <name>A0A132PQY9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08810</name>
        <name evidence="3" type="ORF">AWC31_13560</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846625.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13560"/>
    <dbReference type="EnsemblBacteria" id="KWX24749">
        <property type="protein sequence ID" value="KWX24749"/>
        <property type="gene ID" value="AFM11_08810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18342">
        <property type="protein sequence ID" value="ORX18342"/>
        <property type="gene ID" value="AWC31_13560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5610"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="147" mass="16253" checksum="55B2882A384D3324" modified="2016-06-08" version="1">MDELRRKGLEKMNEVYGWEMPNIEGDPYFDLTVDHLFGTIWTKPGLSMREKRLMTLSAVTAVGSQDLAEIQVNAALLNGEFTEEELKDIAIFLTQYLGFPLGSALNGTVSKVAAKRRKAAEKGEAEDRLANVNAAVKMNTGTTLDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR23</accession>
    <name>A0A132PR23_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha,alpha-trehalose-phosphate synthase (ADP-forming)</fullName>
            <ecNumber evidence="6">2.4.1.347</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_08965</name>
        <name evidence="8" type="ORF">AWC31_13405</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ADP-alpha-D-glucose + D-glucose 6-phosphate = ADP + alpha,alpha-trehalose 6-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53880"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.347"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>CDP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + CDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53884"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:137927"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glucose 6-phosphate + GDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:62230"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate + TDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + TDP</text>
            <dbReference type="Rhea" id="RHEA:53888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:61417"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:137931"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.347" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846708.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13405"/>
    <dbReference type="EnsemblBacteria" id="KWX24776">
        <property type="protein sequence ID" value="KWX24776"/>
        <property type="gene ID" value="AFM11_08965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18314">
        <property type="protein sequence ID" value="ORX18314"/>
        <property type="gene ID" value="AWC31_13405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5643"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX18314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="483" mass="54137" checksum="C6B4A18398839899" modified="2016-06-08" version="1">MSPEGGRNSVSGNSDFVVVANRLPIDMERLPDGSTTWKRSPGGLVTALEPLLRKRRGAWIGWAGIPDSDEEPIVEDGLQLFPVSLSAEDVASYYEGFSNATLWPLYHDLIVKPEYHREWWDSYVDVNRRFAEATARAAAQGATVWIQDYQLQLVPKMLRMLRPDVTIGFFLHIPFPPVELFMQMPWRTEIVEGLLGADLVGFHLPGGAQNFLVLSRRLVGANASRASVGVRSRFGEVHVGFRTVKVGAFPISIDSAELDSKARNRSIRQRARQIRAELGNPRKILLGVDRLDYTKGIDVRLRAFSELLEESRVKRDDTVLVQLATPSRERVESYIAMREDIERQVGHINGEYGEVGHPLVHYIHRPVPRDELIAFFVAADVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRQAYLANPHDLEGVKDAIEAALTQIPEEGKRRMRALRRQVLAHDVDRWARSFLEALASTKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRI6</accession>
    <name>A0A132PRI6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">pyrC</name>
        <name evidence="7" type="ORF">AFM11_05900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845138.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11760"/>
    <dbReference type="EnsemblBacteria" id="KWX24968">
        <property type="protein sequence ID" value="KWX24968"/>
        <property type="gene ID" value="AFM11_05900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4371"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="55"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="329"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="437" mass="45891" checksum="AD40627C13958357" modified="2016-06-08" version="1">MTAQSRGNTVLIRGVRLYGEGDAVDVLVDDGQIAEIGAGLAIPDAAEVIDATGQVLLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTAVFAMANTDPVADTAVVTDHVWNRGQQVGLVDVHPVGAVTVGLEGKQLTEMGLMAAGVGQVRMFSDDGVCVDDPLVMRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPNAAKLGLAGWPRSAEESIVARDAILARDAGARVHICHASTAGTVELLKWAKAQGISITAEVTPHHLLLDDTRLASYDGRNRVNPPLREAGDAEALRRALADGVIDCVATDHAPHAEHEKCCEFSVARPGMLGLQTALSVVVETMVRPGLLDWRGVAKVMSEAPAAIVGLPDQGRPLEVGEPANLTVVDPDATWTVAGTELASRSDNTPFESMELPATVTATLLRGRITARDGKCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRY8</accession>
    <name>A0A132PRY8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845123.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11705"/>
    <dbReference type="EnsemblBacteria" id="KWX24957">
        <property type="protein sequence ID" value="KWX24957"/>
        <property type="gene ID" value="AFM11_05845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4360"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453539" evidence="1">
        <location>
            <begin position="29"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="117"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="472" mass="49257" checksum="604A908132EB01DB" modified="2016-06-08" version="1">MKTALIALTAGLTLATAGCSLDSATQSADTVDVVIGYQSKTINTVTAGTLLRAQGYLERRLGDITASTGTKYNVTWQDYDTGAPITAQMVAEKIDIGSMGDYPMLINGSKTQANERARTEIVSVTGYNPKGALNMVVVTPDSPAQSLRDLAGKKVSASVGSAGHGMLVQALEKSGIDPKTGVEVLNQQPQVGASSLESGQVQALSQFVAWPGLLVHQGKAKLLYDGAELDYPTLHGVVVRRAYAAEHPEVLDAFLQAQLDATDYLNAEPLEAARIVAEASGLPQEVVYLYNGPGGTSFDTTLKPSLVEALKGDVPYLKSIDNFADLDVAGFVQDGPLRAAFAARGQDYDKALNSGANPSVLSGTDAVCNTAVDNPATASELWLDGSDSTTPAATPTCLLKAIREAEGGGSKVRAAYVPDAELGTRWFADKAVWVRAGAEYLPFGTPAGAQRYTAAHPGSVVVDYSQALAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS72</accession>
    <name>A0A132PS72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845621.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25173">
        <property type="protein sequence ID" value="KWX25173"/>
        <property type="gene ID" value="AFM11_07080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4615"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="289" mass="29864" checksum="440B0F98975F8240" modified="2016-06-08" version="1">MSGSESLVFLVSGASRGLGLEIVRAALAAGHRVVAGSRGSSALDELAGDRLVVVPLDVTDDTAVEEAVAAAVDRFGRLDVLVNNAGYANLSAIEDVDLTDFRAQIETNLFGVVRLTQAALPVMRAQRSGRIIQVSSVGGRLATPGLGAYQSAKWAVGGFSSVLAQEVGPLGITVTVLEPGGMRTDWAGSSMAIAPIRPEYAETVGAMATRHGSGEVTAASDPIKVARLVLDVVGLEDPPLRLLVGADAYKYATAAGRDLLAADQKWRALSESTTADDASAAQLDPLGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSA8</accession>
    <name>A0A132PSA8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coproporphyrin III ferrochelatase</fullName>
            <ecNumber evidence="8">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cpfC</name>
        <name evidence="10" type="ORF">AFM11_06550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845339.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29125"/>
    <dbReference type="EnsemblBacteria" id="KWX25077">
        <property type="protein sequence ID" value="KWX25077"/>
        <property type="gene ID" value="AFM11_06550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4505"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="342" mass="37178" checksum="05A53D5EF0D3AAFE" modified="2016-06-08" version="1">MDCSTFDAVLLLSFGGPEGPEQVMPFLENVTRGRGIPTERLAEVAEHYLHFGGVSPINGINRALIEQLRLQVPDLPVYFGNRNWDPYVEDTVAAMRDNGIRRAAVFTTSAWGGYSSCKQYVEDIARARAAVGDGAPELVKLRQYFDHPLLVEMFADAIGAAARSLPDDLRDEARLVFTAHSIPIAADERHGPRLYSRQVGYATRLVAAAAGFEEYDQVWQSRSGPPSIPWLEPDVADHLTALGERGTRAVIVCPIGFVADHIEVVWDLDYELRLQAEAAGIAYVRAATPNADPRFARLAAGLIDELRNGAQPQRVVNPNPVPGYGFSVNGAPCAPQCCGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSB9</accession>
    <name>A0A132PSB9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_07210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845670.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17505"/>
    <dbReference type="EnsemblBacteria" id="KWX25195">
        <property type="protein sequence ID" value="KWX25195"/>
        <property type="gene ID" value="AFM11_07210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4642"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="17"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="377" mass="40522" checksum="64581BDA0AA0B1BC" modified="2016-06-08" version="1">MSTTATATRPTQTAQSLTLTNLVKTYSSRGRESFQAVKGIDMAIEPGELVALLGPSGCGKTTTLRMIAGLETVTSGSIRIGDREVSQLPAAKRGIGVGFESYALYPPMSVRENLLYGLKARKVKGAEEMVASISRRLEMDDMLELRPAGLSSGQKQRVALARALVRNPPVLLLDEPLSHLDASARQRVRRELKVLQREFGYTTIVVTHDQVEALSLADRLAVMDAGVVQQFGTPDEVFDDPANLFVAEFVGEPQINVLPGVARVDNGKTRVEIGSGAGALETTVTGVADGTRVTVGIRPQDCALRTGDGSAGIRTTVAYFEHLLEFGLATTTIAGIEEGIVVQTPAAEDYEPEQQVVVTAPPERVYLFDIESGKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSL2</accession>
    <name>A0A132PSL2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843860.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25300">
        <property type="protein sequence ID" value="KWX25300"/>
        <property type="gene ID" value="AFM11_03135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2499"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="352" mass="39058" checksum="E97297F8107D7047" modified="2016-06-08" version="1">MRHYGVVYDVGLRFDPDRLSVEPYDQQLVDHDMRVIAEQLHANAVRIEGEDIPRLVTASQSAHKMGLSVYFNPWKMNAGIDDTRDYLVEAATAAEQLRQSGVDIVFVTSCEFSIFCDGIYPGSTVLERVAWMAGHMYTAPGESMAEAAEVMAEKAVELNAALRSFVQTTRAHFAGPVTYSAGAWEDVDWTVFDIVGVDYYRQGETEEAYRDGLRALNKYEKPVAVMEFGCCAYEGAAVRGGGGFMVLKGVNDDGSGDFEGDQVPVRSEAEQADYIAEQFDVFATENVHTAFVYVFSFPQYRYGDGARDLDMVSFSLVKTLPSGDPRSKAMPPWQPKLAFTRVAELFASHQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PST4</accession>
    <name>A0A132PST4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_03285</name>
        <name evidence="7" type="ORF">AWC31_21800</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843929.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21800"/>
    <dbReference type="EnsemblBacteria" id="KWX25324">
        <property type="protein sequence ID" value="KWX25324"/>
        <property type="gene ID" value="AFM11_03285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16653">
        <property type="protein sequence ID" value="ORX16653"/>
        <property type="gene ID" value="AWC31_21800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2532"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX16653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="359" mass="38960" checksum="1E2A5E1A15E3EEBA" modified="2016-06-08" version="1">MAAITYRNASCIYEGSDKLAVDSLNLDIADGEFVVLVGPSGSGKSTALRMLAGLEDIDEGNIEIGGRDMVGVPSKDRDIAMVFQNYALYPNKTVAENMGFALKLRGVPAAERRRKVEEAAKLLDLEPFLDRKPAKLSGGQRQRVAMGRAIVREPQVFCMDEPLSNLDAKLRVQTRTQIAALQRRLGTTTVYVTHDQVEAMTMGDRVAVLRNGKLQQFASPTDLYNKPANAFVAGFIGSPAMNLVTGPIVADGVRIGDDATLRLERDQLTLLHEAGLETVTVGVRPEHLSVSDSGGIDVVIDLIEDLGSEIYLYTHAGPDVQIVARALSRGPIKLADSIELRKTPEGVVHMFHPESGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT64</accession>
    <name>A0A132PT64_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ArsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844386.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21015"/>
    <dbReference type="EnsemblBacteria" id="KWX25454">
        <property type="protein sequence ID" value="KWX25454"/>
        <property type="gene ID" value="AFM11_04140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2706"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03034">
        <property type="entry name" value="ArsC_ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006659">
        <property type="entry name" value="Arsenate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00014">
        <property type="entry name" value="arsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="115" mass="12876" checksum="348AEE72C4B2A7B4" modified="2016-06-08" version="1">MASEATIYHNPKCSTSRKTLELLRDNGFEPEVVQYLKTPPTRPELQKMIADAGIDVRTAVRKRESLYAELGLADASDDELLDAMVEHPILIERPFVVTAKGTRLARPIDSVQEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT83</accession>
    <name>A0A132PT83_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_04720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844604.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20425"/>
    <dbReference type="EnsemblBacteria" id="KWX25546">
        <property type="protein sequence ID" value="KWX25546"/>
        <property type="gene ID" value="AFM11_04720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2825"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="21"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="572" mass="58320" checksum="0F6D8D37C42363CF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTC6</accession>
    <name>A0A132PTC6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25302">
        <property type="protein sequence ID" value="KWX25302"/>
        <property type="gene ID" value="AFM11_03160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2506"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453578" description="DUF305 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="44"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="208" mass="22594" checksum="A9C951B88EEE745E" modified="2016-06-08" version="1">MRLKRMLRTAITLLLATALGAAMCAAVIERDPASPPPVLTPLEIGFAQDMTAHHQQAVTMTDMLAVDASPQVRALAEQIRFTQLAEIGQMTGWLQLADAAPAATQPMAWMTEPHSAAHHDGADHSTGMPGMATRDELARLQHATGRDNETLFLQLMTRHHQGGITMAAYAFQHAANDAVRRAATIMVSEQTDEIQIMGVMLDPVRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTK3</accession>
    <name>A0A132PTK3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25650">
        <property type="protein sequence ID" value="KWX25650"/>
        <property type="gene ID" value="AFM11_02995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2467"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="104" mass="8821" checksum="A472071B7AC52276" modified="2016-06-08" version="1">MSALPIAASAGVAGADPGPGWGAPGPGILPGPGLGGFGGPASGLGLLPGAGLGAPGPGLLPGPGVGAPGVGVLPGPGLGGFGGPASGLGLLPGAGFGLPGPGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTN8</accession>
    <name>A0A132PTN8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_04680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844932.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20465"/>
    <dbReference type="EnsemblBacteria" id="KWX25709">
        <property type="protein sequence ID" value="KWX25709"/>
        <property type="gene ID" value="AFM11_04680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2815"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="270"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="396" mass="42056" checksum="DD2D8667F42B13FC" modified="2016-06-08" version="1">MVNKVFVVGVGMTKFEKPGRREGWDYPQMANESGTKALADAGIDYSQVQAGYVGYVAGDSTSGQRALYELGMTGIPIVNVNNNCSTGSTALYLAAQSIRGGLADCAIALGFEKMQPGSLGGGAEDRESPMARHVKAMAEIDEFGFPVAPWMFGAAGREHMKQYGSTAEHFAKIGYKNHKHSVNNPYAQFQDEYTLDDILGARMISDPLTKLQCSPTSDGSGAAILVSEAFVDKHGLAGQAVEIVGQSMTTDFASTFDGTAKNLIGYDMNVKAAQQVYDQSSLGPEDFQVIELHDCFSANELLLYEALGLCGEGEAPALIDKDDTTYGGRWVVNPSGGLISKGHPLGATGLAQCAELTWQLRGTADKRQVDGVTAALQHNIGLGGAAVVTAYQRAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTQ0</accession>
    <name>A0A132PTQ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844809.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20035"/>
    <dbReference type="EnsemblBacteria" id="KWX25644">
        <property type="protein sequence ID" value="KWX25644"/>
        <property type="gene ID" value="AFM11_05305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2947"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="287" mass="31224" checksum="CD49BB563145D455" modified="2016-06-08" version="1">MSTANSQSQTVTFRGVDDLNLVGDEWNKGAESAADRPTVLLLHGGGQNRHSWKNTGQILANRGLHVIALDSRGHGDSDRSPSANYSVEALCGDILQVLYQVGRPVVLIGASMGGLTGILAAHEAGPELVTKLVLVDVVPRFEKSGSARIRDFMFNHVHGFDSLEQAAEAVAAYLPHRTKPRSPEGLKKNLRLRDGRWYWHWDPAFLTKPEDDPFVRVEKLEQAAMNLTIPILLIRGKLSDVVSAEGVQDFLEKVPAAEFVELSDAGHTAAGDDNDAFSAVVVEFVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTW8</accession>
    <name>A0A132PTW8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_00295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842173.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33405"/>
    <dbReference type="EnsemblBacteria" id="KWX25776">
        <property type="protein sequence ID" value="KWX25776"/>
        <property type="gene ID" value="AFM11_00295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.60"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024195">
        <property type="entry name" value="NUDIX_hydrolase_YfcD_pred"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017340">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017340-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="169" mass="18449" checksum="F9B8084A8ECDA58F" modified="2016-06-08" version="1">MDETVAVYDAGGNVVGAAPRSRVYADGLWHASAGVLVRSSDGRRLYVHRRSDTKTVFAGMHDCLAGGVVDPGESPLQAATRELAEELGITGLNPVPLASAAWDGEWAGSPMRCHLFAYRVTYDGPIRHQASEIADGWWWTDDELADRLAAPDWPFVPDTRVLIPNLLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUE0</accession>
    <name>A0A132PUE0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_01450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842781.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34420"/>
    <dbReference type="EnsemblBacteria" id="KWX25969">
        <property type="protein sequence ID" value="KWX25969"/>
        <property type="gene ID" value="AFM11_01450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.297"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="160"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="30551" checksum="730EF169577CE541" modified="2016-06-08" version="1">MPINPKAIGEKTDPQHFEWTDRDTLLYALGVGAGTDDLAFTTENSHEIEQQVLPTYAVIACSPFAAALKIGTFNFGMLLHGSQEIRLFKPLPPAGKMTVVSEVADIQDKGEGKNAVVMLKGVGTDTDSGDVIAETLTTVVIRGEGGFGGQPGQRPAAPEIPDRAPDARVALPTREDQALIYRLSGDRNPLHSDPWFAKNLAGFPKPILHGLCTYGVAGRALVAELGGGDATKVHAVAARFTSPVFPGETLTTSIWRTEPGRAVFRTEAANPDGSGARLVLEDGAAEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUS6</accession>
    <name>A0A132PUS6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ORF">AFM11_01885</name>
        <name evidence="11" type="ORF">AWC31_34675</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842970.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34675"/>
    <dbReference type="EnsemblBacteria" id="KWX26024">
        <property type="protein sequence ID" value="KWX26024"/>
        <property type="gene ID" value="AFM11_01885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11804">
        <property type="protein sequence ID" value="ORX11804"/>
        <property type="gene ID" value="AWC31_34675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.387"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX26024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX11804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="338" mass="36684" checksum="81DB7E6E15DB56F5" modified="2016-06-08" version="1">MTSGSKQVVFSGAQPTSDSLHLGNALGAVTHWAQLQDGYDAFFCVVDLHAITIPQDPETLRRRTLVTAAQYLALGIDPARSTVFVQSHVPEHTQLAWVLGCFTGFGQASRMTQFKDKSQKQGADATTVGLFTYPVLMAADVLLYDTDVVPVGEDQRQHLELARDVAQRINARFPDTFVVPEAMIPKATAKIYDLQDPTAKMSKSAATDAGLISLLDDPKATAKKIRSAVTDSEREIRFDPQAKPGISNLLTIQSAITGTDIEKLVEGYAGRGYGDLKKDTAEVVVEFVTPIKTRVDELLADRAELESILAAGADRAKQVSGKTLARVYDKIGFLQQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUZ0</accession>
    <name>A0A132PUZ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843312.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35305"/>
    <dbReference type="EnsemblBacteria" id="KWX26133">
        <property type="protein sequence ID" value="KWX26133"/>
        <property type="gene ID" value="AFM11_02530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.519"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="114" mass="12419" checksum="4E3E281F86DFF04B" modified="2016-06-08" version="1">MQLSSLLGLQVIDAGHHPVGIVVDVRLGIAGDRADHPPTPRVTGLVISPRTRSSYLGYERTSLDSPALIAAIARWRHRGTFLAAWEDVGRVCADHVTLRPGYRRHSPLLHDGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVC1</accession>
    <name>A0A132PVC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843587.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26224">
        <property type="protein sequence ID" value="KWX26224"/>
        <property type="gene ID" value="AFM11_00945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.195"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="173" mass="18072" checksum="316FA10E5DE3530C" modified="2016-06-08" version="1">MGSTTTDDYDAVARSTAWIADATRSLAGLGATPDDDRAIDPRWGESASALDHLRASIAHHIAALPRQGRPIRSARPGISISHLALSKVLTAQLAEPAAAASAAVADIDVRVDAQKLSAVHIHLVAVGADPRDHTYLHDGDSLRDHAAAAITDLLGVTPHITVTWEDIALPPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVQ8</accession>
    <name>A0A132PVQ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-hydroxyphenylacetate 3-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_01515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843629.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26247">
        <property type="protein sequence ID" value="KWX26247"/>
        <property type="gene ID" value="AFM11_01515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.310"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004925">
        <property type="entry name" value="HpaB/PvcC/4-BUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024719">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024674">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117">
        <property type="entry name" value="PTHR36117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03241">
        <property type="entry name" value="HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11794">
        <property type="entry name" value="HpaB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000331">
        <property type="entry name" value="HpaA_HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpaB_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="HpaB" evidence="2">
        <location>
            <begin position="290"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000331-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="491" mass="54253" checksum="59757D9C105DD7D8" modified="2016-06-08" version="1">MAARTGKEYIAGLRDGREVWIGGQRVSDVTEYEPFAGAVQSVAGLYDLQHDYAGDCLFTHPETGEPTNVSHLIPRSREDIARRGTALAHAARYSVGLLGRSPDYVNVSLAGHAGRSDVWSRNGNEEGAANLVRFQADLARDDLALTHAIIRPTVDKGIGDLAAADGQMALHKVADTADGIVVRGAMVLSTLAPFSDEVAVYPGQPLPKDAHKYAIAFSAPIASPGLRLLCRDAFSTDMAHFDAPFSGRFDEQDAFLIFDDVEIPRSRVFIDGNTEVWNAAMMNGWTANIMQQTTIRAEAKLRFAYELVSRFCKSINASDPRTKELLGELWTYAEMTRALLVAAEAGAREWGNGIWFCDERPFRALRPTLPQWFPRVNEIIKLLGSHNLLATPSEAAFDNPELRPLLDKYLQGANRFDAKERVRLFRAAWDFAGTALGGRNELYERFYLGSAARSYQLDHDVAQFEMSESLVDPLLRIAEAAEKDEQAPAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVS6</accession>
    <name>A0A132PVS6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">AFM11_01810</name>
        <name evidence="10" type="ORF">AWC31_34590</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842928.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34590"/>
    <dbReference type="EnsemblBacteria" id="KWX26267">
        <property type="protein sequence ID" value="KWX26267"/>
        <property type="gene ID" value="AFM11_01810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11789">
        <property type="protein sequence ID" value="ORX11789"/>
        <property type="gene ID" value="AWC31_34590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.372"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="123"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX26267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX11789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="283" mass="29835" checksum="54AD18FF8F300516" modified="2016-06-08" version="1">MGAMTLDGKATRDEIFVDLKQRVAKLTESGRTPGLGTVLVGDDPGSQAYVRGKHADCAKVGINSIRRDLPADITQAQLDDTIDELNANPDCTGYIVQLPLPKHLNENAALERIDPAKDADGLHPTNLGRLVLGKEAPLPCTPRGIVHLLRRFDVPIAGAHVVVIGRGVTVGRPMGLLLTRRSENATVTLCHTGTRDLPALTRQADIIIAAVGVPHMVTADMVKPGAAVVDVGVSRVDGKLTGDVAPDVWDVAGHVSPNPGGVGPLTRAFLLTNVVELEESKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB30</accession>
    <name>A0A132PB30_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859712.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19541">
        <property type="protein sequence ID" value="KWX19541"/>
        <property type="gene ID" value="AFM11_35210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5772"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453164" evidence="1">
        <location>
            <begin position="47"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="185" mass="20464" checksum="FD21227D0E91930B" modified="2016-06-08" version="1">MFIDEAQETSSRDHRANWMQHPAVQRITLALLALVVLMAVPPHAAADSDLTLKDPWTSSCNKDKTAIDKRSMTRDDGFTAGEVTVYYSPSCQTNWLEVYTPIGINDTNRGVGVNMFIGLTTAPWTNDSPEYRYGNHGQLTNEFRTMMIHAPGATCIHYWAGISDYYAAPEGDPLLGTTTDKTICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBP4</accession>
    <name>A0A132PBP4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein AFM11_33930</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33930</name>
        <name evidence="3" type="ORF">AWC31_32540</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858972.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32540"/>
    <dbReference type="EnsemblBacteria" id="KWX19755">
        <property type="protein sequence ID" value="KWX19755"/>
        <property type="gene ID" value="AFM11_33930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11439">
        <property type="protein sequence ID" value="ORX11439"/>
        <property type="gene ID" value="AWC31_32540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5123"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="163" mass="18124" checksum="575F14E02441E395" modified="2016-06-08" version="1">MADSSFDVVSKVDRQEVDNALNQAAKELSTRFDFRGTDTTIAWKGEEVIELTSSTEERVKAAVDVFKEKLVRRDISMKAFDAEDPQPSGKTYKVTGTIKQGISSEQAKKITKIIRDEGPKGVKAQIQGDEIRVSSKKRDDLQAVIALLKGSDLDVALQFVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBR0</accession>
    <name>A0A132PBR0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859421.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17315"/>
    <dbReference type="EnsemblBacteria" id="KWX19687">
        <property type="protein sequence ID" value="KWX19687"/>
        <property type="gene ID" value="AFM11_34480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5241"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="450" mass="46291" checksum="68B4EFD4E63C694C" modified="2016-06-08" version="1">MTIHDPRTGDLVAQLPVAGPSECAAAVARATAASSCWARTPAAERAAALTSAAASVKAAADELAELNERETGKLRQDALGGVEAGAGTLVQYAELGPLHRGRTLHGGWSATDFMVPEPRGVVAVLTPWNDPVAVAAGLLGAALVTGNTVVHKPSERCPKTGRRFAELLGEHLPDGVLEIVDGDGSVGARLADADEIDVVAHVGSSATGRAIAEACARRGAKALLENGGNDALIVDSGVDPAWAAQQAALGAFANAGQICVSVERIFVVADMADAFTDALVGEAREWSGRIGPLVDERQREIVCRHVDDAVSRGARVLAGGEPGSGPGTFYPPTVLADCSTDMLVFQEETFGPVAPVRSVPDFDTALAEAGDDRYGLSAAVLTPDMAHAQEAWRSLPVGTVKINDVFGGAPGGASQPRRASGSGFGFGPELLDEMTAVKVVHWSPPPEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBV3</accession>
    <name>A0A132PBV3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858830.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08075"/>
    <dbReference type="EnsemblBacteria" id="KWX19811">
        <property type="protein sequence ID" value="KWX19811"/>
        <property type="gene ID" value="AFM11_33680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5072"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="168" mass="18753" checksum="7A4192C8C9A58F12" modified="2016-06-08" version="1">MIGREGKLTIEGDLAVLTFERRLPFPVDAVWSAITDPAERRQWMGETTIDAREGGTIETVADGPPVPPEVKKMTGRIRVWDPPNVFEHEWSQPILTDTGCGVVRYELTPDGDGTLLRFSHRGLTVRDGQGFFPGTHAFLDRMEAHLAGEPLPEWGQRYQEVAQSLGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC64</accession>
    <name>A0A132PC64_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_33045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858459.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17180"/>
    <dbReference type="EnsemblBacteria" id="KWX19923">
        <property type="protein sequence ID" value="KWX19923"/>
        <property type="gene ID" value="AFM11_33045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4941"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004707">
        <property type="entry name" value="MmpL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00833">
        <property type="entry name" value="actII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="771"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="796"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="871"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="897"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="229"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="961"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="962"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX19923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="980" mass="106562" checksum="5E49D1B2C9E33493" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCJ4</accession>
    <name>A0A132PCJ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33175</name>
        <name evidence="2" type="ORF">AWC31_17050</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858539.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17050"/>
    <dbReference type="EnsemblBacteria" id="KWX19947">
        <property type="protein sequence ID" value="KWX19947"/>
        <property type="gene ID" value="AFM11_33175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18098">
        <property type="protein sequence ID" value="ORX18098"/>
        <property type="gene ID" value="AWC31_17050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4967"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="294" mass="32285" checksum="734B55D8ABE12E7C" modified="2016-06-08" version="1">MSDKRTTLDEAVSSIRSGMTIGIGGWGSRRKPMAFVRALLRTDVTDLTVVTYGGPDLGLLCSAGKVKRVYYGFVSLDSPPFYDPWFAKARTSGSIEAREMDEGMLRCGLQAAAQRLPFLPIRAGLGSDVRAFWGDELKTVKSPYPTGDGYEELVAMPALTLDAAFVHMNLGDAQGNAAYTGIDPYFDDLFLMAAEKRFLSVERVVATDELVKAVPPQALLINRMMVDTVVEAPNGAHFTTAEPDYKRDEKFQRHYAEAAGSDESWAEFVKTYLSGSEADYQAAVREFKSAQEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCW0</accession>
    <name>A0A132PCW0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M56</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_32085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857882.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31765"/>
    <dbReference type="EnsemblBacteria" id="KWX20181">
        <property type="protein sequence ID" value="KWX20181"/>
        <property type="gene ID" value="AFM11_32085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4743"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="125"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="32660" checksum="29B3F1BB5C6CE714" modified="2016-06-08" version="1">MNAVTFLLVYAVALSWLAPAVLTSPMLTDVHPRLSMSGWLVAVASALFAWSAALVILVVGAVHSLATHTALTFCVETLGITDAVHLSSTVATVLVVVLLTLTAGVALYTARRVIVALLKTRRSNCQHAEAVRIVGRPTEDADVVVITADQPTAYCVSSGRRSAIVLTTGALDLLNPAQLAAVLAHERAHLRGRHHHIVATLNALSAALPRLPLMRAAAHSVPALLEMCADDASTRTYGRAPLLASLVALSTRHRLPDGALAAAGTAVMDRALRLMQPPRTTFWHPQALAMSVVVLATLTAPGLAFMLCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCY5</accession>
    <name>A0A132PCY5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rph</name>
        <name evidence="7" type="ORF">AFM11_32545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858136.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19680"/>
    <dbReference type="EnsemblBacteria" id="KWX20087">
        <property type="protein sequence ID" value="KWX20087"/>
        <property type="gene ID" value="AFM11_32545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4837"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="12"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="161"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="259" mass="27386" checksum="A03AB7D7AA12159A" modified="2016-06-08" version="1">MSRREDGRLDDELRPVVITRGFTTHPAGSVLVEFGQTRVMCTASVTEGVPRWRKGSGQGWLTAEYAMLPAATHDRSDRESVKGRVGGRTQEISRLIGRSLRACIDLGALGENTIAVDCDVLQADGGTRTAAITGAYVALADAVTYLAAAGRLSDPRPLSCAIAAVSVGVVDGRVRVDLPYTEDSRAEVDMNVVATDTGTLVEIQGTGEGATFPRSTLDKLLDAALGACEQLFVLQREALEQPYPGVLPEGPAPKKAFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD21</accession>
    <name>A0A132PD21_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31245</name>
        <name evidence="2" type="ORF">AWC31_25395</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857411.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25395"/>
    <dbReference type="EnsemblBacteria" id="KWX20220">
        <property type="protein sequence ID" value="KWX20220"/>
        <property type="gene ID" value="AFM11_31245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14530">
        <property type="protein sequence ID" value="ORX14530"/>
        <property type="gene ID" value="AWC31_25395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4154"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX14530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="117" mass="12666" checksum="C5C6FAE139BC8FB5" modified="2016-06-08" version="1">MWEFGMLVLLVGALVLLLAPRIMRRRGIGGELANGTLLVTGVSPRPDATGEQFVTITGVINGPTVREHVVYQQMAVDVNEWPTMGSLFPVVYSPKNPDKWAFAPADPPPAPHEPPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD44</accession>
    <name>A0A132PD44_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857498.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25570"/>
    <dbReference type="EnsemblBacteria" id="KWX20249">
        <property type="protein sequence ID" value="KWX20249"/>
        <property type="gene ID" value="AFM11_31415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4189"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="119" mass="13496" checksum="30540A06BFF2AD23" modified="2016-06-08" version="1">MGDERQVRLARVYEQPEPGEGTRVLADRLWPRGMRKTDPRAGTWLPGVAPSTELRRWYDHAPERFDEFAERYAEELSAPAGAAALEELREMLRDGPVTLVTATRELELSHLTVLAKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD62</accession>
    <name>A0A132PD62_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_31560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857574.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26175"/>
    <dbReference type="EnsemblBacteria" id="KWX20273">
        <property type="protein sequence ID" value="KWX20273"/>
        <property type="gene ID" value="AFM11_31560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4217"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="242"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="383" mass="40708" checksum="009F09D7E716ED18" modified="2016-06-08" version="1">MDFNLTKEQELLRDGLSKFLSSRYDLQSSRSAAKLGAGWQPEIWRGFADELGILGATLPEEAGGIGGGPVEAMVIAETLGHALVVEPFVDTVVVAGGLLHRAGTEGAQTLLEDLVAGAAVVALAATEPASGDNWRDVATTARRDGDDWVLNGTKIMAVSAPLATHLLVTARTSGERGDADGISLFLVDLGTAAGGFTAHHYRTVDDRRASDLTFDGLRLAGDALLGEEGRAWPSLDLARDEGAAAVCAEAVGGMRKVLADTVEYCTQRQQFGQPIGTFQALQHRMVDMHMEVEQAAAAVYLAVLNLDAEPAARAKAVSAAKATVGRAARFVGQNAVQLHGGMGMTEELAIGHYFKRLTAMQYEFGSTDYHVTRYAELTRPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDI0</accession>
    <name>A0A132PDI0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_31055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857264.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26765"/>
    <dbReference type="EnsemblBacteria" id="KWX20388">
        <property type="protein sequence ID" value="KWX20388"/>
        <property type="gene ID" value="AFM11_31055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4114"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="11"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="349" mass="37189" checksum="31A655E02F41A1DB" modified="2016-06-08" version="1">MSTVSAYAANSATEPLAKTTIKRREVGPHDVAFDIHFAGICHSDIHTVKGEWGTPNYPVVPGHEIAGVVTEVGSEVTKYKVGDHVGVGCFVDSCRECDNCKAGLEQYCTGTGMIATYNSTERDGTPTFGGYSGATVVDENYVLRIPDSIPLDAAAPLLCAGITTYSPLRHWNAGPGKSVAVIGLGGLGHMAVKLAKAMGAEVTVLSQSLKKMEDGLRLGASHYYATADPDTFKKLRGSFDLILNTVSANLDLGAYLGLLKVDGTLVELGMPEHAMEVPPFPLAGMRRSLSGSMIGGIAETQEMLDFCAEHDALPEIEVIAPDYINEAYERVLASDVRYRFVIDTASLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDQ7</accession>
    <name>A0A132PDQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_30305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20469">
        <property type="protein sequence ID" value="KWX20469"/>
        <property type="gene ID" value="AFM11_30305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3958"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="512" mass="54227" checksum="A209F0C26873546C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDR7</accession>
    <name>A0A132PDR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856885.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00925"/>
    <dbReference type="EnsemblBacteria" id="KWX20479">
        <property type="protein sequence ID" value="KWX20479"/>
        <property type="gene ID" value="AFM11_30370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3972"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="125" mass="13234" checksum="632FD6AC12ECFAC6" modified="2016-06-08" version="1">MTMKSGVVQAPVCGSLDAATALFHSLSDGTRLAILRRLAVGEARVVDLTGELGLAQSTVSAHLACLRDCGLVDFRPQGRASIYRLARPELLEMFRAAEAVLGATGNAVALCPTYGHPTKRKKATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE32</accession>
    <name>A0A132PE32_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_29830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856576.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25170"/>
    <dbReference type="EnsemblBacteria" id="KWX20598">
        <property type="protein sequence ID" value="KWX20598"/>
        <property type="gene ID" value="AFM11_29830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3858"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="450" mass="48573" checksum="54BF0D60CC759A0A" modified="2016-06-08" version="1">MSIPPSADVVIVGAGFAGLSAARELVRLGHKVVVLEGRDRVGGRSSTATVAGVPVDLGGTFVGPTQDAVLALAAELGCQTVPTYSRGKNLIRWHGKVRSYRSTIPRLSILELLDVSRIQWRFERLCRGIRVDEPWSGPQAHKLDKISLERWLRSLHASASTRNLMAIMSRVTWGAEPEAVSMLHAVRYVKAAGGLDRLLDVRGGAQQDRFPEGTQQIAVRMADELGDRVVLKAPVERIERLADGTVAVSCPDGHVSARAVIVAIAPQHRSGIEFDPPLPEHYDKLAAHWPQGSLSKAYAAYDRPYWRANGCSGEALSDEGPVFITFDVSPGDDGPGILLGFTDSRSFDELPPEQRREQALAGFAALFGDAALNPIDYVDHCWGTEEFAPGGPTAAVPPGSWTRYGQWLRRPVDAIYWAGTETADAWTGFLDGAVRSGQRAAAEVAEGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE38</accession>
    <name>A0A132PE38_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_29570</name>
        <name evidence="8" type="ORF">AWC31_24910</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856440.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24910"/>
    <dbReference type="EnsemblBacteria" id="KWX20554">
        <property type="protein sequence ID" value="KWX20554"/>
        <property type="gene ID" value="AFM11_29570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14445">
        <property type="protein sequence ID" value="ORX14445"/>
        <property type="gene ID" value="AWC31_24910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3805"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX14445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="481" mass="50217" checksum="4C816F69F092E81D" modified="2016-06-08" version="1">MTTGPSTGETVTLQRPQPSANVIIALLVGSAFVMILNETIMSVALPALIVDLDIAASTAQWLTSGFLLTMAVVIPMSGSLLQRFPVRGIYLTSMGLFCTGTLVAALAPGFAVLLVGRIVQACGTAVMVPLLMTTVMTLIPAERRGQTMGTISIVIAVAPAIGPTLSGFILGSLNWRWMFWIVLPIALVALTAGLTWLRVDDEKQEPTPIDAVSVPLSAIAFAGLVFGLSLMGESSHGEQSVPAWVPMTVGAVAMVLFGARQVQLQRRDRAFLDLRPFTYRRFSVSLALVILGFMGLFGAIIMVPLYVQDVLGQSALAAGLTSLPGGVLMGLAGPIVGRAYDRHGARLLVVPGSVLLCASLWGFTILSAASPIWELIIVQTIMMVGLSMMFTPLMTDALAVLPDRLYSHGSAILTTLQQVAGAAGTALFVTVMTKASQSGGAPDLPGVHAAFLVAAIISIAAVIAAFFTAPRPSPAGGTPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PET6</accession>
    <name>A0A132PET6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_28405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856330.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20845">
        <property type="protein sequence ID" value="KWX20845"/>
        <property type="gene ID" value="AFM11_28405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3559"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ANTAR" evidence="4">
        <location>
            <begin position="192"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="267" mass="28171" checksum="898EDBC0B06F9778" modified="2016-06-08" version="1">MVKSTGDDEKSKTESRNSVRASAEEADLRAGIADLAGLVAGGRGLSELLTEVATFAVRAIPGADGAGVTLLRVDPVDNMVAALASSAPFVAEIDEIQYMTLNEGPCITAVQERRTVLSGSLGGEKMWPRFGPRVGRLGVHSALSLPLPLADQVVGAINLYARGKDAFDEHAAELGEMFAKPAAVAVHNARILADALTLTVQLQTALATRPVIDQAIGIIRGRTGRSAEDAFAQLRAISQSEHRKLADVAHNIVEEAARRARARHNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEW7</accession>
    <name>A0A132PEW7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855601.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10095"/>
    <dbReference type="EnsemblBacteria" id="KWX20863">
        <property type="protein sequence ID" value="KWX20863"/>
        <property type="gene ID" value="AFM11_27565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3387"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="156" mass="17450" checksum="3EF0F3A2DF5E2CAC" modified="2016-06-08" version="1">MNPDLDLSVERIIRAPRKAVWEAWTSPDSLAQWWIPAPTVCRVERLEVRPGGAFVTRMSDDGGEFVPHLDACFLLVDEFERLVFTNAVDSGWRPANPAPISMTAEVTMYDHADGTDYRVVARHGDPAAKNLHVELGFVEGWSTVANQLARFAESIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEY6</accession>
    <name>A0A132PEY6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855719.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20900">
        <property type="protein sequence ID" value="KWX20900"/>
        <property type="gene ID" value="AFM11_27820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3438"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019268">
        <property type="entry name" value="DUF2278"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10042">
        <property type="entry name" value="DUF2278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="1">
        <location>
            <begin position="232"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="344" mass="36101" checksum="1EFE0FED418B72EE" modified="2016-06-08" version="1">MALNYGVLRARPDRFVREDDDSTPHLQIRAIDDSGQPWRVAVNVQSNDGSEVVFWVVDPLVGHPVLGGLSGLASGFTVRPATSTASLDYVKAPMFDFTLGRALPPSGNANADDLQDLLVLYLNQCKAATGELYAFGAKFDRNLNKPIDAEFGNTDGLHGIHDIHMNQGNVGAHAGDNGAFHDGGLLLAFPDRIVGLFLAFQTQRVPTDAVGAAAPGAQPLSRLIIGQPGVPTPAAAAPAYLERALINPAGADPGAESIVIGNFATTATSLHGWRIVDRNGRETKLDVTLAGGTSAVVVLDGTGVQLGNSGGNLLLVDDQGNQVDSVTYSAADAASVDRYVRFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF31</accession>
    <name>A0A132PF31_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_28140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855865.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10685"/>
    <dbReference type="EnsemblBacteria" id="KWX20946">
        <property type="protein sequence ID" value="KWX20946"/>
        <property type="gene ID" value="AFM11_28140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3503"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="191" mass="20307" checksum="B115E12580931B39" modified="2016-06-08" version="1">MAGPRERMVVSAALLIRERGAHPTAIADVLAHSGAPRGSAYHYFPGGRTQLLCEAIDYASDQVAARLGKAPSALTLLDGLIAGFRKQLLDTDFRAGCPVAAVAVEAGDPDQADTAVVERAGAAFVRWTQLVTQRLEADGVDAARAEELAMLITTSIEGAVVVARATRDVKPLDLIHRQLREQLTTTNGEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFD4</accession>
    <name>A0A132PFD4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-beta hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855991.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10435"/>
    <dbReference type="EnsemblBacteria" id="KWX20984">
        <property type="protein sequence ID" value="KWX20984"/>
        <property type="gene ID" value="AFM11_27915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3457"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="294" mass="30395" checksum="158D6E7982C83B2A" modified="2016-06-08" version="1">MRIFVTGASGFIGSAVVPELVNAGHEVVGLARSDASADALAALGAGVHRGDLTDPDSLRAGAADADGVIHLAFVHDFTDYEQAGETDRVAIEALGAALAGSGRPLVVTSGLAGFPDATEDDAPPPGALRRSEAAAQALVPHGVRVSVVRLPPSVHGEGDHGFVPRLISIAHEKGVAGYPGDGSNRWSAVHRLDAARLFRLALEHAPAGARLQAIADDGIPVREIAEAIGRGLNLPVASIPGDEALDHFGWLGAFFSLDARASSVLTRQRFDWTPTRPGLLADLAEGHYFSSVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFR6</accession>
    <name>A0A132PFR6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26395</name>
        <name evidence="2" type="ORF">AWC31_22920</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854902.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22920"/>
    <dbReference type="EnsemblBacteria" id="KWX21188">
        <property type="protein sequence ID" value="KWX21188"/>
        <property type="gene ID" value="AFM11_26395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15441">
        <property type="protein sequence ID" value="ORX15441"/>
        <property type="gene ID" value="AWC31_22920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3147"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016874">
        <property type="entry name" value="TcmP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028177">
        <property type="entry name" value="Polyketide_synth_Omtfrase_TcmP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX15441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="272" mass="30790" checksum="DFDA1C222CD90AF8" modified="2016-06-08" version="1">MTDKLKVDLSGAPQTMLATFYAKALDAGLPKPILGDRLAKDIADRIDYDWTKTSITAANSPSVTTRSAHFDRWARQFLDVHPQAVVLHLGCGLDGRFFRLQPGPGVEWYDVDYPDVARLREQLYPTHEHYHVVSASVTDPAWLQDIPADRPVLMIGEGLTMYLTEPDGVALLRRIVDRFPSGELQFDAFNSLGIKSQWMNAVVRRSGSTLYWAINKPDDVLRAVPGTRLLAWSSPFDDAAFNEVAWYFRLMAAIMRPVPALRYMAQYHRYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFT5</accession>
    <name>A0A132PFT5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20842">
        <property type="protein sequence ID" value="KWX20842"/>
        <property type="gene ID" value="AFM11_28300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13701">
        <property type="entry name" value="DDE_Tnp_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="12"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="26196" checksum="B5FA70CD968AF0E2" modified="2016-06-08" version="1" fragment="single">MQVSHRFAVSSAVFDDAHLVSCAGLVPVMTLADQTGLSQLLADKIRFTCERIRSAAAHPSPKLTTLIAGMCAGADSIDDLDVVRSGGMKTLFGGVYAPSTIGTLLREFTFGHARQLESVLREHLAALCGRVDLLPGADGRAFIDIDSLLRPVYGHAKQGASYGHTKIAGRQILRKGLSPLITTISTDHGAPVIAGARLRAGKANSGKGAARMIAQAAATARAAGVTGQILVRGDSAYGNSTVVTACHRAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFZ5</accession>
    <name>A0A132PFZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26265</name>
        <name evidence="3" type="ORF">AWC31_23335</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23335"/>
    <dbReference type="EnsemblBacteria" id="KWX21266">
        <property type="protein sequence ID" value="KWX21266"/>
        <property type="gene ID" value="AFM11_26265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15709">
        <property type="protein sequence ID" value="ORX15709"/>
        <property type="gene ID" value="AWC31_23335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3120"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016865">
        <property type="entry name" value="RclC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007339">
        <property type="entry name" value="RclC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40106">
        <property type="entry name" value="PTHR40106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04224">
        <property type="entry name" value="DUF417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028065">
        <property type="entry name" value="UCP028065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="150" mass="15921" checksum="F4964225AD7E0142" modified="2016-06-08" version="1">MNRTDTTLDTVAGLAARYGLVVVIAWFGGLKFMAYEAAGIQPLVAASPFMGWLYEIFSVRAFSSLLGVFELTAAVLLAVKPWWPKVSIGGSLLAILLFLATISFLFTTPGVFEASAGGFPALSVTGGFLIKDVALLGISVWTLTDALRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG00</accession>
    <name>A0A132PG00_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">whiB</name>
        <name evidence="14" type="ORF">AFM11_25500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24780"/>
    <dbReference type="EnsemblBacteria" id="KWX21289">
        <property type="protein sequence ID" value="KWX21289"/>
        <property type="gene ID" value="AFM11_25500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2962"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX21289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="89" mass="9920" checksum="E44DF84460D75060" modified="2016-06-08" version="1">MSVAPVTCEERLPAVPCHIGDPDLWFAESPVELERAKALCTDCPIRRECLSAALERQEPWGVWGGEILDRGTIVARKRPRGRPRKVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG16</accession>
    <name>A0A132PG16_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855140.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22895"/>
    <dbReference type="EnsemblBacteria" id="KWX21271">
        <property type="protein sequence ID" value="KWX21271"/>
        <property type="gene ID" value="AFM11_26420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3153"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="47"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="26581" checksum="AC834426D5A73875" modified="2016-06-08" version="1">MEERGDLPPHGTWTTLEALAAQQHHTEHVDHGRGVHSLRRAPRFAIGHRSYLVQTSAGNLLWDAPSYLDDEILGVVRRLGGVAAIAASHPHMFGAQLSWSREFGGVPVYVNELDAEWIPSPDPLIELWNGEIQPVAGVRLVHVGGHMRGSSVALTADGTLLTGDSISGGLAKNWVSFQRNFPKHVPLSAAVVRRIVDRLDAYDYDRLYTLGGDEIDSAAKDVVHRSADTHIRWVSGEFDHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG21</accession>
    <name>A0A132PG21_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_26590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855152.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22745"/>
    <dbReference type="EnsemblBacteria" id="KWX21275">
        <property type="protein sequence ID" value="KWX21275"/>
        <property type="gene ID" value="AFM11_26590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3188"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="235" mass="25119" checksum="3646D45C6B2AE864" modified="2016-06-08" version="1">MLAATLISLGVVFVAELGDKSQLITMTYALRHRWWVVLSGVGIAAFLVHGVSVTIGHFLGLTLPEKPIAFAAAIAFLLFAVWTWREGRSGGDDENVRVAEPRYVLFAVISSFVLAELGDKTMLATVALASDNNWAGVWLGATLGMVLADGVAIAAGALLHTRLPERFLHILASVLFLLFGLWMLFDAALGLRPVAIAVTVTVALSAIGAGLVRLRRKRANESARQSRVESSPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG77</accession>
    <name>A0A132PG77_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854616.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21369">
        <property type="protein sequence ID" value="KWX21369"/>
        <property type="gene ID" value="AFM11_25990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3063"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="131" mass="14338" checksum="1156DCB59ABDA737" modified="2016-06-08" version="1">MKTVTIAFDVDGTLRDNTITDAYVANERIRTLLITLAGMKNTRIMVWSGGGEGYARRAADAMGIVKYVDVYADKGYGGYDAEGRPIFHTDLLPDIAFDDIEECELGALNLIVDEKGFTPGYVPPGDRPSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGB9</accession>
    <name>A0A132PGB9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin biosynthesis-like protein MoeZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_25615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36280"/>
    <dbReference type="EnsemblBacteria" id="KWX21398">
        <property type="protein sequence ID" value="KWX21398"/>
        <property type="gene ID" value="AFM11_25615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2986"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="298"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="390" mass="42223" checksum="F7BF9E29EE9E8982" modified="2016-06-08" version="1">MSLPPLVEPAAELTREEVTRYSRHLIIPDVGVDGQKRLKNAKVLVIGAGGLGSPALLYLAAAGVGTIGIVEFDVVDESNLQRQIIHGQSDVGKSKAQSAKESINEINPLVQVNLHEFRLEPDNAVELFSQYDLILDGTDNFATRYLVNDAAVLAGKPYVWGSIYRFEGQVSVFWEDAPDGLGLNYRDLYPEPPPPGMVPSCAEGGVLGILCASIASVMGTEAIKLITGIGEPLLGRLMVYDALEMSYRTIRIRKDPATPKITELIDYEAFCGVVSDEAAAAAADSTITPRELRELLDSGKPLSLIDVREPVEWDINHIQGAELIPKPSFESGDALAKLQVDRTPVLYCKTGVRSAEVLAIVKKAGFSDAVHLQGGIVAWAKQLEPDMVMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGS3</accession>
    <name>A0A132PGS3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recG</name>
        <name evidence="7" type="ORF">AFM11_25045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27300"/>
    <dbReference type="EnsemblBacteria" id="KWX21558">
        <property type="protein sequence ID" value="KWX21558"/>
        <property type="gene ID" value="AFM11_25045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2370"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="296"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="494"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="735" mass="80753" checksum="7FE286F931613E8E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGV9</accession>
    <name>A0A132PGV9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_24840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854033.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27095"/>
    <dbReference type="EnsemblBacteria" id="KWX21447">
        <property type="protein sequence ID" value="KWX21447"/>
        <property type="gene ID" value="AFM11_24840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2329"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453239" evidence="7">
        <location>
            <begin position="35"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="369" mass="36863" checksum="7A4F3CD11E3EF827" modified="2016-06-08" version="1">MTVMALNPRHPLVVAVAALIASALVGLALSAAAGANPFDVIAALAEGTLGSPFAIGTSLNNAAVLMLVAAGFTIAYRAGLVNVGGEGQLCLGGIAATAVGVSLSDDMPLPIGLALALGAAVLAGAGWAAIPAWLRIRRGTSEIITTLLLNFVGLALVVLMVQEPQLLRQPMTSSETLPQSEPLALSTHLPLLGLPKNPATIAIVLAVILVAAVAITLRHSAIGLRLRAVGLSGGASLRLGVPVDRTAFLGLTTAGGFSGLAGGLLMTTAPFILAEGFSSGFGFSGLVVGLLARGSMAAVAAVSLLFGFLVAGGINLQLAAGVPASTITVVQAVLIILIAGAAWWTTTARSAPRHTRVETAAPRTEEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGW0</accession>
    <name>A0A132PGW0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_25170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854188.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27490"/>
    <dbReference type="EnsemblBacteria" id="KWX21504">
        <property type="protein sequence ID" value="KWX21504"/>
        <property type="gene ID" value="AFM11_25170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2395"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="727" mass="78831" checksum="516E8CE8440C313E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH45</accession>
    <name>A0A132PH45_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853641.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23905"/>
    <dbReference type="EnsemblBacteria" id="KWX21633">
        <property type="protein sequence ID" value="KWX21633"/>
        <property type="gene ID" value="AFM11_24210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2201"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="27084" checksum="431B323A5F39AACC" modified="2016-06-08" version="1">MSEIITASALAGRTAFVTGASSGIGEATALRLASLGAGVAVAARRKSNLDALVERITAAGGRALAVPLDVTDRNAVTAAADYVSAELGRVDLVFANAGVQLISPIDDLKMDDWQRQIDLNITGVMNTIGAFVPHLVDAAAAGRAADLITTSSIAATRVLEKFSVYSGTKAYLSQLTRLLRVELGRKMVRVATIEPGMVDTELPDHVTDPDASRLMADLIKEIDVLSPADVAETVAFIAANPRHINLTEITILPTQQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHC5</accession>
    <name>A0A132PHC5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="12">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cysC</name>
        <name evidence="14" type="ORF">AFM11_23100</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">APS kinase catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="12"/>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853014.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27865"/>
    <dbReference type="EnsemblBacteria" id="KWX21749">
        <property type="protein sequence ID" value="KWX21749"/>
        <property type="gene ID" value="AFM11_23100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1972"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="458"/>
            <end position="465"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX21749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="623" mass="67501" checksum="04BC254EDEB0284E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHG0</accession>
    <name>A0A132PHG0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853857.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23455"/>
    <dbReference type="EnsemblBacteria" id="KWX21704">
        <property type="protein sequence ID" value="KWX21704"/>
        <property type="gene ID" value="AFM11_24665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2294"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453254" evidence="2">
        <location>
            <begin position="32"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="484" mass="48657" checksum="2B93A23DB9BA3521" modified="2016-06-08" version="1">MSVTGWPAKFLAAVLVAVLSAAVALPDPAHAASPYGPQLPDNPHDGPTGTAAMHGDSGASDTTPLRGPGTRHVLTQPIALGAACPTVLIGRDGMPVALCTQVLGRTPRVYLLDKATGIPLASMAVAAGSLLGGVYAYLDAADRMVLVDGDNNLIRVAHTPNKLGLWNLSIVESTPLGAGLPAGDAVTSVAPAYNGKVWYATAGATVGIVDTATGAVTSAALPAGERVDNSIATAPQGTAVVTSHALYLLTEDSAGKPVVKFRVGYDRGSARKPGQLSWGSGSTPTFFGPVTGGDYLSLIDNADNQVHLLVVDAASGALLCTTPVLTSGGPGSENSPIGAGRTVIAASTYGYPYPTVPDGAGPAVPPTAPFVGGMTRVDVRADGSGCDVVWNNTVRSAAVPKLSVADGLIATVTRHNPLGDQFGTSPADTYFYAAVDAASGALVTEQFMSATIAADPIQMAGTTAPDGVLYQGSVTGIQRIVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHH7</accession>
    <name>A0A132PHH7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="3">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuB</name>
        <name evidence="5" type="ORF">AFM11_24920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854074.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27175"/>
    <dbReference type="EnsemblBacteria" id="KWX21462">
        <property type="protein sequence ID" value="KWX21462"/>
        <property type="gene ID" value="AFM11_24920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2345"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01035">
        <property type="entry name" value="LeuB_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023698">
        <property type="entry name" value="LeuB_actb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="4">
        <location>
            <begin position="2"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="336" mass="35379" checksum="D3C587015ED79730" modified="2016-06-08" version="1">MRLAVIAGDGIGPEVIDEAVKVLDTVLPGVEKTEYDLGARRYHATGELLTDNTIEELRGHDAILLGAIGDPSVPSGVLERGLLLKLRFALDHHVNLRPGRLYPGVTGPLVGNPPIDFVVVREGTEGPYTGNGGALRVGTPHEVATEVSVNTAFGVERVVRDAFARAQNRRKHLTLVHKTNVLAFAGSLWSRVVSEVGAEFPDVEVGYQHIDAATIHMVTDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLAASGNIDATRTNPSMFEPVHGSAPDIAGQGIADPTAAVMSVALLLAHVGETDAAARVDKAVGEHLATRGDEKLSTSEVGERIRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHJ0</accession>
    <name>A0A132PHJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853158.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28105"/>
    <dbReference type="EnsemblBacteria" id="KWX21796">
        <property type="protein sequence ID" value="KWX21796"/>
        <property type="gene ID" value="AFM11_23380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2031"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="175" mass="18592" checksum="4128528AFF7B1592" modified="2016-06-08" version="1">MSQPRHAHTTEVTLEVDGTSHRLTVDNRVTLLDALRERLGATAPKKGCDHGQCGSCTVLVDGRRVTTCLTFAVAADGAHVTTAAGLGHGDELHPVAQAFYDEDAFQCGYCTPGQICSAVGMLNEAKSGAPSYVTDDLEVTPVLTDDEIRERMSGNLCRCAAYPNIVTAIERAATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI27</accession>
    <name>A0A132PI27_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LppI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852812.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08500"/>
    <dbReference type="EnsemblBacteria" id="KWX21971">
        <property type="protein sequence ID" value="KWX21971"/>
        <property type="gene ID" value="AFM11_22705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1893"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453371" evidence="2">
        <location>
            <begin position="23"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="230" mass="23466" checksum="69C81EC624CB5AB5" modified="2016-06-08" version="1">MRIAVIIAASVLLAACSPGREAEPTSQPRLSVPTATTHPSAKPSPTTTTSPLPTTAPAAGTPMPQVIKWVEAGKPADAAGFHTATRDGETTDLGDDIAFVAAGTRCATDKLVGGQLSCLVEADGLPDKPSDVEGNWVAGWVDFAGPTVDIGSLRGDPGRFTYGDGAELPAGQALGFGDYRCRADATALVCVNYAHQSAVRFSATGVEPLGCLQPAPPPVGVGRQFSCPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PID7</accession>
    <name>A0A132PID7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04435"/>
    <dbReference type="EnsemblBacteria" id="KWX22105">
        <property type="protein sequence ID" value="KWX22105"/>
        <property type="gene ID" value="AFM11_21630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1674"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="PTHR43782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="298" mass="31095" checksum="C17998ACD91F6BFF" modified="2016-06-08" version="1">MPATELIYVPFNAAGVPTGVARMPQAIQAAGVEQAVAPARSTWITVTEMTTARGPSGLLSEAALSRMVTDSASALRAAWHRRAIPIVIAGDCPILLAPSIAAAMNGREAGLVFIDGHEDAWDPRATPTGEASDCEMGLALGLFSGPQALDLHLPCLRAQHVAILGPRDQAELLEAGQPSLRDRVAVYVDGSDLAARTDVAGIADLVAHSAGTAPGGWWCHVDLDVLATASLPAVDYPQPGGLTWEQLEHVTSACLTVAGCLGASVVIYNPDLDDGRSAGRIADFIAFVRDRLTTARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIQ8</accession>
    <name>A0A132PIQ8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_22215</name>
        <name evidence="11" type="ORF">AWC31_08995</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08995"/>
    <dbReference type="EnsemblBacteria" id="KWX21892">
        <property type="protein sequence ID" value="KWX21892"/>
        <property type="gene ID" value="AFM11_22215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10279">
        <property type="protein sequence ID" value="ORX10279"/>
        <property type="gene ID" value="AWC31_08995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1793"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004377">
        <property type="entry name" value="ABC_transpt_DrrB/DrrC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00025">
        <property type="entry name" value="Mtu_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="4"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX10279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="226" mass="24444" checksum="F4219689E5F249ED" modified="2016-06-08" version="1">MILLVPSLIITLMYFMFQNAPHRPGGPTPFNTACLIMLGVFPLIVMFLITSITMQRERVSGTLERILTTPLRRFDLLAAYGTAFSIAAAAQASLACVVAFWFLGFHTEGSPILVFFIAIINAVLGVGLGLLCSAFARTEFQAVQFMPLVIAPQLLLCGIIVPRAAMPEWLQWISNVLPASYALEALQEVGAYSEPTATAVRDIAVVVGFAVLALCLAAATLRRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIW6</accession>
    <name>A0A132PIW6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_20605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852012.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06020"/>
    <dbReference type="EnsemblBacteria" id="KWX22243">
        <property type="protein sequence ID" value="KWX22243"/>
        <property type="gene ID" value="AFM11_20605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1458"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="15"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX22243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="390" mass="41613" checksum="EE8B81ED7C3BD302" modified="2016-06-08" version="1">MTTRTAPSGQPDLAPVAGRPFGIYIHVPFCATRCGYCDFNTYTPTELGGSNPEGWLAALRVELRMAAARVGAVPVRTVFVGGGTPSLLGSAGLAAVLDAVRDNFELAAGVEVTTEANPESTSPEFFAALRKAGYTRVSLGMQSVAPHVLAVLDRTHSPGRALAAAAEARTAGFEHVNIDLIYGTPGESDDDLRRSVDAAVHAGVDHVSGYALVVEDGTALARRVRRGEIAAPDDDVLAQRYELLDTHLSEAGFEWYEVSNWSRPGGECRHNLGYWDGGEWWGAGPGAHGFLGATRWWNIKHPNAYAQALADGLVPVADFEELDPQARHLEDVMLRLRLRRGLACGDLTAGERARLAGLVADGLVDAAGERVVLTDRGRLLADGVVRTLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ60</accession>
    <name>A0A132PJ60_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852633.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22227">
        <property type="protein sequence ID" value="KWX22227"/>
        <property type="gene ID" value="AFM11_21945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1737"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453335" evidence="2">
        <location>
            <begin position="28"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="171" mass="16818" checksum="8F7F654B8BAE8FC4" modified="2016-06-08" version="1">MPSALTTISRRRALFSAAALALLGATAAACGTTPPPPELADLTAQLDRARADSKLAADAAAALPPQAPAARALTAVADERSAHAQALSDELTRMTGELPASTTAAPTSASPAPTAAPDQAPSVDDVVDALEQSAKSATDLAPRLSGYRAGLVGSIAASCTAAHTVALGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJA6</accession>
    <name>A0A132PJA6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Urease accessory protein UreF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_19900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851862.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28615"/>
    <dbReference type="EnsemblBacteria" id="KWX22420">
        <property type="protein sequence ID" value="KWX22420"/>
        <property type="gene ID" value="AFM11_19900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1314"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="211" mass="21586" checksum="4EDDED4E5416991E" modified="2016-06-08" version="1">MSSLATLLTLADSRLPTGGHVHSGGVEEAVTSGLLTDIPTLHAYLVRRIRSHGLVAASLAVAVHSGALTPDAADAETDARTPAPAARDASRAQGRGLVRLARRVWPGERWAGLGPRPHLAVAAGAAGAAAGLRADQTALSVVYTTMTGSATAAQRLLALDPGDVAAVTFALSALCDSVAREATAGLADLSDPLLDVLAQRHTERERPLFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJC8</accession>
    <name>A0A132PJC8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06430"/>
    <dbReference type="EnsemblBacteria" id="KWX22364">
        <property type="protein sequence ID" value="KWX22364"/>
        <property type="gene ID" value="AFM11_21065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1560"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="384" mass="41088" checksum="0F006E1E7DFB78AD" modified="2016-06-08" version="1">MRVAVVGAGIGGLTAAIALRANGIDATVYEQAHELKALGAGVAIATNGSRILTRLGMGSALAEIAGPVTHYQFRTWRAEPVAGEPSTLSFGDPARTWFLHRGEFQKALADALPPDALKLGRSCVGAREHRDGVQVEFADGTTADADLLVGADGIHSRLQGTVTRATEPVSEGIMAYRGLIPADRLHGIADLDASAMWLGPRQSFLAYPVSAGRFLNIVAFVPTNLTVAESWTAPGDVSELAAAYRGWDPRVSAIIDAMDSTFRWGIYDREPLDRWSSDRITLLGDSAHAVTPHLGQGANQAIEDAITLATVVRGARPDDVAARLRRYEELRMGRTAQVRRQARAAGRIYRSTDLTPREQADELQAILDSVAINTYDAESAALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJJ1</accession>
    <name>A0A132PJJ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_22075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852535.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22182">
        <property type="protein sequence ID" value="KWX22182"/>
        <property type="gene ID" value="AFM11_22075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1763"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="213" mass="23332" checksum="7E94E8EC340BCAA0" modified="2016-06-08" version="1">MSEVVGTRGGRRTQAERSAAMRTRLLDATVECLVTFGYAGTTTQRVAEVAGVTRGAQVHHFRSKEDLVVAAIEHLAEQRAQAAVRDLGRVAANPDAASMVLDYLWESHQGPVFVATLELWVAARTDEVLAAQIERVEPIVTGALVGALAQLVPDRVAQKELRDLAYTAMDALRGILLSSFADRDPTRARKRWDRVCVHLRSMLSDTLRAEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJJ4</accession>
    <name>A0A132PJJ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_20375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22506">
        <property type="protein sequence ID" value="KWX22506"/>
        <property type="gene ID" value="AFM11_20375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1409"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453324" evidence="8">
        <location>
            <begin position="31"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_C" evidence="9">
        <location>
            <begin position="1294"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1455"/>
            <end position="1480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1480" mass="152113" checksum="DBEE4164BF3DD788" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJM3</accession>
    <name>A0A132PJM3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_20425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851984.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22540">
        <property type="protein sequence ID" value="KWX22540"/>
        <property type="gene ID" value="AFM11_20425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1419"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="28493" checksum="FCE920F4F9B9493E" modified="2016-06-08" version="1">MLALTVGLAVFVGIALGLLGGGGSILTVPLLAYVAGMDAKQAIATSLLVVGVTSAVGAFSHARNGRVQWRTGLIFGAAGMAGAYAGGVLARFIPGTVLLIGFAVMMIATAIAMLRGRRDIQATGEAAGRLPIPKIVAEGLVVGLVTGLVGAGGGFLVVPALALLGGLPMPVAVGTSLVVIAMKSFAGLAGYLSSVQIDWALAAAVTVAAVIGALVGARLAAMINPDALRKAFGWFVLAMSSVILAQEIHMTLGLIAGALTAVAAAAVFACGRYANCPLHRDAAPSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJP3</accession>
    <name>A0A132PJP3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_20545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851989.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05960"/>
    <dbReference type="EnsemblBacteria" id="KWX22232">
        <property type="protein sequence ID" value="KWX22232"/>
        <property type="gene ID" value="AFM11_20545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1446"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="3">
        <location>
            <begin position="43"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="2">
        <location>
            <begin position="283"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="671" mass="75031" checksum="FF0728CA324663EB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJW0</accession>
    <name>A0A132PJW0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Elongation factor GreAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851649.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15270"/>
    <dbReference type="EnsemblBacteria" id="KWX22628">
        <property type="protein sequence ID" value="KWX22628"/>
        <property type="gene ID" value="AFM11_19200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1174"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GreA_GreB" evidence="1">
        <location>
            <begin position="72"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="156" mass="16983" checksum="E669BDCA4D00B4C6" modified="2016-06-08" version="1">MTTSQRIWMSPQAHERLQEELSTLRDLIATEAAQDSDENQVAIQRARQARIQHIHDLLLNAVVGEDPPDDGIAEPGMVLTVRYDETGETETFLLGVRGAEYADMEVYSVQSPLGSAILGARPGEQRTYEAPSGALIAVTLLAAMPYGLHQPADLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK37</accession>
    <name>A0A132PK37_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_19180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851642.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15250"/>
    <dbReference type="EnsemblBacteria" id="KWX22624">
        <property type="protein sequence ID" value="KWX22624"/>
        <property type="gene ID" value="AFM11_19180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1170"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="29813" checksum="67C45B518CFA2D7A" modified="2016-06-08" version="1">MAIALPAGTLLRTGRRRWAMPSTSAGLKDWVALSAVGVVTVMALAVPLIAPHDPLLPVGMPLQAPGTHGFVLGSDSVGRDILSRVLYGARASWFAALVVVAVGLVIGGLVGLIAGSVGGWVDGLLMRITDAFLSLPAPVLAIAVVAALGPGFVHTLIAVSIVWWPFYARLVRGEVARLAARPHVEAAKLAGVKPFRLARRHLLPGAVPNALVAASLDIGTLILTLASLSFLGLGQAAPAPELGADTGRNLTYFLQQWWVPVMPGVGVLVLALIANLAGDGLRNLMKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKC6</accession>
    <name>A0A132PKC6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851795.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22325"/>
    <dbReference type="EnsemblBacteria" id="KWX22714">
        <property type="protein sequence ID" value="KWX22714"/>
        <property type="gene ID" value="AFM11_18750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1087"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="302" mass="32408" checksum="5F8312DBAA467E8A" modified="2016-06-08" version="1">MRVLVAGATSVPGIPLLRELISRGHEVIGVTRSAAKTTKISEAGVKPVVADVLDAGQMDAVVGEFTPEVVVSLLTTLPKLGPLRIKDFDPAKELWSRGAGNLVAAAQRAGVRRVVAESVIFAYGYGSTGPDVMDESDPYPGPPPPGGAEVLAALRGMERNVLGSGQKSDTEGIVLRYGAFYGPGVTHDDMFRRLAKWWLLPAMTGNGIVSWVHIDDVARATADALEKGRGGEIYNIVDDRPQSFGDYVRELNAKLNRPRPWPISHRLVRPVAPYAATAFGTTWLPLSNAKAKAELGWTPIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKD9</accession>
    <name>A0A132PKD9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycine/betaine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_19365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCCT transporter (TC 2.A.15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851709.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15450"/>
    <dbReference type="EnsemblBacteria" id="KWX22657">
        <property type="protein sequence ID" value="KWX22657"/>
        <property type="gene ID" value="AFM11_19365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1206"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="528" mass="56716" checksum="114F5BEFB5E86A82" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKE7</accession>
    <name>A0A132PKE7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22819">
        <property type="protein sequence ID" value="KWX22819"/>
        <property type="gene ID" value="AFM11_17925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.940"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="205" mass="22372" checksum="2484BF2809E59279" modified="2016-06-08" version="1">MFSYPTALPLALRSRGTAARVLADLQRTVGNAATSQLLTASPEPSPIVHNGGPSVSLHGDTTAAFDGGTSKWTPKSMKRAKSCTECPEDDPCLHAVGTFNVTYKADVTIKMPDVPDGLTACQERRVRAFLRDVLGPHEREHARRFRTYDGTTTHRIDFTGCGTTALQEHLQDIHDKEEAKRHTDAESLSAAIDPFNKPIDLDCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKF6</accession>
    <name>A0A132PKF6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted alanine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18015</name>
        <name evidence="4" type="ORF">AWC31_12085</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851229.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12085"/>
    <dbReference type="EnsemblBacteria" id="KWX22830">
        <property type="protein sequence ID" value="KWX22830"/>
        <property type="gene ID" value="AFM11_18015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18727">
        <property type="protein sequence ID" value="ORX18727"/>
        <property type="gene ID" value="AWC31_12085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.959"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="2">
        <location>
            <begin position="91"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="216" mass="22700" checksum="B8626CA2D84E1B29" modified="2016-06-08" version="1">MVSQITEGTAFDRHGRPFRRRNFVPSIVLLVALAVVTLMVWIIALNQPADVQQATVCNAPPPATDPATPKLGQQVAGSDMIEVTPAPLADTKIRVLNASGQGGQAGEIAGQLRDLGFAQPEAANDAIYSSVRLECQGQIRFGPTGRAAAAAVWLVAPCTELFQDERPDATVDLALGTEFTELSSSDDINAVLASLRPDATAPADTELLSKIHTGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKK6</accession>
    <name>A0A132PKK6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dut</name>
        <name evidence="7" type="ORF">AFM11_18030</name>
        <name evidence="8" type="ORF">AWC31_12100</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851235.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12100"/>
    <dbReference type="EnsemblBacteria" id="KWX22833">
        <property type="protein sequence ID" value="KWX22833"/>
        <property type="gene ID" value="AFM11_18030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18730">
        <property type="protein sequence ID" value="ORX18730"/>
        <property type="gene ID" value="AWC31_12100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.962"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX18730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="154" mass="15944" checksum="363DF63B295A0858" modified="2016-06-08" version="1">MSNSLAVVRLDRELPMPSRAHDGDAGVDLYSAQDVELAPGQRALVPTGVAVAIPHGMVGLVHPRSGLAARVGLSIVNSPGTIDAGYRGEIKVSLINLDPETPIVVNRGDRIAQLLVQRVELPELVEVTSFDEAGLADTSRGDGGHGSSGGHASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKS2</accession>
    <name>A0A132PKS2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_18495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12495"/>
    <dbReference type="EnsemblBacteria" id="KWX22941">
        <property type="protein sequence ID" value="KWX22941"/>
        <property type="gene ID" value="AFM11_18495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1033"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="272" mass="29636" checksum="4C0CA6A0954BAAB5" modified="2016-06-08" version="1">MPSQGVTPVRSPRRRFRWSSGLFVSSAVGWAGFVLLWYVLIWAGVVKEHYLPPPHEVVKALVEGLLPGGDMRRHVLPSLRRSLVGFGLGIVIGVTLGIAIGWFKPFERIIDSVLQFFRQLSALALFPVFLLFFGLGEPSKYAIVTWAALWPILLTTIAAVKGVEKLQIDAAKSMGASSWFIFTKVVLPASIPRILPGIRLGGAYAITVLVAAEMVGAPAGLGIFTLTMQQTFRIPQMYAGILLLGLLGLAVNYLLVLAERRLTGWQEGITNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKW5</accession>
    <name>A0A132PKW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851222.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12065"/>
    <dbReference type="EnsemblBacteria" id="KWX22827">
        <property type="protein sequence ID" value="KWX22827"/>
        <property type="gene ID" value="AFM11_17995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.955"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453096" evidence="2">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="267" mass="28690" checksum="5A7A9089FF983927" modified="2016-06-08" version="1">MRQRRVLLAVAALFAAISLVVVGCGGSQPDSGSEHTGTDNDELVLSEAENVILKAIKTMFTWSPARDDSPLDGYNRALPLLGGELLDINIELGNSVRVQEWKDAKLEVMADALLVPSEHPKDTPDTVERAVMLTLTATAPDGKLISSITMRVERVVAKKSPEGWRVEDVSFFPEKEIRTQAQICPPGQSNQPPPDGPCVPNPPPPAKHCPDGATVAQDEVCPPPQGGPETKQCPDGTSVPASGPCPQRRRPKRAPRVHRGLRSRSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL31</accession>
    <name>A0A132PL31_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22712">
        <property type="protein sequence ID" value="KWX22712"/>
        <property type="gene ID" value="AFM11_18730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1083"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="137" mass="14851" checksum="6C91B689BE8E2A2D" modified="2016-06-08" version="1">MMRRDLESMNGADPWAVVLRARAPLGAPEDFTTSRYLQAAGTAEAMVVELCMPGGADIGAVSVRSVVGHPSTGRAERDVEITLPRGIERISRDEVFTADQAAGLFETFYRTDTIGEDYVLRPVEGYTADGGHVYPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLR2</accession>
    <name>A0A132PLR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15895</name>
        <name evidence="3" type="ORF">AWC31_16470</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850386.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16470"/>
    <dbReference type="EnsemblBacteria" id="KWX23291">
        <property type="protein sequence ID" value="KWX23291"/>
        <property type="gene ID" value="AFM11_15895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17995">
        <property type="protein sequence ID" value="ORX17995"/>
        <property type="gene ID" value="AWC31_16470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7304"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021517">
        <property type="entry name" value="DUF3180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11377">
        <property type="entry name" value="DUF3180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="158" mass="16562" checksum="76F3E768EE4ACD81" modified="2016-06-08" version="1">MGPTRKRDLTAGAVVVAVLGYLLITLLYRWFPPITVWTGLSLLAVAIAEAGWAFYVRAKINDGEIGVGGGRLHPLAVARSVVIAKASAWVGALVAGWWIGVLVYLLPRRATIRVAGEDTAGVVVAAVSALALAVAGLWLQHCCKSPEEPPENGDAAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM07</accession>
    <name>A0A132PM07_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23380">
        <property type="protein sequence ID" value="KWX23380"/>
        <property type="gene ID" value="AFM11_15835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7292"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="112" mass="11939" checksum="0DBB3C11F6D0E61A" modified="2016-06-08" version="1">MSTIRELGERGIVLRSLREGIDTSNATGRMIAGVLASLAELELELGRERRTAAREARKARGQAIGRPKALDAQKAALAQRMHAAGEPATTIASTLGVSRATVYRVLAQDVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM54</accession>
    <name>A0A132PM54_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">AFM11_15790</name>
        <name evidence="14" type="ORF">AWC31_15975</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850356.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15975"/>
    <dbReference type="EnsemblBacteria" id="KWX23277">
        <property type="protein sequence ID" value="KWX23277"/>
        <property type="gene ID" value="AFM11_15790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17911">
        <property type="protein sequence ID" value="ORX17911"/>
        <property type="gene ID" value="AWC31_15975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7282"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX23277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX17911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="108" mass="12026" checksum="6291FD2C5A10130A" modified="2016-06-08" version="1">MSIPTPTSNLVHSGEAEARIAWVSQARCRQADPDELFVRGAAQRKAAVICRHCPVILECGADALDNRVEFGVWGGMTERQRRALLKQHPEVSSWADFFAAQRKHRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMK1</accession>
    <name>A0A132PMK1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_15040</name>
        <name evidence="2" type="ORF">AWC31_17800</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850024.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23570">
        <property type="protein sequence ID" value="KWX23570"/>
        <property type="gene ID" value="AFM11_15040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17184">
        <property type="protein sequence ID" value="ORX17184"/>
        <property type="gene ID" value="AWC31_17800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7119"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX17184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="105" mass="11615" checksum="102970A0A5D357A5" modified="2016-06-08" version="1">MITHTMLVSFADPIPDEELERFVSDIENAMADTGVVRRFHAQRHIAVDGEQAIPAFIATAVLQFEVSSEADLATLFAAPGASPVIHTWQARRPYRVAWVNHETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMN7</accession>
    <name>A0A132PMN7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_14565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850084.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23599">
        <property type="protein sequence ID" value="KWX23599"/>
        <property type="gene ID" value="AFM11_14565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7022"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="172" mass="19074" checksum="5BF368BE8B8B40EB" modified="2016-06-08" version="1">MDAALKLIANHGVSGTSLQMIADEMGVTKAAVYRQFKTKEEIVIAITEREMSQLEEALEAAEAEGHPGQARDALLDRMIEQAIDRRGTFSIPMFDPVIIRLQAEYEPFQRFIERLYAALLGTEAGVEARFHAAMLSSSISVAVMHPLLADVDGETLRVQLKQMTRRMLGLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNF6</accession>
    <name>A0A132PNF6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_13885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849539.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23845">
        <property type="protein sequence ID" value="KWX23845"/>
        <property type="gene ID" value="AFM11_13885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6873"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="40"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="465" mass="49482" checksum="1EFD19E242281107" modified="2016-06-08" version="1">MTDDLRTALPGRAPTIAKAGPVDVAGRMERLPWCRVQRTLFLVIATAWFFDSIDLGAMTFLLSPISNHFALSAAQTGVLGGASFAGMFVGAIGAGALADRFGRQRVFKYSIAVWGLASVGLAMAWDFESLITFRFLLGIGMGAEFPVAAAILAEFMPASKRGRYAALLEGAWPLGFITAGAVSYVLVATAVGWRGFFVMQAVLAVIALFLRRNLPESPRWLASRGHTALADRTMARLEDAVRAATGSPLPEPAPVHGAHPEILERGGLRALLVTRHRVRTLTVWAVWFCLMTGYYGLTTWIGKLLTDSGLDIAKSIGFVLGMALWGVPGFLSAAYLIERIGRRYCLAGYTVGSGIAAFFYGQSSGTLELIIAGSFLQFFFFGMFSAIFAYTPELFPTRSRAAGVGSSTALGRLGSVFGPLAVPALLSAGGTSLVFTTSAVLFGIGALIVITSLPETKHAVLEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNH3</accession>
    <name>A0A132PNH3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_13275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849307.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03560"/>
    <dbReference type="EnsemblBacteria" id="KWX23747">
        <property type="protein sequence ID" value="KWX23747"/>
        <property type="gene ID" value="AFM11_13275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6748"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="7">
        <location>
            <begin position="14"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="505" mass="54056" checksum="999ED097729BBD9E" modified="2016-06-08" version="1">MTATPEVELPETGTIHNPATGAVAGQVRWTDPADVPRIAAGLRTAQKEWEARGAKGRAKVLARYAVWLGDHRDEIEKLLIAETGKSAVDAAQEVPLLLMILSYYIKTVEKAMEPETRPAPLPFLSIKKIAVHYRPRAVVGIIAPWNYPVANAMMDAIGALAAGCSVLLKPSERTPLTAEVLLRGWLDSGAPEVFALAQGAREVSEAVIDNSDYIQFTGSCATGAKVMERAARRLTPVSLELGGKDPMIVLEDADVELAANAAVWGAMFNAGQTCVSVERVYVLEPVYDQFVSAVVQAVNNLKMGAGEGYDFGAQIDENQVAITERHVKEAIAAGAKALTGGKRPEGPGSFYPPTVLVDVDHSMTCMTEETFGPTLPIMKVSSVEEAVRLANDSQYGLSASVFSKDVDRAKAVALQLDCGAVNVNDVISNLMCTTAPMGGWKTSGIGARFGGIDGVRKFCKQETVVVPRTNVGAGGNYYNNSHKALARMNKLMTKMALARPRRKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNR6</accession>
    <name>A0A132PNR6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_13840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849523.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23837">
        <property type="protein sequence ID" value="KWX23837"/>
        <property type="gene ID" value="AFM11_13840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6864"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="374" mass="40073" checksum="130C60F92A937BD7" modified="2016-06-08" version="1">MDIRVEGLTLRYGEAVAVRNLDLTVGDGESLVLLGESGCGKTSTMRCIAGLERPSAGRITIGGDVLFDGDRNIDRPPHKRNIGMVFQSYAIWPHMTVFENVAFPLTMQRVGKADIARRVRETLELVGLAEFADRGASMLSGGQMQRVALARSVVMQPSVMLLDEPLSNLDARLRHRLRGDLRELQTRLGLTSVYVTHDQEEALALADRIAMMQHGRIVQIGRPNEIYAKPLSASIADFLGVGNILPVQALDSTGVRIADSAVTLSVAPYDGAGELKACIRGEDIAVGDDVESGMNVLEGKLLTKEFLGASATYRVAIADTAELEIIGGKHRQLTAAPGDTVRIGIPADAVQVLPHEVGQSPGQPQTPTPVQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP01</accession>
    <name>A0A132PP01_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848327.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30450"/>
    <dbReference type="EnsemblBacteria" id="KWX24004">
        <property type="protein sequence ID" value="KWX24004"/>
        <property type="gene ID" value="AFM11_11600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6397"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019910">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_4879"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03564">
        <property type="entry name" value="F420_MSMEG_4879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="301" mass="32216" checksum="780949E62A7133DF" modified="2016-06-08" version="1">MQISILSSLSDTGGRSPIDATVQTLAQLRDEGFRRVWMTQMPYEPDLLTVLAVAFREVDGIEVGSGVIPIQNQHPMLLAQRALTLNLISGGRFILGLGMTHQAVTEGMWGIPWDKPVRRLREYLDGLQPLLAGDPADAPGETVTTRGALQIPGAAAPDVYIAALGPQLLKLAGLRTAGTVTWMTGPKTLAEHVAPTLRDAAAGRKVNVVAALPISVTDDVDGARAQAAKQFAMYGQLPSYRAMLDREGYAGPEDAAIIGDETAVAERIRALDGVDEYVGVVFDASPETRARTRALLRRLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP02</accession>
    <name>A0A132PP02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848517.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10020"/>
    <dbReference type="EnsemblBacteria" id="KWX24069">
        <property type="protein sequence ID" value="KWX24069"/>
        <property type="gene ID" value="AFM11_11955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6471"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="231" mass="25141" checksum="7044F5AA203F822D" modified="2016-06-08" version="1">MKPLPKPYVIRTALDTMLADLAEGDPVPAERELAVRFGVARETVRQALHELLVAGRIERRGRGTVVSRPKLTQPLGLQSYTEGALAMGRRPGRLLVTWETVEATTELAAGLDVAPGAPVMHLERILLADDQRIGLESTYLSSARFGHLHDSFDPSTSLYAAIRAGGVDFGSATERIETALASPREATLLESSTAMPMLLLNRRTVDTDGLPVEIVRALYRGDRVAFETLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP09</accession>
    <name>A0A132PP09_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848355.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24014">
        <property type="protein sequence ID" value="KWX24014"/>
        <property type="gene ID" value="AFM11_11660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6409"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="46"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="27530" checksum="F8E0DAC489A0DA2B" modified="2016-06-08" version="1">MSGAESAAALLASWDQQQAAYIADREGRFRIMVELLELACGDSPVVVDLACGPGSLTRRVLDALQNARVVAVDHDPLLLDIAARALRPVYGDRVTVLDADLADENWPALVAGALGGSAPDAFVSTTALHWLMPDTLLRVYSAAVALLGTGGILLNGDHFRFDRRSPALGRFSAAHDEATQRRAHRSGALSWDRWWQAARAQPGAAALAAVRDERFAERPDPPSTAVDFHLSALAQAGFAEVGTVWQLLDDYVVLGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP87</accession>
    <name>A0A132PP87_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11675</name>
        <name evidence="6" type="ORF">AWC31_30350</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848364.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30350"/>
    <dbReference type="EnsemblBacteria" id="KWX24017">
        <property type="protein sequence ID" value="KWX24017"/>
        <property type="gene ID" value="AFM11_11675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12306">
        <property type="protein sequence ID" value="ORX12306"/>
        <property type="gene ID" value="AWC31_30350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6412"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041669">
        <property type="entry name" value="TetR_C_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17918">
        <property type="entry name" value="TetR_C_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX12306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="206" mass="22718" checksum="F280A2EA8952A739" modified="2016-06-08" version="1">MAGGTKRLPRAVREQQMLDAAVQMFSVNGYHETSMDAIAAEAEISKPMLYLYYGSKEELFGACLNRELTRFVDVVRGQIDFTQSPKDLLRNAVRSFLTYIDTNRASWMVLYTQATSSQAFAHTVREGRERIIDLVARLLSTGTRNPQPDSDFEMMAVALVGAGEAIATRVSTGDADVNEAAELMINLFWRGLKGTPSDANPDRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPD3</accession>
    <name>A0A132PPD3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12440</name>
        <name evidence="6" type="ORF">AWC31_09540</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848802.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09540"/>
    <dbReference type="EnsemblBacteria" id="KWX24153">
        <property type="protein sequence ID" value="KWX24153"/>
        <property type="gene ID" value="AFM11_12440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09182">
        <property type="protein sequence ID" value="ORX09182"/>
        <property type="gene ID" value="AWC31_09540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6567"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453467" evidence="2">
        <location>
            <begin position="33"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="48"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="128"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="383" mass="41773" checksum="9A9744672A7F913F" modified="2016-06-08" version="1">MKIRKVSRIGRRIAVLAAAALVLTSCGQWRGVANVPLPGGPGTESGSTTLYVQMPETLALNANSRVRVRDVFVGRVRKIELINWVPTLTIDLQPGIELPKNTLAKIGQTSLLGSQHVELNPPEDPSREMLKSGDTIPLAQSSAYPTIERTLAGISGILTGGGIPNIEVIQTEVFNILNGRADQVREFLNRLDTFTDELNQQRQEINRAIDSTNRLLNIVSQRNDTLDRVLTEFPPLIQHFAETRDLFADAVTALGRLSAAADETLSNTNANLHTNLQNLQRPLKQLSRAAPYLVGALKLLLTVPFNIDNIPKAIRGDFINVSLKLDLTLSSVDNAFLSGTGVSGMLRALEQAWGRDPNTMIPDVRFTPNPHNAPGGPLVERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPN5</accession>
    <name>A0A132PPN5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_09740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847263.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05485"/>
    <dbReference type="EnsemblBacteria" id="KWX24265">
        <property type="protein sequence ID" value="KWX24265"/>
        <property type="gene ID" value="AFM11_09740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5986"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="28997" checksum="05FBCEC7CEB0BC3B" modified="2016-06-08" version="1">MSTTAEAPIAESPSGGEVPLVELRSVGKSYGNIIALKDINLRVGAGEVTGVLGDNGAGKSTLIKIIAGLHKPTEGELLIDGKPTVFESPKDALKAGIATVYQDLAVVPLMPVWRNFFLGNELRKGILKSLDINGMRSTTISELQKMGIDLPDVDAPIGSLSGGQRQCVAIARAIFFGARVLILDEPTAALGVKQSGMVLRYITAAKEQGFGVIFITHNPHHAHMVGDHFVLLNRGRQKLDCTYDEITLEHLTQEMAGGNELEALSHELGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQF3</accession>
    <name>A0A132PQF3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_07660</name>
        <name evidence="2" type="ORF">AWC31_22155</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846059.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22155"/>
    <dbReference type="EnsemblBacteria" id="KWX24553">
        <property type="protein sequence ID" value="KWX24553"/>
        <property type="gene ID" value="AFM11_07660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16715">
        <property type="protein sequence ID" value="ORX16715"/>
        <property type="gene ID" value="AWC31_22155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5381"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX16715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="146" mass="16002" checksum="C6052BA796A48BCA" modified="2016-06-08" version="1">MAKLSVSVEVPLPPEKAWEYASDLSRYHEWLSIHRAWRSKLPETLEKGTVIESIVEVKGMLNRVRWTLVHYKPPEALTLNGDGRGGVKVKLIGKIKPAGEGSTVGFDLHLGGPALFGPIGMVVAAALKSDIQESLNKFKELYAPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQF7</accession>
    <name>A0A132PQF7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_10800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847808.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19315"/>
    <dbReference type="EnsemblBacteria" id="KWX24437">
        <property type="protein sequence ID" value="KWX24437"/>
        <property type="gene ID" value="AFM11_10800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6199"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="373" mass="41834" checksum="8D87EB0B06DDC1CA" modified="2016-06-08" version="1">MTDLHDPAEFRTALRAWLAENDLTPPDDHTLEGHMRQFARVQKALYDGGWSRYGWPEHAGGLGGPEILRAIVGEEVVGRRLAEPGPYSMLEVLAPTMIDYAPAELAAEMVPKLLSGEEQWCQGFSEPGSGSDLASLTTRAVQRGDRWIINGQKVWTSFAQYSHRCILLTRTGDADTRNHEAITAFFVDLDTPGISVRPLRTMHDVDEFCEVYFDDVAVDSGRMLGKPGDGWRLAMDLLPYERSTCFWQRIAYLYSRFDALVGEVKNLGQVVDTDMGEAYLALHTLRCRSRATQHRLADGHKLGPDTSIDKVLLAGAEQRLYDTARDLLPGVIELDDTEWRTEYLYSRAATIYGGTAEVQRNIIARRLLDLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQL0</accession>
    <name>A0A132PQL0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylisocitrate lyase</fullName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847483.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24332">
        <property type="protein sequence ID" value="KWX24332"/>
        <property type="gene ID" value="AFM11_10150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6066"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012695">
        <property type="entry name" value="PrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02317">
        <property type="entry name" value="prpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="305" mass="32635" checksum="9380E68EDCF4CE97" modified="2016-06-08" version="1">MSGLLASAITAAEKRRRLRVALESGRLQRFPGAFSPLVAKLTAEVGFDGVYVSGAVLSADLGLPDIGLTTLTEVCGRGAQIASATDLPTLIDADTGFGEPMNVARTVTLLEDAGLAGLHLEDQVNPKRCGHLDGKSVVDTAEMVKRLRAAVSARRDANLIVCARTDAAGVEGLPAAIERAKAYADAGADLIFTEALRTPTEFEQFRAAVDTPLLANMTEFGKSELLTARQLSDMGYNVVIYPVTTLRLAMHAVEAGLRDIISSGTQAGLVDRMQSRSRLYGLLRYADYNDFDSDIYNFAPQEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQN6</accession>
    <name>A0A132PQN6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00125"/>
    <dbReference type="EnsemblBacteria" id="KWX24648">
        <property type="protein sequence ID" value="KWX24648"/>
        <property type="gene ID" value="AFM11_08200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5491"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="138" mass="15627" checksum="56ED9286916AA62B" modified="2016-06-08" version="1">MQQLLDIADVVKSTGVTTSTLRYYERLELIAPAGRNGLRRLYEPSIVQRLRVIGMLQRAGMTLDEVGQFLDQRRRANHGWRDMIHRKQDELQQQLSVIQAAIDGLTHTLSCPHADLLDCPHVAAALDDGGIWANTERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQV6</accession>
    <name>A0A132PQV6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_08235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846353.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24654">
        <property type="protein sequence ID" value="KWX24654"/>
        <property type="gene ID" value="AFM11_08235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5498"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="58"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="280" mass="29827" checksum="B6456D03191E3BFB" modified="2016-06-08" version="1">MPVKGRWALLLLAPAVLLVAVFFVVPIAAILLRSFTEPQLGLETYRSLLADPTTLRVLGRTMLAGVIAVIVCVLLGYPYAYLMTLVGPTARSLLMVVVLVPFWTSLMARTFAWISLLQRDGPVAALLGFFGMPDVVLLGTSAGVMIGMVQILLPYMVLTLVTSLSQIDRGLLTAAQSLGANRYRAFLQVYLPLSAPGMFAGSGLVFILALGFYITPQLLGSPQESLIAQVIGVRVERLVDFAGAGGLSLILLLATAACLFVGLLAVKPLRNLAGQSGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR01</accession>
    <name>A0A132PR01_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846685.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13450"/>
    <dbReference type="EnsemblBacteria" id="KWX24768">
        <property type="protein sequence ID" value="KWX24768"/>
        <property type="gene ID" value="AFM11_08920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5633"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="230" mass="23573" checksum="81F5BC13147ECCAC" modified="2016-06-08" version="1">MELNNEFRVAVPAAKTWEVLTDVERVAPCLPGATLLSVNGDEFTGAVKVKVGPITVSYQGEAAFQEKDAKAQRVVLKANGKETRGNETASALVTAQLKDEGDATTVVVTTDLAISGKAAQFGRGVLADVAGNLIGQFAKSLEAELIGSAAPAAGTSSTATESGPQEATPINALALAKVMAVPMAKRFAPAIGAVTAAGVVGFLLGRRRAKPAPSPLRPEDLQAALLRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR61</accession>
    <name>A0A132PR61_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polysacc_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_09185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846832.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24813">
        <property type="protein sequence ID" value="KWX24813"/>
        <property type="gene ID" value="AFM11_09185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5686"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="309"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="397" mass="41232" checksum="88FF4ED0A378D4D5" modified="2016-06-08" version="1">MLKALGQVGGARMLATAAQAITMLVMARGLGPSAFAQFAAVLGTLMALIMIADGGATYAVGRHHESVQTVAEVFRANRLLTYGVLAISLPVLAVLAGTTQSTVLAACVPLCFWAPLERQLEVISAYLIARGGQQMVGFGYFVRRMPTLAVVLLVPTGSALVWAFSLSMLVAAIAARLMFARHLSGSGLALPGRALPDRTTWAMLAPFWAALAGQGIRQADVAVLTISAGTPVAGIFAPASRLTPALMLVPWTYTQLLLPRLATTKERLSLVTILVVGALSAAFFVPLAITAPWWIALLLGEAYAPSAAVVRIIVVSLVFAAVASAIASGLNAVDQASLVAAIVWTSSIVTLALIATFGPLFGAVGAAWSVAFGYVLQCSLMGAAYRFKVKPASVVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRG6</accession>
    <name>A0A132PRG6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845046.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="9myco-a0a132prg6">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24920">
        <property type="protein sequence ID" value="KWX24920"/>
        <property type="gene ID" value="AFM11_05625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4315"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="492" mass="53848" checksum="D9D6173FC63CF217" modified="2016-06-08" version="1">MSVVAEHSTIAHTSLGRLRGTLEGGVSVWRGVDYAQQPLGRLRFVAPQPLTPWSDVREAVDHGPLPPQGRSFVGGGRDDPKIRDEACLTVTVWSPDTGGSLPVMVWIPGGAFVYGAGQLQLYNGSRLAANGNVVVVNVTYRLGVFGGFELGDLGEGFDDNLCLRDQIAALQWVRDNIAAFGGDPERVTVFGESAGATSVLALLASPAADGLFARAIAQSPALPLIADREIRARQSRRFMHLLGVGAEQLKVLPQRQLRRAAGQLQLESAQQTPTLAYGLTHGVDLLPLHPIEAARAGKVARVPLIIGTNSHEASMFAWGKPPMLPTTPELVDGYFQRTAPHDRDRILSAYPTYPRRAARVAFGSDVMFGAPTWAFADAYSALAPTNVYRFDHTTWTLRALGLGATHGSEIVHIQHSYSSYLGRKIHPLGRRVQPSVGRRMQRTWLDFATDDLGPEWPRYDSDRRRTRVIRSTRDETVEDPDAVRRAAWEGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRL7</accession>
    <name>A0A132PRL7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845157.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24979">
        <property type="protein sequence ID" value="KWX24979"/>
        <property type="gene ID" value="AFM11_05960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4384"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="496" mass="55984" checksum="933290DB87296C64" modified="2016-06-08" version="1">MTLPDSKPDFHTLIVGAGFSGIGTAIKLDKAGLHDYLIVEAGDGAGGTWYWNTYPGIAVDIPSFSYQFSFEQSRDWSRTYAPGPELRAYADRCVDKYGLRPKIRFNTKVSDAQFDDDASLWRVRLEDGEVLTARYLVNASGVLTIPKLPEIDGVDSFAGTTVHTARWDHTVDLAGKRVAIIGTGASAVQVIPEIAPKVKQLTVFQRTPIWCFPKFDVPIPPVARRLMRLPGGRTLHRLISQAYVEFTFPLAAQYFTINPFAKRAGAAGRAYLRQQVRDPEVRDKLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKIAGSGVATADGEHHDVDVLILATGFKVMDVDALTFDIVGSGGRSLSEFWEQHRMQAYEGVSIPGFPNFFTVMGPYGYVGSSYFALIEAQTHHLVRCVERAERRRARRVEVKREANDRYFAEMMRKRHRQIFWQDSCSLANSYYFDRNGDVPLRPATTFEAYWRSRRFPLDDYAFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRQ5</accession>
    <name>A0A132PRQ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_06095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845193.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25000">
        <property type="protein sequence ID" value="KWX25000"/>
        <property type="gene ID" value="AFM11_06095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4411"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03769">
        <property type="entry name" value="SR_IS607_transposase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041718">
        <property type="entry name" value="IS607_transposase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="50"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="197" mass="21902" checksum="97B311DB7ED012CB" modified="2016-06-08" version="1">MKLAEWARANGVHPQTAYRWFREDRMPVPARRLESGTIWVDAPDIGRTGRTVVYARVSSHDQRPDLDRQVARLADWATSNGHVVGEVVTEVGSGLNGRRPKLRRILSDPSASVVVVEHRDRLARFGVEHLEAALSAQGRRIMVADQGETVDDLVRDMIEVLTSMCARLYGRRGARNRAMRAVTATKQKDPVGVVADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRW9</accession>
    <name>A0A132PRW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08940</name>
        <name evidence="2" type="ORF">AWC31_13430</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846699.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13430"/>
    <dbReference type="EnsemblBacteria" id="KWX24772">
        <property type="protein sequence ID" value="KWX24772"/>
        <property type="gene ID" value="AFM11_08940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18318">
        <property type="protein sequence ID" value="ORX18318"/>
        <property type="gene ID" value="AWC31_13430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5637"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="278" mass="28901" checksum="89629EB05302A170" modified="2016-06-08" version="1">MQLSLADRTYLVTGGGSGIGKGAAAAIVASGGNAMLIGRNADKLSAAADELSAQGPGSVRYEPADVTNEDEVSRAVDAATAWHGRLHGVVHSAGGSETIGPITQIDSELWRRTVDLNVNGTMYLLKHAGREMVRGGGGSFVGISSIASSNVHRWFGAYGVSKAALDHLLMLAADELGPSWVRVNSIRPGLTRTEMVGPIMDVPAVTDDYKACTPLPRFGEVEDIANLAVFLLSDASGWITGQAINVDGGHGLRRGPDISGMLEPLFGADGLRGVVPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS68</accession>
    <name>A0A132PS68_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_06300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845260.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29375"/>
    <dbReference type="EnsemblBacteria" id="KWX25037">
        <property type="protein sequence ID" value="KWX25037"/>
        <property type="gene ID" value="AFM11_06300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4454"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="259" mass="27033" checksum="7029EF71E7BCFFF4" modified="2016-06-08" version="1">MTAQNNIRTAVVTGAGSGIGRAIATTLAERGWRVVVTDIDATAAEQTVAALAGTGHEAVALDVTDPALANSVADDVADRLGLQAWISNAGISAMARFVDVSPGQLDRSLDINLKGVFYCGQAAARAMIRTGVHGTIVNTASMAAKQGRVPFLADYVASKFGVLGLTQAMAYELAEHHITVNSVCPGFVATPMQSRELEWEAELSGSTPDGVRQSWIDATPLGRLQTPDDVARAVAFLVSEDARFITGEALSVNGGAYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSK2</accession>
    <name>A0A132PSK2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_05980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845812.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29680"/>
    <dbReference type="EnsemblBacteria" id="KWX25244">
        <property type="protein sequence ID" value="KWX25244"/>
        <property type="gene ID" value="AFM11_05980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4387"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="YhhN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="PTHR31885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="228" mass="23898" checksum="B297BE12A17CEF56" modified="2016-06-08" version="1">MWVAAAVVAAGYGVFLLVTALRLPAGADLTGQFPGQPAVKALAAVLLAVAASTHPIARERRWLVGALIFSAAGDFLLAMPWWEPSFVLGLAAFLVAHLCFLAALLPLAKRTTPRLVAVTLTVVACLVLLAWFWPRLIEQGMAIPVTAYIAVLGAMVCTALLARLPTAWTALGAVCFAVSDAMIGISEFVRGDQLLAVPIWWAYAGSLLLITAGLFFGRTSAPSATSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSP8</accession>
    <name>A0A132PSP8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844118.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21515"/>
    <dbReference type="EnsemblBacteria" id="KWX25378">
        <property type="protein sequence ID" value="KWX25378"/>
        <property type="gene ID" value="AFM11_03640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2603"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035166">
        <property type="entry name" value="DUF5336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17270">
        <property type="entry name" value="DUF5336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="270" mass="27445" checksum="0DE33BB9C2127064" modified="2016-06-08" version="1">MTYPPSSPGYPPAPQPGSQYGATQQFAKTDVAPGESKLPEILLAVVAAAGLITYLVSFALEAAAGLGALPVLLSLLAGLLAGVSLLPKQKNYVAVVSVIATFALLLAISDLVATGGEAGWALYTILVLTLIQAGSAIAALLFDSGVLTPPAPKPAYEQQPQYGQYGGPSQYYGQQSQPQVGGQPYGQSAPQRPGYPSQYGSYPGSSGFPSQSPQGAPQGGQQSGPPTPPTGFPTYGQPQQQTGSSAPTTQVPAQPQAQQPSSQQSGQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT70</accession>
    <name>A0A132PT70_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844513.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20670"/>
    <dbReference type="EnsemblBacteria" id="KWX25505">
        <property type="protein sequence ID" value="KWX25505"/>
        <property type="gene ID" value="AFM11_04480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2774"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013207">
        <property type="entry name" value="LGFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08310">
        <property type="entry name" value="LGFP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453572" evidence="1">
        <location>
            <begin position="32"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="203" mass="19684" checksum="A9C8AB2C45A80C2F" modified="2016-06-08" version="1">MNAKLMKRTGAVAAALAISGAAAVACSQAEDATKDTLSSASSAASSAVDAGTSAVESGASSASSAVSSAIGGAPSTINAPGVGEVTLDGPTAEAYAKAGGEATLGLPTAQPEKVGDGTVQAFANGTIYSSPSTGAHVVQGEILRVYTENGGPAGQLGFPTTDEAETAGGPDVANGGWISEFQHGTITWLNHGDGTFAETITPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT95</accession>
    <name>A0A132PT95_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844592.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20470"/>
    <dbReference type="EnsemblBacteria" id="KWX25540">
        <property type="protein sequence ID" value="KWX25540"/>
        <property type="gene ID" value="AFM11_04675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2814"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="447"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="542" mass="58885" checksum="57B03ED226105612" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTE9</accession>
    <name>A0A132PTE9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase RecQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_04290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844454.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20865"/>
    <dbReference type="EnsemblBacteria" id="KWX25477">
        <property type="protein sequence ID" value="KWX25477"/>
        <property type="gene ID" value="AFM11_04290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2736"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="224"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="533" mass="58075" checksum="05080B89FF084EFA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTL2</accession>
    <name>A0A132PTL2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21835"/>
    <dbReference type="EnsemblBacteria" id="KWX25660">
        <property type="protein sequence ID" value="KWX25660"/>
        <property type="gene ID" value="AFM11_03250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2525"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="463" mass="47226" checksum="83CFCDD230DB1D28" modified="2016-06-08" version="1">MLHARGPRSGLIDTCGNRGLLRFFSGRFWFARAHIHPPQKGTNVETAARSCLMAGVALVGAGAIAAAPIHPVLPASQAPAIPSSSASVELNALVNPIELWAEVLSTTATNLGSIAQTVLENPAPILGKIIDNQLITAQVFASLASTFASGFADGVGLMPQQIEDSIRAILAGDIYQGSINLATAFLSPIVRGAFGALNQLPNLIAVLQNPFVNTAAVIETAITQGILNVGFPLLTQVLAPVGQIGLTGQAIYDGLQANDFEAVANAIISFPSDMVNTIVNGNTEMGFPGLIGADFGLVPGLLAFGRAIADSIQPPVLTSPPSPSVAPDLNAETVTIDTSEIDGGQNGSADGLAAVSDDAPAQDAAAEDVGTGDLAGDIEGDEESAPPAAEVAVVKNNPLAKLGKLGPDSNRQGRAAAAVKSLGDDVGKAVKKIGDDVKKALGVKPKKEKEKKEQKATADGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTQ4</accession>
    <name>A0A132PTQ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20935"/>
    <dbReference type="EnsemblBacteria" id="KWX25693">
        <property type="protein sequence ID" value="KWX25693"/>
        <property type="gene ID" value="AFM11_04220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2721"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="17"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="314" mass="32698" checksum="32E93EEC86F81B7A" modified="2016-06-08" version="1">MNRVGAIDCGTNSIRLLIADAVDGRLHDVHREMRIVRLGQGVDATGEFAPEALARTESALADYAALMVKHSVSAVRMVATSAARDAGNRDEFFAMTARQLGAVVPGSVAEVITGTEEAELSFRGAVGELDPVEAPFVVVDLGGGSTELVVGKDSVQASFSADIGCVRLTERCLHSDPPTAAEVQAARAVVRDGLAEALRAVPVDGAHTWVGVAGTMTTLSALAQGMTEYDADAIHLSRIGFDDLLRVCDELIGMTKQQRLALGPMHEGRADVIGGGAIIVEELAAVLGDRAGIDQLVVSEHDILDGIALSIAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTS0</accession>
    <name>A0A132PTS0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tuf</name>
        <name evidence="10" type="ORF">AFM11_00085</name>
        <name evidence="11" type="ORF">AWC31_33190</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842055.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33190"/>
    <dbReference type="EnsemblBacteria" id="KWX25738">
        <property type="protein sequence ID" value="KWX25738"/>
        <property type="gene ID" value="AFM11_00085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11547">
        <property type="protein sequence ID" value="ORX11547"/>
        <property type="gene ID" value="AWC31_33190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.17"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX11547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="396" mass="43843" checksum="A130692BF81E83EA" modified="2016-06-08" version="1">MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKYPELNESRAFDQIDNAPEERQRGITINISHVEYQTEKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKSDAVDDEELIELVEMEVRELLAAQDFDEEAPVVRVSALKALEGDEKWVKSVEDLMDAVDESIPDPVRETDKPFLMPVEDVFTITGRGTVVTGRVERGIINVNEEVEIVGIRPDTTKTTVTGVEMFRKLLDQGQAGDNVGLLLRGIKREDVERGQVVVKPGTTTPHTEFEGQVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTDISVKLIQPVAMDEGLRFAIREGGRTVGAGRVTKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTW1</accession>
    <name>A0A132PTW1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844795.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25637">
        <property type="protein sequence ID" value="KWX25637"/>
        <property type="gene ID" value="AFM11_05270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2939"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="248" mass="26215" checksum="00D01F268E8ABF54" modified="2016-06-08" version="1">MGFIVPPDAYTRFMGRYAAPLAEVFVAFTGVGADDDVLDVGCGPGALTAHLLAVGAHVAAIDPSPPFIDGIRERFPDIDARLGTAEELPYDTASFDAALAQLVVHFMTDPVVGVRQMARVTRRGGTVAACVWDGPTGALGPFWDAVHLGDPEAKDEALLSGARAGHLTEIFEAAGLREVKEAPISVDVVHPTFEEWWEPYTYGVGPAGDYVQKLDGDGRARLESAARDHLGSGPFTVTATAWAARGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU72</accession>
    <name>A0A132PU72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_00790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842426.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33830"/>
    <dbReference type="EnsemblBacteria" id="KWX25863">
        <property type="protein sequence ID" value="KWX25863"/>
        <property type="gene ID" value="AFM11_00790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.162"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="302"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="489" mass="53706" checksum="C62B64CE1B7719DD" modified="2016-06-08" version="1">MSEVCVRDELRTLFLFEHLSDEQLDTLCEAGSIETFPAGPIVTEGDPATCFYVMLEGELIMSKRSGGVDLQTNRTSQRGVYFGAWSAYIPGEEHIYEASVRLTKPSRVFVLDANAFAAFMQSQFPMAVHLLEGHKVGGRRQSQIIGQREKLLALGTITAGLTHQLNNPAAATARAVADLREGVGKMRHKLAMLADGKFTPEALRVLVTIQDEVAEQVAKSKGLELTALETSDREDQIGDWLEDHGISSAWDYAPTFVEAGLDIDWLERIEASVDDVDASASLQGAIGWLKYTIDTELRMNEIAEASKRISALLAGAKQYSQMDRGSYQSADVHELLRSTLMMFGGKIGKDQPITLVKDMDKSLPELQCYPGDLNQVWTNIIDNAIQAMDGHGTLTIRTARENDEMIRVEICDDGPGIPEEIIGRIFTPFFTTKPFGEGTGLGLDLAWRIVVEKHNGDLRVHSEPGNTRFVVLLPLQAPAPLSAAVESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU82</accession>
    <name>A0A132PU82_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ORF">AFM11_00840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842450.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33880"/>
    <dbReference type="EnsemblBacteria" id="KWX25873">
        <property type="protein sequence ID" value="KWX25873"/>
        <property type="gene ID" value="AFM11_00840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.174"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="167"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="31470" checksum="A0E82A043A9F43B8" modified="2016-06-08" version="1">MPAIDSGGGHVRLRLDIAYDGTEFAGWAVQAGQRTVAGVIDEALTTVFRTPVVTRTAGRTDTGVHATGQVAHVDVPADALPHAYPRTARPGDSEFLPLVRRLARFLPADVRVREITRAPAGFDARFSALRRHYVYRLSTAPYGVEPQEARFVTPWSRPLDVEAMTAASQELLGLHDFAAFCRYRAGATTIRDLQRLEWVRDGHYVTAYVTADAFCWNMVRSLVGALLKVGEGRRETDWTATLLSATSRSSDFAAAPARGLTLVRVDYPPDDQMASRTAVTRDLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU99</accession>
    <name>A0A132PU99_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="12" type="ORF">AFM11_01115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842590.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34155"/>
    <dbReference type="EnsemblBacteria" id="KWX25918">
        <property type="protein sequence ID" value="KWX25918"/>
        <property type="gene ID" value="AFM11_01115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.229"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 12" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="11">
        <location>
            <begin position="294"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="11">
        <location>
            <begin position="466"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX25918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="621" mass="67284" checksum="26852E5D425444D0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUT0</accession>
    <name>A0A132PUT0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitermination regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843273.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35235"/>
    <dbReference type="EnsemblBacteria" id="KWX26119">
        <property type="protein sequence ID" value="KWX26119"/>
        <property type="gene ID" value="AFM11_02455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.503"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANTAR" evidence="1">
        <location>
            <begin position="134"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="228" mass="25574" checksum="95E5AF6C3613743F" modified="2016-06-08" version="1">MTNDPTQLDMQSSVEHALAGGEPQRVGSFRFYFADERWEWSPQVERMHGYEPGTAQPTTELVLSHKHPDDYGQVAATLDEIRRTSGAFSTRHRIIDTAGAVREVVVVGDQLFGDDGSVIGTHGFYVDVTPAITEAREQVVTEAVAEIAEARSGIEQAKGMLMLIYRINADSAFELLRWRSQETNTKLRLLAEQLAKDFLELDYNEILPNRVVFDRLLLTAHLRVGSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-12-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV65</accession>
    <name>A0A132PV65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_01020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26226">
        <property type="protein sequence ID" value="KWX26226"/>
        <property type="gene ID" value="AFM11_01020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="175" mass="19522" checksum="BF24FD2C411BA251" modified="2016-06-08" version="1">MDPQLADSIDRRIIDQLRIDGRRSFGEIGRYVGLSEAAVRSRYNRLRKLGIVQVVGMSDAPKLGEIEAHISIQVRGVTVDSVARQLAAHPEVKFVGAALGAFDLMLDVRCADNNHLSQFLHETVRRIRGIERLETATVLEVLEDSYLWAGFREATNRQAGAVEPCPTPPRKPNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PW56</accession>
    <name>A0A132PW56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_01580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26252">
        <property type="protein sequence ID" value="KWX26252"/>
        <property type="gene ID" value="AFM11_01580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.323"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="IclR-ED" evidence="3">
        <location>
            <begin position="45"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="230" mass="24434" checksum="27F926DC05157187" modified="2016-06-08" version="1">MGVSEIARRAHLPKSTAHRLLAVLVDWDMVTKRGTEYSPGARLNELAAIGSKPNNHELRRVALPHLLDLYEITHETVNLGILTGHDVLYIDKIHGHNGVNSPACVGGRLPAANTAIGKALLAFGDEGVVARISANLRPATSLSVASPAQLNRDLAAIRRYGVAYDRQESKPGLTCVAAPVRSWSGGVVAAISISGPVHRFRPADAAPAIRAAAAGIAKHVQQATWRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB95</accession>
    <name>A0A132PB95_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19574">
        <property type="protein sequence ID" value="KWX19574"/>
        <property type="gene ID" value="AFM11_35140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5756"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="96"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="282" mass="30622" checksum="CBE536CB880324A0" modified="2016-06-08" version="1">MPEFATVRYAMPGDDEGAWDLILVDDNDRRHEVNLAPGDADTVRALVSDGHGDSARVLAAMWTLWMDAASTNAESSAMASMPLRPYAHQTTAVYGAMLPQPLLRFLLADEPGTGKTIMAGLYIREMQRLGLVRRTLIVCPANLASKWIDDFERLLGGGLRQITAATVREDALNSNDLWVVSLELAAVNPAVQDALRPDKAGWDLVVFDEAHRLTPTAVGFHQVGRMLSVNTPRALLMTAMALDERQISYLQGTVNLVADADGVAELEQILVGLGISATVKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBA3</accession>
    <name>A0A132PBA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_34965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859583.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02055"/>
    <dbReference type="EnsemblBacteria" id="KWX19598">
        <property type="protein sequence ID" value="KWX19598"/>
        <property type="gene ID" value="AFM11_34965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5722"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="325" mass="35287" checksum="342CFEABE5714B2A" modified="2016-06-08" version="1">MTRFLARRLLNYLLLLALASFLTFTLTSFSFEPLDSLLSRNPRPPQSAIDAKAAELGLDKPIPVRYLDWASGAIRGDFGTTVTGQPVADELWRRIGVSLRLLVLGSVAGTVIGVVVGAWGAIRQYRLSDRAVTVVSLLVLSTPTFVIANLLILAALDVNSILGFRLFEYTGETSPDAIGGSWPRFVDRLQHLVLPTLTLALGAIASFSRYQRNAMLDVLSQDFIRTARAKGLTRRQALFKHGLRTALIPMATLFAYGVAGLVTGSVFVEKIFGWHGMGEWVVQGIATQDTNIIAAITVFTGTVVLLAGLLSDVIYAMLDPRVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBF6</accession>
    <name>A0A132PBF6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859496.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10975"/>
    <dbReference type="EnsemblBacteria" id="KWX19634">
        <property type="protein sequence ID" value="KWX19634"/>
        <property type="gene ID" value="AFM11_34835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5316"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="308" mass="31751" checksum="85D693C4F6761A00" modified="2016-06-08" version="1">MSRAVQFDQYGGIEVLRVRDVPRPEPASGEVLVQVRAAGINPGEAMIRRGALHDRFPATFPSGQGSDLAGVVAEVGQGVTGFEVGDEVIGFSERRSSHADHVAVPARQVTVKPVAVPWEVAGSLYVAGTTAYAAVRAVKLTDGDVVAIAGAAGGVGSIAVQLATRSGARVLGIAGPANDDWLTTHGATPVNYGDGLAERLRAASPSGRVDAFLDFFGGGYVAMAVDELGVVPERVDTVIDFAAIEQFGVQGAGNADASDIGVVAELADLAATGELEVPIAGVFALDDVQAAYRELEKRHTTGKLVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC02</accession>
    <name>A0A132PC02_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_33890</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858927.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07495"/>
    <dbReference type="EnsemblBacteria" id="KWX19846">
        <property type="protein sequence ID" value="KWX19846"/>
        <property type="gene ID" value="AFM11_33890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5116"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="219"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="345"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX19846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="544" mass="57571" checksum="4AC8DF963FF8662A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC91</accession>
    <name>A0A132PC91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858570.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16995"/>
    <dbReference type="EnsemblBacteria" id="KWX19955">
        <property type="protein sequence ID" value="KWX19955"/>
        <property type="gene ID" value="AFM11_33230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4978"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043746">
        <property type="entry name" value="DUF5691"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18944">
        <property type="entry name" value="DUF5691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="483" mass="52645" checksum="3DDD45B778C58665" modified="2016-06-08" version="1">MSDYQRIISAATVGLGAKPLPEAVFDAPVDTSAATVCEGDDPIGSVLRIAGLYAVARRAGQLPEHVKPNTDAAPPETRPLITETHAFLIERAVSVRPVLDGVIADIAAAGLRLPPRLIPELLRLYQSAGVTPELWAAIGSAGQWYAFEHYGRKHRALRHVMPVPGDGWPDEAEFTHGDTAKRLHWVAAARHIDPDRAREVVMAHWDAEDAESRALLLQAFATPEHERDEPFLESALDDRAGGVRSAAIAVLGNRNRSRYLERMKEHAAQVFSVKKSVLGVKITANELPEPDAAAIRDGLTTNQPDAVVERTPISFWDEFFGSVGPEKVVRAVSDDALLRALTVSALRGNDPRWAVPLLQRRLPADYANHYTPATAHPAITAELIRAVTNVAEGAPLAQIVAGLPRPFDPLVAEAMFGSLAGVGWGTQRQRREAAAHLAAGYPLDWHGRFADLVDRTTDEELHRFCATVFELLTLRIDIAKELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCD0</accession>
    <name>A0A132PCD0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32730</name>
        <name evidence="2" type="ORF">AWC31_32105</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858272.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32105"/>
    <dbReference type="EnsemblBacteria" id="KWX19980">
        <property type="protein sequence ID" value="KWX19980"/>
        <property type="gene ID" value="AFM11_32730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12600">
        <property type="protein sequence ID" value="ORX12600"/>
        <property type="gene ID" value="AWC31_32105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4875"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX12600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="162" mass="17495" checksum="552673C70D6ECCA4" modified="2016-06-08" version="1">MARSHRYEVQVTWTGNTGSGTSGYRDFARDHEIAGVDVAGKPSIPGTSDPAFRGTAERWNPEELLVASLSQCHMLWYLALCAQAGIVVTAYSDRPVGAMDESSDGSGNFTEVTLHPDVTIANPDRLADATDLHEQAHRMCFIANSVNFPVHTDPTMRTSSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCG0</accession>
    <name>A0A132PCG0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858794.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19917">
        <property type="protein sequence ID" value="KWX19917"/>
        <property type="gene ID" value="AFM11_33620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5057"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="342" mass="37721" checksum="CD1445B5B8BCBECC" modified="2016-06-08" version="1">MNEYDGKQFVGMDLHRRRSVIVRQSESGEQLAAVRIVNDPVALQAELEQAGVEPEVVLEATYGWYWAVDVLQAHGAHVHLAHPLGIKGFRYRRVNNDVRDAGDLADLLRMGRLPEAWIAPPQTRQLRELVRYRAKLVAIRSSLKAQVHAVLAKAGVLIAVSDLFGDTGRCNLAKVGLPAAYAQRVTSLLELIDTLDSHELRFSTLIADQLRTHRGYQAIQALAGVGPTLAAVFVAEIGEVQRFAGPAQLCSWAGLTPRHRESDTKVHRGHITKQGSKAVRWAAIEAVQHYCPTPKIAEDTDRIETRRGRNIAKVAAARKLLTLVYYGLRDGHIRALDKAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCK7</accession>
    <name>A0A132PCK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858097.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19570"/>
    <dbReference type="EnsemblBacteria" id="KWX20075">
        <property type="protein sequence ID" value="KWX20075"/>
        <property type="gene ID" value="AFM11_32445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4817"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="24"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="329" mass="35194" checksum="0DA6F35886F30F17" modified="2016-06-08" version="1">MTTATPKKRLTSDAMIASIAEGDKVVRAPFGHALLAAAKDNPLIVGLSADLAKYTDMHIFRDAMPDRFYQVGMAEQVLMGAAAGLAEEGFIPFASTYSVFATRRAYDFICLDIAERMLNVNIVAALPGLTTGYGPSHQATEDIAILRGMPNLTIVDPCDSVDIEQAVPELAASPGPTYLRLLRGAVPTVLDEYDYTFELGKAAKLRDGNEVLFISSGLMTERALQAAAQLEADNIGVAVVHAPTIKPLDEATILAEIAKDRLVFTLENHSVVGGLFESVASALVRNGVSRQVSPIALPDEFLVAGALPTLYDRYGVSTSRIVERVKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCQ0</accession>
    <name>A0A132PCQ0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Virginiamycin B lyase</fullName>
            <ecNumber evidence="1">4.2.99.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Streptogramin B lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">vgb</name>
        <name evidence="2" type="ORF">AFM11_32615</name>
        <name evidence="3" type="ORF">AWC31_19750</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Vgb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.-" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX17057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858170.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19750"/>
    <dbReference type="EnsemblBacteria" id="KWX20099">
        <property type="protein sequence ID" value="KWX20099"/>
        <property type="gene ID" value="AFM11_32615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17057">
        <property type="protein sequence ID" value="ORX17057"/>
        <property type="gene ID" value="AWC31_19750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4851"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017001">
        <property type="term" value="P:antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01282">
        <property type="entry name" value="VirginiamycinB_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011217">
        <property type="entry name" value="Streptogrm_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026412">
        <property type="entry name" value="Streptogrm_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="282" mass="28813" checksum="2FA4283296EF3CEC" modified="2016-06-08" version="1">MSNSLKVSIDGGPYALTAGPDGAMWVTLVHAGAIARVSPDGEVTTYPVGAGARPSIITAGPDGALWFTRAGDDRIGRITTAGELSAYELPEDSAPFGITAGTDGALWFTAMTSGAIGRITTDGEITSEIVVGGMPSMITTGPDGALWFTINQGNAIGRLDTDGSLSVRELPTAAAGPVGIAATHDDAVWFTEIQADKVGRIPMDDAIQELDLPGKPHAVVADPADGVWVSLWGADQLARISGDGEVVTIDLPSGSEPHGLAIGPDGAAWVALEAGFVLRMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCV3</accession>
    <name>A0A132PCV3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857843.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31885"/>
    <dbReference type="EnsemblBacteria" id="KWX20168">
        <property type="protein sequence ID" value="KWX20168"/>
        <property type="gene ID" value="AFM11_32010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4728"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="215"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="351" mass="35563" checksum="C5C5184DFE41FECD" modified="2016-06-08" version="1">MSASARWWGPAVDDDGRGLQTMLDEFIAAHAPVLDDDSAAVDALVRELAELGVWTLGTAESAGGGGADRTLTTVAFERLGRSWPALGWAAVQAHTAVDMLAADARFSSLVADLHAGTAAVAVADAESPHVRLEFSGAAISGTVDRVDAAADAPHLLVLLDATSAALIEPAALTPEALRRTGLSGALTRSLEVDANGAHVHRLSAVDVDAARVRLRLGVAAVAAGIAGVAADAAAAYSADRRQFGDTLTAIPTVRQSLMEQTARAVLILGAVLGAGEDPVQAAAVAMHALDSAIDVAAGALQSHGGYGYLVEYSAERHLRDAVSLRAAAAIGGQVTAAARTLVGATAKTLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCV9</accession>
    <name>A0A132PCV9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20134">
        <property type="protein sequence ID" value="KWX20134"/>
        <property type="gene ID" value="AFM11_31805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="63" mass="7287" checksum="68EAF5711D63CB85" modified="2016-06-08" version="1">MSRLTTKRDDADRSEKELFEESLREHGQLAHAESEELPPGATHEETTDETGERTVRRKRMSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDI8</accession>
    <name>A0A132PDI8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857649.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26340"/>
    <dbReference type="EnsemblBacteria" id="KWX20297">
        <property type="protein sequence ID" value="KWX20297"/>
        <property type="gene ID" value="AFM11_31720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4248"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="27677" checksum="06E0E339A5132EF5" modified="2016-06-08" version="1">MELGFEGAAAVVVGGGRGMGFATAQCLADDGAKVAIVGRSKDVLDAAAADLARRGSPDAVAIVADTGDQLQVERAFAEIGERWDGELNALINTVGPGAAGNFEQLTDEQWQEAFDAGLMGMVRCVRAALPLLRKAEWARIVNFSAHSTQRQSTRLPAYTAAKAAVNSVSKNLSLLLAKDEIMVNVLSPGSISSEALLGWADSVGVDGTDPYKLMAAIDEHFGHPAHLPRAGLPNEIGPVAAFLASRRNSYMTGANVNVDGGSDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDX6</accession>
    <name>A0A132PDX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857059.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00620"/>
    <dbReference type="EnsemblBacteria" id="KWX20539">
        <property type="protein sequence ID" value="KWX20539"/>
        <property type="gene ID" value="AFM11_30630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4027"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452986" evidence="1">
        <location>
            <begin position="32"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="283" mass="29687" checksum="50F6458250917B00" modified="2016-06-08" version="1">MRSNIVALVGAAALVISACSTTTTPQPGPQAPDGMAHIHGLGINPADGALYAGTHYGVYRIAADRKPARVSDVVQDFMGFTVVGPDHFLGSGHPAEHAADQPPNLGLIESTDGGRSWTPVSLSGNADFHALEYRDGLVIGLDSTTRTVMVSTDQHTWQPRATLPAIDIAVSPDNPNEVLATTAQGVMRSTDQAATFTPAGTGPALAFVAWPDDGPLIGVDPAGAVYVSPDAARTWQQRRELHQQPQALLAAGDGVVYLATDTAIHRSTDNGTTFETYYALEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE26</accession>
    <name>A0A132PE26_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_29770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856708.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25110"/>
    <dbReference type="EnsemblBacteria" id="KWX20589">
        <property type="protein sequence ID" value="KWX20589"/>
        <property type="gene ID" value="AFM11_29770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3846"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="395" mass="40377" checksum="1AF6AE8D81766FB3" modified="2016-06-08" version="1">MPVAIWIIGLAIFAQGTSELMLAGLLPEMSADLGVTIPQAGLLVSVFALGMLVGAPVLAIATLRWSPRRAMVAFLAIFVVAHIVSALSSSYAVLMTARFVAAFVYAGFWAVGAGTAMTLVGAERRGRAMSIVAGGLTVATVIGLPAGTWIGQHLGWRGAFWAVAALSCVAAGAVLAAVPDTRPDTEPRIGDELRGLAVPRLWLSYAMTAVSTAALLGTFTYLAAMLITTSGLQPQWVPAVLLGYGLGALVGMAVGGQVADRWPRATLAAGFTTLLVVLVALALTTRHVTAVSALACLLGFAGFGTNPALNSRVFALAPSAPTLTAAGNVASFNVGISVGPWVAGIALTAGLGYPAVPWIGAALAVLALVLLAIDVRMAGRVQEGIWRGSRVLRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEJ6</accession>
    <name>A0A132PEJ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_28340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ro 60 kDa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856065.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32620"/>
    <dbReference type="EnsemblBacteria" id="KWX20759">
        <property type="protein sequence ID" value="KWX20759"/>
        <property type="gene ID" value="AFM11_28340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3542"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040322">
        <property type="entry name" value="TROVE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008858">
        <property type="entry name" value="TROVE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037214">
        <property type="entry name" value="TROVE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202">
        <property type="entry name" value="PTHR14202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05731">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140864">
        <property type="entry name" value="SSF140864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50988">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="TROVE" evidence="4">
        <location>
            <begin position="23"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="564" mass="61116" checksum="2BD86558AA462C2E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEL1</accession>
    <name>A0A132PEL1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_28460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32700"/>
    <dbReference type="EnsemblBacteria" id="KWX20778">
        <property type="protein sequence ID" value="KWX20778"/>
        <property type="gene ID" value="AFM11_28460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3570"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="29"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="64"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="33081" checksum="4EC2C0D1ED34F700" modified="2016-06-08" version="1">MRPYFEDVQAHYDLSDEFFGLFQDPSRTYSCAFYERDDMTLEEAQMAKIDLALDKLGLQPGMTLLDVGCGWGALMKRAMEKYDVNVIGLTLSNNQYAFCQSLLEQTGSDRQHLVHLKGWEQFDDPVDRIVSIEAFEAFGKSRYAAFFDMAHRVMPADGRMVIETIFTHPINYWREHGIPVTLTDMKFMRFIGKEIFPGGQLPSDVDMVEFSDKAGFSTDETQLMNEHYVRTLDTWAENLTARRDEAIATTSQEVFDRYMHYLTGCADFFRRGISEVAQFTFNKRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEQ2</accession>
    <name>A0A132PEQ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856257.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32990"/>
    <dbReference type="EnsemblBacteria" id="KWX20819">
        <property type="protein sequence ID" value="KWX20819"/>
        <property type="gene ID" value="AFM11_28760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3630"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="160"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="231" mass="24263" checksum="D69FEA7DF8B9D503" modified="2016-06-08" version="1">MHYFALLISQERELTPDEATEGMAAFQAFHAKAGSAIRAGDALAPTAHAVRITGGPDAPVVTDGPFAEAAEVACGYYVLEADNLDEALALARDIPVATFGAVEVWPMVGWNPPSQQLGSDWLALLLEPEDNVCAPSTEEWESGVCAHTEFGNAAGEHILSGAPLHPPSTATTVRVRNNDVVLTDGPYVEGAEVANGFYVLRAADRDEAVKLASMIPASAVELRRLAGVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PES1</accession>
    <name>A0A132PES1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_28865</name>
        <name evidence="7" type="ORF">AWC31_33095</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856317.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33095"/>
    <dbReference type="EnsemblBacteria" id="KWX20839">
        <property type="protein sequence ID" value="KWX20839"/>
        <property type="gene ID" value="AFM11_28865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11532">
        <property type="protein sequence ID" value="ORX11532"/>
        <property type="gene ID" value="AWC31_33095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3651"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX11532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="371" mass="40199" checksum="E8CB6B4EB7684843" modified="2016-06-08" version="1">MGVQIDVNGLSKSFGSSKIWEDVTLSVPAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSIIIDGTDILECSAKELYEIRTLFGVLFQDGALFGSMNIYDNTAFPLREHTKKSESEIREIVMEKLALVGMPNDGHKFPGEISGGMRKRAGLARALVLDPQIILCDEPDSGLDPVRTAYLSQLLIDINAQIDATVLIVTHNINIARTVPDNIGMLFRKKLVMFGPREVLLTSEEPVVKQFLNGRRIGPIGMSEEKDEATAAAEQALLDAGQHDGGVEEIEGVPPQLTATPGMPERKGVARRRARVREILHTLPPQAQAAILEELNAHDAQQGGQVQTQTAPVDNYDEPTARHSRPIEDDAPTGAIEVPKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEU0</accession>
    <name>A0A132PEU0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856347.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20850">
        <property type="protein sequence ID" value="KWX20850"/>
        <property type="gene ID" value="AFM11_28485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3575"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045732">
        <property type="entry name" value="DUF6086"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19564">
        <property type="entry name" value="DUF6086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="117" mass="13186" checksum="076C687DCF5EA100" modified="2016-06-08" version="1">MSFIFDVGDDTVWSPALRVGDLYVRFITQIGEHLGLPTGLSSMASDYYYIDPDIFEALVKKMFEENFRSTHQVGRAMLESVLAPSAVILDRIIRPLSAATPDEREFLEKARALSMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF58</accession>
    <name>A0A132PF58_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28250</name>
        <name evidence="4" type="ORF">AWC31_10800</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855917.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20961">
        <property type="protein sequence ID" value="KWX20961"/>
        <property type="gene ID" value="AFM11_28250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08970">
        <property type="protein sequence ID" value="ORX08970"/>
        <property type="gene ID" value="AWC31_10800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3524"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453224" evidence="2">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX08970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="150" mass="16917" checksum="2FFBB7E9B0780144" modified="2016-06-08" version="1">MNTRKTLRTAVAATLTVGALGFGVTAFGSPVASASPIAPAPLKPGHGNDDCFPFCDRGPGRDFDRGHWKDDHWDDKGPWWANNRHDWWDDRKGPPPWGWGPPPPVHWNGPLPPTINYWGYNLNPVWDNGFRQWGVWFFGVWVPIFGVGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFD3</accession>
    <name>A0A132PFD3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_27910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855760.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20917">
        <property type="protein sequence ID" value="KWX20917"/>
        <property type="gene ID" value="AFM11_27910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3456"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="187" mass="20230" checksum="CD480279B01003CB" modified="2016-06-08" version="1">MSRWEPDAQGRLAQAALELYSERGFDQTTVAEIAQRAGLTERTFFRYFADKREVLFWGEGVLHNVFVTAVAGADEALSPIDAVAAGLDAAGEMFAGRYDHARRRQAVIAANTALQERELIKLASLAAGVGDALRNRGVSDIAADLAAEAGIAVFKVAFERWISGTREQDLSGVIRAALEEMRTLTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFP8</accession>
    <name>A0A132PFP8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854786.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21155">
        <property type="protein sequence ID" value="KWX21155"/>
        <property type="gene ID" value="AFM11_26190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3104"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041669">
        <property type="entry name" value="TetR_C_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17918">
        <property type="entry name" value="TetR_C_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="22407" checksum="750D6E7A30587FF6" modified="2016-06-08" version="1">MSDAPRKAPRQDRSRETVDVVLEAAAQVFEREGLSATTNRIAERAGVSIGSVYQYFPNKHALLYALAERHVRDTVERLDKVFGRLRTELPPFDDTMRRILGEVVALHSDRPGLHGLLHRVAPRRAKELAALQEFEDHLAREIAFHLERCDRAGDDDPLVTAQVLVHAIDAHLHRVLTRRGMDVDQLVDLVERLLAHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFW9</accession>
    <name>A0A132PFW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854946.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22855"/>
    <dbReference type="EnsemblBacteria" id="KWX21203">
        <property type="protein sequence ID" value="KWX21203"/>
        <property type="gene ID" value="AFM11_26480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3166"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="448" mass="48008" checksum="4210C7E0ABE7459C" modified="2016-06-08" version="1">MTEYAVTDPATAEVVATYPTATDAEIEAAIEAAAKTGRAWPRTSTVAERAAMLGKVADLHEQRREQLADVIVREMGKPRDQSLSEVDFCADIYRYYAQNAEKFLADEEIKLLDGEGTAVVKRGPIGVLLGIMPWNYPYYQVARFAGPNLVIGNTILLKHAPQCPESAELLQLLFLEAGFPQGAYIDIRATNDQVAAIIADPRVAAVSLTGSERAGAAVAEIAGRNLKKCVLELGGSDPFIVLSTDDLDATVESAVEARMENTGQACNAAKRFIVAENLYDDFLTKFTDKLLAAADGIAPLSSEQAAERLEQQVKAAVGQGAQLTSSGERHGAFYPPAVLTGVTEDNDAYRQELFGPVAVVYKAGSEDEAVAIANDTPFGLGSYVFTTDKDQAQRVAEKIDAGMVFVNAVGAEGAELPFGGVKRSGFGRELGRFGIEEFVNKKLIRTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG09</accession>
    <name>A0A132PG09_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_26705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855061.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22630"/>
    <dbReference type="EnsemblBacteria" id="KWX21243">
        <property type="protein sequence ID" value="KWX21243"/>
        <property type="gene ID" value="AFM11_26705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3212"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013207">
        <property type="entry name" value="LGFP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08310">
        <property type="entry name" value="LGFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGRP" evidence="3">
        <location>
            <begin position="194"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="535" mass="56922" checksum="B096E0374DCF33CA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGC1</accession>
    <name>A0A132PGC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkane 1-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_26070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854652.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35825"/>
    <dbReference type="EnsemblBacteria" id="KWX21381">
        <property type="protein sequence ID" value="KWX21381"/>
        <property type="gene ID" value="AFM11_26070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3079"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03512">
        <property type="entry name" value="Alkane-hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033885">
        <property type="entry name" value="AlkB/XylM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38674">
        <property type="entry name" value="PTHR38674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="134"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="411" mass="46767" checksum="E2DBC44A3069B5ED" modified="2016-06-08" version="1">MVAELSGNPGASEVRQWRDKKRHLWLMGLIAPTAMFVVLPLVWAFNQLGWHIAAQIPLWIGPILLYVLLPLLDLRFGPDGQNPPDEVMEQLENDKYYRYCTYVYIPFQYASVVLGAYLFTASDLGWLGFEGGLGWPAKIGVALSVGVLGGVGINTAHEMGHKRDSLERWLSKITLAQTWYGHFYIEHNRGHHVRVATPEDPASARFGETFWEFLPRSVFGSLKSSWELEAQRLRRQNKSPWHPSNDVLNAWAMSVVFWGVLIAIFGVGVVPFMLIQAVYGFSLLESVNYLEHYGLLRQKTPSGRYERCAPVHSWNSDHIVTNLFLYHLQRHSDHHANPTRRYQTLRSIDGAPNLPSGYASLIGLTYLPPLWRKVMDHRVLEHYDGDITRVNIQPRLRDKVLARYGAAGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGF8</accession>
    <name>A0A132PGF8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853964.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26965"/>
    <dbReference type="EnsemblBacteria" id="KWX21425">
        <property type="protein sequence ID" value="KWX21425"/>
        <property type="gene ID" value="AFM11_24710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2303"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="51"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="261"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="36835" checksum="7CC075F152684BD2" modified="2016-06-08" version="1">MTTAARVQPNQHEMANAHRIVNAIAQVFSSKVVGQENLRESLLIGVLTGGHILLESVPGLAKTTAARVVADSISGGFQRIQCTPDLLPSDIIGTQIYDSSSGQFVTQLGPVHTNIVLLDEINRSSAKTQSAMLEAMEERQTTIAGKLYPIPEPFVVIATQNPVDQEGTYPLSEAQTDRFMLKEVLRYPTPQEEAEVIFRIDAGVYDRGEKPRPVVGLDDMRRLQNVVRSVHLDPVLVHYITQLINVTRNPQQFLPPQMAKLVQYGASPRASIAFSRAARALAVLQGRNHVLPDDIQKLAHRVLRHRLILGFEAARLNVTSETIIDAVLQSVRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGH9</accession>
    <name>A0A132PGH9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854064.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27155"/>
    <dbReference type="EnsemblBacteria" id="KWX21458">
        <property type="protein sequence ID" value="KWX21458"/>
        <property type="gene ID" value="AFM11_24900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2341"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="141" mass="16079" checksum="19BDE53C53B4472F" modified="2016-06-08" version="1">MTAQEDDHIRPSGVDGATVEAVGVVSEALEHVERARGHLYSFHQVMGHADLLLGEACDKLREAGHGEIADRLTEDLVGRNVINGRWTFQVVEEFDDGYWSRFRAHEKRVRDDLMDGKRHVYEAEMKERRRSQGRDGHEATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGX3</accession>
    <name>A0A132PGX3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_23830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853438.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24315"/>
    <dbReference type="EnsemblBacteria" id="KWX21571">
        <property type="protein sequence ID" value="KWX21571"/>
        <property type="gene ID" value="AFM11_23830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2124"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453026" evidence="2">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="37"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="331" mass="33911" checksum="AEB8844AB2A93554" modified="2016-06-08" version="1">MLGKRMGTLTVGTVLMAGSLVLGLTACGGSDSGSVKVGLITKTDSNPYFVKLRESAQAQADKDGAELIAVAGAFDGDNEGQVSAIENMIGQGVKGILITPNSSTGVLDAIKKARDAGIVVIALDTATDPEDAVDATFATDNKAAGVSQGKWVKAALGNTAPQIVMLDGTPGGTVDTFRHDGFLEGFGITNDSPEIVGRENTNGDQTKAQTAMENLLQRAPGVNALYTINEPAAAGAYQAIQSANRTGQITIGSIDGSCTGVADVKSGKIGATVMQFPAKMAEQGVQAVVKFAKDGTKPSGFNDTGSQLITDRPVPGLESKDTAWGEQNCWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH04</accession>
    <name>A0A132PH04_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23995</name>
        <name evidence="2" type="ORF">AWC31_24160</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853535.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24160"/>
    <dbReference type="EnsemblBacteria" id="KWX21601">
        <property type="protein sequence ID" value="KWX21601"/>
        <property type="gene ID" value="AFM11_23995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15644">
        <property type="protein sequence ID" value="ORX15644"/>
        <property type="gene ID" value="AWC31_24160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2158"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX15644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="63" mass="7165" checksum="D63F9F996802B1B0" modified="2016-06-08" version="1">MAKYRVLNPQGEVVDTKDIESAGDAHAWFVDQKAKPELGWRMEVLSADGDWAFFDSSEGDRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH23</accession>
    <name>A0A132PH23_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853601.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24000"/>
    <dbReference type="EnsemblBacteria" id="KWX21621">
        <property type="protein sequence ID" value="KWX21621"/>
        <property type="gene ID" value="AFM11_24130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2185"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="97" mass="10661" checksum="2CB3DDB32F1C1BF2" modified="2016-06-08" version="1">MPADRLPQEPGPDAGIDEIQSDIEQTRNELGETIGALTDKLDVKSRAQDKAAETKEAVVERAHVATEAVKSQPAVPVATVVAVLAAIGFMWWWRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH66</accession>
    <name>A0A132PH66_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23730"/>
    <dbReference type="EnsemblBacteria" id="KWX21661">
        <property type="protein sequence ID" value="KWX21661"/>
        <property type="gene ID" value="AFM11_24395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2239"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="219" mass="23343" checksum="2719FACD8D618D2E" modified="2016-06-08" version="1">MDVNLNGEPSPVYFPQEDSMRIDAARNRSTVLDAAEQVFAEQGLDASLNEIARRAGIGNATLYRHFPTRGALVDELFERQMEQYVATAERAAAADDSGTAFRECVTATCELQAANRALADLLVSTRPVSPAVDALRLRQHAAIVDVVERAVAAGEVREDLRPADVAVLLIANAGLIRRTVDDAPGASARLVALWLDGTAGSGTAPPAPAEAEISRALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHA4</accession>
    <name>A0A132PHA4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853487.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24240"/>
    <dbReference type="EnsemblBacteria" id="KWX21587">
        <property type="protein sequence ID" value="KWX21587"/>
        <property type="gene ID" value="AFM11_23915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2141"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="SSF56574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="405" mass="43106" checksum="32A108926ADF9E05" modified="2016-06-08" version="1">MPGAETSEIVSAYAAEFNRRLLDGHAVTSPLGAWLLLALVGPAAGGASRRDLEAVLGTTVDDAAERARSLLSQPHPAVSAIAAVWDRELGPAFDAWAETLPDVVERGPVPDQARANAWARARTNGLIDEFPLSIDSLVRLVLASALATDIRWGTPLGTVEELGGEFGTAVNRALSLQHGLQLVAETDAAGLVAVAAPYSSSALEVLSVIAAPDVSPRDVDTAAHQVAAMLRGDERGARRLPAEELTDGHAWTVTERREQRSGGPQVQAEFRSFLPAWSATSNHDLADAPGVPMVFDTLTGFARREDLPVSFTAKQTAIASYSRTGFKAAAVTAMGLRAAGMPSFHEVLVRRIELRFNRPYAVLACAARDDGPTEWRGVPVFSAWVTEPQDIEPDDPGPPRPVPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHB0</accession>
    <name>A0A132PHB0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24075</name>
        <name evidence="4" type="ORF">AWC31_24045</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853574.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24045"/>
    <dbReference type="EnsemblBacteria" id="KWX21716">
        <property type="protein sequence ID" value="KWX21716"/>
        <property type="gene ID" value="AFM11_24075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15624">
        <property type="protein sequence ID" value="ORX15624"/>
        <property type="gene ID" value="AWC31_24045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2174"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX15624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="266" mass="28646" checksum="3508D8F4FFDA36EC" modified="2016-06-08" version="1">MVDIAVAQFAPGTDKAENLRSIAKFTAEAAASNARVLAFPEYSMFTVPVMDNRFVESAEGLDGPFVTGLREIAVQHGMHLVAGINEAIAGENRIFNTLVAVSPAGEIEARYRKLHLYDAFGYKESDMVKPGSVEKPETFVVDGITFGMQTCYDLRFPEVTRRIVDAGGDVLLLPAEWVPGPLKEDHWTTLVRARAIENTIYVAAADQSAPAGSGASAIIDPMGLVLASLGERVGTVTAKVDPERITEVRAKNPALSLRRFTIAPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHQ9</accession>
    <name>A0A132PHQ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_23695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853325.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28415"/>
    <dbReference type="EnsemblBacteria" id="KWX21851">
        <property type="protein sequence ID" value="KWX21851"/>
        <property type="gene ID" value="AFM11_23695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2095"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="237" mass="25721" checksum="95F134C31159B14A" modified="2016-06-08" version="1">MIDTALPEVTTNLALMPDFMDPINLIGYFGTWALVGILVVVFVESGVLFPILPGDSLLFVAGMLAAGTAAQGEAVQANFELWHLLVGIPIAAVLGGQVGYFIGRTIGTSMFKPNARVLKQKYLDEAHVFFEQRGPFAIVIARFVPIVRTLAPITAGAAKMRYPVFTFFNVLGAVIWGVGLTLLGYWLGSFEIIQKLLEPIFILIVVASVAPMFIEWYKRRRAAKRAAATEATAAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHZ9</accession>
    <name>A0A132PHZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Benzoylsuccinyl-CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852800.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08530"/>
    <dbReference type="EnsemblBacteria" id="KWX21965">
        <property type="protein sequence ID" value="KWX21965"/>
        <property type="gene ID" value="AFM11_22675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1885"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="155" mass="16635" checksum="C75EA71490F79AF4" modified="2016-06-08" version="1">MPAASTQPAIEGWFAADDSGATHLIGGKCAQCATYVFPPRENNCPNPACDSDVLNLVPLSRRGKVWSYTENRYPPPAPYPAPDPFEPFAIAAVQLADEGLIVLGKVVEGTLAADLKVGMDMELTTMPLYTDADGVERTTYAWMVADARSKEGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIA1</accession>
    <name>A0A132PIA1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852939.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22033">
        <property type="protein sequence ID" value="KWX22033"/>
        <property type="gene ID" value="AFM11_23050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1961"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="409" mass="43829" checksum="495AD0786EAE607B" modified="2016-06-08" version="1">MAQRIKVSPDLIGGDVDEGYGRVADVFRANLGSGQEVGAAVAVYRDGRKVVDLWGGFRNGNTAAPWQQDTIVNVFSTTKGVAALAVAVAASRDLISYDAKVADYWPEFAQAGKHAITVRQLLAHQAGLSAIKPSLTLDELADPERLAKKLAAQAPAWTPGTRHGYHSTTLGFYESELIRRTDPAKRTLGQFFAEEIAKPLSLEFYIGLPETVDRDRVAYLHAWSMAELLLHLNTWPPRFSIAVLNPFSLEARSVSYAKGVTGPASFNREELRVVEIPAANGTGDARSVAKLYGNAAMGGSEMGLTPTTLDALQQSAPPPTNGPHDKVLHIDTSFSLGLCKPASAWIFGSSGNAFGTPGAGGSFGFADPDTGIGYGYVMNRLGFHLDSDPRELALRNALFQDILGCRPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIS4</accession>
    <name>A0A132PIS4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852499.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04785"/>
    <dbReference type="EnsemblBacteria" id="KWX22164">
        <property type="protein sequence ID" value="KWX22164"/>
        <property type="gene ID" value="AFM11_21980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1744"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="52"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="202" mass="20882" checksum="0D3E71361F7161F8" modified="2016-06-08" version="1">MNAALAINHHADHPGFSGATGVLFGVMFMLVGRAKAKLAARVADVSPADHVVDVGCGPGTAARVAARNGARVTGVDPSAAMLRVAGFVTRKGDITWCEGAAEDLPVEGSTATVVWALATVHHWQDVDKAIGEAHRVLSPGGRLIAIERQSPVGATGLASHGWTRQQAESFASLCRDTGFDNVCVGTHGSGRGAVWIVSGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJG8</accession>
    <name>A0A132PJG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate/guanylate cyclase with integral membrane sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_21190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22337">
        <property type="protein sequence ID" value="KWX22337"/>
        <property type="gene ID" value="AFM11_21190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1584"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="256"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="340"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="536" mass="56414" checksum="D7F19A4AB8B13CCD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJQ1</accession>
    <name>A0A132PJQ1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_20600</name>
        <name evidence="11" type="ORF">AWC31_06015</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852010.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06015"/>
    <dbReference type="EnsemblBacteria" id="KWX22242">
        <property type="protein sequence ID" value="KWX22242"/>
        <property type="gene ID" value="AFM11_20600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09774">
        <property type="protein sequence ID" value="ORX09774"/>
        <property type="gene ID" value="AWC31_06015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1457"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="99"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="170"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="346"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="420"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX09774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="562" mass="62783" checksum="A9CD947BF6D3E7FB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJU4</accession>
    <name>A0A132PJU4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15170"/>
    <dbReference type="EnsemblBacteria" id="KWX22605">
        <property type="protein sequence ID" value="KWX22605"/>
        <property type="gene ID" value="AFM11_19070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1147"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="211" mass="22729" checksum="DE70C0450412BCC1" modified="2016-06-08" version="1">MTSARRPGQARTRLARAAVIRAARALFLERGYGATTIEAISTESDVPPATVYRLFSSKRGILKAILDVSIAGDDEPVSLPERPKIQALVADPDPKNQLAGLVAVASDVNSRTAPVYRILVGAASSDADAAALLDDLNSQRRQGQGQIVRALARSGALRAGLAERDAIDIVYTLMSPEVYRLMVVDREWPPRSYERWVTQALADSLLPPPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKB9</accession>
    <name>A0A132PKB9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17740</name>
        <name evidence="3" type="ORF">AWC31_11860</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851138.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11860"/>
    <dbReference type="EnsemblBacteria" id="KWX22790">
        <property type="protein sequence ID" value="KWX22790"/>
        <property type="gene ID" value="AFM11_17740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18690">
        <property type="protein sequence ID" value="ORX18690"/>
        <property type="gene ID" value="AWC31_11860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.903"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="340" mass="36890" checksum="2554AB3CAA3709BB" modified="2016-06-08" version="1">MTERKPNLRTVREVTPTLEFRTIHGYRRAFRVAGSGPAILLIHGIGDNSTTWHTVQSTLAQRFTVIAPDLLGHGRSDKPRADYSVAAYANGMRDLLSVLDIDRVTVVGHSLGGGVAMQFAYQFPQLVDRLILVGAGGVTKDVNVALRIASLPMGSEALALLRLPLMLPALQVFGRAVGTVFGSTGVGRDIPDMLRILADLPEPTASSAFARTLRAVVDWRGQVVTMLDRCYLTESVPVQLIWGESDSVIPVSHARMAHAAMPGSQLEIFKGSGHFPFHDDPDRFVEVVERFIDSTEPAVYDQEMLRSLLRTGLSESTISGSLDTQVAVLEAMGGDERSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKD1</accession>
    <name>A0A132PKD1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/galactose cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_20230</name>
        <name evidence="9" type="ORF">AWC31_11485</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000036">
        <property type="protein sequence ID" value="ORX08745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851925.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11485"/>
    <dbReference type="EnsemblBacteria" id="KWX22482">
        <property type="protein sequence ID" value="KWX22482"/>
        <property type="gene ID" value="AFM11_20230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08745">
        <property type="protein sequence ID" value="ORX08745"/>
        <property type="gene ID" value="AWC31_11485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1381"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX08745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="573" mass="61376" checksum="5CEE9B786931A1AF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKJ9</accession>
    <name>A0A132PKJ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_18245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851307.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12315"/>
    <dbReference type="EnsemblBacteria" id="KWX22866">
        <property type="protein sequence ID" value="KWX22866"/>
        <property type="gene ID" value="AFM11_18245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1006"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043641">
        <property type="entry name" value="PPE-PPW_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18878">
        <property type="entry name" value="PPE-PPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="PPE" evidence="4">
        <location>
            <begin position="8"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PPE-PPW" evidence="5">
        <location>
            <begin position="452"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="508" mass="51762" checksum="FDEDBE1606B777E9" modified="2016-06-08" version="1">MTAPVWMALPPEVHSTLLSSGPGPGPLLAAAGAWNSLSAEYASAAAELSTVLGTVQAGAWQGPSAERYAAAHVPYLAWLTQTSAVSAGVAAQIETAAASYSAALAAMPTMAELTANRATLGVLVATNFFGINTIPIAVNEADYIRMWIQAATTMTVYQATSQVAVTSAPQTTVAPFVLTPGISETATASATLMQTAAHARATESGLALTFEDPIEKWLAENSEHFHGMYVQLKELILQPWRIPQILAEIIADPSLLFTTYINVFFLGAYAATFAVLGTPLYAAVIGAVSPAMLGLLGLIGLAQNYNIPIDAPAPEAVNQPAEPAPVAALPGPSSPSVPASTPAPPSPASPTVATAPAPTPTVTGVETSAYAVGGDGPGFGFGPSMRSSAVDVAHSSNSAAASAAAAASAVARDRSKSRKRRGADVKERGYRYEYLRMDDDGSAPPPERAAASASSRGAGNLGFTGTATKSTATNPAGLTTLAEDSYGSGTAVPMMPGTWSTDAPSDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKV9</accession>
    <name>A0A132PKV9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850648.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01160"/>
    <dbReference type="EnsemblBacteria" id="KWX22979">
        <property type="protein sequence ID" value="KWX22979"/>
        <property type="gene ID" value="AFM11_16510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.651"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="437" mass="47346" checksum="91CD307619B745A1" modified="2016-06-08" version="1">MTAPLFPSPAEVEASTPPDRDRAIDVIRIVSLVGVVFGHTVMATSTIRDDVFIWSNLLTASTVFQALTWLFQIMPLFFFAGVAACVQSWRPGTSWGGWLLRRCTRLYRPVFYYLAFWTAALAILRFLLPEHVYEPVAGISIQLLWFLGAYVLVLAAVPLLARITTTAQLVGAVVGTYAFIALIDAVRITTDGAGYASLGYLNTVVWLIPGMFGVAYRRNLLPAPAALKVGLGMLGVNLALLYFGPYELSLVGIETQQLKNMTPPSLLLAGHAIMMCAFAIAAAPAISRWAQRPRVWWLAAIGNSGAMTLYLWHMPLLLAMHLVLDYLGLDRYDPTVPGFVTLSIVQLVLMAGLVGLAFVALRPLENSPLPLWDGGSVSMPGMRSAAVGLLLCVAGAATLTSVAWGLKDQGVYWVAIMVAALIAARWTASMRRVTATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL42</accession>
    <name>A0A132PL42_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monoacyl phosphatidylinositol tetramannoside-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_16715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850727.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01285"/>
    <dbReference type="EnsemblBacteria" id="KWX23013">
        <property type="protein sequence ID" value="KWX23013"/>
        <property type="gene ID" value="AFM11_16715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.695"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453382" evidence="2">
        <location>
            <begin position="27"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="95"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="612" mass="63642" checksum="F50B22B2BD0C292A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL58</accession>
    <name>A0A132PL58_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17140</name>
        <name evidence="3" type="ORF">AWC31_01705</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850877.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01705"/>
    <dbReference type="EnsemblBacteria" id="KWX23085">
        <property type="protein sequence ID" value="KWX23085"/>
        <property type="gene ID" value="AFM11_17140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13269">
        <property type="protein sequence ID" value="ORX13269"/>
        <property type="gene ID" value="AWC31_01705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.781"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="88" mass="8994" checksum="CE100D35C12C97F1" modified="2016-06-08" version="1">MVRTPLTPEQIAAGRRLGKTLRDARGSRTLDDVAAQAGISPETLRKIETGRLPSPAFGTVVGLSAALGIDLQALADAWSDAGAPAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL78</accession>
    <name>A0A132PL78_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850907.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01785"/>
    <dbReference type="EnsemblBacteria" id="KWX23101">
        <property type="protein sequence ID" value="KWX23101"/>
        <property type="gene ID" value="AFM11_17220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.797"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="455" mass="47204" checksum="A08E6575ED77CFFA" modified="2016-06-08" version="1">MSNDALTGLIAQLPDGVVVTDPDILASYRQDRAADPDAGTPLAVVRPHRTQEVQTVLRWASKHQIAVVPRGAGTGLSGGATALDGGIVLSTEKMRDITVDTVTRTAVVQPGLLNAEVKKAVAEHGLWYPPDPSSYEICSIGGNVATNAGGLCCVKYGVTTDYVLGLQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGIVTEVTLRLLPPQHSPCTVVATFDSVEAAAGAVVKITGRIRPSMLEFMDAVAINAVEDKLRMGLDRTAAAMMVAASDDRGAAGADDAAFMAEVFTECGATEVFSTSDPDEGEAFVAARRFAIPAVEAKGSLLLEDVGVPLPALADLVSGVAKIAEQRDLLISVIAHAGDGNTHPLIVFDPADADMADRAQLAFGEIMDLAVGLGGTITGEHGVGRLKRPWLAGQIGPDAMELNQRIKRALDPDNILNPGAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLK8</accession>
    <name>A0A132PLK8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable 5-dehydro-4-deoxyglucarate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5-keto-4-deoxy-glucarate dehydratase</fullName>
            <shortName evidence="4">KDGDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_15520</name>
        <name evidence="7" type="ORF">AWC31_16265</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:24608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:42819"/>
            <dbReference type="ChEBI" id="CHEBI:58136"/>
            <dbReference type="EC" id="4.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Carbohydrate acid metabolism; D-glucarate degradation; 2,5-dioxopentanoate from D-glucarate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 5">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.41" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850260.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16265"/>
    <dbReference type="EnsemblBacteria" id="KWX23230">
        <property type="protein sequence ID" value="KWX23230"/>
        <property type="gene ID" value="AFM11_15520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17961">
        <property type="protein sequence ID" value="ORX17961"/>
        <property type="gene ID" value="AWC31_16265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7220"/>
    <dbReference type="UniPathway" id="UPA00564">
        <property type="reaction ID" value="UER00628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047448">
        <property type="term" value="F:5-dehydro-4-deoxyglucarate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042838">
        <property type="term" value="P:D-glucarate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00694">
        <property type="entry name" value="KDGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017655">
        <property type="entry name" value="Dehydro-deoxyglucarate_dehyd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX17961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="307" mass="31992" checksum="6A1B9F04A901A4BE" modified="2016-06-08" version="1">MLDGVLFFPVTPLTAAGEVDVDRLAQHVAKGVDAGPGGVFIGCGTGEFHALEPSEMSTVVRTAVEAVAGRVPVYAGAGGSIASAKTFARVAAEAGADGLLLLPPYLVEMPQAGLVGYTREVSSVTDLPLVVYNRNNARFNEASAVEVAQLPNVVGFKDGTGDFDQVARIVRAVTDALAPSGKPFQFFNGLPTAEVSQQAYRAIGVTLYSSATFAFAPDLALAFYQALETGNEALTAALLREFYHPLVRLRDKVPGYAVSLIKAGVTMEGLPAGPVRPPLVDASPDDVAELQRILAAGRAVIADALVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLS1</accession>
    <name>A0A132PLS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15860</name>
        <name evidence="3" type="ORF">AWC31_16435</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850376.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16435"/>
    <dbReference type="EnsemblBacteria" id="KWX23286">
        <property type="protein sequence ID" value="KWX23286"/>
        <property type="gene ID" value="AFM11_15860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17990">
        <property type="protein sequence ID" value="ORX17990"/>
        <property type="gene ID" value="AWC31_16435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7297"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="392" mass="43111" checksum="28862C738FF8A711" modified="2016-06-08" version="1">MNRPLNFGVFITPFHPVGQSPTTALQYDMDRVEALDRLGYDEAWFGEHHSGGYELIACPEVFIAAAAERTRHIRLGTGVVSLPYHHPLMVADRWVLLDHLTRGRVMFGTGPGALPSDAYMMGIDPVDQRPMMQESLEAILALFRAAPDERIDRKTDWFTLRDAALHIRPYTWPYPEISTAAMISPSGPRLAGALGTSLLSLSMSVPGGYAAVETTWDVVRDQAAKSGRPEPDRKDWRVLGIIHLADTREQAIEDCTYGLQDFANYFGAAGFVPLANEAEVAPSAYEFVENYASKGNCCIGTTADAIAYIQDLLDRSGGFGTFLMLGHDWAPPAATFHSYELFAREVIPHFKGQLTAAQASHDWAKGMRDQLLGRAGQAIVNAITEHTKEGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLY1</accession>
    <name>A0A132PLY1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfonate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850748.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01340"/>
    <dbReference type="EnsemblBacteria" id="KWX23022">
        <property type="protein sequence ID" value="KWX23022"/>
        <property type="gene ID" value="AFM11_16770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.707"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="238" mass="25873" checksum="F1FD5AFA888190AA" modified="2016-06-08" version="1">MTASDVIDLTGLSKTYGDQVILDDFQLTVRKGEFVALLGRSGTGKTTLLRILAGLEDATAGHVSITSRTSVVFQEPRLIQAQRVWKNVALSTSRRGDTYRRALAALDEVGLADKAQSWPKNLSGGEAQRVGLARALVRSPELLLLDEPFGALDAFTRRTAQDLVTTLWQEHRVGVLLVTHDIEEAVLLADRIVVLGKGLVQADLAVDLPRPRDVTSPAFNAIKRQVLDSLGTNVKEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM19</accession>
    <name>A0A132PM19_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="6" type="ORF">AFM11_15910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850393.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16485"/>
    <dbReference type="EnsemblBacteria" id="KWX23294">
        <property type="protein sequence ID" value="KWX23294"/>
        <property type="gene ID" value="AFM11_15910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7307"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="161"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="313" mass="33298" checksum="2F9ABE27F9787A22" modified="2016-06-08" version="1">MTINKAPKFTPGELNVYSAPADVAAVTRALRTSGRRVTLVPTMGALHEGHLTLVRAAKRVPGAVVVVSIFVNPLQFGAGEDLDAYPRTLDDDLEALRAEGVEIAFTPTGSDMYPTGPRTSVHPGPLGEELEGASRPGHFAGVLTVVLKLFQIVRPDRAYFGEKDYQQLALLRQMVADLNVDVQIVGVPTVRESDGLALSSRNRYLDADEREQAGALSAALLAGKYAAAGGADAAVDAARAVLDEVPAIQVDYLQVRDPMLGPAPYEGAARLLVAARLGRTRLLDNIAVDIGASAGIDGHPRVSDDNHELPWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM88</accession>
    <name>A0A132PM88_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_16035</name>
        <name evidence="5" type="ORF">AWC31_16610</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850438.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16610"/>
    <dbReference type="EnsemblBacteria" id="KWX23317">
        <property type="protein sequence ID" value="KWX23317"/>
        <property type="gene ID" value="AFM11_16035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18021">
        <property type="protein sequence ID" value="ORX18021"/>
        <property type="gene ID" value="AWC31_16610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7332"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="3">
        <location>
            <begin position="72"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX18021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="313" mass="32530" checksum="0CDA35DFA8083D60" modified="2016-06-08" version="1">MAGNSQRRGAIRKSGTKKGPPVGSGGVRRRGLEGRGATPPAHMRPNHPAAKKAAKAARQQQGRPRKTDDTELVLGRNPVLECLRAKVPATALYVALGTDADERVTEAVQIAADRGISILEVPRTDLDRMSSNALHQGLGLQVPPYNYAHPEDLLSAAEADATPALLVALDNISDPRNLGAIVRSVAAFGGHGVVIPQRRSASVTAVAWRTSAGAAARTPVARATNLTRTLKSWADAGLQIVGLDAGGDTTLDELDGTGPMVVVVGSEGKGLSRLVRENCDAVVSIPMAGPTESLNASVAAGVVLAEIARQRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMG5</accession>
    <name>A0A132PMG5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14775</name>
        <name evidence="3" type="ORF">AWC31_18125</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849944.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18125"/>
    <dbReference type="EnsemblBacteria" id="KWX23529">
        <property type="protein sequence ID" value="KWX23529"/>
        <property type="gene ID" value="AFM11_14775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17236">
        <property type="protein sequence ID" value="ORX17236"/>
        <property type="gene ID" value="AWC31_18125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7066"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="104" mass="11636" checksum="C57D80936E8C0463" modified="2016-06-08" version="1">MIRRAGSGVARGLIFLIQLYRHTISPLRLPTCRFMPTCSQYAVDALTEYGLIRGGWLATVRLLKCGPWHRGGWDPIPERRPHTCETDVSGETAAADLVRSKSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMH6</accession>
    <name>A0A132PMH6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor SigM</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_14830</name>
        <name evidence="9" type="ORF">AWC31_18070</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849963.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18070"/>
    <dbReference type="EnsemblBacteria" id="KWX23539">
        <property type="protein sequence ID" value="KWX23539"/>
        <property type="gene ID" value="AFM11_14830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17226">
        <property type="protein sequence ID" value="ORX17226"/>
        <property type="gene ID" value="AWC31_18070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7077"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="137"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX17226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="211" mass="23196" checksum="38BD391073A2BC2B" modified="2016-06-08" version="1">MGRFGGASEFAGPVNGRSDAELLAAHVAGDRYAFEELVLRHHRQLRRLAYLTSRHHDDADDAVQDALLSAHRTAASFRFDSSVSSWLYRIVVNACLDRLRRAKTQPGAPSRDELGELDHVRDPAGDPAHRVDTAIVVERALLQLPVEQRAAVVAVDMQGYSVAETARLLGVAEGTVKSRCARARAKLARSLQYFEGDERQPAPSAVRRAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMI7</accession>
    <name>A0A132PMI7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_14685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849908.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18215"/>
    <dbReference type="EnsemblBacteria" id="KWX23513">
        <property type="protein sequence ID" value="KWX23513"/>
        <property type="gene ID" value="AFM11_14685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7046"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="3">
        <location>
            <begin position="16"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="360" mass="36027" checksum="AD354F9054A3538C" modified="2016-06-08" version="1">MGYTGVVWESRSTEQLARDLTEGPGPSSVGDAGAAWVRVANGFNAAATEYTQLLDRVRTSWESQHAPDVLARLQELGDWLQAKALNAAANGQRAEQAAVAATVAILAMPSVSEAVEGEAQRDMMASLAAYNGAVLTGSFAEFDAAATADQANAAAVMQQYENAVAPLATAWEEPLPPEVAKGDAAAAERAAAAAAAGAAGGTAGAGGGGYAPPPMPLGPHAGRGVSGSERPSNSGRVSAVSPAAASTMAGAPYAPMAGLARGQDGGRDHESMYPPEVLEGGGEAAAGLAANGSTWLPATGINDTPILVDSVSWGPDTAAFDGLADPGTAPDEFADDSRTLEQVSDSWVSPAVIGASSEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMU5</accession>
    <name>A0A132PMU5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848968.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02835"/>
    <dbReference type="EnsemblBacteria" id="KWX23635">
        <property type="protein sequence ID" value="KWX23635"/>
        <property type="gene ID" value="AFM11_12575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6605"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="312" mass="33493" checksum="C42AFA43E9F6A0E6" modified="2016-06-08" version="1">MTISVLRTTDGWWVQTRTGATKIATTATSTGELLADRPAVEAAAESEGSVAVEELTLLSPVTAPCRVVAQMTNFESHVRDSGMDPKTMPLTFFRKSSASISGPFDEIVRPAHVSLLDYEIEIGLVIGRDVPVGTRITDANLADYIAGLTITNDVSARDIQLPQTQFYEAKSYPTFTPVGPALVLVDAAELARFGDLRLRLSVSGDERQNALVDGDMLYRPLQALQSLTRFQELAAGDLILTGTPAGTALTAPPKPIEVIGNLLPPAVKWKAFISRQAKNPKYLQHGDVVEASIATDDGALDLGAQRLTVRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMW5</accession>
    <name>A0A132PMW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849031.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03015"/>
    <dbReference type="EnsemblBacteria" id="KWX23655">
        <property type="protein sequence ID" value="KWX23655"/>
        <property type="gene ID" value="AFM11_12695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6629"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="167"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="36150" checksum="598FC16F1B839008" modified="2016-06-08" version="1">MRVLLTGAAGFIGARIAAALRTAGHEVIAVDAMLAAAHRAGTEPPDDCQVVDIRDATALAPLLEGVDVVCHQAAVVGAGVNAADAPSYASHNDFGTAVLLAEMFETGCARLVLASSMVVYGQGGYDCPEHGPVEPLPRSRTDLDNGVFEHRCPVGGEPLRWRLVGEDAPLRPRSLYAASKTAQEHYALAWSDAARASVVALRYHNVYGAGMPRDTPYSGVAAIFRSELESGDVPRVFEDGGQMRDFVHVDDVAAANVAAVEATMDGFNAFNVCSGRPISIMDVATQLCEVRGAPAPVVTGQYRTGDVRHIVADPTRAAEVLGFRAAVDPRDGLTEFAFAPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN05</accession>
    <name>A0A132PN05_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13105</name>
        <name evidence="3" type="ORF">AWC31_03390</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849229.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03390"/>
    <dbReference type="EnsemblBacteria" id="KWX23720">
        <property type="protein sequence ID" value="KWX23720"/>
        <property type="gene ID" value="AFM11_13105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11179">
        <property type="protein sequence ID" value="ORX11179"/>
        <property type="gene ID" value="AWC31_03390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6714"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019719">
        <property type="entry name" value="DUF2599"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10783">
        <property type="entry name" value="DUF2599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453150" evidence="1">
        <location>
            <begin position="29"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="139" mass="14972" checksum="17FE99C6B9B901EE" modified="2016-06-08" version="1">MRLSTAALGAVCFAAALTCVSPVTPAAWAEPATPYVDHVEWAKWGDLSSLRVYPTDTARRLAAQPGTSAEADEAWAQVLALSPDADIAGMREQFLCHWTFAELAEPGKTSWNLEPWRPEVPPEMMLAAGCNPGGTEEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN33</accession>
    <name>A0A132PN33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metabolite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_12820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849089.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23674">
        <property type="protein sequence ID" value="KWX23674"/>
        <property type="gene ID" value="AFM11_12820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6657"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="27"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="446" mass="47604" checksum="E101B50E75B170D6" modified="2016-06-08" version="1">MNLDTSVAAGHGVTLDSARLNGFHAKLALFSSGGPFLDGYILSIIGIAMVQIQPQWDMSALWAGLIGSSALIGVFLGGAVFGPITDRIGRKLMYTIDLVAIIVCSVLQFFAQDVWQLFVLRLIIGIAVGADYPIATALVTESAPKAWRAKLVGGLNAMWFVGATVAAFVGYLLLSLPDGWRWMLLSSAIPAAVIVVARTTMPESPRWLLSKGRSDEALAVLRRTIGAQATFDDLPAEEGTTTIRGLMRGGYLRRVVFISVFWTCTIVTLFAIYAFGPQILELFNLGSGDLAHIGYGLINLFFLIGNIVALLLVDRLGRRPILIWGFVLSGIGLLFLAIRPDAALWMIAIAFAVYALFNGGPSILEWIYPNELFPTEVRATAVGLCTGISRIGAAIGTFATPWALTNLGLSATMYIAAGIAGVGAVVSFLMAPETRGTDLSDAASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN44</accession>
    <name>A0A132PN44_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849274.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03470"/>
    <dbReference type="EnsemblBacteria" id="KWX23735">
        <property type="protein sequence ID" value="KWX23735"/>
        <property type="gene ID" value="AFM11_13185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6730"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="205" mass="21742" checksum="C25A7E230D9A957D" modified="2016-06-08" version="1">MSARLEARGVSVSFGGRRVLDAVGLAVGGGEIVGVTGPSGCGKTTLLRVLAGLRRPDEGEVRYHGSLAPPRQAAVALVAQHPRLVCNPRWTLGRIIAEPATIRRETVTVAAVARRVGLDESLLERYPGQVSDGQLQRACLGRVVVQRPEFLLCDEPTAMLDPIATDDVAKLLHDIAREGASLVLVSHDAELVSALSTRTHVLPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNA3</accession>
    <name>A0A132PNA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849491.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03995"/>
    <dbReference type="EnsemblBacteria" id="KWX23821">
        <property type="protein sequence ID" value="KWX23821"/>
        <property type="gene ID" value="AFM11_13750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6846"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="168" mass="18262" checksum="2E74A41A5E8AFE89" modified="2016-06-08" version="1">MRGDGDGWVISDNGARFWGRHGAAGLLLRAPWPDGSAAVLLQHRAPWSHQGGTWALPGGARDSHETPEQAAVREAHEEAGLPAEQLTVRTTVITAEVAGMGGTQWTYTTVIADAPELLETIPNRESSELRWVVEDQVAELPLHPGFAASWQHLRTVTATIPLLVNRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNC5</accession>
    <name>A0A132PNC5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849479.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03945"/>
    <dbReference type="EnsemblBacteria" id="KWX23815">
        <property type="protein sequence ID" value="KWX23815"/>
        <property type="gene ID" value="AFM11_13700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6836"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453440" evidence="2">
        <location>
            <begin position="23"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="135"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="4">
        <location>
            <begin position="238"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="479" mass="49540" checksum="34B1F73C8208DDF0" modified="2016-06-08" version="1">MRSRWLAAAALAATVAAGCSSAPTPPPTELPHDLAQRITVDGMFAHLRKFAEIADANDGNRGQGTPGYDASLDYVAQLLRDKGFDVSTPEFERLGTMRGGSPNLTVSGRRYPVDQASLLVTTAPGGLNAPTLRPGKPAGCAAADYSGVDIDGAIAVVDDTGCSIVVKQNTALAEGAVGLLVVSTTRPSPAGLFTSGYYGQLKVPVGVIDKTADTALRRTSAPVRLTLDSKADMVKSRNLLAQTKTGSTTDVVMVGAHLDSIAAGPGINDNGTGVAAVLETALQLGGSPQIHNAVRFAFWGAEETGLEGSTQYVRGLQPEQLDELALYLNFDMLGSTNAGYFTYDGDQSAQAGDAKPVPEGSAGIERTIAGYLNLAGVRPADMPLSANTDYGPFVTAGVPIGGATTGSSQRKTEVQARLWGGRAGVAFDPNYHTARDTIDNVDAKALSIMGPAVGFVVGTYALSTDGPNGVPPRDQRHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNH5</accession>
    <name>A0A132PNH5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849599.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03545"/>
    <dbReference type="EnsemblBacteria" id="KWX23880">
        <property type="protein sequence ID" value="KWX23880"/>
        <property type="gene ID" value="AFM11_13260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6745"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="205" mass="22636" checksum="354D4A87EDB644F5" modified="2016-06-08" version="1">MSKSWPSRRGIPPTVRKGDLREQQILDAAETLLTTRGYVHMTVGDIAEAAGITRSALYFYFASKQDILIALVARTVSALQQDSVSALSRAAPIHEVIEAALEHTARQWREHGVVMRAAVDFASTIPEVDRLWTDTAYAISEAVTALLVRGGVPLGDGPDDARALARVLCWMVERSFYQASRISAHELDRTRKSCQSAWLRFVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNL8</accession>
    <name>A0A132PNL8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848988.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23642">
        <property type="protein sequence ID" value="KWX23642"/>
        <property type="gene ID" value="AFM11_12610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6612"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="90"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="222" mass="24325" checksum="E104B2CCAC644996" modified="2016-06-08" version="1">MTDSPVTHQLRDDLSIDQRVALKTAAGRLRGEFDGTFGTETIERFLHSSYDQFAGRASIPHFLPLLAERFARQRLHALARVEGKITDAKPTVLFLCTHNAGRSQMALGFLTHLAGDDAVAWSGGSEPGNEINPAAITAMHEVGIDITGEYPKPWTDEIVQAADVVVTMGCGDACPIFPGKRYENWELPDPAGQGLEAVRPIRDDIEERVRRLLADLNVPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNR2</accession>
    <name>A0A132PNR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848211.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30495"/>
    <dbReference type="EnsemblBacteria" id="KWX23971">
        <property type="protein sequence ID" value="KWX23971"/>
        <property type="gene ID" value="AFM11_11400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6357"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="338" mass="37239" checksum="BBD1461CAE03EBA7" modified="2016-06-08" version="1">MPIYTVLGPIEPSELGETSMHEHLLIDGRVWFEPAREPVPEPPAVSLENLGFVHWNLVSLEDNLLIDDVDLAVRELEYFSGVPNAGLVDLTNIGLGRRIDDLATISKRAGVHVMSGCGFYIHNSHPDYVEQWSVDQLAELLIGELRVGVDGTGIKAALIGEIGTSSPVTEREKKVLAAAGTAAVETQASVSIHLEPRGVEALNVLEILLAQGMSTDRVIMGHLDEHLDKAYHADVAQSGVAMAFDTFGSDFYFSGLFKDPTDLERIDHLLPLLHDGHAEQLVLACDVWTKANLKHYGGFGYDHLHRRILPLLRDEHGVSDDTITQMMVDNPRRLLDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNU3</accession>
    <name>A0A132PNU3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24001">
        <property type="protein sequence ID" value="KWX24001"/>
        <property type="gene ID" value="AFM11_11580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6393"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="227" mass="25312" checksum="A95EB944F504CEC7" modified="2016-06-08" version="1">MSLGADPALDSNTNRTLQAYNDLRTLILSGHYAPDSRLTESELTARLQVSRGTVRSVLARLAQEGYVTAEVNRSARTRSFSVDEAIEILETRAVLESALAAKAAERATDEEIAAMTETCKRMWESQVPGGREEYWRLNRRFHEQVKQAARQSTLTRFVDSLLYPLVVRQYRDEASTAPRIESVREHEAILAGIITHNPEAAAAAMRHHLSSVRRALQLNISAPSDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNV1</accession>
    <name>A0A132PNV1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heparin-binding hemagglutinin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13115</name>
        <name evidence="4" type="ORF">AWC31_03400</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849235.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03400"/>
    <dbReference type="EnsemblBacteria" id="KWX23722">
        <property type="protein sequence ID" value="KWX23722"/>
        <property type="gene ID" value="AFM11_13115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11181">
        <property type="protein sequence ID" value="ORX11181"/>
        <property type="gene ID" value="AWC31_03400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6716"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="218" mass="23206" checksum="35F83D68F2C2D553" modified="2016-06-08" version="1">MADKTTAKNQPTIEDLKAPLLAAVGAADLALATVNEIVASLRERAEEARTDAETRVEESRARLNRLQEDLPVQFGELREKLSSDELRRAAESYADQATATYNKLVERGEAALERLRNQPALEEAATRVEGYTDQAVELTQEALGTVASQTRAVGERAAKLVGVELPKKAEKAGEKATAPAKKAAPAKKTTPAAKKAAPAKKATPAATKAAPAKKVTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP37</accession>
    <name>A0A132PP37_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_11925</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848500.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10050"/>
    <dbReference type="EnsemblBacteria" id="KWX24063">
        <property type="protein sequence ID" value="KWX24063"/>
        <property type="gene ID" value="AFM11_11925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6465"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00111"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="4"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="306"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX24063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="472" mass="52360" checksum="37AB3CA99DD80738" modified="2016-06-08" version="1">MKRLSGWDAFLLYTETPNVHMHTLKIAVIDLEGIGDRTFGVDDFRKVLHGRLYKLDPFRYQLIDIPFKFHHPMWRENCDVDLDYHVRPWRLPAPGGRRELDEAIGAIASTPLDRSRPLWEMYFVEGLANERIAVVGKIHHALADGIASANLLARGMDLQEGPQRDRDSYATDPAPSKSELVRSAFRDHLRQIGRLPGTIRYTAEGVGRVRRSSRKLSPELTRPFTPPPSFMNHVLTPRRLFATATLALSDVKETSKKLGITINDLVLSMSSGALRTLLLKYDGKADHPLLASVPMSFDFSPDRISGNRFSGVLVALPVDEADTAERVRKAREAAGLAKESHQLIGPELIARWAAYIPPAPVEAAFKWLSGKDGQNKVLNLNISNVPGPRERGKVGGATVTEIYSVGPITAGSGLNITVWSYVDQLNISVIADDATVDDPHEVTDAMLDEFRDIRRCAGLPDKLTIVETAMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPA9</accession>
    <name>A0A132PPA9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PepX_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848846.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24171">
        <property type="protein sequence ID" value="KWX24171"/>
        <property type="gene ID" value="AFM11_11450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6366"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="335"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="571" mass="63121" checksum="A05F8BBBED500A70" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPG1</accession>
    <name>A0A132PPG1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847151.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05695"/>
    <dbReference type="EnsemblBacteria" id="KWX24229">
        <property type="protein sequence ID" value="KWX24229"/>
        <property type="gene ID" value="AFM11_09530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5943"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="422" mass="46294" checksum="D9DA3D0439120F76" modified="2016-06-08" version="1">MSVSPITPLSQRAYDPVDLSSRKFWATTAAERENAFAELRAARPVSWHPPVEDALMHDPNDQGFWAVTRHADIVAISRDSETFLSGKGVLFENVPEELLEASQSFLAMDAPRHTLIRKLVHAAFTPRQVARIETSIKANARQIVAELKTAGSGVDFVDQCAKELPIRTLSDMVGIPESHRQQVAHAADALVSWADPVYLDGRNPLEVLLENQVYLHQVAGELAAQRRAQPGHDLISALVQAEVDGDRLTDAEVAAFFVLLAVAGNDTTRQATSHALKALTDFADQRAWLMADFDDRIGCAVEELVRWATPVMTFRRTAATDVEIGGRKIAAGDKVVMFYASGNWDTAVFDRPEVLDLSRKPNPHLGFGGGGRHFCLGAHVARTQLRALFAELLHQLPDIAAGEPAYLQGNFVHAIRAMPCTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPR9</accession>
    <name>A0A132PPR9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847353.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05315"/>
    <dbReference type="EnsemblBacteria" id="KWX24293">
        <property type="protein sequence ID" value="KWX24293"/>
        <property type="gene ID" value="AFM11_09910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6018"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="393" mass="42527" checksum="FBDA427124E193DD" modified="2016-06-08" version="1">MPEMSTIAGSCAPEFGAVRDAFEQNFAERGEIGAAVAVWVEGDLVVNLWGGRADAAGARPWREDTLASVFSGSKGLTSTCVHLLADRGELDLNAPVARYWPEFAQAGKEDITIAMVLGHRSGVIGPREPMDWREVTDWDGVCERIAAAEPWWEPGTAQGYHVVTFGFILGEVIRRVTGRTLGQYLRTEIAEPLGIDVHIGLPAAEHHRCAEMVNKPTVQGLLADSGFVAPPDTLDVHPMAGWAVSMNFVPDDELGVHSLDTWRSAEFPSTNAHVSALGMATFYNALAQEKLLSREHMELCRVSQGGFDTDVVLGPRVADHGWGLGYMLNQRGVAGPNTRIFGHGGSGGSFAFVDLEHRIGYAYVMNYFDATKCNADPRTVALSNEVYSALGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPY7</accession>
    <name>A0A132PPY7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cro/Cl family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_10160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847488.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24334">
        <property type="protein sequence ID" value="KWX24334"/>
        <property type="gene ID" value="AFM11_10160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6068"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026281">
        <property type="entry name" value="HTH_RamB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018653">
        <property type="entry name" value="ScfR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09856">
        <property type="entry name" value="ScfRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019251">
        <property type="entry name" value="Rv0465c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="469" mass="51891" checksum="9BBA022CE602FD29" modified="2016-06-08" version="1">MAKTFAGARLRRLRDDRGLTQVALARALGLSTSYVNQLENDQRPITVPVLLALADRFDLPTHYFAPDADARLVSDLREALSEHPATAAQIEELVARMPEIGHTLVSLHRRLHDATAELEAVHGRANLDTATGGQPPMPFEEVRDFFYDRRNYIDELDRVAEELFARHRLRTGGLDGQLAEVLSETHGVTVVIDDGDVLAPNMKRRYRPDVGALYVARWLHPGQRAFQLATQLALLMHSDLIAAIVATDDKLSPEARDVARIGLANYFAGAVLLPYGMFLRAAEELRYDIDQLARRFEVGFETVCHRLSTLQRPDARGVPFIFVRTDSAGNISKRQSATAFHFSRVGGNCPLWVVHHAFSRPGEFLTQVAQMPDGRSYFWVAKTSPSTPVRYLGTPKRFAIGLGCDLAHADKLVYSVGIDLGDPAATVPIGAGCRICDRPACPQRAFPYVGRPVQVDPQTSSDLPYPPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQD4</accession>
    <name>A0A132PQD4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemoglobin GlbO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847934.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18545"/>
    <dbReference type="EnsemblBacteria" id="KWX24484">
        <property type="protein sequence ID" value="KWX24484"/>
        <property type="gene ID" value="AFM11_10060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6048"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="131" mass="15410" checksum="90611D9930135D74" modified="2016-06-08" version="1">MTAAQRSFYDEVGGHDTFRAIVSRFYQLVREDEILHPLYPEDDFDGAEERLRMFLEQYWGGPRTYSDQRGHPRLRMRHAPFRIGYLERDAWLRNMHIAVGEIDSATLDDPHRKALLDYLEMAADSMVNSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQF0</accession>
    <name>A0A132PQF0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_07675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846066.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22170"/>
    <dbReference type="EnsemblBacteria" id="KWX24556">
        <property type="protein sequence ID" value="KWX24556"/>
        <property type="gene ID" value="AFM11_07675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5384"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453499" evidence="1">
        <location>
            <begin position="25"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3471" evidence="3">
        <location>
            <begin position="444"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="537" mass="57095" checksum="4C5F20B6AAA4FBAE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQH2</accession>
    <name>A0A132PQH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_07800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846131.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24410"/>
    <dbReference type="EnsemblBacteria" id="KWX24578">
        <property type="protein sequence ID" value="KWX24578"/>
        <property type="gene ID" value="AFM11_07800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5411"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="370" mass="41947" checksum="88709971A6940BD7" modified="2016-06-08" version="1">MTDSLIRPFRIAVPDADLDDLKQRLSRTRWPEPECVDDWTQGIPLSYTRDLAEYWATEYDWRSREAALNRFDHYTTEIDGLDIHFIHQRSTREDAFPLVITHGWPGSIVEFHKVIEPLTEAGFHVVCPSLPGYGFSGKPTTTGWGIGKIAQAWDTLMARLGYERYGAQGGDWGAAVTTQIGRNVGNCVGIHVNMPIAQPPAEGVGEMTEDLQKALARIDYYRKWDSGYMKQQSTRPQTVGYGLVDSPVGQLAWIVEKFWSWMDCDGHPENVLSRDELLDNVMLYWVTASAASSARLYWESHDTFGAGDYVTLPTGVASFPKEILRAPRSWCETSYNVTHFTTMPRGGHFAAFEQPELYVEDVRTFFDTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQJ7</accession>
    <name>A0A132PQJ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_07975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846214.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24575"/>
    <dbReference type="EnsemblBacteria" id="KWX24609">
        <property type="protein sequence ID" value="KWX24609"/>
        <property type="gene ID" value="AFM11_07975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5445"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="557" mass="59191" checksum="0678A661B6455BC1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQT7</accession>
    <name>A0A132PQT7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pstB</name>
        <name evidence="5" type="ORF">AFM11_08500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846486.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00355"/>
    <dbReference type="EnsemblBacteria" id="KWX24698">
        <property type="protein sequence ID" value="KWX24698"/>
        <property type="gene ID" value="AFM11_08500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5548"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="28069" checksum="DA151D09E5C3170B" modified="2016-06-08" version="1">MAKRLDLKDVNIYYGSFHAVADVALSVQPRSVTAFIGPSGCGKSTVLRTLNRMHEVIPGARVEGSVLLDGEDIYGAGVDPVGVRKTIGMVFQRPNPFPTMSIRDNVVAGLKLQGVRNKKTLDEVCERSLKGANLWNEVKDRLDKPGGGLSGGQQQRLCIARAIAVQPDVLLMDEPCSALDPISTLAIEDLISTLKLDYTIVIVTHNMQQAARVSDQTAFFNLEATGKPGRLIEIDDTEKIFSNPNQKATEDYISGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQV8</accession>
    <name>A0A132PQV8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Abortive phage infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846542.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13740"/>
    <dbReference type="EnsemblBacteria" id="KWX24721">
        <property type="protein sequence ID" value="KWX24721"/>
        <property type="gene ID" value="AFM11_08630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5576"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015837">
        <property type="entry name" value="UCP026622_CAAX_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026622">
        <property type="entry name" value="Proteas_026622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="215" mass="21899" checksum="767E459DA9FC7C53" modified="2016-06-08" version="1">MRGKQLRAVALAAGMVAWNGLVDPRLPARWQPLVRALTGTGLLVLTGSRPALRPPALWSGLQLGAAAAGALTAGVAATTAVPAVRAEMVLRELPPAAAWLLLRIPVGTVWSEEAAFRAALSTVGATAFGPEGGQLLQAAAFGLSHIADARATGEPVIGTVLVTGVAGWGLGWLARRSGSLAAPILAHLAINEAGAIAAFACQRGPAALQRLRRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRE6</accession>
    <name>A0A132PRE6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846682.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13455"/>
    <dbReference type="EnsemblBacteria" id="KWX24767">
        <property type="protein sequence ID" value="KWX24767"/>
        <property type="gene ID" value="AFM11_08915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5632"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="794" mass="84150" checksum="F4A94FB93B69D3EB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRF5</accession>
    <name>A0A132PRF5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_05565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845024.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12940"/>
    <dbReference type="EnsemblBacteria" id="KWX24910">
        <property type="protein sequence ID" value="KWX24910"/>
        <property type="gene ID" value="AFM11_05565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4303"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="137"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="241"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="421" mass="45661" checksum="B53AB2B980695791" modified="2016-06-08" version="1">MTETVSTSATTESVEEFARRARQWLAENMPPIDPDNPPFAVRAEAESWERAKDLQKRLYEGGFAGICFPREYGGLGLDYAYQKAFNDECIRYEMPLILNTPSFTICAATILDMGSEAQKRERISAAIRGDEILVQLLSEPNGGSDLAGVITRADRRDDGTWVINGAKTWSTSAFAGDYGLMLARTDWTVPKHEGLTMFLVPLAAPGITMRRIKEVNGNEEFCEEFFDGLELPADAVVGEVNDGWTVASRQLHHERRAVGGGSEFASGTGAENANEMPPDHVGLAEATGQGDDARVQDLAGRTLARRIVKKQLIDHVGRAIGNGSLPPNAGTLIRLFHAETTELEVDTALAIAGTAGVVDEGDELSGMLDIGVRYLSRQTGSLGGGSSEMARNVIGERILGFPREFAADRGVPFNQVKRNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRY7</accession>
    <name>A0A132PRY7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845368.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29035"/>
    <dbReference type="EnsemblBacteria" id="KWX25093">
        <property type="protein sequence ID" value="KWX25093"/>
        <property type="gene ID" value="AFM11_06640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4526"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="576" mass="62533" checksum="C51A87C35F14D39B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS37</accession>
    <name>A0A132PS37_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpC</name>
        <name evidence="10" type="ORF">AFM11_06945</name>
        <name evidence="11" type="ORF">AWC31_28705</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845511.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28705"/>
    <dbReference type="EnsemblBacteria" id="KWX25149">
        <property type="protein sequence ID" value="KWX25149"/>
        <property type="gene ID" value="AFM11_06945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13775">
        <property type="protein sequence ID" value="ORX13775"/>
        <property type="gene ID" value="AWC31_28705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4588"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_A">
        <property type="entry name" value="IGPS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="7"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX13775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="272" mass="28379" checksum="B66B8BFD71A47F6B" modified="2016-06-08" version="1">MSSATVLDSIIEGVRADVAAREAVTSLAEIKERAKAAPAPLNVMAALREPGIGVIAEVKRASPSRGELANIADPAELAQAYQDGGARVISVLTEQRRFNGSLDDLDAVRAAVSIPVLRKDFIVKPYQIHEARAHGADMLLLIVAALDQSVLESLLERTESLGMTALVEVHTEEEADRALQAGATVIGVNARDLKTLEVDRDCFARIAPGLPSNVIRIAESGVRGTADLLAYAGAGADAVLVGEGLVTSGDPRSAVADLVTAGTHPSCPKPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS40</accession>
    <name>A0A132PS40_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08090</name>
        <name evidence="2" type="ORF">AWC31_00025</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000001">
        <property type="protein sequence ID" value="ORX19346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00025"/>
    <dbReference type="EnsemblBacteria" id="KWX24842">
        <property type="protein sequence ID" value="KWX24842"/>
        <property type="gene ID" value="AFM11_08090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19346">
        <property type="protein sequence ID" value="ORX19346"/>
        <property type="gene ID" value="AWC31_00025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5468"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX19346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="65" mass="7147" checksum="E1680C5D5411C8A4" modified="2016-06-08" version="1">MWGVADKKKKQYVDNGWPVLSDGDDHAVSELVSDRTGSLSPFGDITFPLPAEELPFVQSVTVVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSP6</accession>
    <name>A0A132PSP6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845285.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29295"/>
    <dbReference type="EnsemblBacteria" id="KWX25052">
        <property type="protein sequence ID" value="KWX25052"/>
        <property type="gene ID" value="AFM11_06380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4470"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="175" mass="19193" checksum="D5E36D1ED6355535" modified="2016-06-08" version="1">MVTIPAFVWHGGFLYRALITGLSVGLCLGVLAWLDSGFFLAGALAFVVVGIFYGTWMPMRMARYWPMAQQLDGAQRVALVRAARRGIRLDDPRLAEAATGYRQGMHAAVEAARPLRWVLLLVLGVAVATAVWDAVFGSVGNAVVSFVYLVLLLVEIFWWPKRQAQLLANVDRACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSV7</accession>
    <name>A0A132PSV7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25277">
        <property type="protein sequence ID" value="KWX25277"/>
        <property type="gene ID" value="AFM11_02970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2459"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="323" mass="35854" checksum="9A275C708A0CA6A2" modified="2016-06-08" version="1">MLWLVEPLTRWSSLSDQITLASELFGPVAGAEKVATWLAEQMSLVDNVDFAQEFAAHVQLPGIEVVDYAHRHIRSTRGELLGGIRFYSRNTARPFVDVLAHNFDDIDALTDCVLREWSAFNVAYLRLRTAPGLLTDRLDVLLDETIRVARYRDMAPADGRVTLEQFDDPEHAIALVDARYATLAATDSTLANNLSVAAPEDLRHWHHSDQLRAIRRHDTTIGALAIVPGAIGWITGEEINEEVITKRHNGHRYAASAQTAWARDIATDTDQLLIGTIDRHNHASRATAQRAGRPRALDDVFIALAASSTPSRRDKNGSDLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT04</accession>
    <name>A0A132PT04_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Resuscitation-promoting factor RpfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_04050</name>
        <name evidence="5" type="ORF">AWC31_21105</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844340.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A132PT04"/>
    <dbReference type="STRING" id="59750.AWC31_21105"/>
    <dbReference type="EnsemblBacteria" id="KWX25440">
        <property type="protein sequence ID" value="KWX25440"/>
        <property type="gene ID" value="AFM11_04050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16534">
        <property type="protein sequence ID" value="ORX16534"/>
        <property type="gene ID" value="AWC31_21105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2688"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="205"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX16534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="375" mass="39500" checksum="A2AD9BA2CE74C40A" modified="2016-06-08" version="1">MDALNKIHESRSPLLRGVVGALLVTLTAAGGYAVSSHKTVTLSVDGSPMTVTTMKSRVIDVVEENGFDVGERDDLYPAAEQAVHQSDTIVLRRSRPLQLSLDGQDSKQVWTTASTVDEALAQLRMTDKAPAAASRGSRVPLAGMALPVVSPKTVQIDDGGVVSTVHLAAPNVAGLLRAAGVPLEQNDTVVPAASSPVIDGMQIQVTRMRIEKVTERVPLAPGNKRIEDVTLNMSRQVVEDPGAPGTQDVTFAVAKVNGVETGRLPVANVVINPARDGVLRVGAKPGTEVPPVTNAAAWDALAQCEAGGNWAINTGNGFYGGVQFDQNTWERSGGLRYAPRADLATREEQIAIATVTQARQGWGAWPVCSGRIGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT33</accession>
    <name>A0A132PT33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04235</name>
        <name evidence="3" type="ORF">AWC31_20920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844438.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20920"/>
    <dbReference type="EnsemblBacteria" id="KWX25470">
        <property type="protein sequence ID" value="KWX25470"/>
        <property type="gene ID" value="AFM11_04235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16503">
        <property type="protein sequence ID" value="ORX16503"/>
        <property type="gene ID" value="AWC31_20920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2724"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="90" mass="9604" checksum="DEBF28E96BFC7484" modified="2016-06-08" version="1">MSQQTGEPYDPLRLCVYATVALLAWLLGPWAVAAFAVLGLAGYIRARRAGLLHSKCVLRDTRLVIGYLGIIAAIAIAGIVVSYLPQQPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTE5</accession>
    <name>A0A132PTE5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_03275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843920.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21810"/>
    <dbReference type="EnsemblBacteria" id="KWX25322">
        <property type="protein sequence ID" value="KWX25322"/>
        <property type="gene ID" value="AFM11_03275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2530"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="93"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="316" mass="35151" checksum="B5FA6B1D5467B718" modified="2016-06-08" version="1">MTTLERETETEAQHVARIKQKQDLGVSRAEGWRRRGPLLPALIFMIVVTQIPFLFTLYYSTLSWNLVRPGSRQFVGLQNYLDVVGDSVFWQVALNTVWIIVATVLISVVLGLLLALLLDRAFLGRGVVRTLLITPFLVTPVAGALMWKTAMLDPVFGIVNWVLPGPDIDWVSRFPVSSVILALVWQWTPFMMLLILAGLQSMPRDILEAGRVDGAGAFQLFRELTLPHLRRFIELGAVLGAIYLVNTFDQIYMITQGGPGTASANLPFYIYQRAFLGFDIGQAAAMGVIVVIFTMVIASFALRLIFKSFTGKEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTG3</accession>
    <name>A0A132PTG3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_04765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844620.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20380"/>
    <dbReference type="EnsemblBacteria" id="KWX25554">
        <property type="protein sequence ID" value="KWX25554"/>
        <property type="gene ID" value="AFM11_04765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2834"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="281"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="405" mass="42604" checksum="753443EA9EA64B6A" modified="2016-06-08" version="1">MSEAVIVATARSPIGRANKGSLVDMRPDDLAAQMVKAVLDKVPALDPRDIDDLIMGCGQPGGESGFNIGRAVAVQLGYDFLPGTTVNRYCSSSLQTTRMAFHAIKAGEGHAFISAGVETVSRFAKGNADGWPDTKNPVYADAMARSDQAAAGAEEWHDPREDGLIPDVYIAMGQTAENVALHTGISREDQDHWGVRSQNRAEEAINNGFFEREIVPVTLPDGTVVSKDDGPRAGTSYEKISQLKPVFRPNGTVTAGNACPLNDGAAALVVMSDERARDLGLTPLARIVSTGVSGLSPEIMGLGPIEAVKKALANAGMTIGDIDLYEINEAFAVQVLGSARALGMDEDKLNVSGGAIALGHPFGMTGARITATLLNNLQTYDKTFGIETMCVGGGQGMAMVVERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTS3</accession>
    <name>A0A132PTS3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25664">
        <property type="protein sequence ID" value="KWX25664"/>
        <property type="gene ID" value="AFM11_03380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2550"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="46"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="29760" checksum="DC2E6AE1CD7E547D" modified="2016-06-08" version="1">MESVTTAALEPYEVLAVRYGVWHTTMRQIYHSFDVYHEPDAPVQIDYFFWVVRNSRRTVVVDTGFRPEVALRRGRELVTPVPEALARAGVDPAAVSHVVLTHFHYDHIGNLDLFGQAQVVAGATEYEFWTSEIAEQPIFATAVEADEVDVVRKAMVDERLTLVPREDPAIPGLSFREVTGHTPGQIVVEVETAGRPVILASDASHMYEEFEKERPFHIASSLPEMYAGLKWLRTRSRDAEVVPGHDPAVMRRFPVDADGIIARIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTY5</accession>
    <name>A0A132PTY5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="7" type="ORF">AFM11_00450</name>
        <name evidence="8" type="ORF">AWC31_33565</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842245.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33565"/>
    <dbReference type="EnsemblBacteria" id="KWX25801">
        <property type="protein sequence ID" value="KWX25801"/>
        <property type="gene ID" value="AFM11_00450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11615">
        <property type="protein sequence ID" value="ORX11615"/>
        <property type="gene ID" value="AWC31_33565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.91"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX11615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="132" mass="14443" checksum="3BCBA6594A8C5C0A" modified="2016-06-08" version="1">MTMTDPIADFLTRLRNANSAYHDEVTLPHSKIKANIAEILKKEGYINDYRTEDARVGKSLIVSLKYGPSRERSIAGLRRVSKPGLRVYAKSTNLPRVLGGLGVAIISTSSGLLTDRQAARQGVGGEVLAYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUA3</accession>
    <name>A0A132PUA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842588.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34145"/>
    <dbReference type="EnsemblBacteria" id="KWX25916">
        <property type="protein sequence ID" value="KWX25916"/>
        <property type="gene ID" value="AFM11_01105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.227"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="346" mass="37459" checksum="26102560C08A8B8B" modified="2016-06-08" version="1">MRTGIFLSYAGGFKEAADQVVELEKVGVDIALVAEAYSYDAISQLGYLAAKTSTIELGTGVVPIYTRTPSLLAMTAAGVDYVSDGRFRLGIGTSGPQVMEGFHGVPFDAPLGRTREVVEICRQVWRRENVHYDGKYYQLPLPADRGTGLGKSLHLINHPVRERIPITIAALGPKNVELTAEIAEGWQPVFYFPEKADDVWGEALRAGFAKRDAELGPLDVMVSASLAIGDDVDDRLAWAKPQLALYIGGMGARGKNFYHNLATRYGFGEVADRIQDLYLAGKKAEAIDAVPDELVRNVSLVGPKGFVKERLAAYAEAGVTTLLVHPLASDSAESVRFCAELVSLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUF7</accession>
    <name>A0A132PUF7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ORF">AFM11_01295</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842684.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34330"/>
    <dbReference type="EnsemblBacteria" id="KWX25945">
        <property type="protein sequence ID" value="KWX25945"/>
        <property type="gene ID" value="AFM11_01295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.265"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="198"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX25945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="519" mass="55635" checksum="50843164FF597DA4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUP0</accession>
    <name>A0A132PUP0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842500.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33960"/>
    <dbReference type="EnsemblBacteria" id="KWX25887">
        <property type="protein sequence ID" value="KWX25887"/>
        <property type="gene ID" value="AFM11_00930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.192"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="95" mass="9773" checksum="7EF662EB6EADE9D2" modified="2016-06-08" version="1">MSTASSAAERVDRVVEAVTAVDGVIGLHFGPGVPETHLPGRTVRGIRLGADRGQVHVVLELRAGLLDTADRVRDAASTAARVPVDVVVGDVTAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUW9</accession>
    <name>A0A132PUW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25957">
        <property type="protein sequence ID" value="KWX25957"/>
        <property type="gene ID" value="AFM11_01380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.283"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="256" mass="26951" checksum="A3C7F8560B55619B" modified="2016-06-08" version="1">MDGLRVHEQPLNLAGQRAVVTGASRGIGRAVAELLAVRNADVILLARSRSDLEEVEREIATRGGRATSLAVDINDDNALHGVFGSIGPVDILVNAAGANRPKPFLDVSGDDLDALINLNLRAMFRVSQFFVRNVVERGSKGVIVNISSQMGHVGAPDRSVYCATKHGVEGLTKALAIELAPKRVRVVSVAPTFIETAMTRTFLADPDTYRSLVSKIPIGRLGTLAEVAEAVAFAASPAAALVTGSSILVDGGWVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV00</accession>
    <name>A0A132PV00_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_02580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843346.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35355"/>
    <dbReference type="EnsemblBacteria" id="KWX26143">
        <property type="protein sequence ID" value="KWX26143"/>
        <property type="gene ID" value="AFM11_02580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.529"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="369"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="537" mass="58531" checksum="5FB8031DCFE00694" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV64</accession>
    <name>A0A132PV64_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26210">
        <property type="protein sequence ID" value="KWX26210"/>
        <property type="gene ID" value="AFM11_00310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.63"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="494" mass="54461" checksum="48DF181335483C7F" modified="2016-06-08" version="1">MGAWWFGRTPTVRLVLRWALIAVLTIVAFRASLRNLIDTTLAGGLIGYVWMVPIAALLAALGVNYRRRTELPIHDRQTDIIVGVIGLGLALMVQGVLLKRYSEFFHLMRLDLLAMWLFVLSCSFVLFGLRPVARFGWVWVLLSLISALPYQVVVITLGGGNFAAGVGTLFIAAAATAIAVGRTRKRAAVGALTSFVIGFVVLFVLDKVRPDAPVIAYQMIPSLTSILVVGFAAFLYTRRGQPKRLWDRKIEPLAAKQIWSAVPLVVAVAVALAFMPLPKQLSATTISRAAPYELDPGRRLAQPPGWSITGEQTYTGVSRYYGDEAVLVRQRMTADVGDPRFDKLAAPRTVMVDSIVSELPFSFDAYPGQVLYDTTGTRLSAPRRVDLGHGVTGQLLSAIDDRLLVTWDVLRFAWGDEDQDQIVDVFAVDNHLPDAPFPDPQRGLISTLRNLLTVLFRGNSVLVQRQPVYKDAELLTEFGRALVAEQFEQTRTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV86</accession>
    <name>A0A132PV86_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_01510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843626.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26246">
        <property type="protein sequence ID" value="KWX26246"/>
        <property type="gene ID" value="AFM11_01510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.309"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="197" mass="21540" checksum="8740372234647305" modified="2016-06-08" version="1">MVDRPKPDRQVRGAKLRALVLDATIARIEEVGIDSVRIADIAEAAGVHETSLYRRWKTLSRLLVDALVSRTAAEIPIPDTGSVESDLETFTADLARFAQTRAGTAMIRSTVVSDTDPEVEAARREFWLQRLSAAEEIIKRGITRGEVAADTDAQLVVLTLGGLVHLYVSHIGDPIPADLPQRVVRLVLPGITQKWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVE3</accession>
    <name>A0A132PVE3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843325.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35325"/>
    <dbReference type="EnsemblBacteria" id="KWX26137">
        <property type="protein sequence ID" value="KWX26137"/>
        <property type="gene ID" value="AFM11_02550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.523"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="31097" checksum="397F76AC1F7E1C2B" modified="2016-06-08" version="1">MSDENTGDTRKETPDNDTVIPYPGHTSDMAQQPRDEMRDYVGRGLLEGKRALITGGDSGIGRAVAVAFAKEGADVAIAYLEEHDDATHTASLVEDAGRRCLRLPGDLSEVDQCRAIVTKTAGALGGIDILVNNVAYQEPTADLTAISDEQWRHTFAVNIDSFFHVTKAALAHMPEGGAIINTASINGLRGNKTLIDYSATKGAVIALTYSLAQSLTDRGIRVNCVAPGPVWTPLIPATMDAERVESFGEQAPFGRAAQPDEIAPSYVFFASGQLSSYYSGEVLAPIGGETLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVZ8</accession>
    <name>A0A132PVZ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PaaX domain-containing protein, C-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_00035</name>
        <name evidence="5" type="ORF">AWC31_33140</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843537.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33140"/>
    <dbReference type="EnsemblBacteria" id="KWX26202">
        <property type="protein sequence ID" value="KWX26202"/>
        <property type="gene ID" value="AFM11_00035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12084">
        <property type="protein sequence ID" value="ORX12084"/>
        <property type="gene ID" value="AWC31_33140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453339" evidence="1">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="3">
        <location>
            <begin position="191"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX12084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="237" mass="26412" checksum="B515C31C491D332E" modified="2016-06-08" version="1">MTARSVVLSVLLGAHPAWASAAELVQLTADFDIREPTLRVALTRMVSAGDLVRSEDGYRLSDRLLVRQRRQDDAIDPKLRAYDGSWLTLVITSVGTDARTRASLRNTLQQCRFAELREGVWMRPDNLDQVLPAEITDRVRVLHTRDDEPAELAATLWDLPDWTGTAGWLLDEMSSATDVPGRFQAAAGIVRHLLTDPVLPGELLPADWPGTALRKAYKDFAAELVARRDRTELMEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB01</accession>
    <name>A0A132PB01_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_35625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859875.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02625"/>
    <dbReference type="EnsemblBacteria" id="KWX19503">
        <property type="protein sequence ID" value="KWX19503"/>
        <property type="gene ID" value="AFM11_35625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5860"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX19503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="409" mass="44989" checksum="ED54DDE3E2A157EB" modified="2016-06-08" version="1">MRETLDAVWRMEAAKIVATMTRVVGDVGFAEDLAQEALVDALTQWPQTGVPRNAGAWLTTVAKRKAIDHWRRQENLDAKYGELARELADHVDEAWDPDRIDDDVLRLIFIAAHPVLSREAQIALTLRMVGGLSTEEIARAFLTSKATMAARITRAKKALSAANAPFEVPPREEYPRRLTAVLAVIYLIFNEGYSASFGHRWIRDELCTEALRLGRVLAALVPDEPEVHGLLALMEFQSSRFGARTDVDGRPILLEDQNRARWDRAQIGRGVAALERANSTRQQRGSGWGPYALQAALAECHAVAPTAADTDWNRIVALYDALLQIAPSPVVQLNRAVAVAMSSGPAEALAIVDGLDGLDNSYLLPSVRGELLSRLGRPDEAAAEFSRAASMTDSEREREVLLDKASRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB76</accession>
    <name>A0A132PB76_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin-like protein NrdH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Electron transport system for the ribonucleotide reductase system NrdEF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859679.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19579">
        <property type="protein sequence ID" value="KWX19579"/>
        <property type="gene ID" value="AFM11_35180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5765"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011909">
        <property type="entry name" value="GlrX_NrdH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02194">
        <property type="entry name" value="GlrX_NrdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="82" mass="9066" checksum="D3DB27A36A512E7F" modified="2016-06-08" version="1">MTITLYEKPACVQCTATKKALEKANIEYLVVDITQDDEAREYVMALGHLQAPVVVAGDEHWSGFRPDRIKSLTKSAEIAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBD0</accession>
    <name>A0A132PBD0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859774.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19557">
        <property type="protein sequence ID" value="KWX19557"/>
        <property type="gene ID" value="AFM11_35300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5790"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="96" mass="10805" checksum="D7EC8BAC22448419" modified="2016-06-08" version="1">MPRNTPTATERRTSKVDAAEQPDEVTDPKGGRPVQARLTADVARKFDAVARARGMKDSDLVRYAINLMLKEAASDLDKLQETMMRDFEEARRLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBH4</accession>
    <name>A0A132PBH4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859401.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22255"/>
    <dbReference type="EnsemblBacteria" id="KWX19681">
        <property type="protein sequence ID" value="KWX19681"/>
        <property type="gene ID" value="AFM11_34685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5284"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="284" mass="31247" checksum="22029564FBFFBB8F" modified="2016-06-08" version="1">MSSMWHGCLADTDYFEMRSSGGHNYGIWVTTPPGYDRASTRAPVVYVLDGNWAVGMTAPLIVTQMDPMQRIQPYIQVSVGYAGEEAQDWDRLRNRDFVPPGEPIAKELIDAVEMGVQAGARTPEEADAYLAQLRDTHADVFLSFLAAELHPRIEHDYGTATSGHGLFGYSYGGLFTLYAWLTGNTLFESIGAGSPGVVADDSQIFAQLHEMGDSRRAAKLHVTLNDRELLGDLAVYQSLAKNTATVLHRLTSRSEAVTSEILHETHVTGLQASFLSYLRTCRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBN9</accession>
    <name>A0A132PBN9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859357.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19667">
        <property type="protein sequence ID" value="KWX19667"/>
        <property type="gene ID" value="AFM11_34600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5266"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="335" mass="35251" checksum="B0F8744A644DBFA9" modified="2016-06-08" version="1">MTISNTTNTSLAAVANFPPNYFLENIAVRSDGSILVTALNHSELWYLPAPTSTIPVEPILIATLDGLTMGIVETEPDIFYVGTLGDPALYRFDFRGWTPGGAVPSSRVLTFAPDSAGPNGACLLAPNVILVADCVEGVIWRVDLSDDGLSATAKPWLQHASMAPSYTDPFAPVVLSATVQIPMPGVNGVRYAASTGHLYYTGSAAESVLRVSVDPRTYEPKGAPELIAEGIHAVDDFCLDERSGVAYITTHIDNTIHRVPLQPGRGPESAIVAGDPFTDSLVGPSSIVWGRAPGDYGRVAYVTTDGGHAKPPADGIVRPAQVVRLALGDKTVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC19</accession>
    <name>A0A132PC19_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tripartite tricarboxylate transporter TctA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33875</name>
        <name evidence="3" type="ORF">AWC31_07510</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858921.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07510"/>
    <dbReference type="EnsemblBacteria" id="KWX19844">
        <property type="protein sequence ID" value="KWX19844"/>
        <property type="gene ID" value="AFM11_33875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10027">
        <property type="protein sequence ID" value="ORX10027"/>
        <property type="gene ID" value="AWC31_07510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5113"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="514" mass="54219" checksum="C25C44B324A7568B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC30</accession>
    <name>A0A132PC30_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="12" type="ORF">AFM11_33400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858678.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02315"/>
    <dbReference type="EnsemblBacteria" id="KWX19878">
        <property type="protein sequence ID" value="KWX19878"/>
        <property type="gene ID" value="AFM11_33400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5012"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="275"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="398"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="410"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX19878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="656" mass="70854" checksum="2AD1C3CA48604E54" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC37</accession>
    <name>A0A132PC37_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858708.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19889">
        <property type="protein sequence ID" value="KWX19889"/>
        <property type="gene ID" value="AFM11_33460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5023"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="96" mass="10901" checksum="625105276B6F8607" modified="2016-06-08" version="1">MALAGSAVAVGVAATQAHPTSRTRTAITRAKIVRRHVARAHADHERNVSRRNRVFPTQAIHVRRFNATAARAEGRRLTKGYRKQAKSVRKRRRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC62</accession>
    <name>A0A132PC62_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858764.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02185"/>
    <dbReference type="EnsemblBacteria" id="KWX19908">
        <property type="protein sequence ID" value="KWX19908"/>
        <property type="gene ID" value="AFM11_33565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5046"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="11"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="338" mass="34406" checksum="DB68F3AED19E8E14" modified="2016-06-08" version="1">MSGFDLRGLARPVIVAPMAGGPSTPELAAAGSNAGGLGFIAAGYLTADALADRISAARGLTSEPLGVNLFAPQPSAGTPDGIEAYARALAGESDRYGVALGEPRYDDDSWSAKLEVVGDLRPEVVSFTFGLPTAEEISRLRAAGITTVGTVTTPDEARLAVDRGVDALAVQGPAAGGHRGTFDPAAPPATQPLDQLLAEVLAAVDVPVAAAGGLVTAADVAGVVAAGAVAAQLGTAFLLADEAGSSPVHRAALQSAEFTETVVTRAFSGRYARGLRNRFVIEHEEQAPFGYPEIHYLTSPVRKASVAAGDPQATNVWAGTGWRNIRTGSVKDIIGALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCD6</accession>
    <name>A0A132PCD6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_32775</name>
        <name evidence="9" type="ORF">AWC31_32150</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858294.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32150"/>
    <dbReference type="EnsemblBacteria" id="KWX19988">
        <property type="protein sequence ID" value="KWX19988"/>
        <property type="gene ID" value="AFM11_32775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12606">
        <property type="protein sequence ID" value="ORX12606"/>
        <property type="gene ID" value="AWC31_32150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4884"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="128"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX19988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX12606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="200" mass="22493" checksum="3FC530A72CC225E1" modified="2016-06-08" version="1">MHTECEPRTADPSGATDFVEAILPCIDQIERGARRLTPNKYDAEDLVQETLLKAYSGFHTFRQGSNVRAWLFRIMYNTWVSRYRARQRGPNEQLCEDFTDGQLSAEAGHTAAGLRSAEVEALEALRDDEIADALAAIPAANRMVVYYADVEGYQYREIASLMGTPVGTVMSRLNRGRRRLRELLADVAYERGMARHSATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCM4</accession>
    <name>A0A132PCM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_32485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858112.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20080">
        <property type="protein sequence ID" value="KWX20080"/>
        <property type="gene ID" value="AFM11_32485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4825"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="441" mass="46763" checksum="41593183B53FB8D8" modified="2016-06-08" version="1">MTVAGNEAAVRKAITGASIGNAVEWFDFAIYGFLATYIAANFFPAGNETAALLNTFAIFAAAFFMRPLGGFVFGPLGDRLGRQRVLAVVILLMSAATLGIGLLPTYATIGVAAPLLLLLLRCLQGFSAGGEYGGGAVYLAEYATERRRGLTVTFIAWSGVLGFLLGSITVTLLAASLSPEAMDSYGWRIPFLIAAPLGLVGLYIRLRLDDTPEFTKLDKSDRVAKSPLREAVRTARKPILQVIGMFIVFNVGYYVVFTFVPTYFIKSLQFSKTESFVSITLASLTALILILPLAALSDRIGRKPLLIAGSVGFMVFAYPLFLLMNSGSVVAAIVGHCLLAAIESVYVATAVTAGVELFATRVRYSGFSIGYNIAVAAFGGTTPYVVTWLTAATGNHLAPALYLIAAAIVSVATVFTLRESAARPLPGVEPAADEQRATMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCN0</accession>
    <name>A0A132PCN0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32550</name>
        <name evidence="3" type="ORF">AWC31_19685</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX17047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858138.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19685"/>
    <dbReference type="EnsemblBacteria" id="KWX20088">
        <property type="protein sequence ID" value="KWX20088"/>
        <property type="gene ID" value="AFM11_32550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17047">
        <property type="protein sequence ID" value="ORX17047"/>
        <property type="gene ID" value="AWC31_19685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4838"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="257" mass="27440" checksum="5E440CC5FDD7F74C" modified="2016-06-08" version="1">MRLTVLGCSGSVVGPDSPASGYLVTAPDTIPMVIDFGGGVLGALQRYADPNSVNVLLSHLHADHCLDLPGLFVWRRYHPMPATERGLMYGPAHTWSRLGAASSPEGNEIDDFSDIFEVRHWEDGKTVELGTLSVTPRLVCHPTESYGMRFTDPSGATLVYSGDTGYCDALVDLARGADLFLCEASWTHDPSRPPKLHLSGTEAGRAAAAAGVGELLLTHIPPWTSREDVISEAKAEFDGPVHAVVCGEVFDVTRGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCR7</accession>
    <name>A0A132PCR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_32960</name>
        <name evidence="10" type="ORF">AWC31_32405</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the extradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858380.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32405"/>
    <dbReference type="EnsemblBacteria" id="KWX20017">
        <property type="protein sequence ID" value="KWX20017"/>
        <property type="gene ID" value="AFM11_32960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12650">
        <property type="protein sequence ID" value="ORX12650"/>
        <property type="gene ID" value="AWC31_32405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4922"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="15"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX12650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="199" mass="21637" checksum="8DFF8586B09514ED" modified="2016-06-08" version="1">MIKPNNPNSEFEFGGINHVALVCSDMERTVDFYSNVLGMPLIKSLDLPGGIGQHFFFDAGNGDCIAFFWFRDAPDGVPGISAPAAIPGIGEIVSATGSLNHLALHVPAEKFDEYRQKLKAKGVRVGPVLNHDNSEMQVSPTVHPGVYVRSFYFFDPDGITLEFACWTKEFTEDDVHVAPKTSADRTPPADQPGLVASTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDD6</accession>
    <name>A0A132PDD6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_32740</name>
        <name evidence="5" type="ORF">AWC31_32115</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858278.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32115"/>
    <dbReference type="EnsemblBacteria" id="KWX19982">
        <property type="protein sequence ID" value="KWX19982"/>
        <property type="gene ID" value="AFM11_32740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12602">
        <property type="protein sequence ID" value="ORX12602"/>
        <property type="gene ID" value="AWC31_32115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4877"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX12602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="67" mass="7162" checksum="A287F3D50C19853A" modified="2016-06-08" version="1">MTQGTVKWFNGEKGFGFIAPDGGAPDVFVHYSEISGNGFRSLEENQRVEFEVTQGAKGPQAVGVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDQ5</accession>
    <name>A0A132PDQ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_30250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856818.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20460">
        <property type="protein sequence ID" value="KWX20460"/>
        <property type="gene ID" value="AFM11_30250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3947"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="14">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="203"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="13">
        <location>
            <begin position="345"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="425"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX20460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="463" mass="51591" checksum="3A41ADB551B49F48" modified="2016-06-08" version="1">MPRFEIPEGWCVQAFRFTLDPTAEQAHALARHFGARRMAYNWTVAQLKADIQAWRETGVETAKPSLRALRKRWNSVKNEVCVNAETGAVWWPECSKEAYADGIDGAVDAYWNWQQSRAGTRAGKRVGFPRFKKKGRDADRVSFTTGAMRVESDRRHLTLPVIGCVRTHENTRRIERLIAKGRARVLAITVRRNGTRLDASVRVLVQRPQQPNVELPESRVGVDVGVRRLATVATADGTVLEQVPNPRPLEAALTELRHASRVRSRCAKGSRRYRERTAEISRLHRRVNDVRTHHLHCLTTRLAKTHGRIVVEGLDATGMLRQKGLSGARARRRGLSDSALGTPRRHLSYKTGWYGSALVVADRWFPSSKTCHLCGHVQDIGWDEKWICDPTDGGCGVTHHRDDCAAINLARYEEPVSVVGPVGAAVKRGADRKTRPGRAGGDEARKGAGHPAGEQPRDGVRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDV5</accession>
    <name>A0A132PDV5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20519">
        <property type="protein sequence ID" value="KWX20519"/>
        <property type="gene ID" value="AFM11_30060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3906"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="119" mass="13396" checksum="7D3C467426D76E3F" modified="2016-06-08" version="1">MPTKRWFSQQLWTRVPSPVRHNPGEFRIYAADDDILDVDTGDTHTAAHDVWWRDHLADIDAEAAITRAIAAIRSAEDDLDEAVLRARRAQLSWAKIAAAAGMSPQSAHERWAKRASEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEQ4</accession>
    <name>A0A132PEQ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_28805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856284.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33035"/>
    <dbReference type="EnsemblBacteria" id="KWX20828">
        <property type="protein sequence ID" value="KWX20828"/>
        <property type="gene ID" value="AFM11_28805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3639"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="321" mass="34973" checksum="42E44D020F46D369" modified="2016-06-08" version="1">MSETTSRVLQLLGLLQSRRVWTGEELAERLGVTGRSVRRDIERLRDLGYPVYASKGHGGGYQLGAGAALPPLLLDPDEAVAMAVCLRLAAGGSVAGVGESALRALSKLDQVMPARLRSQVSAVHDATVTLAPTSSDSPVDPDVLMTLARACRDREHVSAGYTDIRGNNTQRRLEPYQLVTTGRRWYLMAYDRDRADWRSLRLDRMSDVRAMGSTFTARDAPDAASYVRRSISASPYRYVARVRYHAPQDVVAQKFSAASVTVEADGPDACILTAGADDPERMVLYFATVGHDFEVLEPPEVAAAVRDVSARLLRARQATSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PET7</accession>
    <name>A0A132PET7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856333.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20846">
        <property type="protein sequence ID" value="KWX20846"/>
        <property type="gene ID" value="AFM11_28430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3564"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FA_desaturase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="368" mass="41829" checksum="3662E6C294AC7686" modified="2016-06-08" version="1">MAISDIAAYAQLSQADIDAFGAELDTIRSDIEESLGERDAAYIRRTILFQRALDVAARLLIAGSRSKAGWLTGTAALAYAKSVENMEIGHNVCHGQWDWMNDPEIHSTTWEWDMVGPSEQWRYSHNYHHHVFSNVLGVDDDLGFGILRMTRDQEWEPQHLIQPVRNVLLAMVFEWGIALHDFYSARERAGTEAGKKAAGQVLRAKIGRQLAKDYVILPALSGRRWRHTLLANFTANLVRNLWAYVVIFCGHFPDGAEKFTPETLKQESRAEWYLRQMLGAANFKAGPVLAFSSGNLCYQIEHHLFPDLPSNRLPEISVRVRELCEKYNVPYTSGPLTRQYLQTLRTIFQLALPDTGWRTVLRAATSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFC7</accession>
    <name>A0A132PFC7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855284.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06925"/>
    <dbReference type="EnsemblBacteria" id="KWX21046">
        <property type="protein sequence ID" value="KWX21046"/>
        <property type="gene ID" value="AFM11_27080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3290"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014636">
        <property type="entry name" value="RNaseH/PGlycerate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036922">
        <property type="entry name" value="RNaseH_PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="364" mass="38846" checksum="0504FC1348ED5C46" modified="2016-06-08" version="1">MKVLVEADGGSRGNPGPAGYGAVVYTADHATVLAERKEAIGRATNNVAEYRGLIAGLEAATAQGATEVAVSMDSKLVVEQMTGRWRVKHPDLIDLQRQAAALAGTFDHVSYSWIPRARNSYADRLANEAMDAAAGIVDEAAPTKKPAEDEKPSAPGWTGAVGAPTRLLLLRHGQTELSVQRRYSGRGNPALTEEGRRQADAAARYLGERGGVAAVVTSPLQRAYDTAAAAAKALGLDVTVDDDLIETDFGAWEGLTFAEAAQRDPELHRRWLRDTSVEPPGGESFDAVAHRVRRARNRIIAEHGAATVLVVSHVTPIKTVLRLALDAGEGILYRLHLDLASLSIAEFYADGAASVRLVNQTAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFI3</accession>
    <name>A0A132PFI3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_27345</name>
        <name evidence="7" type="ORF">AWC31_07280</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855419.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07280"/>
    <dbReference type="EnsemblBacteria" id="KWX21090">
        <property type="protein sequence ID" value="KWX21090"/>
        <property type="gene ID" value="AFM11_27345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09988">
        <property type="protein sequence ID" value="ORX09988"/>
        <property type="gene ID" value="AWC31_07280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3343"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453281" evidence="4">
        <location>
            <begin position="38"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="268"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX09988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="382" mass="39478" checksum="A9706B50FF8A9D1C" modified="2016-06-08" version="1">MRHDRAHRPTSRVKRPLAGAIAVLTLLSGFLAGSVQADPAEDALAKLNELSRQAEQTTEAMHSAQLDLNEKLAAQQAAEKKHADDLAAADQAKAQLATFQASVNKVAAAQYMGGRTSGVDAILTADSPQQLIEQLAVQRVMATQMSAQMQNFRSIGEKAAAAEQASAKSAADAKTAAEQAAAVRADLQSKQSQLQVQIAVVKSQYQALTPVQREALAAVPPAPAAPPAPAPGALPPANDPGVLAAPPNGIPPGDIAPPEAAIPGGAPSGHSSTVIQAALSRIGSPYSWGGSGPSAFDCSGLVMWSFQQAGISLPHSSQALARGGQPVSQDQMQPGDLVTYYSDASHVGIYIGDGMMVHASTYGTPVRVAPVNNAPIYNVRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFQ3</accession>
    <name>A0A132PFQ3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein AFM11_28715</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28715</name>
        <name evidence="4" type="ORF">AWC31_32945</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856235.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32945"/>
    <dbReference type="EnsemblBacteria" id="KWX20812">
        <property type="protein sequence ID" value="KWX20812"/>
        <property type="gene ID" value="AFM11_28715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11506">
        <property type="protein sequence ID" value="ORX11506"/>
        <property type="gene ID" value="AWC31_32945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3622"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="158" mass="17421" checksum="CEF4723C5F3EE88C" modified="2016-06-08" version="1">MGLSSNIVGMHYRYPEYYEVGREKIREHAVAVKNDDAYYFDEAAAAELGHESLPAPLTFICIFGYTAQSAFFENANIAIQDAQIVQVDQELKFLKPIKAGDRLYCDVYVHSVRKAHGTDIIVTKNIITDDAGDVVQESYTTLAGRSGDGEEGFTDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFZ9</accession>
    <name>A0A132PFZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10405"/>
    <dbReference type="EnsemblBacteria" id="KWX20912">
        <property type="protein sequence ID" value="KWX20912"/>
        <property type="gene ID" value="AFM11_27885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3451"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="341"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="426"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="526" mass="56587" checksum="459F4C162B3A268B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG06</accession>
    <name>A0A132PG06_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MCE-family protein MCE1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21261">
        <property type="protein sequence ID" value="KWX21261"/>
        <property type="gene ID" value="AFM11_26160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="109"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="21313" checksum="55C628120006F418" modified="2016-06-08" version="1" fragment="single">MVIVIVAVLALTWMQFRGVFEPKTQLTVMSGRSGLSMDPGSKVTFNGVPIGRLSAVNVVESDGDTQAKLTVDVDPRYLNLIPENVHAELRATTVFGNKYISFVSPENPSPARVSAATPIRAQGVTTEFNTLFETITAISEQVDPIKLNETLTATAQALDGLGDKFGRSIVDGNDILADVNPRMPQIRRDITGLADLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG57</accession>
    <name>A0A132PG57_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25630</name>
        <name evidence="2" type="ORF">AWC31_36265</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854448.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36265"/>
    <dbReference type="EnsemblBacteria" id="KWX21310">
        <property type="protein sequence ID" value="KWX21310"/>
        <property type="gene ID" value="AFM11_25630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12064">
        <property type="protein sequence ID" value="ORX12064"/>
        <property type="gene ID" value="AWC31_36265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2989"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021456">
        <property type="entry name" value="DUF3107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11305">
        <property type="entry name" value="DUF3107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX12064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="83" mass="8692" checksum="7861B9DFBF58F11B" modified="2016-06-08" version="1">MEVKIGVTDSPRELTFNSAQTPSEVEQLVTDALGQGSGVLALTDEKGRRFLVQTARIAYVEIGAADVRRVGFGIGSEPAGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGP9</accession>
    <name>A0A132PGP9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_25155</name>
        <name evidence="11" type="ORF">AWC31_27475</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854182.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27475"/>
    <dbReference type="EnsemblBacteria" id="KWX21501">
        <property type="protein sequence ID" value="KWX21501"/>
        <property type="gene ID" value="AFM11_25155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14890">
        <property type="protein sequence ID" value="ORX14890"/>
        <property type="gene ID" value="AWC31_27475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2392"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="19"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX14890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="449" mass="46807" checksum="28ED0E58C7760EC4" modified="2016-06-08" version="1">MVLALPDESFAAFDSGDTAWVLASAALVLLMTPALAFFYGGLSRQKSVLNMMMMSFGALGVVSVIYVLWGYSMSFASAHTKESDILGIFDNPFSLFGVSQLLETREIGGEELHVIGGFGSVPAIVWVAFQLTFAVITVALISGALAERVKFGTWLVFSGVWVTLVYFPLAHMVWGGGLLSNNERGFASWLFGTTVGDDGTATATVAPIDFAGGTVVHINAGMAALVLAILVGRRRGFGKTAFRPHNIPWVMLGAALLWFGWFGFNVGSEGAADAVAGLVWVNTTAATAAAMLGWLLVERIRDGHPTSVGAASGIVAGLVAITPACGALSPVGSLFLGAIAGALSALAIGLKYKFGYDDSLDVVGVHLVAGLWGTVAIGLFATETGLFYGGGIQQLVVQIVIAVVATAFTAVMTAIIALALKPLGWRVTDEDEATGIDETEHAETAYELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGQ3</accession>
    <name>A0A132PGQ3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854194.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27505"/>
    <dbReference type="EnsemblBacteria" id="KWX21506">
        <property type="protein sequence ID" value="KWX21506"/>
        <property type="gene ID" value="AFM11_25185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2398"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="45"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="356" mass="37679" checksum="6FFEC440C00AAA8E" modified="2016-06-08" version="1">MLHVRGRGLPDGEPVEWWVAHGLLSAEPIANAETVFGADGDGGWIIPGLVDAHCHVGLGPGGPVSTDEAVVQAETERDAGALLLRDAGSPVDTRSFDDRDDLPRIIRAGRHLARPKRYMPGLPIDIEDESQLPEAVAEQARWGDGWVKLVGDWIDRGIGDLAPLWSDDVLKAAIDAAHAEGARVTAHVFGEDALPGLINAGIDCIEHGTGITDDIIELMLAQGTALVPTLINIENFPGIADKAAKYPTYAKHMRDLYASCHQRVGAAHEAGVPIFAGTDAGGMIAHGRIGDEIKALGKVGLSPTDALGAACWDARAWLGRPALEHGASADLLCFADDPRVVGVDHPDLVILRGRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGX6</accession>
    <name>A0A132PGX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854354.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27635"/>
    <dbReference type="EnsemblBacteria" id="KWX21563">
        <property type="protein sequence ID" value="KWX21563"/>
        <property type="gene ID" value="AFM11_25315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2425"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="332" mass="35969" checksum="000AC66EE1ACFD2A" modified="2016-06-08" version="1">MVLSKGVGLFPTEPVGTMCEYVRLSESLGYDNVWFGDSQNIWRESSTVMGAAAVGTERIIFGTGVTNAVTRHQSLLASTWATLAEFTGGRVALGIGTGDSSLRTMGLKPQKLAELEQSIQELRTLFKGEKVVEPTSGAEYHLNYLTEPMDIPIYIAASAPKILRMSGRIADGVIVLVGTAPHFIEAALKTIEAGAAESGRTLDDIHIVLWTPTAIDDDRTTARDLVRAHVSRVAIRPLPAKVEPSLEKAIDRIRDSYDYYQHMNTEASHADLVPDELVDLFALAGTPDECGQRLKEIEALGVDQVSIVPFVRPGESRAPTIRTFAEIVGGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH15</accession>
    <name>A0A132PH15_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853541.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24150"/>
    <dbReference type="EnsemblBacteria" id="KWX21603">
        <property type="protein sequence ID" value="KWX21603"/>
        <property type="gene ID" value="AFM11_24005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2160"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="24633" checksum="A0D5472B92F95EE6" modified="2016-06-08" version="1">MTTAYTQDREPADTMIVVDGVYAPQEDSQLLVDVMEKTGLAVARSVADLCTGSGVVAVNAAKQGASSVMAFDICPRAVRCARANAATSSAAVEVHRGSWARAAEFGPFDLVVCNPPYVPHDPDSEALPAAIGPARAWDAGYDGRMVLDPLCEAVPDLLADGGSLLLVQSEFADPRKTLAMLSAAGLDADVVAWQWIPFGPVLSARAEWLEETGRLEPGRREEELLVIRADKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH91</accession>
    <name>A0A132PH91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853644.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23895"/>
    <dbReference type="EnsemblBacteria" id="KWX21634">
        <property type="protein sequence ID" value="KWX21634"/>
        <property type="gene ID" value="AFM11_24220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2203"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="144" mass="16458" checksum="FD6EEFDAACA89841" modified="2016-06-08" version="1">MTHTEREEQAVAVVRRNTEEVQGKGNFELFEELFADDFVDHTPQPGTTPDKDGVRVLYRRLREAFPDFRPEIHWQTVDGDLVTTYKTYHGTHHGDFLGIAPTGRPVQFETVDAMRVRDGRIVEHWGVANLFSVVGQLGARIEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHD6</accession>
    <name>A0A132PHD6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853918.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23755"/>
    <dbReference type="EnsemblBacteria" id="KWX21731">
        <property type="protein sequence ID" value="KWX21731"/>
        <property type="gene ID" value="AFM11_24360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2232"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="24637" checksum="DAEFC19A6AB4957A" modified="2016-06-08" version="1">MTEFVIAPPPQASLPVSTGPERFPIRRVFCVGRNYAAHAREMGKDPDREPPFFFMKPADAVIDAAGTVPYPSLTSSFHHEIELVVALGAGGRDVAPADALNLVWGYGVGVDLTRRDLQDEAKKLSRPWDWSKGFDASAPCTPIHPVDAVGHPDSGEIWLRVNGDLKQQGDLKDLIWSVPEVISAISAAVDLAPGDLIFSGTPAGVGAMQPGDVVSGGVAGVAEFEFTIGQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHI9</accession>
    <name>A0A132PHI9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isoniazid-inducible protein iniC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853185.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28155"/>
    <dbReference type="EnsemblBacteria" id="KWX21805">
        <property type="protein sequence ID" value="KWX21805"/>
        <property type="gene ID" value="AFM11_23430"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2041"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin_N" evidence="1">
        <location>
            <begin position="47"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="496" mass="53606" checksum="38F172BDDF78297F" modified="2016-06-08" version="1">MSTGDQVRAILGGTIKAYRGDPAYRNRPDVHNELDRIGRRLNQPIRIALAGTLKAGKSTLVNALVGEDIAPTDATEATRIVTWFRHGPTPKVTANHRGGRRSNVPIARDPHDRGLTFSFAGLDPVDVVDLDVEWPAAELIDTTIIDTPGTSSLSRDVSERTHRLLVPEDGVPRVDAVVFLLRTLNAADIALLKQIGELVGGSAGALGVIGVASRADEIGAGRIDAMMSAKDVAKRFTAEMDKTGICQAVVPVSGLLALTARTLRQSEFVALEKLAGVDAGELAKAMLSVDRFVREDSSLPVDAATRAALLDRFGMFGIRISIAVLRAGVSDSVALADELLDRSGLIALRDVIDQQFAQRSELLKAHTALLSLRQFVQHNPIYATPYILADIDPLLADTHAFEELRLLSQLRSRPTTLNEDEMASLRRIIGGSGTDAASRLGLQPDTPYDGPRAAFAAAQRWRRRAEHPLNDPFTTRACRAAVRSAEALVAEYSTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHL3</accession>
    <name>A0A132PHL3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_23410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853173.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28135"/>
    <dbReference type="EnsemblBacteria" id="KWX21801">
        <property type="protein sequence ID" value="KWX21801"/>
        <property type="gene ID" value="AFM11_23410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2037"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="598" mass="59814" checksum="8A988251D925A854" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHM2</accession>
    <name>A0A132PHM2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853179.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28145"/>
    <dbReference type="EnsemblBacteria" id="KWX21803">
        <property type="protein sequence ID" value="KWX21803"/>
        <property type="gene ID" value="AFM11_23420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2039"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453041" evidence="2">
        <location>
            <begin position="20"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="364" mass="35820" checksum="C38C2B9D28F263FF" modified="2016-06-08" version="1">MAISLIDFILDLFRSPASAASFIADPDGSLRDAGLPNVTAAQLHAVAATAAPAGVLLGGGNPVLGLQRAVADHHNIPAQFAAPIASPFSPQTQFAPDVASHNNTDFASHNDVPIMSPNQDAGANAQQGAFNLGFGDITLGDKTTNTATNGGVVVGGDNDGDIVSGDGAVLGDGNTMNNGDILAGSGSNVVVGKDNEVEDNSQTAGGDLISDNEGPVISDVDMSGGHGGGASGGDSLIGIGSGNASGGDGGNAGSIIIADNDTNAVGGNQTSVGGDYGSDNTQDNSVNTAVETNTSTSWEDNSSSYESNIGSGNDTAFASGNDIASGNETAFASGNETNTALASGNSYETDTDVASNNNTGFDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHP2</accession>
    <name>A0A132PHP2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_23545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853238.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28270"/>
    <dbReference type="EnsemblBacteria" id="KWX21823">
        <property type="protein sequence ID" value="KWX21823"/>
        <property type="gene ID" value="AFM11_23545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2064"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="129"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="394" mass="42708" checksum="95088195714B1851" modified="2016-06-08" version="1">MTATLDHTIGLPDAEYRALRDQIFDAIWSELDPLEQRIEDEERVPNEIVLPILERVGAFGLLVPREYGGSGLSIAQYLPIIAEFAKIQGGLRVIVHVHNSFAHALSEIGNDEQKSAVLFGAATGRHSVAFALTEPLHGTGADLGTTAVRSGDEYMINGEKWLITNSDIASHFIVFAKTDATEVSAFLVPRDTEGLSIQPLPETMGCKGGEHGHITLSSVRVPATALIGAEGEGGQHLERALEISRVFIAASSLGTSERALELSIAHAKERVTFGKPIGTRQAVQRYLAEMATDVYALRGLLADAAQKWDSGRRIPAEASMCKLFGLEAVGRVTDRALLIHGGIGYTRAHPIERLYRDARLNWLEEGTPTIQYLVTAGQLLEGYSFADAFDAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHW1</accession>
    <name>A0A132PHW1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_22420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08790"/>
    <dbReference type="EnsemblBacteria" id="KWX21926">
        <property type="protein sequence ID" value="KWX21926"/>
        <property type="gene ID" value="AFM11_22420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1834"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="120"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="303" mass="32638" checksum="5D1B21BC46D47A2F" modified="2016-06-08" version="1">MNGESFDERSGRVGEIEELPQGRPVQPRGLPGPLGWLQRTNHSPAVIDMVRRVRRALPGDPDFGDPLSAAGDGGPRAAARVADRLLDRGAASREVSLGALQVWQAITERVSGVPPNPEVTLVFTDLVGFSTWSLKVGDDATLRLLRRVAQVVEPPLLESGGHIVKRMGDGMMAVFSDPGTALRAVLTALDALTDVDVDGYTPRMRVGMHTGRPQRLGSDWLGIDVNITARVMERAPKGGLVVSHTTLEGISEEQLAALGVTVKRERRPMFSARPEGVPEDLVMYRVRTARQRPGGDDNGAPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI32</accession>
    <name>A0A132PI32_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22830</name>
        <name evidence="3" type="ORF">AWC31_08370</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852857.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08370"/>
    <dbReference type="EnsemblBacteria" id="KWX21995">
        <property type="protein sequence ID" value="KWX21995"/>
        <property type="gene ID" value="AFM11_22830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10174">
        <property type="protein sequence ID" value="ORX10174"/>
        <property type="gene ID" value="AWC31_08370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1919"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CHK" evidence="1">
        <location>
            <begin position="114"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="354" mass="38206" checksum="1B39B9063926942B" modified="2016-06-08" version="1">MTAAVSIPSRPAEVTSSWLSTVLGVEVSSVATAPIGTGQTGATYRVSVTYPGPTDLPATFAIKLPSQDDTVRDRVVIGYRSEHAFYTNVADHVQIPVPHCHHCEIAGEGADFVLLLADMAPAVQGDQIAGCTRDEAALAVRALADLHGPTWCDARWANFPGIAMPKPEPDSAKGFGDVAKMAADITLDKLGDRMSAENRETLGAAMSVVTPWLLAEPDRFAVLHGDYRLDNMLFDPDRTRISVVDWQTLGSGLPARDLAYFTATSLLPETRAAAEADLVDEYHRTLCRHGVTGYDRETCWRDYRLGMLQAPLITVLGCAFATSTERGDDMMVVMAERGCQAIRELGTLDLIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIE2</accession>
    <name>A0A132PIE2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852333.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04270"/>
    <dbReference type="EnsemblBacteria" id="KWX22081">
        <property type="protein sequence ID" value="KWX22081"/>
        <property type="gene ID" value="AFM11_21455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1639"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="391" mass="41769" checksum="D2F6ED79DFDD38E2" modified="2016-06-08" version="1">MAGPMEGFRVVELGVWVAAPAAGGILADWGADVIKVEPPAGDPARTFGRMLGLDTDVNPPFEMDNRAKRSIVVDLTTDDGRATMAELLSGADVFLTNVRPAALSRLGLDFATVAARNPRLVYGLITGYGLSGPDADRAAYDVAAFWARAGLADLLTRPGDTPPFQRGGMGDHAAGMTLAAAVCAALLARTRTGTGQLVSTSLYRQGAYTVSFDLNTLLMTGQQIAIGRRETMANPCMNNYAAGDGRRFWIVGLQGDRHWPALCRVVGRTEWLADARFATARDRFANSRELIAELDELFVARPLAQWAELFDAEPDFFWSPVNSLDDVVADEQFHAAGGIVYVPDADSTMPMVATPADFSATPAEPRRAAPALGEHTEEILAELRGVRGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIF6</accession>
    <name>A0A132PIF6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_21835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852452.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04640"/>
    <dbReference type="EnsemblBacteria" id="KWX22139">
        <property type="protein sequence ID" value="KWX22139"/>
        <property type="gene ID" value="AFM11_21835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1715"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="280" mass="29265" checksum="B9C06BA5B5AB8DCC" modified="2016-06-08" version="1">MKGADVVVEDRVKLGDLQTMKRAGRKIVGVVAWDYQMARVVDRAGVDLVSVGDTVGANLWGQPNPLEITMDEMLVVCRAVRRGVRHALLSCDFPFGPVQEGTKSAVRAAIRFVKDAGVDMVKLDAAAEHLDAVEAVTRAGIPVFAQFGITPQTSLKYGVSYSATPGAGDTVPDELLDEMVGEAKRLEGAGAVLLNFTNSGPVVGPAVAQSVSIPVVGGFGGGPWLDGRVRMATAAIGYSADGLDNPPDTYANVAQLAFDAIAAYANDVRSARQIVGGIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIH7</accession>
    <name>A0A132PIH7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mycothione reductase</fullName>
            <ecNumber evidence="12">1.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_21875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="12"/>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852467.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04680"/>
    <dbReference type="EnsemblBacteria" id="KWX22146">
        <property type="protein sequence ID" value="KWX22146"/>
        <property type="gene ID" value="AFM11_21875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1723"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017817">
        <property type="entry name" value="Mycothione_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03452">
        <property type="entry name" value="mycothione_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="5"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="346"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="8">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX22146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="461" mass="50000" checksum="C77308605CD317E2" modified="2016-06-08" version="1">MEHYDLTIIGTGSGNSIIDDRYADKKVAICEQGTFGGTCLNVGCIPTKMFVYAAEVANTVAHSARFGIDSHIDKVRWPDIVSRVFGRIDPIAAGGEDYRRSASNITVYASHTRFGPKTDDGRYTLRTEAGDEFTSDQVVIAAGSRAFVPPNIVDCGCKYYTSDDVMRIPELPDHLVIVGGGFVAAEFAHVFSALGVHVTIVVRGAGLLTHCDETLCHKFSALAAEKWDLRTHENVVGSHQDGDRIVLELDDGKTLAADMLLVATGRVPNGDLLDAELAGVEVDEDGRVIVDEYQRTTARGIFALGDVSSDYQLKHVANHEARVVKENLLRDWDDTAALMRSDHRFVPSAVFTDPQMAMVGLTETQARAAGYDIVTKVQAYGDTAYGWAMEDTTGIAKLIGDRATGKILGAHIMGYQASSIIQPLIQAMSLGQTAREIARGQYWIHPALPEVIENALLGLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIL5</accession>
    <name>A0A132PIL5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852523.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04850"/>
    <dbReference type="EnsemblBacteria" id="KWX22176">
        <property type="protein sequence ID" value="KWX22176"/>
        <property type="gene ID" value="AFM11_22045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1757"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014923">
        <property type="entry name" value="DUF1802"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008307">
        <property type="entry name" value="UCP018957"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08819">
        <property type="entry name" value="DUF1802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018957">
        <property type="entry name" value="UCP018957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="187" mass="20424" checksum="5C0C6C94F6412138" modified="2016-06-08" version="1">MTALADTQTALKEWSAAVHALLDGRQTVLLRKGGIHEKRFEVNASRFVFFPTIAHSHAERVRPEHADLLAAAACDSTEDAVTIRAGAKVVGAVEVNRPDAVGELAGLHIWTAESVRADRLDFRPKHRLTVLVVQVSPLIAPVRLMRTPDYAGCRSWVELPVQAEWGTPVHDDATLADIAERVRTSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIS5</accession>
    <name>A0A132PIS5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein HslJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852574.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04945"/>
    <dbReference type="EnsemblBacteria" id="KWX22203">
        <property type="protein sequence ID" value="KWX22203"/>
        <property type="gene ID" value="AFM11_22185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1786"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453296" evidence="1">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="2">
        <location>
            <begin position="28"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="2">
        <location>
            <begin position="137"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="253" mass="26005" checksum="0F3BA5EBA443B28A" modified="2016-06-08" version="1">MRLLAIALAALALAGCSDTGNADDQNPNGRTFVSVEVEGNQIPGGGPLTVVFDSGQISTFAGCNHGSGPVDLSNGKVVTELASTMMACPPPLGDADAWMSQFFEAQPSWSLSGDTLTLKTDTATVTLRDKKVVHPDRSLTDTTWQVTSLVSGQSVSTSQALEQAKPTVKIAADGAVTGSTGCNQITGHAVVSGTPAIIEFGPLATTRMACPNGLGEVEQAVMRVLNGKVQTAIDSDELTLTGADGYGLVLRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIW3</accession>
    <name>A0A132PIW3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852426.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04570"/>
    <dbReference type="EnsemblBacteria" id="KWX22127">
        <property type="protein sequence ID" value="KWX22127"/>
        <property type="gene ID" value="AFM11_21765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1701"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="71"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="233"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="355" mass="39826" checksum="2167A348401D8067" modified="2016-06-08" version="1">MASRTTTKVTHYHVQKKRRADFIEEWRGYQKTVVALEDVTMAQTARGTRVGVYVGADGDRPTRSMDALAHEIDPGVVSTIHRHSWDAMVLVVAGQGWTEIDGERIDWGPGDSIHIPAWAWHRSGNDGDGTARYLTFSSEPLLETMGMSMIEDAGHTPVSELPGRPDFSAAVTGDDPYARRVRRLAADQHARRSGRLHTSWDELELLPTPRGTRTTFLLDRAIGYQASGISMAMFEIGPGRGQSMHRHAGEAWLYVLEGSGHSYLGTEPEGGTNYPWKKGDLIVVDHFLWHQHFNDDPQNTAKVVRIHMFDSLLDTMRVLMDPMVLFEEPPEHIRDAQAGDPTTVDWPEVTRPTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIZ4</accession>
    <name>A0A132PIZ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_20555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851993.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05970"/>
    <dbReference type="EnsemblBacteria" id="KWX22234">
        <property type="protein sequence ID" value="KWX22234"/>
        <property type="gene ID" value="AFM11_20555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1448"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01005">
        <property type="entry name" value="PBP2_CysP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="351" mass="36856" checksum="9BD2C42E36CBAE63" modified="2016-06-08" version="1">MPTKKLDINKFWRNVARNSAVLATTGVLVVGCGGGSSDVAGGDGGAGGAETTLTLVAYAVPEPGWSKIIPAFAATEEGKGVAVTTSYGASGDQSRAVVDGKPADIVNFSVEPDITRLVKAGKVAEDWNAGNTKGIPFGSVVSLVVRKGNPKGIKDWDDLLQPGLEVVTPSPLSSGSAKWNLLAPYAAKSNGGKDAEAGIDFVNKLVTEHVKTRPGSGREATDVFLQGTGDVLISYENEAINVERQGKPVEHINPPQTFKIENPVAVVNTSAHADAANALKNFLYTPEGQKLWAEAGFRPVDPAVAAEFTKDFPTPEKLWTIAELGGWSEVDPALFDKDNGTITKIYKQATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ13</accession>
    <name>A0A132PJ13_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein mbtH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20665</name>
        <name evidence="3" type="ORF">AWC31_06080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852036.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06080"/>
    <dbReference type="EnsemblBacteria" id="KWX22254">
        <property type="protein sequence ID" value="KWX22254"/>
        <property type="gene ID" value="AFM11_20665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09786">
        <property type="protein sequence ID" value="ORX09786"/>
        <property type="gene ID" value="AWC31_06080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1470"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="70" mass="7983" checksum="930E3C2D653D8765" modified="2016-06-08" version="1">MSSNPFDDENGTFYVLVNNEEQHSLWPAFADVPAGWRVVFGESTRADCLAYVEENWTDLRPKSLRDAMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJB0</accession>
    <name>A0A132PJB0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_20810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852083.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06225"/>
    <dbReference type="EnsemblBacteria" id="KWX22277">
        <property type="protein sequence ID" value="KWX22277"/>
        <property type="gene ID" value="AFM11_20810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1500"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="29"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="583" mass="61154" checksum="C37994E89185DE66" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJU1</accession>
    <name>A0A132PJU1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_20835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852092.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06250"/>
    <dbReference type="EnsemblBacteria" id="KWX22282">
        <property type="protein sequence ID" value="KWX22282"/>
        <property type="gene ID" value="AFM11_20835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1506"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="PTHR10909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="130"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="274"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="ACOX" evidence="6">
        <location>
            <begin position="493"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="640" mass="70388" checksum="0B8CFCC4BC10DC0E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJZ9</accession>
    <name>A0A132PJZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21220</name>
        <name evidence="2" type="ORF">AWC31_06585</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852226.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06585"/>
    <dbReference type="EnsemblBacteria" id="KWX22342">
        <property type="protein sequence ID" value="KWX22342"/>
        <property type="gene ID" value="AFM11_21220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09870">
        <property type="protein sequence ID" value="ORX09870"/>
        <property type="gene ID" value="AWC31_06585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1590"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX09870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="225" mass="24567" checksum="523F7614AFB63998" modified="2016-06-08" version="1">MTVVGVVCGLGPDGYLASHRNYIDAVVRAEGSPVLIPATLDPERALRLAERIDALLLLSGGDIHPRRYGETTRATLMGVDEQRDLVEIAILERAMRRGIKAFGVCRGAQLLAVAHGGRLHQDLPANGLRQHMADTVDGGYASIRHDVEIKEGSLAGELFPNLTEVNSQHHQAISDTGSLTATAWSPDGVVEAIEGEICFGVQWHPELIYTENPEHLKPFEWLVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK62</accession>
    <name>A0A132PK62_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_18895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851801.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_14985"/>
    <dbReference type="EnsemblBacteria" id="KWX22721">
        <property type="protein sequence ID" value="KWX22721"/>
        <property type="gene ID" value="AFM11_18895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1114"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="268" mass="27787" checksum="3E3D0CFD6D8E489B" modified="2016-06-08" version="1">MNFLQQALTFIFTAANWTGPAGLGIRIVEHLQYTVVAVLFSVLVAVPVGMLIGHTGRGTFLVVTGVNALRALPTLGVLLLGVLLWGLGLVPPTVALMLLGIPPLLAGTYAGIANVDRSVVDAARSMGMTESRVLLRVEVPNAMPLILGGLRTSTLQIVATATVAAYASLGGLGRYLIDGIKVRQFHIALVGALMVTALALILDAALAFAVWLSVPGTGRLRSWRTGGGRLPQPLLDDEIALESRSPARSGGSSGVGYEGGPPSHTVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKF4</accession>
    <name>A0A132PKF4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4157 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851196.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11985"/>
    <dbReference type="EnsemblBacteria" id="KWX22818">
        <property type="protein sequence ID" value="KWX22818"/>
        <property type="gene ID" value="AFM11_17915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.938"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="2">
        <location>
            <begin position="79"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="238" mass="25021" checksum="FE7BCBBAB00631C4" modified="2016-06-08" version="1">MRTHDSDHTHASELRPKASRLEEPESAMAMRAALSGRLDVAGPAGVAGLQRVAGNSGASALMDEDRSPVHNVIGSGGSPLPADLRTDMEGRFGHDFGDVRVHHDGAAHDSAKSVNAQAYTVGSDIVFQSGKYDPASDAGKHMIAHELTHVVQQRSGPVDGTDAGGGVKISDPSDRFEREAVANADRVMASPAPAAAPASAQRVAENAAVQRQEEPAEEEETAQTFVQRQDEEAEEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKL1</accession>
    <name>A0A132PKL1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851340.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12430"/>
    <dbReference type="EnsemblBacteria" id="KWX22881">
        <property type="protein sequence ID" value="KWX22881"/>
        <property type="gene ID" value="AFM11_18475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1029"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="63"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="31935" checksum="B539ECA27906AEB4" modified="2016-06-08" version="1">MTTPPFDYSPITERAPITWPNGARVAVYVGLNIEHFLIDHPSTSIWPGTADLKPDALNYGWRDYGARVGIWRTIESLDRHGVRPSVLLNSAVIKHHPQIVAAGLERDWAWLAHGRTNSILHTDLDVDEERRVLAEIAGDIADATGRQPRGWMGPGLTETHNTPKLLAELGFHYVLDWTNDDQPYPLTTPGMISVPYSVELNDLLIFGKGINGPEFEQMVIDQYEQLHADSATSGRVLALALHPFVIGQPFRHKYLDRVLKYLAAQSDAWLTTSDEIAAHVRPSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKM9</accession>
    <name>A0A132PKM9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851048.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04985"/>
    <dbReference type="EnsemblBacteria" id="KWX22747">
        <property type="protein sequence ID" value="KWX22747"/>
        <property type="gene ID" value="AFM11_17465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.848"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="245" mass="25876" checksum="4B8F4B70FC54AA8D" modified="2016-06-08" version="1">MPTIKDSISTPDGTCAVTFATPDGSGPWPGVVMYPDAGGARATFDEMAAQLASEGYAVLVPDVYYRDAGWAPFEMATVFKDEDERARLFSMISKVTPDIMAKDAAAFFDYLEQRPDVVDGKFGTTGYCMGGRTSLVVAGRVPERVAAAMSFHGGGLASDDPGSPHLLADKIQAAVYVGGAKDDASFTPEHAKTLESALSAAGVEHTIEMYDAAHGFAVPDNAPYDAAAAKQHWEAMESFFGARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKX7</accession>
    <name>A0A132PKX7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850700.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01215"/>
    <dbReference type="EnsemblBacteria" id="KWX23000">
        <property type="protein sequence ID" value="KWX23000"/>
        <property type="gene ID" value="AFM11_16645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.679"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453153" evidence="2">
        <location>
            <begin position="29"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="335" mass="32333" checksum="7B71AAEF87F7BCB0" modified="2016-06-08" version="1">MSSKKLFATVVAIGSSAALLFGSGVANADPAPLPIDGLQAPGLSAVEGLSPIIQQAAADPAGAAQLLMAAAQAFAANKEAPADSRNVATAVNQFVTEPAAAAPVALAPEHIPAAGAGLDAHLPAGVDPAHAVGPALHVPEAAPPAPAPEAAAPAPAPAPEAAPAPAPAPAPEAAPAPAPAPQGAAAPAPGPTPPPGFGPDTPPTQDFMYPSISNGCLKDGGNVLATAISVAGPAKIPAPGPGPGQTAYVFTAVGTPGPAAEQKLPLNVTWVNLTTGKSGSATLKPRSDINPQGPTTLTAIADTGSGSIMSTIFGQVTTTEKQCQFMPTIGSTVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL75</accession>
    <name>A0A132PL75_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22937">
        <property type="protein sequence ID" value="KWX22937"/>
        <property type="gene ID" value="AFM11_18285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1015"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="188" mass="21462" checksum="C5563F526CF69BE1" modified="2016-06-08" version="1">MGDWAPFHRLEQAAPPYLRDAEMALETVRGVVDLDTIQTFALDRYIKKHDWGRALYQEIVLTDGQLLIVWIGDDVLADDDDHNPGLPLLQSQIRAIPLSWIYDISIDTHYQTLDGQRSLYSVEVRLYLAVHDYAKRVRGTKRTEIYTEQLLLAKSVTDGGHDQMLRLIEFGRALANLVRPAAEARHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLG3</accession>
    <name>A0A132PLG3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850171.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15895"/>
    <dbReference type="EnsemblBacteria" id="KWX23188">
        <property type="protein sequence ID" value="KWX23188"/>
        <property type="gene ID" value="AFM11_15275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7168"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="194" mass="21320" checksum="FAAAF1768E996A2F" modified="2016-06-08" version="1">MDALTFLRQDHKSVLGMLEVLDGAPTGSGAEQSGLATMVTNLVIAESQHEAIEQQIFWPAVRDALDDGDELADEAIEQEQAGKELLQKLEDGQPGETEYHDALREFVKVGREHIAYEEDVVWPKFEAVVSREELEKLGTKLEQAKKIAPTRPHPDTPSNPAVQKTMGAAAAIVDHVRDAATGREKDNPPDPQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLI6</accession>
    <name>A0A132PLI6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850939.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23114">
        <property type="protein sequence ID" value="KWX23114"/>
        <property type="gene ID" value="AFM11_17300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.813"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="310"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="474" mass="52246" checksum="E727EDFEC4556E81" modified="2016-06-08" version="1">MFESFSDADLIDGMGETTRGESAQIARRLEIIGELDARRSVELAEMKLWRTDPFEAVAAEVSAALNISRARARTLIHYSRVLRDKLPKIAAVFAAGGIDFRLLGTLIARTDLVDPAVWPDLDEALACNAPKWMKLSEPKLKDRIDEWVATHDPNGVRVTPKVDEGRHVTIQPFSPGVATIWATVRADVAAAIDQRLDALVDTVCENDPRTRDQRRSDALGSIAHMHDQLACQCGQPDCPTAERRTGAGTAVIHVLAEQATIDGTSNAPGYLPGFGIQPAETVRELAKTATLKPLTVPGDTPEPGYRPSVALAEFVRWRDLTCRFPGCDAPAVRADIDHTAPYPAGPTHPSNTKLYCRSHHLLKTFHTGPNGWTDRQLPDGTIEFTAPTGHIYTTEPHGAALFPALARPTGELDIPETTAPDANRAIMMPTRKHTREHDRQTRIAAERRQRAELNAERQRQHQAWLADNYEPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLM4</accession>
    <name>A0A132PLM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_15635</name>
        <name evidence="5" type="ORF">AWC31_16130</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003882601.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16130"/>
    <dbReference type="EnsemblBacteria" id="KWX23250">
        <property type="protein sequence ID" value="KWX23250"/>
        <property type="gene ID" value="AFM11_15635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17937">
        <property type="protein sequence ID" value="ORX17937"/>
        <property type="gene ID" value="AWC31_16130"/>
    </dbReference>
    <dbReference type="GeneID" id="44296510"/>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7249"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX17937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="67" mass="7317" checksum="56DD66E09EF746EA" modified="2016-06-08" version="1">MPQGTVKWFNAEKGFGFIAPEDGSADVFVHYTEIQGSGFRTLEENQKVEFEVGQSPKGPQATGVRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLP5</accession>
    <name>A0A132PLP5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850340.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16020"/>
    <dbReference type="EnsemblBacteria" id="KWX23268">
        <property type="protein sequence ID" value="KWX23268"/>
        <property type="gene ID" value="AFM11_15745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7272"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="262" mass="27833" checksum="A038D1299A4189ED" modified="2016-06-08" version="1">MSSTPDGLRPDAAPAWLKPLVDNLDGVPRAYRRRVPPDVLATIVEANNQAAQAGARRDAAVLVLFSGPPDAPPGTLPDDADLLVTVRASTLRHHAGQAAFPGGATDPEDTGPVSTAFREATEETGIDTGRLYPLATLERMFIPPSGFHVVPVLAYSPDPGPVAVVDESETAVVARVPVRAFVNPENRLMVYRDANTSRFAGPAFLLNEMLVWGFTGQVISAILDVAGWAKPWNTDDVRELDAAMALVGHENGYGEAHRGTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLZ6</accession>
    <name>A0A132PLZ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15650</name>
        <name evidence="4" type="ORF">AWC31_16115</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16115"/>
    <dbReference type="EnsemblBacteria" id="KWX23375">
        <property type="protein sequence ID" value="KWX23375"/>
        <property type="gene ID" value="AFM11_15650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18153">
        <property type="protein sequence ID" value="ORX18153"/>
        <property type="gene ID" value="AWC31_16115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7253"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021202">
        <property type="entry name" value="Rv3654c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03816">
        <property type="entry name" value="tadE_like_DECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453390" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="106" mass="10358" checksum="311DD15C108A15D8" modified="2016-06-08" version="1">MLAVALIAILLAFTTGAAYLGAAVIARHRAQAAADLAALAAAGAVAGGPEAACARASQIASAMRTTVAACRVDGLDVVLDVQVRVSLGRFGTGSARAVARAGPVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM30</accession>
    <name>A0A132PM30_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the non-flavoprotein flavin reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850513.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16830"/>
    <dbReference type="EnsemblBacteria" id="KWX23353">
        <property type="protein sequence ID" value="KWX23353"/>
        <property type="gene ID" value="AFM11_16225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7370"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="16"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="189" mass="21005" checksum="5C15838C9EF5088E" modified="2016-06-08" version="1">MTQPEPIDPRTFRNVLGQFCTGITIITTVHDEVPVGFACQSFAALSLDPPLVLFCPTKQSRSWQAIEASGRFCVNILHEKQQHVSARFGSKEPDKFAGIDWEPSQLGSPVIDGALAHIDCKVDSVHDGGDHFVVFGAVHSLSEVPKRKPRPLLFYRGEYTGIEPDKNTPAQWRDDLEAFLTATTQDTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM94</accession>
    <name>A0A132PM94_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850117.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15755"/>
    <dbReference type="EnsemblBacteria" id="KWX23162">
        <property type="protein sequence ID" value="KWX23162"/>
        <property type="gene ID" value="AFM11_15135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7139"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="223" mass="23631" checksum="12C0F2E67D510B0C" modified="2016-06-08" version="1">MDSLVSIVVPALVAVLTAAGAVIGIQFRDVDAYERRRGVWQWLLVLLATVATMGATSSASGVGQLIEAGVMAVLAVAAIVLAHVMWRRRVPDAEPRTLAIATAAAISAVVVVLGSTAFAYISNKSCRQVEPLVGLSHQAFILPVFDTNRGPTAGDFGDWAKAVRDQAQQVSPGEVADQAGKLADLADQIADTARNNDKAKHAMLGTQYYEELKPILAKCHIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMI1</accession>
    <name>A0A132PMI1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_14905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849982.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17995"/>
    <dbReference type="EnsemblBacteria" id="KWX23550">
        <property type="protein sequence ID" value="KWX23550"/>
        <property type="gene ID" value="AFM11_14905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7092"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="249" mass="26749" checksum="BD63AC528AAADC6C" modified="2016-06-08" version="1">MPASETTPAAVSLAASDIHLAFGPNKVLRGVDLDVPAGTTTAVIGPSGSGKSTLLRTLNRLYEPDRGDILLDGRSVLADNPDQLRQRIGMVFQQFNLFPHRTVLDNVTLGPRKLKGLDAEAARQLGLAQLDRVGLRHKADVRPATLSGGQQQRVAIARALAMAPQVMFFDEATSALDPELVKGVLELMAELAADGMTIIAVTHEMGFARSTADSVVFMDHGKVVESGTPTQIFEAAETDRLRRFLSQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMU8</accession>
    <name>A0A132PMU8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Sigma-70 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12725</name>
        <name evidence="2" type="ORF">AWC31_03045</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849046.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03045"/>
    <dbReference type="EnsemblBacteria" id="KWX23661">
        <property type="protein sequence ID" value="KWX23661"/>
        <property type="gene ID" value="AFM11_12725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11123">
        <property type="protein sequence ID" value="ORX11123"/>
        <property type="gene ID" value="AWC31_03045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6635"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="71" mass="7942" checksum="88284E558B7243D0" modified="2016-06-08" version="1">MSEIDALITDGVSSSDPAVGLRAVRALQRLQERLEAIHVANAREQGWSWQAIADALEVSRQAVHQKHNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN50</accession>
    <name>A0A132PN50_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849609.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03645"/>
    <dbReference type="EnsemblBacteria" id="KWX23761">
        <property type="protein sequence ID" value="KWX23761"/>
        <property type="gene ID" value="AFM11_13360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6766"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014529">
        <property type="entry name" value="UCP026631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026631">
        <property type="entry name" value="UCP026631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="386"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="470" mass="50572" checksum="5E68ADC6975EA468" modified="2016-06-08" version="1">MLFVHPVHEVLQQIPLLVGSVVLGSATGNPLWTVAAIALTVAFGLARWFTTTYRIEPTEVQLRTGVLQRKVLSVPRNRIRSVSTDARLLHRALGLTVLRISTGQEAKGDAEFALDAVQAEQVPRLRAILLADAVPVADTPPGRVLARWQPAWLRYSPLSFTGLAMIAAAVGLVYQAGAGALLGNSELARSGLAFAERMGVFVSVTFIVLAVLVLSVVLSVLRSLVTYGNLALRRDSDVLHLQHGLLRVREHTYDMRRLRGGSLREPLLVRLFGGARLDAVMTGVGGEGEASLLLPPCPSATATTVLTDLIEQPDAVTGPLRTHGPAATRRRWTRALMWPALALVPLAVVRAPVWAWVLWAVVALTAALLAADRARSLGHRVDAGWLVARNGSLERRRDCLQTAGIIGWTVRQTLLQRRAGVATLIAATAAGDKHYQVIDVPAAQAWSIVAAASPWVADNQWADGVGSELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNQ9</accession>
    <name>A0A132PNQ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11185</name>
        <name evidence="4" type="ORF">AWC31_30715</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848088.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30715"/>
    <dbReference type="EnsemblBacteria" id="KWX23933">
        <property type="protein sequence ID" value="KWX23933"/>
        <property type="gene ID" value="AFM11_11185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12367">
        <property type="protein sequence ID" value="ORX12367"/>
        <property type="gene ID" value="AWC31_30715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6314"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX12367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="327" mass="35205" checksum="D0747AC0F9F570B5" modified="2016-06-08" version="1">MITLTATAPEPLSRTTASQRPPLRVGLVQHRWRPDADELAKVLREGIDRAAGAGATAVFLPEITLLRYPADTPAGPNPGDHAEDLTGGPTFALAAEAARANGIFVHASLYEKAPAADGLGYNTAILVSPSGELVGRTRKMHIPISAGYYEDTYFRPGPADDNPYPVYNPEGLGARLGMPTCWDEWFPEVARNYSLGGAEIVVYPTAIGSEPVFPAFDTQPLWQQVIVANGISSGLFMVVPNRTGDEGTVSFYGSSFISDPYGRVLVQAPRDEEAVLVADLDLDQRRDWLELFPFLLTRRPDSYGPLTAPVDPSRPYGAGHAATAVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNR9</accession>
    <name>A0A132PNR9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-isopropylmalate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848264.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23986">
        <property type="protein sequence ID" value="KWX23986"/>
        <property type="gene ID" value="AFM11_11490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6374"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="1">
        <location>
            <begin position="40"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="188" mass="19335" checksum="A76B9164AF66774A" modified="2016-06-08" version="1">MSADLAVTGRVWVFGDSLNTDAMYSPDAMKLDVSQAAKMVVYEVRPGWTDQVARGDIVVAGKNFGVGSSRPVAALFNQLGVAALIAEEFNSLFFRNAVNAGLPAMTVPGATAAFSDGDTGTFDLRSGTWHNDTTGVGGTVGKLPDLILDILASGGTLPRLAEQGYIPAELADTLRSPAVSAAAQGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNY9</accession>
    <name>A0A132PNY9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Uricase</fullName>
            <ecNumber evidence="5 7">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_11000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>H2O + O2 + urate = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 7"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848001.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31255"/>
    <dbReference type="EnsemblBacteria" id="KWX23907">
        <property type="protein sequence ID" value="KWX23907"/>
        <property type="gene ID" value="AFM11_11000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6276"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="PTHR42874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX23907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="299" mass="33601" checksum="D4BF047BBCDB339C" modified="2016-06-08" version="1">MSNIILGKNQYGKAENRVVRIYRDSPRHEIHDLNVSTCLRGDFSAAHLTGDQSRVLPTDTQKQTVYAYAKQPGISTIEDYGLALARHFVNDVEPVDAARIEIDEYAWQRVVVNGSEHDHTWVRRGQETRTAAVTVDGDGEWVIGGLKDLVILKSTGSEFAGFLTDEYTVLEPTHDRVMATSLIAQWRFTTTDVAWDELYDGVKARMTEQFAVVQSLALQQTLFHMGKAVLESYPEIAEVRLSAPNKHHFVYDLTPFGLQNNNEVFHADDRPYGLIQATVTRDDAPSPGPAWDLQQGWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNZ5</accession>
    <name>A0A132PNZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848381.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30320"/>
    <dbReference type="EnsemblBacteria" id="KWX24023">
        <property type="protein sequence ID" value="KWX24023"/>
        <property type="gene ID" value="AFM11_11705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6418"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="240"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="394" mass="43025" checksum="F94A2A5039374427" modified="2016-06-08" version="1">MPDGEFAGSPIDVFDGVGSAVPAELADHLRTVRLVDHHVHGTFDKPVDRAGFEASINEGSTDPIPDFMTQFDSPLGLSIRRWCAPVLGLPAHAGADEYWKRRSELSPDELSELMLPLAGVERWVVDTGFQGDLITTPERLTQLSGRPSSSILRLERLAEELLEDGTRPEDFPDAFRAALADAAASPDTVGTKTIAAYRTSFDIDWSRPADAQVVEHARELAGRDTLRLDSPVLIAFGVHEAAAHGLPIQVHVGFGDRDLDLHRTDPMLLLPLLRTITPVPVLLLHCYPFHRKAGYLAQAFDHVNFDVGLGINYLGVRSTGLVAEALETAPFAKQLYSSDAFGPPELHLLGSVLWRRAMGLVLGEWVRAGDCTEADAIRIVDMIGVHNANRVYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP12</accession>
    <name>A0A132PP12_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxysome structural protein EutM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848547.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09975"/>
    <dbReference type="EnsemblBacteria" id="KWX24078">
        <property type="protein sequence ID" value="KWX24078"/>
        <property type="gene ID" value="AFM11_12000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6479"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="93" mass="9353" checksum="F35B1B9E55195B09" modified="2016-06-08" version="1">MSSNAIGLIETKGYVAALAAADAMVKAANVTITDRQQVGDGLVAVIVTGEVGAVKAATEAGAETASQVGELVSVHVIPRPHNELGAHFSVSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP53</accession>
    <name>A0A132PP53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11875</name>
        <name evidence="2" type="ORF">AWC31_30175</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848473.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30175"/>
    <dbReference type="EnsemblBacteria" id="KWX24054">
        <property type="protein sequence ID" value="KWX24054"/>
        <property type="gene ID" value="AFM11_11875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12276">
        <property type="protein sequence ID" value="ORX12276"/>
        <property type="gene ID" value="AWC31_30175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6454"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX12276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="109" mass="12481" checksum="0EFBC4CD567FDCCE" modified="2016-06-08" version="1">MSAVLPTEFADLEPYSEWCLSTERQRYAKRLASSMTEMQAFYDAITARAEEAIAYCDKFPLDDLPDDVLALMHMLYSMITVSFPVECWKQPRVPDSGATWLDCDFEPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPB6</accession>
    <name>A0A132PPB6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848808.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24155">
        <property type="protein sequence ID" value="KWX24155"/>
        <property type="gene ID" value="AFM11_12455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6570"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="116"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="37278" checksum="A49CB094E465E5BC" modified="2016-06-08" version="1">MSIKGTLIKLGIFSLVLLTFTALIFVVFGQIRFNRTAEYSAIFKNVSGLRSGQFVRAAGVEVGKVSSVELINGGEEAEVKFSVEKSLPLFDQTTAAIRYQDLIGNRYLELKRGESNKIIPPGSTIPLERTEPALDLDALVGGFRPLFRSLDPEKVNTIAKSIITIFQGQGGTINDILDQTAQLTESIAERDQAIGEVIKNLNTVLDTTVKHQKQFDETLVNFETLITGLKDRADPIGASVANISNAAGSLADLLSDNRPLLKDTVGYLDVIQKPLVDQRQEVNDILVQIPAALKIIGRAGGIYGDFFNFYACDLTLKLNGLQPGGPVRTVRVTSQPSGRCTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPP6</accession>
    <name>A0A132PPP6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848865.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30240"/>
    <dbReference type="EnsemblBacteria" id="KWX24177">
        <property type="protein sequence ID" value="KWX24177"/>
        <property type="gene ID" value="AFM11_11805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6440"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="302" mass="33159" checksum="FDC29C67466DC20D" modified="2016-06-08" version="1">MQPNGRDRLRELLDAVVADDNAGVGEMARSSHASEFHFSREVRRLTGEPPAALRRRVMLERAAWRLRQGEGVAEVAAAEGWSSAEVFSRAFRRAFGVPPSRASAVGFRLAAPNGVHFHPPHSLWCDGRAGGSGPDIAQFMLVHDIADTGYLIEQAAALTETQWRQEISPGQVVLDWDGPEPSVAAVLGTIVWTKEVWLATIEGHDFPPRTTTAEATAEQLAAHHEAIGKRWTTVISEHAAAGRLADTVIDALCDPPESFQLYGIVAHVLNYSAHRRGLARAMLVRHGIDTHRGDPLEWMRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPQ7</accession>
    <name>A0A132PPQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847438.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18550"/>
    <dbReference type="EnsemblBacteria" id="KWX24320">
        <property type="protein sequence ID" value="KWX24320"/>
        <property type="gene ID" value="AFM11_10065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6049"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="12"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="512" mass="56541" checksum="7C4FBCB25B99957B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ37</accession>
    <name>A0A132PQ37_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847846.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19390"/>
    <dbReference type="EnsemblBacteria" id="KWX24451">
        <property type="protein sequence ID" value="KWX24451"/>
        <property type="gene ID" value="AFM11_10875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6214"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="28567" checksum="E508D1C533F901B6" modified="2016-06-08" version="1">MSNELAGKVAVITGGSAGLGEGLVRRFVAEGAAVLIGDVEKDRGAALVEELGGDTAFLPTDVSDPEQVTALVDAAVERFGGLHVMVNNAGISGTMHRRFLDDDLADFHRVMGVNVLGVMAGTRDAARHMAEHGGGSILNLTSIGGIQAGGGVMTYRASKAAVIQFTKCAAIELAHYEIRVNAIAPGNIRTAIVAKSASAEDRQRLEEFEEGIRAQMRNDRPLKREGTVEDVAEAALYFATDRSRYVTGTVLPIDGGTVAGKVLVRKEKPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQE2</accession>
    <name>A0A132PQE2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="6">1.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_07645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a menaquinone + succinate = a menaquinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:27834"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="6">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846053.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22140"/>
    <dbReference type="EnsemblBacteria" id="KWX24551">
        <property type="protein sequence ID" value="KWX24551"/>
        <property type="gene ID" value="AFM11_07645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5378"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="28264" checksum="3BBAB71888CF7914" modified="2016-06-08" version="1">MSAERIVMEVTRYQPETDSEPTLQAYEVPLTREWAVLDGLNYIKDRLDGTLTFRWSCRMGICGSCGMTINGDPKLACATFLVDYLPGPVRVEPMRNFPVIRDLVVDISDFMAKLPRVKPWIIRDDELAPEDGEYLQTPAELEDYKRFSMCINCMLCYSACPVYGLEPDFLGPAAIALAQRYNLDSRDEGEPDRRDVLAAADGAWACTYVGECSTACPKGVDPAGAIQQYKLTAAKHSVRDLVMPFRSRRAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQF4</accession>
    <name>A0A132PQF4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_09830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847311.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05395"/>
    <dbReference type="EnsemblBacteria" id="KWX24282">
        <property type="protein sequence ID" value="KWX24282"/>
        <property type="gene ID" value="AFM11_09830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6004"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="6">
        <location>
            <begin position="122"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="7">
        <location>
            <begin position="650"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="768" mass="83780" checksum="CECAC4A938463CA6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQL7</accession>
    <name>A0A132PQL7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdenum cofactor biosynthesis protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08080</name>
        <name evidence="3" type="ORF">AWC31_00015</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000001">
        <property type="protein sequence ID" value="ORX19287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846275.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00015"/>
    <dbReference type="EnsemblBacteria" id="KWX24629">
        <property type="protein sequence ID" value="KWX24629"/>
        <property type="gene ID" value="AFM11_08080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19287">
        <property type="protein sequence ID" value="ORX19287"/>
        <property type="gene ID" value="AWC31_00015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5466"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX19287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="159" mass="16371" checksum="C4BE260ED9E16916" modified="2016-06-08" version="1">MTRSARVVIASTRAAAGVYDDRTGPLIVGWLANRGYDVTEQMVVPDGSAVGEALRSALAEHVDLIITSGGTGISPTDATPQATMAVLDYEVPGLADAIRRAGVHKVPTSVLSRGVCGVSGRTLIVNLPGSPGGVKDGLGVLDHVLEHALDQLGGKDHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQW6</accession>
    <name>A0A132PQW6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_07910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846180.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24510"/>
    <dbReference type="EnsemblBacteria" id="KWX24597">
        <property type="protein sequence ID" value="KWX24597"/>
        <property type="gene ID" value="AFM11_07910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5432"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="485" mass="51429" checksum="F29690FC1E340104" modified="2016-06-08" version="1">MIETVEPLSARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRADLDASPSQLQWVIDIYTLALASVLLLSGAAGDRFGRRRTFQIGLTVFATASLLCSIAPNIETLIAARFLQALGGSMMNPVAMSIITQVFTGRVERARAIGVWGGVVGISMALGPIVGGALIEYVDWRAVFWINLPICALAILLTAIFVPESKSATMRDIDPIGQLLGVAFLFGVVFVLIEGPFLGWDHPLIVGIGVVAVIAFVVFLRFESRRRDPFIDLRFFRSVPFASATGIAVCAFATWGAFLFLMSLYLQDHRGFSAMHTGLIYLPVAVGALIFSPLSGRMVGRFGARPSLLISGALLTTSTLMLTQLTGTTPVWQLLIVFAVIGIGFSMVNAPITNTAVSGMPTDRAGAASAVASTSRQVGVSLGVALCGSALGAALTDNSIDFAAAARPLWLVFAGFGVLIFVLGIVSTSPWALRSAERLAPLIGQHHRSSEVAHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR18</accession>
    <name>A0A132PR18_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08925</name>
        <name evidence="3" type="ORF">AWC31_13445</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846690.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13445"/>
    <dbReference type="EnsemblBacteria" id="KWX24769">
        <property type="protein sequence ID" value="KWX24769"/>
        <property type="gene ID" value="AFM11_08925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18321">
        <property type="protein sequence ID" value="ORX18321"/>
        <property type="gene ID" value="AWC31_13445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5634"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="291" mass="30554" checksum="1E364DD289900208" modified="2016-06-08" version="1">MKAAAFAYHRPATVAEAVHMLGEFGDDAKILAGGQSLVPMLAMRLTHFDNLIDISRVTELNDIDRQDDTVRIGAATPHALVGMDDEVAESVPLLTMATPHIGHFQIRTRGTLGGAIAHADPAAEYAAVALALDATIEATSPRGTREIGAAEFFTGLWETALAPDEILTAVRFPVWSGRCGFGVQEFARRHGDFAIAGAVVGIELDDDNRVSRCGIGLLGLGSTPKRATPAEAAVTGTPIGNVTAEEIGRLAMSQLTDVPADLQGSASYRTRVGAAMVARAWTQASVEALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR67</accession>
    <name>A0A132PR67_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846483.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00350"/>
    <dbReference type="EnsemblBacteria" id="KWX24697">
        <property type="protein sequence ID" value="KWX24697"/>
        <property type="gene ID" value="AFM11_08495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5547"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="324" mass="33742" checksum="8752F1ECB70730AC" modified="2016-06-08" version="1">MKAAVVTQWGETPRYTDVPDPQPRDGAEVANVEASALTNITRGLMSGKHYASKEIQLPAIPGIDGIARLADGRRIYTGALPPYGMMAQRALVNPTGGVEVPEHIDSVVAAAVPNPGMSAWISLSYAAAVQPGDHVLVLGATGVTGSMAVQLAGSAFGAARIVVAGRDTARLKWLRTAGAHDVIALGTDDLGARVAELHAQRPFDAVLDYLWGEPAEQTLTALANSHPAAHHHATRFVQIGSMAGPALNLNAGVLRSTGITLCGVGIGSVPPEVMVQTRAEALPKLFTMVASGELQLRTQARPLSDVEQVWTATGPSGTRVVLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRB5</accession>
    <name>A0A132PRB5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847022.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13120"/>
    <dbReference type="EnsemblBacteria" id="KWX24870">
        <property type="protein sequence ID" value="KWX24870"/>
        <property type="gene ID" value="AFM11_09250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5698"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="375" mass="42267" checksum="DC7D7AFA5E6F228F" modified="2016-06-08" version="1">MGTVEDLHASATKACGLDDFGTDDDNYREALGVLLESYQRDADLTELGSKMQRFFVRNALVARLVSEAAWKQYPQHADVTIEKPIFVTGLPRTGTTVLHRLLTADPQHQGLEMWLAEFPQPRPPRETWASNPVYQQLDAQFSRHHDENPDYTGLHFMTADEVEECWQLLRQSLHSVSYETLAHLPTYARWLAQQDWTKPYQRHRRNLQLIGLNDPGKRWILKNPSHLFALDAVFATYPDALVIQCHRPAETIMASMCSLSQHTTAGWSNSFVGAQIGADALDTWSRGLELFNTERAKHDPAQFLDVDYSEFIADPVGTVENVYRHFGLPYTDGARAAVEAVNAASKKGPRAPKHTYSLADYGLTAEAVKERFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS27</accession>
    <name>A0A132PS27_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_06990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845523.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28660"/>
    <dbReference type="EnsemblBacteria" id="KWX25158">
        <property type="protein sequence ID" value="KWX25158"/>
        <property type="gene ID" value="AFM11_06990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4597"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="32103" checksum="45ED99A85C95B222" modified="2016-06-08" version="1">MSHSDFAELLAVLDLNRIDDNLFIGSHPSKNPVRTFGGQMTAQAYVAGSRSLDHKLAPSALSAHFIAGGDPEKDLEFHVVRLRDERRFANRRVDVMQNGQLLTTVMLSYMNGGRGLEHSVPAPDVPHPDTLPKIDELLRGYEKTVPLFVEALRPIEWRYTNDPAWVMRDKGGKLDHNRVWLKTEGSMPDDPVLHAAALVYSSDTTVLDSIITTHGLSWGFDRIFAVTMNHSVWFHRPIRFDEWVLYSTASPVAAESRGLGTGHFFDISGALLATVVQEGIVKYFPGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSF6</accession>
    <name>A0A132PSF6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_03060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843828.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25288">
        <property type="protein sequence ID" value="KWX25288"/>
        <property type="gene ID" value="AFM11_03060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2481"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="331" mass="33593" checksum="AD42176EDE40D40D" modified="2016-06-08" version="1">MVSIYWNIRTWIALGAALLALGITLAVTPGFSNPGNLYALLQTFAVLALITCGLAMVMIAGEFDLSIAGVVPLAGLLTVKVGESAGIAVGILAALGVSAAVGVLNGWLTARFSVPSLAVTVGTLVATTGLGYAVTDGGVVTMTNYQFGLWLDNAIAGVLSPRTLIALALVGLAVFLMSRTWFGVTIRAVGSDQNRARFSGLPTNRAIIGVFVVSALFAGTAGSLQALSLAAGQPGTNLSLLLQAVTAVIIGGVALTGGKGRLSGVLCGALLLAITSNAMSYHGAATAAIQLVSGVILLAILLLDTPLDRLVKRSLERVSTAAEKEYHHAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSH7</accession>
    <name>A0A132PSH7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03210</name>
        <name evidence="2" type="ORF">AWC31_21885</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843890.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21885"/>
    <dbReference type="EnsemblBacteria" id="KWX25311">
        <property type="protein sequence ID" value="KWX25311"/>
        <property type="gene ID" value="AFM11_03210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16669">
        <property type="protein sequence ID" value="ORX16669"/>
        <property type="gene ID" value="AWC31_21885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2517"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX16669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="263" mass="27004" checksum="FA9FD8D0EC1F266C" modified="2016-06-08" version="1">MILDRFRLDDKVAIVTGAGRGLGAAIAVAFAEAGADVVIAARTQSQLEEVAEQVAAAGRRAHIVVADLAHPESTAELATAAAEAFGKLDIVVNNVGGTMPAPLVNTSAKDLRDAFTFNVSTAHALTAAAVPLMLEHSGGGSIINITSTMGRLAGRGFVAYGTAKAALAHYTRLAALDLCPRIRVNAIAPGSILTSALDIVASNDELREPMEKATPMRRLGDPADIAAAAVYLSSPAGSYLTGKTLEVDGGLTMPNLDLPIPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSI5</accession>
    <name>A0A132PSI5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843809.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25283">
        <property type="protein sequence ID" value="KWX25283"/>
        <property type="gene ID" value="AFM11_03025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2473"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="168" mass="18491" checksum="793C35FA3502A182" modified="2016-06-08" version="1">MSVRIEQIRLVTYRWEAMQRWWSALLNVDFTPVGARTAIAEGPSLCVVLEHSPITMNASSEVAGIATITVSASSVVTASATVDRLSAVGSAPLRATDDLSGIRVWFRDPDGCDVAIRLPFYPAVSNPLNTEVDPLHILDLLRTATPPEDGSNTFERRPPWQPRIRPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PST2</accession>
    <name>A0A132PST2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar basal body P-ring biosynthesis protein FlgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844240.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21300"/>
    <dbReference type="EnsemblBacteria" id="KWX25411">
        <property type="protein sequence ID" value="KWX25411"/>
        <property type="gene ID" value="AFM11_03865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2650"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="1">
        <location>
            <begin position="53"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="220" mass="22227" checksum="E304581A1BCCBE21" modified="2016-06-08" version="1">MAESLNPSALHRLTAALRPDWTRTVAARRAVAAGLVVLAAVAAVRSDPRGDHADIAVATRDLAPGTELTAADVALESRSAATLPDGARSDLADLVGATLAGPVRRGEVLTDVRVLGPRLAESAAGPDARIVPLQLGDAALLDLIRPGDVVDVLTVTEGAEQAGAQPARPVVVATDAVVVLVSDKPKGTGGDRVALVALPARSANEVAAASLVQAVTLTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT71</accession>
    <name>A0A132PT71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sialic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_04655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20490"/>
    <dbReference type="EnsemblBacteria" id="KWX25536">
        <property type="protein sequence ID" value="KWX25536"/>
        <property type="gene ID" value="AFM11_04655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2810"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="494" mass="53364" checksum="2F3FCEAF1C6DB638" modified="2016-06-08" version="1">MVSTVGGSTKEPTVWYRQLTRRQWKAFVASWLGYLLDGFDFVIITLVLTEVIREFQLTPVMGATLVSAAFISRWFGGLALGAFGDRFGRKNAMVVSIALFSLGSVLCAIAPGYWVLFAARLLIGLGMAGEYGSSSTYVIESWPKHMRNKASGFLISGFSIGAVLSAQAYRFVVPEWGWRALFAIGLVPIALALWLRRTLPESDDWERAREQHHAGTRTAAPDMFSTLYKGRRSVFNVVATILAFGALLLIFTHTVGNPFAVAALALLAAAVFVSFMVQFEGSRWPTGLTVMVVIFTAFLYSWPIQALLPTYLKTDLELDPADVANILFFSGFGAAVGCVVAGFTGDRFGTRRAYWMSLVISQVLIFPVFLVGGHNLLVLGLLLFLQQVFGQGISGLLPKWIGGYFSVEKRAAGLGFAYNVGALGGAVAPVLGAGLATKMPLGTALAVLSFGLTAVVIVLIGINAPQRVQRLVKPEHVWPTDSTETMPDAAPADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT75</accession>
    <name>A0A132PT75_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrodipicolinate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_04690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844594.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20455"/>
    <dbReference type="EnsemblBacteria" id="KWX25541">
        <property type="protein sequence ID" value="KWX25541"/>
        <property type="gene ID" value="AFM11_04690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2818"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="142"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="349" mass="36691" checksum="4D0796E807377A4C" modified="2016-06-08" version="1">MALKVVQWATGGVGVAAIKGVLEHPDLELVGCWVHSETKNGRDVGDLIGTQPLGVIATNNVDDILALNADAVIYAPLLPDANEVAALLRSGKNVVTPVGWIYPGERQGAALREAAQAGNATLHGTGIAPGGISEKFPLLFSVMSTGVTFVRAEEFSDLRTYDAPDVVRHVMGFGDTPDKALSGPMQKLLDGGFIQAVKLVVDQAGFNADPRIRASQEIAVATAPIESPIGVIEPGQVAARKFHWEALVDGEPVVRVTVNWLMGEENLDPAWTFGPEGQRYEMEVRGNPDFTVAIKGFQGEAGDDGPEPGVVATAAHCVNSIPAVCAAEPGIATYFDLPLFSAKAAPGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTF5</accession>
    <name>A0A132PTF5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="4" type="ORF">AFM11_05135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844749.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20105"/>
    <dbReference type="EnsemblBacteria" id="KWX25616">
        <property type="protein sequence ID" value="KWX25616"/>
        <property type="gene ID" value="AFM11_05135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2908"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="70" mass="7897" checksum="BF2F6E04D57EBFF1" modified="2016-06-08" version="1">MKPISELGYEDARDELIEVVQQLEQGGLDLDSSLKLWERGEALAKRCEEHLAGARERVEQALAARESEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTK0</accession>
    <name>A0A132PTK0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25656">
        <property type="protein sequence ID" value="KWX25656"/>
        <property type="gene ID" value="AFM11_03150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2504"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="178" mass="20041" checksum="5F4D4CD405658EC6" modified="2016-06-08" version="1">MLGAEGSRGLTHPRLDRHAGLPAGTTSYYFRTRKALLHGVAERITELDLADLSMLDEHSDRFDPHYGGTLGLARLVLLAGMEPYLTRTRARFELILYSHQDDELAATLRSYSVQFYGLAREVIARWYDDPTVLPVEIEERAVVVLTFISGVLTSLVHGNPVTNDASHLDQLIRQLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTM3</accession>
    <name>A0A132PTM3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25663">
        <property type="protein sequence ID" value="KWX25663"/>
        <property type="gene ID" value="AFM11_03370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2548"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="484" mass="49011" checksum="797D64D5AFF3AF6E" modified="2016-06-08" version="1">MATATLLAADEEATATVGDDLLLGLTIGSVVLIIVLIAWTKLHPLIALIAGSAVLGISSGLGAGATIESFTDGLGGTIGDTGLLIALGAMLGQLLNVSGAATSLVDRFVHAVPPRAIPWAMAGIAFLIGLPLFFEVALVLMFPIIVLVVRRTGMPLLKVAMPALASLSLLNGFLPPHPGPLLAVSAFNADLGRTLLFGIIVAIPTVVIGGPLLGNVLNRWVPSPDVKTLLFGGEADRTDKPGNDEPSGSGGTTTLAPPKPSLKVPGTTATLVTMLLPVALMLIRAIAELVLAEGNTVRHAAELIGEPTVALFAGCVTAMFTFGLATGMGKDKVGSVMGSGLPLVAGIIMIVGAGGGFKSTLVATGVGDVIADHAHSLGLPTLMLGWLLAALIRIAVGSGTVAIVTTAGLLAPLAAGMSPNQAALMALAIGAGSRFMSHVNDAGFWMVKEFLNLSVKDTFRTWTVMDCTVSVVAGIGVMILGAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTZ1</accession>
    <name>A0A132PTZ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00390</name>
        <name evidence="6" type="ORF">AWC31_33505</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842220.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33505"/>
    <dbReference type="EnsemblBacteria" id="KWX25790">
        <property type="protein sequence ID" value="KWX25790"/>
        <property type="gene ID" value="AFM11_00390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11604">
        <property type="protein sequence ID" value="ORX11604"/>
        <property type="gene ID" value="AWC31_33505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.79"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="125" mass="13543" checksum="BC6B8E34CB6FED96" modified="2016-06-08" version="1">MTTDWIAVASTKELARRRKLRVTLDGSDGAAGLAIALFEAAGQVYAFADSCIHQDRSLAKGTLLHGKVICPGHQWQFDLETGYEESQDRCQPTYPVRVEDGTVYVNPTARMSAVATGSDGKEAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU14</accession>
    <name>A0A132PU14_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842329.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25831">
        <property type="protein sequence ID" value="KWX25831"/>
        <property type="gene ID" value="AFM11_00610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.125"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="289" mass="32321" checksum="2DF3422FA754433D" modified="2016-06-08" version="1">MSVGVERTAIGPTLIVAIDQHEDPPLVPDPWAQRILPRPWRIPLTLSRFGPVRRAMVAATEQSVPGGWASLLCRKRYIDDLLREAAGRGLDAVVLLGAGYDTRAYRVAELAGMRIWELDLPANIAAKTQALRRCFGRIPANVTLLSVDLETDDVLDQLCRNGFDSNMRTFFVWESVTMYLPDAVVRRTLDSLSGSPVGSCLAFTFFRKDFVDGSNLYGADRAHQKFVAEHGLWKFGVNPDELGGILAEYGWRQIEQLGPAEYRERYLRPSGRDQPVSEIERAAFAERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU90</accession>
    <name>A0A132PU90_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842557.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34070"/>
    <dbReference type="EnsemblBacteria" id="KWX25906">
        <property type="protein sequence ID" value="KWX25906"/>
        <property type="gene ID" value="AFM11_01040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.213"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="28503" checksum="E1E764D2283A6DDC" modified="2016-06-08" version="1">MRVAIAQFGPTTDTTANLAAIDRLTAHAAADSADVIVFPEEAMLSVDGLDHRLSELVDLQWPLFEAHLSGLAASHDIAIIAGGYEPNGTSRPNNTLVAVDSGGDILTRYRKLHLYDAFAYRESDYVTPGPTLPPVVDLAGLRIGLVNCYDLRFPELTRHLISQGAELISVSAAWMSGHRKADHWETLVRARAIENTVWVAAAGTISSACIGDSLVVDPLGVVKAALGDEPEAVVTVEISTARTQAVRTVLPALDNRRIELTMTVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUB2</accession>
    <name>A0A132PUB2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">groEL</name>
        <name evidence="9" type="synonym">groL</name>
        <name evidence="13" type="ORF">AFM11_01205</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842642.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34245"/>
    <dbReference type="EnsemblBacteria" id="KWX25931">
        <property type="protein sequence ID" value="KWX25931"/>
        <property type="gene ID" value="AFM11_01205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.247"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="478"/>
            <end position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX25931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="539" mass="55756" checksum="20A356A6910CE598" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUF1</accession>
    <name>A0A132PUF1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_01465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842787.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25971">
        <property type="protein sequence ID" value="KWX25971"/>
        <property type="gene ID" value="AFM11_01465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.300"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453639" evidence="2">
        <location>
            <begin position="34"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="354" mass="36967" checksum="FDE00B375B6E3947" modified="2016-06-08" version="1">MTSTKYIGYVGGVAVAVGVGAAIAAAGQGTAHAESTDSGSKDTTSSSSSSPNTGPKKPTTNTGSKSESKSDSKSDAKPDRPKPLSKLNDNLEKAGEKLNEQVTKAVSTVSKTISDSLAKPAAKPETKPAPKPSAEEFEAEQVAKLKNLFTPKQAAAPKPDSTLDTEPVAEPANTTVVSSPKVAAAVETQADTAADTPWSPNPFRPDDQEPEPTDIPDEIMELRDALRALTPEALDAFDPFIREATEQIYRGSQIVPWVNAVIPISKILPALAPGLGSGPEGDRARQLIINELIKTTPIGSFAYYGYDIAADLLNLEDPAAVLKDQAVATVWDILDPFELAHVKGESGIGNAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUP1</accession>
    <name>A0A132PUP1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gamma-aminobutyraldehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_01950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.19" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843004.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34730"/>
    <dbReference type="EnsemblBacteria" id="KWX26035">
        <property type="protein sequence ID" value="KWX26035"/>
        <property type="gene ID" value="AFM11_01950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.400"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033737">
        <property type="term" value="F:1-pyrroline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019145">
        <property type="term" value="F:aminobutyraldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="22"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX26035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="496" mass="51800" checksum="EB8F0403F6200958" modified="2016-06-08" version="1">MSVAVNVASSWINGAPASTTGPTHSIIDPATGNTVAEYALGTPADVDAAVAAARSALPGWSSATPAERSAVLAKLAKLADENAEQLVAEEVSQTGKPVRLASEFDVPGSIDNIDFFAGAARHLEGKASAEYSGDHTSSIRREAVGVVATITPWNYPLQMAVWKVIPALAAGCSVVIKPAEITPLTTLTLARLATEAGLPDGVFNVVTGAGSDVGTALAGHRDVDVVTFTGSTAVGRKVMAAAAVHGHRTQLELGGKAPFVVFDDADLDAAIQGAVAGALINTGQDCTAATRAIVARDLYDDFVAGVAEVMSKVVVGDPHDPDTDLGPLITAAHRDKVAGMVARAPEQGGRIVTGGAAPDLPGSFYRPTLIADVSESSEVYRDEIFGPVLTVRPFTDDDDAIRQANDTVYGLAASAWTRDVYRAQRASREINAGCVWINDHIPIISEMPHGGVGASGFGKDMSDYSFEEYLTIKHVMSDITGVAEKDWHRTVFTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUR3</accession>
    <name>A0A132PUR3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_02325</name>
        <name evidence="6" type="ORF">AWC31_35105</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843206.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35105"/>
    <dbReference type="EnsemblBacteria" id="KWX26098">
        <property type="protein sequence ID" value="KWX26098"/>
        <property type="gene ID" value="AFM11_02325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11876">
        <property type="protein sequence ID" value="ORX11876"/>
        <property type="gene ID" value="AWC31_35105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.476"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="217" mass="24073" checksum="11B5C9F329B85E36" modified="2016-06-08" version="1">MGAESRRRLSPADRRSELLALGAEVFGQRPYDEVRIDEIAERAGVSRALMYHYFPDKRAFFAAVVRAEGERLFEATNTPPEPGQSLFGQLRAGVLAYLRYDEEHPHGAWAAYMGMGRADPVLRGIDDLDNDRQANRIMSRIGEAAAEPLDPKLERDLRATIYGWLALTFEMCRQRLVDPSIDAGFVADTCAHALLDAVGRVPGLPPELADAAAPEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV57</accession>
    <name>A0A132PV57_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peripla_BP_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843570.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33755"/>
    <dbReference type="EnsemblBacteria" id="KWX26216">
        <property type="protein sequence ID" value="KWX26216"/>
        <property type="gene ID" value="AFM11_00645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.132"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="37536" checksum="99859F3D48985A17" modified="2016-06-08" version="1">MVVPLQGPAGLFGPSCEAVADLVAHDLNAAGGVLGREVHIEVVDGGAHPAAVAADVKRLIDEDRIDAVSGWHISSVRNALAPVVAGRVPYSYPALYEGGERRRGIYCCGETPDQQIAPALRWLRDNLGIKKWFVVGDDYVWPRTSLAEVRRYVRELSLDLVGGSFVALGHGDIDRLVDKAAQSRCEAVLMLLVGQDAVEFNRSFARRGLHENLLRFSPLMDENMLIASGHEATQGLFVAASYFRSMIGRNSMELLDRYLTVNGSNAPALGNAAESCYEGAHFLAQMIHRSGDYRDIEAVADGAAYDSPRGTVEFMKRRTRQPVHLAVASGVDFEIVTTLPSDLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVA2</accession>
    <name>A0A132PVA2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ligand-binding protein SH3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_01895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843684.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34685"/>
    <dbReference type="EnsemblBacteria" id="KWX26271">
        <property type="protein sequence ID" value="KWX26271"/>
        <property type="gene ID" value="AFM11_01895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.389"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX26271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="105" mass="10772" checksum="36A9459015E598F1" modified="2016-06-08" version="1">MAWLILVVSGVLEAVWATALSKTEGFTRLGPSVVFGVALILSMIGLAIAMRSLPPGTSYAVWVGIGAVLTVTYAMLTGGESASLIKVLLMLGVVGCIVGLKVVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVC0</accession>
    <name>A0A132PVC0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843661.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26260">
        <property type="protein sequence ID" value="KWX26260"/>
        <property type="gene ID" value="AFM11_01695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.349"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="20818" checksum="8C51455B6DC895D1" modified="2016-06-08" version="1">MGTATRPYIVGLGGTLRPGSSTESALRIALDEARAAGADTELFGGADLARLPMYDPESENVDEALRLVESLRRADGVIIASPGYHGSVSGLVKNALDYIEDLREDGNPYLSGRSVGCVTTAYGWQAAVTTLQTLRSIVHALRGWPTPLGAAINSATTRIAYGEDPDERVGFQLRTVGREVCMRSSATHPAGGLAAISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAU5</accession>
    <name>A0A132PAU5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000049">
        <property type="protein sequence ID" value="KWX19455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31650"/>
    <dbReference type="EnsemblBacteria" id="KWX19455">
        <property type="protein sequence ID" value="KWX19455"/>
        <property type="gene ID" value="AFM11_35760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5888"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="17872" checksum="522389A5ADFDF6E2" modified="2016-06-08" version="1">MSTETRVDTLDARILKALNADPRATVIALADKTQLSRNTVQVRINKLEQLGVLRSFERRIDPATLGYPLTAFILTRVTQRKLAAIAQALEQVPEVIEVQGLAGATDLLIHVVAREADDLYRVAGQILDIDGVEQTNTSLVMRKLVDFRLTPLLEKLAETEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB66</accession>
    <name>A0A132PB66_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19556">
        <property type="protein sequence ID" value="KWX19556"/>
        <property type="gene ID" value="AFM11_35295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5789"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="350" mass="38044" checksum="FCC7DEB55015F0E0" modified="2016-06-08" version="1">MAAYAALSLNYFADDIVLSGGPGSDYLEFHEVYSQFTFVEKCAFDIALRVIETERGITISLKDRANVVTDFVSCLRESSQGRVYYPEGVGATELADILRELAEPTIQPDVDKKDEPPEPKPTPDHPEPPPPPKRSRWRALIITATAVVVVASLLAAGWGIWRWGLSSGRHDRPPLIDAGPARSGVPLGTNVSIRMLATYKGSDGQPKTVETVSGIAPETPAIVTFPADPETAVLSLQLHLTLTERTEKADPDLKIAFGDNPLLPVGDTYRTDPEHPNGERVPALTVSPEDTHLKLGDTDTVYQFDAALGDPDDYWCGYNTKPMVVYATNGTDPMVVASLPVVVFKDCTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC49</accession>
    <name>A0A132PC49_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="8" type="ORF">AFM11_33375</name>
        <name evidence="9" type="ORF">AWC31_02340</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858665.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02340"/>
    <dbReference type="EnsemblBacteria" id="KWX19874">
        <property type="protein sequence ID" value="KWX19874"/>
        <property type="gene ID" value="AFM11_33375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13378">
        <property type="protein sequence ID" value="ORX13378"/>
        <property type="gene ID" value="AWC31_02340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5007"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX19874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX13378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="79" mass="8692" checksum="2383FE554E365711" modified="2016-06-08" version="1">MKTGIHPEYVETTVHCGCGNTFTTRSTKQSGQIVVEVCSQCHPFYTGKQKILDSGGRVARFEKRYGKRKPAGDKAAADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC93</accession>
    <name>A0A132PC93_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_34990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859599.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02030"/>
    <dbReference type="EnsemblBacteria" id="KWX19602">
        <property type="protein sequence ID" value="KWX19602"/>
        <property type="gene ID" value="AFM11_34990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5727"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="136"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="3">
        <location>
            <begin position="243"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="404" mass="43392" checksum="AE048406F63F180C" modified="2016-06-08" version="1">MTTVENVTRILPGTPEWSDLLAKIAAGAKDRDLNDENPFDQVNALKRAGFGALRLPESLGGAGFTVPQLFSAVIDVAHADPIVAHIFRTHFWFTEERLRTADDPISAHWLRKVSEGKIFGNAFSEKGSLAVGSLVFNTRLLPDPAGGFRLNGEKYYSTGTLFSDYLTVAATTDHDSVASVLVPTDRDGVRLVDDWDGFGQRRTGTGTTTFTDVAVAADEVLVDTPYDAEPTPTVQYASLQLFIHAVVAGILANVVDDGVALLRSRDRNFNHAIAEKPTEDPLLQRQLGVLASTAYVARAAVLDAAAAIGAATDSAVDGVPDAQLAAEAQLKVAKVKVHLDDVAPEAATRLLELGGASAASRQRNLDRHWRNIRTITLHNPVAYKARVIGQNLLHGTPVPANAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCK0</accession>
    <name>A0A132PCK0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_33000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858402.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32445"/>
    <dbReference type="EnsemblBacteria" id="KWX20024">
        <property type="protein sequence ID" value="KWX20024"/>
        <property type="gene ID" value="AFM11_33000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4930"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="297" mass="32469" checksum="0F075459A3281ACD" modified="2016-06-08" version="1">MRSDNDTWDITTSVGQTALFVAASRALEARKPDPLAVDPYAEVFCRAAGGDWAAAVDGTDPDHPLRTEFGAHFVNFQGARTKYFDDYFRRAIEAGVRQVVLLAAGLDSRAYRLPWADGTVVYELDQPRVLEFKRQTVEELGEKATAERREVAVDLRDDWPQALTAKGFDPTKPSAWIAEGLLIYLPAPAQDRLFAGIDGLAAPGSFVAVEEAVPMPREAFEAKRAEAKASGEENAFFTLVYNEQHAPAEQWFSSRGWTAATTALPDYLRQLGRPVPAADSEAGLMTGTISLVTATKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD10</accession>
    <name>A0A132PD10_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_32110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31740"/>
    <dbReference type="EnsemblBacteria" id="KWX20184">
        <property type="protein sequence ID" value="KWX20184"/>
        <property type="gene ID" value="AFM11_32110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4748"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452980" evidence="2">
        <location>
            <begin position="35"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="105"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="237" mass="24400" checksum="094DFE71C4089403" modified="2016-06-08" version="1">MGGGPPVRRRDAISAGGLVALSLAVGFSPGVAEADSEQWDPTLPRRVSAGAPGDPVAIANASLAATRLAADTTLGLGRQFLGSLGILDDPTPSPAALRTGRVRGPQAIEYVIRRAGSQLGVPYSWGGGSLTGPSKGVDSGADTVGFDCSGLTRFAFAGVGVLLPRWSGDQYTAGRQVSRSQARRGDLLFWGPGGSQHEAIYLGGGRMIEAQQTGVPVKVSPVRLSGMTQYVTRVIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD50</accession>
    <name>A0A132PD50_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetolactate synthase</fullName>
            <ecNumber evidence="5">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_31890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20147">
        <property type="protein sequence ID" value="KWX20147"/>
        <property type="gene ID" value="AFM11_31890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4704"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="199"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="398"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX20147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="589" mass="62870" checksum="8A06BC465B50D1D7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDF2</accession>
    <name>A0A132PDF2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_30925</name>
        <name evidence="7" type="ORF">AWC31_26645</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857196.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26645"/>
    <dbReference type="EnsemblBacteria" id="KWX20365">
        <property type="protein sequence ID" value="KWX20365"/>
        <property type="gene ID" value="AFM11_30925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14744">
        <property type="protein sequence ID" value="ORX14744"/>
        <property type="gene ID" value="AWC31_26645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4087"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX14744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="220" mass="23628" checksum="742924A6CBC2C772" modified="2016-06-08" version="1">MTAESLPEGSNGPVGAPASPQARRSRGDRQRDAIVKAVRELLEKESFADLSVSTISERAGVARSGFYFYFDSKYAVLAVILADAMEELAALTHDYAPREPGETPAAFAKRMVGSAAAVFATNDPIMSACTVAQNTDAQIRELMNDFEDVVIGKIVGLIEQDEGARPISDDLPALVRTLTATTAMTLSHDSAFVGRDTDPGRALEIVERLWLNALWGGLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDU0</accession>
    <name>A0A132PDU0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856928.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00455"/>
    <dbReference type="EnsemblBacteria" id="KWX20490">
        <property type="protein sequence ID" value="KWX20490"/>
        <property type="gene ID" value="AFM11_30450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3989"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="127" mass="14784" checksum="363D4818F296AD32" modified="2016-06-08" version="1">MRTRGFGELEAVIMDRIWNRRSDTPVTVRDICNELSSERNIAYTTVMSTMDNLHTKGWLARIRDGKAYRYWPTLTREQHSAKMMREALDSGGRVDLVLGYFLDQIGPEDSARLRVALGRSRQRVREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE77</accession>
    <name>A0A132PE77_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856674.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25355"/>
    <dbReference type="EnsemblBacteria" id="KWX20631">
        <property type="protein sequence ID" value="KWX20631"/>
        <property type="gene ID" value="AFM11_30015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3895"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="PTHR11056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="363" mass="41099" checksum="B9425288E2D169AB" modified="2016-06-08" version="1">MESFVHLRKGKTPKRIHADLDGLKDDELGRGGFVGRTANMYRRNDPTAYRTVGPLRPTDVLSSELKPSDNTDAHGGPLLMFSNADCQVLLSRRSEEMPFFVRYVDGDLLLFVHKGSGLLETEFGPLRYREGDWVYIPKACTFRQVPDAESTWLMIQATDDFRVPPAGTLGRHFPFDPAQVTIPEPAPIDDDGRDEYEVRIVHEGGPTSLFYQHNPLDVEGWRGDNFPFTFNIEDYTVITSESVHLPPTVHLFMQATGVYVMNFLPKPAESVPGTERTPWYHRNVDYDEIAFFHAGSLYGIPMPPGLISHAPQGVHHGAPEKARERARRKFDEYDRVDWSVIAIDTRRRLVPSAEILANDLGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEA3</accession>
    <name>A0A132PEA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040099.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20669">
        <property type="protein sequence ID" value="KWX20669"/>
        <property type="gene ID" value="AFM11_29000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3681"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="2">
        <location>
            <begin position="129"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="373" mass="39274" checksum="5A34A9E67737D6D8" modified="2016-06-08" version="1">MTSLLGTHVTRRYRNVLSIGVIAVLSGCSSGLESLPLSSPSVGGETYTLTAVFTNALNLPAHAKVKVGGADIGEVEKIQAKEFTAQVTMRIREDVSIYDGATVELRSATPLGDLFVAVQPHPDQQSASTPLADGDVIPLAATSAGATVEELLSSAAVLVNGGVIRSLTHILNGAGSAVGDSGTKIADLLHQSNRLIAQLNARSDEITEALHRTSELASSLSARQHTINAALAAADPAIAVIADNRDQIVALIGSVARTTRQLSRFPSLQGTDSRSLIADLNRLSDAFNDASIDPNTSLTTFNRIVPRLLKLTSGANLHAAGDVEQIALGALPDMNYPGDPMTHGPDGTDWHAMIGSLRYQWNLLLNRIYGPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEI4</accession>
    <name>A0A132PEI4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_29460</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047041000.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27335"/>
    <dbReference type="EnsemblBacteria" id="KWX20733">
        <property type="protein sequence ID" value="KWX20733"/>
        <property type="gene ID" value="AFM11_29460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3783"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="522"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="554"/>
            <end position="561"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX20733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="870" mass="93738" checksum="3B17B9B295D64EB4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEM0</accession>
    <name>A0A132PEM0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
            <ecNumber evidence="1">4.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.12" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856160.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32790"/>
    <dbReference type="EnsemblBacteria" id="KWX20786">
        <property type="protein sequence ID" value="KWX20786"/>
        <property type="gene ID" value="AFM11_28535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3585"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008473">
        <property type="term" value="F:ornithine cyclodeaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="32358" checksum="2D04E146192D225C" modified="2016-06-08" version="1">MIPAAEIAERLPFDRLIPALRSAFVTGAEVPTRHHHDIGAAGTLLLMPCWVDGGFLGVKVAGVFPGNRDHGQPSLHSTYLLCDASTGEQLAVLDGAELTRRRTIATAALAADYLARPDAHTLLVVGSGAVASLAAHAYSAIRPVKDVLVWNIRPAGAETLAATLRGEGLDARVATDLGTAAAEADIISCATLATAPLLRGAWLRPGVHVDLIGSFRPDMREADDELIRAGSLFIDTPDAIEESGDLTQPLHDGALSPDDVRATLTELCRGQHAGRRDAAEITLFKSVGTALTDLAAATVVYGSVTGTSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PER2</accession>
    <name>A0A132PER2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">AFM11_28710</name>
        <name evidence="6" type="ORF">AWC31_32940</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003881823.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A132PER2"/>
    <dbReference type="STRING" id="59750.AWC31_32940"/>
    <dbReference type="EnsemblBacteria" id="KWX20811">
        <property type="protein sequence ID" value="KWX20811"/>
        <property type="gene ID" value="AFM11_28710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11505">
        <property type="protein sequence ID" value="ORX11505"/>
        <property type="gene ID" value="AWC31_32940"/>
    </dbReference>
    <dbReference type="GeneID" id="66732799"/>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3621"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="55" mass="6452" checksum="7A1D1286013FB0B6" modified="2016-06-08" version="1">MASSTDVRPKITLACEVCKHRNYITKKNRRNDPDRLEIKKFCPNCGTHQPHKESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PER7</accession>
    <name>A0A132PER7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20717">
        <property type="protein sequence ID" value="KWX20717"/>
        <property type="gene ID" value="AFM11_29335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="124" mass="14142" checksum="4E3FF86A0D22D282" modified="2016-06-08" version="1">MQRVAVELFGSLLPARMVWCSVTVCQMSTSTVSDHDIAAARAADVRQADYYRGELSRQRELLIDRMAAHEAALAKYQLRGEMNQVHRIRREIRHREQEQYALQRLLDAIEERFPAAAGPGPAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF12</accession>
    <name>A0A132PF12_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Beta-lactamase</fullName>
            <ecNumber evidence="2 4">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ampC</name>
        <name evidence="7" type="ORF">AFM11_28010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-C beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2 4"/>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855799.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A132PF12"/>
    <dbReference type="STRING" id="59750.AWC31_10530"/>
    <dbReference type="EnsemblBacteria" id="KWX20928">
        <property type="protein sequence ID" value="KWX20928"/>
        <property type="gene ID" value="AFM11_28010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3476"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017001">
        <property type="term" value="P:antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001586">
        <property type="entry name" value="Beta-lactam_class-C_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00336">
        <property type="entry name" value="BETA_LACTAMASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453219" description="Beta-lactamase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="6">
        <location>
            <begin position="36"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="388" mass="41236" checksum="DF4A0C97D15C30CC" modified="2016-06-08" version="1">MAALLRAVGAVLVAAIALVSTASQAAGSPDAVQAAVDRAFRPLLEQYDVPGMAVAVTVDGRRYFVDYGLAANPGGPAVSRHTLFEIGSVSKAFTATLASYAQATGALSLDAHPSAYLPELRGSAVDAATLRDLGTYTAGGLPLQFPDTVTDDAGMLAYFREWSPTAAPGEIRRYSNPSIGLLGHLTSRAMRGDFADLMQAQVFSRLGLSSTYIHVPDSAMDRYAWGYDKANEPTRVSPGVFDAEAYGIKTSAADLIGFIEANIAPHRFDQSLQRAIEGTHVGYSRVRDMVQGLGWERYPYPVSLDVLLAGNSSTMAMEPQPALPIAPGRLPDGPALFNKTGSTDGFGSYALFVPDRQIGIVMLANKNFPIPARVTAAHAVLQELEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF36</accession>
    <name>A0A132PF36_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855908.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10785"/>
    <dbReference type="EnsemblBacteria" id="KWX20959">
        <property type="protein sequence ID" value="KWX20959"/>
        <property type="gene ID" value="AFM11_28235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3521"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022402">
        <property type="entry name" value="F420_OxRdatse_MSMEG3544_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03854">
        <property type="entry name" value="F420_MSMEG_3544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="31307" checksum="998370817C227857" modified="2016-06-08" version="1">MKVRFGVGLGADTGPEALGGIVDELESAGVDSVWFSELVYTPAVDPFIGMAYALARTTRLKVGTSVAILPGRHPVLVAKQLASLAALAPKRVLPVFGLQSALTAERAVFAVPPGRRAAVFDESLQLLRAVLRQRDVSFEGEFFNVPAADVQPLPAHPLEIWLGGSAPSALTRIGRFGDGWLGSFLTPPEAAAARQRIERAAEAAGRAVEPDHYGISLAVADGRLPADTVAAVRRRRPDVDPAELIATDWPALHRQLDAYLAAGLTKFVIRAAGPTDRDAFLARFVEELLPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF74</accession>
    <name>A0A132PF74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_27920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855994.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10440"/>
    <dbReference type="EnsemblBacteria" id="KWX20985">
        <property type="protein sequence ID" value="KWX20985"/>
        <property type="gene ID" value="AFM11_27920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3458"/>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP_CH_N" evidence="7">
        <location>
            <begin position="16"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GTP_cyclohydro2" evidence="6">
        <location>
            <begin position="242"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="422" mass="45229" checksum="77FBD0D4F81AA9CF" modified="2016-06-08" version="1">MVAESGPGTSPTPNRHIRLTSHSGAVDALTIRWGAATAKDRGPVIGTTTTRAHRHVIGTHSGSYSVYRALAVAAGALSPAHRADLTNTAPTDVIGPYPQWSEPGAIVSLDPWGAMVADAFTTELAAGYDIRPTIAVTKAHVMLPEITDAIARGRLNPDGRTLLSNGAALVTKAAIEPVWYLPGVAARFGCSENALRRVLFEETGGMYPELVTRGDLEVFLPPIGGQTLYIFGDARDLADPAVELTARVHDECNGSDVFGSDICTCRPYLTHAIEECIQGAQRGGVGLVAYYRKEGRALGEVTKFLVYNARKRQAGGDTADQYFARTECVAGVQDMRFQELMPDVLHWLGIRKVHRLVSMSNMKYDAIVGAGIEVGERVNIPDELIPADARVEIDAKMAAGYFTPGPVPDADELKIAKGRGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF79</accession>
    <name>A0A132PF79_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_27670</name>
        <name evidence="6" type="ORF">AWC31_10205</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX09045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855950.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10205"/>
    <dbReference type="EnsemblBacteria" id="KWX20973">
        <property type="protein sequence ID" value="KWX20973"/>
        <property type="gene ID" value="AFM11_27670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09045">
        <property type="protein sequence ID" value="ORX09045"/>
        <property type="gene ID" value="AWC31_10205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3408"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="213" mass="23205" checksum="D133C29B67776E34" modified="2016-06-08" version="1">MRVVVADDAVLLREGLVRLLTENGHAVVAAVGDGPSLVQAVEDHRPDVSVVDVRMPPSHTDEGLRAAVEARRRVPRSPVLVLSQYVELSYADDLLADRAGAVGYLLKDRVAAIAEFLDAVDRVASGGTVLDPEVVAQLLLRRRDDPLGELTQREREVLALMAEGRSNTNIARTLSVSDATVEKHVGNIFTKLMLPPDEEQHRRVLAVLAFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFC3</accession>
    <name>A0A132PFC3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_26990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855250.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06840"/>
    <dbReference type="EnsemblBacteria" id="KWX21035">
        <property type="protein sequence ID" value="KWX21035"/>
        <property type="gene ID" value="AFM11_26990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3272"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="165"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="11">
        <location>
            <begin position="513"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX21035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="929" mass="103451" checksum="D87E2A5E9E4010D1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFF0</accession>
    <name>A0A132PFF0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX21004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856034.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10735"/>
    <dbReference type="EnsemblBacteria" id="KWX21004">
        <property type="protein sequence ID" value="KWX21004"/>
        <property type="gene ID" value="AFM11_28185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3512"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="455" mass="46365" checksum="3C77249ADE4C4A70" modified="2016-06-08" version="1">MDAVLGVSLTPSTVGLVLVEGHEADGATVDHETYDIRDLEPLALAEVTDRVVAAVARAEAITAERGNRLQSIGVTWSDGADIEASQLLSALSDAGFANVLPIRFPQATDTLARGIAGVVGFDTTVVCVIEPELILALTASPGDGPVQTTQVHGIETVQGLADWLCGLFAAATSRPDALVVVGSAVDFDAVMPKLQAALEVPVFTPADEGVALARGAALASARRGRFMFTEPARGPERRHWGPAQLAPAVMLAVGVITFVVSLSLAISHHVAAPEPEAGPRQTRPVVNVSGAPAATQHIPAAVIPPAPTSIPEVAPVVVEPPAAVEPAAPEFITEPEAGAVPADVPPPVVVPPAPAPEAVPPVLSPPVPTKKPLLTRIRDRLRGGPDVPEQQPFMGPVPPAPNAPPPGAVPPPVAEAPPPVGPEPAPPPPAPPAEMPPPEVVPPPLPPPAPPPPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFN8</accession>
    <name>A0A132PFN8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855580.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07270"/>
    <dbReference type="EnsemblBacteria" id="KWX21145">
        <property type="protein sequence ID" value="KWX21145"/>
        <property type="gene ID" value="AFM11_27335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3341"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="2">
        <location>
            <begin position="227"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="614" mass="65360" checksum="4111E96A5E063C75" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFT2</accession>
    <name>A0A132PFT2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855379.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07205"/>
    <dbReference type="EnsemblBacteria" id="KWX21077">
        <property type="protein sequence ID" value="KWX21077"/>
        <property type="gene ID" value="AFM11_27270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3329"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="205" mass="22261" checksum="0118EF1D337E4E0E" modified="2016-06-08" version="1">MTGTYQYPESVPPQQYPEQVPSAYPGMLPPPVQYPKRRRWPRILAVVLAVAVVGAVLTVVIVFGRGGSTQSGVVSDEQARAAVQEYLTALIDGDDETVARHTLCGLFDAVKERKTDLAVAGLASDAFRKQFSKAEVVRIDKIVPWSTTQAQVLFTMRVAPASGSARGQRAPDQEQQGVAQVLVEKDGQNENVLVCSYVLRTGGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG48</accession>
    <name>A0A132PG48_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium transporter Kef</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25580</name>
        <name evidence="4" type="ORF">AWC31_24700</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854423.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24700"/>
    <dbReference type="EnsemblBacteria" id="KWX21301">
        <property type="protein sequence ID" value="KWX21301"/>
        <property type="gene ID" value="AFM11_25580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14413">
        <property type="protein sequence ID" value="ORX14413"/>
        <property type="gene ID" value="AWC31_24700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2979"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="156"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX14413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="364" mass="39243" checksum="A9A1EE18B80E323F" modified="2016-06-08" version="1">MAKGRLRRRLAAIDPNLTSRPDAALVDVLRIPEPFVSPGRKIAMRVMYALGALFAAVLIVYLDRHGYRDIESAPDENNPLSFLDCLYYATVSLSTTGYGDITPYTESARLVNVLVITPLRVAFLIVLIGTTVETLTTQSRQALKIQRWRSRVRNHTVVIGYGTKGRTAVAAMVGDEVAPADIVVVDESLSALERARSAGLVTVHGDATKSDILRLASAQHAKAIIVATDDDASAVLVTLTARELAPKAKIIAAAREAENQHLLRQSGADSTVVSSETAGRLLGIATQTPSVVEMMEDLLTPDAGFAIAEREVSPKEEGGSPRHLHDIVLGVVREGRLVRVDAPEVDALEAGDRLLYIRSADAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGB5</accession>
    <name>A0A132PGB5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854622.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35900"/>
    <dbReference type="EnsemblBacteria" id="KWX21371">
        <property type="protein sequence ID" value="KWX21371"/>
        <property type="gene ID" value="AFM11_26000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3065"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="161"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="409" mass="43973" checksum="26C607593E06B3F9" modified="2016-06-08" version="1">MAEDAVIEELAAAVERSPELAELRLHLATLLVERRRYAEALTHCSAVLAQDAANARAVALLQQCTAGLAGAPAPAAPAAPADAARTFDWSAAEEQVADIVKPAFVEEPAEAVNEYDFDAVRSSAVRLSDIAGMTDVKTQLELSLLGPIRNPELMKAYKVSARGGLLLYGPPGCGKTFIAKAVSGELGASFYQVGIADVLSRWLGESERAIRSVFDTARRKAPCVLFFDEVDALGHRRSALGGSSGLRSVVNALLEEMDSATSTNDGVYVLGATNAPWDVDPALRRPGRFDRMIFVPLPDADARAAIVRLHLQDRPVEGINLATVVKRTDGFSGADLAHMCDSATQLAMADSMRTGQVRPVQMRDVDAALSQIRPSAGAWFDTARNVVDFGNRDGSYDDLAKYLRHRKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGC0</accession>
    <name>A0A132PGC0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854619.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35905"/>
    <dbReference type="EnsemblBacteria" id="KWX21370">
        <property type="protein sequence ID" value="KWX21370"/>
        <property type="gene ID" value="AFM11_25995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3064"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="340" mass="36324" checksum="1E4D4C4223F204E4" modified="2016-06-08" version="1">MTSTTDGAGFVAQAYLDSGNYARAEEVLRSALAADPNNADLLAGLARAKIGQKDYYAAALAAHSALAAAPDSEYTKRLYALALQGQGRLPEALWMAWKTVTEHPDVYLAHYVYASMLYSAGHAQQALVAVNEALRLNPASADSWVLRGDIYRSFWGFAAAEADYHEAIRLEPDHASAVNNLAVSRLRRGKTGMALHGFLGAGRLDPGLGELARRNVGVALTGVLRWTTASVVFMAVALIVVAAMHEEGRATVVPRLFAAALTAGFVAVIVWVFRRVPWPALRAVLRERFLLALRLLFVGFAVLAGLAVTVVGSTPLTDVLGPLLLMGVVGFTVLGWLTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGK1</accession>
    <name>A0A132PGK1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854069.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27165"/>
    <dbReference type="EnsemblBacteria" id="KWX21460">
        <property type="protein sequence ID" value="KWX21460"/>
        <property type="gene ID" value="AFM11_24910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2343"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="478" mass="50042" checksum="6BC519E1A08E7A02" modified="2016-06-08" version="1">MDVTVVGSGPNGLTAAVICARAGLSVRVIEAQSTPGGGARTLPDPEFPGVSHDICSAVHPLALASPFFAAYDLTARGVRLSVPEISYASPLPGRPAVIGYRDIDRTCEELEDGDSWRRLLGPLADDCDGVVGLLLGDKRSVPPSLPAALRVAPRLLVQGTPLWRSLKGEDARALFSGVAAHTISRMPSLVSSGAGLMLATLGHAVGWPIPVGGSQAIPDALIADLKAHGGELVLEQEVTEPPPGVVIYDTAPTALLSIYGDRTPDRYAKSLRRYTYGPGVAKVDFVLSGEIPWEDPRLAHAPTLHLGGSRAQMALAESEIAAGRHAEWPMVLAALPHTADPGRIDSQGRRPLWTYVHVPNGSTADMAETVTTIFERFAPGFRDVVVAVRSVPASNMTEHNANLVGGDIGVGGNNMISALTGPALRVNPWSTPIPKAYLCSSATPPGGGVHGMSGFYAARTVLKREFGIGNLPHLAAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGK8</accession>
    <name>A0A132PGK8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_25850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854549.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36045"/>
    <dbReference type="EnsemblBacteria" id="KWX21347">
        <property type="protein sequence ID" value="KWX21347"/>
        <property type="gene ID" value="AFM11_25850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3034"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="3">
        <location>
            <begin position="10"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="4">
        <location>
            <begin position="284"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="409" mass="42243" checksum="9C99E26F12D679E5" modified="2016-06-08" version="1">MTSASSASQVVICSPIRTPVGRMGGALAALTATDLATITLRELVTRTGLGENDIDDVVLGNGYASGEAPAIGRIAALDAGLGTGVPGLQIDRRCGSGLQAVLYAAGQVATGAARTVVAGGAESMSNVEHYALGLRTGVRQGGIALQDRLDRARETAGGASHPISGGMIETAENLRREYAISREEQDALALRSHQRAVAAHEAGRFADELVPVTVPGKRKPDIVVDRDEHPRADISIEQLASLRPIRGKVDAEATVTAGNASGQNDGAAMCVVTTRAEAEKHGLTPLLMVKSWAVTGCAPETMGIGPVGATAAALDRAGLVLDEIDLIELNEAFAAQVLAVLDRWKVDPLDDRVNPNGSGISLGHPIGATGARILATAAHEAVRRDARYVLETMCIGGGQGLAAIFEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGM4</accession>
    <name>A0A132PGM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854113.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27265"/>
    <dbReference type="EnsemblBacteria" id="KWX21476">
        <property type="protein sequence ID" value="KWX21476"/>
        <property type="gene ID" value="AFM11_25010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2363"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021903">
        <property type="entry name" value="DUF3515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12028">
        <property type="entry name" value="DUF3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="189" mass="19574" checksum="B7560D49CD5235DC" modified="2016-06-08" version="1">MTDPQTTDGPPRALLIAAVVVAVSALITVLGIAASRQQSPDQQPVVISSVPAPQADAAECHALLGALPEQLGDFRRAPTVDPTPPGAAAWRAGAETEPVILRCGLERPGDFVVGAPLQLVDAVQWFQVRDPGAGTEAPEDPRSTWYAVDRPVYVALTLPAGSGPTPIQLISGQITRTMAARPIDPAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGR4</accession>
    <name>A0A132PGR4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymethylenebutenolidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25260</name>
        <name evidence="3" type="ORF">AWC31_27580</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854228.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27580"/>
    <dbReference type="EnsemblBacteria" id="KWX21520">
        <property type="protein sequence ID" value="KWX21520"/>
        <property type="gene ID" value="AFM11_25260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14908">
        <property type="protein sequence ID" value="ORX14908"/>
        <property type="gene ID" value="AWC31_27580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2414"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="13"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX14908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="234" mass="24902" checksum="69FB0412550AA26E" modified="2016-06-08" version="1">MTTISITTPDGPIDALLGTPEDAGPWPGVVVIHDAIGYGPDNESISTRIAAAGYLAITPNLYSRGGRARCITRVFRELLTQRGRALDDILAARDHLLAHPQCTGTVGIVGFCMGGQFALIMGPKGFAASAPFYGTPLPRRLDETLDASCPIVASFGRRDPMGIGAPAKLRKVVQANNIPADIKVYPQAGHSFANQLPAQPLMRITGFGYDEAATADAWSRVFAFFGQHLRPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHJ3</accession>
    <name>A0A132PHJ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853110.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21781">
        <property type="protein sequence ID" value="KWX21781"/>
        <property type="gene ID" value="AFM11_23285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2013"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="113" mass="12228" checksum="D4CB6717D156A791" modified="2016-06-08" version="1">MIENDSGGLIGHIHDETLGDVLVLRKAHLPTMDAAAAAEWLRSQGVAGVATNTLVRARMDGELKATAIGRTYLFSEHDLLTYVESLHGVDRFASRRAATRAHYAARKSQGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHK5</accession>
    <name>A0A132PHK5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_24570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853805.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23550"/>
    <dbReference type="EnsemblBacteria" id="KWX21687">
        <property type="protein sequence ID" value="KWX21687"/>
        <property type="gene ID" value="AFM11_24570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2275"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="222"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="371"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="484"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="591"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="736" mass="77911" checksum="4F2B63644A4E7B7B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHL4</accession>
    <name>A0A132PHL4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853835.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23490"/>
    <dbReference type="EnsemblBacteria" id="KWX21697">
        <property type="protein sequence ID" value="KWX21697"/>
        <property type="gene ID" value="AFM11_24630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2287"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453257" evidence="2">
        <location>
            <begin position="34"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="152" mass="15384" checksum="C007D5A25B6FD192" modified="2016-06-08" version="1">MKINGPIATLGAVAALGTGIFLVNVNQQPEASAPQPAAATAAPAPPSVAPTTPAATPFGAREDFVANIPTKAGNLGLEIRVTGATAKAYACDNKGIETWLSGSAEGGVLKLTSADSTAQLDGRHVGNTVVGNLRIGEKRWDFTAELGETSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI92</accession>
    <name>A0A132PI92_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852679.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08910"/>
    <dbReference type="EnsemblBacteria" id="KWX21907">
        <property type="protein sequence ID" value="KWX21907"/>
        <property type="gene ID" value="AFM11_22300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1810"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="29"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="289" mass="30662" checksum="AC7198AEFDC7C873" modified="2016-06-08" version="1">MAERVVFQSGGSDCVGYLRRVGDRTGPCVVLCTGFGGTQDTPSVVATAEVFAAAGFHAMTFDYRNFGESGGQPRQVVGIEGQLADIAAAVSCARGLDHVDRNRVVLWGTSLGGGHVVTSAARDPAVAAVIAQIPFNGFPKKVEGRSTLSTLKLLGVMAGDWLRGRLGLPPHYIRAVGGPGELAVMTGDGAQRAIAGMTSPTWRNEVAPRGLIEMMRYRPGDFATRVACPLLVCIGTEDAETTPEMAAALAAAAPRGELLEYPVAHFDFYTRDVRDRVVTDQLAFLRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIF7</accession>
    <name>A0A132PIF7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4,5-dihydroxyphthalate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852423.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04560"/>
    <dbReference type="EnsemblBacteria" id="KWX22125">
        <property type="protein sequence ID" value="KWX22125"/>
        <property type="gene ID" value="AFM11_21755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1699"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="328" mass="37065" checksum="F4A3F1804E73746B" modified="2016-06-08" version="1">MARLPLTFACGDYDRTRALEDGSVRADGIELTYLRLPVEETFFRMLRHQEFDVAEMSLSTYVATLDRDPRPFVALPVFTSRMFRHGGIYINADAGISAPSDLRGKRVGAPEFQLTAGVWIRGILAEHHGVPIDSVTYYTGGQESPGRVEKGKVDTGLDIRPIPAGATLAQMLAGGEIDALHTPRVPSPFRDRDPRVKRLFADVVAAEKEYFAATGIFPIMHVVVIRRDVYERHRWVAQSLYKAFLAARDDAYGRIYDSSALRFMEPWLIQHLEDARRLLGPDYWSYGLADNEKTLDVFLRYHHDQGLSRTRYAPVDLFAPETSEAFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIN5</accession>
    <name>A0A132PIN5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MATE family efflux transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Multidrug transporter MatE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_21975</name>
        <name evidence="7" type="ORF">AWC31_04780</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04780"/>
    <dbReference type="EnsemblBacteria" id="KWX22163">
        <property type="protein sequence ID" value="KWX22163"/>
        <property type="gene ID" value="AFM11_21975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10603">
        <property type="protein sequence ID" value="ORX10603"/>
        <property type="gene ID" value="AWC31_04780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1743"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13136">
        <property type="entry name" value="MATE_DinF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PTHR42893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX10603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="444" mass="45848" checksum="3FC0A1AB6D070B86" modified="2016-06-08" version="1">MAEPAGDLPVAPATSRRIAGLALPALGVLAAEPIYLLFDIAIIGRLGAVSLAGLAIGGLILSLVSSQLTFLSYGTTARSARFYGAGDRPAAVGEGVQATWLALALGLAIVIVVQAVAGPLVSVLAAGGDIAEAALPWLRIAILAAPAILVSLAGNGWMRGVQDTVRPLRYVVFGFAVSAVLCPLLVYGWLGLPRMGLPGSAVANLVGQWLAAVLFMWALLAEKVNLRIQPAVLRAQLVMGRDLLLRTMAFQACFVSAGAVAARFGAAAVAAHQVVLQLWSFLALVLDSLAIAAQSLVGAALGAGQLAHAKSVAWRVTVFSALAGVVLAVVFAVGASILPPVFTNDESVLAAIGVPWWFLVAQLPVAGIVFALDGVLLGAGDAKFMRNATLISALIGFLPLIWLSLAFGWGLLGIWSGLSTFMVLRLVFVGWRAFSGRWLVPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ21</accession>
    <name>A0A132PJ21_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_22100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852545.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22187">
        <property type="protein sequence ID" value="KWX22187"/>
        <property type="gene ID" value="AFM11_22100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1768"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="143"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="261"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="413" mass="44872" checksum="76B6D79099455059" modified="2016-06-08" version="1">MIEWSDTDVIMRDTVREFIDKEIRPHLDGLESGELSPYPFARKLFSEFGLDVMAAEAVKTMLDKERERGSGERAQKSGGIGSLGEQASMAAVMVSELAGVSIGLLSTIGVSLGLGAATIMSRGTLAQKERWLPELMTLEKIAAWAITEPDAGSDAFGGMKTYVKRDGSDYILNGQKTFITNGPYADVLIVYAKLDSGDAGADRRDRPVLTFVLDSGMPGLTQGKPFKKMGMMSSPTGELFFDNVRLGPDRLLGETESHSSGDGRDSARANFAAERVGVALMSLGIINECHRLCLDYAKTRTLWGKRIAEFQLIQLKLARMEIARINVQNMVFQTLERLKAGSLPTLSEASAIKLYSSEVATEVAMDAVQLFGGNGYMAEYRVEQLARDAKSLMIYAGSNEVQVTHIAKGLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ26</accession>
    <name>A0A132PJ26_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_20945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852134.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06365"/>
    <dbReference type="EnsemblBacteria" id="KWX22303">
        <property type="protein sequence ID" value="KWX22303"/>
        <property type="gene ID" value="AFM11_20945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1530"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="518" mass="54807" checksum="A01EBD8FBCA6CD3B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ54</accession>
    <name>A0A132PJ54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_21075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852181.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06440"/>
    <dbReference type="EnsemblBacteria" id="KWX22365">
        <property type="protein sequence ID" value="KWX22365"/>
        <property type="gene ID" value="AFM11_21075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1562"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004707">
        <property type="entry name" value="MmpL_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00833">
        <property type="entry name" value="actII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="769"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="794"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="867"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="895"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="56"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="608"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="954" mass="104520" checksum="EDD7E454443E465A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJE3</accession>
    <name>A0A132PJE3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_21795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852438.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04600"/>
    <dbReference type="EnsemblBacteria" id="KWX22132">
        <property type="protein sequence ID" value="KWX22132"/>
        <property type="gene ID" value="AFM11_21795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1707"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="390" mass="42680" checksum="63885E0944B7F43B" modified="2016-06-08" version="1">MLEVQNLVKSFDGERMKRRVRKDRPAGRPGDEAAPVRVFAVNNVSFEVKPGELFTLLGPSGCGKSTTLRSIAGLEQPDSGVVSVGGTTLFAAGADAGKSVNVPANKRGLGMVFQSYAIWPHMTVFDNAAFPLRVRPRKQRPSKHDITERVHRVLETMELLQYADRHATKLSGGQQQRLALARALVVEPALLLLDEPLSNLDAKLRESLRFELKRLQRELGITSIYVTHDQIEALSLSSNIAVMRAGEVVQLGKPRDIYENPQSKFVAEFIGTSNFIDGTVKSRNGDRHVVETRDGRLTLDAAAHMPPGAEVVVSIRPEAVLLSTDRPMDAVNIWEGTVTTRAFLGDAVDHVVSVGKHDIRARCLPHISHAPGSAVYMQMDPAKLALVPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJK0</accession>
    <name>A0A132PJK0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851960.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22516">
        <property type="protein sequence ID" value="KWX22516"/>
        <property type="gene ID" value="AFM11_20440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1422"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="87" mass="9324" checksum="C57466941701453B" modified="2016-06-08" version="1">MKTPACLTWRHPDPARVPCYLLTDRLHEGRMVKVSADQIPAIVAAWLAELGAGSPLVDELARAVWAGNWPTAHAVADQLSVEVAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJT0</accession>
    <name>A0A132PJT0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20775</name>
        <name evidence="4" type="ORF">AWC31_06190</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852073.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06190"/>
    <dbReference type="EnsemblBacteria" id="KWX22272">
        <property type="protein sequence ID" value="KWX22272"/>
        <property type="gene ID" value="AFM11_20775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09804">
        <property type="protein sequence ID" value="ORX09804"/>
        <property type="gene ID" value="AWC31_06190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1494"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="72"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="424" mass="46195" checksum="B4B6CCD45C9BFDD2" modified="2016-06-08" version="1">MNAVGHDHYDDFDRQRLVDEAPKGAALPGTDTEHRTDFARDRARVLHSAALRRLADKTQVVGPRQSETPRTRLTHSLEVAQIGRGMAIGLGCDPDLVDLAGLAHDIGHPPYGHNGERALNEIANAFGGFEGNAQNFRILTRLEPKVLDGDGRSAGLNLTRAALDAVTKYPWQRYGGRKKFGFYDDDLDAAAWMRDGAPAERPCLEAQVMDWADDVAYSVHDVEDGVISGRIDLRVLADADAADSLARLGAESFPTVTHDELLAAAQRLSEMPVVAGVGKYDGTLAASVALKRLTSELVGRFASAAIAETREVAGDGPLKRFDTDLAVPNLVRAEVAVLKMLALQFIMSDHRHLQIQADQRTLIHEVALALWAQAPGSLDPQFEPEFTAADDDGARLRVVIDQIASYTEGRLERVHEARSPRPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJT8</accession>
    <name>A0A132PJT8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851613.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22610">
        <property type="protein sequence ID" value="KWX22610"/>
        <property type="gene ID" value="AFM11_19095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1151"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="621" mass="69030" checksum="DCF9045DC8B376FE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJW8</accession>
    <name>A0A132PJW8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851496.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22400"/>
    <dbReference type="EnsemblBacteria" id="KWX22554">
        <property type="protein sequence ID" value="KWX22554"/>
        <property type="gene ID" value="AFM11_18695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1076"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011340">
        <property type="entry name" value="Cys_dSase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01976">
        <property type="entry name" value="am_tr_V_VC1184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="31"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="398" mass="42071" checksum="0B38D98254EB76B6" modified="2016-06-08" version="1">MAYDVARVRGLHPSLGDGWVHFDAQNGMLVPDSVATTVSTAFRGSMPTTVGPHPSARRSAAVLTAARQAVADLVNGDPRGVVLGADRAHLLTSLAEASSARVGLGYEVVVTRLDDEANIAPWLRAANRYGAKVKWAEVDIETGELPAWQWEGLIDKPTRLVAIASASSTLGTVTDLREVTKLTHEVGGLVVVDHSAAAPYRLLDLDEIDADVVALNAVLWGGPPIGALVFRDPSLIDSFGSVSLNPYATGPARLEMGVHQFGLLGGVVASIEYLSNLDESANGTRRERLAVSMQSAAAYMSRLFEYLLTSLRSLPLVMVIGNPETRVPVLSFAVRDVPAERVVQRLADNGILAISNASSRVLDVIGVNDIGGAVTVGLSHYSTTAEVDQLVRALASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJX6</accession>
    <name>A0A132PJX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15415"/>
    <dbReference type="EnsemblBacteria" id="KWX22650">
        <property type="protein sequence ID" value="KWX22650"/>
        <property type="gene ID" value="AFM11_19330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1199"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="124" mass="13293" checksum="41382FD25BB84533" modified="2016-06-08" version="1">MSFSSRKSSRRFSEEPAMDGIRIHAVDLQDARRRADKQRADAPELPVLLDIEVLIDRDIHAAFAALDGVPSGHALRYIGTPRGLAGLIADVQRLGIADGVVLKPLAGSPVTDLMLEELAPGLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJX9</accession>
    <name>A0A132PJX9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HemS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852173.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06415"/>
    <dbReference type="EnsemblBacteria" id="KWX22322">
        <property type="protein sequence ID" value="KWX22322"/>
        <property type="gene ID" value="AFM11_21050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1557"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007845">
        <property type="entry name" value="HemS/ChuX_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05171">
        <property type="entry name" value="HemS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HemS" evidence="1">
        <location>
            <begin position="156"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="29683" checksum="4A757B6F95CCDE01" modified="2016-06-08" version="1">MCTDGRRCENCPAKRLSAGGGVIARSLPALGTVVAVTANDAALLSHTGEYLAPALPGDALRCGDAYIGLRLHPDLIRDTYLAPRALTLASETGTHRAYFTPLSDELAIRALELAPADEPEPAEAVDWSAVNWSETDQLTHLDTLTPERYQVLPFTGARQVDPRVIPHLLAHLVDMDLPFTIAVPAGGCVQLHRGRAAMFDAAGAHFAVIFGACRYAMDPAYVGECWVTQASGATGLTSAIELYDHSNRCVTVITQTGAVCEHLHEAWEAIAASLPACDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJZ6</accession>
    <name>A0A132PJZ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851739.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15540"/>
    <dbReference type="EnsemblBacteria" id="KWX22670">
        <property type="protein sequence ID" value="KWX22670"/>
        <property type="gene ID" value="AFM11_19455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1224"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="15"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="329" mass="35437" checksum="F88A2491288A055A" modified="2016-06-08" version="1">MSHPWGRPAGEAGAGWAVVDVETTGFRPGQARIVSIAALAVGDDGNVEHSVASLLNPGVDPGPTHVHGLTAEMLEGQPCFGDVVGDVIDVLRGRTLVAHNVGFDYSFLAAEAELVGAELPIDSVMCTVELARRLALGTDNLRLETLAAHWGVSQMKPHDALDDAQVLAQILKPTLARAREHKVWLPLREVSRKRWPNGLITHEELRPLKVLASRLPCPYVNPGPYVPGRPLVQGMRVALSAEVARTHEELIERILHAGLAYSDLVDQQTSLVICNEPTPEQGKGYQAGELGVPLVTDEDFMGLLGHVLGGADVEEFTDTTVDGDQYTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK42</accession>
    <name>A0A132PK42_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851502.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22557">
        <property type="protein sequence ID" value="KWX22557"/>
        <property type="gene ID" value="AFM11_18720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1081"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="221" mass="25237" checksum="A49F47F5C25A540A" modified="2016-06-08" version="1">MSALLYPNTIPDYAVLPDLRLDADERSDLIGNIWEQLVTGNGDVEDFVEVFADDHDLTEEQLTAAFFALRDARLRQQAEIGDYRSRTRAAFDDLNANGVIARADFTCCGTCASAEIGDERDDSRHWRGFVYFHSQDTDRLIEDGATYIGYGAFEPEDFDEDAYNQLSDDAKRDLYFGDVVRMLDEVVFPIVRRHGIEPEWNRDLGTRVLLTNADWYAPIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK96</accession>
    <name>A0A132PK96_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851067.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05045"/>
    <dbReference type="EnsemblBacteria" id="KWX22755">
        <property type="protein sequence ID" value="KWX22755"/>
        <property type="gene ID" value="AFM11_17525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.860"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="488" mass="51397" checksum="1CAD26F65CE41C1E" modified="2016-06-08" version="1">MTPDVVVVGAGPTGLAAACALQEAGVAVRVFDKADGPAVTSRALGLQPRGVEVLDRLGALGDLPEHGLPVERVSVHVDGRPLASLPIGRPARLHGPAALLMSQADIEGALRDRLTELGGTVEWGMPVTGLATEPDGVAVRAGDTDVRCGWVVGADGAHSVVRKAAGIGFPGVPIIERFLLADVHAALDQPRDGATAWARGRKLLAAFPLPGDDLWRLMTPASPDMPDNPAPDDIAGYLGSRLAEEADATIDSVVWTSSFRIQRRLADTYRSGRVLLAGDAAHIHSPFGGQGMNTGIGDAENLAFKLALVVAGRADARLLDTYEAERRPIAGDVLKTTSSLTEIVAGQGRAARLIRDHVAIPLLNRTWMRQLVAEKASQLQVSYRRGPWGASRWSPGIRPGDRVPDHDCVSADGSAVRLYDALGPSWAVLGAPAYADVARDRLGAVVALHDDGSDSSHARLIRPDGHLAWRGSDPAALRAWLDTALGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKK3</accession>
    <name>A0A132PKK3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_18270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851315.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12340"/>
    <dbReference type="EnsemblBacteria" id="KWX22871">
        <property type="protein sequence ID" value="KWX22871"/>
        <property type="gene ID" value="AFM11_18270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1011"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="393" mass="42031" checksum="F033BB21EFAFE2B9" modified="2016-06-08" version="1">MTSSEVVTARLPWDAADPYPFYETCRARGDVVWDDVAHGWLVLGYETARQVLGGEAWTSDPMANPIARANMDPISLQFSGRSMLIADGATHRRLRGSVRDVFTRTFVTGLAEGVDAIASAVIDEPAPDIEFDFMSQIALPIPMGVVAEWLALDPRTADLLAELSPAIIRMLGTLADTDETRAGAAAAAELMGEFLPLAADRRQHPGDDLLSFIAGDPDLELEDVVITAILIAVAGHETTANLLGAGLIRLLTELPDGTRLADHIDAADPAVMTELLRLDSPVQAALRTATEDTRIGDVAIEAGATALIVVAAANRDPQVFDDPDEFRLDRTGPAPLTFGYGAHHCLGASLARLEISTALPKILARRPRLVGGPVWRDTPAIRGALRIPMVFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKN8</accession>
    <name>A0A132PKN8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_17725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11845"/>
    <dbReference type="EnsemblBacteria" id="KWX22915">
        <property type="protein sequence ID" value="KWX22915"/>
        <property type="gene ID" value="AFM11_17725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.900"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="88"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="139" mass="14612" checksum="AED0C3A50D2672F8" modified="2016-06-08" version="1">MPRPARVRPRGERPISRPQQVRPHGAALGHRGTGVLMSRASHRRRPITPATTVLLALVAAAITVWLGLVAQLGGVMGPAESVPTELAVVQVQSGETLQHVAQRIAPDAPVAEVVQQIRDLNELDSAAVEAGQTLIAPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKP1</accession>
    <name>A0A132PKP1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_17640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851412.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05160"/>
    <dbReference type="EnsemblBacteria" id="KWX22911">
        <property type="protein sequence ID" value="KWX22911"/>
        <property type="gene ID" value="AFM11_17640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.883"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="303" mass="32516" checksum="338F99B9651EBA6B" modified="2016-06-08" version="1">MSGSVLFDAPGPRARARNHVLTALTVLITGAVIAFVVYQLWNRDQLEAAKWKPFLTSDLWMTYVLPGVQGTLTAAAVSIVLALALGLILGVGRLAPIGPIRWVSAVIVEFFRAVPVLIMMIFAYFLYATYDVFPSKHLALAGVITGLTLYNGAVIAEIVRAGVSSLPRGQSEAAWSLGLSWTQTMRMILLPQAITAMLPVLISQLVVVLKDTAIGYQITFVEMVRQGTNIGSSYGNYLPALIVIAILMITVNFALSALATNIERRLRSSRRAPTPLAAEAIEQEGAPGAHVELAATGEQSRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKX4</accession>
    <name>A0A132PKX4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_16670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850710.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01240"/>
    <dbReference type="EnsemblBacteria" id="KWX23005">
        <property type="protein sequence ID" value="KWX23005"/>
        <property type="gene ID" value="AFM11_16670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.684"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="16"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="405" mass="42426" checksum="B9C1C025BBDDD93A" modified="2016-06-08" version="1">MSTATTPYTGRRQSVNLVLATWVSAINFWAWNMIGPLSTTYAGDMRLSSTEASMLVATPILVGSLGRIVIGSLTDRFGGRTMFIAVSLASIPPVVAVGLAAEAGSYPLLLVFGFFLGIAGTIFAVGIPFSNNWYEPSRRGFATGVFGMGMVGTALSAFFTPRFVNWFGLMATHIIVAAALALTAVLCIAVMKDAPAFVPNTDPVLPKLKAAAKLAVTWEMSFLYAVVFGGFVAFSNYLPTYIKTVYDFPAVEAGARTAAFALAAVLARPIGGALSDRIPPKYVVLVSFAGTALMAFVAVFEPPPDVWSAATFITLAIFLGIGTGGVFAWVARRAPAKSVGSVTGIVAAAGGLGGYFPPLVMGATYDRVGNDYTVGLLLLVATALVALAYTALRLHAHEPVKEPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL22</accession>
    <name>A0A132PL22_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MLTR_LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850782.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23038">
        <property type="protein sequence ID" value="KWX23038"/>
        <property type="gene ID" value="AFM11_16860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.725"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="1">
        <location>
            <begin position="107"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="31969" checksum="F92B35FC337FA7E9" modified="2016-06-08" version="1">MTSADGDLADVARLLRARRRVLQPEDVGLPRGRRRRTPGLRRDEVAALCSVSSAYYGRLERPCGPRPSPAMLASIARGLRFNRADRDRLFSAAGYDLAREVLGTAHVDPGVMHVLGRLADTPAMVVDAVGEVLHQTPSAKVLFGELTGFSGWSRSGYYRWFTDPGERLRHGVTEHSTIGDEIVADLRRSLMDRENTCPASDLVKLLLRRSDEFAEIWRRAPLVDAVRINRQCRIVHPALGVIQLQREVLVDTDRNRRVVIYLAVPGSENHTKLKLSTVIGHHRFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL51</accession>
    <name>A0A132PL51_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850838.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01600"/>
    <dbReference type="EnsemblBacteria" id="KWX23068">
        <property type="protein sequence ID" value="KWX23068"/>
        <property type="gene ID" value="AFM11_17030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.759"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="132" mass="14388" checksum="A83B708E521381A4" modified="2016-06-08" version="1">MVDPGHVFRRAFSWLPAQFASQSDAPVGAPRQFGSTEHLSIEAIAAFVDGELRMSAHLRAAHHLSLCPECAAEVDAQSQARAALRDSCPIAIPNSLLGMLSQIPHHIPQPPPEVPDKAQFAEDPARGRRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLA0</accession>
    <name>A0A132PLA0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850953.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01915"/>
    <dbReference type="EnsemblBacteria" id="KWX23121">
        <property type="protein sequence ID" value="KWX23121"/>
        <property type="gene ID" value="AFM11_17335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.820"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="114"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="427" mass="45968" checksum="416ABE35A3CE5412" modified="2016-06-08" version="1">MAGSSVPEPAVAPGDDPRRYAMLLSEVYDATMSGARAPARPRALIADSWNRLLGKGIHPEHHSPPDIDTSGLDMLRQSSGLLTVLDDVSRGLESVIEEGDNILVMADARGRVLWRSGSPRVLNFADRLGFIEGASWSESSVGTNGIGTALASHRAVQIFSAEHFLRSHHPWTCAGAPIRDPRTGHVIGIVDVSGPAATVHPTTVALVDLVARLAESKLREAHDRTLNRLRTVSAPILARMGSPALAVDPHGWVAAVDSLPLHNRILLPENGMPGRVWIPPLGMCDVESLPDGWLVRVTSDAESSPMVSRVTLDLRDGNEPSLEMVGQFGSWRRGISTRHAEILLVLATCPQGRSAPELAEDLYGDRSRVVTVRAEMSRLRKQFVGLVAGKPYRFGDSVAVDVRYPQDLSTLLTSSTAPAVRAARGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLI9</accession>
    <name>A0A132PLI9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850119.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15760"/>
    <dbReference type="EnsemblBacteria" id="KWX23163">
        <property type="protein sequence ID" value="KWX23163"/>
        <property type="gene ID" value="AFM11_15140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7140"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="112"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="246" mass="26667" checksum="3B73103CA578D11E" modified="2016-06-08" version="1">MSTPFTPQPGGFGFGFGPGFGPGDRRAMHHQRRAARREMRDQMRAHLHEAREQALDPRCETGFGGPGFGPGRGFEFGFDPRGGFGFGFGGPRGGRRGGRGGRGRRGDVRAAILTLLAERPMHGYEMTQEIAARSNNLWKPSPGSVYPTLQLLVDEGLIVPAESEGSKKTFELTDEGRAAAEKIATAPWDEIVEDADPNAVNLRGAVAQLMGAVAQSAHTANEDQQQRILDAVNNARREIYQILGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLK4</accession>
    <name>A0A132PLK4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851370.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12580"/>
    <dbReference type="EnsemblBacteria" id="KWX22892">
        <property type="protein sequence ID" value="KWX22892"/>
        <property type="gene ID" value="AFM11_18555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1046"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="32730" checksum="71BBF056EFCA453D" modified="2016-06-08" version="1">MLDLRRMMLLSDLADLGSVTAVAERRNITSSAVSQQLRVLEEEAGAVLFRRDGRTLGLTRSGQVLAEHVRRVLVAVDEAMSAVAATSDRVAGQVAIATFNMGIPTLAVPLMQRLSGEAPDLRVQVQQESSSAAIRLLRQGEVDVAITCQYDFVGQDSPGGLNTVPLLFEPLVLLAPTHTHLRIRKQGLAALADGPWVTGPQNSGLGVAVMRAGESAGFTPQVKHRLIGAQNICDLAATEVASAIVPRLSVPAKLAALIVPGLDLGGRTISAVVRAGRQRDPNISLILRTLRAIADEALPVQSDEALSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLS4</accession>
    <name>A0A132PLS4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NDP-hexose 4-ketoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_15940</name>
        <name evidence="10" type="ORF">AWC31_16515</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850405.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16515"/>
    <dbReference type="EnsemblBacteria" id="KWX23300">
        <property type="protein sequence ID" value="KWX23300"/>
        <property type="gene ID" value="AFM11_15940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18004">
        <property type="protein sequence ID" value="ORX18004"/>
        <property type="gene ID" value="AWC31_16515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7313"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="425"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="808"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX18004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="849" mass="93612" checksum="2DE92249F0AB6F79" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLV7</accession>
    <name>A0A132PLV7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16735"/>
    <dbReference type="EnsemblBacteria" id="KWX23335">
        <property type="protein sequence ID" value="KWX23335"/>
        <property type="gene ID" value="AFM11_16130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7351"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="226" mass="24216" checksum="5C120C4AE661CA29" modified="2016-06-08" version="1">MTFGYNRTQVFTDLTVEFAGGATTAIAGPNGSGKSTLLGLIAGLLHPQHGTVDLAGADDIALAVQRDQVAQTFPITVGEVVAMGRWRRLGLLRRPTRADRDIVDYWIDELALDGLRHRRLGELSGGQRQRTLLAQTFAQQAPILLLDEPTAGLDADSAETVYRHLQRLAASGTTVVAATHDPDAHARFDHHIDLTAFAAAIGSSCASTCLQPRRTAGRLPGHNRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLX0</accession>
    <name>A0A132PLX0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850504.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16805"/>
    <dbReference type="EnsemblBacteria" id="KWX23348">
        <property type="protein sequence ID" value="KWX23348"/>
        <property type="gene ID" value="AFM11_16200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7365"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453388" evidence="1">
        <location>
            <begin position="26"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="190" mass="20059" checksum="16496F74378F144D" modified="2016-06-08" version="1">MKRILGVLAVSAASAALTAPAVANAAVNTAVTSIPTPNGILEMHATADCAGDRCRFNTQANLLGPNGPIGLPGDTWARQTITLRSTDRSVWQEASYSAPSGSPRELHKGANNNNVLSRMLKATNNVEISVTYFGGGGLERFRVDGDSQPIDWRTGQPDREADFIACTQIQVVSSGWNLTTPTACAQTNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM40</accession>
    <name>A0A132PM40_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_14045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849690.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09425"/>
    <dbReference type="EnsemblBacteria" id="KWX23411">
        <property type="protein sequence ID" value="KWX23411"/>
        <property type="gene ID" value="AFM11_14045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6913"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="28"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="259" mass="27750" checksum="B0AA593A53F399A9" modified="2016-06-08" version="1">MSVFVDIVPSESHTDSRPAATPGRWRALLTKAVLPLLSVVVFFVVWQLVALAGIWNQTFVPYPSTVWRAFLDVSTTHDGVRGYGGYLLVEHLYMTLRRVLEPWLTFLRALPPLAYFFLLVIWLGIDEAPKITLLALAALPPAAVATTAAVVAAPVGLQEAARALGASRAQVIRDVVVPSALPETFTGIRLAVGMAYSSVVAAELFNGIPGIGGLVKDASNYNNTPVVLVGIFAIGISGLVIDGALRAVERRAVPWRGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMC8</accession>
    <name>A0A132PMC8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell wall synthesis protein CwsA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cell wall synthesis and cell shape protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cwsA</name>
        <name evidence="3" type="ORF">AFM11_14515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for regulated cell division, cell wall synthesis and the maintenance of cell shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Localizes to poles and midcell sites.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CwsA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849849.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18310"/>
    <dbReference type="EnsemblBacteria" id="KWX23489">
        <property type="protein sequence ID" value="KWX23489"/>
        <property type="gene ID" value="AFM11_14515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7011"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00927">
        <property type="entry name" value="CwsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024245">
        <property type="entry name" value="CwsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10814">
        <property type="entry name" value="CwsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="130" mass="13657" checksum="8A0E7CB3E6C5B8B4" modified="2016-06-08" version="1">MTANADLRLAPHQRLSRGLKYTAVGPVDITRGVVGLGLNSAQATANGLRRRYESGKLRRQLAAAAEAVAALPEVIQEATAPPRKRRRPLVIAGVAAAVLAGGAVVFSIVRRSTRPEPSPLPPSVEVTPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMD2</accession>
    <name>A0A132PMD2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23498">
        <property type="protein sequence ID" value="KWX23498"/>
        <property type="gene ID" value="AFM11_14570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7024"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="81" mass="8263" checksum="B7833363CA3CF7E3" modified="2016-06-08" version="1">MSSSLGGAVLTGGAQAVDFAVGGGQLSTNPTIDPSYAYSVNCGGQLRKAGLVSSDRRSVNVFHRVTQTPASTVRGARPKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMK2</accession>
    <name>A0A132PMK2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850014.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17890"/>
    <dbReference type="EnsemblBacteria" id="KWX23566">
        <property type="protein sequence ID" value="KWX23566"/>
        <property type="gene ID" value="AFM11_15015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7114"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="282" mass="31442" checksum="F0BE08099BE79957" modified="2016-06-08" version="1">MVDVRNLTVVVDGLRSPVIEAGDPDGREAVVYVHGSPGCGGEFTKLVCETGKFVRAIAPDIPGFGQADKPHPRHFIYDVPNIGVHLVKQLDALGVERAHFVGHDFGGSWAMFASLYDPMRVGSLSLINAGLMRGMRWHGMARLYRTPLAGEAFMAIANEWGFKRALQGLPTADLEVMWRNFDRHSRRAILALYRATDMETQTAQLPQVRLFTTQWQSIVIFGADDPYLPTKFADRNRESLPNASVHMIDGAGHWPHLQAPERLSELLIPFLREQVTTDRATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN18</accession>
    <name>A0A132PN18_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cro/Cl family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_13165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849262.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03450"/>
    <dbReference type="EnsemblBacteria" id="KWX23731">
        <property type="protein sequence ID" value="KWX23731"/>
        <property type="gene ID" value="AFM11_13165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6726"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026281">
        <property type="entry name" value="HTH_RamB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018653">
        <property type="entry name" value="ScfR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12844">
        <property type="entry name" value="HTH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09856">
        <property type="entry name" value="ScfRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019251">
        <property type="entry name" value="Rv0465c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="471" mass="53027" checksum="FD376C0E73D76185" modified="2016-06-08" version="1">MAKTFVGSRVRQLRSERGFSQAALAQMLEISPSYLNQIEHDVRPLTVAVLLRITEVFGVDATFFASQDDTRLVAELREVTMDRDFGVDVELSEIADMVSAHPNLARAMVNLHRRYRLTTTQLAAATEDRYSDGSGSGSITMPHEEVRDYFYQRQNYLHELDTAAEDLTARIRMHRGDLAGELSNRLTTVHNVRIVRRIDLGDTVLHRYDPATKTLEMGNHLSRGQQVFKMAAELAYLEFGDLIDKLVDEGMFTSDESRTLARLGLANYFAAATVLPYRQFHDVAENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVPFSFVRVDRAGNMSKRQSATGFHFSSSGGTCPLWNVYETFSNPGKIGVQIAQMPDGRNYMWVARTVERRASRYGQPGKTFAIGLGCELRHAHRLVYSEGLDLSGEVATPIGSGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN81</accession>
    <name>A0A132PN81_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12705</name>
        <name evidence="2" type="ORF">AWC31_03025</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849036.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03025"/>
    <dbReference type="EnsemblBacteria" id="KWX23657">
        <property type="protein sequence ID" value="KWX23657"/>
        <property type="gene ID" value="AFM11_12705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11119">
        <property type="protein sequence ID" value="ORX11119"/>
        <property type="gene ID" value="AWC31_03025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6631"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="71" mass="7536" checksum="9B84C03E122F47EC" modified="2016-06-08" version="1">MKDQLSKTEIGKDVLQESVEAVASTVGEVATIITTAVKDVASAIGGLATDVFEIRDSARKAREAQLEDETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNG7</accession>
    <name>A0A132PNG7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_13405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849613.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03690"/>
    <dbReference type="EnsemblBacteria" id="KWX23886">
        <property type="protein sequence ID" value="KWX23886"/>
        <property type="gene ID" value="AFM11_13405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6775"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="162" mass="17868" checksum="8D5AD29F3AA02175" modified="2016-06-08" version="1">MNWGATADERTATLPCDALAPTARTRADRAITIHAPIPIVFAWLCQLRAAPYSYDLLDNFGRRSPRTRNPELTRLAAGQRFMGTFELHSFAADQHITLRAGRVTVTYALRAVGAGSRLHVRVLFDGPRPIGWALAVGDLVMMRKQLLTLRELAEQEAATIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNL7</accession>
    <name>A0A132PNL7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23864">
        <property type="protein sequence ID" value="KWX23864"/>
        <property type="gene ID" value="AFM11_12845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6662"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="6"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="477" mass="49342" checksum="C9CFFDD53F990A0D" modified="2016-06-08" version="1">MIGGEWVEGDGAAAATINPADDTAVAVYHPADSRHVDAAITAAVAARREWDEMGIIARGLILRRSAEILADRAETVAVLMTREQGKTLPESRAEVGATVETLHYHAAQARSADGVTYPSSHPDELIRTVRRPLGVVAAITPWNFPLQIPAWKLAPALLWGNTVVWKPASDTVAVAAAFAAILVDAGIPAGVLNMILGPGSIGAELVAHESVSGVTFTGSVPVGRSIQAATVPRGAKVQMELGGHNAAIVMPDSDPAQAAAVLVGAAMGSTGQKCTATRRIIAVGEAYDDLVAELTALVGALSVGDGSDPATQIGPLVSARAAKEVAAAVEQALEEGAELLARAPLPDSGGAYVAPTLLAGTPALTVCREEVFGPVVTVLRAENLDEAIDIANSTPFGLTAAVFTDDEHVVRRCIRELEAGLVKVNAPNTGSELHAPFGGLKDSSFPAPREQNAASSADFFTWSKTAYVRPGAPRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNR7</accession>
    <name>A0A132PNR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin biosynthesis protein CbiX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848121.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30660"/>
    <dbReference type="EnsemblBacteria" id="KWX23943">
        <property type="protein sequence ID" value="KWX23943"/>
        <property type="gene ID" value="AFM11_11235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6324"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="240" mass="24543" checksum="4D9DAE901DE0A206" modified="2016-06-08" version="1">MSLVLVAHGTRKPGGVAMIGDLADRVAGLLDRRVHVSFVDVLGPTPAEVLATLPTDRPAVLVPAFLAAGYHVRVDVPAQVAASGHPLVSVTPPLGPCLGTVRVIADRLVESGWRPGDAVILAAAGTSDPSAQSDLRRTAAMLSAVTGDRVELAYAATGAPSVADAVAAQRCRSGGDSICSSRPRRVVVASYLLADGLFQDRLGASGADLVSDPLGTHPGMVRLIANRFRRAGVLSLPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNY4</accession>
    <name>A0A132PNY4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848258.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23984">
        <property type="protein sequence ID" value="KWX23984"/>
        <property type="gene ID" value="AFM11_11480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6372"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041674">
        <property type="entry name" value="TetR_C_22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17928">
        <property type="entry name" value="TetR_C_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="187" mass="21340" checksum="2B5576D93761DEAB" modified="2016-06-08" version="1">MIQSILDTATELVIDVGYEAVVSSPTLLLDRSGVSRGSFYSFFESPERVLDELAYQGVQQSIESFDKALAAIPRKHWTEVIDVLIDQYTVEHRAPLVRELWVRQNLTQRARELDHLAIADMAVLMLAAFRTFGRVFDTLTELQCRVAIHAVERLFQYAFIDEPNGDPLIIAEAKRMLIDYFAGYSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP08</accession>
    <name>A0A132PP08_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848523.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10015"/>
    <dbReference type="EnsemblBacteria" id="KWX24070">
        <property type="protein sequence ID" value="KWX24070"/>
        <property type="gene ID" value="AFM11_11960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6472"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="75"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="298" mass="31683" checksum="DA04AD202FDEF41A" modified="2016-06-08" version="1">MTSATETAAFHPDLERIARFIPRQLVTRHTLPIFQRLTGLQGRRTPKDVEVLTLTSGAGVRLFRPAGRATPGPALLWMHGGGYVLGSPAQDDALCRRFANELGATVAAVKYRLAPQNPYPAALEDCYSALTWLAALPTVDPARVAIGGASAGGGLAAALAILARDRGVPLAGQLLVYPMLDDRSTGPELDSPGHRLWTQGSNKFGWAAYLGDADPALAVPARHEDLSGLAPAWIGVGTLDLFHDEDLAYAERLRAAGVPCEVEVVDGAFHGFDQIAPKTPVSRDFLASQFTNLRAAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPH5</accession>
    <name>A0A132PPH5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="9" type="ORF">AFM11_09400</name>
        <name evidence="10" type="ORF">AWC31_05825</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847077.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05825"/>
    <dbReference type="EnsemblBacteria" id="KWX24205">
        <property type="protein sequence ID" value="KWX24205"/>
        <property type="gene ID" value="AFM11_09400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09743">
        <property type="protein sequence ID" value="ORX09743"/>
        <property type="gene ID" value="AWC31_05825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5917"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX09743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="86" mass="9515" checksum="01E13A5D8AD80A01" modified="2016-06-08" version="1">MANIKSQEKRIRTNERRRLRNQSVKSSLRTSVRGFREAVEAGDKEKAAELLVSTSRKLDKAASKGVIHANQAANKKSALALALNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPL1</accession>
    <name>A0A132PPL1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-deoxyglucuronate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847281.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05455"/>
    <dbReference type="EnsemblBacteria" id="KWX24271">
        <property type="protein sequence ID" value="KWX24271"/>
        <property type="gene ID" value="AFM11_09770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5992"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024203">
        <property type="entry name" value="Deoxy-glucuronate_isom_IolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39193">
        <property type="entry name" value="PTHR39193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036628">
        <property type="entry name" value="IolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04378">
        <property type="entry name" value="myo_inos_iolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="290" mass="31586" checksum="43B9592062B6604A" modified="2016-06-08" version="1">MHSKLYIPARSAELPFTVDVTPESAGWTESSLRVLELDDSQTAELHTGRTEVMILPLTGGGTVSCGGETFELSPRASVFDGPADMVYVGIDQEYVLSGGGRFAICGARAKRSFPNRRVAAADVALELRGAGNCSRQVHNFGTADTFEADSLIACEVITPGGNWSSYPAHKHDENTPTQTALEEIYYFEIAEGPDGSRGFGYHRVYGTPDRPIEVLEEVRTGDVVLVPHGYHGPSVAAPGYHMYYLNVMAGPGAERAWKIVDDPEHTWLRGTWDGQDIDPRLPLHQPRKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ71</accession>
    <name>A0A132PQ71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_09850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05375"/>
    <dbReference type="EnsemblBacteria" id="KWX24481">
        <property type="protein sequence ID" value="KWX24481"/>
        <property type="gene ID" value="AFM11_09850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6008"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="459" mass="48581" checksum="6188D17A949EB3F5" modified="2016-06-08" version="1">MSAALDRIGFGRVQTVVILLLMAGLFFDSLEQNSTGAMGPLLKESFGIGNAELTMINTATVVGGLVGRLIGGYIADRWGRRTALSLNLLIYTLGGLVSAAAVNYEMLLASRFVVGIGLGGEFTVGLAILAEIVATRHRGTLLATLNISSGGIGNIASFGFFWLVLGPLNGALGGNDSAWRWTYVILAVPAVLVVFFRRYLPESPRYLLSQGRVDDANRSLTRLASGSIAGLRNPGATKQFVTVEDIPVQTKSSYVEVFKGQNLRRTAAIGAASWMSFGAQVTLLFLMPILLVSRGYSLQDSLAFTMIMNIGSLFGACAASYLAGKAPRRLTVTCAAILGCISAISFAAFATSTTLILVLGMIFQFFTMMLNTMLSVWSPELFPTSVRAMGASVVNGIGNVAGAVMPFAALFFFDRAGVPGVFIMIAIMYALLVVAARFGPETFGKSLEAVSEKPVPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQE3</accession>
    <name>A0A132PQE3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MorD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846031.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22105"/>
    <dbReference type="EnsemblBacteria" id="KWX24543">
        <property type="protein sequence ID" value="KWX24543"/>
        <property type="gene ID" value="AFM11_07605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5370"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="325"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="509" mass="56511" checksum="9B8DA2216DCC98AA" modified="2016-06-08" version="1">MSELSDTHAMATERSCAVTAVALSGQRRTGARLVSGQHRGFGLSSLLDVVHVPYPPHRDWTRRTLTCGVALQCSPSKERVVDYRLNELSTRELAALTLIEAGVALGWVAENWPGLLADLHANLPDLEPARADMDAAEMLNRAITLARTAQQLPLDPLLGSLPRAYTLPQGLSDKMRRAFGRLPWTSTQKRLPRAHSVPVGGDGGVRNPNLPPPSRPQDNDLDITPDHRPGIPYPEWNAWTKSFMPDHVAVLEQTYTQRHRQPGVIAVDVRKWFEENTHRAMKNRLEDGSDLDVDRYVDHYIDLTTGEAVEPRLFRELLPASRDVTTALLLDGSSSLGVHGGRIFKLELACADALSRAMTSARERHGIFTFTGNTRHRVEVRCLKDFEERRFVPPGSLGLSTGGYTRLGAPLRHMTSRLLAQPSERRLLIVIGDGLISDEGYEGRYAWADAAHAVEEANEAGVAMYYVGVGPTRVDPLPEVFGPKRSQRIRRVEELPRVLAHVHRELVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQL1</accession>
    <name>A0A132PQL1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846235.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24610"/>
    <dbReference type="EnsemblBacteria" id="KWX24616">
        <property type="protein sequence ID" value="KWX24616"/>
        <property type="gene ID" value="AFM11_08010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5452"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="123"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="273" mass="29138" checksum="B2E3707132FAD83C" modified="2016-06-08" version="1">MSALHVIDIEDPADPRIDDFRDLNSVDRRPDLPTGKGLVIAEGVLVVQRMLASRFVPRALLGTDRRLGELAADLDGVDVPFYRASAEVMATAVGFHLNRGVLASASRPPELAVEQIVSGAHTVAVLEGVNDHENLGSIFRNAAGLAVDAVVFGAGCADPLYRRAVRVSMGHALLVPFARAASWPDDLELLRTKGFRLLAMTPDASAATLSDAMARLEKGRVAILVGAEGPGLTERTMRASDVRVRIPMSRGTDSLNVATAAALAFYERSRLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQS7</accession>
    <name>A0A132PQS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_08450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846459.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00305"/>
    <dbReference type="EnsemblBacteria" id="KWX24689">
        <property type="protein sequence ID" value="KWX24689"/>
        <property type="gene ID" value="AFM11_08450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5538"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="194" mass="21625" checksum="D3186F0DD4A28A22" modified="2016-06-08" version="1">MPSGQRRGRWSGVPLRERTALRRDELIAAGVKLLGDAEGPALTVRAVCREAELTERYFYESFTDRDGFVRAVYDDVCARAMSALTSAATPREAVERFVALMVDDPARGRVLLLAPESEPVLTRSGAEWMPNFIDLLQRKLTRIADPVRQAMVATSLIGALTALFTAYLNDRLPATREQFIDYCVDMLLGRVPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQZ5</accession>
    <name>A0A132PQZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08655</name>
        <name evidence="2" type="ORF">AWC31_13715</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846554.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13715"/>
    <dbReference type="EnsemblBacteria" id="KWX24725">
        <property type="protein sequence ID" value="KWX24725"/>
        <property type="gene ID" value="AFM11_08655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18367">
        <property type="protein sequence ID" value="ORX18367"/>
        <property type="gene ID" value="AWC31_13715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5581"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="76" mass="8638" checksum="EBA0AAEF741FD1F9" modified="2016-06-08" version="1">MSATTETGHVTGTKDKNYNLIWYTEQCLENALRMETFIADAERDGDNEVVELFRKAQADSRKGAEMAKHMLASRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRG5</accession>
    <name>A0A132PRG5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="10">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alaS</name>
        <name evidence="13" type="ORF">AFM11_05750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845088.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11610"/>
    <dbReference type="EnsemblBacteria" id="KWX24941">
        <property type="protein sequence ID" value="KWX24941"/>
        <property type="gene ID" value="AFM11_05750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4341"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="1"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="580"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="683"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="687"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX24941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="896" mass="96417" checksum="7B4D6EAC3B2E2C15" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRS4</accession>
    <name>A0A132PRS4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SgcQ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06310</name>
        <name evidence="3" type="ORF">AWC31_29365</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845262.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29365"/>
    <dbReference type="EnsemblBacteria" id="KWX25039">
        <property type="protein sequence ID" value="KWX25039"/>
        <property type="gene ID" value="AFM11_06310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13884">
        <property type="protein sequence ID" value="ORX13884"/>
        <property type="gene ID" value="AWC31_29365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4456"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="PTHR21381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005956">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00259">
        <property type="entry name" value="thylakoid_BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="271" mass="28761" checksum="209F57D47283E814" modified="2016-06-08" version="1">MTSWLDEVFAVRKPVIAMLHLAALPGDPGFDSAAGIRAVVDRARGELAALQEGGVDGVMISNEFSLPYLTQTEPITAITMARVIGELLPDFSVPYGVNVLWDGRASIDLAVATGAQWVREIFTGVYASDFGLWDTNVGAVARHRHRIGGDGVKLLFNIVPESAVYLADRDLASVTATTVFATRPDAICVSGLTAGASTDSQALQVVKNAAGAVPVFVNTGVRAHNAPDQLSIADGAIVGTYFKEDGVFENRAVASRVTELMNVVKDFRKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRT9</accession>
    <name>A0A132PRT9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LemA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_05995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845164.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29665"/>
    <dbReference type="EnsemblBacteria" id="KWX24984">
        <property type="protein sequence ID" value="KWX24984"/>
        <property type="gene ID" value="AFM11_05995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4390"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453237" evidence="6">
        <location>
            <begin position="30"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="179" mass="19407" checksum="051144967AF41C86" modified="2016-06-08" version="1">MVTLALIVILILAVSVLIGFVVGHNKLRAADVNVAEALAGIDVELSRRAALIPALVHTVQTFAAHEKAVLGQVSAATAALTRATGSTSVARRCAAETELDDAIAEVLALRSAYPQLNSSNNFLDLQDDLADTENKLAFARQYYNDAVSQLNRLIATIPWMYVARLAGVEERDFYQMPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS06</accession>
    <name>A0A132PS06_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06390</name>
        <name evidence="3" type="ORF">AWC31_29285</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845290.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25054">
        <property type="protein sequence ID" value="KWX25054"/>
        <property type="gene ID" value="AFM11_06390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13871">
        <property type="protein sequence ID" value="ORX13871"/>
        <property type="gene ID" value="AWC31_29285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4472"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="159" mass="17943" checksum="0506936E1F898DF2" modified="2016-06-08" version="1">MKELTVDVYNADYRVLYRIPWQDAVQLILRDAVYIIDTHDPAVHIHSPSLVIELPMSVALREYVHIPYRPTDRATRVGVLRRDRHTCVYCGGRADTVDHVLPRSRGGSDHWLNLVAACQPCNGRKGDRTPGEAGMSMMREPFEPKQPDVFGQAPVLVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS99</accession>
    <name>A0A132PS99_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_06490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845325.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29185"/>
    <dbReference type="EnsemblBacteria" id="KWX25067">
        <property type="protein sequence ID" value="KWX25067"/>
        <property type="gene ID" value="AFM11_06490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4491"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="336"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="263"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="542" mass="58352" checksum="E4E4D3DD1DFC71DF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSF8</accession>
    <name>A0A132PSF8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845463.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28830"/>
    <dbReference type="EnsemblBacteria" id="KWX25127">
        <property type="protein sequence ID" value="KWX25127"/>
        <property type="gene ID" value="AFM11_06820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4563"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="174"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="272" mass="30044" checksum="55EEF85B09349193" modified="2016-06-08" version="1">MRYTRHIPAVALRDSVDHLWCIADGPRHSAERILPTGTTELVVNLGADTIAVTNNQGCQRFSGTVLAGPYTTPFDIDARMHTAMVGVHFKPGGARTVLGFSPPDLLDSHVDLHALWNGAADTIRAELCEAGSDAERFAILESALLALPANRTTLTPEVAFTVDALGYGTPHPPIAALAREVGFSHRRLVQLFTQQVGVPPKRFARVRRFRHAHHHVMSAQSLPHWPGFALAHGYADQSHMIREFRRFSGLTPVQHFRGRNLMSKDDHLALRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT57</accession>
    <name>A0A132PT57_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25503">
        <property type="protein sequence ID" value="KWX25503"/>
        <property type="gene ID" value="AFM11_04470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2772"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="60" mass="6930" checksum="B96ED077FFD76BA6" modified="2016-06-08" version="1">MEFDTQRQRALADRVGPAIQVPATNNETARLRSVKAQVKEKTNVDLRDDVVLAWLRRREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT82</accession>
    <name>A0A132PT82_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutamine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_04590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844558.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20555"/>
    <dbReference type="EnsemblBacteria" id="KWX25523">
        <property type="protein sequence ID" value="KWX25523"/>
        <property type="gene ID" value="AFM11_04590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2797"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453575" evidence="8">
        <location>
            <begin position="20"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="268"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="466" mass="50793" checksum="458989C1D0F57146" modified="2016-06-08" version="1">MVFVGLFGTALLAPATASAEGETYVIATDITFAPFEFQDASGKFVGIDIDLINEIAADQKFNVTIKPLGFDAALQAVQANQADGVIAGMSITDERKKVFDFSDPYFESGVQMAVLATNEDIKSYEDLRGKRVAVKNGTEGAEFAESIKDKYGFTTVYFADSASMFDEVRTGNSQAVFEDYPVLQYGIAQGNGFKTVTPKEKGASYGFAVNKGQNGELLQKFNAGLASLKDSGRYDEILETYLGEDAVETDNSFFGLLKSTFPILMVGLKMTIILTVVSIAIALVLGIIFGLFRVSRNIVLRAIGTTYVDIFRGTPLLVQAFFIYFGIPSALGFQMSALTAGIITLSLNAGAYMTEIVRGGIQSVDKGQMEASRSLGIGYLPTMRKVILPQAIRTMIPSYINQFVITLKDTSILSVIGIAELTQTGRIIIARNFQSFEMWLIIGIIYFIVIMALTKLSDRVEKRLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTB2</accession>
    <name>A0A132PTB2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_03015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843808.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25282">
        <property type="protein sequence ID" value="KWX25282"/>
        <property type="gene ID" value="AFM11_03015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2471"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="3">
        <location>
            <begin position="448"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="526" mass="57774" checksum="204F2B50498AC616" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTD5</accession>
    <name>A0A132PTD5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844708.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25596">
        <property type="protein sequence ID" value="KWX25596"/>
        <property type="gene ID" value="AFM11_05010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2883"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="407" mass="44002" checksum="505553C8FB8071B7" modified="2016-06-08" version="1">MSAPSGILSGYRVLDCSIAMAGPFAAQRLGDLGADVIKVEPTSGEWQRHAPAGGAVGNEINVSFLSLNRNKRSLAVDLKHPEGKQLLRELVASADVFLQNYRPGVADRLGVDYETLREINPALVYVSISGYGEDGPYAQRPGQDLLLQAMSGAMLSSGRAGDPPQAAGQYLVDAVTASTAFEGVLAALLHRERTGEGQKVTVNMLDAIVTLQMQELSVFAQGGVPQERSDQPHGHVYIRSPYGTFATTDGFLALSMPDLPTLAELLDEPLIADDTAWPQSAAERDRVFALTANRLRTRSTEEWLALFEPADIWCAPVYGYADVLADPQIIHNETFVHYQHPTEGSVVTPGFPYGFSKTPAKIRFGAPMVGEHSREVLAEMGIDADRIETLIDAGAVADRTSIKERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTJ4</accession>
    <name>A0A132PTJ4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_05285</name>
        <name evidence="9" type="ORF">AWC31_20055</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844801.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20055"/>
    <dbReference type="EnsemblBacteria" id="KWX25640">
        <property type="protein sequence ID" value="KWX25640"/>
        <property type="gene ID" value="AFM11_05285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16354">
        <property type="protein sequence ID" value="ORX16354"/>
        <property type="gene ID" value="AWC31_20055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2942"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="108"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX16354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="176" mass="20173" checksum="87CA8C4E174BAA78" modified="2016-06-08" version="1">MLTVEQPTDQMLELYANHVEPLRRYAFRLTSNRTKAEDVVQETLLRAWRHLQQNDGDLPLRSWLFTVARNIVIDGSRSARFRYEVCSPDTSEVPDRMGPDEVNSALDRMLIADAMAQLPEAHRAVLSRSFYLGWSTGQIAEDLDIAEGTVKSRLHYALKRLRLILSEMGCRSRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTP0</accession>
    <name>A0A132PTP0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844789.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25634">
        <property type="protein sequence ID" value="KWX25634"/>
        <property type="gene ID" value="AFM11_05255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2936"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="98" mass="10844" checksum="8D1F87149C4D6525" modified="2016-06-08" version="1">MSTATLAAHLTTADLAERLRRSEQTIRYWVAHEGLPAHRMTRRLYFDPAEVDAWLLARRDGAAPDDHRAAIRALVDAAPELTDDQAAKIRAVLTGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTX9</accession>
    <name>A0A132PTX9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ORF">AFM11_00440</name>
        <name evidence="10" type="ORF">AWC31_33555</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842243.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33555"/>
    <dbReference type="EnsemblBacteria" id="KWX25799">
        <property type="protein sequence ID" value="KWX25799"/>
        <property type="gene ID" value="AFM11_00440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11613">
        <property type="protein sequence ID" value="ORX11613"/>
        <property type="gene ID" value="AWC31_33555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.89"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="91"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX11613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="187" mass="21158" checksum="18ABF63A2F57AB12" modified="2016-06-08" version="1">MTTVEKTQPRLKARYREEIREELQKQFEYANVMQIPGVVKVVVNMGVGDAARDAKLINGAVNDLALITGQKPEIRRARKSIAQFKLREGMPIGARVTLRGDRMWEFLDRLISIALPRIRDFRGLSAKQFDGTGNYTFGLNEQSMFHEIDVDSIDRARGMDITVVTSATNDDEGRALLRALGFPFKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU26</accession>
    <name>A0A132PU26_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04755</name>
        <name evidence="3" type="ORF">AWC31_20390</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844616.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20390"/>
    <dbReference type="EnsemblBacteria" id="KWX25552">
        <property type="protein sequence ID" value="KWX25552"/>
        <property type="gene ID" value="AFM11_04755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16415">
        <property type="protein sequence ID" value="ORX16415"/>
        <property type="gene ID" value="AWC31_20390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2832"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="280" mass="29460" checksum="AF00FE0A8A97006A" modified="2016-06-08" version="1">MRETSNPVFRSLPKTQGGYAQFGTGAAGFGAQQVHAQQYAPEYLDQQQTGVSRPLTIDDVVTKTGVTLGVLSIVAVVSYFLVSGNMALAAPFTLIGGIGGLVLVLIATFGRKQDNPAIVLTYAALEGLFLGAVSFLLTFNIQGASAGGLISQAVLGTFGVFFGMLVVYKTGAIRVTPKFTRMLIAAMIGVVVLALGNFVYALFTDGAGPLRDGGPIAIIFSLVCIGLAAFSFLLDFDAADQMIRAGAPEKAAWGIALGLTVTLVWLYIEILRLLSYFNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU63</accession>
    <name>A0A132PU63_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842370.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25845">
        <property type="protein sequence ID" value="KWX25845"/>
        <property type="gene ID" value="AFM11_00690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.141"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023921">
        <property type="entry name" value="ADH_Zn_actinomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03989">
        <property type="entry name" value="Rxyl_3153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="12"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="368" mass="38659" checksum="5D8145D76FC0FA36" modified="2016-06-08" version="1">MKTTAAVLFEAGKPFEIVELELDGPREGEVLINYTAAGLCHSDLHLTDGDLPPRFPIVGGHEGAGIIEDVGPGVTKVKPGDHVVCSFIPSCGTCRYCSTGRQNLCDMGATILDGCMPDGSFRFHSGGEEFGAMCMLGTFSEKATVSANSVVKIDDWIPLETAVLTGCGVPTGWGSATYAGNVRPGDITVVYGIGGIGVNAVQGAAHAGAKYVVVVDPIAFKRETALKFGATHAFADATAAAEKVNELSWGQGADQAIVTVGTVDEEVISAAFGILGKGGTLVVTGMAAPDKLTIHISGLDLTLSEKTIRGTLFGSANPQYDIVRLLRLYDVGQLKLDELVTTKYRLEDVNQGYQDLRDGKNIRGVIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUE7</accession>
    <name>A0A132PUE7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histidinol dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFM11_01375</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 15">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842738.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25956">
        <property type="protein sequence ID" value="KWX25956"/>
        <property type="gene ID" value="AFM11_01375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.282"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KWX25956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="432" mass="45839" checksum="A4859302AB9CE0E2" modified="2016-06-08" version="1">MVEYLKAAPASTVDAEHSRSVQRTVVDIIADIRERGDVAVREYSEKFDNWSPASFKLGPEQVDEIIAGVPSQVLADIRTVQDRVRAFAQHQRDSIRDFEVEPEPGVFLGQKNIPVGSAGAYIPGGRYPLVASAHMTVVTAKVAGVERVTACTPPIRGDIPAATVAALHLAGADEIFLLGGTQAVAALAIGTETIAKVDMLAGPGNAYVAEAKRQLFGEVGIDLFAGPTEVLIIADEHADPFVVAVDLLSQAEHGPDSPAVLITTSTSLGQQVIDQVDKLLVDMPTADFAGPAWRDHGEVAVVEDLGAAYRLADQYASEHVQILTENPREALERMSNYGALFLGEGTCVSYGDKVIGTNHTLPTRGAANYTGGLWVGKYLKTVTYQEVSNPAASAALGELCGRAARVESFEGHARSGDVRAHKFGGAELAWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUI7</accession>
    <name>A0A132PUI7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842806.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25975">
        <property type="protein sequence ID" value="KWX25975"/>
        <property type="gene ID" value="AFM11_01500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.307"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="377" mass="40741" checksum="859FF7B795C04CC2" modified="2016-06-08" version="1">MSNATVIGGGIGGLTAATVLARRGWTVRLHERQPEIRAVGAGIYVWDNGLLALESIGAFDEATHGAHIGPAAEARSHRGKTLYRIDINGDGQARCYTLLREVLIRALVNAARDAGVELVTDSVATAVHANGTVDFDDGHTEVADLVVVADGVHSRLRDSLDLAYRRIRMTQGAARLMIPASPDYLSDEDRVKHLEFFQGRRRLLYTPCTPEWVYLALVCDAGDPAIDGSRVNVAQWQQSFPMLSALLDATADVPIRWDTFEFVQLSTWSRGAVAFLGDAAHAQPPYLGQGGGTAMTNAIALATAVSRPGNGVPGALKAWERHTRPEIERTQRTSYGMRLLNHIPDAVRVPLLSTVGRVPGFSDLHLSTARRQSAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUL5</accession>
    <name>A0A132PUL5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842766.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34395"/>
    <dbReference type="EnsemblBacteria" id="KWX25964">
        <property type="protein sequence ID" value="KWX25964"/>
        <property type="gene ID" value="AFM11_01425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.292"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="129" mass="13929" checksum="1EAFDD808739B375" modified="2016-06-08" version="1">MTGRVVHFEVPFSDGKRAKDFYQQVFGWQVNEYPEMNYTGVATGPVAESGMPAEPGYIGGGMFEREPAYPQGPVITIDVPSIDAALEKIRSLGGEQVGEKTAVGEMGFAAYFKDTEGNVLGLWETAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV27</accession>
    <name>A0A132PV27_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843488.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35640"/>
    <dbReference type="EnsemblBacteria" id="KWX26186">
        <property type="protein sequence ID" value="KWX26186"/>
        <property type="gene ID" value="AFM11_02860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.589"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="52"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="239" mass="25383" checksum="514085CEEB4369FE" modified="2016-06-08" version="1">MAGQTKRINWQVVSGLGLAVLALLCGLWWLSGRDQIKPPPAAAISLDRTFAVLGDSYTEGAGAGSWDNGWVTRVSDDMCWTLVKVSAQGGTGYVSASRQSPGSADFPRRVQNVTAGRPEIVLVQGGLNDLAASSERITSAAVATFNDIKAGIGGGQIIAVGPVVTPRTDPNEVARVSAALEEAARATGVRYIDAAKAQWVHDPKFFVDDGYHLNPSGYEEYARRLIEELKLAGLQPSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVB7</accession>
    <name>A0A132PVB7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843234.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35155"/>
    <dbReference type="EnsemblBacteria" id="KWX26107">
        <property type="protein sequence ID" value="KWX26107"/>
        <property type="gene ID" value="AFM11_02375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.487"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="27604" checksum="EE4092623E0ECB2F" modified="2016-06-08" version="1">MDIEQRVVVVTGAGSGIGRALAEAFAAGGARVVIGDVDQAGANETASRISAAGGSAVALRADAADPADIEALADNAFGPADIYVANAGIIGASGLGTDTDWERILGVNLRAHIRAAEVLVPQWRSRGRGYFVSIASAAGLLSQIGAAGYAVTKHAAVGFAEWLAITYGDDGIGVSCVCPLGVDTPLLHAVRNADEPDALVGAESIVQSGLVISPQDVATATVEAVRSERFLVLPHPQVLDMYRHKGSDYDRWIAGMRRYQRSLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVD2</accession>
    <name>A0A132PVD2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842862.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25992">
        <property type="protein sequence ID" value="KWX25992"/>
        <property type="gene ID" value="AFM11_01645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.339"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="253" mass="27986" checksum="E589E9E6FED9D187" modified="2016-06-08" version="1">MATLAIDGVDIYYEDHGHGEPLLLVHGAAASGRWFGDLIPQLAANHRVILPDLRGLGRSSRVAPLERPQVWVSDLWRLLDSLSVERVHLAGVSLGSRIAGRMVLDNRERVMTLTVDAPIVGLSKSGNASLNTVFTVVDPDSDQAREWQHLHGDDWREAVLFYAATRNTEEFQQYFTLRPHLSDIDVPTLVCRGDLDDAIHPVDDAFIWHKQAPDTQLFIAPGLTQSSIMLERAANFVAEFEAFQARCALGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAV9</accession>
    <name>A0A132PAV9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_35755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000048">
        <property type="protein sequence ID" value="KWX19459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19459">
        <property type="protein sequence ID" value="KWX19459"/>
        <property type="gene ID" value="AFM11_35755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5887"/>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="527"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="9">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX19459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="821" mass="86867" checksum="B380C683ABEE28E4" modified="2016-06-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBE0</accession>
    <name>A0A132PBE0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859648.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19567">
        <property type="protein sequence ID" value="KWX19567"/>
        <property type="gene ID" value="AFM11_35090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5746"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="29352" checksum="F517641B6E99CDF6" modified="2016-06-08" version="1">MSSAIYTFAEERRAWIAAHAGILLFQKRRAELLGKAIRARDRARVGARPDPHDDEVTPPLVFRQTSTATGGFETAIVVACAVAAPIGWPVGRLLYGWITTLIPDRLLGYPIPALLGTAALCGLPLPLFYDPLPTLWAVVVTPWLLGQLPAIFLAAGIYGVLEGWLAVDGSSHWWPLTPVAAEVDDDVFLGGRDVAMPTILDPPPEAAPPARRKPLSMPRIGVPTIHWIPLLCSGIPVGLGITWYLWLILSALLSLPSELLQTNYPPATPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC25</accession>
    <name>A0A132PC25_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ORF">AFM11_33425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858692.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02290"/>
    <dbReference type="EnsemblBacteria" id="KWX19883">
        <property type="protein sequence ID" value="KWX19883"/>
        <property type="gene ID" value="AFM11_33425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5017"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="429"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX19883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="550" mass="59111" checksum="F808D2F7602CE2A0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCB2</accession>
    <name>A0A132PCB2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_33275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858594.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16950"/>
    <dbReference type="EnsemblBacteria" id="KWX19963">
        <property type="protein sequence ID" value="KWX19963"/>
        <property type="gene ID" value="AFM11_33275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4987"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="181"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="311" mass="33082" checksum="A678FD40B19EC213" modified="2016-06-08" version="1">MSEERELLRDTVAALVDKHASPEAVRAAMESERGYDEKLWQLLCEQVGAAALVVPEELGGAGGELADAAVVLEELGKALVPTPLLGTTLAELALLATDQAEPLESLVEGTSIGAVVFDPEYVINGDIADVVIAADGENLTRWTTFTALPKTTMDLTRRLSAVTPGETTPLGSDPGLADTAALLMAAEQIGAASRCLDLTVAYTKDRVQFGRPIGSFQALKHRMADLYVKVASARAVVHDSIADPSPTSASLARYFASEALSAVTAEAVQMHGGIAITWEHDIQLYFKRAHGSAQLLGPPREHLRRLEAEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCS0</accession>
    <name>A0A132PCS0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_32495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858118.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19630"/>
    <dbReference type="EnsemblBacteria" id="KWX20119">
        <property type="protein sequence ID" value="KWX20119"/>
        <property type="gene ID" value="AFM11_32495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4827"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="21652" checksum="798F1A7C6F00D0FB" modified="2016-06-08" version="1">MAILSIGAQFPEYDLTAVIGGDLSEVDAKQPDDYFTRVTDKDHDGKWRIIFFWPKDFTFVCPTEIAAFGKLNDDFEDRDAKVIGVSVDNEFVHFQWRAQHEDLKKLPFPMASDLKRELALATGVLNADGVADRATFIVDPNNEVQFVSVTAGSVGRNVDEVLRVLDALQSDELCACNWKKGDPTIKAGELLAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD43</accession>
    <name>A0A132PD43_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysA</name>
        <name evidence="8" type="ORF">AFM11_33420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858689.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02295"/>
    <dbReference type="EnsemblBacteria" id="KWX19882">
        <property type="protein sequence ID" value="KWX19882"/>
        <property type="gene ID" value="AFM11_33420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5016"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="7">
        <location>
            <begin position="73"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="6">
        <location>
            <begin position="342"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX19882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="474" mass="50161" checksum="4642650FAB83F70C" modified="2016-06-08" version="1">MNAHPAGPRHAEEIHHTATPAKPQTPDEILLLAPNVWPRNLVRGADGVVSIAGVSVTDLAAEFGTPLFVIDEADFRSRCRDIAAAFGGGEYVHYAAKAFLCSEIARWVNEEGLALDVATGGELAVALHAGFPADRITVHGNNKSVEELTMAVKAGVGHVVLDSEIEIERLDAIAGQAGVVQDVLVRVTVGVEAHTHEFISTAHEDQKFGLSLATGAAMDAVRRVFATDNLRLVGLHSHIGSQIFDVAGFELAAHRVIGLLRDVVAEFGVEKTAQISIVDLGGGLGISYLPHDDPPPMQELADKLLAIVRNESAAVGLPAPKLVVEPGRAIAGPGTITLYEVGTVKDVAVSPTAHRRYVSVDGGMSDNIRTSLYAAEYDARLVSRVSDAPAALARIVGKHCESGDIVVRDTWVSDDIAPGDLLGVAATGAYCYSMSSRYNLLCRPAVVAVKDGKARLVLRRETVDDLLSLEVSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDC1</accession>
    <name>A0A132PDC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857131.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26510"/>
    <dbReference type="EnsemblBacteria" id="KWX20341">
        <property type="protein sequence ID" value="KWX20341"/>
        <property type="gene ID" value="AFM11_30790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4059"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="186"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="348" mass="38660" checksum="2E166E3AC69D7400" modified="2016-06-08" version="1">MTTSLTHSIHAASLLDGELVEETDHGSIRRLTADNFPILQGLSIKRLVLNPGAMRTPHWHANANELTYCVSGAALVSVLDSGSQFASFTIKAGEMFHIDSGSLHHIENIGPDPAEFIITFRHERPEDFGLAGAFGAMTDAVLGNTYDLDAADFTAIRRNLVDRSIVARTGDAAVPSTAHFNDPHKFGVEDMTPPVQAAVGSARTARVQFWPALKDLSMYSLRIREDGMREPHWHPATAEMGYVQSGSARMTVMDPDGTLDTWYLNQGDVYFIPRAYPHHIEVFDAPEWHFLIFFDQPFPADIGYRTSISAYSREVLAATFNTHIDDLPNFPFTKSDPLIVNRHNPLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDE5</accession>
    <name>A0A132PDE5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein CstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_30830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857150.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26550"/>
    <dbReference type="EnsemblBacteria" id="KWX20349">
        <property type="protein sequence ID" value="KWX20349"/>
        <property type="gene ID" value="AFM11_30830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4068"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="684"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="69"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="10">
        <location>
            <begin position="505"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX20349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="768" mass="81835" checksum="42D5CDCD425A02D0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDJ1</accession>
    <name>A0A132PDJ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858397.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32430"/>
    <dbReference type="EnsemblBacteria" id="KWX20022">
        <property type="protein sequence ID" value="KWX20022"/>
        <property type="gene ID" value="AFM11_32985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4927"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="158"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="270" mass="29898" checksum="1F22E8D51F00DB7C" modified="2016-06-08" version="1">MTGPALHRPCRALAPYIDFFGYWQRDDDGETHRSRALPRGAATVIIDVSPRQRVDFYAADGATRLDVGTAFVAGAGSISYVTQIDSAQTVLTVHFRPGGAVPFLDGPLGDLENACVGLTEIWGRDGVALHARLIEATSIRHRITLLEEFLLARMRLRHPALTTVLQAIERNPSMRVADAGAQIGLSPKRLIALFRSEVGVTPKTYLRVRRFQAAMRRLDAGAEGGAEIAADLGYFDQAHFVREFRSFTAMTPTEYVRRRMWLPSHVGINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDM3</accession>
    <name>A0A132PDM3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856749.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20436">
        <property type="protein sequence ID" value="KWX20436"/>
        <property type="gene ID" value="AFM11_30075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3909"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019710">
        <property type="entry name" value="DUF4226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10774">
        <property type="entry name" value="DUF4226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="244" mass="24757" checksum="40ABC83CBD495CC5" modified="2016-06-08" version="1">MSILDRLAQDLTATLGALTGEQSGPPKSGPLLPDGPDHDGGGLMPPAEPYSPPPPGSVAPPSGGGPMPRSTLDNLHGTDDAPYPMPVVQDPEALGPGLHWTEIAPGIWMPPGSASEPESPPWQTHTMGWSGEAADEARSADARLAQASRTRGEADQELARGIIDAGAAARSAHERLRTIQADVEAGVAALRPSLDTPAGRQQLATLLDSKASEAREVIGQVQAAAAQAAAAMGAATAGYGSIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDP3</accession>
    <name>A0A132PDP3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856801.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20456">
        <property type="protein sequence ID" value="KWX20456"/>
        <property type="gene ID" value="AFM11_30220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3940"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038611">
        <property type="entry name" value="Arr_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="319" mass="35773" checksum="8B343A618689EF53" modified="2016-06-08" version="1">MRRRQRRGLAVATTYYHGGVPGKRPGELLYPAAHMGLDYTSAYMCQPGLRALAKPKYRPDLVYFTTHLGSARGYAARYGEWGRVMPGDVYVVEPQGPLEPDPDFDHPKVGGVYAASTQPLRITAVVERGVELDRRQQNKECWPYRYNGLWEETHAADGTVLASTEMRSFGVTDEYLALLPKWMDLSEFANDGGLYKRGQPEVRAMPDEILEILAHLGIDTGPHIITNKNIRIAPFVEASAPKNPILLGQFECQECGAQFGGSKQRVEKQTVLDAAVHQAGQELRVVAQFSWGLDGYLHAMLRRSPDRWKWAAVPHRDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEW9</accession>
    <name>A0A132PEW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855683.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10270"/>
    <dbReference type="EnsemblBacteria" id="KWX20888">
        <property type="protein sequence ID" value="KWX20888"/>
        <property type="gene ID" value="AFM11_27735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3421"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="404" mass="42554" checksum="B3AB170BC918E24D" modified="2016-06-08" version="1">MPRVLVVGSGFAGLWAAIGAARRIDQLGRRADDIEITVLTNRPFHDIRVRNYEADLSECRIPLSAVLDPVGVGHVVADVTDIDVHGRTVTAHNTGGTTTFGYHRLVLAAGSQVVRPDVPGLRDLAFDVDTFDGATRLDAHLTRLATGPTRPGIATAVVIGAGLTGIETACELPRRLSDVFAGAVHPRVVLVDHNPLVGSDMGASARPIIETALSDNGIETRTGVAVTGVDKDTVTLSSGEVVVAATVVWCAGMRANLLTAQLPVTLDRLGRVPVDDYLRVEGVAGVFAAGDVAAAKMDDEHMSVMSCQHSRPMGRYAGYNVIGDLVGEPMLALRIPWYVTILDLGPAGAVYTEGWDRQVVATGAEAKATKTTINTARIYPPLTGSRQALFAAAGPELQSRPAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF11</accession>
    <name>A0A132PF11_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp/Glu racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856193.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20797">
        <property type="protein sequence ID" value="KWX20797"/>
        <property type="gene ID" value="AFM11_28615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3603"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="242"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="381" mass="40698" checksum="E015751074180F74" modified="2016-06-08" version="1">MTRIGMIVPSSNTALEPATTRLVAGRPDVTVHFARIPVRAITLGDGGAAFDVETMLAAARLLADAKVDCIVWNGTAGSWLGVEHDRQICAAITDATGVPATTSTLAILQSCHDFGVTALACATPYTGDVVDAIVQEYARHGVSIVSRAEWELTDNFSFADKTAEAVAGLLLEASSPEAQAIALICTNVDGTTVAAKAEKQIGIPVIDSIAATLWWALEVAGADARIPGAGMLLEQGSFRHRAKKIVTELRQQTGCDRTTVRIDDASLGLHVDLCAAESCSPGVRSIQHDPSLDQRKLETVMWLEERREVLVQPAFVEPPYPPQALREVYGVSAQTLGPVERDGELAAWLSAHSINERPWTRSDLAAMDDARQAMAALLNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF80</accession>
    <name>A0A132PF80_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043416428.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20652">
        <property type="protein sequence ID" value="KWX20652"/>
        <property type="gene ID" value="AFM11_28895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3659"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="408" mass="44260" checksum="EBF61BF0A2C54B02" modified="2016-06-08" version="1">MTIFVGDDWAEDHHDIHLMSADGTTLASRRLPEGLAGVGGFHELVATHAEEPTQVVIGIETDRGLWVQALAAAGYQVFSVNPLAVARYRDRHQVSGAKSDAADAKLLADLVRTDRHNHRPIAGDSPDVEAVKVLARAHQNLIWARNRNTNTLRSALREYYPGALEAFDSLSDRDALAILGRAPTPAEAARLSISKIRSALKAAGRQRNLDARALEIQTALRVEQLAAAPAVTAAFGASTRAAVAIIAELNHQIADLEAQLATHFEAHPDADIYLSLPGLGVTLGARVLGEFGDDPNRYTTAKSRKNYAGTSPLTVASGKKRAVLARHVRNRRLYDVIDQWAFCALTNSPGARAFYDQHRAAGDTHHQALRALGNRLVGILHGCLRHHTAYDEHKAWAHRQTTPDAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFQ0</accession>
    <name>A0A132PFQ0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_27050</name>
        <name evidence="7" type="ORF">AWC31_06895</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855277.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06895"/>
    <dbReference type="EnsemblBacteria" id="KWX21133">
        <property type="protein sequence ID" value="KWX21133"/>
        <property type="gene ID" value="AFM11_27050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10321">
        <property type="protein sequence ID" value="ORX10321"/>
        <property type="gene ID" value="AWC31_06895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3284"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX10321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="272" mass="29630" checksum="2693EDABCC4E0968" modified="2016-06-08" version="1">MQRLSFLFRPQWLALFVVVVAFAYLCFTVLAPWQLGKNTKTSRENNQIANSLQADPVPVTTLLPQQDSAAPDDQWRRVTATGHYLPEAEVVARLRVIDGDPAYEVLTPFAVDGGPVVLVDRGYVKPEEGSGVPPIAAPPTGTVTITARLRDSEAIATGKEPFRTDGVQQVYSISTTQIASVTGVPLAGSYLQLVGGQPGGLGEIPLPHLDAGPFLSYGIQWIAFGIVAPIGLGYFVYAEIKQRRRERAAKPAEPDRQLTPEEKLADRYGRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFR4</accession>
    <name>A0A132PFR4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854896.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22930"/>
    <dbReference type="EnsemblBacteria" id="KWX21186">
        <property type="protein sequence ID" value="KWX21186"/>
        <property type="gene ID" value="AFM11_26385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3145"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="167" mass="18884" checksum="78E209E4AE8697E0" modified="2016-06-08" version="1">MSKFTRDELAAAFETFEQTVDRAAQTKDWDVWVEHYTPDVDYIEHAAGTMKGREQVRAWIWKTMTAFPGSYMTAFPSLWSVIDEPTGRIICELDNPMVDPGDGTIISATNISIITYAGDGLWSRQEDIYNPMRFVSAGMKWCRKAAELGNLPDEAAAWMRQFGGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFT9</accession>
    <name>A0A132PFT9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YiaA/B two helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854959.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22830"/>
    <dbReference type="EnsemblBacteria" id="KWX21208">
        <property type="protein sequence ID" value="KWX21208"/>
        <property type="gene ID" value="AFM11_26505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3171"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008024">
        <property type="entry name" value="YiaAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05360">
        <property type="entry name" value="YiaAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="YiaAB" evidence="2">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="94" mass="10330" checksum="7645495ABEEF717B" modified="2016-06-08" version="1">MNTLTDTAKVTAAFFLQAAIAFGVSFLGVLGGIFFLPIDTWQRMFLGMSVLFLVTSAFTLAKVIRDQQEAATVRVRLDEAGMEKLIAEHNPFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG76</accession>
    <name>A0A132PG76_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_25775</name>
        <name evidence="9" type="ORF">AWC31_36120</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854725.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36120"/>
    <dbReference type="EnsemblBacteria" id="KWX21335">
        <property type="protein sequence ID" value="KWX21335"/>
        <property type="gene ID" value="AFM11_25775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12167">
        <property type="protein sequence ID" value="ORX12167"/>
        <property type="gene ID" value="AWC31_36120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3019"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014293">
        <property type="entry name" value="RNA_pol_sigma70_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02947">
        <property type="entry name" value="SigH_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="137"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX12167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="215" mass="24445" checksum="797E3CEA9D58B654" modified="2016-06-08" version="1">MTDVDRVEPETPEATHETDAELTARFERDAIPLLDQLYGGALRMTRNPADAEDLLQETMVKAYAGFRSFREGTNLKAWLYRILTNTYINSYRKKQRQPSEYPTDEITDWQLASNAEHSSTGLRSAEVEALEALPDTEIKAALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRKQLRDLLSDVARDRGFIRGPQLGEPEEVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG80</accession>
    <name>A0A132PG80_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear export factor GLE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854986.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22780"/>
    <dbReference type="EnsemblBacteria" id="KWX21217">
        <property type="protein sequence ID" value="KWX21217"/>
        <property type="gene ID" value="AFM11_26555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3181"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453019" evidence="3">
        <location>
            <begin position="33"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="4">
        <location>
            <begin position="33"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="23423" checksum="6EEB090DF864CD61" modified="2016-06-08" version="1">MKPLTGAPWRALLGTAATVTAVGLLTAAPASAHVHVDADNPAPGSTSILTFRVPGESESGAVTTQLTVALPDVASARTEVMPGWTAKLDRDAAAGTVKSVTWTAAPGVGISSDQFALFKISVRLPESDTVSFPATQTYSDGSVVRWDQAPLPDGSEPEHPAPQLTLSDSTDPAGQDDHGGPAIASPAPAPSTASAVDTAVSTTDNSARWLAGGALTVAAVAVVVALLARRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGC9</accession>
    <name>A0A132PGC9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panB</name>
        <name evidence="10" type="ORF">AFM11_27125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855303.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06975"/>
    <dbReference type="EnsemblBacteria" id="KWX21052">
        <property type="protein sequence ID" value="KWX21052"/>
        <property type="gene ID" value="AFM11_27125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3300"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="29774" checksum="15679103ED5339CA" modified="2016-06-08" version="1">MSEQSVYGAAGVSSDGAQDTKPRTKVRTVTLQKWKAEGHKWAMLTCYDYSSAQVFDDAGIPVLLVGDSAANVVYGYDTTVPITIDELIPLARAVVKGAPHALVVADLPFGSYESSPQQALATATRFMKETGAQAVKLEGGERVAEQIATLTAAGIPVVAHIGFTPQSVNGLGGFRVQGRGDAADQTIADAIAVQEAGAVAVVLEMVPAELATQITGKLTIPTVGIGAGPNCDAQVLVWQDMAGLTSGKTAKFVRRFGDVGGELHRAATQYAQDVAAGVFPAEEHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGG0</accession>
    <name>A0A132PGG0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_25900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854572.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35995"/>
    <dbReference type="EnsemblBacteria" id="KWX21354">
        <property type="protein sequence ID" value="KWX21354"/>
        <property type="gene ID" value="AFM11_25900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3044"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="308" mass="33046" checksum="33D376F19ED49539" modified="2016-06-08" version="1">MERTDNDTWDLATSVGATATMVAAGRARATRAEPALIDDPFAEPLVRAVGIDFFTRWASGDLDAATVDIPGAPWGMQQMTDLLAARTRYFDAFFTDAAHAGIRQAVILASGLDARGYRLAWPAGTVVFEIDVPDVLTFKARTLAQLGAAPTADIREVPIDLRDDWPTSLRASGFDPTAPSAWSAEGLLPFLPADAQDRLLDNITALSASGSRLSCEVSLIGSDPDGASTQELDPITARWQEHGFDVELGELGYPGPRNDVDDYLGARGWTTVRTQLTALLADTGLALPPPIDGRHSLSDNYYSTAVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGK7</accession>
    <name>A0A132PGK7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_24915</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854072.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27170"/>
    <dbReference type="EnsemblBacteria" id="KWX21461">
        <property type="protein sequence ID" value="KWX21461"/>
        <property type="gene ID" value="AFM11_24915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2344"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="455"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX21461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="528" mass="54363" checksum="8170450C6F36C077" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGV7</accession>
    <name>A0A132PGV7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853452.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24295"/>
    <dbReference type="EnsemblBacteria" id="KWX21575">
        <property type="protein sequence ID" value="KWX21575"/>
        <property type="gene ID" value="AFM11_23850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2128"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRK" evidence="2">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="216" mass="23760" checksum="1EFE0C6D30914C88" modified="2016-06-08" version="1">MTLEQDALDATLDQLVEWAKALVIPGERRILGLTGAPGAGKSTVAELLVTALGPDTAVLVPMDGFHLANEVLTDLGILDRKGAHDTFDDGGYARLIATLRAQRIDDPVVYAPRFRREIEEPIGSSIPVRPDVPLVVTEGNYLLLESDAWSEARSCIDEVWFLAPHTEIRHVRLLSRHEAYGKSPEEAAFWAFGSDERNARLIESTAGRADRIVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH35</accession>
    <name>A0A132PH35_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853607.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23990"/>
    <dbReference type="EnsemblBacteria" id="KWX21623">
        <property type="protein sequence ID" value="KWX21623"/>
        <property type="gene ID" value="AFM11_24140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2187"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025329">
        <property type="entry name" value="DUF4235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14019">
        <property type="entry name" value="DUF4235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="90" mass="9589" checksum="255E038AD995882D" modified="2016-06-08" version="1">MSRSSKLLYRPLSIATSVAGGLLASAVFNQIWKRIDEPNLEPPDPKDLERSGAKALTAAAMQGLIFGLVRAAVDRAGAKGYRALAHESPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH51</accession>
    <name>A0A132PH51_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853808.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23545"/>
    <dbReference type="EnsemblBacteria" id="KWX21688">
        <property type="protein sequence ID" value="KWX21688"/>
        <property type="gene ID" value="AFM11_24575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2276"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="402" mass="42554" checksum="D5D64EB657EA0205" modified="2016-06-08" version="1">MGLKGEAAIVGYVELPPERLSTATPAPFTLEQWALLAAAALDDAGLSAELVDGIVTSHLGESEIFVPSTVAEYLGVRANFAELLDLGGASAAGMVWRAAAAVELGICDVVLCALPARYLTPTSELKPKTLSDAVFFGSSSNQFGSPQAEFEIPYGNLGQNGPYGQVAQRYAYEYGYDERAMAKIVVDQRVNANHTDGAIWKDKPLTIEDVLASPVIADPLHMLEIVMPCVGGAAVVVANADVAAKARHRPVWVKGFGEHVPFKTPTYAENLLDTPIRKAADTAFGMTGLTRDQMDMVSIYDCYTITVLLSLEDAGFCEKGKGMAFVSDHDLTFRGDFPLNTAGGQLGFGQAGLAGGMHHVCDATRQIMGRAGAAQVTECDRAFVSGNGGILSEQTTLILEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH54</accession>
    <name>A0A132PH54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23705"/>
    <dbReference type="EnsemblBacteria" id="KWX21665">
        <property type="protein sequence ID" value="KWX21665"/>
        <property type="gene ID" value="AFM11_24420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2244"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453340" evidence="2">
        <location>
            <begin position="29"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="361" mass="38090" checksum="E73AD34DECF10442" modified="2016-06-08" version="1">MSRRVAAIAAAALMLPALCMAGPLPGAAAYSREGLPVEYLQIPSAAMGRDIKVTFQGGGPHALYLLDGLRAQDDANGWDINTAAFEWYYESGISVVMPVGGQSSFYTDWYRPAAGSAGVTTYKWETFLTQELPAWLAANRGVAPTGNAVVGLSMSGGAALNLAIWHPYQFIFAGALSGFLNPSQGLWPTMIGFAMKDAGGYNATDMWGTSNDPAWRRNDPTVNINRLVANNTAVWVYCGNGTPGDLDVAGDFGQLYSAQFLENITVNSNKEFQQKYVAAGGRNAVFNFPPNGTHNWNYWGAQLQAMKADMLRVLGVGVTPAVPAAPAAPAPAVPAPVAPVPGVSTQPAVLPAQALPAVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHA0</accession>
    <name>A0A132PHA0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF732 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853881.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24050"/>
    <dbReference type="EnsemblBacteria" id="KWX21715">
        <property type="protein sequence ID" value="KWX21715"/>
        <property type="gene ID" value="AFM11_24070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2173"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="2">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="301" mass="31940" checksum="341AB4B5131C7C75" modified="2016-06-08" version="1">MWKFRRRGSTPVPCPYCGSPVDADETCGRCGPSKTSPGLSGWRPDPTARHEGRYYVAGRPTNRVRNGKAESTDPVGGQLLPDYVELPARSGLRYTWLGTGVATAVLVFVAAVVWVLLRADHGSPLPPEARYLSSLKDAGLTDQFNSDANAVAHGRQVCRQLEDGGPQQGLHADKIAVDAFCPDFAHGFHILETASVPGTFVLIDTAGTDAIASDGSSCEGANGYADVGPTTPVIVKSGKGEILTTTSLGEGKGGNANCTFSFTFPITEGQDRYVVCIGRRGEFIYTFEQLRSRGVQVSLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHA5</accession>
    <name>A0A132PHA5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853939.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23610"/>
    <dbReference type="EnsemblBacteria" id="KWX21738">
        <property type="protein sequence ID" value="KWX21738"/>
        <property type="gene ID" value="AFM11_24510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2263"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="409" mass="44552" checksum="5C0D296E109D5B7F" modified="2016-06-08" version="1">MDGKISVPTDLDAVTDIGDEDHSDIDAAAIERIWQSVQHWYRAGMHPAIQVCLRRNGKVVLNRAIGHGWGNGPDDPQDAEKIPVTTETPFCVYSAAKAISSTVVHMLVERGHFSLDDRVCDYLPNYTSHGKDRTTIRHVMTHSAGVPIHTGPRPDVTRVNDSEYTREQLATLKPLYRPGLVHIYHGLTWGPLIREIVSAATGRNIRDILAEEILDPLKFRWTNYGVLPEEVPLVAPSHVTGKPLPAPIAAAFRAAVGGTPDRIIPLSNTPLFLTSIVPSSSTVSTADELSRFAEILRRGGELDGVRIMSPETLRAATAPCRRMRPDVATGLKPMRWSTGYMLGGKRFGPFGRNTPSAFGHTGLVDIAVWADPARKLSAAVVSSGKPGGQRDAKRYPAVLDRIAAEIPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHG8</accession>
    <name>A0A132PHG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_23170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853049.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27935"/>
    <dbReference type="EnsemblBacteria" id="KWX21761">
        <property type="protein sequence ID" value="KWX21761"/>
        <property type="gene ID" value="AFM11_23170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1986"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="338" mass="37261" checksum="D18D485F55A921F2" modified="2016-06-08" version="1">MSEAPERIVERGTLLQVTDLYVRFATDEGVVRAVDGVSFSLKPGEILAVVGESGSGKSVTAQTLIGLTRSSNAAIEGSIDFGGREINGLDDDELRDVRGEHIAMVFQDPMTSLNPVYRVGDQIIEMIRAHRDVSKAQAREQAVELLRAVGIPHPERRVHDYPHEFSGGMRQRVMIAMALALEPEVLIADEPTTALDVTVQAQILRLVDQLNRDRELAVVLITHDLGVVAEVADRVVVMYAGQIVEDGSLEEIFYDPQHPYTWGLLGSLPRVEDSHPDRLPQIPGQPPSLLNPPSGCRFAPRCPHVFDQCSQPPPLESRDGGSHLDRCWLQPAEKRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHI3</accession>
    <name>A0A132PHI3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853746.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23685"/>
    <dbReference type="EnsemblBacteria" id="KWX21667">
        <property type="protein sequence ID" value="KWX21667"/>
        <property type="gene ID" value="AFM11_24440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2248"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="333" mass="38017" checksum="200EF375EE36CF18" modified="2016-06-08" version="1">MRARTYNQSHAPRAHTGGRRISIYWTWSYPWESQRDPAEVYNRFSTMTEVRNVAWPAYETPEYDAANFLQGIAGTLELFHRSTLSFQELAEEATGHPVAVFQRIDQAGYKLPIDDRILADTDTLMVFGLDHLLSQQVAAPDEIAAITEWLKREGTCLLLAPHHDVGFTDDYAQRQVEYKHHGDRLVPRQQRFGQYTRSLMHALDVPVRNTWGLRPAVVNGTKEIAPLTAVRDLDSLRLLDNVVTFNFHPHLPHYALTAPETDQLRVLGRQRIDPNRPHPFTASGNTEFNALIWMPPTGQRSGDILLIDSTHFTTLFGGTDSLRNLWHNLATMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHJ4</accession>
    <name>A0A132PHJ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853201.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28185"/>
    <dbReference type="EnsemblBacteria" id="KWX21810">
        <property type="protein sequence ID" value="KWX21810"/>
        <property type="gene ID" value="AFM11_23460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2047"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453084" evidence="2">
        <location>
            <begin position="25"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="181" mass="18591" checksum="53F61B0ED621FEDB" modified="2016-06-08" version="1">MNGRLLLGCLLAASVVLAGCQSDIDGSPVTSPQSPTEPSFPTARPTRSSPAPPPSSTVAAPPSAKPPAGATPLEPQNGYVFIETKSGKTRCQLSTQDIGCESDFSNAPDIDGLPANGVELSADGNMRWVLGNLGAIPAVTLDYRTYTALGWTIEAGSDGTRFTNDASGHGMVVAVEGVENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHL1</accession>
    <name>A0A132PHL1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 6">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_23365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 6"/>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853149.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28090"/>
    <dbReference type="EnsemblBacteria" id="KWX21793">
        <property type="protein sequence ID" value="KWX21793"/>
        <property type="gene ID" value="AFM11_23365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2028"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="287" mass="31300" checksum="B78378FE275B4023" modified="2016-06-08" version="1">MRGIILAGGSGTRLYPITMGASKQLLPVYDKPMIYYPLSTLMMAGIRDIQVITTAEDAPAFRRLLGDGSGFGIDLSYAVQDRPDGLAQAFVIGADHIGADKVALVLGDNIFYGPGLGTSLRRFQNVSGGAIFAYWVADPTAYGVVEFSADGTALSLEEKPATPKSHYAVPGLYFYDNDVIEIARSLRPSARGEYEITEINQVYLNQGRLAVEVMARGTAWLDTGTFDSLLDASDYVRTIERRQGLKISVPEEVAWRVGFIDDEQLAARAHTLLKSGYGAYLLELLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHM9</accession>
    <name>A0A132PHM9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853322.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28410"/>
    <dbReference type="EnsemblBacteria" id="KWX21850">
        <property type="protein sequence ID" value="KWX21850"/>
        <property type="gene ID" value="AFM11_23690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2094"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="31678" checksum="FF77E2559FD85045" modified="2016-06-08" version="1">MTERARIDFPARIGVWWASDTWSMPEAQQVARDIEALGYGSLFLPEVVGKDALTQSAAFLAATDRLVIGTGIANIHVRVPSAAESGARTLTALYPGRFVLGLGVSHGPLVEHGLGGTYAKPLATMRTYLDRMAAVPEQIEPGVGRPPRLLAALGPKMIELSGSHADGAHPYLVTPAHTATTREILGQDRWVVSEQAVAIGGDEADQLARAHTHLEVYSGLPNYRNSWLRQGFDESDLVRGGSDRLARGLVGMGSPEQAAAAITAHLDAGADHVVVQALGENPTADPRPALRELAGALGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI24</accession>
    <name>A0A132PI24_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_22280</name>
        <name evidence="7" type="ORF">AWC31_08930</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852673.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08930"/>
    <dbReference type="EnsemblBacteria" id="KWX21904">
        <property type="protein sequence ID" value="KWX21904"/>
        <property type="gene ID" value="AFM11_22280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10267">
        <property type="protein sequence ID" value="ORX10267"/>
        <property type="gene ID" value="AWC31_08930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1806"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005769">
        <property type="entry name" value="PhnE/PtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01097">
        <property type="entry name" value="PhnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="80"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX10267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="281" mass="29420" checksum="3E2BCDE964B241A9" modified="2016-06-08" version="1">MTSTATRTPHPPTQPPRVRRPSLLTLVIVLVVGGLLVHGWTQGAAVRPDSLLTGMFRLGEFAQDAVPPDVQRIGPILKALLVTVEMALLGTIIGVALSLPLAVLAARNTTPHWSLYAASRGVITVSRTIPDLVWGLVFVIAVGLGPEAGVLAIAVDVMGFCGRFFAESIEDIDPGRIEGLRALGASHAGVLLGGVIPACLPSFVTTSMFALESSARSSVVLGLVGAGGIGIELATSMTLLRYDEALTIILAILGVVVVFERVSAAIRRRVLGKVSGERWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI73</accession>
    <name>A0A132PI73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852965.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08535"/>
    <dbReference type="EnsemblBacteria" id="KWX22049">
        <property type="protein sequence ID" value="KWX22049"/>
        <property type="gene ID" value="AFM11_22670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1884"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="332" mass="35090" checksum="9B0D9F35618C547C" modified="2016-06-08" version="1">MDSIGRDQLALREVAPPEPGPGQVLVDVAAVSLNYRDKMVIETGRGLPLRFPFTPGSDLAGTVVGIGAGVTRLQVGDRVISTFTPDWRDGARGGDARTPSYRTLGGYYPGVLADQVCFSEEWFVRAPATLSSAEASTLPCAALTAWFALVERGRVHAGDTVLVEGTGGVSLFGIQIAKAHGARVIVSGSTGKLDRALALGADDGVDRRREDWVEAIYELTDDHGADHVLEIVGGAHLGQAVQVTAVGGTIHQIGALEGFEISAPVAPLLFKDIVIQGIGTGHRRALEDLVAAVDRIALKPVIDSRYALADLPSALDRLDRGPFGKIVIEFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI91</accession>
    <name>A0A132PI91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852911.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08220"/>
    <dbReference type="EnsemblBacteria" id="KWX22023">
        <property type="protein sequence ID" value="KWX22023"/>
        <property type="gene ID" value="AFM11_22985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1951"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="385" mass="41950" checksum="8ADC01B42EC13DA7" modified="2016-06-08" version="1">MPVADMRGVHDWFLHRGLPLVLTRRVRSHRLIERSAPMVGALGGVIALMLTLAELTEPDVDVGAVVKLGVLTAVLFAAPFALELLHRARTTRGDAGRRSAALLVMALFVFGLPFADGGFSGFAAAEAFGFAVVAALAVWLTYLGFGSIALWAFRFAWVQLGALGTLMSRALPLMMLTVVVYFTGELWQLSARMTRQRLWETIAFLSAIAILFMVATIRDEVRALREDRAALDDPATLLAGTPLALETGREAPQRTPLSLAEQFNVVAVMVVSQAIQVVFFTIGLFVFFLGLGMIAIPDDVLVLWSAEEACQVGEPPCAGTWFGIHIPLPQTVVHMSLFVAVLSGLYFTVSTSVDPLYRQRFFDPLIADVAVSLAGRDAYLELERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIB1</accession>
    <name>A0A132PIB1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852722.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08785"/>
    <dbReference type="EnsemblBacteria" id="KWX21927">
        <property type="protein sequence ID" value="KWX21927"/>
        <property type="gene ID" value="AFM11_22425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1835"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="39342" checksum="038A324DAEADB203" modified="2016-06-08" version="1">MTTRATTDDRDEPLGPDSLTWKYFGDLRTGMLGVWIGAIQNMYPELGAGVEDHSILLREPLQRVARSVYPIMGVVYDGDRAAQTGAQIKGFHTTIKGVDAKGRRYHALNPETFYWAHATFFMLIIKTAEYFCGGLTEAEKRQLFDEHVQWYRMYGMSMRPVPATWEEFQEYWDAKCRDELEINRATLDIFSIRIPKPWFVLMPTPVWDQLFKPLVGAQRWIAAGLFDPAVREKAGMRWTPGDEVLLRIFGKMVELAFVAVPDEIRLHPRAISAYRRAAGRLPADAPLVEAPGFMAPPRDRWGLPMHYVPQRKTLLDRAGSLVHTTFSLPALRPARRPAPRRNSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PID2</accession>
    <name>A0A132PID2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852303.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04165"/>
    <dbReference type="EnsemblBacteria" id="KWX22063">
        <property type="protein sequence ID" value="KWX22063"/>
        <property type="gene ID" value="AFM11_21350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1617"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="182" mass="19039" checksum="A3DC3CC664D1FDA4" modified="2016-06-08" version="1">MTSGPDNETGDQRGSIRWQEPGKTRPRQPTVAEARQRDKAQKAREAAARFAELQEQKARERSARNGKILMGSVAVVGVVGAVALGYHLLHKDEVDAACVKDGTNEVVPDEYCSSGYSSSGGTFIYAGSPYRYYYGGTNGGVGTTARGGTLELPKGTTAKTKSGSSISRGGFGSSSSYGSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ86</accession>
    <name>A0A132PJ86_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851834.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11085"/>
    <dbReference type="EnsemblBacteria" id="KWX22391">
        <property type="protein sequence ID" value="KWX22391"/>
        <property type="gene ID" value="AFM11_19745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1283"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="324"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="408" mass="42932" checksum="87EDE95031E240A1" modified="2016-06-08" version="1">MTTSSTFAIIGGGLAGAKAAEALRDKDFDGHVVLFAAEDKLPYERPPLSKEYLAGKKALADFTVDPAAWYRDHNVELRLGTEVTAVNPADHTITLPDDSTVSYDKLLLATGSAPKRPPIPGADAAGVHYLRTIDDAAALNSALTEGSSLAVVGAGWIGMEVAASARQRGVNVTVVETARLPLLGALGAEVGEVFARLHREHGVDLRLNETVQEITTSGGTATGLRLGDGSTVPADAVLVAVGAAPNIGLAERAGLATADGGVLVDAALRTSDADIYAVGDIAAAQHPLFGVRIRTEHWANALKQPAVAAAGMIGRTAEYDDLPYFFTDQYDLGMEYVGHAPSYERVVFRGDVAGREFVAFWLDADNRVLAGMNVNVWDVLDDIKALIRSRVAVDPERLADTGQPLDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJI6</accession>
    <name>A0A132PJI6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_20335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851943.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22500">
        <property type="protein sequence ID" value="KWX22500"/>
        <property type="gene ID" value="AFM11_20335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1400"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="15"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="318" mass="32818" checksum="0B002FDB7DC4E6C3" modified="2016-06-08" version="1">MGNEDGTRAIVTLTMNPALDITCDADVVRPTDKIRCSATRYDPGGGGINVARVARVLGAGARAVFLAGGPTGELVTALVRDAGVPLRRVEIAGSTRESFTVNERSTGEQFRFVLEGPTVTPAEQSRCLQALCAAADAAQFVVASGSLPPGVPPDWYQRVADLCADVGARLILDTSGGGLTHVKSGVFLLKPSLRELRECVGQELKTESSQVEAAQDLILRGVAQSVLVSLGADGALLVTASDSLRFAAIQVTAGSGVGAGDAMVAAITVGLTRGWSMAKSVRYGIAAGAAMVLTPGTATCNRTDVERFFEQTPADLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJN1</accession>
    <name>A0A132PJN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851508.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22340"/>
    <dbReference type="EnsemblBacteria" id="KWX22559">
        <property type="protein sequence ID" value="KWX22559"/>
        <property type="gene ID" value="AFM11_18735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1084"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453129" evidence="2">
        <location>
            <begin position="37"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="237" mass="23995" checksum="E68258000B2488D7" modified="2016-06-08" version="1">MSSSSGLPRLAVAVATGVLTGALAFVSLNAAPLAGAAPPCPDVQVVFARGTFEPPGVGVTGQAFVDALRGKLGDRSMDVYAVNYPASLDFPRAADGVIDASNKVRDVAANCPNTKTVLGGYSQGAAVAAYITADAVPANFVLPPGITGPMPPDVADSVAAVTLFGKPSTGFMNIVQSTAPPINIGHLYTDKTIDLCIDTDPVCSPSGGDAGTHNLYATNGMVDEAATYVAQRVQART</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJP0</accession>
    <name>A0A132PJP0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18705</name>
        <name evidence="3" type="ORF">AWC31_22390</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851500.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22556">
        <property type="protein sequence ID" value="KWX22556"/>
        <property type="gene ID" value="AFM11_18705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15347">
        <property type="protein sequence ID" value="ORX15347"/>
        <property type="gene ID" value="AWC31_22390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1078"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="170" mass="18596" checksum="1586B2F850FCF8DC" modified="2016-06-08" version="1">MEGMIAGRTAGDMPGLDIAEQRSWQNYLDSALRLYATLNRSLVDAHHLTLNDVRLLDILDKSPTGSARMGDLAERLMSLPSRVTRQIRRLEVQNLVTRCASPDDGRGVIATITDDGRTAVREAMVTYGQGVRAHFLGRLSRPQMAAMGENCRRISAALKNGAPPAKIGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJW9</accession>
    <name>A0A132PJW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851671.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22638">
        <property type="protein sequence ID" value="KWX22638"/>
        <property type="gene ID" value="AFM11_19255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1185"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="580" mass="63459" checksum="D79702496A86D6FC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJZ3</accession>
    <name>A0A132PJZ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MgtE integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_20385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22507">
        <property type="protein sequence ID" value="KWX22507"/>
        <property type="gene ID" value="AFM11_20385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1411"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="326" mass="33862" checksum="F04FB2ED93B336E9" modified="2016-06-08" version="1">MVSDAKPDLFSPDTALEHARTRVPMAAATDSVSATLESMRGKPFDSTAAVAVLDDGRLIGIATIERLLAAGEEATIGDIMDASPPIVATDTDQEHAAWQAVQRDEPGLAVVDADGRFRGLIAPQQLLGVLLAEHDEDMARLGGFLHSVESARTASVEGVSQRLWHRLPWLAMGLLGVMVSAGLMSAFEAQLDATLAVAYFVPGIVYLADAVGTQTETLAIRGLSVGIGIRRILAPEAVTGLLVGVLLGLAMLPVVVLMTGDWMLAVAVALAVLAASGIATVVALLLPWVLQAFGKDPAFGSGPLATVVQDLLSIVIYLGAVTAFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK63</accession>
    <name>A0A132PK63_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hercynine oxygenase</fullName>
            <ecNumber evidence="1">1.14.99.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtB</name>
        <name evidence="4" type="ORF">AFM11_19585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O</text>
            <dbReference type="Rhea" id="RHEA:42672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="EC" id="1.14.99.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EgtB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.50" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15655"/>
    <dbReference type="EnsemblBacteria" id="KWX22693">
        <property type="protein sequence ID" value="KWX22693"/>
        <property type="gene ID" value="AFM11_19585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1250"/>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044875">
        <property type="term" value="F:gamma-glutamyl hercynylcysteine sulfoxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02035">
        <property type="entry name" value="EgtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017806">
        <property type="entry name" value="EgtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032890">
        <property type="entry name" value="EgtB_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03440">
        <property type="entry name" value="egtB_TIGR03440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="3">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="166"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Gamma-glutamylcysteine binding" evidence="1">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="425" mass="47621" checksum="4DBB0C46CE89534C" modified="2016-06-08" version="1">MTTREMLARELTRARERTLRLVDFDDAELHRQYNPLMSPLVWDLAHIGQQEELWLLRDGDPNRPGMLTPEVDRLYDAFVHSRASRVDLPLLPPADARAYCATVRSKALDALDALHDEDPGFNFGLVISHENQHDETMLQALSLREGPAILDAGAALPAGRSGLAGTSVLIPGGPFVLGVDELTEPHSLDNERPPHVVDVASFRIGRVPVTNAEWREFIADGGYDQPRWWSERGWSHRQDAGLTAPQFWNADGTRTRFGHTEAIPPDEPVQHVTYFEAEAYAAWAGARLPTEIEWEKACAWDPVAGSRRRFPWGASEPTEMLVNLGGDALRPAPVGAYPNGASAYGVEQMLGDVWEWTSSPLRPWPGFTPMVYDRYTEPFFDGDYKVLRGGSWAVAPSILRPSFRNWDHPIRRQIFSGVRLAWDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK77</accession>
    <name>A0A132PK77_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="3" type="ORF">AFM11_19445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15530"/>
    <dbReference type="EnsemblBacteria" id="KWX22735">
        <property type="protein sequence ID" value="KWX22735"/>
        <property type="gene ID" value="AFM11_19445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1222"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="223" mass="23670" checksum="25D4B2611EFF1B73" modified="2016-06-08" version="1">MGTYGDGGNAVVLRQRLRVRGIDAEIVEITLSEPVPDSLDLYTLGGAEDYAQRLATKHLIRYPGLQRAAERGAPVLAICAAIQVLGHWYETSAGERVDGVGLLDVTTSPQESRTIGEVASKPLLAGLTQPLTGFENHRGGTVLGSDARPLAAVTKGAGNRAGDGYDGAVQGSVIATYLHGPCLARNPELADHLLSRVVGELPPLELPEVDQLRRERLAAPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKP5</accession>
    <name>A0A132PKP5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CIS_tube domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11955"/>
    <dbReference type="EnsemblBacteria" id="KWX22920">
        <property type="protein sequence ID" value="KWX22920"/>
        <property type="gene ID" value="AFM11_17885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.931"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045361">
        <property type="entry name" value="CIS_tube_prot_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19266">
        <property type="entry name" value="CIS_tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIS_tube" evidence="2">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="208" mass="22910" checksum="6F7AB1144FCEA1EA" modified="2016-06-08" version="1">MGSLKDKVTFQFNPKEVSITKSAKWERKPTKEKKAGPPEFSGSEPCKLSLELYFDATAKDGVDVVASVDKLFSCCVPCTEGDKAMPFLVVFNWGQVKSFAAYISQVQAKYTRFAANGVPIRATCSINLEEIDVTPDPKQNPTSGSQWADDVHTMVTGDSLALLAYREYGDPQLWRPLAAYNDIDDPMRVPNGTRLKLPRLEALAARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKQ6</accession>
    <name>A0A132PKQ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_18055</name>
        <name evidence="8" type="ORF">AWC31_12125</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851245.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12125"/>
    <dbReference type="EnsemblBacteria" id="KWX22926">
        <property type="protein sequence ID" value="KWX22926"/>
        <property type="gene ID" value="AFM11_18055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18887">
        <property type="protein sequence ID" value="ORX18887"/>
        <property type="gene ID" value="AWC31_12125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.967"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="137"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX18887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="222" mass="24411" checksum="C3B45C4DCD75E9F1" modified="2016-06-08" version="1">MKVAIAGAGAVGRSIARELLESNHEVTLLERNLDHIDVDAIPAAHWRLGDACELTMLESVRLEEFDVVIAATGDDKVNVVVSLLAKTEFAVPRVVARVNDPRNEWLFDENWGVDVAVSTPRMLASLVEEAVAVGDLVRLMEFRRGQANLVEITLPDDTPWGGKPVKRLELPRDAALVTILRGARVIVPESDEPLEGGDELLFVAVTEVEDQLRELLLRPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKR8</accession>
    <name>A0A132PKR8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850582.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20005"/>
    <dbReference type="EnsemblBacteria" id="KWX22945">
        <property type="protein sequence ID" value="KWX22945"/>
        <property type="gene ID" value="AFM11_16315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.611"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="200" mass="21814" checksum="C22AF96C9B3881CD" modified="2016-06-08" version="1">MDLQVQKFTAKGAATRRRIIEGAAAEIRSRGVAETTLDDIRARTQTSKSQLFHYFPDGKDELLLAVAQHEAKMVLEDQQPYLGELTSWAAWQRWRDAVVDRYRRQGQSCPLSMLMSEIGRTTPGAQAVTKALLRQWHDEITAGIQSMQAQGKVAGGVDADRMGAALLAGIQGGVGIMLATGDLSYLEAALDTGIGNLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLF7</accession>
    <name>A0A132PLF7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_17405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850978.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01990"/>
    <dbReference type="EnsemblBacteria" id="KWX23133">
        <property type="protein sequence ID" value="KWX23133"/>
        <property type="gene ID" value="AFM11_17405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.835"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="41"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="396"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="429"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX23133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="630" mass="68886" checksum="AC05BC1628646B42" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLG8</accession>
    <name>A0A132PLG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16500</name>
        <name evidence="3" type="ORF">AWC31_19820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851001.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19820"/>
    <dbReference type="EnsemblBacteria" id="KWX23143">
        <property type="protein sequence ID" value="KWX23143"/>
        <property type="gene ID" value="AFM11_16500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16721">
        <property type="protein sequence ID" value="ORX16721"/>
        <property type="gene ID" value="AWC31_19820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.648"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="147" mass="16354" checksum="EFB2BD7825862422" modified="2016-06-08" version="1">MGRQVFDDKLLALISGNSMGVLATIKQDGRPQLSNVSYYFDPRAVTIQVSITEPRAKTRNLRRDPRASIHVSSDDGWAYAVAEGDAILTPPAANPHDDTVEGLIALYRNIAGEHPDWDDYRRAMVDDRRVLLTLPISHLYGMPPGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLH2</accession>
    <name>A0A132PLH2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="6 12">1.3.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_18140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:43436"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="1.3.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:43437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.15" evidence="6 12"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851276.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12210"/>
    <dbReference type="EnsemblBacteria" id="KWX22852">
        <property type="protein sequence ID" value="KWX22852"/>
        <property type="gene ID" value="AFM11_18140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.985"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="8 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX22852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="451" mass="47100" checksum="F4AAF13948DE3B7B" modified="2016-06-08" version="1">MSAAYCIVGGGISGLVAAYRLRMAAGPHADITLLDPADRLGGVLRTERVGGQSLDVGAEAFVARRPEMPALLAELGLAGRQIGTTGVRPLIYSGARLHPLPQGTLQGIPAQASSVLGLVDDATVARILDERTRPFSWRPGADPAVAELVGDRFGQQVVQRSVDPLLTGVYAGSAATIGLRSAVPTLAAALDRGARNLTEAVRDALGPPVTGPVFGALDGGYTVLLEELQRRAGVRWAQVAAVRVDRGTRGWEVLDDEGNRWRADGVVLAVPAPGLPRLIEHVAPRTAAAARRIRVASAAVVALALPGGTPLPQQSGVLVASGERLNAKAVTLTSRKWGRRGNVELLRLSFGRYGDDLARSTGDEDLLAWSMRDLQTLFGIAVEPVDCHVHRWIDAMPQYGPGHADLIAELRAGLPPTLVVAGGYLDGIGVPACVGTATRAATALVNSGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLI7</accession>
    <name>A0A132PLI7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_15390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850214.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23208">
        <property type="protein sequence ID" value="KWX23208"/>
        <property type="gene ID" value="AFM11_15390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7193"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="155" mass="16890" checksum="F8E6CE31DC24BC68" modified="2016-06-08" version="1">MTGTDSFLERWFEDYAVGQVERGGSAVITASDIADFARLTHDDHPAHTDAEFAEERFGGLLAHGVLSFAVVVGLTMERNPRLVAYGYDRIRFPAPVLAGDTVAAVSEVVDVSPHARNPKIGLVTKAYTGTNQHGKTVLVCRHIVAVERRNSEEPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLJ2</accession>
    <name>A0A132PLJ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22872">
        <property type="protein sequence ID" value="KWX22872"/>
        <property type="gene ID" value="AFM11_18275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1012"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="454" mass="48163" checksum="EB81D45B74A28632" modified="2016-06-08" version="1">MQDGRRGSLPRRRWRWVVAGVIAVVACVAVVTVVAARDTERVVVDATTAAAVAIPATPPVLGDKRFELKVSDRSLAQPHVVAAGPGFAVAIDNSLTGYGPDGSQRWHYRTSGATFTEANVYDNGAVIIAALADGTVDTDRPNHDDPPFPQRLVAFDANTGQQLWDSRRDDLRGAFAGYRNPEGGTQTPPQTRFLASSKGTRMVGFDARTGEEAWQESIGCSKTAYTPTQLVCLNVGGADFRAVVVDAATGARTGEWPVSVPEADRPETWMFVSDIAVPSGGQGLAITMWFSTRGTVEQLPSQVVYLDTTTGASVRLGQGNTTTVIGADPRGDLLVTTSSEEYALTIPREYRSATVTLHGPDGAQRCTFAADAAPSGGEHNATAWLTDQLINVVDRGTEANPEQSLTVFDRDCRQLSATPLPAATTITGIVPAPGVTVIARSDDTGTYLDGYAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLP2</accession>
    <name>A0A132PLP2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_15420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850224.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16355"/>
    <dbReference type="EnsemblBacteria" id="KWX23213">
        <property type="protein sequence ID" value="KWX23213"/>
        <property type="gene ID" value="AFM11_15420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7199"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="76"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="29486" checksum="2E797D13C60348A3" modified="2016-06-08" version="1">MTDEDSVSVRKVKSAVRTVELLEYLAARPDQPCRIRDICAALEMPRSSAHALLRTLVAQGWVRSDDAGSQYSIGVRALLVGTSYLDADPYLPMITPFLDDLRGDLDETFHLGRLDGHDVVYLATRESRQYIRTTNKVGRRLPAYTTALGKALLAERFGAELDAHIPPTLTPLTPRTVTDRAALEASLDETRVRGYATEDEENTTGIKCFAVSLRYLQPAQDAISASVPLSRLTPAREREIVDALRMVCDKVSRVVRPVANGDKWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLR6</accession>
    <name>A0A132PLR6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_15890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850384.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16465"/>
    <dbReference type="EnsemblBacteria" id="KWX23290">
        <property type="protein sequence ID" value="KWX23290"/>
        <property type="gene ID" value="AFM11_15890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7303"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="178" mass="19300" checksum="6E732DF3DD4FDDE0" modified="2016-06-08" version="1">MSRVVLSIGSNLGDRLARLQSVLDGLGPAVRAVSPVYETAAWGGVEQGPFLNAVLLADDPDLDGHGWLRRGQELEQAAGRVRGQRWGPRTLDVDLVTCHDGDVEIISRDDGLTLPHPLAHLRAFVLIPWLAVDPDATLTVSGEQRPVQRLLSEIDPAERAGVTRTDLVLELRTEPAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLU7</accession>
    <name>A0A132PLU7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850444.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16625"/>
    <dbReference type="EnsemblBacteria" id="KWX23320">
        <property type="protein sequence ID" value="KWX23320"/>
        <property type="gene ID" value="AFM11_16050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7335"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453167" evidence="1">
        <location>
            <begin position="26"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="30"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="326" mass="35474" checksum="75078186D419296A" modified="2016-06-08" version="1">MRRAASLLMLFALAATFQSVPRAVAAPDGFDLQSHRGGRGETTEESLRAFAKSLELGVSTLELDIVLTKDHQPLAWHDPAIDAAKCSDTAPAFPGDPMYPYVGKLVHDLTIEQVRTLDCGKLLSGYPDAEVVRGNKIATLPEVFALTDSYRADVRFNIETKIEADKPETSAGPEEFVDVILAAVRAAGKVDKVDIQSFDWRTLPLVQRAEPSIPRVALWDETTWVPDSPWLAGVNPAVVGDPIAGAMVVGANVLSPNYRLVTDRAFVDRAHGLGLRVIPWTVNDVETMRAQIALGVDGIITDYPTRLRSVMAELGMPLPPAYHRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLV9</accession>
    <name>A0A132PLV9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tellurium resistance protein TerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_15540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850268.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16245"/>
    <dbReference type="EnsemblBacteria" id="KWX23234">
        <property type="protein sequence ID" value="KWX23234"/>
        <property type="gene ID" value="AFM11_15540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7224"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="322" mass="36238" checksum="C1F47EDC3225D509" modified="2016-06-08" version="1">MQVTQLEWIITLTVTIAVLLFDVIVIGRRPHEPSTRETATYLSIYIGMAVLFGVWVWFFHGSQFGLEFFAGWLTEYSLSVDNLFIFLIIMASFKVPRIYQQQALLVGIILALIFRGIFIALGAVAINQFSWVFYIFGAFLVYTAIGLVKDTDHDDDGDNAVVRFARKHLRTTDKWDGLRLWINENGTRLMTPMFLVIVALGTTDLLFALDSIPAIYGLTQEPYLVFTANVFALMGLRQLYFLLGDLLKRLVYLSQGLAFILAFIGVKLILHALHENELPFINGGEPVHVPEIPTLASLGVIIVTLLVTTVASLYKTRVRDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLW7</accession>
    <name>A0A132PLW7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850487.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16765"/>
    <dbReference type="EnsemblBacteria" id="KWX23340">
        <property type="protein sequence ID" value="KWX23340"/>
        <property type="gene ID" value="AFM11_16160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7357"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453121" evidence="2">
        <location>
            <begin position="32"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="34579" checksum="AEBD17250CFC25CC" modified="2016-06-08" version="1">MQTVIVIGVMSPLNLRTLAAGLVLVAPLALAACGSDESSTAEPAGDCPTTPVDVVVSVDQWGDIVSELGGACAKVTTVLAGSSVDPHDFEPSPSDAAKFEGAQLVVINGGHYDEWAAKLAESSAPNAPIVAAIEDAGAHEGETHDHGHEEEGHDHGEGTNPHAWYSPAAVTSVADAVTAQLGELAPDAKDYFAQRRTAFTDSMKPYNQLIDDIKTNASGKTYAATEAVFDDMAAAVGLVNRTPEGYQVASSNESDPSPADLDAFLRLLADKGVDVLIYNTQTEGSVPQQIRSAAEAAGVPVVDVTETVAPGTDSFEAWQVDQLTSLAKALGVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMC4</accession>
    <name>A0A132PMC4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849854.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18300"/>
    <dbReference type="EnsemblBacteria" id="KWX23491">
        <property type="protein sequence ID" value="KWX23491"/>
        <property type="gene ID" value="AFM11_14525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7013"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="248" mass="25445" checksum="BDD9B366FCCF8AA0" modified="2016-06-08" version="1">MAQLEGKTALITGGTSGIGYATARAFADEGAKVFITGRTQQRVDAAAASLGSGVVGVASDVTSTEDLDRLVGVIRGAGAGLDIVFANAGSGEFATLEDETPEHLIDTFNRNVGGTVFTVQKTLPLLNPGASIILSGSTAATRGTPAFGAYAAAKAAIRSFGRTWATELGDRGFRVNTVIPGPILTEGLTELVPDKDQRQAFFDGLATNPMKRLGEPAELAAVVVFLGSDASSFMTGAEIFVDGGMNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMM6</accession>
    <name>A0A132PMM6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850057.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09260"/>
    <dbReference type="EnsemblBacteria" id="KWX23588">
        <property type="protein sequence ID" value="KWX23588"/>
        <property type="gene ID" value="AFM11_14140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6932"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007403">
        <property type="entry name" value="DUF456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04306">
        <property type="entry name" value="DUF456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="161" mass="16714" checksum="A3C79808FCC4700D" modified="2016-06-08" version="1">MSTLGIVLVALAIAIGLIGIVVPILPGGLLVFAAIAVWAVVEHNTASWITLGVATVLFVAAEVIKYLWPVRRMRAAEVRTLSLVAGAVLGIVGFFVIPVIGLVIGFVAGVYLAELGGRRDYRRAWASTVHALKGVALSVGVELVGALLATMAWVAGVFATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMR9</accession>
    <name>A0A132PMR9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848899.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02725"/>
    <dbReference type="EnsemblBacteria" id="KWX23615">
        <property type="protein sequence ID" value="KWX23615"/>
        <property type="gene ID" value="AFM11_12465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6583"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="164" mass="17791" checksum="5313971953FFCB73" modified="2016-06-08" version="1">MTITGTLDPRFSEATQPTEWPAAAEALTTAGLYWLTTVRADGRPHVTPLVGVWVDDTFVFCTGPSEQKARNLRSGAAVVVTTGANTWDAGLDVVVEGSAGRVTGRHELTALADAYRAKYGDDWDFDCDDEVFDPEGEAAIVYRVTPDKVLAFAKSPHGQTRFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNF3</accession>
    <name>A0A132PNF3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03815"/>
    <dbReference type="EnsemblBacteria" id="KWX23794">
        <property type="protein sequence ID" value="KWX23794"/>
        <property type="gene ID" value="AFM11_13570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6809"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="213" mass="22936" checksum="2A94B85C21420F2F" modified="2016-06-08" version="1">MWDQLFELDEARRASVRPRGLKRWRWLKPALIALAALLVVVAVVALVVWLLRPEPPSETTSGATESTETTDPQAQRRLAQLLPAGYSPDACTPAAPSAPDAIATVTCGENTDPSGPPRATYTLLSDKAALSDAFDQVVASSTTVVCPGRIQSPGPWRRNATPDQVSGILFCGTQQGRPMVAWTDEASMVLSQVHADEAGPTFPELYAWWSSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNN3</accession>
    <name>A0A132PNN3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside 2'-N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11220</name>
        <name evidence="3" type="ORF">AWC31_30675</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30675"/>
    <dbReference type="EnsemblBacteria" id="KWX23940">
        <property type="protein sequence ID" value="KWX23940"/>
        <property type="gene ID" value="AFM11_11220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12359">
        <property type="protein sequence ID" value="ORX12359"/>
        <property type="gene ID" value="AWC31_30675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6321"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX12359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="191" mass="20832" checksum="145AD1C4797174EB" modified="2016-06-08" version="1">MVSPNTYAPHVRGVLHTARLVHTSDLDHETREGAHQMVIDAFDGDFTDADWEHSLGGMHALICHHGALIAHGAVVQRRMLYRDIALRCGYIEGVAVREDWRGQGLGTAVMDALEQVLRGAYQLGALSASDVGRQMYTSRGWLPWQGPTSVLAPSGLVRTAEDDGGVFVLPMGIELDTTAAIACDWRDGDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNP0</accession>
    <name>A0A132PNP0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_13655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849464.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23807">
        <property type="protein sequence ID" value="KWX23807"/>
        <property type="gene ID" value="AFM11_13655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6827"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="444" mass="46744" checksum="A272CFFEF1623684" modified="2016-06-08" version="1">MSDDALSMRGPIHGTPEAKRVAIGSGVGAVIETYDFIGFGTAAALYFGTAFFPNSSPVAGTLAAFATLGVGFAARPLGGIIGGHLGDKVGRKPVLVASLIIMGLATFAIGLLPTYAAVGVLAPVLLVTVRIIQGLAFGAEWGGAILMSYEHAPWKQKGRYTGIVQAGFPVGLLLANLVFLVSVHLGGDWAWRVPFLASIVLVIVGLIIRARVPESPVFEDVKQTGKIVKAPIVEVFKTDWRNILRGIGLRVAETAGYAVSITYMISYLKSAKLATATETLVALCIASAVGIFATVAWARLTDRVGRRPVYLWVCAFGIPFGVLMFMLVNTGLFLLIVATFIVSYGVSQNALAGAQGAWFPELFTANTRASGASLAYQISAMVSGFTPFITTLLYEAFGWVGPALLFSAYAAIGLWAAIVTRETWGPRERALADKAAANAHALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNR4</accession>
    <name>A0A132PNR4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30600"/>
    <dbReference type="EnsemblBacteria" id="KWX23955">
        <property type="protein sequence ID" value="KWX23955"/>
        <property type="gene ID" value="AFM11_11295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6336"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="82" mass="9580" checksum="3C6CE25C44B2E869" modified="2016-06-08" version="1">MLRRFRIRGLGYETRVGSTQQPITVERQLMSMGHTHSVNDIRTAIRELSTRAQLARKEGRTADANEIEERIARYREELAQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP38</accession>
    <name>A0A132PP38_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_12130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848610.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09845"/>
    <dbReference type="EnsemblBacteria" id="KWX24100">
        <property type="protein sequence ID" value="KWX24100"/>
        <property type="gene ID" value="AFM11_12130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6505"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="47"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="431"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="754"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="849"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="863"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="901"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="921"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="954"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="982" mass="105699" checksum="7E7EB19A8C5D9DD3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPA2</accession>
    <name>A0A132PPA2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848618.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09825"/>
    <dbReference type="EnsemblBacteria" id="KWX24104">
        <property type="protein sequence ID" value="KWX24104"/>
        <property type="gene ID" value="AFM11_12150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6509"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021414">
        <property type="entry name" value="DUF3054"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11255">
        <property type="entry name" value="DUF3054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="122" mass="12864" checksum="EC072DDA8F73A0DA" modified="2016-06-08" version="1">MRRTSTLSLLTDVVCVVVFCTIGRRSHDEGITVAGVAETAWPFLVGTGVGWLVSRGWQRPTSLAPTGIAVWVCTVVIGMLLRKLTSAGVAASFIVVASLVTGVLLLGWRAALTGVRRRAQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPR5</accession>
    <name>A0A132PPR5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847261.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24264">
        <property type="protein sequence ID" value="KWX24264"/>
        <property type="gene ID" value="AFM11_09735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5985"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009594">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06719">
        <property type="entry name" value="AraC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="193"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="303" mass="33036" checksum="9868BE2872461EF5" modified="2016-06-08" version="1">MRARIDPLSEMCRRIDRHARPDMGTSIHGLLLSKVRGSASPDYSLTEPLLVVMAQGGKRLHLGEEVFEYRAGQYLLVAASLPVTGHYLGAPTQASLAMGLVLRPAALATLMLQAGSDLPARVAGSGPAIATGDADPDLLDAVARLLALLDRPRDAPVLAPLIEQEILWRLLTGPHGDTVRQIGLADSYLTQVNRAIGWMRDNYAAPVRIEDLARMSGMSTSAFHRHFRAVTAMSPLQFQKRIRLQQARSLLVARPGDIAGVGHEVGYESPSQFTREYRRLFGAPPGADAARLRDDPPRRNYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPZ3</accession>
    <name>A0A132PPZ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847612.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24373">
        <property type="protein sequence ID" value="KWX24373"/>
        <property type="gene ID" value="AFM11_10420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6123"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="162" mass="18259" checksum="20687BF8D22C0C76" modified="2016-06-08" version="1">MSKQFALNLVGEFAVYRDMKPLVLPPSCRRVVALAAVKRRELHRSWVCATLWPYSPPAKAVASLRSALWRLRPLGADPLLVVNRHHLALAPHVWVDWHEALHLAERMSPDSDPRLRRLLGDGDLLDDWTEPWCVTERARFRALKQAALASPAIGHPNCGAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ30</accession>
    <name>A0A132PQ30_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_10810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847815.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19325"/>
    <dbReference type="EnsemblBacteria" id="KWX24439">
        <property type="protein sequence ID" value="KWX24439"/>
        <property type="gene ID" value="AFM11_10810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6201"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="235"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="319"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="495" mass="52387" checksum="F7DB1A5EBF0EA58D" modified="2016-06-08" version="1">MGAIRLSVRYAAGLIYAQITAAAAVTLVVVALSRNTIGDVRQLLTEANLIALVALMTAAAIVDTVVGYVNIYPTFKWFAAGRHPTPRQQRAAMRIGPRQTIIQFSTWAVSAVVYTVVNLDLGGGVAYVMGGAILFGGVAAACMGFLVTQRMLRPIVAASLTTASAAQVTMPGILGRLITIWVLFSGLPTVGIAMIVLARSNGWFVQKTAPVEAAVLVLAVMSLLFGLRSMVLVARSISDPVREVVLGMKAVEKGWSAVSVKVYEPSEIGRLQYGFNRMVSGLAERNRLRDLFGRYVGADVARHALEQGGAVSGDVREVAVLYVDLVGSTALGASRPPQEVAELLNGFFRIVVDTVERHHGLINKFEGDAILAVFGAPLRLDNAASSALVTGRALVPRLRELPDVEFGVGISCGSVFAGNVGAENRYEYTVIGDAVNEAARLADHAKDRESAVLCSGSALASADADEGQHWTVRGSTVLRGRSTATVFAEPLPQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ59</accession>
    <name>A0A132PQ59_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847902.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05915"/>
    <dbReference type="EnsemblBacteria" id="KWX24470">
        <property type="protein sequence ID" value="KWX24470"/>
        <property type="gene ID" value="AFM11_09310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5899"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="9"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="304" mass="31532" checksum="D292A57EE7520BE6" modified="2016-06-08" version="1">MRAIVYDPQAPANLRLDEVADPPVADSQALIDVHAIGLNFGEVHFIDQMRKPGEVPGWDSAGVVVQAAADGSGPGVGTRVVGFSGEAGWAQRRAVATENLTELPEFVEFEEAAALPVAGVTALQALRALGPIVGRRVLITGASGGVGRFAVQLAARAGAHVVAAVGSAPRGEGLTELGAAEVVVGLAGVTEPVYGVLDNVGGKLLAQAFSLVADGGSVQSIGMASNEPTTIDFEHERRLGNRKRLEPFTVRAPFAADLQYLLTLLADGELDPQIGLRDSWENVASAAQALLDRKVAGKAVLRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQD3</accession>
    <name>A0A132PQD3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846000.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22050"/>
    <dbReference type="EnsemblBacteria" id="KWX24533">
        <property type="protein sequence ID" value="KWX24533"/>
        <property type="gene ID" value="AFM11_07550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5358"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="398" mass="43621" checksum="8F17321F663FCE6B" modified="2016-06-08" version="1">MKVNLGTGAQNSHDWDRVLAGDFSTPPATPDYKCVQAALALGDLAEPLGFDGIWFPEHQGTPYGMTPNPIQALTYFAARTERVSLGTFVAVAPWWHPVRLAHQIAYLDIVSNGRYTTIGLGRGVSKSEFDAVGVPREESRQRFNETLDVLKLAFSGERFSYDGEIFKFPEMSLRPEPLSTDLFDRIYSSSSTPESLEILARRGMVPLFVGNKPIWDAGEEVKKVNTFRAEEGLPPCQPKNVMFMYCVASEDDVPKTEEWIYTANRDVTVHYGFADASNFKGVKGYEAYANREGSATALLAESVQGDGTGGPKPGDKKGPPGYHASNLLIGTPEEIFKRLKAAQEACSFSEVTIVPQFGTMPYEDAMESVRLFAAEVLPAVHDMEAPLHPAVLPEGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQK1</accession>
    <name>A0A132PQK1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846206.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24606">
        <property type="protein sequence ID" value="KWX24606"/>
        <property type="gene ID" value="AFM11_07955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5441"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="104" mass="11760" checksum="63B99E9E58979732" modified="2016-06-08" version="1">MGDVFKALADPTRRTILDELTERDGQTLFEICARLLTNHGLSSTRQAVSQHLDVLEGAGLIETRREGRYKFHHINTAPLEPIVERWLKQPRDKHTETDGGEGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQK6</accession>
    <name>A0A132PQK6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_07840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846149.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24450"/>
    <dbReference type="EnsemblBacteria" id="KWX24585">
        <property type="protein sequence ID" value="KWX24585"/>
        <property type="gene ID" value="AFM11_07840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5419"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000366">
        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00250">
        <property type="entry name" value="GPCRSTE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="49"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="364"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="416"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="626" mass="66433" checksum="2E6FC43ABE3F4F60" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR41</accession>
    <name>A0A132PR41_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1,4-beta-xylanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08905</name>
        <name evidence="3" type="ORF">AWC31_13465</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846676.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13465"/>
    <dbReference type="EnsemblBacteria" id="KWX24765">
        <property type="protein sequence ID" value="KWX24765"/>
        <property type="gene ID" value="AFM11_08905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18325">
        <property type="protein sequence ID" value="ORX18325"/>
        <property type="gene ID" value="AWC31_13465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5630"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453256" evidence="1">
        <location>
            <begin position="32"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="378" mass="42635" checksum="756033D25220A633" modified="2016-06-08" version="1">MHRRTALKIPLVLAASMALPQALSTLPRASAAPGQWPVERANAWYQAQGWLVGTNFITSNAINQLEMFAPGTYDPRRIDSELGACRLLGFNTVRVFLHDLLWAQDRGGFQRRLAQFVSIAARQGIKPLFVFFDSCWDPNPKLGAQRAPTPGVHNSGWVQSPGAERIDDPRYRPLLRDYVIGVMSQFRTDNRVLGWDLWNEPDNPAKQYRSVERKDKIDLVGGLLPQVFGWARSVDPVQPLTSGVWQGSWGPGSRSEMDNFQLDNSDVISFHSYGGPSDFEARIAELAPYGRPILCTEYLARNEGSTIEGVLPIAKRHNVGAYSWGLVAGKTQTYFPWDSWDKPYTEVPKVWFSDLLRPDGRPYRDAEYQTLRKLTARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR50</accession>
    <name>A0A132PR50_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13205"/>
    <dbReference type="EnsemblBacteria" id="KWX24810">
        <property type="protein sequence ID" value="KWX24810"/>
        <property type="gene ID" value="AFM11_09165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5682"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="3">
        <location>
            <begin position="674"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="789" mass="85055" checksum="E64B750DFC3678DC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR72</accession>
    <name>A0A132PR72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_09265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846872.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13105"/>
    <dbReference type="EnsemblBacteria" id="KWX24823">
        <property type="protein sequence ID" value="KWX24823"/>
        <property type="gene ID" value="AFM11_09265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5701"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="79"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="305" mass="32810" checksum="A7200399E4FE4B1A" modified="2016-06-08" version="1">MAAAEPAGRASPPTARVVAILDFLARHPHDRFGLSELARRVGLSKPTCLGILTTLTDSGYLVRQAGENGRDKSYRLGPALISLGHVAQESMRVNPAGQAELRKISAAFDTTAAISAVVDDRITVLELVGPPGSDVGVRIGQSYPFAPPVGLMFVLWDEAALRSWLAKAPTVPLRTESDRLAQVVAECRTAGYLVERLTPAGQRLYGLMAGMSSTLPDELQVLLRELISDIGERVYLRSEAQTRGRHDVSVISAPVYDHHHRQVMVVSLHIGRALTDTEITQRARGVVACADSLTAQLRGSKPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR77</accession>
    <name>A0A132PR77_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08550</name>
        <name evidence="4" type="ORF">AWC31_13815</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003884652.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13815"/>
    <dbReference type="EnsemblBacteria" id="KWX24707">
        <property type="protein sequence ID" value="KWX24707"/>
        <property type="gene ID" value="AFM11_08550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18384">
        <property type="protein sequence ID" value="ORX18384"/>
        <property type="gene ID" value="AWC31_13815"/>
    </dbReference>
    <dbReference type="GeneID" id="44295762"/>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5559"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010814">
        <property type="entry name" value="DUF1416"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07210">
        <property type="entry name" value="DUF1416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="100" mass="10062" checksum="846C8A7B283A364D" modified="2016-06-08" version="1">MCSAPKQGLTLPAGVDLEKETVITGRVVDGSGQAVGGAFVRLLDSSDEFTAEVVASATGDFRFFAAPGTWTLRALSPAGNGDASVAPTGAGIHEVDVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR95</accession>
    <name>A0A132PR95_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846921.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24395"/>
    <dbReference type="EnsemblBacteria" id="KWX24572">
        <property type="protein sequence ID" value="KWX24572"/>
        <property type="gene ID" value="AFM11_07770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5405"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="48"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="453"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="561" mass="61584" checksum="7435F545BFB1C890" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRG8</accession>
    <name>A0A132PRG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09025</name>
        <name evidence="2" type="ORF">AWC31_13345</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846743.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13345"/>
    <dbReference type="EnsemblBacteria" id="KWX24787">
        <property type="protein sequence ID" value="KWX24787"/>
        <property type="gene ID" value="AFM11_09025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18304">
        <property type="protein sequence ID" value="ORX18304"/>
        <property type="gene ID" value="AWC31_13345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5655"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="63" mass="6933" checksum="DB0B4D59A5E4F267" modified="2016-06-08" version="1">MRVEVDRDRCEGNAVCVGIAPDLFDLDDEDYAVVKADPVPADQEELAEQSVAECPRAALIRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRJ8</accession>
    <name>A0A132PRJ8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="7" type="ORF">AFM11_05950</name>
        <name evidence="8" type="ORF">AWC31_29710</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845156.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29710"/>
    <dbReference type="EnsemblBacteria" id="KWX24978">
        <property type="protein sequence ID" value="KWX24978"/>
        <property type="gene ID" value="AFM11_05950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13937">
        <property type="protein sequence ID" value="ORX13937"/>
        <property type="gene ID" value="AWC31_29710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4382"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="187"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="192"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX13937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="414" mass="43203" checksum="DD117D5AAE89B9B2" modified="2016-06-08" version="1">MSARKRIVVGVAGGIAAYKACTVVRQLTELGHSVRVVPTESALRFIGAATFEALSGNPVHTGVFDDVHEVPHVRIGQEADLVVVAPATADLLARAVAGRADDLLTATLLTARCPVLFAPAMHTEMWFHPATRENVATLRRRGSVVLEPASGRLTGADSGAGRLPEAEEITTLAGLLLERGDALPYDLSGVKALVTAGGTREPIDPVRFIGNRSSGKQGYAMARVLAQRGADVTLIAGNTAGLIDPAGVDVVHIGSATQLRDAVSKHAPGANILVMAAAVADFRPAHVATAKIKKGASEPSSIDLVRNDDVLAAAVRARADGELPNMRAIVGFAAETGDANGDVLFHARAKLKRKGCDLLVVNAVGENRAFEVDHNDGWLLSADGSEAALEHGSKTLMATRIVDAIAAFLQNHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRK5</accession>
    <name>A0A132PRK5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrR</name>
        <name evidence="6" type="ORF">AFM11_05890</name>
        <name evidence="7" type="ORF">AWC31_11750</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000002">
        <property type="protein sequence ID" value="ORX19238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845136.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11750"/>
    <dbReference type="EnsemblBacteria" id="KWX24966">
        <property type="protein sequence ID" value="KWX24966"/>
        <property type="gene ID" value="AFM11_05890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19238">
        <property type="protein sequence ID" value="ORX19238"/>
        <property type="gene ID" value="AWC31_11750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4369"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX19238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="185" mass="19997" checksum="85835B12FCBFFBC1" modified="2016-06-08" version="1">MGSSGTDRELLSAADVGRTISRIAHQIIEKTALDDPAERARVVLLGIPTRGVILATRLADKINEFAGVELPHGALDITLYRDDLNFKPPRPLASTSIPAGGIDDAVVILVDDVLYSGRSVRSALDALRDIGRPRSVQLAVLVDRGHRELPIRADYVGKNVPTSRSESVHVLLTEHDDRDGVVISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS08</accession>
    <name>A0A132PS08_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_06885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845480.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28765"/>
    <dbReference type="EnsemblBacteria" id="KWX25138">
        <property type="protein sequence ID" value="KWX25138"/>
        <property type="gene ID" value="AFM11_06885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4576"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="276" mass="28546" checksum="EEFDF87871BC5C6A" modified="2016-06-08" version="1">MTAVGELETSKLAALVATAAEILDAAAVPFVTGHRADSAVRKQGNDFATEVDLAIERQVVRALTEATGIGVHGEEFGGEPIDSSLVWVLDPIDGTFNYAAGSPMAAILLGLLADGEPVAGLTWLPFMGQRYSAIVGGPLEDNGVARQPLGSPTLADSIIGIQTFNIDSRGRFPGRYRAAVLANLSRVCSRVRMHGATGVDLAYVGAGILGGAISFGHHIWDHAAGVALVRAAGGIVTDLAGEPWTVDSKSALAAAPGVHEKMLEIVKSAGNPEDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS57</accession>
    <name>A0A132PS57_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein rarD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_06700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845400.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28975"/>
    <dbReference type="EnsemblBacteria" id="KWX25104">
        <property type="protein sequence ID" value="KWX25104"/>
        <property type="gene ID" value="AFM11_06700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4539"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="10">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="10">
        <location>
            <begin position="150"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX25104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="33528" checksum="B7D20D4039596E3A" modified="2016-06-08" version="1">MSDRRRSGLLFGTGAYTWWGLCPGFFLLLLPAGPLEILAHRIVWSAVFLFLVVVVARRLGDLRRLGGRTWLQLALASALVSVNWGVYIYAVTHAHVVDAALGYFINPLLSVALGVLVFRERIARWQLVALLLAVAAVVLLTVEVGAPPYIAFALAFSWAFYGLVKKVVVADPRVSVAVETLIALPIAGGYLVALQVLGQANFVNHGTGHALLLLLAGPVTAIPLLLFAAAAQRLPLVTLGLLFYLNPALQMAWGVLIGHEPMPVGRWIGFALIWLALAIMAVEALARRSRRSEDSASETVDRVEPESSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSA2</accession>
    <name>A0A132PSA2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844991.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12830"/>
    <dbReference type="EnsemblBacteria" id="KWX25231">
        <property type="protein sequence ID" value="KWX25231"/>
        <property type="gene ID" value="AFM11_05455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4280"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033294">
        <property type="term" value="F:ectoine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051470">
        <property type="term" value="P:ectoine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014337">
        <property type="entry name" value="Ectoine_EhuB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02995">
        <property type="entry name" value="ectoine_ehuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="2">
        <location>
            <begin position="46"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="294" mass="31207" checksum="6E7C1D3F8009D3D7" modified="2016-06-08" version="1">MSWTRRDFLRAGGAFALGAPALLASCSKVPQAGDGGTLQRIKDAGAIKIGIAGEVPYGYTQNGTVTGEAPEVAKAVFKAMGIDRVDATQVEFGQLIPALNASQYDMVAAGMAILPDRCQNAQFSAVDYLTPTALLVPRGNPQRINNFDDVKAQGVALAVLSGTVEEAVAKDLGIPPGNIQSYRGQPEMFQALRDQRAYCGALTDISLRRMLADNPGAPLEVTKGFVPVVDGQEQIQAGGFVFRKGDDELVEQFNTELKKLQDSGAWLDIVAPFGFTADNQVPEDVTTEKLCAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSY4</accession>
    <name>A0A132PSY4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Divalent metal cation transporter MntH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mntH</name>
        <name evidence="5" type="ORF">AFM11_03190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">H(+)-stimulated, divalent metal cation uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843876.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21905"/>
    <dbReference type="EnsemblBacteria" id="KWX25307">
        <property type="protein sequence ID" value="KWX25307"/>
        <property type="gene ID" value="AFM11_03190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2512"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="408" mass="42838" checksum="8B8063114A35BD44" modified="2016-06-08" version="1">MLEDTKVRTRPSWLLLGPAFVAAIAYVDPGNVAANISAGAQFGFLLVWVIVVANAMAGLVQYLSAKLGLVTGRSLPEAVADHTRTPSRIAYWVQAELVAMATDLAEVVGGAIALYLLFDLPLLIGGVITGVVSLLLLAVQNRRGQQMFERVISGLLLVIAIGFLTSLFVETPPAAAVAEGLIPRFEGAESILLATAMLGATVMPHAVYLHSGLARDRHGHPDAGPRRRMLLRVTRFDVGIAMVVAGAVNLSMLLVAATNLQGRDNTDSIEGAHAAVRDTLGPTVALLFAIGLLASGLASTSVGAYAGAMIMQGLLKRYYPLLLRRLVTLIPALVILAIGVDPSRALVLSQVVLSFGIPFALIPLVRLTSNKALMGADANHRVTTALGWAVAGLISVLNVVLIYLTVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSY7</accession>
    <name>A0A132PSY7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844108.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21535"/>
    <dbReference type="EnsemblBacteria" id="KWX25374">
        <property type="protein sequence ID" value="KWX25374"/>
        <property type="gene ID" value="AFM11_03620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2599"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TLP1_add_C" evidence="1">
        <location>
            <begin position="421"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="508" mass="53901" checksum="F27506D0F82DBFD2" modified="2016-06-08" version="1">MVDPRTPVIVGVGQFTERIDDPGYRGMSSVELATEAAKAALHDCGADIDAVARAIDTVAGVRQFEISGPTPPPFGASNNYPRSVARRVGAEPARAILEVIGGQGPQHLVTEFAAAIAAGDSDVVLLFGSDAVSTERYFAKRDDKPDFTETIDGQLEDRGFGYDGIFDEYTVKHGLIGAPVQYGLLENARRARLGLSVADYRQAMAELFAPFSKVASKNPFSAAPVERSVEELATVTDSNRMICDPYPRLMVARDQVNQGAATLLMSVGTARQLGVPDEKWVYLRGHADMKEQKLLERADIGASAVAVTAVNEALRVAGIGLDDVAAFDLYSCFPFPVFNICDGTGLATDDPRGLTLTGGLPFFGGPGNNYSMHGIAEAVNEMRDKPGQFALVGANGGIASKYSVGIYSTEPADWAPDNSADLQQHVAALPAVSITENAHGAATIETYTVRYDWPVRTGIIIGRLDSDGSRFLAKTKDEDLVGLLSDGDPLGAAIVVRSGDKGNRASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTB5</accession>
    <name>A0A132PTB5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol S-conjugate amidase</fullName>
            <ecNumber evidence="2">3.5.1.115</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mca</name>
        <name evidence="3" type="ORF">AFM11_04815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate</text>
            <dbReference type="Rhea" id="RHEA:36543"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58718"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:59633"/>
            <dbReference type="EC" id="3.5.1.115"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MshB deacetylase family. Mca subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.115" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844637.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20330"/>
    <dbReference type="EnsemblBacteria" id="KWX25563">
        <property type="protein sequence ID" value="KWX25563"/>
        <property type="gene ID" value="AFM11_04815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2844"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010127">
        <property type="term" value="P:mycothiol-dependent detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01482">
        <property type="entry name" value="Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03446">
        <property type="entry name" value="mycothiol_Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="32693" checksum="164220077FB51BFF" modified="2016-06-08" version="1">MSELRLMAVHAHPDDESSKGAATTARYAAEGARVMVVTLTGGERGDILNPAMDLPEVHGRIHEVRRDEMAKAAEILGVEHHWLGFVDSGLPEGDPLPPLPEGCFALVPLAEPVERLVRVIREFRPHVMTTYDENGGYPHPDHIRCHEVSVAAYEAAADHLLYPDAGEPWAVSKLYYNHGFLRQRMQLLQDEFAKHGQQGPFAKWLEHWDPDHDVFANRVTTRVECSQYFSQRDDALRAHATQIDPKGDFFHAPIEWQQRLWPTEEFELARSRVPVSLPEDDLFTGIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTL3</accession>
    <name>A0A132PTL3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_03065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25653">
        <property type="protein sequence ID" value="KWX25653"/>
        <property type="gene ID" value="AFM11_03065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2482"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="317" mass="31756" checksum="6D7DDE1E3A4849B9" modified="2016-06-08" version="1">MVRRRPRLALDGPAVIGAVTVALFVLACLFVPEFATANNLRALVLSVSLVGIVAVGLSLITIVGRMFSLSLSAVVATSAILFAATLHFGPWIALLLAVGFGITTGIVQGVLIGAARTDPIVTTIAASAIILGVAQLITGGVNVIGTGDSSVFGTLLVGAIPFQVVVFLVIAVGAALLHRYTALGREITLIGLNEKAAAVAGLRAWPRILAVFVISGALAALAGALLASESGQGNLMLGATYGFDAIIAVVIGGIGVKGGRGNPISAAVGALLVGLLANALVLIGLSYEDQLIFQGLLVLAAVVVTGATANASAARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTL5</accession>
    <name>A0A132PTL5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_04660</name>
        <name evidence="6" type="ORF">AWC31_20485</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844586.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20485"/>
    <dbReference type="EnsemblBacteria" id="KWX25537">
        <property type="protein sequence ID" value="KWX25537"/>
        <property type="gene ID" value="AFM11_04660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16430">
        <property type="protein sequence ID" value="ORX16430"/>
        <property type="gene ID" value="AWC31_20485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2811"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX16430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="240" mass="26447" checksum="80870ACE424642EC" modified="2016-06-08" version="1">MQHDVSSLIAPTDLGGGTVVSRIKEYILANRLSPGDPLPTENELSQQLNVSRSRIREAIKTLSALDIVEVRHGYGTYVGRLSFRAMVESLAFRGMLNAEDGLHVFAELVDFRELIETSLAGQIMERLTPQAALSMRRLTETMAEKAAQGQEFAAEDREFHLLLMETTGALAVGMTGAFWDVHALASRAVGPPDDLQATVNAHVAILDAIEMGDAEQLRAAIRAHYVPIRERMTRQRPGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTX6</accession>
    <name>A0A132PTX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_00370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842208.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33485"/>
    <dbReference type="EnsemblBacteria" id="KWX25786">
        <property type="protein sequence ID" value="KWX25786"/>
        <property type="gene ID" value="AFM11_00370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.75"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="458" mass="46591" checksum="35324112CA9C0F87" modified="2016-06-08" version="1">MTDVRSTTHPGSKPAGHDSGTPLGLAALLAGTVVGTVSNNVVNVPLDAIIDEFDAPLGNGVFVVVGFLVCFAATIPLAGWFGDRFGRRRVYCAALLATAVCAVGAATAPSLPLLIAWRSAGGVAAAAFAPAVMGLIAWMFSGERRGRAMGAWASANGIGQAVGPSLGGLVADTWGWRWVFVPLVPVALAGFAGTLRYVPRYRGVKMSFDLAGAAALTIGSALLMLALAVVSRPDVSGWLIAGTAAAAVAALAWFGWHCRRAESPFVDVRLISESRFVRSCLAAFAQMFCLGAMLLAVPLYLVGNSVSISAAGFVLFTVPAAMAVLGPGVGRWQDRLGPRRVLRTGLLLLLGAQVGMAVVVAQDRIVLPALIAVLVTGGIGIALVQTPAATGATRSPAGAQGTGLGLFNLVRFGGSACGAAWVAVALDVADYPAVFAACAVIVTLGLAGSFFGPDPQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTZ9</accession>
    <name>A0A132PTZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_00540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842293.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33655"/>
    <dbReference type="EnsemblBacteria" id="KWX25819">
        <property type="protein sequence ID" value="KWX25819"/>
        <property type="gene ID" value="AFM11_00540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.111"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="121"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="251"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="345" mass="36945" checksum="B6748C3FA842536B" modified="2016-06-08" version="1">MSLPMTNDNTAVSLVDVSTYLPGDAIGADYYAQFADSDDLRDNLMFRAPRFRHHVAPDETAIDMVERAAAGLIERHGADVVTGADVLITHTQLPDMPFYGGGGGMAHRLGMKPNWVIDLHNGGCAAFVLGLKLARNLLTSGEGHTALIAVAQNAAGQIFEQETIRRKAQASVPGDGAAVGLVTLSDSSPILDVECRTYGEYAGDMTISVDPPRKWWAAGPGEGCIGFTESKITKVLARGNRQVPEVSYAVCDRIGMQPKDVDLLVTNQPNRVFLRNWREALELPAERHVDTFDECGNLFAAGIPVNLDRAISDGRVKAGDTVLMSAFAHAGDFAGAAAVRWGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU18</accession>
    <name>A0A132PU18_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Aliphatic amidase</fullName>
            <ecNumber evidence="3 7">3.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Acylamide amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">amiE</name>
        <name evidence="9" type="ORF">AFM11_00655</name>
        <name evidence="10" type="ORF">AWC31_33765</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3 7"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842353.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33765"/>
    <dbReference type="EnsemblBacteria" id="KWX25839">
        <property type="protein sequence ID" value="KWX25839"/>
        <property type="gene ID" value="AFM11_00655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11651">
        <property type="protein sequence ID" value="ORX11651"/>
        <property type="gene ID" value="AWC31_33765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.134"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01242">
        <property type="entry name" value="Aliphatic_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023719">
        <property type="entry name" value="Aliphatic_amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX11651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="345" mass="38070" checksum="7F79C11CA76F6539" modified="2016-06-08" version="1">MRHGDISSSNDTVGVAVVNYKMPRLHTKAEVLDNARKIADMLIGMKSGLPGMDLVVFPEYSTQGIMYDEQEMYDTAATIPGDETAIFSAACREAGTWGVFSITGERHEDHPNKPPYNTLVLIDDKGDIVQKYRKILPWCPIEGWYPGDTTYVTDGPKGLKISLIICDDGNYPEIWRDCAMKGAELIVRCQGYMYPAKDQQVLMAKAMAWANNCYVAVANAAGFDGVYSYFGHSSIIGFDGRTLGETGEEEYGIQYAQLSLAAIRDARENDQSQNHLFKLLHRGYSGVHAAGDGDKGVADCPFEFYKLWVTDAQKAQERVESITRSTVGVADCRVGSLPVEQTIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU74</accession>
    <name>A0A132PU74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844721.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20190"/>
    <dbReference type="EnsemblBacteria" id="KWX25602">
        <property type="protein sequence ID" value="KWX25602"/>
        <property type="gene ID" value="AFM11_05040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2889"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="270" mass="27903" checksum="F4757BEB60B806D2" modified="2016-06-08" version="1">MNPFAGKQAIVTGAGSGIGAALCRALSGAGAQVLCTDIDGEAAARTGDALGARSARLDVTDAAAVQAAVDDVVERAGRLDLMFNNAGIVWGGDTELLTLEQWNAIIDVNVRGVVHGVAAAYPVMIRQGHGHIVNTASMAGLAAAGQLTSYVMTKHAVVGLSLALRSEAAAHGIGVLAVCPAAVETPILDKGAIGGFVGRDYFLQGQGVKTAYDADRLAADTLRAIERNKAILVKPRRAHASWVFARLAPGLMQRLSMRFVASQRAAQARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUF2</accession>
    <name>A0A132PUF2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25950">
        <property type="protein sequence ID" value="KWX25950"/>
        <property type="gene ID" value="AFM11_01340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.274"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="69" mass="7393" checksum="049AEB146ED6EFE3" modified="2016-06-08" version="1">MVLAKTIEVRDDLPRITAPTLVIKATLDRLATPAHSDELAAGIPGARLADLASGPPTNDELLQSHRRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUS7</accession>
    <name>A0A132PUS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842196.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33465"/>
    <dbReference type="EnsemblBacteria" id="KWX25782">
        <property type="protein sequence ID" value="KWX25782"/>
        <property type="gene ID" value="AFM11_00350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.71"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="787" mass="86484" checksum="EF2FD18FD46E2839" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUU4</accession>
    <name>A0A132PUU4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843181.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35060"/>
    <dbReference type="EnsemblBacteria" id="KWX26090">
        <property type="protein sequence ID" value="KWX26090"/>
        <property type="gene ID" value="AFM11_02280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.467"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="27318" checksum="78BDE96EA94BDA27" modified="2016-06-08" version="1">MTLDVAFPRPDIAVITLNRPDKLNALSYELVEGLHATLDDIAANNDCRVVVLTGAGRGFCSGLDLSAPNPPEAAGGTEFPRSGMRWQERIANLTVKLHRLRQPVIAAVNGPAYGGGFALAAASDIRLASESARFCTQFIKLGIGGCDIGVSYTLPRIIGAGPAFDMILTARTVDAAEALRLGLVSRVCANVVDDALEIAETLCGYGKFGLESTKQVLWANLDAGCLETALQVENRSQILASSGGGVAEFSEAFRRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUZ8</accession>
    <name>A0A132PUZ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_01600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842843.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25987">
        <property type="protein sequence ID" value="KWX25987"/>
        <property type="gene ID" value="AFM11_01600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.328"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="480" mass="49397" checksum="002B4C9E57637A13" modified="2016-06-08" version="1">MSIASPPHSRRWWALALIATAQFIVIMDTSIIGVALPRIQEDLGFSQENLSWVFNAYVVALGGLLLLGGRLSDLFGARRMFSAGWGILLLGSAVAGLAGNVGVELAGRAVQGAGAALIAPSALTLLMMFFGSDPRELTKALALYGAAAPAGGTAGVFLGGLITEYMSWPWVFFINIPVAVLALAAVPVLMPAGGARVRGTVDVTGAATVTAGLGATVYAIVRAPEVGWDSIETWGVLAISVVMLGIFIGVQASRREPLMRLSIFRTPNLGAANIAQLLLGGAWIPMWFFLNLYLQQVLGYSAFPSGAALLPMTILIMIGMIALAPRAINRFGPKTMIVGGLVILAIGMGWLSFVRPDGNFWADVLPASLVAALGMSLAFIPSLGTAISSAQPEEGGLASGIVNTSYQIGSALGLAAMTAVAASYGADRLGDPSALTDGFSSAFLGAGLIALAGAVIAALTLRTPQLESSVPDSESTAEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVQ3</accession>
    <name>A0A132PVQ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_02410</name>
        <name evidence="6" type="ORF">AWC31_35190</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843252.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35190"/>
    <dbReference type="EnsemblBacteria" id="KWX26112">
        <property type="protein sequence ID" value="KWX26112"/>
        <property type="gene ID" value="AFM11_02410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11890">
        <property type="protein sequence ID" value="ORX11890"/>
        <property type="gene ID" value="AWC31_35190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.494"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="222" mass="24578" checksum="5668A4308B8F2B36" modified="2016-06-08" version="1">MSPLDSAATITTPTGEPLSVRERVYRYLRQQITTGEYGGGIRLTEEEIAEDLGVSRTPIREALQRLTSEGLVERVRRGQLIVVEVDATARAELHELRVAFDQVAAKLITAKSAEVDWDSLYGMLTPLEAALHEYGVSSPQYAMAHLEFHMAINRAAFCPITSSFLERQAFLYPTDDYVQQSGHEPISQHRTLLDDLAGGDLERAATAMRVHALRGHGNTTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB91</accession>
    <name>A0A132PB91_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19580">
        <property type="protein sequence ID" value="KWX19580"/>
        <property type="gene ID" value="AFM11_35185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5766"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="184" mass="20547" checksum="958A6C4A19470B5B" modified="2016-06-08" version="1">MPLRTTNADRHPVSGGDLPTQHEEFPMAEQLMMDFDPQATAARTTADNEIAAAYATLVATAAVCEADARAQGLHMTSRQNDGRVTVLICPACGQYEANEFLIANNHGLHRSGLHKRHDGTWVTRGREFGRQWCLALDLTSRHAAAGAHLSPRQTRMVDRLRADVRARFEREVAELRQRLAERHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBE6</accession>
    <name>A0A132PBE6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_34860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859503.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11000"/>
    <dbReference type="EnsemblBacteria" id="KWX19638">
        <property type="protein sequence ID" value="KWX19638"/>
        <property type="gene ID" value="AFM11_34860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5321"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="31"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX19638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="487" mass="52919" checksum="6B15A1FDF1930987" modified="2016-06-08" version="1">MSQSSDLTAPEAASTPSSAEPRLDRQLSNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSVIFVYMIIGFMLFFVMRAMGELLLSNLHYKSFADFAADLLGPWAGFFTGWTYWFCWIVTGVADVVAISGYVSYWWGDLPLWIPALVTVGVLIGLNLPTVRAFGETEFWFALIKIVAIVALIVIGLVMVFRHFEAPNGAVASFANLWNDGGFFPTGPMGFVAGFQIATFAFVGIELVGTTAAEAKNPERNLPKAINSIPVRVMLFYVAALAVIISVTPWREISPDNSPFVAMFSLAGLGIAASVVNFVVLTSAASSANSGIYSTSRMVYGLAQEGDAPSRFGKLTSRRVPANALFLSGVFLLSGVVMVVVGDSIIEAFTIVTTISSLCFMFVWSIILISYLTYRKRRPALHEASKFKMPGGIVMCYVVLAFFVFLVWAFTQKQDTLQALLVTPVWFIVLGVAWTVLRRRPGHLAREAKFRADLEAAEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBN1</accession>
    <name>A0A132PBN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859316.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17260"/>
    <dbReference type="EnsemblBacteria" id="KWX19657">
        <property type="protein sequence ID" value="KWX19657"/>
        <property type="gene ID" value="AFM11_34535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5252"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="307" mass="33714" checksum="4DEDCBD8065E3925" modified="2016-06-08" version="1">MLSRPVSIGDEEIANVVAAHWLPQITDISYLPWGFGAYHWRANGGGTTLFVTLDHLEPRHTGSSLEAAYAGAAALAAAGLNMVCAPLPAESGQFTVGLGACALSVTPWLPGSSPTEAQAREPQHVREVVLALESLHRAVPPEGLRPWTPRVGLSFADELRTRTREPWTSGPLAEKARLALTAHIEQIQRWTERYLELAETACSRRDTWVPTHGEPHNENQVVTADGVRLVDWESLALAPRERDYADLPAAVHGLLRPDPAMLELFSLDWRLSEIAEYTRWFTAAHIGSEDDHTALEGLYEELTGGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBX7</accession>
    <name>A0A132PBX7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="11">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DHOdehase</fullName>
            <shortName evidence="11">DHOD</shortName>
            <shortName evidence="11">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrD</name>
        <name evidence="13" type="ORF">AFM11_33790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="11"/>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858882.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07965"/>
    <dbReference type="EnsemblBacteria" id="KWX19829">
        <property type="protein sequence ID" value="KWX19829"/>
        <property type="gene ID" value="AFM11_33790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5095"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="12">
        <location>
            <begin position="49"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="115"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="314"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX19829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="353" mass="36907" checksum="46BC5D7240008C81" modified="2016-06-08" version="1">MYGALRRAMFLMPAERIHTWVFALLRTATGPAALRRVLSRRLAPTDPILASTVFGVRFPGPLGLAAGFDKDGRGLNAWGALGFGYAEVGTVTAQPQPGNPEPRLFRLPDDHALLNRMGFNNAGAAALAARLASHTPDVPIGVNIGKTKVTPAEAAVSDYVTSTRLLSAHASFVVVNVSSPNTPGLRDLQAVASLRPILAAVKAETDKPVLVKIAPDLSDADIDEIADLAVELGLAGIVATNTTVSRDGLRTPGAADLGPGGISGRPVARRSAEVLRQLYRRVGDKLVLISVGGIETADDAWDRITSGASLLQGYTGFIYGGGLWAKDIHDGIAERLRRGGFASLADAVGSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC85</accession>
    <name>A0A132PC85_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858786.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02150"/>
    <dbReference type="EnsemblBacteria" id="KWX19914">
        <property type="protein sequence ID" value="KWX19914"/>
        <property type="gene ID" value="AFM11_33600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5053"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="20587" checksum="DB97F5B86C701DB6" modified="2016-06-08" version="1">MTRPTLRELASLPAAPARLADSTLVLIDCQNTYTQGTMELEGVQAALVEAAQLLDRARTAGIPIIHIQHSDGPGSLYDIEGESGAIVASVAPREGEPVVVKNFPNSFVQTDLQQRLQEVNASNLVLAGFMTHMCVNSTARGAFNLGYAPTVVAAATATRSLAGPDGEPVPASALQAASLAALSDLFAVVVPQTVDIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC88</accession>
    <name>A0A132PC88_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_33895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858930.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07490"/>
    <dbReference type="EnsemblBacteria" id="KWX19847">
        <property type="protein sequence ID" value="KWX19847"/>
        <property type="gene ID" value="AFM11_33895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5117"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="219" mass="23553" checksum="53174D8BBDDAEF1F" modified="2016-06-08" version="1">MRDVLVVDDDFMVAEIHRRFVERVDGFRAVGVARNGGEALTAATELRPDLILLDVYLPDMTGLEVLQRLRAEGNLVGVIMITAARELDTVRGALDGGAADYLIKPFEFDQLRAKLAAFAARADALAAEGGASQSMIDALFSGRSSATAPLPKGLGAETGRLVMDAVRAAGEVSAAECAELVGISRVSARRYLEHYLSTGALELRLQYGTGRPERRYRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCI1</accession>
    <name>A0A132PCI1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20051">
        <property type="protein sequence ID" value="KWX20051"/>
        <property type="gene ID" value="AFM11_32290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4787"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="63" mass="6803" checksum="EA87E35E665072A3" modified="2016-06-08" version="1">MPRPDKFGTVCARKGGVLERLAKSMPSFVSDTFNLEPGSAVELPVGSVRVNPDDPMSDWIIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCI4</accession>
    <name>A0A132PCI4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19692">
        <property type="protein sequence ID" value="KWX19692"/>
        <property type="gene ID" value="AFM11_34575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5260"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="71" mass="7305" checksum="A4F815B9A5A1CACC" modified="2016-06-08" version="1">MDLKRVGGRPRADGKPLAKVPLAVDHDHVTGAVRGLLCPSCNAGLGAFGDDPVRLAAAITYLRADLSPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCM0</accession>
    <name>A0A132PCM0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_32475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858106.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19610"/>
    <dbReference type="EnsemblBacteria" id="KWX20078">
        <property type="protein sequence ID" value="KWX20078"/>
        <property type="gene ID" value="AFM11_32475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4823"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="400" mass="45261" checksum="95F9F0B8206D3CAB" modified="2016-06-08" version="1">MTASATQNVYFDPYDVEINANPYPTFARLREEAPLYYNEQHDFYALSRFADVNKALIDHETFSSARGAIIELIKADIDIPSGALIFEDPPIHTTHRKLLSRMFTPRKINALEPKIREFCAQSLDPLVGAGKFDFITDFGAVMPMRVISALLGIPEDDQEMIRDHANEQLRTEAGKPMKAAREGLVDGSIFETYIDWRKNNPSDDIMTELLNVEFTDEHGVTRHLTREELLIYINVVAGAGNETTTRLIGWAAKVLAEHPDQRRQLVENPALIPQAIEELLRYEPPAPHVARYVTRDVEYYGRTVPEGSVMMMLIGAAVRDSRQFPPDGEVFDIHREPRQHLAFSVGTHFCLGSALARLEGRIALEEILKRFPEWEVDLDNAALSPTSTVRGWDSMPAFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCM2</accession>
    <name>A0A132PCM2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine synthase</fullName>
            <ecNumber evidence="9">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cysM</name>
        <name evidence="9" type="ORF">AFM11_32565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858146.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19700"/>
    <dbReference type="EnsemblBacteria" id="KWX20091">
        <property type="protein sequence ID" value="KWX20091"/>
        <property type="gene ID" value="AFM11_32565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4841"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="9"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="185"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="324" mass="34822" checksum="0287E6C8E1891202" modified="2016-06-08" version="1">MARYDSLLQALGDTPLVGLQNLSPRWDDGDDDTPHVRLWAKLEDRNPTGSIKDRPALRMIEQAERDGLLAPGATILEPTSGNTGISLAMAALLKGYNMICVMPENTSIERRQLLELYGARIIFSPAEGGSNTAVATAKELAAENPSWVMLYQYGNPANSDAHYYGTGPELFADLPEITHFVAGLGTTGTLMGTGRFLREHVPGVQIVAAEPRYGEGVYALRNIDEGFIPELYDADVLTTRFSVGSFDAVRRTRELVTREGIFAGISTGAVLHAALGMAAKAIKAGERADIAFVVADAGWKYLSTGAYAGSLDDAEDALEGQLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCN1</accession>
    <name>A0A132PCN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858028.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20054">
        <property type="protein sequence ID" value="KWX20054"/>
        <property type="gene ID" value="AFM11_32325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4793"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="31198" checksum="0603CF65D88AD782" modified="2016-06-08" version="1">MVGEPTAVKSPCRTVTNEEVDHLHEYGWVQLRSFVDPDVVSKMLSIARDKMGDDADSNPVQAAAAPETDGEDQGGGLAYFNVEQSAGLTDPVMRPLIDEVGKSASALQRRRAADGSVVGIRYYTDFFAPKLPSTKAARHGGNGPTAFHQDFITFSVDRSGGMTFWFPLEAYGPEAGTMSFVNTSHRAGVLGDYTTYGGGDALDAFPELRDLEMSPQLTYELGDISVHTHLTIHGAGANMMDRPRWAYLLVTQPADVCWNGSVTPNFDSSRMTQWQPLDDERFPLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCR9</accession>
    <name>A0A132PCR9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32585</name>
        <name evidence="3" type="ORF">AWC31_19720</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX17052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858155.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19720"/>
    <dbReference type="EnsemblBacteria" id="KWX20094">
        <property type="protein sequence ID" value="KWX20094"/>
        <property type="gene ID" value="AFM11_32585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17052">
        <property type="protein sequence ID" value="ORX17052"/>
        <property type="gene ID" value="AWC31_19720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4845"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018561">
        <property type="entry name" value="DUF2017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09438">
        <property type="entry name" value="DUF2017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2017" evidence="1">
        <location>
            <begin position="11"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="192" mass="20764" checksum="91FFDC70FD8B7CF6" modified="2016-06-08" version="1">MRKWKRVETANGPRFRSALAAHEAALLSSLVGSLVGMLDERESSGPTDELEAITGMKTGNPQPPQDATMKRLLPDFYRPQTEHPAGSGTAESLNSALRGLHEPAIIDAKREAAQRLLDTVPDGGGKFELSEDDAQAWASAVNDVRLALGTMLDIGPDGPDRLSPEHPMAGHLDVYQWLTVLQEYLVLGLMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD84</accession>
    <name>A0A132PD84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857652.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26350"/>
    <dbReference type="EnsemblBacteria" id="KWX20298">
        <property type="protein sequence ID" value="KWX20298"/>
        <property type="gene ID" value="AFM11_31725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4249"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="29183" checksum="D880DA03EDE85A5F" modified="2016-06-08" version="1">MTLADDGVTTEAVLYDVNDDGVAIITLNRPDRLNSWGADISAGVYAAFDRAEGDPDVRAIVLTGTGRGFCAGAYMGSMAALGESIDGDTDVSKIVGERHPHFLTTLRKPVIAAINGACVGIGLTHALMCDVRFAAAGAKFATAFPRRGLIGEYGITWILPRLAGWGAAADLLLSGRTFFAEEAAQLGLVKEVVPPEDLLPRTLEYAGDLARNCSPASMAVIKRQLYGDANDDVTDVSARAETLMHESMVRPDLIEGITAFFEKRPPNFPPLTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDC0</accession>
    <name>A0A132PDC0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857072.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26385"/>
    <dbReference type="EnsemblBacteria" id="KWX20320">
        <property type="protein sequence ID" value="KWX20320"/>
        <property type="gene ID" value="AFM11_30665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4034"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="296" mass="33772" checksum="47F12401E1AD4C9E" modified="2016-06-08" version="1">MHSSRHKTRHETIDVHGLDIFHRHAGDPDMPTVLLLHGYPNSSYAYRNLIEPLAESAYVVAPDLPGSGFSSAASGDAFDYTFANLADTVDAFLDTLGVETFFLFVTDFGTPVGYHLATRRPDRIRGLIVQNGNTHDEGLGPDWDAPKAYFADPTEENRAKLTEWMNFETTRYQYVGNQPERVACLYPPEGWHLDWERLSRPGITDIQFQIFSDYGSHIARFPAIRSYHRDHQPPCLLLWGRHDPFFDLNEIMAYNEVLESLEIHVFESGHQLLETHPHECADLIARFMLDVEAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDM8</accession>
    <name>A0A132PDM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857398.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26825"/>
    <dbReference type="EnsemblBacteria" id="KWX20430">
        <property type="protein sequence ID" value="KWX20430"/>
        <property type="gene ID" value="AFM11_31115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4127"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thump_like" evidence="1">
        <location>
            <begin position="322"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="400" mass="43428" checksum="7FCDF4FF6C536611" modified="2016-06-08" version="1">MVLQRDGHRSQAVVAFDSDAVAFLRSEAGRHALRQVAGYPLTGATLVSDIASLRTQFGDRVAVLVETVQLRRRAAAKFDDPSDWLFTDEALQQATAAPVAAHRAARLRGARVHDATCSIGSELVALRDTAEQLVGSDIDPVRLAMAANNVGGVDLCRADALRPITRDAVVILDPARRQGGRRRFDPRAYTPALDAVLETYRDRDMVVKCAPGIDFDQVEQLGFAGEIEVTSSGGGVREACLWSSGLTESGVRRRATVLDRGEHITDVEPDDCPVAPAGRWIVDPDGAVVRAGLVRHYAARHGLWQLDRDIAYLSGDRLPDGVRGFEVLEQLAYHERRLRTALAARSVGAVEILVRGIDVDPDALRARLRLRGNERLAVVIARLGSGAASRATAFICRPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE36</accession>
    <name>A0A132PE36_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29785</name>
        <name evidence="6" type="ORF">AWC31_25125</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856551.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20591">
        <property type="protein sequence ID" value="KWX20591"/>
        <property type="gene ID" value="AFM11_29785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14481">
        <property type="protein sequence ID" value="ORX14481"/>
        <property type="gene ID" value="AWC31_25125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3849"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX14481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="184" mass="20456" checksum="5087ED1C091AC1B4" modified="2016-06-08" version="1">MAGRRTDTRDKIRSVALDLFSTHGYDQTSIRQIAEQLGITKAAIYYHFSAKEDIVVSLSDDLRTGVDDILSWAAGQPPGKRTGREILRRYGAVLHGTGRAMTRFMNENYAAFNRLGIGTDLRYQFRAVADAMTAPDHDPLAVFHARQALLTMSWSVAMMGDLPLTDEQCNETALTIALGIYNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE98</accession>
    <name>A0A132PE98_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20547">
        <property type="protein sequence ID" value="KWX20547"/>
        <property type="gene ID" value="AFM11_29525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3795"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="108" mass="11690" checksum="859F30700958A9FB" modified="2016-06-08" version="1">MTRCIEFRDDDSGYLAWLAANQQGYVINIARSRNTSQARLHLASCRTIGNGTPMGSSWTGPYVKVCSQHRADIEQWAAETVGQSIDPCGTCCPTDVAAARPAATRLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEC1</accession>
    <name>A0A132PEC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20673">
        <property type="protein sequence ID" value="KWX20673"/>
        <property type="gene ID" value="AFM11_29030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3688"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="81"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="28896" checksum="6986AE2B4AEEC542" modified="2016-06-08" version="1">MRLAPVPVTTEEAELRAWLRRFSTDRPRWGWRRAARMARRAGWKVNHKRIRRLWRAEGLRVPQRRRKKRLTGIGVAVGAMSPIRPNVIWAMDFQFDTTADGRTLKMLNVIDEFTREALAIEVGRSIDADGVVDVLDRLALTHGAPHYVRFDNGPEFVAHAVSDWCRFNGAGSLFIDPGSPWQNAWIESFNGRLRDELLNAWRFDSLREARVIIEDWRADYNANRPHSAHGELTPEEFALQWPTTHQPQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEW2</accession>
    <name>A0A132PEW2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_27610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855623.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10140"/>
    <dbReference type="EnsemblBacteria" id="KWX20870">
        <property type="protein sequence ID" value="KWX20870"/>
        <property type="gene ID" value="AFM11_27610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3396"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="229" mass="24989" checksum="EC0DA57966665A54" modified="2016-06-08" version="1">MRVLVVEDEPYMATAIRDGLRLEAIAADIAGDGDTALELLSINSYDIAVLDRDIPGPSGDEIAERIVASGSGTPILMLTAADRLDDKASGFGLGADDYLTKPFDLRELVLRLRALDRRRAQSRPPVREVAGLRVDPFRREVYREGRYVALTRKQFAVLEVLVAADGGVVSAEELLERAWDENADPFTNAVRITVSALRKRLGEPWIIATVPGVGYRIDTGTGREGADRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEZ9</accession>
    <name>A0A132PEZ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_27905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10425"/>
    <dbReference type="EnsemblBacteria" id="KWX20916">
        <property type="protein sequence ID" value="KWX20916"/>
        <property type="gene ID" value="AFM11_27905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3455"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039561">
        <property type="entry name" value="Peptidase_M15C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13539">
        <property type="entry name" value="Peptidase_M15_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453002" evidence="2">
        <location>
            <begin position="30"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M15_4" evidence="3">
        <location>
            <begin position="165"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="245" mass="27004" checksum="4DC2D2EDFE12B918" modified="2016-06-08" version="1">MTTDRPTARRRCAAALIAVACLPLVQCSATPPQPPPTAVSPPPSPTTTTTTTTATTTTRQPVPATVHPVTVAELGTTWRPGCPARPEVLRRVELDYLGFDGRTHRGALVVHKDLVPEVITIFEELLRQRYPIEKMRTVDHYPRADDELSMRDNNTSAFNCRGIPGSRSWSLHAYGRAIDVNPLLNPYIGSGGVEPANAGPYVDRSRIDPGLLHPGDPAVLAFTDRGWQWGGLWRSPIDYQHFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF32</accession>
    <name>A0A132PF32_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855847.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10650"/>
    <dbReference type="EnsemblBacteria" id="KWX20940">
        <property type="protein sequence ID" value="KWX20940"/>
        <property type="gene ID" value="AFM11_28105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3496"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="74" mass="8465" checksum="1E1BC7251FC5D410" modified="2016-06-08" version="1">MTTTDERHELGQLAESGGWQHRDLDRVDVYQRGTTRIRVVWQGSSAISGATLYHDDIMTTYTRDLAAVDGWLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFD9</accession>
    <name>A0A132PFD9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040641.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20712">
        <property type="protein sequence ID" value="KWX20712"/>
        <property type="gene ID" value="AFM11_29295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3745"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="30359" checksum="675F7059C81F6A51" modified="2016-06-08" version="1">MPGVDGRVAIVTGAGRGLGRSHALRLAAGGALVVANDLGVRKEGGGANAAAAQDVVAEIRAAGGVAVPDDHDIASETGAKEAVKSALEAFGRLDIVVNNAGILRDATFHKMTVQQWEAVRQVHLDGTAFVTRAAWPHLREQRYGRVVVTSSGAGLFGNFGQANYAAAKLGVVGLMHTLALEGARHGIRVNAVAPVALTRMTVGLLDDASDLDPAWVSAAVGWLCAEECDLTAEIVRVHGRHFSRVRIVESRGVDFPSPPSDDHLAARWAEIADLSGAQEGQAAVATARHAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFH1</accession>
    <name>A0A132PFH1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855902.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10775"/>
    <dbReference type="EnsemblBacteria" id="KWX20957">
        <property type="protein sequence ID" value="KWX20957"/>
        <property type="gene ID" value="AFM11_28225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3519"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="9"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="299" mass="31201" checksum="8179AB53094F993C" modified="2016-06-08" version="1">MEQDLLGLAFGAGLVAALNPCGFAMLPAYLALVVRGETTTRTPAALGRALLATVSMAAGFVAVFATFGALTIAAASTVQRYLPYITVVIGLILIGLGCWLLAGRHLGLLVPKALTRNRSWAPTARLGSMLGYGVGYALASLSCTVGPFLAVTGAGLKSATPLRGVSVFAAYAAGFALIVGVLAVAAALASTVVVDRMRRIVPYINRISGVLLVAVGAYVSYYGVYEIRLFTPAGNPQDPVIAAAGRIQGAVADWVHQHGAWPWMLILAGLVVLGLTWRLAIRYAERRRRARPATVADAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFP4</accession>
    <name>A0A132PFP4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RecBCD enzyme subunit RecD</fullName>
            <ecNumber evidence="10">3.1.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Exonuclease V subunit RecD</fullName>
            <shortName evidence="10">ExoV subunit RecD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Helicase/nuclease RecBCD subunit RecD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">recD</name>
        <name evidence="12" type="ORF">AFM11_28645</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.</text>
            <dbReference type="EC" id="3.1.11.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RecD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.5" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856205.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32875"/>
    <dbReference type="EnsemblBacteria" id="KWX20802">
        <property type="protein sequence ID" value="KWX20802"/>
        <property type="gene ID" value="AFM11_28645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3610"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009338">
        <property type="term" value="C:exodeoxyribonuclease V complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01487">
        <property type="entry name" value="RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006344">
        <property type="entry name" value="RecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041851">
        <property type="entry name" value="RecD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01447">
        <property type="entry name" value="recD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD_C_2" evidence="11">
        <location>
            <begin position="477"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX20802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="549" mass="58899" checksum="651921DC6CA426CE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFX4</accession>
    <name>A0A132PFX4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26815</name>
        <name evidence="4" type="ORF">AWC31_22520</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855108.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22520"/>
    <dbReference type="EnsemblBacteria" id="KWX21259">
        <property type="protein sequence ID" value="KWX21259"/>
        <property type="gene ID" value="AFM11_26815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15371">
        <property type="protein sequence ID" value="ORX15371"/>
        <property type="gene ID" value="AWC31_22520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3234"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX15371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="134" mass="14506" checksum="A8E731792D252766" modified="2016-06-08" version="1">MLRRADMRVTRPRVAVLGAVHTHPHADTDTIIRAVREELPDVSHQAVYDSLHALTAARLVRRIQPSGSVARYESRVGDNHHHVVCRSCGAIADVDCAVGAAPCLTASDDHGFSIDEAEVVYWGLCPECSTAPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGF4</accession>
    <name>A0A132PGF4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36035"/>
    <dbReference type="EnsemblBacteria" id="KWX21406">
        <property type="protein sequence ID" value="KWX21406"/>
        <property type="gene ID" value="AFM11_25860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3036"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="275" mass="29077" checksum="1365B5FA299EA312" modified="2016-06-08" version="1">MFISGASRGIGLEIAKRAAADGANIALVAKTAEPHPKLEGTIYTAAKEIEEAGGQALPIVGDVRDGDSVAGAVAKAVEQFGGIDICVNNASAINLGSIEEVPLKRFDLMNGIQIRGTYAVSQACIPHMKGRENPHILTLSPPIRLESEWLKPTAYMMAKFGMTLCALGIAEEMREAGIASNTLWPRTLVATAAVQNLLGGDEAMARARKPAVYADAAYAIFNKPAREYTGHSLLCEDVLLDNGVTDLSVYDCAPGSDLGVDLWVDTPNPPGYVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGI5</accession>
    <name>A0A132PGI5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hva1_TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_24905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854066.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27160"/>
    <dbReference type="EnsemblBacteria" id="KWX21459">
        <property type="protein sequence ID" value="KWX21459"/>
        <property type="gene ID" value="AFM11_24905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2342"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hva1_TUDOR" evidence="2">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="71" mass="7907" checksum="A0A6F3F4B3A3FE47" modified="2016-06-08" version="1">MSEEFRKGDKVSWQSHGATVPRTVVDKITTDTKTAGRQVRASAGEPQYRVRSDKTGRDAVHKPDALKRHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGN7</accession>
    <name>A0A132PGN7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate guanylyltransferase</fullName>
            <shortName evidence="1">PEP guanylyltransferase</shortName>
            <ecNumber evidence="1">2.7.7.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbiD</name>
        <name evidence="2" type="ORF">AFM11_24990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine</text>
            <dbReference type="Rhea" id="RHEA:30519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:143701"/>
            <dbReference type="EC" id="2.7.7.105"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CofC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.105" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854105.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27245"/>
    <dbReference type="EnsemblBacteria" id="KWX21473">
        <property type="protein sequence ID" value="KWX21473"/>
        <property type="gene ID" value="AFM11_24990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2359"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02114">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="PTHR40392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01983">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03552">
        <property type="entry name" value="F420_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="220" mass="22424" checksum="1D3294B359816271" modified="2016-06-08" version="1">MSGTRTASAAAATSGADVALIIAVKRLAAAKTRLAPIFSAPTREAVVLAMLVDTITAASSVAPVTVVTPDDVAADAARQLGAGVLADPTPQGHHDPLNNAITAAESELRASTPNIVVLQGDLPALQPQELAEALASARGYQRSFVGDRHGTGTSALFAFGVPLQPLFGADSAAHHRHSGAIELTGAWPGLRCDIDTPDDLQTARRLGVGAATSQAVARHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH65</accession>
    <name>A0A132PH65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_24350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853704.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21653">
        <property type="protein sequence ID" value="KWX21653"/>
        <property type="gene ID" value="AFM11_24350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2230"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="474" mass="48213" checksum="4FE208C8F8C759C1" modified="2016-06-08" version="1">MKDTLETAIHTREHRWSTRLVLWAAVLTLANVLADVVIGSPMMVLPQLLDHFDTDQAAWLNASAMLAGAIWSPLLAKTSDIFGKRRILVATLLLACVGALVCLGAPNVWIFLAGRFLQGAAFAAVFLTVALTRQICSPAVAMAVVGLLTSGSSLVGILEPFLMKPIIDSFGYRSVFVAAALLAAVSALCVRTLIPESPVRGTGRIDVIGAFLLGGGLGAVLAYITLGRDYGWLSSAMLTLLVAGLAALVGWTYLALRVDEPVIDIRSLSRPILLTLLALGLAAGAFRSMLQLTAIIAQVPGDLGLGYGLGDGETIAILLATPNLGIVVGGVGAGWIAGRTGPALPLLGGIVIGAVATSAMVAGVSVLPLAIVCGAMLGIAAGAIGASGYNLAVGAEPPERQGTVAGLVSVVLALGSVVFNVAGGEVLKATQIPGISAAGAPVSTATGVYLYVAVAAAFFILATVPATMLVRNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHT1</accession>
    <name>A0A132PHT1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852702.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08850"/>
    <dbReference type="EnsemblBacteria" id="KWX21918">
        <property type="protein sequence ID" value="KWX21918"/>
        <property type="gene ID" value="AFM11_22360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1822"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="65"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="150" mass="16290" checksum="931C843E2D68185C" modified="2016-06-08" version="1">MTTTDPLRTAGDPVAAARYAAEVAEPKFGQYFLIHFLGLSIDYLDDEHACTVHLPFAHHLCNAGGGVHGGVLSTVLDISMGHACNRYLSAGSTIEMQMRFLRPVTSDVSCTGRIVHGGRRVVQLESRMHDDAGRLVATANGSWFRHPTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI07</accession>
    <name>A0A132PI07_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4129 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_22800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852844.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08400"/>
    <dbReference type="EnsemblBacteria" id="KWX21989">
        <property type="protein sequence ID" value="KWX21989"/>
        <property type="gene ID" value="AFM11_22800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1913"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="229"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="309" mass="32107" checksum="7C9C21DAAB2D7B20" modified="2016-06-08" version="1">MPGIDKAAGRVATVLALVVVAAIALRGYVPGGQRAPAEARTDSPAGLVALIALLAVALAGFAFAVIAAPRKLDRPVGDAGLGRLELRGLQVRLRWRWALVALAALLWWLLVLVLITRLAEPDEPAPSSSPPASAPPGSPPQQPPDPVGGGDSALRYLAVASVILLLIVAFGTVVQARRRARPATWFDDGEHIASPPSPGGPETLARAAELGLAEIADLSRDPRTAIIACYAAMEHGLAQAPGAVPQDSDTPSEVLARAVSHHALSADSATELVELFTEARFSPHVMTEAHRDAAVAALHRVLADLRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI58</accession>
    <name>A0A132PI58_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mg2+ transporter-C (MgtC) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_22545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852757.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08660"/>
    <dbReference type="EnsemblBacteria" id="KWX21944">
        <property type="protein sequence ID" value="KWX21944"/>
        <property type="gene ID" value="AFM11_22545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1859"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="243" mass="25302" checksum="4FBC1AF2CE941711" modified="2016-06-08" version="1">MDLWLADPPFFGGPGQGTRQLIELFVAFGLTALIGLEREVQGKSAGLRTQTIVGTAAALILLVSKYGFSDVLAEGTVVVDPSRVAAQIVSGIGFLGAGIIIFRRGSVHGLTTAAAVWESAAIGMAAGAGLLLLACTVTVMHFVIVLGFMPLARRLAARLSGSVRMHVTYEEGRGVMRELLQACDRRQWQLTDLATDAPGEPLGADGRSGVVLTLSGSGILNAPTVLAAIDGVTAIHQLDEDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIW8</accession>
    <name>A0A132PIW8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein TIGR02206</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20925</name>
        <name evidence="3" type="ORF">AWC31_06345</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852126.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06345"/>
    <dbReference type="EnsemblBacteria" id="KWX22299">
        <property type="protein sequence ID" value="KWX22299"/>
        <property type="gene ID" value="AFM11_20925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09831">
        <property type="protein sequence ID" value="ORX09831"/>
        <property type="gene ID" value="AWC31_06345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1526"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011737">
        <property type="entry name" value="CHP02206_TP0381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09529">
        <property type="entry name" value="Intg_mem_TP0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02206">
        <property type="entry name" value="intg_mem_TP0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="227" mass="25786" checksum="1842CF3A7C89553B" modified="2016-06-08" version="1">MAQRQFTAYGPSYWAAIAVFAVVAALLVWLGRRQTEQQSRVLGRVLGVLTAAIYVAMLVYTLIPPSIERSVPLRLTDLATVVGAYAFWSQRQWAYELTYYWGLTLSAQALISPVLKSPDFPHYEFLAFWSIHLLVVWAAIYLTWGRGMRPSWRSYRFVVLVTAAWAAVTMAFNSFAETNYGFLNAKPATASLLDVLGPWPVYVLTASVLVLAVWALMTWPWERRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ04</accession>
    <name>A0A132PJ04_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852505.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04800"/>
    <dbReference type="EnsemblBacteria" id="KWX22167">
        <property type="protein sequence ID" value="KWX22167"/>
        <property type="gene ID" value="AFM11_21995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1747"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453387" evidence="1">
        <location>
            <begin position="34"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="35766" checksum="58098FDDAE21186E" modified="2016-06-08" version="1">MIFSRRRATAALACTAALVLAGCGGGDAENAPAAEGSATPATLMLNWYPYGEHAPFYYGVQEGIFAKHGIDLTIDAGQGSTKTVQAVGSQQADFGWADTPAVLTNIDKGVKVKSTGVFLQTTPSAVQVFADSGINEPKDLAGRTIAVSAGDAPTTTFPIYLDKVGVPADQVTQQSLDAAGKMSAMLSGRVDGLIGFAHDQGPTIANKSGREVRYLKYSDAGLNFYSNGLIANTETIGDKADLVQSMVDATSEAFTAAAANPEAAVQAMAGKDPQMPPQEVLLNQWQQTIPLLSTAATTNQPPGTNAEEDWTTTITTLTDAGLLKTAKAPAEYWESSFAPKPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ76</accession>
    <name>A0A132PJ76_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851842.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11125"/>
    <dbReference type="EnsemblBacteria" id="KWX22399">
        <property type="protein sequence ID" value="KWX22399"/>
        <property type="gene ID" value="AFM11_19785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1291"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="263" mass="27823" checksum="CCC7274AD0415D11" modified="2016-06-08" version="1">MTDISDAPRVRSSPFDLTGRTALVTGGNQGLGLAFAFGLAEAGAQVAIAGRSAERNEKVVSEAAAAGFAFHAITADITRAADVENMTADAISALGHLDILVNNAGTCYHGESWSVTEQQWDDVFDLNVKALWACSLAVGAHMRERGSGSIINIGSMSGMIVNRPQMQPAYNASKAAVHHLTKSLAAEWGPLGIRVNALAPGYCKTEMAPVDKPEFKRHWIDDTPMLRYAMPEEIAPSVVFLASDAASFITGSVLVADGGYTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ78</accession>
    <name>A0A132PJ78_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851833.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11080"/>
    <dbReference type="EnsemblBacteria" id="KWX22390">
        <property type="protein sequence ID" value="KWX22390"/>
        <property type="gene ID" value="AFM11_19740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1282"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="27849" checksum="38974D6F3B3B7B15" modified="2016-06-08" version="1">MIRIGTSGWSYDHWNGVLYPPGTPTAKRLDRYTEAFDTVELNASFYRWPKDTTFAGWRQRLPDGFTMSVKAHRGLTHYRRLRSPEPWIERFERCWTELGDRGEALLVQLHPAIERDDDLLAGFLKLMPDRIPVAMELRHRSWNDPAVYALLEAHRAAYVVMSGPGLVCEPVATSDLVYVRLHGPEQGAMYAGSYPDEQLRWWADKIGQWDAHGHRVVVYFNNDLGGHAVRNAGKLKEFLARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ87</accession>
    <name>A0A132PJ87_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sorbitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_19790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851843.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11130"/>
    <dbReference type="EnsemblBacteria" id="KWX22400">
        <property type="protein sequence ID" value="KWX22400"/>
        <property type="gene ID" value="AFM11_19790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1292"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="7">
        <location>
            <begin position="19"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="346" mass="35866" checksum="A2C58C75C0D6AAA3" modified="2016-06-08" version="1">MNAVAAGSPGTMRASVMTGVGTLVVEDRPVPTPGPREVLVEVAAVGVCGSDVHYYRHGRIGDFVVEDPMILGHELSGRIAAVGDGVDPGRVGQRVAVEPQHPCRRCKQCTAGRYNLCPEMKFYATPPVDGAFCRYVTIDDDMAHPVPDSMSDDAAALLEPLSVAIATMRKAGIVPGSSILIAGAGPIGVICAQAARAFGASRIVVSDLVASRRERALQFGATEVLDPTVDDVAALDPKVDAFVDASGAAPAVVSGIKAVGPAGKVVLVGMGADDVSLPVGYIQNWEITVTGVFRYTDTWPAAIHLVSSGAVDLDALVTGRYDLDHVAEALDSDTDPASLKSIVNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJF5</accession>
    <name>A0A132PJF5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851922.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11500"/>
    <dbReference type="EnsemblBacteria" id="KWX22479">
        <property type="protein sequence ID" value="KWX22479"/>
        <property type="gene ID" value="AFM11_20215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1378"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453403" evidence="1">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="139" mass="14761" checksum="0A421518BFE0A9EF" modified="2016-06-08" version="1">MIRELCVAAAITGAALATATGAAADDNMYFDEPGRYPTDVPGMSYEAHQGAPCFSWERNVFGRGPGGEPLQCRWIPNQWPPVTTGFWTHAYPLHGVQEIGSPCPGPQAAAQSPDGRPMLCLGARGWQPGVLTGNGFFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJL1</accession>
    <name>A0A132PJL1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_20075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851896.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28440"/>
    <dbReference type="EnsemblBacteria" id="KWX22454">
        <property type="protein sequence ID" value="KWX22454"/>
        <property type="gene ID" value="AFM11_20075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1351"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="229" mass="24332" checksum="6D59D5386318B607" modified="2016-06-08" version="1">MGKRQESRERIEAAIIEIGRQHLVTEGAAGLSLRAIARDLGMVSSAVYRYVASRDELLTLLVVDAYTELADAVDGAATQSDWRARIRAIAHATRDWAIDQPARWALLYGSPVPGYHAPAERTVGPGTRVVGALFAAVAAGIAAGDIATAKEAVAQPLSSDLERIRAEFAFTGDDAVVAKCFLVWAGLVGAVSLEVFGQYGADTLTDPAQMFELQIGLLIDTLACPVHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJR5</accession>
    <name>A0A132PJR5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851543.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_14950"/>
    <dbReference type="EnsemblBacteria" id="KWX22575">
        <property type="protein sequence ID" value="KWX22575"/>
        <property type="gene ID" value="AFM11_18860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1107"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="251" mass="26323" checksum="D8A9157A778F04DE" modified="2016-06-08" version="1">MGYADELFDLTDKVVLVTGGSRGLGREMAMAAARCGADVIVASRNMESCVLAAEEIAAATGRRAFAYQVHVGRWDELDGLVDAAYDRFGKVDVLVNNAGMSPLYESLGSVTEKLFDAVFNLNLKGPFRLSALIGERMVADGGGSIINVSSSGSLRPDQYMLPYAAAKAGLNTLTEGLAKAYGPSVRVNTLMAGPFLTDVSKAWDMSGEPFGHLALQRAGDPAEIVGAALFLMSDASSFTTASILRADGGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK23</accession>
    <name>A0A132PK23_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_19345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851701.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15430"/>
    <dbReference type="EnsemblBacteria" id="KWX22653">
        <property type="protein sequence ID" value="KWX22653"/>
        <property type="gene ID" value="AFM11_19345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1202"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="19"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="495" mass="52973" checksum="C8239A7A54C800B1" modified="2016-06-08" version="1">MSESPKLQHFIGGEPVAPSSGEYFESTNPATREVLYHAARGNAADIDAAVASATEAFDDPRWRDLSQTRRGHLLRRLGDLIGEHGEELARSESLDNGKLLREMRGQLTTLPEYYYYYAGLADKIHGDVIPTSDRQVLNYTVREPLGVVGAITPWNSPLTLTTSKLAPALCAGNTVVIKPSEYTSATVLKLAELVIEAGFPPGAVNVVTGFGAEAGQPLVDHPGLAKISFTGSTATGSRIASATAGRFIGSTLELGGKSPNIVFDDANVANAATGVVAGIFAAAGQTCIAGSRVFAQRAIYDELLERVSERARSIRMGNPLDDATELGPLAFEDQRDKVASYVDLGRSEGARVLTGGRATDGGLGGFFYEPTVLVDVNNQMRVVREEIFGPVAAIMPFDTEDEVVALANDTEYGLAAGVWTTNLARAHRMAGRLDAGTIWVNTYRAMSPMSPRQGFKSSGVGVEHGTETMKEYTRLKSVWINTDEGPVPDPFVMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK50</accession>
    <name>A0A132PK50_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_18845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851799.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22718">
        <property type="protein sequence ID" value="KWX22718"/>
        <property type="gene ID" value="AFM11_18845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1104"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="441" mass="47181" checksum="E78785737E97D911" modified="2016-06-08" version="1">MSHATTFKAQTPIRRYERWRFQIFAVTWIAYAGFYFTRQAFSVAKLGILEDPVLSMTLTKSTMANLDAAYLAAYAVGQFVWGQVSDRYGPRVVVLGGLAISAIATLFMGLLPALVFLLPLMIVQGLAQSTGWSGTLNNMAQFFSIGERGRVLGLWSTNYAFGGLVAAPLLGWAAYTVFGSWRAAFFTGAAIVVGVFVVVLLFQRNRPQDVGLPPIEEYHAKEEIAKLDDSPVAEAVAEPTPSWRESLAVVLRDRMVRTLGASYFLLKPARYAILLWGPVIVAERLQDGDKFQAVTIPVAFGVAGILAPILLGRVSDRVFKARRIPACVLSLAVLVAVLALFAPLTATGNAWIMTAVLGIIGLSIYGADAMISCVAAVDFGTSKHAGTASGLINGCGSTGAILGGLLPGYLSTSALFYGFAAAAFVAMLLLIPHWNRMPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKN4</accession>
    <name>A0A132PKN4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851388.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12620"/>
    <dbReference type="EnsemblBacteria" id="KWX22898">
        <property type="protein sequence ID" value="KWX22898"/>
        <property type="gene ID" value="AFM11_18595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1056"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="319" mass="33688" checksum="228C5EEE64DD007C" modified="2016-06-08" version="1">MAVSLSVGVEVTGDGLDDPGGDTTTRGIAALARRLESAGVSYWVIGAQRGEAPDAASVSLDPSVIATVAARHSTTLGLVVAAAGHRDHPYNLARRLVSVDHAAQGRVGWLALDFDHTIALNAATDTWTDARLDRHHTADVVSAVRTLWRTWPLDSVVGDRVSGVFTDVTRIRRADVRRGYDIAGPLNVPGSVQGDLPVWRQAHAGEAAEGADLLVVEYGEPIPRDRATVVRLRTGDGIDAALERLARSAVTAGAILRLAPDELPDVLDRVLPDARGRGIVSPAGAGTLRHRLRLPVPVAPDLTGHRTVFATVPNPGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKZ6</accession>
    <name>A0A132PKZ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12060"/>
    <dbReference type="EnsemblBacteria" id="KWX22924">
        <property type="protein sequence ID" value="KWX22924"/>
        <property type="gene ID" value="AFM11_17990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.954"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="350"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="486" mass="50177" checksum="E243E27121AFD8F0" modified="2016-06-08" version="1">MFVTPPNPAWAAGVCASNGKPLADGTFTLTSPFGPRGSSMHQGVDLAASEGTDIFAAMDGTVAAAGPASGFGEWIVVDSQTRTGKVSTVYGHMYADGVLVQPGAAVKEGQHIGEVGNNGQSSGPHLHFEYWEGGRLTQGQAVDPSFVLDGPSLPADATAGQQVSAAADCKTGVRKPGVVPPEFVPWLLRAGALCPGITAPLLAAQLEAENGFRHGANAPVSPTGAKGPAQFMPATWAVWGKDADNSGPPPDVNSIADAVMAQGALMCENYKLCADGIKSGSITGDPVALALAAYNAGFGAVQRNRGMPSGGDYTIQTQPYVYTIMQRARAFEASPSFGGAPQIQVPAGTTPGNRAIVEAATKFKGKKWVWGGGSFDGPTRDGFDSAGLTFFAVNRGTDGKVVLPRTTDEQWSFGKEVPLDQVQPGDLVFSGWGIGKTRLGGILGDARVRPSHVGIAIGNGQMIHADPDRGVVTADFYPGSRARRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLB0</accession>
    <name>A0A132PLB0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850623.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19885"/>
    <dbReference type="EnsemblBacteria" id="KWX22967">
        <property type="protein sequence ID" value="KWX22967"/>
        <property type="gene ID" value="AFM11_16435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.635"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="363" mass="39212" checksum="ED7C1A9F16608358" modified="2016-06-08" version="1">MTGPLHGLRVVELAGIGPGPHAAMILGDLGADVVRIERPNRGGGVPAGDRDSMLRNRRSVAADLKSDEGRELVLRLISKADVLIEGYRPGVTERLGLGPDDCAKVNDKLIYARMTGWGQEGPRALQAGHDINYISLNGLLHAVGRKGERPVPPLNLAGDFGGGSMFLLVGILAALFERQTSGKGQVIDAAMVDGSSVLMQMMWGFRANGMWSDERGTNMLDTGAPYYDTYETADGKYMAVGAIEPQFYAELLKGLGLDSADLPGQNDIARWPELREAFTKAFAAHNRDHWAEVFNGTDACATPVLSFAEVLTEPHIAERDTFYDDAGNLQPMPAPRFSRSTLARPTPPGERGADTEAVLRDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLC4</accession>
    <name>A0A132PLC4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_16930</name>
        <name evidence="5" type="ORF">AWC31_01500</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01500"/>
    <dbReference type="EnsemblBacteria" id="KWX23151">
        <property type="protein sequence ID" value="KWX23151"/>
        <property type="gene ID" value="AFM11_16930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13401">
        <property type="protein sequence ID" value="ORX13401"/>
        <property type="gene ID" value="AWC31_01500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.739"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX13401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="354" mass="37844" checksum="25B7812E064932E6" modified="2016-06-08" version="1">MRAARMYGYHQPLRLEEVDVPHIGPEEILVKVGGAGMCRTDYQLIDGYFDRGLAMDYPITPGHEVAGWVDGVGSAVPASAGLSEGDQVVVYGSWGDGACRQCHNGNEQLCAHGTWAGFGRHGGYQEYLPVNYRYLIKMPGRGGLSPENLAPLTDAGLTPYRGLKKLRDAGHLRAGGTIGVSGIGGLGSYGVQYAKLLSGGADVVAFARSDEKLEIAKTNGADHVINVRGKDVDAVREELETLTGRTELDAVIECAGSEDALRLAFALLAAEGAVASVGLIGNRVDIPLFPLVAREYTYFGSFWGNFNDLTEVLALAEAGQIKDTVTRVRWEDVNDTLDAIGRGEVLGRAVIVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLG1</accession>
    <name>A0A132PLG1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850735.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01305"/>
    <dbReference type="EnsemblBacteria" id="KWX23017">
        <property type="protein sequence ID" value="KWX23017"/>
        <property type="gene ID" value="AFM11_16735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.700"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="152" mass="15801" checksum="A0815D4DCE60C24F" modified="2016-06-08" version="1">MGGGLAGVAARQHPDLTSTKSRVVETDDADPVLAGIVLTLLAVDGIISAVVGALLLPSYIGGIPFPISAVVSGVVNAALVWAAMQWSDSLLRGGLPLWTWLAAVVAMTFGGPGNDYIFAGSGIFAYGALIFIAVGALPAAWLLRRRYRRQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLJ6</accession>
    <name>A0A132PLJ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_15440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850229.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16335"/>
    <dbReference type="EnsemblBacteria" id="KWX23216">
        <property type="protein sequence ID" value="KWX23216"/>
        <property type="gene ID" value="AFM11_15440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7203"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="108"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="330" mass="35522" checksum="D856D29698DD5F15" modified="2016-06-08" version="1">MSTQIDLVPVKPTTAIVGEADTETARRRDPGVWLRMLGNDRVAAAAATVLALVFLVAIFGPMLVGDLATDIDLDNSNQAPFTLAHGWANILGTDPLGRSMLARLIVASRTTLSVAVPAVVISAVIGSMIGMWAGFHRGWRETVAMRVADVIMSFPSLLLAVVVLYVFSPSAANIILVLAITRIPVYLRTARAESAELQSRVFVDAARTFGAGASSIIMRHVVPIVLPTLLTVATLDFCYVMLAESSLSFLGIGIQPPDISWGLMVSQGRTYLHTAWWLSFFPGLAIVITTVSATILAAWARIATDPGQRWRLTVPQKRLSRFTGAAKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLQ1</accession>
    <name>A0A132PLQ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_15750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850342.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16015"/>
    <dbReference type="EnsemblBacteria" id="KWX23269">
        <property type="protein sequence ID" value="KWX23269"/>
        <property type="gene ID" value="AFM11_15750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7273"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="71"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="219" mass="22982" checksum="266CFC39FCAEA4F5" modified="2016-06-08" version="1">MSVSARWTAAVLVVLVALGAAFWLELRDDPSATPGTGPATARDHRDADTPEALEGPRARADLPPCPGPGTGPGPEALRGITLECAGDGKPVDVAAALAGRAVVLNLWAYWCGPCADELPAMAEYQRRNPDVLVLTVHQDENETAALIRLAELGVRLPTLQDGRRLVAAALKVPNVMPATVALRPDGSVAEILPRSFVSADEIAAAVDDKIRPSRQEHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLU8</accession>
    <name>A0A132PLU8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">AFM11_16075</name>
        <name evidence="6" type="ORF">AWC31_16650</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850454.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16650"/>
    <dbReference type="EnsemblBacteria" id="KWX23325">
        <property type="protein sequence ID" value="KWX23325"/>
        <property type="gene ID" value="AFM11_16075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18028">
        <property type="protein sequence ID" value="ORX18028"/>
        <property type="gene ID" value="AWC31_16650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7340"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX18028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="54" mass="6503" checksum="351EE1D13068940E" modified="2016-06-08" version="1">MARTDIRPIVKLRSTAGTGYTYVTRKNRRNDPDRIVLKKYDPVIRKHVDFREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLX4</accession>
    <name>A0A132PLX4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850391.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16480"/>
    <dbReference type="EnsemblBacteria" id="KWX23293">
        <property type="protein sequence ID" value="KWX23293"/>
        <property type="gene ID" value="AFM11_15905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7306"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rossmann-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="153"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="315" mass="32773" checksum="A4D16E846374FCBD" modified="2016-06-08" version="1">MEQSPARGWSPPDGLRPARLSVGIVSAGRVGTALGYALERAEHVVVACSAISEPSRLRAQRRLPDTAILPVHDVAQRSELLLLTVPDAELAGLVSGLATTGAVRPGTIVAHTSGANGVAILAPLAEQGCIPLAIHPAMTFTGSDEDIARLPDTCFGITAADEVGYAIGQSLVLEIGGEPFRVREDARTQYHAALAHASNHLVTLVLDSVDALRASLRGQELLGQELVGDEPGGIAERVVAPLARAALENALQRGQAALTGPVARGDAAAVAAHLNALQELDPELAQSYRANSLRTAQRAHSPKEIFAVLAEASEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM10</accession>
    <name>A0A132PM10_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosyl-3-phosphoglycerate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16945</name>
        <name evidence="3" type="ORF">AWC31_01515</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850810.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01515"/>
    <dbReference type="EnsemblBacteria" id="KWX23052">
        <property type="protein sequence ID" value="KWX23052"/>
        <property type="gene ID" value="AFM11_16945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13235">
        <property type="protein sequence ID" value="ORX13235"/>
        <property type="gene ID" value="AWC31_01515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.742"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="316" mass="33677" checksum="83D2617C1CE6DD43" modified="2016-06-08" version="1">MTAMPELAITDGVAGHRWLSDHSWNRPTWTVAELEAAKAGRTVSVVLPALNEEETVGSVVETITPLLGGLVDELIVLDSGSTDDTEIRALAAGARVISREVALPEVAPQPGKGEVLWRSLAATTGDVIAFIDSDLINPDPMFVPKLLGPLLTTDGVHLVKGFYRRPLNVSGREDANGGGRVTELVARPLLASLRPELTCVLQPLGGEYAGTRELLTAVPFAPGYGVEIGLLIDTYDRLGLDAIAQVNLGVRAHRNRPLTELASMSRQVIATLMSRCGITDSGMGLTQFFADGDGFTPRVSSVSLADRPPMVTLRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM82</accession>
    <name>A0A132PM82_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EspB_PE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849765.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23446">
        <property type="protein sequence ID" value="KWX23446"/>
        <property type="gene ID" value="AFM11_14255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6958"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041275">
        <property type="entry name" value="EspB_PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18625">
        <property type="entry name" value="EspB_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EspB_PE" evidence="2">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="520" mass="51456" checksum="617A4028F46E9986" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMM1</accession>
    <name>A0A132PMM1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850012.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17895"/>
    <dbReference type="EnsemblBacteria" id="KWX23565">
        <property type="protein sequence ID" value="KWX23565"/>
        <property type="gene ID" value="AFM11_15010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7113"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="217" mass="23856" checksum="1180460A27BB908C" modified="2016-06-08" version="1">MRISELAEQSGVTVATIKYYVREGLLPPGSKMGERRAEYGDRHVARLRLLRVLREVGDIPVSDLKQVVDAIDNESLSTHEMNGAAYDALVRTPGAVNAEMRALATQVVQEAGWTRVRPESPAIDHLAGLLGVVLDLSAMFDMNHAATYLGLIDALAAYEVGRLNTAERIEDRDAVVQQMVIGQVVFGQLLLSLRRIAHEHHSALRFFDEPPAGTHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMP6</accession>
    <name>A0A132PMP6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850100.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18035"/>
    <dbReference type="EnsemblBacteria" id="KWX23608">
        <property type="protein sequence ID" value="KWX23608"/>
        <property type="gene ID" value="AFM11_14865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7084"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="432" mass="44791" checksum="702487EFA7BC4C10" modified="2016-06-08" version="1">MVDARAPIALWRSLRGMTEFRRLLELRAVSQFGDGLFQAALAGAILFNPEREAEPWAIAAAFAVLFLPYSLLGPFAGALLDRWDRRLVMIGANLGRLLLVLLVGVLLAFGVSDVPILCGALIVNGFTRFVSSGLSAALPDVVPPGQVVTMNAVASATGALAAFLGANFMLLPRWVFGAGDAGASVIIFIVLVPVALALWLSVRFGPHVLGPHESKRAIHGSAAYAVATGWLHGARTVLAVRTVAGTLAGLAAHRMAFGINTLLVLVIVRHADTPAEVAGLGLGTAVVFVAATGTGSFLATLAAPAVIARLGRYATANWALAFAAVVQMVAIGLDLPVMLVCGFLLGAAGQLVKLCADSAMQLDVDDALRGHVFTVQDALFWMSFIAAIAGSAVFIPSDGQTPGLVATGSVIYLAGLVVHAMVASPRRIQPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMR3</accession>
    <name>A0A132PMR3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12525</name>
        <name evidence="3" type="ORF">AWC31_02785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848940.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02785"/>
    <dbReference type="EnsemblBacteria" id="KWX23626">
        <property type="protein sequence ID" value="KWX23626"/>
        <property type="gene ID" value="AFM11_12525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11297">
        <property type="protein sequence ID" value="ORX11297"/>
        <property type="gene ID" value="AWC31_02785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6595"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="142" mass="15187" checksum="089F608D0DABA0D4" modified="2016-06-08" version="1">MQLLKRVWLPLVAVAVIGVAGFAVDRVRGVFASDPPLTTPVEFANDPEPFDPKVLTYEIFGPEGAAVDVNYVDLEGEPQRVDAAVLPWSITLQTTEPSAAANIVAQGKTDFLGCRVIVDGEVKDERSATGTNVQTFCIVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMU2</accession>
    <name>A0A132PMU2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_14710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849916.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18190"/>
    <dbReference type="EnsemblBacteria" id="KWX23517">
        <property type="protein sequence ID" value="KWX23517"/>
        <property type="gene ID" value="AFM11_14710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7051"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="504" mass="52510" checksum="BD3221B7DA7F3638" modified="2016-06-08" version="1">MSLTAPRYRMPTGVDELTPIRTVSPIPEHLRVSVSSGRTQVDITLPANARVADILPYLVRLIADHERTGEEPASIDDERTSRNTLTRGSQELPADRTLREAGVRHGDVLTLCAEPTLLPPIRYDDVVDAAAQLNRASYASWGPTSAAVMAIVALYACVGILGWMSLDMRFDPARPVIVGLDLAGSLALVAAATVAQRMYSYGRVAAVLGWAAILLAGAASLAIFAGLPGWGVVATCGAVIVLSYGAYRLIGAGGGGYLAGALYAAVMGVVVAVRTGFGVTDDRLGVAVCLVTLLLCWAVPRVTAGWDRFDLRTGSTAAPVEALDDPFGTVADRSLPDRRQLVETVPTADEIRERGRAAVSVRAALYVGCGAALVSGMALLLTPWGQPRWPDLAFGALCAVVFGLRVRLCRSAAEQSGVLLTAAVAIIITCVAATAGPPEFAATGLAGLGLIVAGGAATAVFMGPARSRRRDRALDYLNYLAVAALVPVALAVLGLYTQLRAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMX7</accession>
    <name>A0A132PMX7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849652.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23392">
        <property type="protein sequence ID" value="KWX23392"/>
        <property type="gene ID" value="AFM11_13935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6890"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="289" mass="30712" checksum="209BD1002988DBB4" modified="2016-06-08" version="1">MSTTQVLRSRFPRAFSRTADVAGAPARFLDSMGHVAWFVVQAIVHVPHAFRHYRREALRLVAEIGMGTGAMAVIGGTVAIIGFVTLSAGSLIAIQGFASLGNIGVEAFTGFFAALANIRVVAPVVTGQALAATVGAGATAELGAMRISEEIDALEVMGIKSISYLVSTRIMAGAIVIIPLYAMAILLSFMSAQLVTTIFYSQSVGTYEHYFHTFLRVDDVMWSFLEVIIMSIVVMLNHCYFGYFASGGAVGVGEAVGRSMRTSLIAIVLVVLLASLALYGTDPNFNLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNL6</accession>
    <name>A0A132PNL6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_11215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848107.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30680"/>
    <dbReference type="EnsemblBacteria" id="KWX23939">
        <property type="protein sequence ID" value="KWX23939"/>
        <property type="gene ID" value="AFM11_11215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6320"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="26"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="303" mass="32591" checksum="FA0C50BEA6161DEC" modified="2016-06-08" version="1">MTTTLEVLRTGPLALVEDLGRPGLAHMGVSRSGAADRRSHTLANRLVANPGERATIEVTFGGFSARVRGGDVAIAVTGADTDPAVNGVPFGINSIHHVHDGQVISLGAPHSGLRSYLAVRGGIAVEPILGSRSYDVMSAIGPAPLRPGDVLPVGEHTDEFPELDQAPVAAISDDIVELRVVPGPRDDWFVDPDILTRTNWLVTNRSDRVGMRLVGMPMDYRWPDRQLPSEGATRGAIQVPPNGFPVILGPDHPVTGGYPVIGVVIDEDIDKLGQVRPGQTVRLHWAYPRQPFEVSQDTFAERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNN1</accession>
    <name>A0A132PNN1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849021.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02950"/>
    <dbReference type="EnsemblBacteria" id="KWX23652">
        <property type="protein sequence ID" value="KWX23652"/>
        <property type="gene ID" value="AFM11_12670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6624"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="22"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="372" mass="39227" checksum="535920B9175985F3" modified="2016-06-08" version="1">MKPAICEQFGIDFPLFAFSHCRDVVAAVTNAGGFGVLGATAYTPEQLDRELSWIDEQVGGKPYGADIIVPAKFEGKGENLSRGELVDRIPAEYREFVAQLLVDHGIAPEAKQRTGGSMLSGDTGAELLQVAMSHPIKLIANALGVPPDYMIEAGREHGVPVAALVGAREHAVKQVQAGVDLIIAQGTEAGGHCGEVTTMVLIPEVIEAIEGAVPVLAAGGIVTGRQMAAAVALGAAGAWTGSVWLTTEEAETAPHTVQKMLAATSRDTVRSAGRTGKPARQLVSEWTDAWLPNQGGRQPLPLPLQNMLAEPVIRRVDVLAAQGHPGAQALATYFVGQGVGLMNKVKPAREVVREFIEDYLAATERLSNSLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNU4</accession>
    <name>A0A132PNU4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849204.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03350"/>
    <dbReference type="EnsemblBacteria" id="KWX23712">
        <property type="protein sequence ID" value="KWX23712"/>
        <property type="gene ID" value="AFM11_13065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6706"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="253" mass="26630" checksum="A6722CC7742C7584" modified="2016-06-08" version="1">MTTPQSERRVAVVTGASAGIGAATAKTLASLGFHVVCAARRADRVQALADEIGGTAVVADVTDPDSVTALAAGLDRVDVLVNNAGGAKGLEPVADADLDHWRWMWEANVLGTLLVTRALLPKLIDSGDGLIVTITSIAAVEIYDNGGGYTSAKHAQGVLHRTLRSELLGKPVRLTEVAPGMVKTDFSLNRFDGDEERAAKVYEGVTPLVAEDIAEVVGFVASRPSHVDLDLIVVRPRDQVTGASGSRFNRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNW6</accession>
    <name>A0A132PNW6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848288.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23993">
        <property type="protein sequence ID" value="KWX23993"/>
        <property type="gene ID" value="AFM11_11530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6382"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="289" mass="30524" checksum="647854CA02BC46EE" modified="2016-06-08" version="1">MKIVLGKDDLAATAVAAAGADAERLGIRPVHKASRGFVSGTSADICELAIVTLLQAVAYDKPVALLPITMLGRHQHQTLVTMGDLGIADLPGRRVGVRSWSQTTGVWLRGFLSEQYGVDLKTIEWQTYEGAHVDEAADPSWVARADDGAKLQVDFLEGRLDYGIMGNERPDDDRIRTAIPDAAEVAAKWAADHGFAPVNHVVGVNVAAAKADPAAVLAVYDALARAVSGLPANGSVNLNPVGFNGLRGPITAAARYAYEQQVLPRPVEFDEIVDRTCAALGVPASRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNZ8</accession>
    <name>A0A132PNZ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10055"/>
    <dbReference type="EnsemblBacteria" id="KWX24061">
        <property type="protein sequence ID" value="KWX24061"/>
        <property type="gene ID" value="AFM11_11915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6462"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="47"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="176" mass="19699" checksum="66264010AE7C9E8C" modified="2016-06-08" version="1">MHPLRLTPLPFEQWDDNTRAALASLIPAERANPEGAGNVLSTLVRNPDLTRAYLPFNAYLLRGSRLSPRIREVALLRIVLRTDCDYLWTHHLPIARQAGLTDDDIDGIRSGHCADAHDDVIVCAVDDLVAFHTITQSTWDRLAEFLDENQRMDLVFLIGGYQLLALAVNAFGVRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPG4</accession>
    <name>A0A132PPG4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilotriacetate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847045.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05890"/>
    <dbReference type="EnsemblBacteria" id="KWX24195">
        <property type="protein sequence ID" value="KWX24195"/>
        <property type="gene ID" value="AFM11_09335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5904"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="143"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="434" mass="47518" checksum="B279032FCE936C98" modified="2016-06-08" version="1">MPRELHLLAFGNTRSAGPWRHPDVDNSTAGVRRRLFEHARTAEAGTFDALFFADGLNYGPPATWAYKTTEDFEPLTTTAALSSVTESIGLVVTGSATLAHPYHLARQLLSLDHLSGGRAGWNLVTSFARAAADNFSADGVRAHDERYLIAGEALEVVRKLWDGWGEDTIVEDRAAGIFNDVNSIRPADHHGRYFDVAGPIGAARSPQGQPVLFQAGSSDTGRTFAATHAEVIFTSHGNRGRAEEFYRQIHQESRRLGRSKPPLITPSLRYVVGSTDEEARRAEREEYEYFSPEYQAGWLLEVDVDVTGADLDGPVPASAFPDHTETHQTALAGYRHLASDGNPSVREFLYRTVNGWGAAVVGTPERIADEIEEWFTAGAADGFVLRDTGLPGQSALFVEQVVPVLRKRGLFRHEYSGTTLRSHLGLDVPQGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPJ9</accession>
    <name>A0A132PPJ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_09500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847136.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05725"/>
    <dbReference type="EnsemblBacteria" id="KWX24223">
        <property type="protein sequence ID" value="KWX24223"/>
        <property type="gene ID" value="AFM11_09500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5937"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="270" mass="29473" checksum="DA613FE34BE3C403" modified="2016-06-08" version="1">MTPRPPEGDWLGTPYLTFDRQGPFGVVTLDRPEARNAMTPAMYFGIRYAVTHVESDPDLAGLLITGTGDVFAPGGDLGGGDGVDDWMSFGAALSMDVTPFETLRQSVKPVVSAVNGLCQGGGLQIAMCSDMAVVSDRATFRVPELYRGIADTYYSQMLARLIGPVRTRDLMFTGRTLSADEAVDWGMVARVVPHDQLLDTAREVLAKCCRTAPRARGVVKSSLDNYLGLFDRIGMKASYSGDEAAEGFRAFKQRRSPEWVHPELRIEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPP1</accession>
    <name>A0A132PPP1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mandelate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847397.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05235"/>
    <dbReference type="EnsemblBacteria" id="KWX24308">
        <property type="protein sequence ID" value="KWX24308"/>
        <property type="gene ID" value="AFM11_09990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6034"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="2">
        <location>
            <begin position="140"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="378" mass="40321" checksum="C13647926A5CF3CC" modified="2016-06-08" version="1">MKITGIQTCGLRGATPEGGWSNELRPDDVVHTLVAVHTDSGQVGIGSAFTTEGLVAAAVDVLAPQLIGQSALEAERLTETLHQTAFWMGRGGSLTHATSAIDIALWDLAGQALGQPVGRLLGGRYRDRVRPYASVLMDEAPVMTENLSQLAEQGFTAFKIGWWKFGRVDSETDERTVAAAREAVGDHMLAVDAGGSEAFFPGGLSWAKRTADMLADYGVAWFEEALAPDDVDGFVELRRHSKVPISGGEVLTRRQTFLPFLDAGAFDIVQPDTTKGGGLSESRRIGWAAQDRGVRLIPHGWNTAIGLAADLHLASALAATDFVEYKTGSAYIDELVSGGWDLDNEGMLAVPDGPGLGVTLDRAALERYGTRPTFADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPV8</accession>
    <name>A0A132PPV8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_10400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847606.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18835"/>
    <dbReference type="EnsemblBacteria" id="KWX24371">
        <property type="protein sequence ID" value="KWX24371"/>
        <property type="gene ID" value="AFM11_10400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6119"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="28238" checksum="B1BAE4B8AD56685E" modified="2016-06-08" version="1">MFSPTGRRALRIWTAVVLVFLYTPLLLVLVNAFNASRTFAFPPTGFTWAWWADAARSTGMWKALANSVVVGLGATAIALVLGTMIAFAVQRYRFFGRSAVSFLVVLPITLPGIVTGIALNATFTSALAMTLGLATVIIGHATFCIVIVFNNIAARLRQMGTSLQDASADLGASSWQTFRFVTLPMARGALVAGAILAFALSFDEIVVTTFTAGPTVQTLPIWIFSNLFRPNQAPVINVVAAALTVLAIIPVWLAGRFGGDPGTRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ62</accession>
    <name>A0A132PQ62_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_09340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847905.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24471">
        <property type="protein sequence ID" value="KWX24471"/>
        <property type="gene ID" value="AFM11_09340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5905"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026954">
        <property type="entry name" value="PknH-like_Extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038232">
        <property type="entry name" value="PknH-like_Extracell_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14032">
        <property type="entry name" value="PknH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453535" evidence="4">
        <location>
            <begin position="31"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PknH_C" evidence="5">
        <location>
            <begin position="42"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="230" mass="24610" checksum="1E2B121AE5A4562F" modified="2016-06-08" version="1">MTRLCATGVAVILSGLLSGCVNTVTGSAMRDPDAPPFETTLTESDLDQLLVPVEQLNDIVGSFDLEVTLELDELNDNSEAVSDPECLAAAFGAQELVYGDTGWTALRDQIVREPGEDNAHWIEQAVVLYPSSDEAREFFDTSQATWDNCVGSIVTYNQDNQPLEWAVSEVTAEETTISQMSTPEGAPSGGCHHALSVASNVVVETWACGDDIVDQASEIAGEIVANIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR31</accession>
    <name>A0A132PR31_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846753.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13330"/>
    <dbReference type="EnsemblBacteria" id="KWX24790">
        <property type="protein sequence ID" value="KWX24790"/>
        <property type="gene ID" value="AFM11_09040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5658"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030310">
        <property type="entry name" value="FadD17/FadD6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="PTHR43107:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="59"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="410"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="508" mass="54103" checksum="957F47DF332508E3" modified="2016-06-08" version="1">MTGPTVTELLAPLADVTDRGIHEGDSFVSWADHISAGAQVAAALRARLNSRTRGGQQAGARPPHVGVLLGNTPFFSSLLVAAGLTGLVPVGLNPTRRGDALIRDIERADCQLVLADDAGLVPPGVDYIDVESEGWAAELASHAGTPVTFADPSPDDLFMLIFTSGTSGEPKAVRVTHDKVAFPGRMLADRFGLGPADTAYLSMPLFHSNAIMAGWAVAVAAGASIALRRKFSASGFIDDVRRYGATYANYVGKPLSYILATEPRPDDADNPLKILYGNEGAPRDLDRFAKRFGVVVVDGFGSTEGGVAIARAPGTPEGSLGPLTDEVAVVDVETGEPCPPGVVGELVNPTGRGWFRGYYNDPDAEAQRMAGGVYHTGDLAYRDEDGYVYFAGRLGDWMRVDGENLGTAPIERILMRYPDVVEAAVYPIPDPAVGDRVMAALVLAAGAEFDPDKFRQFLHEQPDLGPKQWPSYVRVGTALPRTETFKVIKRQLSAEGTECADPVWAIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRA2</accession>
    <name>A0A132PRA2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl-CoA:diacylglycerol acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.122</ecNumber>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_08775</name>
        <name evidence="10" type="ORF">AWC31_13595</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:23472"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:18195"/>
            <dbReference type="ChEBI" id="CHEBI:18234"/>
            <dbReference type="EC" id="2.3.1.122"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mycobacterial A85 antigen family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="4"/>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846608.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13595"/>
    <dbReference type="EnsemblBacteria" id="KWX24856">
        <property type="protein sequence ID" value="KWX24856"/>
        <property type="gene ID" value="AFM11_08775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18569">
        <property type="protein sequence ID" value="ORX18569"/>
        <property type="gene ID" value="AWC31_13595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5603"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050348">
        <property type="term" value="F:trehalose O-mycolyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453220" description="Acyl-CoA:diacylglycerol acyltransferase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX18569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="272" mass="27081" checksum="0092FD57056C6100" modified="2016-06-08" version="1">MARMPTLTRRAVLRLGVGAAAGAAGALALGSVPAAAAPTYVTGSFVSAARGGVDTNWAIARPPGQTGALRPVIALHGKGQDAAGVMAGGVEQGLAEAVAAGLPPFAVVAVDGGGSYWHKRASGEDSGAMVLNELIPMLGEQGLDTSRVAFLGWSMGGYGALLLGSRLGPSRTAAICAVSPALWTSSGAAAPGAFDSAEDYAANSVWGAPALGSIPIRIDCGNSDPFYSATKQFVAQLPNPPAGGFSPGGHDGAFWSSQLPAELTWMAPLLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRA5</accession>
    <name>A0A132PRA5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intersectin-EH binding protein Ibp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08960</name>
        <name evidence="4" type="ORF">AWC31_13410</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24860">
        <property type="protein sequence ID" value="KWX24860"/>
        <property type="gene ID" value="AFM11_08960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18567">
        <property type="protein sequence ID" value="ORX18567"/>
        <property type="gene ID" value="AWC31_13410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5641"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453521" evidence="2">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="122" mass="11632" checksum="3EC8CCC6284FCDE8" modified="2016-06-08" version="1">MRRLILAGGFVVAAAAAPAITVFAVPMSSAPAVACPSGEEEDLYTGVCVPHTVPNSGGAFSPIPGNPSLPAVNLPGGGGAIPCTGANSGQCIGLAEEAQAAGPQAVPESTVGSSPTVHGSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRP0</accession>
    <name>A0A132PRP0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845135.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11745"/>
    <dbReference type="EnsemblBacteria" id="KWX24965">
        <property type="protein sequence ID" value="KWX24965"/>
        <property type="gene ID" value="AFM11_05885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4368"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="53"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="212" mass="22536" checksum="923CC16D0F2BB565" modified="2016-06-08" version="1">MTSPGSPFDFDALYRGESPAEGVPPITTPPWDTKAPKENVVAWAEAGLVHGHVLDIGCGLGDNAIYLAQQGYEVTALDISPTALITAERRAADAGVKITFAVSDATRLDGYDDAFDTVIDSGMYHCLDDDGKRGYAAAVHRASRPGATLLLGAFSDANLQQPDWGAPTVSEETLRTTLGDAGWDITSLTTETTTLPHNGADASFWLLQAQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRS1</accession>
    <name>A0A132PRS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_06320</name>
        <name evidence="6" type="ORF">AWC31_29355</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845264.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29355"/>
    <dbReference type="EnsemblBacteria" id="KWX25041">
        <property type="protein sequence ID" value="KWX25041"/>
        <property type="gene ID" value="AFM11_06320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13961">
        <property type="protein sequence ID" value="ORX13961"/>
        <property type="gene ID" value="AWC31_29355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4458"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX13961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="267" mass="28211" checksum="AEABA371DD8A003D" modified="2016-06-08" version="1">MSPGLSAHARRAAIATRIHTDREVDFTSLADEFGVSAMTIRRDIERLEDQGIARRVLGGAIAFGGKSTEPSFASRAAESADEKLHIARAVADLLTPQETVILDSGSTVLAVARALKGRDLGLTVITPSVLVAVELAEEPGTTVLLTGGKVRPGELSLIGAEAEDFYLRYNCDTYVMGIAGVDGRRGASEYHREEGNVKQAAMRSADRVIVAADATKLGRVQLINVAPVSDISVLVTDGSPTHPTVEALREAGVEVLCVNAVRSTPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRW0</accession>
    <name>A0A132PRW0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_06570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845344.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29105"/>
    <dbReference type="EnsemblBacteria" id="KWX25081">
        <property type="protein sequence ID" value="KWX25081"/>
        <property type="gene ID" value="AFM11_06570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4509"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="116" mass="11913" checksum="595D958F4EDCA11F" modified="2016-06-08" version="1">MAVPKTYVALAAIQAGDAAACAFKAPPIVKAFDDLGVPPRIRWIFPVIKSASAVGLLAAGRYPALGRLTTALLTVYFVLAVGAHIRAHDKPVNAIPAAGFVATYAVLTAKGTGRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRX2</accession>
    <name>A0A132PRX2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845352.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29075"/>
    <dbReference type="EnsemblBacteria" id="KWX25086">
        <property type="protein sequence ID" value="KWX25086"/>
        <property type="gene ID" value="AFM11_06600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4515"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="421" mass="45074" checksum="A99F38B32A3AFE05" modified="2016-06-08" version="1">MTDHSRGRGVALPAGVEGAADRSFACTVRGFAQLFPGRRFGGGALAIYLDGEPVLDVWTGYSDRAGTLRWTADTGAMVFSATKGMASTVIHRLVDRGLIEYDAPVCAYWPEFAANGKADITVREVMRHRAGLSQLNGVSKADLLDHRTMEARIAATPVNRLLYGKSAYHALTYGWLMSGLARAVTGQDMRALFRTELAEPLRTDGLHLGRPPVGAPTRAAQILAPQRTWPNQVFDFIAPRVAALEFSGFFGSTYFPGVMSLVQGDTPFLDAEIPAANGVATARGLAKMYGAIANRGRFDGAEYLSQRTVAGLTGRPSLRPDRNLVVPLAFHLGYHSVPFSVMPGFGHVGLGGSVGWADPASGLAIGYVHNRLLTPMVLDMAAFVGLNALIRNDVARARKRGYLPVPELGAPPYEVPRPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSF0</accession>
    <name>A0A132PSF0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_07180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845914.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17535"/>
    <dbReference type="EnsemblBacteria" id="KWX25269">
        <property type="protein sequence ID" value="KWX25269"/>
        <property type="gene ID" value="AFM11_07180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4636"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="4">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar-bind" evidence="3">
        <location>
            <begin position="120"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="340" mass="35881" checksum="386BA59E1CC7BB8D" modified="2016-06-08" version="1">MPRSAQPTSQANVDGSPPDAESGHFPASLLYAAAKLYYNEEATQAEVAAQLGTSRATVSRLLAEAKRRGIVRIEVVPPDGLGAGDIAAQLTRALALNTVFLSHPLPHPGPGRTHVDVMGGALAPAVGRALSAAGLLPGDVLLVSSGRTVYEVAQYELVDLPGVLVAPTVGGNDQPEEWYQTNEITRLVANRVNGRPNYLFAPALPGPDLYPSLINDPSIQRVLNLWPRARCALMGVGAPPLMRSDIPRFVPTESSSLRSAVGDVCSRFFDRAGEAVEFDGSDRLIAVELEALRHVPVTIAVAIGKDKVESIIAGARGGYFNQLVTDPATAAAILETTESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PST0</accession>
    <name>A0A132PST0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03850</name>
        <name evidence="4" type="ORF">AWC31_21315</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844230.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21315"/>
    <dbReference type="EnsemblBacteria" id="KWX25408">
        <property type="protein sequence ID" value="KWX25408"/>
        <property type="gene ID" value="AFM11_03850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16569">
        <property type="protein sequence ID" value="ORX16569"/>
        <property type="gene ID" value="AWC31_21315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2647"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036435">
        <property type="entry name" value="Leukocidin/porin_MspA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015286">
        <property type="entry name" value="Porin_fam_mycobact-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09203">
        <property type="entry name" value="MspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56959">
        <property type="entry name" value="SSF56959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453559" evidence="2">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX16569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="211" mass="22127" checksum="7CFB7FDE37C19A60" modified="2016-06-08" version="1">MKAISRVLIALVAAIAALFTSTGTSHAGLDNELSLVDGQDRTLTIQQWDTFLNGVFPLDRNRLTREWFHSGRAKYIVAGPGADEFEGTLELGYQIGFPWSLGVGINFSYTTPNILIDDGNITQPPFGLESVITPNLFPGVSISADLGNGPGIQEVATFSVDVSGAAGGVAVSNAHGTVTGAAGGVLLRPFARLIASTGDSVTTYGEPWNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT22</accession>
    <name>A0A132PT22_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844405.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20975"/>
    <dbReference type="EnsemblBacteria" id="KWX25460">
        <property type="protein sequence ID" value="KWX25460"/>
        <property type="gene ID" value="AFM11_04180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2713"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="2">
        <location>
            <begin position="107"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="370" mass="40203" checksum="582CB12A71F00AF7" modified="2016-06-08" version="1">MTVVLVDPRRPSLIPVDAIDLLTGDVQYTEEMPVKVPWSLPAARPAYDGDDAPVLLSSDPEHPAVKARLAAGERLIAAPEAQPGERIVDAVAMMDKLRTSGPWESEQTHDSLRRYLLEETYELFDAVRGGNADELREELGDVLLQVLFHARIAEDAPHHPFNIDDVADALVRKLGNRVPAVLAGESISLDEQLAQWEERKAQERSVKSRTSSMDDVPTGQPALALAQKVIARVTQAGLPADLVPASLTSVTVSGDTDAENELRTAVLEFMDTVRLVESDVAAGRRGEDVPEELDVTPLGTITEDEWRTYWPTGDFAAAEPEPAVDETADVDEESAPDETPAEAPTPDEQSEPDEAQTESEGPAQPDRADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT35</accession>
    <name>A0A132PT35_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metal ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_04265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844445.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20890"/>
    <dbReference type="EnsemblBacteria" id="KWX25473">
        <property type="protein sequence ID" value="KWX25473"/>
        <property type="gene ID" value="AFM11_04265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2731"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="641" mass="65979" checksum="706D58468E3D3C38" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTB4</accession>
    <name>A0A132PTB4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">AFM11_04880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844662.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20265"/>
    <dbReference type="EnsemblBacteria" id="KWX25576">
        <property type="protein sequence ID" value="KWX25576"/>
        <property type="gene ID" value="AFM11_04880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2857"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="5"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="426" mass="45499" checksum="AB0094B23C8B2DAF" modified="2016-06-08" version="1">MSASLAEVDPDIAELLDKELGRQRDTLEMIASENFAPRSVLQAQGSILTNKYAEGLPGRRYYGGCEHVDVIENIARDRAKALFDAEFANVQPHSGAQANAAVLAALMAPGERLLGLDLANGGHLTHGMKLNFSGKVYESGFYGVDTATGLIDMDAVRARALEFRPKVLIAGWSAYPRTLDFAAFRSIADEVGAHLWVDMAHFAGLVAARMHPNPVPHADLVSTTVHKTLGGARSGLILGRKEFAKQLNSAMFPGTQGGPAMQVVAGKAITFKIAGTPEFADRQQRTLSGARILADRLLEADVAKSGVSVVTGGTDVHLVLVDLRNSPLDGKAAEDLLHEIGITVNRNAVPNDPRPPMVTSGVRIGTSALATRGFGDIEFTEVADIIGTALAQGAAADVAALRDRVTRLARQFPLYDGLEDWQLHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTL0</accession>
    <name>A0A132PTL0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_05060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844725.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20170"/>
    <dbReference type="EnsemblBacteria" id="KWX25604">
        <property type="protein sequence ID" value="KWX25604"/>
        <property type="gene ID" value="AFM11_05060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2893"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="402" mass="43553" checksum="445BD1C71EA77BF9" modified="2016-06-08" version="1">MLRAHDLFAPAHLQDPYPLYDRLREDAPVHQVGDSPFFVVTSFDAVTEATARMQHFSSNLTATMWHQPDSPDGSVTTFTMDGPGGHTHVLATADDPAHAAHRKLVLPRLAAKRIRDLEPFITSTTDNLLTATIGELDWMTTMADRLPMLVVARLLGLPAADVDRLVGWAYGATQLLDGLVDADQLTAAGIAATELGGYLVEQFDRAKADPGDNLLGDFALYCASEKVAADKAVFMLIQLVSAGAESTASLIGSAARELASRPALAQQLRDAPGLIPAFLEEVLRLESPFRGHYRHVSVDAELGGVALQADSHLLLLWGAANRDPAAFDDPHEFRLDRVNAKSHLAFGKGAHFCVGAALARLEARIVISRLLALRTDIQPAGPAEWLPSLLVRRLRRLPLTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTN3</accession>
    <name>A0A132PTN3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844910.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25698">
        <property type="protein sequence ID" value="KWX25698"/>
        <property type="gene ID" value="AFM11_04340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2745"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453585" evidence="1">
        <location>
            <begin position="30"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="39"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="239" mass="25027" checksum="7BF75F926531A6B1" modified="2016-06-08" version="1">MNRRAVLRVGAGFGAVTAAGVLAGPNAPASGPPTEGPWRVQILVFDGVDDLDIFAPLEVFGYATHFDPRAEVELVTGAGPGAVVLMSGTTIDVRCGWSPERADVLVVPGGGYGRPPGSPGVPSEIARGHLPRLLGAARRPGLTVTSVCVGAMLLSAAGITRNRPCTTHHRLLEQLEREGGVITKARIVDDGDLVTSGGVTSGLDLALWLIQRELSADVAIAVEEVLEYERRGTVWRKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTN6</accession>
    <name>A0A132PTN6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844625.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20360"/>
    <dbReference type="EnsemblBacteria" id="KWX25557">
        <property type="protein sequence ID" value="KWX25557"/>
        <property type="gene ID" value="AFM11_04785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2838"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="227" mass="23567" checksum="DF0C7E5F66FC4A97" modified="2016-06-08" version="1">MGEAFSWAWNKFTKHPAELLVPTLVFGLIYGALQGIIQLISSSFATTETSSYGDYGYSASYSMGTGGIVVSIIGGLVMLVVMAVIQSAYIGGMLDIANGAPVTIGSFFKPRNVGNVIIASVVSGIIVGIGILLCVIPGIIAMIMLMFTTVAVLDRNVSGIEGITTSFNIAKANFGPVALTWLVTIAIAIVGVLACLVGLLVAYPLISLITVYAFRKLTGGQVAPLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTU3</accession>
    <name>A0A132PTU3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Creatininase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Mycofactocin system creatininase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00195</name>
        <name evidence="6" type="ORF">AWC31_33305</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33305"/>
    <dbReference type="EnsemblBacteria" id="KWX25756">
        <property type="protein sequence ID" value="KWX25756"/>
        <property type="gene ID" value="AFM11_00195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11567">
        <property type="protein sequence ID" value="ORX11567"/>
        <property type="gene ID" value="AWC31_33305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.40"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023871">
        <property type="entry name" value="MftE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03964">
        <property type="entry name" value="mycofact_creat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="219" mass="22940" checksum="07236B990C833FD4" modified="2016-06-08" version="1">MSPMLVIPVGSTEQHGPHLPLDTDTRIATAVSHGVVERLVGGEWLVAPAVSYGASGEHEGFPGTVSIGTAALRLLLVEYGRSASNWASRLVFVNGHGGNVEALAAAVALLRYEGRDVGWVSCSAVDSDAHAGHTETSVLLHISPGDVWTDELTRGNTAPLAELMPRLRSGGIAAVSELGVLGDPTTATAAEGERIFAEMVNGCADRITRWQPDRNGMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU25</accession>
    <name>A0A132PU25_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_00665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842359.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25841">
        <property type="protein sequence ID" value="KWX25841"/>
        <property type="gene ID" value="AFM11_00665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.136"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="446" mass="47782" checksum="1E8BCDBB7FD30E42" modified="2016-06-08" version="1">MADGYDVVVIGAGFAGLIAARDLSTQGHRVLLLEARDRVGGRTYTGEAFGRQVEFGGTYVHWTQPNMWHELERHNIPLAVPLEPRTVYWLADGATHYGTPEEYATALDPLMGRFFADARAQFPLPFDVNVVDTSAVENETIEKRMTSLDLSAYERDLLDGAIASLVTNHKEHGVAQLLCSAATYFGSYAAFFETAGVWPIEGGTKRLVDAIVAESNAETRLSTPVASVHDDDAGVTVTTRSGEQIRALQAVIAVPLNTLGDMTITPDVPPPARAMIDQKNPIMASKIWVRAKGELEPFQALAPVGKNPINAARVEYHADGDTFIMCLCSDASAIDAADQDAVQAALRAFVPDIEVIDTASHDWATDEFSKGGWMMHRPGHFTRGAPLLRTPHGRIHFAGSDIAGIEAGAIEGAMSSGASAARNVVAALTNGRNAPPEANPPVGESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU75</accession>
    <name>A0A132PU75_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="11" type="ORF">AFM11_00825</name>
        <name evidence="12" type="ORF">AWC31_33865</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842441.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33865"/>
    <dbReference type="EnsemblBacteria" id="KWX25870">
        <property type="protein sequence ID" value="KWX25870"/>
        <property type="gene ID" value="AFM11_00825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11670">
        <property type="protein sequence ID" value="ORX11670"/>
        <property type="gene ID" value="AWC31_33865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.171"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="10">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="91"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX25870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX11670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="201" mass="23333" checksum="99CF118DD7B7C9B8" modified="2016-06-08" version="1">MARYTGPATRKSRRLGVDLVGGDQSFEKRPYPPGQHGRARIKESEYRQQLQEKQKARFSYGVMEKQFRRYYEEAVRQPGKTGDNLLRILESRLDNVVYRAGLARTRRMARQLVSHGHFLVNGVKVDIPSYRVSQYDIIDIKDKSLNTLPFEVARQTAGERPIPSWLQVVGERQRVLVHQLPERAQIDVPLTEQLIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUA4</accession>
    <name>A0A132PUA4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="ORF">AFM11_01190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842639.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34230"/>
    <dbReference type="EnsemblBacteria" id="KWX25929">
        <property type="protein sequence ID" value="KWX25929"/>
        <property type="gene ID" value="AFM11_01190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.244"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="28"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="135"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="340" mass="34482" checksum="E5095B5DF0CDECFB" modified="2016-06-08" version="1">MIILAIESSCDETGVGIADLAADGTVSLLADEVASSVDEHARFGGVVPEIASRAHLEALGPTMRRALDAAGIDKPDVVAATIGPGLAGALLVGVAAAKAYAAGWNVPFYAVNHLGGHLAADVYDHGPLPESVGLLVSGGHTHLLHVRSLGEPIVELGSTVDDAAGEAYDKVARLLGLGYPGGKVLDDLARTGDRDAIVFPRGMTGPRDEPYAFSFSGLKTAVARYVEANPDAAQADVAAGFQEAVADVLTAKAVRAATELGVSTLLIAGGVAANSRLRELAEERCAAAGLTLRIPRPRLCTDNGAMIASFAAHLIAAGAQPSPLDAASDPGLPVVKGQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUB1</accession>
    <name>A0A132PUB1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_01025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842548.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34055"/>
    <dbReference type="EnsemblBacteria" id="KWX25903">
        <property type="protein sequence ID" value="KWX25903"/>
        <property type="gene ID" value="AFM11_01025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.210"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="157" mass="17208" checksum="2C124B2858E588D2" modified="2016-06-08" version="1">MFDETDRAIIAMLCRDGRRTFTSIAAELEVSEATVRGRVAKLQEQEALHIVALCNPLTLGHQSLRLMLAVRDHTPRSVAVALTSMPLVNHVALCTGSRDVYVEATCRDLTQVRALLDDVRRIPGVATMDLYVLTELFKDYSWLGLRGGVGQGSTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUC7</accession>
    <name>A0A132PUC7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">guaB</name>
        <name evidence="16" type="ORF">AFM11_01240</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842657.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34275"/>
    <dbReference type="EnsemblBacteria" id="KWX25936">
        <property type="protein sequence ID" value="KWX25936"/>
        <property type="gene ID" value="AFM11_01240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.254"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="113"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="173"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="358"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="381"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="405"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="267"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KWX25936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="513" mass="53507" checksum="E7CB737229E671C4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUK9</accession>
    <name>A0A132PUK9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01975</name>
        <name evidence="2" type="ORF">AWC31_34755</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843016.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34755"/>
    <dbReference type="EnsemblBacteria" id="KWX26039">
        <property type="protein sequence ID" value="KWX26039"/>
        <property type="gene ID" value="AFM11_01975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11818">
        <property type="protein sequence ID" value="ORX11818"/>
        <property type="gene ID" value="AWC31_34755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.404"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="283" mass="31981" checksum="9D3DC2CBC4063517" modified="2016-06-08" version="1">MPFLGSEALAAGKLNRYHLTTRYEMLHRDVYVPRGAKLTPVDKAVAAWLWSGRRATVAGLSAAALLGSKWIDARHPAELNHSSRHETAGIVLHSDRLTDDEVRMVRGIRVTTPARTAFDLGRRPGLTEAVVRVDALLQACDLKLVDIQALVDTHRGARGLVQLRQVLDLADYGAESPQETRLRLLFTEEGMRPDETQIEVFGHWGELVGRIDMGWPDWNVGVQYDGIQHWTDPRQRTKDIDQDAEYRELGWNIIRVGNDLLRYRQRAIITRTRAALEKAGRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUL0</accession>
    <name>A0A132PUL0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Forkhead-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01745</name>
        <name evidence="2" type="ORF">AWC31_34495</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842899.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26003">
        <property type="protein sequence ID" value="KWX26003"/>
        <property type="gene ID" value="AFM11_01745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11771">
        <property type="protein sequence ID" value="ORX11771"/>
        <property type="gene ID" value="AWC31_34495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.359"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="190" mass="19862" checksum="654B79DFBC9BAC21" modified="2016-06-08" version="1">MGQNASLEGDSSVIVSLSEAAMHMYSAAIDALPFPEDKKFHKRADVVLSGMRKLRAALTEAASSNRPSPAVIVALSGVRQRYDALMAHAAAAPGSSLGQQIYVTRIHAKLSAQEVANGAGLRDGLLDELEAGATPTDDEAAKIRDTIAALGGLPGSDHGPDEVAPVVEFGQHEDNHVNDWDDALLAENAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUS5</accession>
    <name>A0A132PUS5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_02385</name>
        <name evidence="7" type="ORF">AWC31_35165</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843240.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35165"/>
    <dbReference type="EnsemblBacteria" id="KWX26109">
        <property type="protein sequence ID" value="KWX26109"/>
        <property type="gene ID" value="AFM11_02385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11885">
        <property type="protein sequence ID" value="ORX11885"/>
        <property type="gene ID" value="AWC31_35165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.489"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="50"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX26109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX11885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="252" mass="25556" checksum="15BA70455CCE706E" modified="2016-06-08" version="1">MRRGRLAGLVGSLLVLITWQLIGMTGILGPAIASPTEILAGVMSDGPGFYGIHVPVTLASASVGYFWGNLAAIGCAALVTTIPALEKLVLQAGIASACIPLIAIAPILAACFDGMVTSAIMAAVSVFFTTLVGSINGLRQADSLSKDLVRAYGGGKYLVLRKVELLSALPNILTALKVAVPAAILGAIIGEFMGQERGLGAALVVAQSSSDVVRTWGITLVSSLIAGVAFAVVNIIEKFATPWAAAVAGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUZ4</accession>
    <name>A0A132PUZ4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_02820</name>
        <name evidence="13" type="ORF">AWC31_35600</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843463.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35600"/>
    <dbReference type="EnsemblBacteria" id="KWX26178">
        <property type="protein sequence ID" value="KWX26178"/>
        <property type="gene ID" value="AFM11_02820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11959">
        <property type="protein sequence ID" value="ORX11959"/>
        <property type="gene ID" value="AWC31_35600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.581"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="322"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX26178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX11959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="442" mass="47655" checksum="5C05726910480327" modified="2016-06-08" version="1">MRIAVLGTGYLGATHAACMASLGHDVLGVDVDEAKLAKLRSGEMPFYEPGLDELTQDMLASGRLQFTSSNAEAAAFADAFFIAVGTPQKRGEFSADVSAIDSVVRTLAPMIDRPAVIFGKSTVPVGTAERFRRLAQELSPAGEDLELAWNPEFLREGYAIKDTLEPDRLVLGTYADGDGRAETVAREIYAQLLENGVPFITTDLATAELVKTSANAFLATKISFINAVAEVCEAAGADVVELADAIGYDHRIGRAFLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDNVNMRRRTQIVEMTRNVCGSLLGARVAVLGAAFKPNSDDVRDSPALNVAGQLQLQGASVLVYDPKAMDNSRKLFPTLDYATSAKDACDRADVVLVLTEWSEFRELDPTRLASVVRHPRVIDGRNCLDPQAWVNAGWQYRGFGRRKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV72</accession>
    <name>A0A132PV72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_01690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the extradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26259">
        <property type="protein sequence ID" value="KWX26259"/>
        <property type="gene ID" value="AFM11_01690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.348"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="140"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX26259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="290" mass="32551" checksum="CFA30E6C67848C53" modified="2016-06-08" version="1">MSYVVGTSSDVASWQEYATGVLGMEISRDSDDKLLYVRADDRHHRIGVRAGHEEDVAYVGWDVASREALESAAARLEDAGVAVTSGKPDEAADRRVMDFVHFTCPYSDVRMELVLGHEMVFRPPFRPTRDLAGFNTGDLGMGHVVLYTPDLYGAADFYCKILGFGVTDFAHLPSSEPFAVFLHCNSRHHSLAFMNIPGAPRRIQHVMFETVTMDDVGHSYDVCADRGITSTSTGRHHNDRVFSFYFRNPSGWHFEYGWGSRTVDPQSWTPENYTLKPGFAWGHDGLMRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV76</accession>
    <name>A0A132PV76_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25932">
        <property type="protein sequence ID" value="KWX25932"/>
        <property type="gene ID" value="AFM11_01210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.248"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="192" mass="21501" checksum="85CB9312D70437A6" modified="2016-06-08" version="1">MGIAAQEDYGAYRRSYRVNRAHDRRVGIAMVLLLFAPILFLWMAYDASPWSDNGMGPSTTGMLASGITGLIFLGLAAFVAAPLLAGMLRTRGAQLHVFERGAIAERARGNLYAWPYRRATARFVCWRESNEGEWRDRPQLWVTFHKDGDTICFDGLDPNDRAVLADIAREFGIADEPEQIDGIYRNTAPTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV84</accession>
    <name>A0A132PV84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TmrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01160</name>
        <name evidence="2" type="ORF">AWC31_34200</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843601.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34200"/>
    <dbReference type="EnsemblBacteria" id="KWX26230">
        <property type="protein sequence ID" value="KWX26230"/>
        <property type="gene ID" value="AFM11_01160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12106">
        <property type="protein sequence ID" value="ORX12106"/>
        <property type="gene ID" value="AWC31_34200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.238"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX12106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="211" mass="23819" checksum="86DB68B4B6C3CDF1" modified="2016-06-08" version="1">MLLWINGPFGVGKTQTAFELHRRLGGSVVCDPEFVGYGLHRTMPRHLRRDFQDLPAWRQGVFEVLDSTLRQYDGPVIAPMTVIEPRYFAETVGRLRDVGHDVFHFALLARRETVLNRLSDRGLGFGGLLRRTGKQDAALRREAFAVERLDRSLENLARPEFADQIWTDNLGIPEVAERIAGIAGVSLAPNTDGAVRARLRRTAVTLRHIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVB2</accession>
    <name>A0A132PVB2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02740</name>
        <name evidence="2" type="ORF">AWC31_35515</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843771.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26298">
        <property type="protein sequence ID" value="KWX26298"/>
        <property type="gene ID" value="AFM11_02740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12148">
        <property type="protein sequence ID" value="ORX12148"/>
        <property type="gene ID" value="AWC31_35515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.564"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX12148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="69" mass="7962" checksum="525A73AF9E38BCD2" modified="2016-06-08" version="1">MWDVRVERDIESYDLERLRAAFADVIAKRLAPGKRLLRVVTWCQDGGSLFRTKTGPRRYAVAYEVAFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVB8</accession>
    <name>A0A132PVB8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34480"/>
    <dbReference type="EnsemblBacteria" id="KWX26263">
        <property type="protein sequence ID" value="KWX26263"/>
        <property type="gene ID" value="AFM11_01730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.356"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="43"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="445" mass="46474" checksum="FCFD0A257C142929" modified="2016-06-08" version="1">MTVGRPYARADSVAGLRSAVRGRVLLDGDAGFDAARTPWNLTVDQSVRAVVDVVDADDAAALVRFARDAGVPIAVQPSGHGASNSLDGTILVRTAALDEIHVDTANRIARVGPGVSWGKVQALAGPAGLTGVAGSSPVVGVTGYTLGGGLSWFSRKYGWAAESVTAFDVITADGNRSTVTDHADPDLFWALRGGGGDYAFVTSIEFALKPAPSLYGGSMIWPASQAAAVISAFRDITASAPDELTAWCSLTRFPGAPALVRIDTTYLGPADAGAALLHPLDRIGGVLSDTRRVLAVTDIGTIVEEPTEPAPSRQQGVLVTELPDRFLDTLLTGSIEPLMTVQIRHLGGALQRPCAIPAGTVDTPYIVNFIGAEPNSQTGAALTTRTSVYLDTLTGVNTGKVPFNFLTPEQGAADAFDEATLARLREVKRVRDPRGVFRSNHPVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVF0</accession>
    <name>A0A132PVF0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carbonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_01635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843645.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26254">
        <property type="protein sequence ID" value="KWX26254"/>
        <property type="gene ID" value="AFM11_01635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.337"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="704"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX26254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="751" mass="77639" checksum="BCA7B4E65E3D3D7E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVI7</accession>
    <name>A0A132PVI7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843460.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26177">
        <property type="protein sequence ID" value="KWX26177"/>
        <property type="gene ID" value="AFM11_02815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.580"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="182"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="361" mass="39743" checksum="AC37C85D35FF01FD" modified="2016-06-08" version="1">MIRAAVITAGFPDYRRNFLSELRDAFAENGDELVLVGGDVYSDPTVRSAEFAGVVKLRNRHWLGRRILWQPGALRYLDGLDVVVVDLNPRSLTACLVLLISKVKRTRTLVWGHILPRAGASARTVPIRRAMRRFADGVISYTWTDAELVRTEDPGTDVWVASNGLYRASDLGWDPTTPRTDTIYVGRLEPAKKPELLVRAFAHARDRLPADARLRIVGDGSLRGRLEELAGELGIGADVIFPGHVSDLERLREFYSTAVVSASPGYVGLSLTQSLGFGVPMVVADDEPHAPEVELLNDVTGLYFTAGSVESLADKLVEVYTKPEAWDHEAIVRQVQNTYSSSAMADGFQRALRGISQDSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAR7</accession>
    <name>A0A132PAR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000055">
        <property type="protein sequence ID" value="KWX19425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043416444.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000055.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19425">
        <property type="protein sequence ID" value="KWX19425"/>
        <property type="gene ID" value="AFM11_35935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6265"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="174" mass="19728" checksum="FEB3EB5F0B11104A" modified="2016-06-08" version="1">MHIYVDETKQRDYLLVASVHVSTDLTGLRQMVRGLLLPGQRYLHMKDEKDGRKRTIAQAFVDAGVQATVYRAGPQHRNERQRRSACLQALVDDHAGLGEAHIILDEDETMVKFDNQKLIEYTRAAGCRDTLRYEHQRSHVEALLAVPDAIAWCWAKGGPWRTLIAPAVTAIRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAU7</accession>
    <name>A0A132PAU7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_35890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000052">
        <property type="protein sequence ID" value="KWX19438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067860015.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22510"/>
    <dbReference type="EnsemblBacteria" id="KWX19438">
        <property type="protein sequence ID" value="KWX19438"/>
        <property type="gene ID" value="AFM11_35890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6257"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="445" mass="47292" checksum="0AE4AC812C711516" modified="2016-06-08" version="1">MKVASPRGSLRNTHKYSWISLAVCWLIWILNAYDREIILRLGPTISEQFHFSPDAWGAIASLIMISLAVLAIPGSTLSDKYGGGWKRARFQVPLVIGYTALSFVSGLKAVSSHAVAFIALRVGVNLGAGWGEPVGVSNTAEWWPKERRGFALGVHHTGYPVGSLLSGLSAAVVIAVFGAANWSYTLFLGLIVAVPLMIFWGRYSTADRIATLYEDIADKGLTPPDGDLDRAAGGKGLISACFRNRCINLTALTTLLTQIVYMGINVVLPAYLYNVVGLSLAESAGLSVVFAFTGILGQILWPTLSDVIGRKTTIMICGIWMAISVACFYFATSSLLVVVIQLAFGLVANAVWPIYYAAASDAAPEGAVSTANGIITTAMFIGGGIAPLLMGRLISLGGGWTAHGGYIVCFFVMSACALAGVLLQLFLRPTESPENTQDEQLTASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBA2</accession>
    <name>A0A132PBA2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859439.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10860"/>
    <dbReference type="EnsemblBacteria" id="KWX19615">
        <property type="protein sequence ID" value="KWX19615"/>
        <property type="gene ID" value="AFM11_34715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5290"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="103"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="306" mass="31744" checksum="3F9064DB8178F50D" modified="2016-06-08" version="1">MTPLQRYIAEEIATDHLDGLLSRREALRRLALLGLSTAAATSLIAACSSTQQPTTETSATETATGSGPAASGPPPGSEGALPTEPVTWAGPAGELQGAWAEAPDAKGGVLVIHENKGLNDYIRSVAGRFAGIGYSALAIDLLSAQGGTAKFTDPADATAALSKIAPEESVANLKSGIDELQRRVPDRKLAAVGFCMGGGLVWRLLAVGTPQLAAAVPFYGPTPDNPDFSGSKDVAVLGFYGALDQRVNATEPVARAALEKAGLVHELVTEPDANHAFFNDTGDRYNAAAAADAWRRVQDWFATHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBC6</accession>
    <name>A0A132PBC6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859442.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10865"/>
    <dbReference type="EnsemblBacteria" id="KWX19616">
        <property type="protein sequence ID" value="KWX19616"/>
        <property type="gene ID" value="AFM11_34720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5291"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="308" mass="33089" checksum="77C7131D771952C0" modified="2016-06-08" version="1">MGWTPEPDALRGRVAVVAGATRGAGRGIAAALGEAGATVICTGRSSVAGNRTSDYDRPETIEETADLVSDLGGFGVAIQVDHLDVGQVRALAGRITADHGRIDILVNDLWGAEILKGAPPTWGRPMWQHDLDDGLRILRLGIDTHLITSHCLLPLLAREPGGLLVEISDGTTAFNIDNYRLSVFYDLVKNAVNRLAFSHGHELATFGATAVAITPGWLRSEMMLDNYGVTEANWRAALDPVRTDGYPMAPPGFAESETPRFVGRGVAAIAADPDRARWNQRSVSSIELAREYGFTDLDGRQPDAWAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBX1</accession>
    <name>A0A132PBX1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858888.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07955"/>
    <dbReference type="EnsemblBacteria" id="KWX19831">
        <property type="protein sequence ID" value="KWX19831"/>
        <property type="gene ID" value="AFM11_33800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5097"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="205"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="447" mass="48151" checksum="CACFEF90EAAC6CCE" modified="2016-06-08" version="1">MVTVTVPAASADEVVDLVSALIRFDTSNTGDPATTKGEAECAQWVAEKLQEVGYRTEYVESGAPGRGNVFARLPGSDPSRGALMVHGHLDVVPAEPADWSVHPFSGAVKDGYVWGRGAVDMKDMVGMSIAVARHFKRAGIVPPRDLVFAFIADEEHGGTYGANWLVDNRPDLFEGVTEAIGEVGGFSLTVPRKDGGERRLYLIETAEKGLSWMRLSARGRAGHGSMVHDDNAVTAIAGAVDRLGRHQFPLVLNPAVEQFLTAVAEETGYTFDVDSPDLEGTIAKLGGVARIVSATLRDTANPTMLKAGYKANVIPASAEAVVDCRVLPGRKEAFEREVDELIGPDVTRSWERDLPSYETTFDGDLVDAMNEAVLALDPDARIVPYMLSGGTDAKSFQRLGIRCFGFAPLRLPPDLDFAALFHGVDERVPVDALQFGANVLEHFLKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC83</accession>
    <name>A0A132PC83_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_34925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GtrA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859550.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02095"/>
    <dbReference type="EnsemblBacteria" id="KWX19592">
        <property type="protein sequence ID" value="KWX19592"/>
        <property type="gene ID" value="AFM11_34925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5714"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="8">
        <location>
            <begin position="42"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="9">
        <location>
            <begin position="302"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX19592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="427" mass="45752" checksum="DE17C8E1260C81D5" modified="2016-06-08" version="1">MTEIAERFDTEDADTDAQDRFHFASRPNAAVAARAAGVPVLDVVVPVYNEQAALAHSVRRLHRYLQENFGLPTRITIADNASVDATPRIAAELAAELDGVRVVRLEEKGRGRALHAVWSTSDAPVLAYMDVDLSTELTALAPLVAPLISGHSDLAIGTRLGRGSRVIRGAKREFISRCYNFILKSTLAARFSDAQCGFKAIRADVAERLLPHVADTGWFFDTELLVLAERSGLRIHEVPVDWVDDPDSRVDIVATATADLKGIGRLLRGFANGSIPVNTIAAQLGSSRNSAAPGSLLRQVVRFGAVGVVSTLAYLLLFVALRSGLGAQAANLVALLLTAIGNTAANRRFTFGIAGARNVTRHHLEGLTVFGIALTITSGSLGLLHALTPQPHPAVELAVLVAANLAATVVRFVLLRGWVFHPSRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCP0</accession>
    <name>A0A132PCP0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858188.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19790"/>
    <dbReference type="EnsemblBacteria" id="KWX20105">
        <property type="protein sequence ID" value="KWX20105"/>
        <property type="gene ID" value="AFM11_32655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4859"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="93" mass="10896" checksum="6F2302387282D4B1" modified="2016-06-08" version="1">MSRRRREPRRLPPLPPPRRIETGPDGYEYEVRAVTAARALKNYRCPGCDHEIRSGVAHVVVLPVELGDVDDRRHWHTSCWTNRANRSPTRRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCU2</accession>
    <name>A0A132PCU2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31955</name>
        <name evidence="3" type="ORF">AWC31_31940</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857813.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31940"/>
    <dbReference type="EnsemblBacteria" id="KWX20158">
        <property type="protein sequence ID" value="KWX20158"/>
        <property type="gene ID" value="AFM11_31955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12572">
        <property type="protein sequence ID" value="ORX12572"/>
        <property type="gene ID" value="AWC31_31940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4717"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035197">
        <property type="entry name" value="DUF5313"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17240">
        <property type="entry name" value="DUF5313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX12572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="138" mass="16333" checksum="6E8753F11C69F4C4" modified="2016-06-08" version="1">MAATKPNLFQYIAYSYGKRLPDSMRDWVAHDLADHGAIRRHMIRMAIPPLFVLAPFWLLPASLYVHIEMTVPIYIWALLMALALNKVWRRHRLAQHNLDPNLVDEIKYKKEAHIHEDYIRRFGPRPQEAKYQQNSSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCU6</accession>
    <name>A0A132PCU6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857998.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20047">
        <property type="protein sequence ID" value="KWX20047"/>
        <property type="gene ID" value="AFM11_32255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4780"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="295" mass="31820" checksum="E171A847AACE4A84" modified="2016-06-08" version="1">MIGFALPQFGTFGRQDLIQFATSAERLGAGSLWVGDRLLASVDPVTGVDGNAHIPRQFRRSFDPFVALSVAAAVTTTPLLGSSVLVAPWYPPVQFARQLTSIDVVSDGRLIAGLGIGWSPEEFEAAGASIGGRGAQLDELLDVLDSVWTAAPVRYAGRRWSMRPAWIDLKPAQKPHPPVYLSAFTPAALGRIGRRADGFLPVVRLPETQYVDEFRWQRQIIDSAAAAAGRDPAAVHTQVRVNVAHGTSIGEVADVVRKLADNGFPDAFVDLMYVTSSVDEMIEWAQSLLSARSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCX1</accession>
    <name>A0A132PCX1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857837.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31900"/>
    <dbReference type="EnsemblBacteria" id="KWX20166">
        <property type="protein sequence ID" value="KWX20166"/>
        <property type="gene ID" value="AFM11_31995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4725"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="327" mass="34457" checksum="EBAB510FE4B3D250" modified="2016-06-08" version="1">MRAALVKEFGPPSSIVVEDVADLHPGAGEVLIEVGAVSINFPDILVVEGTYQNLPARPFSPGKEAAGRVIAVGDGVSRVRVGQRVLALVEYGGYAEQLVVPEDLVMELPDGMSYEAAAAFGLVYSTAYFGLLRRGQLKPGETVLITGAGGGVGSAAVQLAKAWDARVIALAQDEAKAELARSQGADIALTSKPDTLRDDLLAATDGKGVDVVMDMLGGDFLTQIIRATAWEGRIVIVGFASGSQNPIKPGHILVKSISVIGLQSSDYRDRTPELMRSSMAEMFALYEQGKLDAAVDTTFPLDKVGDALQYVKDGRVRGKVVVTTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCX6</accession>
    <name>A0A132PCX6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857876.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31825"/>
    <dbReference type="EnsemblBacteria" id="KWX20179">
        <property type="protein sequence ID" value="KWX20179"/>
        <property type="gene ID" value="AFM11_32070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4740"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="247" mass="26222" checksum="D4EA610389752178" modified="2016-06-08" version="1">MHENARIALVTGASRGIGAEVAQQLAGPDTHVIVNYREKAKRADTIADTIRSAGGHASTLGADISDEAAAAAMIDDVAHRFGKLDVLVLNASGGLELGADPGYAMRLNRDAQRRLAQLAMPLMPAGAHIVFVTSHQAHFFPHKAVPKGYAPIAASKRAGETALYTMRHEFDRRGIHFTVVSGDMIDGTIIIKLLERRDPSAVEARRSKSPLPTVSEFAAAIANAATTPHPSGIVYVGGPDYLDRMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD18</accession>
    <name>A0A132PD18_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpD</name>
        <name evidence="13" type="ORF">AFM11_33315</name>
        <name evidence="14" type="ORF">AWC31_02400</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858632.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02400"/>
    <dbReference type="EnsemblBacteria" id="KWX19862">
        <property type="protein sequence ID" value="KWX19862"/>
        <property type="gene ID" value="AFM11_33315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13390">
        <property type="protein sequence ID" value="ORX13390"/>
        <property type="gene ID" value="AWC31_02400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4995"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="152"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="160"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX19862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX13390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="475" mass="51572" checksum="82BC946E72D40255" modified="2016-06-08" version="1">MTATAEKTAGRVVRITGPVVDVEFPRGAVPDLFNALHADITFGALAKTLTLEVAQHLGDNLVRCISMQPTDGLVRGVEVSDTGASISVPVGDGVKGHVFNALGDCLDDPGYGKDFEHWSIHRKPPAFSDLEPRTEMLETGLKVVDLLTPYVRGGKIALFGGAGVGKTVLIQEMINRIARNFGGTSVFAGVGERTREGNDLWVELADANVLKDTALVFGQMDEPPGTRMRVALSALTMAEFFRDEQGQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGELQERITSTRGRSITSMQAVYVPADDYTDPAPATTFAHLDATTELSRAVFSKGIFPAVDPLASSSTILDPAVVGDEHYRVAQEVIRILQRYKDLQDIIAILGIDELSEEDKQLVQRARRIERFLSQNMMAAEQFTGQPGSTVPLKETIEAFDKLTKGDFDHLPEQAFFLIGGLDDLAKKAESLGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD63</accession>
    <name>A0A132PD63_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857580.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26185"/>
    <dbReference type="EnsemblBacteria" id="KWX20275">
        <property type="protein sequence ID" value="KWX20275"/>
        <property type="gene ID" value="AFM11_31570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="133" mass="14436" checksum="915A8088033AFE0F" modified="2016-06-08" version="1">MERRQNGQGTDSPMALLRQMPALVVLERFPVPVLAIAADGAILFANSAFAEMVGHSADAVNAMNFAEIFHSLPADESAVSVVRAHADLIVELIHRDGSIVRARMSKSALLRGDDPVALATFQDLTERLWVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDA2</accession>
    <name>A0A132PDA2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_31490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857691.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26070"/>
    <dbReference type="EnsemblBacteria" id="KWX20309">
        <property type="protein sequence ID" value="KWX20309"/>
        <property type="gene ID" value="AFM11_31490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4203"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="137"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="230" mass="24666" checksum="1A0A4F73D3974242" modified="2016-06-08" version="1">MRIGVAGAGNVGRSVARELLDYGHKVLLIERERRSFEPQTVPAADWLLADACELSALEEAGTETCDVLIAATGDDKANLVVGLLAKSEFGVPRVVARINDIRNQWLFSQQWGIDVAVSTPGALVAGVEGAIDVGHLVRLMGLREGRAELTKLTLPEDNPVVGQRVDRLDLPADTALVTVVRGSKVILPKPDDVLEAGDEMLFVANRSSESSLLAAIHGREFLREVIGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDW6</accession>
    <name>A0A132PDW6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067085972.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00690"/>
    <dbReference type="EnsemblBacteria" id="KWX20528">
        <property type="protein sequence ID" value="KWX20528"/>
        <property type="gene ID" value="AFM11_30350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3968"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="119" mass="12582" checksum="D9FFFC18784C9731" modified="2016-06-08" version="1">MPKALPVIDMSAPVCCAPVAAGPLSDADALEVAMRLKALADPVRVKIMSLLFSSRPGEETSGHLAAVLDLAESTVSHHLGQLRKAGLVISDRRGMNVFHRVKPEALQALCVVLDPNCCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEP3</accession>
    <name>A0A132PEP3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856229.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32920"/>
    <dbReference type="EnsemblBacteria" id="KWX20809">
        <property type="protein sequence ID" value="KWX20809"/>
        <property type="gene ID" value="AFM11_28690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3619"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="149" mass="16334" checksum="6A4C86E9DAB1CE7B" modified="2016-06-08" version="1">MHLTRFTDLGLRTLMLLASGESEDRRVTTRTIAKGANASEHHVAKAVSRLAELGMVYARRGRVGGLVLTEAGREASIGWLVRELEGDREVIECGGDSPCPLIAACRLRRVLADAKEAFYRELDRYTVTDLTAGTSLPIVLQLTGERNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEV9</accession>
    <name>A0A132PEV9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein AFM11_28725</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28725</name>
        <name evidence="4" type="ORF">AWC31_32955</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856240.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32955"/>
    <dbReference type="EnsemblBacteria" id="KWX20814">
        <property type="protein sequence ID" value="KWX20814"/>
        <property type="gene ID" value="AFM11_28725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11508">
        <property type="protein sequence ID" value="ORX11508"/>
        <property type="gene ID" value="AWC31_32955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3624"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="169" mass="18905" checksum="5A57AC472C250686" modified="2016-06-08" version="1">MALKTDIRGMVWKYPDPFLIGREQIRQYAKAVKAMDPASHDEAAAADLGHDALVAPLTFASTLALLVQEHFFRHVDVGMETMQIVQVDQKFIYHKPLMAGDQLHAVMEIQSVDERFGADIVVTRNVCTNDDGEMVLEAYTTMMGHEGDNSIQVKWDPETGKVMRRAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEY5</accession>
    <name>A0A132PEY5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855707.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10320"/>
    <dbReference type="EnsemblBacteria" id="KWX20895">
        <property type="protein sequence ID" value="KWX20895"/>
        <property type="gene ID" value="AFM11_27790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3431"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="321" mass="34389" checksum="EE2112BDA0029927" modified="2016-06-08" version="1">MHEVAILAYDGMSGFESGLAAEIFGITELSGRFSADIPRPWYSIKLCAETPDVRMIGGATVHAGYGLSDLATADTVIIPSVRDVTEPLSPVLTDAIRAAHDRGARLVSICSGAFALAAAGVLDGRQATTHWIYVDLLQQKYPEIDVDPAPLYVDGGGVLTSAGCAAGLDLCLHIVRSDHGVRVANDIARRLVISPHRAGGQAQYIDSPVPEPAADGRIAASMEWALSHLDSPIALDDLASQSALSRRTYLRQFAKATGTTPIKWLIEQRIQASLALLESSSLSIEQIATRVGFESAVTYRHHFVRQLHTTPSDYRNCFAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF63</accession>
    <name>A0A132PF63_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855956.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20975">
        <property type="protein sequence ID" value="KWX20975"/>
        <property type="gene ID" value="AFM11_27710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3416"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="39"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="298" mass="32606" checksum="54B660470A879C73" modified="2016-06-08" version="1">MHAGQLPITVATVRSLVDEQFPAWRGRRIAPVARTGTVNAIYRIGRGLAARFLLQHENTEAAWQLLRTEVRAAAELRGRTRFATPAPVALGKPGHGYPMPWSVQTWVPGVDAANRDAGSSIGFATDLAEFIAGVRSIDTCGKQFSGHGRGGELKDHDAWMDTCFERSEGLLDVAALRRLWNEMRELPRGADADVMSHGDLIPGNILVSKERRLAGVLDVGGLAPADPALDLVSGWHLLEARPRAVLRECLACDGLVWQRGRAWAFQQAMGLVWYYASSHPALSRVGRRTLHRITAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF75</accession>
    <name>A0A132PF75_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855968.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10300"/>
    <dbReference type="EnsemblBacteria" id="KWX20980">
        <property type="protein sequence ID" value="KWX20980"/>
        <property type="gene ID" value="AFM11_27770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3427"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_7" evidence="1">
        <location>
            <begin position="39"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="123" mass="13257" checksum="CA5F31A41886453F" modified="2016-06-08" version="1">MAAGPDHHRGVTVTNNGPDMPGYVWASVTEAGVRELFPGIRLRSLWTGEHGASAHVVEMDPGASWVGKDIHEPGPEEVYVVSGTFNDGVRDYPEGSFIHAPAGSWHIPQTVTGCKLFVFYPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF95</accession>
    <name>A0A132PF95_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20877">
        <property type="protein sequence ID" value="KWX20877"/>
        <property type="gene ID" value="AFM11_27655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3405"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="157" mass="17979" checksum="E178C8B25E49D7C7" modified="2016-06-08" version="1">MVSLRPATADDFEFFFELHKQTLGPYVDQVWGWDDDVQRAHLQRTMNPERTQVIVADGIDIGRLNVEDQPGEVFLGLIEIAPPYQGRGIGAELIETLLDDAFARGKQVRLNVLRVNSRAYRLYRRLGFREVSCDDTAPEIRISMLAKPPRAGHLRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFC1</accession>
    <name>A0A132PFC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040135.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20692">
        <property type="protein sequence ID" value="KWX20692"/>
        <property type="gene ID" value="AFM11_29160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3716"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="391" mass="41185" checksum="E596601FE5D0B1C3" modified="2016-06-08" version="1">MSDPTGPLSGVRILDLSALAPGPFATMLLGDLGAEVITVEAPAAARSGSGLGALPGYGGERARRQGINPLYRSRRSLVLDLKQPQALEIALQLAQRSDVFVEGFRPGTCERLGLGYDTVAARNPAIVYCSLTGYGQSGELAMRAGHDLNYIAESGLLSATTRDGQRPGIPVNVVADFAAGGLLAAFGILAGLLGRQASGRGTHIDVSMYEGLLGLLQVVQSWTLASAPDPSWGRGLLSGAVPFYDCYRTADGQWLSVAALEPKFFANLCTALGRPDLISAYADQSRWGELRAAFEKTFSAASLAEWLARLEEVDTAVAPVRSLPDAFDAAQRRGLLDAPGVVGPLPRMSAWKPTAGSVVTRPGQHTREILDEIGLSPDEIETLRATGAVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFL2</accession>
    <name>A0A132PFL2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_27515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855514.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07450"/>
    <dbReference type="EnsemblBacteria" id="KWX21120">
        <property type="protein sequence ID" value="KWX21120"/>
        <property type="gene ID" value="AFM11_27515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3377"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="5">
        <location>
            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="277" mass="29807" checksum="89A08B25A8405125" modified="2016-06-08" version="1">MSTAQRQRDADRTAELTAALGAARARLARAAESAGRRVSEIELLPVTKFFPATDILILNQLGCLAFGESREQEAANKIKAVRAELPETPIRWHMVGRIQRNKARAVAAWAYAAHSVDSARLITALDRAAGEALADGVRTQPLRIYLQISLDGDTERGGVDVNDPELVDELCAAAHAADGLQFVGLMGIPPLDADPEEAFARLAAERERVQRHYRQRLELSAGMSGDLEVAVKHGSTCVRVGTALMGRRPLTSPSVVTPVTSSSQTSELPRSAEGSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFN7</accession>
    <name>A0A132PFN7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 3</fullName>
            <shortName evidence="5">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfC</name>
        <name evidence="8" type="ORF">AFM11_28585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856176.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32840"/>
    <dbReference type="EnsemblBacteria" id="KWX20792">
        <property type="protein sequence ID" value="KWX20792"/>
        <property type="gene ID" value="AFM11_28585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3597"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="29"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="106"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="545" mass="59143" checksum="DE88D219B8BB1C67" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFU5</accession>
    <name>A0A132PFU5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854936.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21201">
        <property type="protein sequence ID" value="KWX21201"/>
        <property type="gene ID" value="AFM11_26465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3162"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="107" mass="11053" checksum="C466BE7F7681E61A" modified="2016-06-08" version="1">MPTDYEKNLAVLTDHIVRLADKQQTAVSQITGANRSIVDPARNVLDTHGLACGATNLAVSAVEAARRTAGGKLLQVSTELGEKLTAAAANYENTDSAEAGNIDSCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFX9</accession>
    <name>A0A132PFX9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <shortName evidence="6">HMG aldolase</shortName>
            <ecNumber evidence="6">4.1.1.112</ecNumber>
            <ecNumber evidence="6">4.1.3.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_26530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22748"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:58276"/>
            <dbReference type="EC" id="4.1.3.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H(+) + oxaloacetate = CO2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="6"/>
    <dbReference type="EC" id="4.1.3.17" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854972.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22805"/>
    <dbReference type="EnsemblBacteria" id="KWX21213">
        <property type="protein sequence ID" value="KWX21213"/>
        <property type="gene ID" value="AFM11_26530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3176"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008428">
        <property type="term" value="F:ribonuclease inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010203">
        <property type="entry name" value="RraA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01935">
        <property type="entry name" value="NOT-MenG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="159" mass="16445" checksum="1D66C0CD5F5B65EB" modified="2016-06-08" version="1">MSIEPRATADLVDEIYPDVRSCDLQLQNYGGKKMFAGRITTVRCFQDNALLKSILSTPGNGGVLVVDGDGSLHTALVGDIIAGLAADNGWSGVIVHGAVRDAAALRTIDVGIKALGTNPRKGTKTGAGERDVEVSFGGVTFVPGEVAYCDEDGIVVIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFZ6</accession>
    <name>A0A132PFZ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cutinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_26760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855084.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22575"/>
    <dbReference type="EnsemblBacteria" id="KWX21251">
        <property type="protein sequence ID" value="KWX21251"/>
        <property type="gene ID" value="AFM11_26760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3223"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="336" mass="35770" checksum="00156E6FD514D141" modified="2016-06-08" version="1">MAKNARRKRHRILALIAAGAMALVVVLVVAIVVVVMRRPETPSAPPSAQPPAGVPAPPTTRKPRPEFQSADCPDVMMISIPGTWESSPTDDPFNPTQFPLSLMSNISRPMAEQFPPERLQVFTVPYTAQFHNPFSADKQMSYNDSRAEGTRATVKAMTDMNERCPLTSYVIAGFSQGAVIGGDVASDIGNGRGPVDQDLVLGVTLIADGRRQMGVGQDVGPNPVGQGAEITLHEVPTLSALGLSMTGPRPGGFGALNDRTFEICGTGDLICSAPEEAFSILNLPKTLETLSGSAAGPVHALYNTPQFWVENGQTATQWTLNWAKGLVENAPHPKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG82</accession>
    <name>A0A132PG82_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Stearoyl-CoA 9-desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_25925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854585.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35970"/>
    <dbReference type="EnsemblBacteria" id="KWX21358">
        <property type="protein sequence ID" value="KWX21358"/>
        <property type="gene ID" value="AFM11_25925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3049"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="297"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="378" mass="40869" checksum="98B35A75F19ED308" modified="2016-06-08" version="1">MAKNYIKISANVADTVRPTIAGAKENPGWHAVRNIVGRITTPLLPDDYLKLANPLWSARELRGRVLEVRRETVDSATLVIKPGWGFSFDYQPGQYIGIGVLIDGRWRWRSYSLTSSPVTGARTITITVKAMPEGFLSTHLVGGLAPGTVVRLAAPQGNFVMPDPAPASVLFLTAGSGITPVMSMLRTLVRREQITDIVHLHSAPTESDVMFGGELAALQEAHPGYRLQLRRTRTEGRLDLHRLGDEVPDWQDRQAWACGPEAMLNDAEKVWAAAGVPGNLHLERFAVSRAAPHGAGGTVTFERSGKEIEVDGATPLMDAGEKVGIRMPFGCRMGICQSCVVGLVDGHVRDLRTGVEHDPGTRIQTCVSAASGDCVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG95</accession>
    <name>A0A132PG95_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PASTA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_25905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854575.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21355">
        <property type="protein sequence ID" value="KWX21355"/>
        <property type="gene ID" value="AFM11_25905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3045"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453223" description="PASTA domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="4">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="141" mass="14182" checksum="1EFAECF0A8B13075" modified="2016-06-08" version="1">MKKLLAKAAVAVGLSGVPMGLLATGVAAADDYAGQTYADAQSALADAGMKGVVSTRSGDSLSDDDCVVTSSEQAPWLKGDDFAPVTDTVLLNLNCNAGVATAKASGNSAASPEGRAALKKAKDEAEQEQEQAAADQAKTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGB4</accession>
    <name>A0A132PGB4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">manB</name>
        <name evidence="9" type="ORF">AFM11_26095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854679.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35800"/>
    <dbReference type="EnsemblBacteria" id="KWX21385">
        <property type="protein sequence ID" value="KWX21385"/>
        <property type="gene ID" value="AFM11_26095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3084"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="159"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="269"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="378"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="462" mass="48400" checksum="DF8D049CA788643E" modified="2016-06-08" version="1">MSRPAAAVHSVIKAYDVRGLVGTELDDAFVADVGGAFARLVRAEGAEQVVIGHDMRSSSPSLSAAFAEGVTSQGLDVIRIGLASTDQLYFASGKLNCPGAMFTASHNPAAYNGIKLCRAGAKPVGKDTGLSVIADEVINGVPAHHGAAGAVTDRDVLADYGQFLRSLVDLSDLRPLRIAVDAGNGMAGHTTPAVLGPIAGATVLPLFFELDGTFPNHEANPLDPANLVDLQAYVLETGADIGLAFDGDADRCFVVDELGRLVSPSAVTALVAARELTREIGATVIHNLITSRAVPELVVERGGTPVRSRVGHSYIKGLMADTGAIFGGEHSAHYYFRDFWGADSGMLAALHVLAALGEQERPLSEIMADYQRYEASGEINFTVADAAACVDAVLKSFGSGIHSIDHLDGVTVDLGGGSWFNLRTSNTEPLLRLNVEARTAEDVEAIVDKVATQIRTVSEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGE2</accession>
    <name>A0A132PGE2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroshikimate dehydratase</fullName>
            <shortName evidence="1">DSD</shortName>
            <ecNumber evidence="1">4.2.1.118</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36241"/>
            <dbReference type="EC" id="4.2.1.118"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial two-domain DSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.118" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854722.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36195"/>
    <dbReference type="EnsemblBacteria" id="KWX21401">
        <property type="protein sequence ID" value="KWX21401"/>
        <property type="gene ID" value="AFM11_25700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3004"/>
    <dbReference type="UniPathway" id="UPA00088"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046565">
        <property type="term" value="F:3-dehydroshikimate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02238">
        <property type="entry name" value="DSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043700">
        <property type="entry name" value="DSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="417"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="598" mass="64869" checksum="7405573C25FB058C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGJ3</accession>
    <name>A0A132PGJ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TobH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854674.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35805"/>
    <dbReference type="EnsemblBacteria" id="KWX21384">
        <property type="protein sequence ID" value="KWX21384"/>
        <property type="gene ID" value="AFM11_26090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3083"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="359" mass="36765" checksum="5522AEB134BE8B61" modified="2016-06-08" version="1">MNAVDATVDLDDGDGLLAADRNGLLRAAAMAGAQVRATAAAFSEGTLEPLRSDHPPRTLIWVAGRGVAETAGTVLAAALGGSVATPIVVAAETPPWIGALDVLVVAGDDPGDPALVNAAATGVRRGARVLVVGLYEGPLRDVTAGRAVALAPRLWVPDDFGLTRYLAAGLAVLQVLDAGIHVDLATLADELDAEALRNSAGRELFTNPAKTLADRMSGYDVVLAGDTAATLALARHGAATMLRVAGEVVAAAGLADVLAAEGSGATRSVGSGAERSLFHDEQIDGPLPRRMRTFVVSTDVERPNVAARIGGFDDISVIGAEDVPELAGTALPMGRPEQQLAIMAVRLEMTAVYLKLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGU2</accession>
    <name>A0A132PGU2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_23870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853459.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24275"/>
    <dbReference type="EnsemblBacteria" id="KWX21578">
        <property type="protein sequence ID" value="KWX21578"/>
        <property type="gene ID" value="AFM11_23870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2132"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004707">
        <property type="entry name" value="MmpL_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00833">
        <property type="entry name" value="actII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="810"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="854"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="891"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="45"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="595"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="963" mass="104447" checksum="F9081697BBEDF937" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGX5</accession>
    <name>A0A132PGX5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23985</name>
        <name evidence="2" type="ORF">AWC31_24170</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853527.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24170"/>
    <dbReference type="EnsemblBacteria" id="KWX21599">
        <property type="protein sequence ID" value="KWX21599"/>
        <property type="gene ID" value="AFM11_23985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15646">
        <property type="protein sequence ID" value="ORX15646"/>
        <property type="gene ID" value="AWC31_24170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2156"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004260">
        <property type="entry name" value="Pyr-dimer_DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03013">
        <property type="entry name" value="Pyr_excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX15646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="163" mass="18514" checksum="26ED39223CF42D4D" modified="2016-06-08" version="1">MQTFLPCPDFADSAKLLDPRRLGKQRAETIQVLRALTVPGYGWRHHPAAAMWAGYEEALVRYGLAVCEEWLAHGHKDTTAATLLADLKAGTGIARVRQQRALARADELPPWIGDPAFHRSHKSSLLRKDPEFYRPHFPDVPDDLPYVWPVSDRQRRVPIRSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH50</accession>
    <name>A0A132PH50_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24205"/>
    <dbReference type="EnsemblBacteria" id="KWX21594">
        <property type="protein sequence ID" value="KWX21594"/>
        <property type="gene ID" value="AFM11_23950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2148"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="121" mass="13165" checksum="ABC31AF9DDDEDD0D" modified="2016-06-08" version="1">MDRPEQKQSASRARPYTLTGGRTRARIEIPIEASVEALVSSSELDWAPGDVHSVIVRLCASRPSIAEISAYAGLPIGVTRVLVGDLVESGHLRVHATLTDHTTATERRRLIERTLSGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH62</accession>
    <name>A0A132PH62_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854312.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21547">
        <property type="protein sequence ID" value="KWX21547"/>
        <property type="gene ID" value="AFM11_25420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2447"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046037">
        <property type="entry name" value="DUF5995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19458">
        <property type="entry name" value="DUF5995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="277" mass="30487" checksum="B064C68C15A63587" modified="2016-06-08" version="1">MAQHPPLTPLPSATTLDEVVDTIDSVIQWSIESSSRLGYFAALYKRITIAVRTAVADGVFEDGPRLQRLDVAFANRYFDALNGHFHPGSYAKPTRSWQVTFDAATRAEPIILQHMLAGINAHIGLDLGIATQESVPAARLWQLKTDFDRINAVLASQVTGIVVDINELSPALANIYAALMDNQILLINEAVRGFRDDAWRFATVLSVQPRFMRPVTIRLRDVRVARQGELIYDPPGVVGLIQWAVTAVGARESRDIVKNIRVLDEIANSPAPIATAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHB2</accession>
    <name>A0A132PHB2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853854.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23460"/>
    <dbReference type="EnsemblBacteria" id="KWX21703">
        <property type="protein sequence ID" value="KWX21703"/>
        <property type="gene ID" value="AFM11_24660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2293"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453078" evidence="1">
        <location>
            <begin position="31"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="236" mass="24934" checksum="2069F27D42341C99" modified="2016-06-08" version="1">MTRTKAVQLLCIAVLTAVLAGLGVTPTALAGGYRTITLTFVRHAQSAGNASGLIDTSTPGPPITELGRSQAIASAQKLAGNDYDGIFASTMIRTQQTAQPMADSLHEPVTVLPGLRELEAGVYEGQPEAAAADTYFGAPQQWLQGNRTARIPGSVDGNEFDARFDQAVQQIYDTGDDKPVAYSHGGAIMLWVSMNVGNPDPQLLRTHPLNNTSYVVVKGNPTDGWTLVDWDGVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHI6</accession>
    <name>A0A132PHI6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_23405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853170.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28130"/>
    <dbReference type="EnsemblBacteria" id="KWX21800">
        <property type="protein sequence ID" value="KWX21800"/>
        <property type="gene ID" value="AFM11_23405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2036"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="761"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="830" mass="86649" checksum="44C9189F317EC9E6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIA7</accession>
    <name>A0A132PIA7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852353.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04310"/>
    <dbReference type="EnsemblBacteria" id="KWX22089">
        <property type="protein sequence ID" value="KWX22089"/>
        <property type="gene ID" value="AFM11_21495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1647"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="156"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="322" mass="34492" checksum="B32FA61A83890B01" modified="2016-06-08" version="1">MWCYRLVAPYTFERTEAEKPAPESLSDGQVLLQFLAAGVCGSDLPGFRGTQGKLPGDTGRSAAEMNGFPIHEIVGEVLASRHPDHRAGDRVVGWASGFDGLMEHVVADGSGLASYDPALTPQLAVALQPMACVLYAMEQLGDLTGRHVAVIGQGSIGLLFSYAAKAFGARRVTGVDPVDRSAIAARFGVDTVVRATSDRWVGHLDGADRPHVVIEAVGHQVATLNHALSAAAFGGTVFYFGVPDDDSYPISMRTMLRNNLTLKSGVTLDRRRVLARADEFARQHPDLLPNYVTHTFGIDEVQSAFELACRPVPGRVKIAITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIE1</accession>
    <name>A0A132PIE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852915.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22024">
        <property type="protein sequence ID" value="KWX22024"/>
        <property type="gene ID" value="AFM11_22995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1952"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="313" mass="33471" checksum="28E86F94EE0DB63A" modified="2016-06-08" version="1">MDAGRLRMLRELADHGTVAAVAQVLSMTPSAVSQQLKILAKEAGVPLVEPDGRRLRLTDAGRVLVGHADAVLAALDRAKAEMDAYGTTPRGTVRVSFFPSGAAMLLAPLISGAARRGVTILGRDIDLPAAQAPAQLADFDVVVVHRDDRDMSPWGPRFESTELLREPLDILLPPGHWLAERDHARLAELADEEWVGVEGGLMVDDVLNSLTILSGIAPRIAQRVNDFRVAEELVHAGIGIALMPRHVRLARALVRLPISDITLARRVEAITRAGASARPAVAATLDVLRTVAGDITSAAAEHARGQSVRPARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIJ5</accession>
    <name>A0A132PIJ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22010</name>
        <name evidence="4" type="ORF">AWC31_04815</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852511.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04815"/>
    <dbReference type="EnsemblBacteria" id="KWX22170">
        <property type="protein sequence ID" value="KWX22170"/>
        <property type="gene ID" value="AFM11_22010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10610">
        <property type="protein sequence ID" value="ORX10610"/>
        <property type="gene ID" value="AWC31_04815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1750"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="52"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="155"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX10610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="386" mass="42604" checksum="3F9AE1A79E738476" modified="2016-06-08" version="1">MSTTTARRTLRIAMNGVTGRMGYRQHLVRSILPLRDSGLTLDDGSRVAVEPILVGRNADKLADMAAEHGIEHWTTDFGSVIADPTVDVYFDAQVTSRRVEALTAAIKAGKHVYTEKPTAETLTEAVELARMAENAGITAGVVHDKLYLPGLVKLRRLVDEGFFGRILSMRGEFGYWVFEGDGQPAQRPSWNYRAEDGGGITVDMFCHWNYVMEGILGKVEAVTAKAVTHIPTRWDEAHQPYQATADDAAYGIFELAGGIVAQINSSWAVRVHRDELVEFQVDGTHGSAVAGLRRCVAQHRSHTPKPVWNPDLPATEPFRDQWLDVPANADLDNGFKLQWEEYLRDLLAGRPHRYGLLSAARGVQLAALGLQSSAEGRRIEVPEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIZ1</accession>
    <name>A0A132PIZ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_20770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852071.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06185"/>
    <dbReference type="EnsemblBacteria" id="KWX22271">
        <property type="protein sequence ID" value="KWX22271"/>
        <property type="gene ID" value="AFM11_20770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1493"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453386" evidence="6">
        <location>
            <begin position="27"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="7">
        <location>
            <begin position="37"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="677" mass="71410" checksum="71EB0EFEED338801" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIZ8</accession>
    <name>A0A132PIZ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21195</name>
        <name evidence="4" type="ORF">AWC31_06560</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852217.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06560"/>
    <dbReference type="EnsemblBacteria" id="KWX22338">
        <property type="protein sequence ID" value="KWX22338"/>
        <property type="gene ID" value="AFM11_21195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09866">
        <property type="protein sequence ID" value="ORX09866"/>
        <property type="gene ID" value="AWC31_06560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1585"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="218"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX09866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="272" mass="28180" checksum="68DDB65F4345E883" modified="2016-06-08" version="1">MKVVVGYDGSPSANAAISTGSQLFPGAQAVILYLCTPPFGSKGLRARLRHSARNVDELIDLVDSESDGEAARLVETGVTLARAVGWTPEPLVKRTWAGEGLGLAQVAEELQPDVVIVGARGIGATEHKMGSVSDLVVHHAPRPVLVVSKHMVSAEHEAVVDGPIVVGVDGSVGADRAVQAAKQLFGDRDILTVAVEDGDTSDVEAAHHVRRFRGSGAGATADALVSFADEHRAAVLVVGSRGQSAVRKMLLGSVAAATLQRTYRPALVVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ14</accession>
    <name>A0A132PJ14_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_20880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852110.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06295"/>
    <dbReference type="EnsemblBacteria" id="KWX22291">
        <property type="protein sequence ID" value="KWX22291"/>
        <property type="gene ID" value="AFM11_20880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1515"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="270" mass="29407" checksum="E10911F57FC8FB44" modified="2016-06-08" version="1">MTSRNVLVYVGLLFGAVITLLPFVLGLLTSFTSAEQFATESPLSLPKPPTWENYLGLADAGFGRAIAVTAVVTSVILLGQLVFSVLAAYAFARLRFPGRDVLFWVYVATLMVPATVTVVPLYLMMAEAGLRNTFWALVLPFMFGSPYAIFLLREYFRSIPGDLINAARLDGANTLDVITHVVVPASRPILVTLALITVVSQWNNFLWPLVITSGSRWQVLTVATAGLQTQYNAQWTLVMAATTVAIVPLIVLFVALSRNIVRSIVVTGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJG4</accession>
    <name>A0A132PJG4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20200</name>
        <name evidence="2" type="ORF">AWC31_11515</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000036">
        <property type="protein sequence ID" value="ORX08751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851919.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11515"/>
    <dbReference type="EnsemblBacteria" id="KWX22476">
        <property type="protein sequence ID" value="KWX22476"/>
        <property type="gene ID" value="AFM11_20200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08751">
        <property type="protein sequence ID" value="ORX08751"/>
        <property type="gene ID" value="AWC31_11515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1375"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX08751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="187" mass="20650" checksum="9AC513A6C2F49929" modified="2016-06-08" version="1">MADHDYITYEEFGRRFFEIAVSEDRVGDAIGAIAGDAFEMGPIGQGPGKIAKVTARVQIQKPRVSRQVGDRISFSIRIPLEIDMVIDLRIDRPQFMVFGEIDLRATALAAEPLLLILDVKKPRPSDISIHVTSKSLRAEVLRILAGVDDEIKRFIAAHVAGEIDSPESEKAKVIDVARELDSAWTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJI8</accession>
    <name>A0A132PJI8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="10">PEP synthase</shortName>
            <ecNumber evidence="6 10">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_20395</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="6 10"/>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851953.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22508">
        <property type="protein sequence ID" value="KWX22508"/>
        <property type="gene ID" value="AFM11_20395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1413"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="25"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="367"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="464"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX22508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="762" mass="80744" checksum="2EC0826353F9B7B3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJT5</accession>
    <name>A0A132PJT5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="ORF">AFM11_19010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851589.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15100"/>
    <dbReference type="EnsemblBacteria" id="KWX22596">
        <property type="protein sequence ID" value="KWX22596"/>
        <property type="gene ID" value="AFM11_19010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1136"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="17"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="410" mass="44847" checksum="2C846084188404A5" modified="2016-06-08" version="1">MDQPYFTVEAELAGRLGRVGTIHTPHGDIHTPAFIAVGTQATVKSVLPETMKQIGAQAILANAYHLYLQPGPDIVAEAGGLGAFMNWPGPTYTDSGGFQVLSLGVGFKKVLAMDTQRVQADDIIADGKERLAVVDDDGVTFRSHLNGSTHRFTPEVSIGIQHQLGADIIFAFDELTTLVNTRGYQERSVQRTHEWAVRCLAEHQRLQESTPERPRQALFGVVQGAQYEDLRRQAAHGLTTIVGPNGEGFDGYGIGGALEKQNLATIVGWVSSELPADKPRHLLGISEPDDLFDAVAAGADTFDCVSPSRVARNAAVYSATGRFNITGARYKRDFTPIDAECDCYTCANYSRAYIRHLFKAKEMLSATLCTIHNERFVIRLVDQIRAAIVAGEFDELRAHVLGRYYGTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKJ6</accession>
    <name>A0A132PKJ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pvc16_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17960</name>
        <name evidence="4" type="ORF">AWC31_12030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851212.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12030"/>
    <dbReference type="EnsemblBacteria" id="KWX22823">
        <property type="protein sequence ID" value="KWX22823"/>
        <property type="gene ID" value="AFM11_17960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18719">
        <property type="protein sequence ID" value="ORX18719"/>
        <property type="gene ID" value="AWC31_12030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.947"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025351">
        <property type="entry name" value="Pvc16_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14065">
        <property type="entry name" value="Pvc16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pvc16_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="226" mass="25224" checksum="70B024502FE8072F" modified="2016-06-08" version="1">MIPEVDHALRTLIEREAVDPTEVDVEFDAPTKDWASRRNAPTIGVYLYDIREDLRRRERGLLNEYDGNRVTARHLPPRYFKLSYLVAAWTQRPEDEHQLLAALLSCFLRYEALPADVLTGSIAALGLPVPVTVALPPPEDRSFADVWTALGGELKPSLDIVVTAPTDTGRSFVAGPPVERPPRLRTNRMDASVGQESAQRRAVGDPAFGQEPAPGAVRVRKRQRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKK1</accession>
    <name>A0A132PKK1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851327.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22875">
        <property type="protein sequence ID" value="KWX22875"/>
        <property type="gene ID" value="AFM11_18425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1023"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="226" mass="24830" checksum="6DDB403402B8255A" modified="2016-06-08" version="1">MDWLPLLSTVGLPALSILATAGVTLGVKAIDLRARNQERRQEIAQDRSSRMWDAKRAVLEGIIGSCVRIRQACQQYADSNGNSEALTTTQRTEVLRALMQESKDLDRAPGGRGALVAWTEEPTRQAVEQLFDVIDAELQAHGSTLGNLRAALQLQSKAIAALPDDLGSPDTRQRIDDFRIYNAMVRDLTEEIGSKSSLDLEALKDLCDNVIREAREDLRGQHGPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKS6</accession>
    <name>A0A132PKS6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850590.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19980"/>
    <dbReference type="EnsemblBacteria" id="KWX22949">
        <property type="protein sequence ID" value="KWX22949"/>
        <property type="gene ID" value="AFM11_16340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.616"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="331" mass="36162" checksum="C521BDA2B984A1EA" modified="2016-06-08" version="1">MAVITRYPLVRHLRVEPTAHIRALRRGKLVQDGPGLAFWFRPLTAAMSEIPMDDRELPVLFHARTADFQDVAVQATVTYRIVDPTLAAQRIDFSIDTETGAWRAAPLEQVAGLLTESAQQHGLDLLARTTLTSALVDGISAVRKRMVDGLAADTRLAETGITVIGVRVVAIRPEPEVERALQTPTREQVQQEADKATFERRALAVERERAIGENELQTKIELARREEELVAQNGANDRLKTQEAWASDAIATEAKAKREVALAEAKAQAARLVGEAEAAAETARLAAYRDLSDATMLGLAVKELAANLPKIEHLVLTPDLLAPVLTRLSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKX9</accession>
    <name>A0A132PKX9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16650</name>
        <name evidence="3" type="ORF">AWC31_01220</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850702.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23001">
        <property type="protein sequence ID" value="KWX23001"/>
        <property type="gene ID" value="AFM11_16650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13183">
        <property type="protein sequence ID" value="ORX13183"/>
        <property type="gene ID" value="AWC31_01220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.680"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453381" evidence="1">
        <location>
            <begin position="32"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="206" mass="19196" checksum="797BC99E4EC7C63C" modified="2016-06-08" version="1">MKLTWKAFSTSMIAAAGALPVALALSATANAEPVPAPPAPGVPNVPIVNQLAGVPGAAPQLLQGVASALTGTPAAAPAPAPSATASVTLPQAPATVAQPALPTAPAATTAGAPAANGVANLIPSAEVKIPQVPGMPVPLPQQINIPGDLASLAPVGSQLANLAPTATSATAPVASAAAPAASVPTASAASAPGALALAPLLTAGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL73</accession>
    <name>A0A132PL73_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_17195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850897.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01760"/>
    <dbReference type="EnsemblBacteria" id="KWX23096">
        <property type="protein sequence ID" value="KWX23096"/>
        <property type="gene ID" value="AFM11_17195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.792"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="30"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="386" mass="42701" checksum="D347FE41692A5E60" modified="2016-06-08" version="1">MTLSKDVNEPPVQGGLESADVPRSPSGRVASLTGIRAVAALLVVLTHAAYTTGKYPQGYLGLVYSRAEIGVPIFFVLSGFLLFRPWVKASATGGPAPSVRRYAWHRVRRIMPAYVVTVLIAYLVYHFRTAGPNPGHTWEGLFRNLTLTQIYADNYLYSFLHQGLTQMWSLAVEAAFYVVLPLLAYVLLVVLCRRKWRPWLLLTGLAVTAAVSPVWLIIVHHTTGLPDGARLWLPTYLAWFVAGMALTVLAQMKLRGYAMVCVPLAVVSYFIASTPIAGEPTTSPAVLSEALVKTGFYAVIAALLVAPPALGDRGWYTRFLASRPMVFLGEISYEIFLIHLIIMELVMVEVMRTPVYTGSIVNLFVLTMAFTLPAAWLLHRFTRVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLU1</accession>
    <name>A0A132PLU1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="4 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_15990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4 8"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850424.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16565"/>
    <dbReference type="EnsemblBacteria" id="KWX23309">
        <property type="protein sequence ID" value="KWX23309"/>
        <property type="gene ID" value="AFM11_15990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7323"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="206" mass="21724" checksum="DBA9DE9F36347D3B" modified="2016-06-08" version="1">MPNSNPVSAWKALKDGNARFVAGEPQHPSQDIARRASLTHAQKPTAVVFGCGDSRVAAEILFDQGLGDMFVVRTAGHVIDNAVLGSIEYAVSILEVPLIVVLGHDSCGAVKAAINALDDGQVPGGYVRDIVERVTPSILMGRHAGISRVDEFEAWHVKETVSQLQMRSAAIAQGLAAGTQAIVGATYHLADGRVELRSHLGDIGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM20</accession>
    <name>A0A132PM20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_17000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850827.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01570"/>
    <dbReference type="EnsemblBacteria" id="KWX23062">
        <property type="protein sequence ID" value="KWX23062"/>
        <property type="gene ID" value="AFM11_17000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.753"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="224" mass="24547" checksum="3B7CA82B6284CC18" modified="2016-06-08" version="1">MKLVLQAVASGVFGLVFFGLALFGPAGTFDYWQAWVFIGVFLVATLIPSFYLAVKDPAALQRRLHGGPLAETRLVQKIAIWAIVVAILAVLIVSALDRRFGWSDVPTAVVILGDVLVAVGLILAQAVVFQNSFAGASIHVEDEQHVVSTGLYGLVRHPMYFGALLMMFGTPLALGSYWAMLATIASAPILGVRISDEEKMLRTELDGYDDYTRKVRYRLVPYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMY3</accession>
    <name>A0A132PMY3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849171.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03275"/>
    <dbReference type="EnsemblBacteria" id="KWX23700">
        <property type="protein sequence ID" value="KWX23700"/>
        <property type="gene ID" value="AFM11_12990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6690"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016676">
        <property type="entry name" value="P_lipid/glycerol_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016753">
        <property type="entry name" value="P_lipid/glycerol_ac_tran_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="141"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="355" mass="38683" checksum="40E9B0CA005F833E" modified="2016-06-08" version="1">MAGEPKAKVIPLHGNSSRASATRRAAQRTESARRHPSLLADPGTRASAEQIAAVVREIDQRRSAASGAPPVEDSPTELAKAIAAVSEFARKRMAGDYTVDEFGFDEHLTNAIFLPLLRVFFQNWFRVEVSGIENLPDTGAALVVANHAGVLPFDGLMAQVAVHDHHPSHRHLRLLAADLVFDLPMVGQAARKAGHTMACTTDAHRLLANGELTAVFPEGFKGLGKHFKDRYKLQRFGRGGFVSAALRAKAPIVPCSIVGSEEIYPMIADVKLLARLLGLPYFPVTPLFPLAGPAGMIPLPSKWHIRFGEPIDTTGYEEGAADDPMVTFELTDQVRETIQHTLYQLLAGRRNMFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN49</accession>
    <name>A0A132PN49_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12530</name>
        <name evidence="2" type="ORF">AWC31_02790</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848943.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02790"/>
    <dbReference type="EnsemblBacteria" id="KWX23627">
        <property type="protein sequence ID" value="KWX23627"/>
        <property type="gene ID" value="AFM11_12530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11078">
        <property type="protein sequence ID" value="ORX11078"/>
        <property type="gene ID" value="AWC31_02790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6596"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021784">
        <property type="entry name" value="DUF3349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11829">
        <property type="entry name" value="DUF3349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="100" mass="11195" checksum="9F4720EEDA43EDFC" modified="2016-06-08" version="1">MTESYMDNVLTWLHKGYPEGVPPKDYFALLALLKRSLSEDEVVQAAQAILRSNDGDTPVTDDEIRDAVHKIIEKEPNPEEIHQVASRLASVGWPLATPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN68</accession>
    <name>A0A132PN68_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation:proton antiporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Monovalent cation/H+ antiporter subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_13460</name>
        <name evidence="10" type="ORF">AWC31_03745</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849391.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03745"/>
    <dbReference type="EnsemblBacteria" id="KWX23776">
        <property type="protein sequence ID" value="KWX23776"/>
        <property type="gene ID" value="AFM11_13460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11237">
        <property type="protein sequence ID" value="ORX11237"/>
        <property type="gene ID" value="AWC31_03745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6786"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX11237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="95" mass="10211" checksum="79607F4A659C71C4" modified="2016-06-08" version="1">MSWVWIIAGIMLTAAAAVTMFRLLAGPSTLDRLVALDTLVAVTLCAIGTWAAFSLDTTVTYSLTALALISFVGSVSVARFRVPDTDNPRPKRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNB6</accession>
    <name>A0A132PNB6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiamine-phosphate synthase</fullName>
            <shortName evidence="9">TP synthase</shortName>
            <shortName evidence="9">TPS</shortName>
            <ecNumber evidence="9">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="9">TMP pyrophosphorylase</shortName>
            <shortName evidence="9">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiE</name>
        <name evidence="13" type="ORF">AFM11_13745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 10">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9 10">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 9 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849489.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03990"/>
    <dbReference type="EnsemblBacteria" id="KWX23820">
        <property type="protein sequence ID" value="KWX23820"/>
        <property type="gene ID" value="AFM11_13745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6845"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="12">
        <location>
            <begin position="13"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="9">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="9">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX23820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="223" mass="23380" checksum="4A37D76203CEADD6" modified="2016-06-08" version="1">MESPVDRLQHAALYLCTDARRERGDLAEFADAALAGGVDLIQLRDKGSPGEQKFGPLEARQELDALAVLADAARRHGALLAVNDRADIALAAGADVLHLGQDDLPLPVARGIIGDRPVIGRSTHDAEQVAGAIDEAVDYFCVGPCWPTPTKPGRPAPGLDLVRHTATLNPAKPWFAIGGIDAQRLPEVLAAGARRIVVVRAITAADDPRAAAHDLKKALSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PND5</accession>
    <name>A0A132PND5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849529.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29735"/>
    <dbReference type="EnsemblBacteria" id="KWX23840">
        <property type="protein sequence ID" value="KWX23840"/>
        <property type="gene ID" value="AFM11_13860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6868"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="112"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="318" mass="33249" checksum="E3C8487EC42C35A4" modified="2016-06-08" version="1">MIRLIATLFGVAAFGIAAAGLAVRYLPLGRHSVLLAATASPYLMLAAPVAVLLLALSRRWVLTALAVLLALAFVGIQTPHYLGPEPAAAPSASVRVLTSNLGMGLGDPAAVVASARKSADVVVLQELTPEAADGLAAAGLDDTFPHRISNPEPLAGGIGIWSRFPLVDTAHVPGYSLAMVRARLQVPDVAVDPIVLGIHFAAPWPAPIGPWAQDMEKFPTLLRELSHEAGSGAVIVAGDFNATHDMLPFRKLLDTGYRDAGEQAGAGMARTFPVGPRRVPAIGIDHVLLRNANATAVRREFIPGADHMALIADVEIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNM8</accession>
    <name>A0A132PNM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_11225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848114.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30670"/>
    <dbReference type="EnsemblBacteria" id="KWX23941">
        <property type="protein sequence ID" value="KWX23941"/>
        <property type="gene ID" value="AFM11_11225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6322"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="471" mass="49791" checksum="912E7106538C48F0" modified="2016-06-08" version="1">MPNLLKSNRITNWDPEDTVAWEAGNKFVARRNLIWSVFAEHIGFSIWSIWSVMVLFMPEAVYGFSAGDKFLLGATATLVGGCLRIPYTLATATFGGRNWTVFSAFVLVVPTTMTLVLMANPGLPLWPYLLCAALAGFGGGNFASSMTNINAFYPQRLKGWALGLNAGGGNIGVPMIQLVGLLVIATAGNRAPYWVCAIYLVALAVAGIGAALYMDNLEQHKIDLGAMKAILSERDTWVISLLYIGTFGSFIGFAFAFGQVLQINFAAGGQTPAQASLHAAQIAFIGPLLGSLSRVYGGKLADRIGGGRVTLAVFGGMILAAGLLVGISVVDDHSTGAATGLMMAGYVVGFIALFLLSGLGNGSVYKMIPSIFEARSHSLQVSEEERQKWSLSMSGALIGFAGAIGALGGVGINLALRQSYLSSGSATAAFWIFLAFYVLASVVTWVRYVRRPVATQVTIDESQRHASAIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNX2</accession>
    <name>A0A132PNX2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_11780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848425.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30250"/>
    <dbReference type="EnsemblBacteria" id="KWX24038">
        <property type="protein sequence ID" value="KWX24038"/>
        <property type="gene ID" value="AFM11_11780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6434"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="21"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="491" mass="51947" checksum="6E86FC5FA978ABDF" modified="2016-06-08" version="1">MTQSVDVAKTDYDKLFIGGHWVEPSTSEIIEVFSPATGEKVGQVPLAAEADVNAACAAARKAFDEGPWPRMSPAERQAVLAKTVELVNARADEFKHLLKLETGQPPTIVDMMQFGAGVSGLQYYAGAADKFAWKDIRDGIYGQTMVLKEPIGVVGAVIAWNVPFFLACNKLGPALLAGCTVVLKPAAETPLTTNLFAEVFAEAGLPEGVLSIVPGGVETGRALTNNPELDKFTFTGSSAVGKEIGKIAAEKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSGLMNSGQACVGQTRILAPRSRYDEVVEKLAAAAAGMQAGLPDDPTSMIGPLISEKQRERVEGYIKKGVEEGARIVTGGGRPEGLDSGWFVEPTVFADVDNSMTIAQEEIFGPVLAVIPYDTEDDAVRIANDSPYGLAGSVYTTDFGKAMEIASKIRTGTYAVNMYAFDPGAPFGGYKNSGIGRENGPEGIEAYTQAKSVLLPFGYTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP54</accession>
    <name>A0A132PP54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12235</name>
        <name evidence="6" type="ORF">AWC31_09740</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848663.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24119">
        <property type="protein sequence ID" value="KWX24119"/>
        <property type="gene ID" value="AFM11_12235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09217">
        <property type="protein sequence ID" value="ORX09217"/>
        <property type="gene ID" value="AWC31_09740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6526"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="193" mass="21231" checksum="E50BD78ACD4C2907" modified="2016-06-08" version="1">MAKTVSPRGFARERVLEAALGLFAEHGVNGTSLQMIADRLGVSKAAVYYQFHSKDDIVLAVVQPVFDDMIRLVRIAEAMSTPEARREAAVSGMVELSVRHRRVTAIFHGDPVIDSLVHTRAELQSTIERLTAILLGPDPDTASRIVMSMLMSGVYGSATDPELNDVNDDDLHRVLLDCTQRLLREPARPVVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPU1</accession>
    <name>A0A132PPU1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24358">
        <property type="protein sequence ID" value="KWX24358"/>
        <property type="gene ID" value="AFM11_10320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6101"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="575" mass="60306" checksum="405DDFEB6B290870" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPV3</accession>
    <name>A0A132PPV3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ORF">AFM11_09570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847183.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05655"/>
    <dbReference type="EnsemblBacteria" id="KWX24237">
        <property type="protein sequence ID" value="KWX24237"/>
        <property type="gene ID" value="AFM11_09570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5951"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="140" mass="15045" checksum="F1DF67E79F246460" modified="2016-06-08" version="1">MTERTLVLIKPDGVKRQLVGEILSRIERKGLTLAALELKNISDDLARQHYAEHEDKPFFGSLLEFITSGPVVAAIVEGPRAVAAFRQIAGGTDPVEKAVPGTIRGDLALVTQDNLVHGSDSLESAAREIALWFPGEATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPZ6</accession>
    <name>A0A132PPZ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10645</name>
        <name evidence="2" type="ORF">AWC31_19160</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX16962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847726.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19160"/>
    <dbReference type="EnsemblBacteria" id="KWX24411">
        <property type="protein sequence ID" value="KWX24411"/>
        <property type="gene ID" value="AFM11_10645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16962">
        <property type="protein sequence ID" value="ORX16962"/>
        <property type="gene ID" value="AWC31_19160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6169"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX16962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="75" mass="8273" checksum="EFA006A5DABA086F" modified="2016-06-08" version="1">MKVKLDRTMCDGFGLCAKHAPEYFPLDDWGYASLEGTGAVPAEDEDAVKRALLDCPVHAIIELKDKRRRPAGEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ84</accession>
    <name>A0A132PQ84_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_10380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847594.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18815"/>
    <dbReference type="EnsemblBacteria" id="KWX24367">
        <property type="protein sequence ID" value="KWX24367"/>
        <property type="gene ID" value="AFM11_10380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6113"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="DUF1729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="12">
        <location>
            <begin position="43"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_KS" evidence="11">
        <location>
            <begin position="2582"/>
            <end position="2989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1733"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2404"/>
            <end position="2436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX24367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="3077" mass="326602" checksum="360789FD36E8603F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQE5</accession>
    <name>A0A132PQE5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_07695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846078.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24560">
        <property type="protein sequence ID" value="KWX24560"/>
        <property type="gene ID" value="AFM11_07695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5388"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="216" mass="22999" checksum="7B6DEFE536D71230" modified="2016-06-08" version="1">MAAAIRVLIVDDQRLVRAGLRMLCESTPDLEVVGEAADGAEAARAAAELAPDVILMDLRMPGVDGITATRHVISARPEAKVLALTTFDDDDHLYPVLAAGAAGFLVKDTSPAELVDAIRRTAAGDFALSPHLLRRLVNRAVDAQLLDSSPSSDAVPLTPRELEVLPLVVDGLSNQEIADRLHLGVTTVKTHVANLMDKTGAQNRVQLAVYGCRRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQI6</accession>
    <name>A0A132PQI6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_07720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846091.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24345"/>
    <dbReference type="EnsemblBacteria" id="KWX24565">
        <property type="protein sequence ID" value="KWX24565"/>
        <property type="gene ID" value="AFM11_07720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5393"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="247" mass="27973" checksum="63A4F430C92D9C55" modified="2016-06-08" version="1">MAQSQHIRRARTGNGILGFVEPLLHFAGNFWWLIFPLGGMIGGGIKAVAAANERRAERRLERYRIKQQTKIEMARAAGAAKSADAAHQREMTKVLEQHDRTNARWLDYEIDIAKLLDFPVMTDMRDPLTIAFHKARSRADLLRPDDVGDLDRAAQLEYRDAVHEYVTAFDIAEAEAIRRRRSDFSAEAQERLARAQQLLRLASDDGATPQERQNAYTRAQKELDGLVVLPVTTRASIERKILGELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQK4</accession>
    <name>A0A132PQK4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kanamycin biosynthetic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846061.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22160"/>
    <dbReference type="EnsemblBacteria" id="KWX24554">
        <property type="protein sequence ID" value="KWX24554"/>
        <property type="gene ID" value="AFM11_07665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5382"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="62" mass="6770" checksum="8494A20CA0F9D146" modified="2016-06-08" version="1">MGFLDKVKDTLSKNADKVDSAIDKAGDIVDKKTQGKYAQHVDKAQDAAKNAIRKDDPQAPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQK7</accession>
    <name>A0A132PQK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08025</name>
        <name evidence="2" type="ORF">AWC31_24625</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000014">
        <property type="protein sequence ID" value="ORX15213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846244.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24625"/>
    <dbReference type="EnsemblBacteria" id="KWX24619">
        <property type="protein sequence ID" value="KWX24619"/>
        <property type="gene ID" value="AFM11_08025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15213">
        <property type="protein sequence ID" value="ORX15213"/>
        <property type="gene ID" value="AWC31_24625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5455"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX15213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="150" mass="16795" checksum="6A6C3C47DC1F6735" modified="2016-06-08" version="1">MAAPLLQAQIDINAPVDRVWALVSDLRRMPEWSPQCRLMKTLGPVRPGARTFNLNRRKFMFWPTTSRITEVIPEQKLAFRVDANNTIWTYELEPTETGTKLIESRHAENGTSAVSNALVNALFGGVPSFENELVEGMNASLARIKAAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQZ6</accession>
    <name>A0A132PQZ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_08475</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846474.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00330"/>
    <dbReference type="EnsemblBacteria" id="KWX24694">
        <property type="protein sequence ID" value="KWX24694"/>
        <property type="gene ID" value="AFM11_08475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5543"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="13">
        <location>
            <begin position="28"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX24694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="391" mass="41608" checksum="B40A6ADD084A78D5" modified="2016-06-08" version="1">MTLTAPPADTTRSGLQIGSIALRSPVVLAPMAGVTNVAFRTLCRELEVARAGTVSGLYVCEMVTARALVERHPVTMHMTTFAPDESPRSLQLYTVDPETTYRAAKMIADEGMADHIDMNFGCPVPKVTKRGGGAALPYKRRLFGQIVAAAVRATEGTDIPVTVKFRIGIDDAHHTHLDAGRIAAEEGAAAVALHARTASQRYSGTADWDQIAALKAHVTTVPVLGNGDIFEADDALAMMAATGCDGVVIGRGCLGRPWLFAELSAAFNGRPIPTPPTLGEVADIVRRHGELLSEHFGEDKGMRDIRKHVAWYLHGFPAGADLRRSLALVKTLRELDELLDQVDRDAPFPPAATGPRGRQGSAASVSLPEGWLDDPDDCAVPTGADVMHSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQZ7</accession>
    <name>A0A132PQZ7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_08850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846648.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13520"/>
    <dbReference type="EnsemblBacteria" id="KWX24756">
        <property type="protein sequence ID" value="KWX24756"/>
        <property type="gene ID" value="AFM11_08850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5618"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="68" mass="7703" checksum="EE4F5715CF41C7E9" modified="2016-06-08" version="1">MGCYRVELDEDLCQGHAMCELEAPDVFKVPKRGVVEIVDPEPPDEIREDVERAVEMCPTQAISIKEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRA9</accession>
    <name>A0A132PRA9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08735</name>
        <name evidence="3" type="ORF">AWC31_13635</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846587.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13635"/>
    <dbReference type="EnsemblBacteria" id="KWX24737">
        <property type="protein sequence ID" value="KWX24737"/>
        <property type="gene ID" value="AFM11_08735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18355">
        <property type="protein sequence ID" value="ORX18355"/>
        <property type="gene ID" value="AWC31_13635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5596"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="207" mass="22100" checksum="6CE51E93230E0916" modified="2016-06-08" version="1">MRSRYLPYATRPGRLLAQLFSDVAVIIWTAVWVLVGMAVYSAVATIAEVGRQVETGANGVADNLSSAGDNTDDFPLVGDTLSKPLRAASDAALDIAGAGHNLDTTASWLAWVLALAVAGAPILFVAMPWLYLRVRFFRRKWTAITLASTAAGEQLLALRALANRPLAKLTAVSDDPVGAWRSQDPTAIRGLAALELRSAGMSLRRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRI1</accession>
    <name>A0A132PRI1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_05705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845072.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11565"/>
    <dbReference type="EnsemblBacteria" id="KWX24933">
        <property type="protein sequence ID" value="KWX24933"/>
        <property type="gene ID" value="AFM11_05705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4332"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="106" mass="10902" checksum="BFBCFFE0204F6032" modified="2016-06-08" version="1">MSWLILGLAGLVEIAWSQSIKPTDGFTRPLPTLLCVVIGALSVYLLSLAMRTLPVGTAYAVFTGIGAVGAIVLGVLVHKDPLSAARALALSMIVGGIVLARFTTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRU1</accession>
    <name>A0A132PRU1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_06450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845310.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29225"/>
    <dbReference type="EnsemblBacteria" id="KWX25061">
        <property type="protein sequence ID" value="KWX25061"/>
        <property type="gene ID" value="AFM11_06450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4483"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="447" mass="47878" checksum="3A52CBE5CA8B567C" modified="2016-06-08" version="1">MDHNRLEYLDQATYLSLRATGRAQLAQSVWVYERPLDYAGLKTFHQNFGYGLAGRRIEHSALPFGRHRWVSSVGPATEIDIAEDARPRTALSDWIDERAEQPVDPQRGPGWHLGVLPMTDGSTAVSLVGSHCLFDGLGFLQTIADAVNGTVRAFGYPPPRSRTRRRAIIDDAIQTARDLPALGGALAAGVKLARAARHEQSASASPAAVPPGATGADDHRGIVVPTVTVFVDIAAWDRAAEERGGNSHSLLAGLSSRLGTRLNRRRADDGTVALLIAISDRAPDDTRANALRFARVNVEAATASTDLKTPRAAIRSALAELRETPDETFALLPLTPFIPKRAVKRMGAMVFGDLPVSCSNLGDVDPAVGRVDGTDADYVMWRPVDQNVKRAQIEGAGGQLVLAAGRITGKISISVVAYQPGAPNTKAWLRTLAGEVLDEFGLTAEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRU7</accession>
    <name>A0A132PRU7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845181.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29605"/>
    <dbReference type="EnsemblBacteria" id="KWX24994">
        <property type="protein sequence ID" value="KWX24994"/>
        <property type="gene ID" value="AFM11_06055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4403"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="155" mass="17364" checksum="25720196B00E0757" modified="2016-06-08" version="1">MTYRVIRLTEADWRLFAVLRLRALADSLGVDDQHYRRESRFTAAQWRRRLRDHAQFTAAVDGRAVGLIGAQQQNAHTMYLYSLWVDPAARGDGLAHRLIGAAVDWSRGRRVQTVKLRVASDNAAARCVYESLGFDVADAESSSGAEELAMTLRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRV4</accession>
    <name>A0A132PRV4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845356.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29065"/>
    <dbReference type="EnsemblBacteria" id="KWX25088">
        <property type="protein sequence ID" value="KWX25088"/>
        <property type="gene ID" value="AFM11_06610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4519"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="44"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="486" mass="53477" checksum="46748347D031EA43" modified="2016-06-08" version="1">MLLGPVEIASIDEWTPEPGSLISWQPTEAALAKAREAPESPVPASYIQTRHLRSFVEQGSRGVDHSRLFIAACDMPGRCDIRAMTYVINAHLRRHSTYRSWFEYRRADDPGTADTVVRHTMTDAADIEFVPKRHGAADAAKLRSQVAATPDSLQWDSFRFGVIQREDKFTFWSSIDHLHVDGQFVGVGLLEFQAMYSTLVSGAPPLQLPDAGSYDEYCLRQREFTSSLTLDTPEVQTWKSFAEKNNGTFPVFPLPLDDGSPSEGGDLVAVKLMDRQQTERFEDLCVAAGSRFIGGLFAAVAHALHELTGLDTYYGLTPIDTRTPDELTTQGWFTGLIPVVVPVAGASFADSIRAAQRDFDTGRSAALVPFERVVELAPHLTPPQPLFPMLNFFDASSGPMAPLLTNLQEGVRIATLSDGRVTYPLSTLVGRFNETFATVVFPKNPVARQSVDRYVAALQEVCDRVTGGRDVLVAATRNEAEGQPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRX5</accession>
    <name>A0A132PRX5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845422.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28955"/>
    <dbReference type="EnsemblBacteria" id="KWX25108">
        <property type="protein sequence ID" value="KWX25108"/>
        <property type="gene ID" value="AFM11_06720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4543"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="127" mass="13968" checksum="CAA4C3792FC29535" modified="2016-06-08" version="1">MTLTIGEVARRTGVAQTTLRYYERVGLIPPPERAGGQRRYQESVLVRLEVIRLCKAAGFSLDEITVLMADVTPGRPRARALAEAKLIEIDAQMRSLARARDIIEWGMKCTCPSIDACTCGIHDAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRY6</accession>
    <name>A0A132PRY6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846765.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13305"/>
    <dbReference type="EnsemblBacteria" id="KWX24792">
        <property type="protein sequence ID" value="KWX24792"/>
        <property type="gene ID" value="AFM11_09065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5662"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="131" mass="13840" checksum="00D330CEA1D8230A" modified="2016-06-08" version="1">MAIQPISAVVEIVASDLSRAVEFYRLLGLDVPDPDGPHVEVVLPGGNKLAFDTEEVIAGMHAGWTPPISSGRVAIAFGLNAPSDVDELYERLTAAGHPGTLKPFDAPWGQRYATVEDPDGTSVDLYAPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS38</accession>
    <name>A0A132PS38_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_06590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845348.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29085"/>
    <dbReference type="EnsemblBacteria" id="KWX25084">
        <property type="protein sequence ID" value="KWX25084"/>
        <property type="gene ID" value="AFM11_06590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4513"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="50"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="323" mass="34807" checksum="1BD8B2B4BA51BE83" modified="2016-06-08" version="1">MPTVPELADAIRAGDRAALARAITLVESTRADHRDQAQELLLQLTADAGKALHVGITGVPGVGKSTTIEALGMYLIEAGHRVAVLAVDPSSTRTGGSILGDKTRMARLAVHPDAYIRPSPTSGTLGGVAKATRETIVLLEAAGYDVILVETVGVGQSEVTVSNMVDTFVFLTLARTGDQLQGIKKGVLELADIIVVNKADGEHAIEAKGAARELTAAIRLIYPRETLWRPPVLTMSAVEGTGLPELWDTVLKHRRVLTEAGEFDARRRAQQVDWTWTMVRDTVLDRLMSHPEVRSIRAEVERRVREGELTPALAAQQILDAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS39</accession>
    <name>A0A132PS39_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29545"/>
    <dbReference type="EnsemblBacteria" id="KWX25007">
        <property type="protein sequence ID" value="KWX25007"/>
        <property type="gene ID" value="AFM11_06130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4418"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="133" mass="14165" checksum="AD434DDFF28C39D5" modified="2016-06-08" version="1">MVMAAVIAIGGFAVTKIRGIFGTQQLPTYAGSMSDDQKNVSDPKRVVYEIFGPPGAVADVNYIDDDGEPNQVDGVALPWSVEIVTNAPSMTGNVLAQGNSDFIGCRISSDGEVKDERTSHDVNAYIYCFAKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS63</accession>
    <name>A0A132PS63_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Xylulose kinase</fullName>
            <shortName evidence="3 5">Xylulokinase</shortName>
            <ecNumber evidence="3 5">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xylB</name>
        <name evidence="8" type="ORF">AFM11_07155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845643.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17560"/>
    <dbReference type="EnsemblBacteria" id="KWX25186">
        <property type="protein sequence ID" value="KWX25186"/>
        <property type="gene ID" value="AFM11_07155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4630"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="243"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="465" mass="47559" checksum="D872E15C593605BB" modified="2016-06-08" version="1">MSLVAGIDSSTQSCKIVVCDAESGAVVRSASAPHPGGTEIDPHRWWDALQTTVSAAGGLDDVAAISVGAQQHGMVCLDRNGQVVRDALLWNDTRSASSAADLVEELGGAAEWAKAVGVVPVASITATKLRWLADNEPEHADATAAVCLPHDWLSWRLSGSTDLADLRTDRSDASGTGYFSAETDTYRPDLLELAMRGRRPAVPAVVGPRDAAGRLPNGAVIGAGAGDNAAAALGLGAGPGDCIVSLGTSGVVSAVGSAAPHDAEGIVAGFADATGRQLPLVCTLNGAPVLAASAAMLRVDFDEFDRLALSAPPGAEGLTLVPYLEGERSPNLPRARGALHGVTVGNFNSANVARASVEGLLSSMAYCIDKIVGYGVDIERVILVGGGARSEAVRRIAPAILGRPVEVPPPGEYVALGAARQAAWALAQQDSPPSWTPGLVTPYTATPTPQVVEQYLAAQPLTLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSF1</accession>
    <name>A0A132PSF1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845448.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28885"/>
    <dbReference type="EnsemblBacteria" id="KWX25117">
        <property type="protein sequence ID" value="KWX25117"/>
        <property type="gene ID" value="AFM11_06765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4552"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="32"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="3">
        <location>
            <begin position="487"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="719" mass="79212" checksum="74BF3EEA5B913077" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSG3</accession>
    <name>A0A132PSG3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ester cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_06275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845843.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29400"/>
    <dbReference type="EnsemblBacteria" id="KWX25250">
        <property type="protein sequence ID" value="KWX25250"/>
        <property type="gene ID" value="AFM11_06275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4449"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="129" mass="14653" checksum="59B336487D25836A" modified="2016-06-08" version="1">MEASTAGIYRRYLECLNDRRWDDLGEFVCADVIHNGNSLGLSGYREMLESDVAAIPDLRFDADLIVVQDDLLAGRLLFQCTPQREFLGFQPSGTRVSFTEHVFYRFRDAKIAQVWSAIDTRTVAAQTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT00</accession>
    <name>A0A132PT00_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07020</name>
        <name evidence="3" type="ORF">AWC31_17695</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845539.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17695"/>
    <dbReference type="EnsemblBacteria" id="KWX25162">
        <property type="protein sequence ID" value="KWX25162"/>
        <property type="gene ID" value="AFM11_07020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17525">
        <property type="protein sequence ID" value="ORX17525"/>
        <property type="gene ID" value="AWC31_17695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4603"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="200" mass="20579" checksum="E0279A218A69225B" modified="2016-06-08" version="1">METTAPPSLLPHLWKATLVSGVLAIILGILVLVWPGITILVAAIFFGAYLLITGIAQVVFAFSLHVTAGGRVLLFISGAAALILAVLCFRSLQDSILLLAIWVGVGFVFRGVATAVSAISDPTLPGRGWEIFFGVISLLAGVVMLAAPFESLATLAIVVGAWLIVLGVFEVISAFGIRSGAKKLGSALQSPSSPSAPAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT25</accession>
    <name>A0A132PT25_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25489">
        <property type="protein sequence ID" value="KWX25489"/>
        <property type="gene ID" value="AFM11_04375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2751"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453613" evidence="2">
        <location>
            <begin position="28"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="416" mass="41718" checksum="6778471E90D2DB86" modified="2016-06-08" version="1">MSISMDKVTRAGIVGAVASAMAVGAFGATAPAHAWCVGISGINIGGGCSSTLGNFALGLGPNAVASSSGFITGAIAFGDAFAASAGTLTAAWAGGTGSESYTNGFFNWAVAQGTNASAVAGRQNSDFANFAFNFGNAVEPWLGGENDELGTSNVDASYGSFNLAANLGGNANAVEGTRKDLRVWAGGLEGEENFGSAALNLFGNRNDVQAFGSGVAAIAVGNPFGFPNGSDSIVRVGDFVEGISGGSLSLAFNIQPPFITEECDTGQCGNTVTVGNGYLSIAGAVGLVNRIVEQVGPGIRINTPFNPPQTVTNELAAEGTSTTSPKALAPKSTSDGIKGNKQRSFVRSSLDFSGGAKAAADRSDSTSKATDQGSSAPKSLKSRINETKKKVSDAVSKVTGKKSPKTDADDGGSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTG4</accession>
    <name>A0A132PTG4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844738.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25610">
        <property type="protein sequence ID" value="KWX25610"/>
        <property type="gene ID" value="AFM11_05095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2900"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="544" mass="58104" checksum="98A20924B537C78A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTI9</accession>
    <name>A0A132PTI9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aspA</name>
        <name evidence="2" type="synonym">fumC</name>
        <name evidence="5" type="ORF">AFM11_04935</name>
        <name evidence="6" type="ORF">AWC31_20215</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844682.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20215"/>
    <dbReference type="EnsemblBacteria" id="KWX25584">
        <property type="protein sequence ID" value="KWX25584"/>
        <property type="gene ID" value="AFM11_04935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16383">
        <property type="protein sequence ID" value="ORX16383"/>
        <property type="gene ID" value="AWC31_20215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2868"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="22"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="412"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="328"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX16383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="474" mass="50134" checksum="CD52186217C8B145" modified="2016-06-08" version="1">MSDKAVDASGEGEYRIEHDTMGEVRVPVNALWRAQTQRAVENFPISFRGLERTQIRALGLLKAACAQVNKDLGLLAPEKADAIIAAAGEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAARNGVTVHPNDDVNMSQSSNDTFPTATHIAATEAAVRHLIPALEVLHESLAAKARQWRTVVKSGRTHLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGELAIGGTAVGTGLNAPDGFGAKVVEVLVNQTGLAELRTAVDSFEAQAARDGLVEASGALRTIAVSLTKIANDVRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVACQVVGNDAAIAMGGASGAFELNVYIPMMARNLLESFTLLSNVSKLFAARCIDGLVANEEHLRELAESSPSIVTPLNSAIGYEEAAKVAKQALKEKKTIRQTVIDRGLIGDKLSEAELDKRLDVLAMAKVKDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTK7</accession>
    <name>A0A132PTK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21390"/>
    <dbReference type="EnsemblBacteria" id="KWX25679">
        <property type="protein sequence ID" value="KWX25679"/>
        <property type="gene ID" value="AFM11_03775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2631"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="131" mass="14477" checksum="EF85ECCC99998DA4" modified="2016-06-08" version="1">MFASGDLDALDDVVAPGAAFHDTQDPFGSQRGPEHMRNLIQMYRNAFSNMRFDVKLQISEGDYVCTLLEAQGDNTGELMGRPATGRHSRIQITQTDRIVDGKIEESWVTWDTLGMLQQLGLVPTGPQAAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTN4</accession>
    <name>A0A132PTN4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_03580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844865.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21575"/>
    <dbReference type="EnsemblBacteria" id="KWX25673">
        <property type="protein sequence ID" value="KWX25673"/>
        <property type="gene ID" value="AFM11_03580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2591"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="284" mass="30486" checksum="7CEFDFA174341BE1" modified="2016-06-08" version="1">MVTLAPEVTTAPKPELIEVVSGHGRKGLWSRIPRPVRRLLGPVLILAAWAIGSATALLDPDLFPPPSEVAITAWRLLVDGQLATHVGASATRVLTGTVLGIVIGVLLAVVAGLTRTGEDLLDWTMQILKAVPNFALTPLLIIWMGIGEGPKIVLITTGVAIAIYINTYSGIRGVDRQLVEMAQTLEAPRRTLITQVILPGAMPSFLVGLRLGLSSAWLSLIFAEMINTTEGIGFLMSRAQTNLQFDVSLLVIVIYAVAGLLSYTLVRVLERLLLSWRNGFDGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTY2</accession>
    <name>A0A132PTY2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842190.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33455"/>
    <dbReference type="EnsemblBacteria" id="KWX25780">
        <property type="protein sequence ID" value="KWX25780"/>
        <property type="gene ID" value="AFM11_00340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.69"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="237" mass="25480" checksum="319F1CBE65B3E26B" modified="2016-06-08" version="1">MTAPDDRLPRALRELWQQDTAPRHARGLTREAIVAAAIDLADADGLGALSMARLAERLGCGTMSLYRHVASKDELVMFMLSAGPGPPPPSSDHANWRDALENWAFGLWEVYHRHPWILPAASMGPPVDPGQLAWLDAGLAALASTGLSERDKLAAVMAVLHYVRGAAAIDIEAGQTDPGLFPFVVSTLLDRDRFPALAAAVRAGAFGDDDDRVADFRSGLNQLLDGVASRIPDPRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU02</accession>
    <name>A0A132PU02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842290.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33650"/>
    <dbReference type="EnsemblBacteria" id="KWX25818">
        <property type="protein sequence ID" value="KWX25818"/>
        <property type="gene ID" value="AFM11_00535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.110"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="226" mass="25835" checksum="359360E6F7682491" modified="2016-06-08" version="1">MSLPALEDITTHRGTADPIDGLIRIETSPKAKATPIIMEMMRSVYPHDQVFGEYCTVNDYIDCPPDELYDYLSDTRCLEEWTYSLRGFSPTEEPGLWLAHDRLGAGHGGPGSEIYTRTVANRDAMTVDYHCAWDQGKHLWMIYLMRVVDAQVVFDKPGSVVLWTNCHHPFYDHNPYPETAPPGRPVWVGDFWDMFGPGHLLELKNLKAIAEYRHRNGLPLTPAWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUG9</accession>
    <name>A0A132PUG9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetolactate synthase</fullName>
            <ecNumber evidence="5">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_00530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842287.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33645"/>
    <dbReference type="EnsemblBacteria" id="KWX25817">
        <property type="protein sequence ID" value="KWX25817"/>
        <property type="gene ID" value="AFM11_00530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.109"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_N" evidence="13">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="11">
        <location>
            <begin position="201"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="12">
        <location>
            <begin position="389"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX25817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="577" mass="59830" checksum="7585C91F9668236F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUH1</accession>
    <name>A0A132PUH1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_01415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842764.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34385"/>
    <dbReference type="EnsemblBacteria" id="KWX25963">
        <property type="protein sequence ID" value="KWX25963"/>
        <property type="gene ID" value="AFM11_01415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.290"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453351" evidence="4">
        <location>
            <begin position="20"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="5">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="525" mass="56193" checksum="487432836D09F9CE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUM3</accession>
    <name>A0A132PUM3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid APC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_00105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842061.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33215"/>
    <dbReference type="EnsemblBacteria" id="KWX25742">
        <property type="protein sequence ID" value="KWX25742"/>
        <property type="gene ID" value="AFM11_00105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.22"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004754">
        <property type="entry name" value="Amino_acid_antiprt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00905">
        <property type="entry name" value="2A0302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="506" mass="53913" checksum="0C672653CED95432" modified="2016-06-08" version="1">MTATEEQTEKADGKVSLPTLTAMVIGSMIGSGVFLLPRRFGAESGVAGALIAWTIAGTGMLMLAFVFQRLANRKPDLDAGVYAYGKAGFGDYVGFNSAFGFWASACAGNTSYWVLIMATASALFPALGSGDTVLAVLIASVGVWLFCFLILRGVKEAAIINRIATFAKVVPILVFIVIAVIAFQADVFTANFWGGDGNYSWNSLFEQAKGTMLITVFVFMGIEGASVYSRFARKREHVGRATVTGFLSVLAVFMLVTLCSYGVMPQEELGQVDDPPMAAVLESVVGPWGSVFIRIGVLLSVLGAYLAWTLMAAEILYLPAKNDDMPKFLTRTNSQGAPVTALIMATGLVQLLLILVLFTANALDFMLDLTAALALVPYLLAAAYALKLTITRETYDDRRSLVPDMIVAAVATAYTLFLLYAAGLDHLLLSCLLYAPGAVLYVIARRERGLRIFRPAEALLFGAIVIGAIAAVVSLATGAMHLDLPNPVEPTGLVHLPDPAETTGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUR7</accession>
    <name>A0A132PUR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843209.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35110"/>
    <dbReference type="EnsemblBacteria" id="KWX26099">
        <property type="protein sequence ID" value="KWX26099"/>
        <property type="gene ID" value="AFM11_02330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.477"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="454" mass="51378" checksum="571F262BF554D4F3" modified="2016-06-08" version="1">MTVLDERHRYPKLPHPPRRIPLLGDVFGFDADSPSQSAAELARLGAVFEFTFLGARYVVAAGADAVMDLNDENRFCKHVGPDIEALRIIGGDGLFTAYNDEPNWLKAHQLLMPAFSQAAMRRYHAVMFDVAGELTDRWDTSDTVDVSADTTRVTLETIGRCAAGYSFGCFESDEIHPFVEHMVSALKGADRVGVLRETFLPGFVARIFERRVRRDAAYLHDLADDIVAERRKAGPGRHGDLLDIMLGSDLDAANIRYQLINFLIAGHETTSGALSFALFFLSRHPEVFARARAEVDQVWGDEERPEFEKIAKLRYIRRVLDESLRLQPTVPGYYRAAREDTVLAGIHPMRKGDWALALTSTLHRDPRWGADPEGFDPDRFAPERVRARPGGLYKPFGTGERSCIGRQFALHETVLLLAVLIRRYDFEAEPDYRLQIQERLTMMPFGFRLGLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUS9</accession>
    <name>A0A132PUS9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_02340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843215.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26101">
        <property type="protein sequence ID" value="KWX26101"/>
        <property type="gene ID" value="AFM11_02340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.480"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX26101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="204" mass="23105" checksum="C9154FD4F1226288" modified="2016-06-08" version="1">MTAQLTEDIRRTAILDAAAQLIAERGYHSVRISDIAAVVGTSTGAVHYYFPGKSDVLTAALRYALDRAFERQSDELKKIDNAHERLLKLIDMQLPRVGPLRDEWSIWMQFWAEATIRPELRPIHNTYYARWHETVGRIVRRGQRQGIFRTDVDPETVAHRLTALTDGVAIQVLTGAPNMTVSAMKEILAQFVQDELIPRNVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUW6</accession>
    <name>A0A132PUW6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_00555</name>
        <name evidence="4" type="ORF">AWC31_33670</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842303.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25822">
        <property type="protein sequence ID" value="KWX25822"/>
        <property type="gene ID" value="AFM11_00555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11636">
        <property type="protein sequence ID" value="ORX11636"/>
        <property type="gene ID" value="AWC31_33670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.114"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453653" evidence="2">
        <location>
            <begin position="31"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="142" mass="14384" checksum="85A9EE4A9EDE0AE8" modified="2016-06-08" version="1">MYAKRLGLVLAAAAIAVAACTTTTSGVATAPDDVTPFTTSKKPTKSPTRTRTPTATAAPGTGLPPEAFAEVRAAGIEGSDSAISDQVSLACIMAAGSFNDSKQDVVDVLIQMGSKLPPEALLVIVDVAVKYECPEYAGKLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVY4</accession>
    <name>A0A132PVY4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fcl</name>
        <name evidence="4" type="ORF">AFM11_02905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843509.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26192">
        <property type="protein sequence ID" value="KWX26192"/>
        <property type="gene ID" value="AFM11_02905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.598"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="313" mass="34329" checksum="920803EBB4AD8E6B" modified="2016-06-08" version="1">MDIDSRIYVAGHRGMVGSAIHRRLLDEGYSNVVTRTHRDLPLDDPAAVERFFAAERPDFVVLAAAKVGGIVANSTQGADFIRENLKIQTNVIDAAYRYGARKLLFLGSSCIYPKHAEQPIVEEALLTGPLEQTNLPYAVAKIAGKTMCDAYRAQYGFDAFTVMPSNVYGVGDNFHPEHSHVVAGMMARFHAAKLAGADKVVVWGTGSPLRELIDADDLADACVFLLRSDFSGDMINVGSGEEISIRDLALLMKSIVSFDGDVEFDSARPDGTPRKIMDNTKLTALGWRPTHSIEAGLKKMYAWFLETEATRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAQ1</accession>
    <name>A0A132PAQ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_36050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000075">
        <property type="protein sequence ID" value="KWX19403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19403">
        <property type="protein sequence ID" value="KWX19403"/>
        <property type="gene ID" value="AFM11_36050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="82"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="201" mass="21158" checksum="511F620AD5DE7A42" modified="2016-06-08" version="1" fragment="single">LRPVPPGVVGELYVAGGGLAVGYVGRSGLTGSRFVACPFGASGVRMYRTGDLVRWGVDGQLVYVGRADEQVKVRGYRIELGEIQVALAALEGVEQAAVVAREDRPGDKRLVGYITGGADPVVVRGLLGERLPGYMVPAAVVVVESLPLTVNGKLDVRALPAPEYRDGDGYRGPSNATEEILAGIYAQVLGLDQVSVDDSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAS4</accession>
    <name>A0A132PAS4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000054">
        <property type="protein sequence ID" value="KWX19429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067860032.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19429">
        <property type="protein sequence ID" value="KWX19429"/>
        <property type="gene ID" value="AFM11_35915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6260"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="280" mass="29848" checksum="0E9BA3400B083A02" modified="2016-06-08" version="1">MNVWFITGASRGFGLEIAREALSRGDSVVATARNPQAVYDAIPDAGDRLLAVALDVHDAAQIDAAVQAAVEKFGRIDVLVNNAGRGLLGAVEEATDEEVRAVYDVNVFGLLAVTRAVLPTLRAQRSGTIINLSSVGGFVSGPGWGVYSSTKFAVEGLSEAMTHELAPLGIKVVAIEPGPFRTNFLDGSSLAIAANEIADYAETSGVTRKWADDTNYAQDGDPLKAAKIIVDLPSYDTLPERIQLGRNAFDRIAAKLERTARDQEAWREIALSADYETAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAT6</accession>
    <name>A0A132PAT6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000051">
        <property type="protein sequence ID" value="KWX19445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859981.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19445">
        <property type="protein sequence ID" value="KWX19445"/>
        <property type="gene ID" value="AFM11_35825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6244"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046179">
        <property type="entry name" value="DUF6188"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19686">
        <property type="entry name" value="DUF6188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="144" mass="15858" checksum="DA49459578C6EE91" modified="2016-06-08" version="1">MFTQWIEDCVVQRVSLRDGLVLDLDGYSELVISRPLRLTLPPVGDFPAEQVLIDPTRVAVHERPLLDLAGAVCTHARYGDDGALHLGFSRGHRIDVEADAHATAWELYGKRHGYMACLPRGRVRVVRHDIPDADDTDAGVGAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAV5</accession>
    <name>A0A132PAV5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000052">
        <property type="protein sequence ID" value="KWX19434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067860000.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22480"/>
    <dbReference type="EnsemblBacteria" id="KWX19434">
        <property type="protein sequence ID" value="KWX19434"/>
        <property type="gene ID" value="AFM11_35860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6251"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="27410" checksum="5BDA613FD1E3D711" modified="2016-06-08" version="1">MRRGLDKVVDSAARAVADIPSGASLAVGGFGLCGIPSVLIGALLEHGADDLEVVSNNCGVDDWGLGILLAAGRIRRTVASYVGENKEFARQYLSGELEVELTPQGTLAERMRAGGSGIPAFYTATGVGTQIADGGLPWRYAPDGTVAVASPAKETRVFDGREYILEESIACDYALVRAWKGDRYGNLVYRDAARNFNPLAAMCGHITIAEVEELVEPGEIDPNDIHTPGVFVHRVVALTPEQAADKRIEKRTVRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAW0</accession>
    <name>A0A132PAW0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diadenosine tetraphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_35720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000047">
        <property type="protein sequence ID" value="KWX19463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859921.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12680"/>
    <dbReference type="EnsemblBacteria" id="KWX19463">
        <property type="protein sequence ID" value="KWX19463"/>
        <property type="gene ID" value="AFM11_35720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5880"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="5">
        <location>
            <begin position="51"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="189" mass="20890" checksum="96F70E5C9777FFEA" modified="2016-06-08" version="1">MTEDERTIVDRGVGDPDHLQRLWTPHRMSYIAEAPMKKRGEGGGSASSSQPFTDIPEMSDEDGLMVARGEQVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDAESAELMAFTQKAIRVIKAVSRPHGFNVGLNLGTSAGGSLAEHLHMHVVPRWGGDANFITIIGGSKVIPQLLRETRELLATEWARQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB57</accession>
    <name>A0A132PB57_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859659.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19571">
        <property type="protein sequence ID" value="KWX19571"/>
        <property type="gene ID" value="AFM11_35115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5751"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="60" mass="5812" checksum="846066079BD7613C" modified="2016-06-08" version="1">MSVIGSVAGQALGAAATAPPSLALPLLAAMVCAQAILIGLAGLRAAATQFDPKSVQHKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBB4</accession>
    <name>A0A132PBB4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859472.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10930"/>
    <dbReference type="EnsemblBacteria" id="KWX19625">
        <property type="protein sequence ID" value="KWX19625"/>
        <property type="gene ID" value="AFM11_34785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5306"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="122"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="209" mass="21998" checksum="74E6A89E8AF0B9C0" modified="2016-06-08" version="1">MAGFTHVEHLSAADVQRLRSVYEPLAESVRELIDATIRSEVDAAEVAAAIAEIDAATARLRAKQIDGPFGVRYTSDGARMPWGNPAIGIKNPISPPLVIVKDGSGTISTDFRLGAAYEGPPGHVHGGIVAMVLDHVLGEVAASDPTSPRFTGTLTIRYLRATPLGDLHAEGRITRTDGIKAFAAGHVSDAEGITAEAEGVFILPKWARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBB7</accession>
    <name>A0A132PBB7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859611.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19606">
        <property type="protein sequence ID" value="KWX19606"/>
        <property type="gene ID" value="AFM11_35010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5731"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="12"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="289"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="472"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="544" mass="59466" checksum="4E8E3189004DCCB7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBX9</accession>
    <name>A0A132PBX9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33795</name>
        <name evidence="4" type="ORF">AWC31_07960</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858885.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07960"/>
    <dbReference type="EnsemblBacteria" id="KWX19830">
        <property type="protein sequence ID" value="KWX19830"/>
        <property type="gene ID" value="AFM11_33795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10105">
        <property type="protein sequence ID" value="ORX10105"/>
        <property type="gene ID" value="AWC31_07960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5096"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX10105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="175" mass="18096" checksum="34FAD8E00A7565DD" modified="2016-06-08" version="1">MSRPDPYANLPQLPSFTLTSESVTDGQPLGNDQVSGIMGAGGSDISPQLSWSGFPAETKSFAVTVYDPDAPTASGFWHWAVADLPATVTELPAGAGDGSPLPGGAVTLANDAGQKRFIGAAPPAGHGPHRYYIAVHALDVDKLDLPDGATPAYLGFNLFGHAIARAVIHGTYEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC59</accession>
    <name>A0A132PC59_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858771.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02175"/>
    <dbReference type="EnsemblBacteria" id="KWX19921">
        <property type="protein sequence ID" value="KWX19921"/>
        <property type="gene ID" value="AFM11_33575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5048"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="127" mass="14338" checksum="55017491E1B90C3F" modified="2016-06-08" version="1">MAITFNHTIVAAKDRQESAVFFTELFGLPSPREFGPFLAVTLNHGVTLDYAQASPDEEIRPQHYAFLVSEDEFDAIYGRVRDWGLQHWADPRGTRPGEINHNDGGRGVYFQDPSGHYLEIITRPYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCA2</accession>
    <name>A0A132PCA2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4173 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858558.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17015"/>
    <dbReference type="EnsemblBacteria" id="KWX19953">
        <property type="protein sequence ID" value="KWX19953"/>
        <property type="gene ID" value="AFM11_33210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4974"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025231">
        <property type="entry name" value="DUF4173"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13777">
        <property type="entry name" value="DUF4173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4173" evidence="2">
        <location>
            <begin position="276"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="518" mass="56011" checksum="B601B256AD5BE81A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCQ5</accession>
    <name>A0A132PCQ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20113">
        <property type="protein sequence ID" value="KWX20113"/>
        <property type="gene ID" value="AFM11_32320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4792"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="165" mass="18255" checksum="99DF0D5F270EC944" modified="2016-06-08" version="1">MQMCWVVPDLQNAIDSWVSNAGVGPFFWFDGVDFTDGRHRGTPADFPKVQAAIAYAGEVQIELVCQDNDDPGVFRDLFPHGTFGLHHMALYCHDYEAERDSYIKAGAQLAFEGKLDGIRTSWVDTSPTLGFMVELLEPSPQRHVGFAAMRAAAAKWDGSDPVVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCV0</accession>
    <name>A0A132PCV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_34150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859092.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02600"/>
    <dbReference type="EnsemblBacteria" id="KWX19792">
        <property type="protein sequence ID" value="KWX19792"/>
        <property type="gene ID" value="AFM11_34150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5167"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="429"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="521" mass="56608" checksum="1E2DB5A50A06A293" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD51</accession>
    <name>A0A132PD51_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell filamentation protein Fic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857542.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26090"/>
    <dbReference type="EnsemblBacteria" id="KWX20263">
        <property type="protein sequence ID" value="KWX20263"/>
        <property type="gene ID" value="AFM11_31510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4207"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041535">
        <property type="entry name" value="VbhA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18495">
        <property type="entry name" value="VbhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="109"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="260" mass="29414" checksum="16282F0E9B4545BE" modified="2016-06-08" version="1">MVSTRERHALAQTLAAERLEGWRPTSAEVSDLTELATGAVTFGQYLGRHLPHEIHRYRRPLFARRRPYLIPGTTVLRNNFGVHDAPTLTRLEFVATAGRIVQVHLRPEDHDLDARRLHQHVFGDVYAWAGEPRIVELRRGDSTFGSCVRIPRALRALQSDIESLAGAAAALDGGELAYRLARIYAVYNQIHPFREGNGRTGTLLLHLITVRAGRRLCLTDVSRADWITASRDSLPFRRDGPPDPRPFIPILRNCLRDREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDK4</accession>
    <name>A0A132PDK4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_31180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857337.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26890"/>
    <dbReference type="EnsemblBacteria" id="KWX20409">
        <property type="protein sequence ID" value="KWX20409"/>
        <property type="gene ID" value="AFM11_31180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4140"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="8">
        <location>
            <begin position="4"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="318" mass="31882" checksum="342D5BDFB1A23FDC" modified="2016-06-08" version="1">MAEVLVLVEHADGALKKVSAELLTAARVLGEPAAVVVGKPGSAASLTDGLKAAGAAKIYVAESDDVENYLITPVVDVLAGLAESAAPAGVLIAASADGKEIAGRLAARIGSGLLVDVVDVKEGAVGVHSIFGGAFTVEAQVTSDTPVITVRPGSVEAAPADGAGEVVNVEVPAQAETATKITKREPAVAGDRPELTEATVVVAGGRGVGSADNFSVVEELADSLGGAVGASRAAVDSGYYPGQFQVGQTGKTVSPQLYIALGISGAIQHRAGMQTSKTIIAVNKDEEAPIFEIADLGIVGDLFKVTPQLTEAVKARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDR2</accession>
    <name>A0A132PDR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856847.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20468">
        <property type="protein sequence ID" value="KWX20468"/>
        <property type="gene ID" value="AFM11_30295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3956"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="336" mass="36120" checksum="C3E509DDEB5EAB03" modified="2016-06-08" version="1">MAVATGARLSTTSEGLWLTAALSGISRLPRALKVRPTDGIEGADLGSHPGIAVLKDAGVYNGSVVDADVAEWVTVLGRPDIEVTIEVNVPAVASDRLLGPPPVFTTTAELAAIRNGGDAAIQAYEELLEWRKQQPTQRIATLCRRDRYWVSAARVWHPADDEVPGDESPQPPSSELDEIVVTPLGQKPVGTAVLELIGKIGQAEFRGLSANSRVLDSIVSQWQYDPDTNLVGQLVDELAISPEQARIIEAVGDRSTARATIGACEYHFDGPRTAQKAILVADTIYGRVLVSSDTGFDDQDWTMLTPGTEARIDAALGEVLTSLPCGVEWPHYRRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDT1</accession>
    <name>A0A132PDT1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkyl hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_30455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20491">
        <property type="protein sequence ID" value="KWX20491"/>
        <property type="gene ID" value="AFM11_30455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3990"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453023" evidence="4">
        <location>
            <begin position="32"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="196" mass="21519" checksum="41C8F61DEDA737D7" modified="2016-06-08" version="1">MWHVKLGRVVVVTLLGALAVVSCSTGSDAVAQGGTFEFVSPGGKTDLFYDPPQVRGTVRGLTGLDLREDRPVRLSDFADKVVVINVWGSWCGPCRTETPELEKVFEETEPLGVAFLGIDVRDNRTAAIDFVTDRKVRYPSIFDPSMRSLIALGKGYPTSVVPTTLVLDRQHRVAAVFLRALLAEDLRPVVQRIAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE89</accession>
    <name>A0A132PE89_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856720.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25165"/>
    <dbReference type="EnsemblBacteria" id="KWX20645">
        <property type="protein sequence ID" value="KWX20645"/>
        <property type="gene ID" value="AFM11_29825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3857"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="307" mass="33017" checksum="F47F50FAB0BA18D4" modified="2016-06-08" version="1">MSLPQLPSGRTVEVRAVDGVKLHAQVFGPEDGYPIVLAHGITCAIEVWAHQIADLSGDYRVIAYDHRGHGRSETPRSRNRYSLNHLAADLDAVLDATLKPGEHAVIAGHSMGGIAITSWSQRYPNRVRSCADAVALINTSTGDLLRDVQLAQVPARLTATRIRTAGTVLRTFGSTRMPKMAEGPNKRFVAQLAVGRDAEPWVADFVYQLFAATPPAGRGAWTRVLVDNLGPKHISLRNLTVPTLVIGSAKDRLLPINASRRIAADAPNLAGFVELGGGHCAILERPDDVNAQLRSLAESVTAAQRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEI8</accession>
    <name>A0A132PEI8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_29510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856687.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24850"/>
    <dbReference type="EnsemblBacteria" id="KWX20637">
        <property type="protein sequence ID" value="KWX20637"/>
        <property type="gene ID" value="AFM11_29510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3793"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1128" mass="120430" checksum="B46B3DABD7369E2A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEJ1</accession>
    <name>A0A132PEJ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20750">
        <property type="protein sequence ID" value="KWX20750"/>
        <property type="gene ID" value="AFM11_29325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3753"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="187" mass="20431" checksum="D149367D7654FC70" modified="2016-06-08" version="1">MSVSTAGAAGTLRVQVWRKLRSLGALYLQQSVCLLPAHAHVVREVRRLADRIHHHGGTARVLPMSFVDPADEQAVIDELNAARDGEYAEVLERLPALRQELADERARGRLTYAEVEESEADLDRFRSWLAKIAARDYFTAPGGHAARAAVDAAAAELAAFEDAALQAETSAQTDARTSQRLHVAHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF56</accession>
    <name>A0A132PF56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855959.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10250"/>
    <dbReference type="EnsemblBacteria" id="KWX20976">
        <property type="protein sequence ID" value="KWX20976"/>
        <property type="gene ID" value="AFM11_27715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3417"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453042" evidence="2">
        <location>
            <begin position="37"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="197" mass="19052" checksum="7F17E8E980E68540" modified="2016-06-08" version="1">MAERQRATLSLSAAKFAIAGVTVAGAVLAAAVPAAAEPAPPVPPPSDPAAAAPGQPVVLPPDGAVPPPAPPPAGPPPVPEMANPAYGSGQYGSGPLGTLRDLWHQAQNPYDLQGPTGPAAPPPPGAGPPPPLPPGYVSMNAPGSETPVTAPDPNAGPGAEGPPLPPGYYPLDGPPPPGYEYNTPGAPAPAPPPPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFU0</accession>
    <name>A0A132PFU0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetic acid degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854919.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22880"/>
    <dbReference type="EnsemblBacteria" id="KWX21195">
        <property type="protein sequence ID" value="KWX21195"/>
        <property type="gene ID" value="AFM11_26435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3156"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="183"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="267" mass="27676" checksum="5BFB70EDEF3E74E8" modified="2016-06-08" version="1">MHYPLSTPLGRMGVETQIEGPDRCVASIPASGLLNPFTGAPTLAPVAMLIDHVGGLVNHHRRGPDEWTVSSELAVEFAPNAVELVGAAPKLPVVAAGRPFGPTGAAPLALCELTHAGQLLATATVRSFHITAPGHLVEWPTDSADAALPTTLTERMAVEVAESGGTTKVLRQLSDPVINNSLGIVHGGMSAAALELVASAAVNEGQEASPMRTGSLRINFLRQFRGGDESRYEGKAVRVGRSTAVADASAVGDDGKVALLARLTAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG25</accession>
    <name>A0A132PG25_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_25545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854408.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24735"/>
    <dbReference type="EnsemblBacteria" id="KWX21296">
        <property type="protein sequence ID" value="KWX21296"/>
        <property type="gene ID" value="AFM11_25545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2972"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="2">
        <location>
            <begin position="185"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="340" mass="36372" checksum="DEA98097A7327235" modified="2016-06-08" version="1">MSTHVDAELVNMMSAVFAAHRERYEPGHGLDELWGQLSELGLVRLTGSEESGGSGAGWPEAAELLRAAAWHGVSAPLAEHDLLACWLLETAVLPVDDSRRTTCVLDDGSARGVPWASAAERLVIVWHDGASYRVDDVPADSVSINSGENGAGEPRDEVRVDTAGLTGTPVPDNVIRQWHLRAALVRAIQVCAVLDRILESSVAHAIERTQFGRPLAKFQAVQNLVADIAAEAALARAATDGALAEALRSDWGSPNLEFLVAVARSCAGHAASVVVRNAHQVHGAIGTTREHRLHEFTKPALSWRSEYGSVQHWDDKLTDFATAAGAEGLWALTTATADRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGE3</accession>
    <name>A0A132PGE3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854709.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21396">
        <property type="protein sequence ID" value="KWX21396"/>
        <property type="gene ID" value="AFM11_25555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2974"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="410" mass="44242" checksum="E243F5EBF0A4F908" modified="2016-06-08" version="1">MTPGALAGLRVIDLTTVIMGPFATATLADLGAEVIKVENLDGDMSRDIGARRHEGMGALTMNLQRNKRSIAVDLGSAEGRRILDDLVRDADVLVTNLRPRSRDKLGITYERMSALNPGLILCTAQAYGSQTAYRDYPAYDDIVQAASGAAKLSELVDGAPRYAPYVIADKVVALYIVIAVLAAAMEKKVTGLGQAVDVPMVDAMIGFNLVEHLGGHTFAPAEADFGWTRVLTPERVPHRTADGWICIMPYSAQNWRDFFTAAGRPDLVDHPRYATVDDRHRHMGELLTAVREAAPSKTTGEWLKICEAHGIPASDLLDLADAHDDDYVTGQELLAKHTHPTEGDYYATRTPFAMSRTPVRLRRHAPLLGQDTAEILGGLGYPEAEIAALLDAGVVKATSTVASTATQGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGE4</accession>
    <name>A0A132PGE4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_26150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854772.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35745"/>
    <dbReference type="EnsemblBacteria" id="KWX21419">
        <property type="protein sequence ID" value="KWX21419"/>
        <property type="gene ID" value="AFM11_26150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3095"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017523">
        <property type="entry name" value="CHP03089"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03089">
        <property type="entry name" value="TIGR03089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="235" mass="24573" checksum="F2FEF4676D77BD52" modified="2016-06-08" version="1">MTTTVSAAVLDPLLASDPAGPRITYYDDATGERIELSAVTLANWAAKTANLLRDEMGAGPGTRVAVLLPAHWQTAAVLFGVWWIGAEVVLSGAADIALCTRDRLDEADDAVSGGEVAVLSLDPFGKPAADLPIGVTDYATSVRVHGDQIVPERQPGPALDGRSVADVLSAARTSAAAQEFTDADRVLSTAAWDDPDALVANLLAIFAVGASLVQVANPESDAQERRRQMEKVTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGG1</accession>
    <name>A0A132PGG1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylglycinamide formyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853956.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26945"/>
    <dbReference type="EnsemblBacteria" id="KWX21421">
        <property type="protein sequence ID" value="KWX21421"/>
        <property type="gene ID" value="AFM11_24690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2299"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="133" mass="15143" checksum="E1EDA6A2CE4C8C99" modified="2016-06-08" version="1">MPHPIMFSDDDPGLPELRAITLAFPEAFEKVSWGRPVFCAPKMFAMYGGNAKTETPGEMVAYPHSVLVKVDDSDRKALEQDRRFYFPAYMGPFGWLGLDFTAAKVDWDEVRELVDASFRLVAPKKLIKQLDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGI9</accession>
    <name>A0A132PGI9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Acetolactate synthase</fullName>
            <ecNumber evidence="5 10">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_24810</name>
        <name evidence="16" type="ORF">AWC31_27065</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="5 10"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854015.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27065"/>
    <dbReference type="EnsemblBacteria" id="KWX21441">
        <property type="protein sequence ID" value="KWX21441"/>
        <property type="gene ID" value="AFM11_24810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14820">
        <property type="protein sequence ID" value="ORX14820"/>
        <property type="gene ID" value="AWC31_27065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2323"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="8 10 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="14">
        <location>
            <begin position="43"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="12">
        <location>
            <begin position="232"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="13">
        <location>
            <begin position="431"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX21441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX14820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="624" mass="66341" checksum="2B436976702CCDEE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGK0</accession>
    <name>A0A132PGK0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27525</name>
        <name evidence="4" type="ORF">AWC31_07460</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855595.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07460"/>
    <dbReference type="EnsemblBacteria" id="KWX21122">
        <property type="protein sequence ID" value="KWX21122"/>
        <property type="gene ID" value="AFM11_27525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10336">
        <property type="protein sequence ID" value="ORX10336"/>
        <property type="gene ID" value="AWC31_07460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3379"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX10336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="96" mass="10908" checksum="70C6A4396477DAAC" modified="2016-06-08" version="1">MSLFFQILGFALFIFWLLLIARVVVEFIRSFSRDWHPKGFTVVVLELIMTVTDPPVKLLRRLIPQLTIGAVRFDLSIMVLLLVAFIGMQLAFGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGN9</accession>
    <name>A0A132PGN9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ORF">AFM11_25100</name>
        <name evidence="9" type="ORF">AWC31_27420</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854153.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27420"/>
    <dbReference type="EnsemblBacteria" id="KWX21491">
        <property type="protein sequence ID" value="KWX21491"/>
        <property type="gene ID" value="AFM11_25100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14880">
        <property type="protein sequence ID" value="ORX14880"/>
        <property type="gene ID" value="AWC31_27420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2381"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX14880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="158" mass="16971" checksum="C01CADCC9387C0CD" modified="2016-06-08" version="1">MSGAVCPGSFDPVTLGHIDIFERAAAQFDEVVVAVLVNPNKKGMFDLDERMAMIVESTAHLPNLRVESGQGLVVDFVKSRGLTAIVKGLRTGTDFEYELQMAQMNKHVAGVDTFFVATTPQYSFVSSSLAKEVASLGGDVSALLPEPVNVRLRAKLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHG1</accession>
    <name>A0A132PHG1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21647">
        <property type="protein sequence ID" value="KWX21647"/>
        <property type="gene ID" value="AFM11_24310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2221"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="156" mass="16678" checksum="BA1230A326814FC7" modified="2016-06-08" version="1">MCGEHMKMIIMSDMPARSLTLLSADLDQLLAEVGAGTLLLTVPVLDDAIQVGIGGDYPTGTIAVTTTACGVRIRHLDGRPMQVHIVRDWQDADAPGIRSTLFGEPVHELPLERHGRSWVIGTGVPVGRAEDLATFVNTVARFAVAKQRKTGQVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHG3</accession>
    <name>A0A132PHG3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853098.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28010"/>
    <dbReference type="EnsemblBacteria" id="KWX21775">
        <property type="protein sequence ID" value="KWX21775"/>
        <property type="gene ID" value="AFM11_23240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2001"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="144" mass="16044" checksum="0D003275867977FF" modified="2016-06-08" version="1">MDEAPNSAVMMFIAYRAAENRILEVVHRAGFTDLTLAQCRIAQRLSPQGIRLTDLAEQAQVTKQTAGALVDELERAGYVVRQPDPTDARARLVMLAERGTTVCRVAAAEVDAIEAEWREHLGAKAYRDLRRALVALREITDPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHH5</accession>
    <name>A0A132PHH5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Filamentation induced by cAMP protein fic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_23260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853103.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21776">
        <property type="protein sequence ID" value="KWX21776"/>
        <property type="gene ID" value="AFM11_23260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2005"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026287">
        <property type="entry name" value="SoFic-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038925">
        <property type="entry name" value="AMP-prot_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="137"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="229"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="230"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038925-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="391" mass="43170" checksum="F65D5F76D47E6CDA" modified="2016-06-08" version="1">MQVARFEKSPVGKLVPIEGMDHLLGERYSHFAFVPDPLPADIQLAARSVKVLEDAARALGRLDSKIQLLPNPNLLVRPSLRKEAVSTTALEGTFAPLSEALGADYVDEQRQSAEIREVMNYVRAATQSMHMLNELPICLKMLSTLQATLVRGTRGDAYDAGQLRQRQVCIGQQGRGVEASRFVPPPNGDILVAGMSDWEKWVNASDDLPLLVKVALAHYQFETLHPFSDGNGRLGRLIITLQLMQAGALKYPILNLSPWLEPRREQYIDHLLEVSATGNFEPWINFFCQAVVARADAATETIAAMLDIREEFADQLRAVGASGMVLQLASDLIGFPYISAGEAADLYGVAYPTANNAIAKLAKLGILEEITGREYRRVFRCPRVYEIIARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHR0</accession>
    <name>A0A132PHR0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24505</name>
        <name evidence="3" type="ORF">AWC31_23615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853936.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23615"/>
    <dbReference type="EnsemblBacteria" id="KWX21737">
        <property type="protein sequence ID" value="KWX21737"/>
        <property type="gene ID" value="AFM11_24505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15717">
        <property type="protein sequence ID" value="ORX15717"/>
        <property type="gene ID" value="AWC31_23615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2262"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="143" mass="15722" checksum="4E00B0C547D1AA70" modified="2016-06-08" version="1">MTVTSFDPRSLLAEARLGVLATIKSNGVPQLSPVTPFYDRNADVIYVSMTEGRAKTVNLRRDPRAALEVTSADGWAWATAEGAVTLTGPGTDPHGPEVQALVDYYRNAAGEHPDWDEYRSVMVSDRRVLMALAVERVYGEKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHX9</accession>
    <name>A0A132PHX9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_24065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853571.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21612">
        <property type="protein sequence ID" value="KWX21612"/>
        <property type="gene ID" value="AFM11_24065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2172"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="142" mass="15033" checksum="781A7D32C6D10B56" modified="2016-06-08" version="1">MQESSTRHVPAVGETAEMSRTIGADDIAMFTELSGDRNPIHYDEAAAKASRFGEIVVQGGVTSAILNAVVAEKLPGPGTVFLNVNWNFRAPVRPGDTITGRVEITAVRADKPITELVTTVTRDDGTLVLDGTAVCYTMDLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHY0</accession>
    <name>A0A132PHY0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_22555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852761.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08650"/>
    <dbReference type="EnsemblBacteria" id="KWX21946">
        <property type="protein sequence ID" value="KWX21946"/>
        <property type="gene ID" value="AFM11_22555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1861"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="27"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="466" mass="47233" checksum="36E1403CAC6F02A1" modified="2016-06-08" version="1">MTDTATTATNGATGTWRQLLGPRNLGASTVLAGGVLLYATNEFLTISLLPSAVADIGGQRFYAWVTAVYLVASVMAATTVHSVLIRMGPRLAYLSALTVFGAGSLGCALAPSMQILLTGRTVQGFAGGLLAGLGYAVINTALPNTLWTKASALVSAMWGVGTLVGPAAGGLFAQYGHWRWAFGVLVILTVAMAVLVPIALPGRGDETAAAPGIPVASLALLGSAAMAVSVAGIPHDARATAALLTLGIALVVAFVFVDRRAKAAVLPPSTFGAGPLKWIYLTLGVLMAATMVDMYVPLFGQRLAHLTPVVAGFFGAVLSVGWTVGEIASASVQNRRVIVRTVAIAPLVMAVGLTAGAILVRNGMPAWLVVLWALGLLVTGAGIGIAWPHLSAWAMSSVDDPAEGPAAAAAINTVQLICGAFGAGLAGVVVNLTDTGDASAARWLFGAFAVLATAGAIASFRSGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI02</accession>
    <name>A0A132PI02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853638.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21632">
        <property type="protein sequence ID" value="KWX21632"/>
        <property type="gene ID" value="AFM11_24205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2200"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="118" mass="13617" checksum="DC1038A4C4A75F7A" modified="2016-06-08" version="1">MAKYALNESAVEFARELIESRQYVLDSDWGEVQPRADAQNSYLENHDWDEYANWHLGLTEGANDETKARYAFVYGDFRRVHRTGLIACVYRASEWRHKAVELAAHDLLQLLDKAAGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIL3</accession>
    <name>A0A132PIL3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_23650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853300.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21842">
        <property type="protein sequence ID" value="KWX21842"/>
        <property type="gene ID" value="AFM11_23650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2086"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="750" mass="82926" checksum="00052978907C5D72" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIV5</accession>
    <name>A0A132PIV5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22276">
        <property type="protein sequence ID" value="KWX22276"/>
        <property type="gene ID" value="AFM11_20805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1499"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="97" mass="10662" checksum="5CBA42E2641BE648" modified="2016-06-08" version="1">MAPHRLQPFAVLRIAGRHDRGLVQRHPSGDRAQIRQPDPAQVGFAVRAPASVLVRLGQYALFLPPAQCRRCQPVEGGGLTDLYVRATSVFVHAEQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIX6</accession>
    <name>A0A132PIX6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cutinase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_20910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852120.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06330"/>
    <dbReference type="EnsemblBacteria" id="KWX22296">
        <property type="protein sequence ID" value="KWX22296"/>
        <property type="gene ID" value="AFM11_20910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1523"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007356433" description="Cutinase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="253" mass="24902" checksum="747A5B7A6B1E48CF" modified="2016-06-08" version="1">MSTVVTKVAKSTLFTVLAAAAIVVGTLAGPVATANAAADACADVEVVFARGTNEAPGVGATGQAFVDALTAQLPGKSVDVYAVNYPASLNFGQAVDGIVDASNRIQSIAASCPDTKIVLGGYSQGAAVAGYTTSSSVPAGYVLPAGLSGPMPAEVASHVAAVALFGTPDGWFLSLADRNAPPITIGAPYAAKTIQLCATGDPVCFPGGLDRGAHSSYKVNGMAVQAADFVARQLGGSAPSATLVQTAGEAGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIZ0</accession>
    <name>A0A132PIZ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852168.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06405"/>
    <dbReference type="EnsemblBacteria" id="KWX22320">
        <property type="protein sequence ID" value="KWX22320"/>
        <property type="gene ID" value="AFM11_21040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1554"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="507" mass="55851" checksum="0402FC1D944AEB9B" modified="2016-06-08" version="1">MSDSKLTEPVSDSASYQLGTSRPPLGVDDLPEPEEVFKVSRLGPAQIVKFVIGPSLIALGISVGSGEWLLGPQAVGAYGFVGIGWVITVSAILQTFYNVEVSRYVVATGEVPIVGWGRVPPGWKFWIPVSLIVFYFAFIFGGWAASAGQGLFALIAGRVHRPDELEYTRLLAIGLLFVVFLICVFARKISRALELSNWVIVGSLLAVLLVVDIAIVPPSVWWEGIRGLVTPAAPPPGITATTLGALAGFTALASGLNWYAMAHYRDKGYGMGHRVGYISGMRGDRRELLPVGVTFRDTPENASRWKRWYRLLLIDQWAVFFCGAMLGMLLPTILMAHIVATTGDAPTTSNVPTFTAEKLGEQYGSGMFYLMLVVGVLILFSTQLGIFEALVRNFTDAAHATSPRLRRLLEGDPRRFYYPFMLVVLVIIAGAIHLTTPVRLVQISANMSNLGALAFPFMLMYLNSKLPRPARPRWWHYVLLVLNFLFFGFFFVNFVYELISGTPLVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ42</accession>
    <name>A0A132PJ42_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phytase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_20845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852096.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06260"/>
    <dbReference type="EnsemblBacteria" id="KWX22284">
        <property type="protein sequence ID" value="KWX22284"/>
        <property type="gene ID" value="AFM11_20845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1508"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453115" evidence="1">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="2">
        <location>
            <begin position="45"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="350" mass="37217" checksum="4DB2E18D8D47FE77" modified="2016-06-08" version="1">MLRRTLLAVVLLLTGCNADAGAAPGFECLGQQRIASGATLDGTVIGGLSGISYDAGAGLYYIVSDDRSAKNPARFYTAQIALSDNGIERVDFVGTRPWLDSHGKPFAPLDAEARPPVVPPDPEGIAYDARRGRLYWTSEGERGDGGVQLDPWVRIAGLDGTYLGEFALPDALKTSAPDHGARQNRALEGLSLTPDGRYLWAAMEGPVYQDGALPDEQHGAITRITRYDVDTGTADREYTYPLDPVSAGPGGDNGLSDLVALDDGTFLVVERGYGTHVAVRVYRAGVTEGSGQLTKTLLADLTNTPGLTPLDNIEGITLGPKLSDGRQSVIMVSDDNFSPTQITQFLLFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ55</accession>
    <name>A0A132PJ55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal biosynthesis lyase PdxS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_05335</name>
        <name evidence="4" type="ORF">AFM11_19690</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22380">
        <property type="protein sequence ID" value="KWX22380"/>
        <property type="gene ID" value="AFM11_19690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24873">
        <property type="protein sequence ID" value="KWX24873"/>
        <property type="gene ID" value="AFM11_05335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1272"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiG" evidence="3">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="100" mass="10339" checksum="E0C2DBECE3C3D1BC" modified="2016-06-08" version="1" fragment="single">LVVEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSGNPAQRAAAIVKATTFYDDPDVLAKVSRGLGEAMVGINVEDIAQPHRLAERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ59</accession>
    <name>A0A132PJ59_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11075"/>
    <dbReference type="EnsemblBacteria" id="KWX22389">
        <property type="protein sequence ID" value="KWX22389"/>
        <property type="gene ID" value="AFM11_19735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1281"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453117" evidence="1">
        <location>
            <begin position="21"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="193" mass="19988" checksum="AA38844C3F0754A1" modified="2016-06-08" version="1">MKACMAIRTAVLVAATVTLAACTSGTVVNTGDTPQQTAPPTSAPMPQFGTANLVNAADFAAPVDGRTAYYFSTPSGRWNCAILPRDRAGCESADGLDSGIGITGAPDVIVDGEPTTPNAIVVDRDHDAAFVVLPQTQFSLDTAAVLPFGKVLAVAGFRCNVQEEHGVSCVRELTGKGFTFSGDGYTLQYTDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ69</accession>
    <name>A0A132PJ69_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06515"/>
    <dbReference type="EnsemblBacteria" id="KWX22371">
        <property type="protein sequence ID" value="KWX22371"/>
        <property type="gene ID" value="AFM11_21150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1577"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033735">
        <property type="term" value="F:aspartate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002811">
        <property type="entry name" value="Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01958">
        <property type="entry name" value="DUF108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF108" evidence="1">
        <location>
            <begin position="140"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="251" mass="25463" checksum="B774E3C08A704A80" modified="2016-06-08" version="1">MTVMGRGAIGGLVAAGLARGDVPGCSLVTALNSRSERTQVLAAIRAGDVVVEATTVESAQAIIGLTVAMGRDIVVCSAGALAEPNFLPQLSGPGRIILPAGAIGGFDLLAAAARADRGEARAQHITVKRAAALGADPALAEPVEVFRGSARDAALRYPRTSNSSVALALATVGLDRLEVIVMADPAADCTHHTVRWSSAVGRYEFRFHNTVDPASGGKTSAITAWSVLETLSGLHRGVGPGVVVQPGGDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ79</accession>
    <name>A0A132PJ79_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851850.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22408">
        <property type="protein sequence ID" value="KWX22408"/>
        <property type="gene ID" value="AFM11_19835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1301"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="196" mass="21428" checksum="9A4EC1B4EEEE8AA6" modified="2016-06-08" version="1">MTQWPGDSETKPAPEPLSRIQALVNTVELPDGADRLADTANATPWLVGNGLLGDGENPTDAELRLVREVREALRALLVHNAGGPPPDNESLDTLRRVAAGGAIRAEIADDDTVELFAAGDTVAQRLVELLLVMRDAQRDGTWARLKACANDECAWAFYDRSRNHGGTWCDMADCGNKLKNRDFRARRRAENRRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJG5</accession>
    <name>A0A132PJG5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851933.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11435"/>
    <dbReference type="EnsemblBacteria" id="KWX22489">
        <property type="protein sequence ID" value="KWX22489"/>
        <property type="gene ID" value="AFM11_20280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1390"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="485" mass="50776" checksum="7CEBE828E8ACFFB2" modified="2016-06-08" version="1">METTSTTELAYLSATEALAAFRRLELSPLEVLEAQIARIEAHNGDRATGINAFTEMLFDEARPAARHAADTYARCARTGETPPALLGLSVATKEKHGIAGRLLEQGLVAKRGQLAQHDHPVVERIKSAGGIIHARTTSPEFSCATVTHSPMWGVTRNPWNPQTSPGGSSGGAGAALAAGFATLATASDIAGSTRIPAGFTGTVGYKAPYGRIPGLPPLAADWYRGDGPMGRTVADVALLSSVMSGRHPVDHGSWGPNGQPIPLHGGVESLRIGLSVRLGDFPVAPEIVENTHAVAAALTAAGADVVDVELPWTTVMIRETIFAHFGHILGPAVARETAGTEDQLAAYTRRFVADAAAAAQRHTLVDSLAMDARLQADLATAMRGIDVLLCPTSAVTSLQADGDYLDGIDTAGRHLEHYWEGHLTSPFNVANHCPALSVPSGLSAEGVPTGVQVVGHPHDEAMTFRVAQAVETLVGFEIEAGNLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJM6</accession>
    <name>A0A132PJM6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851978.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11185"/>
    <dbReference type="EnsemblBacteria" id="KWX22531">
        <property type="protein sequence ID" value="KWX22531"/>
        <property type="gene ID" value="AFM11_19845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1303"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08298">
        <property type="entry name" value="CAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014187">
        <property type="entry name" value="ADH_Zn_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02822">
        <property type="entry name" value="adh_fam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="10"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="332" mass="35092" checksum="18B15FEC0C9D1D9D" modified="2016-06-08" version="1">MTAWQVVRPGPVETRPLERVTVPRPDPAAGELLVAVRSCGVCRTDLHVAEGDLPVHRPRVIPGHEVVGEVVAVGPDAEGFSTGDRVGIAWLRHTCGECDYCTRGRENLCPRSRYTGWDADGGYAEFATVPAAFAHRLPRGYTDTELAPLLCAGIIGYRALARTDLPAGGRLGIYGFGGSAHLTAQVALAQGARVHVMTRGERARELALALGVASAQGSADMPPEPLDAAILFAPVGDLVLPALAALDRGGVLAIAGIHLSDIPSLNYQKHLFQEREIRSVTANTRADARDFLAFVADHRVQVTTPEYGLGRADQALADLSAGRIAGAAVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJY7</accession>
    <name>A0A132PJY7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19370</name>
        <name evidence="2" type="ORF">AWC31_15455</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851711.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15455"/>
    <dbReference type="EnsemblBacteria" id="KWX22658">
        <property type="protein sequence ID" value="KWX22658"/>
        <property type="gene ID" value="AFM11_19370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17821">
        <property type="protein sequence ID" value="ORX17821"/>
        <property type="gene ID" value="AWC31_15455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1207"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX17821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="142" mass="15638" checksum="386307AD3BD172B1" modified="2016-06-08" version="1">MTDNDSRRARITSAWEAAWDRGDVDAFDDLLAGGYRRISGTGTSHGRDEFKASITATRSAFPDLLTVVDEVVVEGDRAAIRWHSTGSHEHSFLGVPATKRQVEVSGATFARFENDRIVEEHVTWDPRALLTALGIIAVGQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK52</accession>
    <name>A0A132PK52_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851525.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_14890"/>
    <dbReference type="EnsemblBacteria" id="KWX22567">
        <property type="protein sequence ID" value="KWX22567"/>
        <property type="gene ID" value="AFM11_18800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1095"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="143" mass="15941" checksum="406C7CAEBE57706F" modified="2016-06-08" version="1">MGHRHAMATAKVMRTAAFTGCGSPHGDVRVRARLRPTGLPRQSHHKSVQSPWRGRYAGQMRTSATAVPGRSPWMNDRVSVLLRLLEEHHGLHVPWELARVQVTCHIDLLSSVLRLNRQAARKHVTDAVLYEIACEIAATVTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKL7</accession>
    <name>A0A132PKL7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1775 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_18540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851361.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12565"/>
    <dbReference type="EnsemblBacteria" id="KWX22890">
        <property type="protein sequence ID" value="KWX22890"/>
        <property type="gene ID" value="AFM11_18540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1042"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453095" description="DUF1775 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="3">
        <location>
            <begin position="31"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="241" mass="24731" checksum="0C31EDB6E2BD7106" modified="2016-06-08" version="1">MPKTPRSLHLLVVSTVFAAGALLTAAPAAAHVRVDEGHQPPKGGYGIVRLIVPNESQQAATVALTVTLPDDVDLTSARTLPIPGWSASIETEPSGDGQRVSRITWRAIEKAGGLTPSEFGEFTFSAGPWPANVDSVSLLADQAYSDGSVVSWNEIAVDKDSEPEHPAPVVTLAAAESGHTGDGHGVPGDSGVESATADPTLVAAHAPAAGSWWWRATSVGGLVIALGTAAALGVVLRRTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKM6</accession>
    <name>A0A132PKM6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_18145</name>
        <name evidence="5" type="ORF">AWC31_12215</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851278.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12215"/>
    <dbReference type="EnsemblBacteria" id="KWX22853">
        <property type="protein sequence ID" value="KWX22853"/>
        <property type="gene ID" value="AFM11_18145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18751">
        <property type="protein sequence ID" value="ORX18751"/>
        <property type="gene ID" value="AWC31_12215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.986"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX18751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="231" mass="26438" checksum="1C7BB13B2E75B2ED" modified="2016-06-08" version="1">MAKLDFDALNSTIRYLMFSVFTVNPGELGEDRADVIDEAATFFKQQEERGVVVRGLYDVAGFRADADFMIWTHAEKVEALQATYSDFRRTTALGRASDPVWSNVALHRPAEFNKSHIPAFLAGEDPGNYICVYPFVRSLEWYLLEDEERRRMLSEHGMAARGYKDVRANTVPAFALGDYEWILAFEAPELHRIVDLMRDLRATDARRHVREETPFFTGPRVSVEDLIAKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKS5</accession>
    <name>A0A132PKS5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_16320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850584.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20000"/>
    <dbReference type="EnsemblBacteria" id="KWX22946">
        <property type="protein sequence ID" value="KWX22946"/>
        <property type="gene ID" value="AFM11_16320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.612"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="254" mass="25610" checksum="74CD6F1189BD556A" modified="2016-06-08" version="1">MSPNITRLAGRTALITGSTGGLGVAVAAALAAEGAFVVVSGRDKERGDAVVADIRAAGGRAEFVAADLGAGEPEVRRLAEQAVAAAGGQLDILINNAALWAMPEPSEEISEQTLLASYRTNVIAPFLLTGALAPAMAERGHGAVVNIGSITGLIGGDKSALYNSTKAAVHSLTKSWAAEYGPRGVRVNAVAPGPIATERAADVADEVAPVLARIPSRRMSTPEEVAAAVVFLAGDDAANIRGVILSVDGGRAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKZ5</accession>
    <name>A0A132PKZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,4-dienoyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_16790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850754.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01360"/>
    <dbReference type="EnsemblBacteria" id="KWX23025">
        <property type="protein sequence ID" value="KWX23025"/>
        <property type="gene ID" value="AFM11_16790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.711"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="6"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="374"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="669" mass="72003" checksum="A168071BA377BE29" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL46</accession>
    <name>A0A132PL46_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850852.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01650"/>
    <dbReference type="EnsemblBacteria" id="KWX23075">
        <property type="protein sequence ID" value="KWX23075"/>
        <property type="gene ID" value="AFM11_17080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.769"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453102" evidence="1">
        <location>
            <begin position="23"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="465" mass="50114" checksum="CC2FE5F8588A49F0" modified="2016-06-08" version="1">MHARRLCAAAVAALTTASVVSACGSQTGGTVINYYTPANEAATFTAVAKRCNEQLGGRFRIEQRNLPKGADDQRLQLARRLTGNDKSLDVMALDVVWTAEFAEAGWALPLSDDPAGLAEADAMENTLPGPLETARWQDKLYAAPITTNTQLLWYRADLMPEPPSTWDDMVATATRLHAAGEPSWIAVQGKQYEGLVVWFNTLLESAGGQVLSDDGQRVTLTDTEEHRAATVKALQIIKSVATAPGADPSVTQTDETTARLALEQGKAALEVNWPYVLPSLLENAVKGGVSFLPLNEDPALEGSINDVGTFAPSDEQFRVAFEASKKVFGFARYPGVQPGEPARVTLGGLNLAVAKTSQHKAEAFEAIRCLRNVENQRYTSIEGGLPAVRESLYDDPAFQMKYPQYDIIRQQLTDAAVRPATPVYQAVSTRMSATLAPISDIDPEKTADELADAVQKAIDGKGLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL74</accession>
    <name>A0A132PL74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850708.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01235"/>
    <dbReference type="EnsemblBacteria" id="KWX23004">
        <property type="protein sequence ID" value="KWX23004"/>
        <property type="gene ID" value="AFM11_16665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.683"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="132" mass="13881" checksum="FAE69D83099625FC" modified="2016-06-08" version="1">MDEQIVVAGALISGAALLVAQRDRPAALAGLWELPGGKVAAGESDAAALVRELREELGVEVTVGARLGADVALSDAMTLRAYRVSLTAGSPQPHDHRALRWVRADELDGLAWVPADRAWVADLASALRSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM11</accession>
    <name>A0A132PM11_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">AFM11_16120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850473.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16725"/>
    <dbReference type="EnsemblBacteria" id="KWX23333">
        <property type="protein sequence ID" value="KWX23333"/>
        <property type="gene ID" value="AFM11_16120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7349"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="26077" checksum="5CC64BB31284F8C4" modified="2016-06-08" version="1">MTTVDLNADLGESFGVWQLGDDEAMLGVVTSANVACGFHAGDPALLLRTCRTAAQRGVAVGAQVSYSDLAGFGRRFIDVTPEDLTADVIYQIGALQAIAHAAGTTVNYVKPHGALYNTIVSHREQAAAVAAAVAAVDAGLPVLGLSSSVFFAEASARGLRTVPEAFADRAYRPDGTLVSRRERGSVLHDPGEIAERVSSMVMSGQVAAIDGTIIPITTESICVHGDSPGAVQIATTVRERLVADGIELAAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM69</accession>
    <name>A0A132PM69_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFM11_14195</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849744.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09205"/>
    <dbReference type="EnsemblBacteria" id="KWX23436">
        <property type="protein sequence ID" value="KWX23436"/>
        <property type="gene ID" value="AFM11_14195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6945"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="21" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453402" description="Phosphoenolpyruvate-protein phosphotransferase" evidence="17">
        <location>
            <begin position="27"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilisers_N" evidence="20">
        <location>
            <begin position="34"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="18">
        <location>
            <begin position="181"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="19">
        <location>
            <begin position="281"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="464"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KWX23436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="582" mass="59090" checksum="69C66B01C7600EE3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM72</accession>
    <name>A0A132PM72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850976.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01985"/>
    <dbReference type="EnsemblBacteria" id="KWX23132">
        <property type="protein sequence ID" value="KWX23132"/>
        <property type="gene ID" value="AFM11_17400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.834"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="172" mass="19420" checksum="19653DF148F86A6A" modified="2016-06-08" version="1">MKRQHQRHDAGEAAEWFAGRLPENWFAGDPAVIVDREEITVIGRLPEPADGESEARASGRAARFREETRGERMRIADEAQDRFCRKVSWGVEVGTPPERILFTHIAVPVMTRLRQPERQVLDTLVDAGVARSRSDALAWSVRLVGEHTEEWLAKLREAMKTVDDLRAEGPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMC0</accession>
    <name>A0A132PMC0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_16195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850502.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16800"/>
    <dbReference type="EnsemblBacteria" id="KWX23347">
        <property type="protein sequence ID" value="KWX23347"/>
        <property type="gene ID" value="AFM11_16195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7364"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="202"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="367"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="451"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="557"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="700" mass="73916" checksum="252E69AD83A62686" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMM5</accession>
    <name>A0A132PMM5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_14175</name>
        <name evidence="6" type="ORF">AWC31_09225</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850061.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09225"/>
    <dbReference type="EnsemblBacteria" id="KWX23589">
        <property type="protein sequence ID" value="KWX23589"/>
        <property type="gene ID" value="AFM11_14175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09280">
        <property type="protein sequence ID" value="ORX09280"/>
        <property type="gene ID" value="AWC31_09225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6941"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="211" mass="23266" checksum="1A55795C3875012F" modified="2016-06-08" version="1">MAHIASRGPGRPPAAKAAETRERILHAAREVFSELGYDAATFQAIAIRADLTRPAINHYFGSKRVLYREVVEQTNTTVIAAGIARAREATTLLGRLSAFFAAAMDAESADRSAAAFLVTSVLESQRHPELVSEEHDALKNSREFVEWAVNDAIERGELNTDTDIPAIVEMLVAVMWGMGFYAGYVGRQGELGIIVDKFEMLMANKLWQLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMQ3</accession>
    <name>A0A132PMQ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_12495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848923.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02755"/>
    <dbReference type="EnsemblBacteria" id="KWX23620">
        <property type="protein sequence ID" value="KWX23620"/>
        <property type="gene ID" value="AFM11_12495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6589"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="488" mass="51840" checksum="5D625FBEF7DDFF77" modified="2016-06-08" version="1">MSSPDGSQVLRREFSLWSAFAFAFAFISPIVALYAIFGLALAAAGPSFWWGFALVFAGQLLVALVFAMLVSRWPLEGSIYQWSRRLLGTSYGWFAGWTYMWTLVIAMATVALGAAGFVANIAGVETPSGGLRAVIALVILIGGTAINLVGRGALKAFMTASIVAEVIGSIGLGTWLLLFHRQNSLSVLFDGGGPDIDMWAYLSGPFLIAVAFIGFSFVGFESAGAIAEEVHEPRRDLPKAVLFSLAFIALVVAYSSLAIILAIPDLDAVVSGSVADPVYETLTAALGHGIAKPVEVLFVIGFLASFLALQTSASRVIWAYARDGALPASAALARLRGKARIPVVAILVTTVIGGALFLLSIVAGDIYSLMVNFTSGGFYLAFLFPLIGFVVVVLRRGWTDGAFSLGRATVPVAVVAAVWAVLQMLNISWPRAVYEQRYLDWSVWIAVAVLFVVGLAILLTVRHRIVSAAVIDDIEAADEHADITVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMZ5</accession>
    <name>A0A132PMZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_13050</name>
        <name evidence="2" type="ORF">AWC31_03335</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849197.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03335"/>
    <dbReference type="EnsemblBacteria" id="KWX23710">
        <property type="protein sequence ID" value="KWX23710"/>
        <property type="gene ID" value="AFM11_13050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11169">
        <property type="protein sequence ID" value="ORX11169"/>
        <property type="gene ID" value="AWC31_03335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6703"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="168" mass="19055" checksum="B0EAD9F14710F94A" modified="2016-06-08" version="1">MTAIGDIRDVIVATLDEHELVYHHHEGAHGGLPGIVVELPGERRLVTNTILSIGEHSVRVEAFVCRKPDENFEGVYRFLLKRNRRLYGVAYTLDNVGDIYLVGRMALSAVTPDEIDRVLGQVLEAVDSDFNTLLELGFRSSIQKEWEWRVSRGESLKNLKAFEHLIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN17</accession>
    <name>A0A132PN17_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12945</name>
        <name evidence="3" type="ORF">AWC31_03230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849150.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03230"/>
    <dbReference type="EnsemblBacteria" id="KWX23693">
        <property type="protein sequence ID" value="KWX23693"/>
        <property type="gene ID" value="AFM11_12945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11152">
        <property type="protein sequence ID" value="ORX11152"/>
        <property type="gene ID" value="AWC31_03230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6681"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="132" mass="13721" checksum="0A3209D8807B85D5" modified="2016-06-08" version="1">MPTSTPSSPPPPQRSLVTTVGFCFWLVAAVLLMVGGMIAASVSLPGLDTLVFRGTGVLTALAGIGMAFLAGRSRSGDPRFRRAAIALSLAIVVIVALTARFGVVHILTLFGVVLLIIGTILNALPKPRRDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN77</accession>
    <name>A0A132PN77_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_13525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849418.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03770"/>
    <dbReference type="EnsemblBacteria" id="KWX23786">
        <property type="protein sequence ID" value="KWX23786"/>
        <property type="gene ID" value="AFM11_13525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6800"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="PTHR10003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453486" description="Superoxide dismutase [Cu-Zn]" evidence="9">
        <location>
            <begin position="23"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Cu" evidence="10">
        <location>
            <begin position="81"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX23786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="234" mass="23165" checksum="E4D4C78145638FB6" modified="2016-06-08" version="1">MLKSVGVAVLFAVPVVALSACAPNEPVATQPGTTPAIWTGSPSPTAPGGEHGGEHGSGATSGGETLTADIKTADGTSVATADFQFADGFATVTVETTAPGLLAPGFHGLHIHSVGKCEANSVAPTGGAPADFNSAGGHFQVPGHTAHPASGDLSSLQIRQDGSGKLVTTTDAFTAEDLQAGTKTAIIIHEKSDNFANIPPERYQQVNGTPGPDQTTMATGDAGSRVACGVIGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN99</accession>
    <name>A0A132PN99_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiazole synthase</fullName>
            <ecNumber evidence="4">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">thiG</name>
        <name evidence="7" type="ORF">AFM11_13730</name>
        <name evidence="8" type="ORF">AWC31_03975</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03975"/>
    <dbReference type="EnsemblBacteria" id="KWX23818">
        <property type="protein sequence ID" value="KWX23818"/>
        <property type="gene ID" value="AFM11_13730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11273">
        <property type="protein sequence ID" value="ORX11273"/>
        <property type="gene ID" value="AWC31_03975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6842"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <feature type="domain" description="ThiG" evidence="6">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX11273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="234" mass="23806" checksum="14523A1375B63642" modified="2016-06-08" version="1">MGTGGAPNLAVLEEALVASGTELTTVAMRRIDAETGTGVLDLLNRLGIAALPNTAGCRGAAEAVLTAQLAREALGTDLVKLEVIADERTLLPDAIELVKAAEQLVDDGFIVLPYTNDDPVLARRLEDTGCAAVMPLGSPIGTGLGISNPHNIEMIVEQAGVPVVLDAGIGTASDAALAMELGCDAVLLATAVTRASDPPTMAAAMSAAVTAGYLARQAGRIPKRFWAQASSPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNC6</accession>
    <name>A0A132PNC6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_13800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849509.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04040"/>
    <dbReference type="EnsemblBacteria" id="KWX23830">
        <property type="protein sequence ID" value="KWX23830"/>
        <property type="gene ID" value="AFM11_13800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6856"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="26116" checksum="A3FB97C4CED5A92E" modified="2016-06-08" version="1">MFDLDNRSVLVTGGSKGIGRGIATVFARAGANVAVAARSSADLDACVADLDSLGSGKVIGVVTDVSDRRACDELAAAALEAFGGLDVVCANAGIFPDAPLATMTPEQLTEIFAVNVNGTFFAVQACLDALIASGSGRVILTSSITGPITGYPGWSHYGATKSAQLGFMRTAAIELAPHKITVNAILPGNIMSEGMIENGDEYIASMAKSIPAGALGTPEDIGHLAAFLATKEAGYITGQAIAVDGGQVLPESLDAIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP55</accession>
    <name>A0A132PP55_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="9">PEP carboxykinase</shortName>
            <shortName evidence="9">PEPCK</shortName>
            <ecNumber evidence="9">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="9">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pckG</name>
        <name evidence="12" type="ORF">AFM11_12105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848597.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09870"/>
    <dbReference type="EnsemblBacteria" id="KWX24095">
        <property type="protein sequence ID" value="KWX24095"/>
        <property type="gene ID" value="AFM11_12105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6500"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
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    </dbReference>
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        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
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        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="11">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="10">
        <location>
            <begin position="245"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="386"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="272"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <location>
            <begin position="514"/>
            <end position="517"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX24095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="606" mass="67376" checksum="3C9CEB88FC920EB5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP71</accession>
    <name>A0A132PP71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849513.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23832">
        <property type="protein sequence ID" value="KWX23832"/>
        <property type="gene ID" value="AFM11_13810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6858"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
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    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
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        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="222" mass="24185" checksum="A90A05ACFF9FBABD" modified="2016-06-08" version="1">MLVDERGRGSESADVAGRIRAAILDGEYAPNQRLVEADLCEQFAVSRSAVRGALQELATQGLIERIQNRGARVRSVSLEEAVEITEVRMVVEGLCAAKAAQHITDEQIAELAELRAELTASVESGDVMGYSKLNQLLHKRVREIGAQHTAADILERLRGQLVRHQFRLAMHPGRITVSLAEHVAIIDTVCAKDPQRAEAAMRDHLKSVIVALKDVAAAQQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPD5</accession>
    <name>A0A132PPD5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847080.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05820"/>
    <dbReference type="EnsemblBacteria" id="KWX24206">
        <property type="protein sequence ID" value="KWX24206"/>
        <property type="gene ID" value="AFM11_09405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5918"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="320" mass="33708" checksum="BEFE8EAB6F902107" modified="2016-06-08" version="1">MSQQTDGLHLVLGDEELLVERAVAEVLRDTRKQAGSDDVPVDRLRAGDVSTSELAELLSPSLFAEQRLVVLESAAEAGKDAVSLIASAAADLPPGTVLVVIHSGGGRAKALADQLKKLGAQVHPCARIVKPAERADFVRGEFRRLRAKVSDDTVSAVLDAVGSNIRELAAVCSQLVADTDGQVDAAAVRRYHSGKAEVKGFDIADKAVLGDVSGAAESLRWAMLAGEPHVVLADALAEAVHTIARVGPLSGDPYRLAGELGMPPWRVQKAQKQARRWSRDSVAEAMRVVAALNADVKGAAADADYALEAAVRRVAELASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPL6</accession>
    <name>A0A132PPL6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_09820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847305.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05405"/>
    <dbReference type="EnsemblBacteria" id="KWX24280">
        <property type="protein sequence ID" value="KWX24280"/>
        <property type="gene ID" value="AFM11_09820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6002"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="227" mass="25423" checksum="DA96AF5F1DABEAE7" modified="2016-06-08" version="1">MKYGNGWRPAPVDWSSTRGRILLAASALFAQRGYFGTSTRDIAEAVHIRQPSLFHHFDAKQTIFRTLIELDLGPSIDRLQERIGEDSTWAEKLHLTAALDVQDALSQPFDSRGLYQDAVLAQEGFDDERDGIELFHRLVESLIIGGQHSGEFVEIDPTFFQRALNGVLFETIREQGGPDGPIRRGRPLDAADFLLRAVLVDPGVLPVVRETTKRRLADMTAPSRMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPR2</accession>
    <name>A0A132PPR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_10130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847471.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24329">
        <property type="protein sequence ID" value="KWX24329"/>
        <property type="gene ID" value="AFM11_10130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6062"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004707">
        <property type="entry name" value="MmpL_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00833">
        <property type="entry name" value="actII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="790"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="861"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="907"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="52"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="601"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="952" mass="103358" checksum="AF98CB215B0EC4FE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ08</accession>
    <name>A0A132PQ08_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847643.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18920"/>
    <dbReference type="EnsemblBacteria" id="KWX24385">
        <property type="protein sequence ID" value="KWX24385"/>
        <property type="gene ID" value="AFM11_10485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6137"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="26773" checksum="D55D50433C92FBA0" modified="2016-06-08" version="1">MNTTAQRISLWITPFFGGVLLIAVLAFPGFWPPMSPQLTADQVAEFYRQNSTMIRFSMITLNLCAIMLVPFFMVIVVQMKRMATPSTVLAYSYLAAVSTGATMFAIADIFWLVAAFRPDRDPQLTMLLNDFAWFIFVAPVGFVVVANLILALAVWLDARPEPVFARWVVWVNLVAAAAMTPAVGSVIVQSGPFAWDGVVSFWLRWGAFVVYLVLMFVAVHGAIRRQRAEKTLPDKATAAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ11</accession>
    <name>A0A132PQ11_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10695</name>
        <name evidence="5" type="ORF">AWC31_19210</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX16971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847756.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19210"/>
    <dbReference type="EnsemblBacteria" id="KWX24421">
        <property type="protein sequence ID" value="KWX24421"/>
        <property type="gene ID" value="AFM11_10695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16971">
        <property type="protein sequence ID" value="ORX16971"/>
        <property type="gene ID" value="AWC31_19210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6179"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX16971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="426" mass="47295" checksum="C422E816F97CF9A9" modified="2016-06-08" version="1">MAIDPTGIDFFRDERLVDNPYPFFEALRDKCPVTREDHYNVTMVTGWDEAVQVYNDEETFSSCISVTGPFPGFPVPLEGRSGEEVTALIEKHRDELPFSDQLPTLDPPTHTNHRSLLMRLITPKRLKENEDAMWQLADEVLDNFLAPGEGEFIKGFAGPFTLLVIADLLGIPDEDRESFVSGIKQHSGGGVGSTSKESLSHSPLEFLYGQFADYASDRRANPRDDVLTGLATATFPDGTLPDVGDVARVATNVFSAGQETTVRLLSTALKVLGEQPEIQQRLRDDRSLIPNFIEEALRIESPVKGDFRLSRCPVTVGETELSAGTTVMVLNGAANRDPRRFEDPDTFDPARKNARQHLAFGRGIHSCPGAPLARAETRVGLERLLDRTTDIRISDAKHGPAGERRYTYIPTFILRGLTELHLEFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQD7</accession>
    <name>A0A132PQD7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aromatic compound degradation protein PaaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847256.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05500"/>
    <dbReference type="EnsemblBacteria" id="KWX24262">
        <property type="protein sequence ID" value="KWX24262"/>
        <property type="gene ID" value="AFM11_09725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5983"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="86"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="175" mass="17949" checksum="B2308037D9F74634" modified="2016-06-08" version="1">MTAELTNPRTDGWGQKRTKTVSWHDPAPATAIGLSMAGVDYLNAVIDGILSPPPIAGLMDFAMISAEPGRVVFTCTPDESAYNPIGSVHGGLVCTLLDSVTGCAAHSALPRGKGYTSIEIKVNYLKAVRAGIGELTATGTLVKSGARVSFAEGVVTDAAGAVIATATSSLLIFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQF8</accession>
    <name>A0A132PQF8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_07755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24380"/>
    <dbReference type="EnsemblBacteria" id="KWX24570">
        <property type="protein sequence ID" value="KWX24570"/>
        <property type="gene ID" value="AFM11_07755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5402"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="487" mass="50166" checksum="D417D6003EC9F374" modified="2016-06-08" version="1">MGRQPGKGMRSSSPVSGLRRAQLSFVQVLGQSVSAVAPSAVMVTLPALVMPAAGGATLAVFVVTALLMTAVGYCVTQFSTRMVAVSGLYSYTVKGLGPIPGIAAGWSVVIGYAAAAMASTLGAASYLTALLSRLGVPGTQVTIAVLAVLVGAVALILMVRGIRLSARITLAIEVFAIAAAAAVLIIAFTGSVTGGHDPPKTSVAEAHPALGFALLLAITSYVGFESAGTVAREAQRPFLTVTRAIRWTPLALGVLYTFAAAMQSTGSIRAGIGSVPIVLTLPDSASTASVVLSTVMELGITASWFACVIGSTTALSRTLFAMGREGVVSERIGHAHRAYRTPHVALCLAVPVIVAVPVGYLFISGSSREVLVGLLAVSAHGYIGAYLLVCLATPAFLRRIGELTRTPLVIGLATAAMMVAIIGWAALTVESPVWIATAVYCALLATGFVVFAVRHRAVPDLAERVGVFDETVAGDVFADYNPWEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQG3</accession>
    <name>A0A132PQG3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846085.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24335"/>
    <dbReference type="EnsemblBacteria" id="KWX24563">
        <property type="protein sequence ID" value="KWX24563"/>
        <property type="gene ID" value="AFM11_07710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5391"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017501">
        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03062">
        <property type="entry name" value="pip_yhgE_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="664" mass="69814" checksum="943A062F5C66EB98" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQN8</accession>
    <name>A0A132PQN8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846232.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24605"/>
    <dbReference type="EnsemblBacteria" id="KWX24615">
        <property type="protein sequence ID" value="KWX24615"/>
        <property type="gene ID" value="AFM11_08005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5451"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024244">
        <property type="entry name" value="DUF2537"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10801">
        <property type="entry name" value="DUF2537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="90" mass="9229" checksum="5F50C7A4C5970241" modified="2016-06-08" version="1">MTDESTPWGTGLTVAGFVAAVLAAAIVVLGVGLIRVHPLLAVGLNMVAVGGLAPTVWGWRTRPVWRWFVLGAGIGVAVGWVALLAVALSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRE8</accession>
    <name>A0A132PRE8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845022.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12925"/>
    <dbReference type="EnsemblBacteria" id="KWX24909">
        <property type="protein sequence ID" value="KWX24909"/>
        <property type="gene ID" value="AFM11_05550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4300"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="303" mass="33187" checksum="D8BF5D32DA7658EB" modified="2016-06-08" version="1">MPDQDASQETHRHSPARVAVVQFNPQVGVEHLKANSEAVYERLHAAVAEGANLIVLPELATTGYTFESRDEAYAHAEAVPSGATVAGWVEFAAAHDVYIVGCLPELDGVELFDTAVLVGPDGYIGKYRKTHLWNEEKLFFSPGDLGYPVFHTKIGRIGLLVCWDIWFPETARIVAQQGADIICIPTGWVWTPPPLYDASGTCMAAYLTMTAAHVNNVFIATADRIGTERTSGFMGNSLIAGTNGWPIDRIAGPDEDTILYADIDITASRGAPIWNQFNDLHRDRRTDLYDQLLGYRGGTALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRK9</accession>
    <name>A0A132PRK9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845132.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11735"/>
    <dbReference type="EnsemblBacteria" id="KWX24963">
        <property type="protein sequence ID" value="KWX24963"/>
        <property type="gene ID" value="AFM11_05875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4366"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="400" mass="43428" checksum="CD708DF6CC407D5F" modified="2016-06-08" version="1">MNLDGNQASIREAIDAGLLAGAVTMVWHAGKVVQVNALGSRDVEARLPMQRDTVFRIASMTKPVTVAAAMALVEDGKVALTDPVTKWLPELSNMRVLREPRGPLDRTEPARRPITIDDLMTHRSGLAYVFSVLGPLASAYGRLSLRQDQDRWLGEVAKLPLAHQPGDRLTYSHSTDVLGIALSRIEGKPLAQVLAERIFEPLGMADTGFSVDAAGRRRAATMYKLTADNTLTHDVMGPPPITDPPFCTGGAGLFSTADDYLKFARMLLSGGTVDGVRVLSEESVRLMRTDRLTAEQQQYPFLGAPFWVGRGFGLNLSVVTDPAKSRQLFGPGGLGTFSWPGAYGTWWQADPSADLILIYLIQNHPDMSVDAAAISGNTSLAKLQSAQPKFVRRTYQALDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRM5</accession>
    <name>A0A132PRM5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ORF">AFM11_06005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845168.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29655"/>
    <dbReference type="EnsemblBacteria" id="KWX24986">
        <property type="protein sequence ID" value="KWX24986"/>
        <property type="gene ID" value="AFM11_06005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4392"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX24986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="309" mass="32488" checksum="B7C1DFDA4D4BEA98" modified="2016-06-08" version="1">MRLVFAGTPEPALPALRRLIESPNHDVVAVLTRPDAAAGRRGKPAPSPVARLAIEHDIPVLRPARPNDDEFVAELRELAPDCCAVVAYGALLSQRLLAVPPHGWINLHFSLLPAWRGAAPVQAAIAAGDSVTGATTFLIEPALDSGPVYGVVTETVRDTDTAGELLDRLAISGAMLLETTLDGIADGSLTAVPQPADGVTVAPKITVESARVRWELPAHVVDRRIRAVTPNPGAWTMIGDLRIKVGPVTVAESADPLPPGAIRVGRNSVEVGTGSHPVRLGQIQPPGKKLMNAADWARGARLDESVHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRP9</accession>
    <name>A0A132PRP9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-5 sterol desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29565"/>
    <dbReference type="EnsemblBacteria" id="KWX25003">
        <property type="protein sequence ID" value="KWX25003"/>
        <property type="gene ID" value="AFM11_06110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4414"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="3">
        <location>
            <begin position="88"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="312" mass="35580" checksum="304FA9FA78372EEA" modified="2016-06-08" version="1">MVDAMRIGLYAMPAFFVLMAIEFLSYRFDKDNPRPRAGISWRDSSTSLSIYALGYLVRPLERFIEVPIVAIAAAFAPMQLSAAHWWVWVVAIVSADLAYYVKHRMSHRIRLFWAAHSVHHSSQHFNLSTAVRLPWLIPGSFLSSIVYVPLAVIGIPVWLIFLSQAIVLLYQFPIHTERIDRLPRLIEFLFNTPSHHRVHHGANNPYLDKNYAGILIVWDRMFGSFAPEDEPVRYGLTKNIDTYNPVKANFHEFTAMVGDVWRARTWRGRLGYVLRPPGWREDPDTAGAVVSEPDTHEFSPSGQSKVASAPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRS2</accession>
    <name>A0A132PRS2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845258.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29380"/>
    <dbReference type="EnsemblBacteria" id="KWX25036">
        <property type="protein sequence ID" value="KWX25036"/>
        <property type="gene ID" value="AFM11_06295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4453"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453275" evidence="1">
        <location>
            <begin position="26"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="442" mass="47266" checksum="64302545C02FB2FC" modified="2016-06-08" version="1">MKIPMLRRRPVRPKATRWLPAIAMAAGLVLAGCAGTGGPDEQSASGLGDIPTDTNATVRVLMENVPDTDIVKNLVGQFNQKYPGIKVQIETMTFDQMRDRLVSSFQAAEPAYDLIVVDNPWMDDFADAGFLAPLGDRIASTTDYRPDDFFPSLTAITDVDGTTYGVPFYNYALGYIYNKPDLAASGQQVPTDLDALIATSQRLKTPDRAGIAMQPQRGYKIFEEWANWLFAAGGSIYDQDGKPTLNTEQAARALNAYIDTYRTAAPPNSLAWGFDEAFRSVSSGKAASMIGYNWNLPALNDPAGASGERAGQFALAPIPGGKSALGLWSWAIPANSAASDAAWAFVSWVTSPDVDAQRVADGGAVIRQSSLTDQKVLADGYGADYYKTVGEILKNAEPLSQGKGGEEMIQAVGTELNDAAAGNKSVADALRDAQAAAERIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS42</accession>
    <name>A0A132PS42_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_06910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845493.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28740"/>
    <dbReference type="REBASE" id="146315">
        <property type="entry name" value="MwoCDC01ORF6905P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25143">
        <property type="protein sequence ID" value="KWX25143"/>
        <property type="gene ID" value="AFM11_06910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4581"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="331" mass="36494" checksum="E8EECDC521D80CCC" modified="2016-06-08" version="1">MPAEPSTKATAWAIFDRIVSDAAPAGRHSNPWVHSDGGPAYVPDFRVLRKLLGVPLHLNAPSTTGVPALALDVWLSYELRRAGFEPDAVWPRPTDPRIMPSAIANLLDALPQKERVLIEQRLRRSMKGVAGSSASVLGKHYMKQVDVVISDWDTGPELLISTKRMDSSFGKNAANRVEESYGDAKNLRLRHPLAALGFVYGLRSTILNTEPEKAEWLIDLLGKLGTEDDAYHAVALVMIDYDAEVPREDDEVDSIEKAEPDTLFEIVDVETAAVDEALAALPDIAIRHDAVPPQLQPARFLATMVSRVLDISPVTRHREARRRRNTPGQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS51</accession>
    <name>A0A132PS51_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisI</name>
        <name evidence="9" type="ORF">AFM11_06895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845485.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28755"/>
    <dbReference type="EnsemblBacteria" id="KWX25140">
        <property type="protein sequence ID" value="KWX25140"/>
        <property type="gene ID" value="AFM11_06895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4578"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="117" mass="12638" checksum="0289DCE83602DBD3" modified="2016-06-08" version="1">MSLDPKIAARLKRNADGLFSAVAQERGTGKVLMVAWMDDDALARTLETREATYFSRSRGEQWVKGATSGHTQYVHSIRLDCDGDTVLLEVDQIGAACHTGAHTCFDADLLLGGEPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS79</accession>
    <name>A0A132PS79_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845275.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29320"/>
    <dbReference type="EnsemblBacteria" id="KWX25047">
        <property type="protein sequence ID" value="KWX25047"/>
        <property type="gene ID" value="AFM11_06355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4465"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="103"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="389" mass="41807" checksum="01D95DE6E736F26A" modified="2016-06-08" version="1">MGELTTAVEGTNKGELFTSFDVDAFEVPGGRDELWRFTPLKRLRGLHNGSAPVTGSALIEVSERPGVTVETVERGDERLGQGGVPADRVAAQAYSSFGHATIVTVGRNTQVEEPIEITVSGPGAGSTAYGHLQIRVDELAEAVVVIDQRGSGTYADNVEFVIGDAAQLKVVSIADWADDAVHVSMHHATLGKDAVLRHFAVTLGGDVARLTGRVRFCAPGGDAELLGLYFADDGQHFESRLLVDHAQPNCRSHVTYKGALQGDPDTDKPDTHTVWVGDVLIRAEATGTDTYEVNRNLVLTDGARADSVPNLEIETGEIVGAGHASATGRFDDEQLFYLQARGIPEDQARRLVVRGFFGELIQKIAVPSVRERLTEAIEHELALTEGIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSQ0</accession>
    <name>A0A132PSQ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845736.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25217">
        <property type="protein sequence ID" value="KWX25217"/>
        <property type="gene ID" value="AFM11_07345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4669"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="277" mass="29427" checksum="082B458793DE3FD5" modified="2016-06-08" version="1">MSSFAPDVTPGRWLTAAEVARASNLREDLVERFLPAMEPPEALYSGDLVSIARFVKQLTDLGTPAAAIEVAVAELRARPDAAFKVALGSGRHRASFDAGKRRIWMSVGATVIAAVLVGAIATTFFGPDDTGSTTAAPATETKPVPAEPVAPTVMHFAAIPAKADPVCGQWERASAAYGAKLQAWVKTDPRVPATRWSPKQRSVTMAVIPVMREEAAGLRQLADKARDPLLADLLRGQAMYESAYADRLPHFQPGDHALWKAASSLSGSVKAICSAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT31</accession>
    <name>A0A132PT31_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_04445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844498.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20700"/>
    <dbReference type="EnsemblBacteria" id="KWX25499">
        <property type="protein sequence ID" value="KWX25499"/>
        <property type="gene ID" value="AFM11_04445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2765"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="197" mass="21448" checksum="0DEA152FDBDFBC91" modified="2016-06-08" version="1">MATPARRTSGGPVLLDDVTAAIESAFFEELASVGYGRLSVDAVAKRAGVGKAAIYRRWKSKQDLAAELVTKVAVAAIDVPDTGNLRGDIRAYLANGRAALTHRLARTIIPDLLAEAARDPEYAATIAAQIREPRRLKAVQLFERARQRGEIADDVDLEVALDMVGGALYWRQSVMQVDADDDYLDRLTEAILTLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT34</accession>
    <name>A0A132PT34_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tautomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_07250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845691.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17465"/>
    <dbReference type="EnsemblBacteria" id="KWX25202">
        <property type="protein sequence ID" value="KWX25202"/>
        <property type="gene ID" value="AFM11_07250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4650"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037479">
        <property type="entry name" value="Tauto_MSAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38460">
        <property type="entry name" value="PTHR38460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14552">
        <property type="entry name" value="Tautomerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="135" mass="14893" checksum="931893C20728F4BD" modified="2016-06-08" version="1">MPLVRIDLLNHHGNEHIRNVADAIHRSLVAVLGIPERDRFQVITPHRPGEIIALDAGLGFDRSPDTVIIQIFTQRGRSIDTKERLYAEIAAQLETVGVRGDDIFVGIAENGPEDWSFGFGKAQYVTGELAVPEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTI1</accession>
    <name>A0A132PTI1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Guanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844803.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20050"/>
    <dbReference type="EnsemblBacteria" id="KWX25641">
        <property type="protein sequence ID" value="KWX25641"/>
        <property type="gene ID" value="AFM11_05290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2943"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="231" mass="26099" checksum="01E771E0CE411BFB" modified="2016-06-08" version="1">MNANTVPLTKALEETRTGDIWLFRGGSGPDRAIQTLTNSPVNHVGMTVAIDDLPPLIWHAELGDKLLDMWTGTNHRGVQLNDARQAVERWMHNYGQRCWLRQLTPYATREQEDALLKVIARMNGTAFPTTARLTGRWLRGRLPVVSDFTRGIPFVHSKVRESAERKKARKRQVGLETAYCAETVAITYEEMGLLTTEKRYNWFDPGSFWSGDQLPLTAGYQLGDEIAVIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTW9</accession>
    <name>A0A132PTW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842193.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33460"/>
    <dbReference type="EnsemblBacteria" id="KWX25781">
        <property type="protein sequence ID" value="KWX25781"/>
        <property type="gene ID" value="AFM11_00345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.70"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="226" mass="24763" checksum="BA8ED558E2EC71B4" modified="2016-06-08" version="1">MAYATRRQVGLAGALAVVVVAFLAYSIPPYLTGGTRVPATFALHYPLLVAHVLLASVAMVCAVAQIWPGLRRRHPGLHRRTGRVYVFTAIPAAVCAMVIGVATPFGPVLAVSNVALGALWLWFTVDGFIAGRQRRFGVHRRQMLRSVTLALSIITNRVWTPVLYLAFEPLRDSVFDGNDEHYLWAVAGLGAWLGWTLPMVVLQFWLNRRPAVSPSSVSPAARREPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU20</accession>
    <name>A0A132PU20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_00650</name>
        <name evidence="10" type="ORF">AWC31_33760</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AmiS/UreI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842350.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33760"/>
    <dbReference type="EnsemblBacteria" id="KWX25838">
        <property type="protein sequence ID" value="KWX25838"/>
        <property type="gene ID" value="AFM11_00650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11650">
        <property type="protein sequence ID" value="ORX11650"/>
        <property type="gene ID" value="AWC31_33760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.133"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003211">
        <property type="entry name" value="AmiSUreI_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038523">
        <property type="entry name" value="AmiSUreI_transpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02293">
        <property type="entry name" value="AmiS_UreI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX11650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="209" mass="22175" checksum="98841908BFDED6B0" modified="2016-06-08" version="1">MGNVGLLYVGAVLFVNGLMLLNVVPARSAAVLNLFVGALQCVLPTIMLVMADGDAAATLAASGLYLFGFTYLYVGIVNLAGLEPEGIGWFSLFVAGGAIVYAVLSFTVVDDPVFGVIWLSWAVLWLLFFLVLGLGREQLTRFTGWAVVLLSQPTCTLPAFLMLSGNYRTTPGVAAIWAIGLASLLVAARLLSSPRSHRSRTTASQPVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU93</accession>
    <name>A0A132PU93_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Mycofactocin system glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_00200</name>
        <name evidence="4" type="ORF">AWC31_33310</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842115.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33310"/>
    <dbReference type="EnsemblBacteria" id="KWX25757">
        <property type="protein sequence ID" value="KWX25757"/>
        <property type="gene ID" value="AFM11_00200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11568">
        <property type="protein sequence ID" value="ORX11568"/>
        <property type="gene ID" value="AWC31_33310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.41"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023981">
        <property type="entry name" value="MftF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43646:SF6">
        <property type="entry name" value="PTHR43646:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03965">
        <property type="entry name" value="mycofact_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="85"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX11568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="470" mass="50712" checksum="8168D47832DDEEB9" modified="2016-06-08" version="1">MTGPRLPDGFAVQVDRRVKVLGEGAALLGGSPTRLLRLAPTAQNMLNGGRLEVHDALSAQLARTLLDATVAHPRPASGPSHRDVTVVVPVRDNASGLHRLIGALRGLRVIVVDDGSAIPVSPAEFAGMHCDVQVLRHSRSNGPAAARNTGLAACETDFVAFLDSDVVPRRGWLEALLGHFCDPAVALVAPRIVGLHNADNLVARYEAVRSSLDLGMREAPVVPYGTVSYVPSAAIICRRSALVAVGGFDETMQSGEDVDLCWRFVESGARLRYEPIALVAHDHRTDLRKWFTRKAFYGSSAAPLTVRHPGKTAPLVISRWTLMVWLLLAMGSCVGYFASLVVAFVTGRRIARSLSAIDTEPKEVAVVAAHGLWSSALQLCSAICRHYWPIALISAVMFRRARHAVLLAAVIDGVVDWATRRGNADDDTKPVGLLTHILLKRLDDIAYGTGLWTGVVRERHLGALKPQLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUD6</accession>
    <name>A0A132PUD6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844838.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21770"/>
    <dbReference type="EnsemblBacteria" id="KWX25662">
        <property type="protein sequence ID" value="KWX25662"/>
        <property type="gene ID" value="AFM11_03315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2537"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="61"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="364" mass="39978" checksum="F3BC479F8A860208" modified="2016-06-08" version="1">MWQPTRRQVLQIGGLGAAATVVGGGVLAAVSDGGSDQLPAPASGTQIRTNIPGSDISLPAVGLGTFQTFDALPEDARAQRVEVLRRFWEAGGRVVDASPLYGTSEENIARYAVPTGIQNDIFLSNKIWSTGAHLWDESHALESLNTSMQRLSRTKPIDVMQCHSLVNVETIVPILHAWKAEGRISRIGVTHHDPAYFGQLANWVRTGDVDFVQTRYSIAERSAEQQVFPVATDRGVTVMVNMPLEKGRLHQLVGDRPLPDFVADLGIRSWSQYFLKWVISHPAVAVALPATSVPDHVVDNMAAARGPMPDAAMRARMLEHVQGIPGFDDVTRQPWYPGKRYPGIVNRDMRAIQERSSWRPAGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUD7</accession>
    <name>A0A132PUD7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01300</name>
        <name evidence="3" type="ORF">AWC31_34335</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842687.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34335"/>
    <dbReference type="EnsemblBacteria" id="KWX25946">
        <property type="protein sequence ID" value="KWX25946"/>
        <property type="gene ID" value="AFM11_01300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11746">
        <property type="protein sequence ID" value="ORX11746"/>
        <property type="gene ID" value="AWC31_34335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.266"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="51"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="293" mass="32014" checksum="F57975BC27DC7B05" modified="2016-06-08" version="1">MPAAKQPRQQAGAISQILRRVRRGSRDVIDSAVSQLFDAAVHPDGVAASGEYRIDELAQLAGTTTRNIRVYRDRGLLHPPLRVGRIALFNDTHLTRLRLITSMLDRGYNIAHVHEMLSAWEQGKDIGDVLGLEDAIAGSWATEKSQRMPLADGKRLIDDDAAFDRLVGNGVIKLDDGDAIIVRPKLIEAFNEIRQYGVGIDTLIDIHEQVVPHLDEISAILVRAGVDQVAEKIKPGASLPADTEVAELITMLVRFRTQAVAAVSATLASSIESTIESVVSEMLTEYVEKAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUF4</accession>
    <name>A0A132PUF4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842551.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25904">
        <property type="protein sequence ID" value="KWX25904"/>
        <property type="gene ID" value="AFM11_01030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.211"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="244" mass="25229" checksum="4709F26466A0BAD2" modified="2016-06-08" version="1">MFLKAAINGGRSRAEAPTVPLTPEEIATDASRAISLGAAVVHAHARTADGGQSIHPDDIGAMVRAVRATDTSVIIGTTTGLWTCSGHDERMRHVAGWPDGALPDFASVAFSEEGAAEAAQLLVSRGVVLESAVWSIDDVPSLLSSPTLHQNVRILIEPETADADQAIAECRQIAAILRDAGATCSILYHGQDGTAWPVLRAAVEDGVEARIGLEDVTCDSAGSAADNAAMISEALAIGRSCPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUG6</accession>
    <name>A0A132PUG6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842735.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25955">
        <property type="protein sequence ID" value="KWX25955"/>
        <property type="gene ID" value="AFM11_01370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.281"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="144"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="306" mass="33442" checksum="D1D6F929BCAFCEC6" modified="2016-06-08" version="1">MALHRLDSIVLGVPDVAAVADFYRDFGLLDVGDGYFATLDGGRQLRLVPAPSRRLVSAVFAVDDADDLCRASKALAGIGVSSTVDDERLTTVEPTTSVSIELIAMPRLIQARFDAAPVNAPGRIDRVNARAAGVTASGPVRPRRLGHIVLGSPDFERCRSFFVDALGFKVSDVVRDVGVFLRCSTDHHNVLVQRAPVPFIHHSSWQVDDVDAIGRGAMGLLEEHPERHVWGLGRHYAGSNFFWYFRDPAGNFAEYHSDMDHIPEDALWTPETLEGAKGLFEWGPPPPPSFIDPDDLAELMISGHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUR5</accession>
    <name>A0A132PUR5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843074.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34885"/>
    <dbReference type="EnsemblBacteria" id="KWX26060">
        <property type="protein sequence ID" value="KWX26060"/>
        <property type="gene ID" value="AFM11_02105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.431"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="380"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="464" mass="48727" checksum="A61CD4BE5FFAE6C9" modified="2016-06-08" version="1">MLLTSLESAADAAAAITIGEQSMSRDELVSAAAALAAVLPSERPVAVHAQPTLDTVIAVTACLLAGVPVVPVPPDSGSAELRHVLTDADVACWAGPAHPGSGLPVVPTRGHPAGGAIRPPADEAIAMILYTSGTTGAPKGVNLSHRALAAGIDAVAEAWQWTADDTVVHGLPLFHLHGLVLGIIGSLRVGSRVVHTVKPRPERYAAAAGTMYFGVPTVWSRIASDADSARALRRARLLVSGSAPLPTPVFQRITELTGSSPIERYGMSETMITLSTRSDGERRPGSVGQPVAGVEARLCTEDGQAVPHDGESIGRLQVRGPMLFTDYLNRPEATAAAWTPDGWFVTGDVATRDVNGFHRIVGRESVDLIKSGGYRIGAGEVETALLTHPAVREVAVVGQPDVDLGQRVVAYVVTDSAHRTALADRLIEFVAGSLSNHKRPREIIFLDELPRNAMGKVQKKLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUT2</accession>
    <name>A0A132PUT2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_02185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843117.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26073">
        <property type="protein sequence ID" value="KWX26073"/>
        <property type="gene ID" value="AFM11_02185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.447"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017516">
        <property type="entry name" value="AbrB_dup"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007820">
        <property type="entry name" value="AbrB_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38457">
        <property type="entry name" value="PTHR38457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05145">
        <property type="entry name" value="AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038991">
        <property type="entry name" value="Protein_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03082">
        <property type="entry name" value="Gneg_AbrB_dup"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032714197" evidence="2">
        <location>
            <begin position="31"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX26073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="363" mass="37063" checksum="D397BB2F70582681" modified="2016-06-08" version="1">MRRILRWALLVVVTSAVTVPLTLVGVPSAALFAALAVGVALALASLAPDRVPRRAGVLAQGVLGVYIGTMVHQDAVDALRSDWLIVLVIAVATLLLSVVAGALLGLHRDVSPLTGSLALVAGGASGLVAIARELGGDDRVVSVVQYLRVALVTATIPLVVTLVFHADRSHPAPMAPQTASAPWYLSLAMIAVLVAVGVVGGKLIRLPGAGLLGPLALTVVLQLTGLSFGLTVPTVLVQAGYMVIGWQAGVAFTRESLRAIGRILPLALALIVVLGVATAGLGVVLANVTGVTQLEGYLATSPGGVYAVLATAVETGSNVTFIIAAQVLRVLLMLFAAPLMARGVARLSRRHVADEPVAVATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVI3</accession>
    <name>A0A132PVI3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_01990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843025.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34770"/>
    <dbReference type="EnsemblBacteria" id="KWX26042">
        <property type="protein sequence ID" value="KWX26042"/>
        <property type="gene ID" value="AFM11_01990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.407"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX26042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="157" mass="17904" checksum="91276F4242BB8EDE" modified="2016-06-08" version="1">MSAPGAGESRLGRPAPVMEREHDRPAALDHPRAPRRPRGIPYFEKYAWLFMRFSGVALVFLALGHLFVMLMWQDGVYRIDFNYVAQRWASPFWQIWDMALLWLANLHGANGMRTIIGDYARKNTTKFWLNSLLLLATGFTLVLGTYVLVTFDANIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAR3</accession>
    <name>A0A132PAR3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MCE-family protein MCE1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_36045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000074">
        <property type="protein sequence ID" value="KWX19404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23440"/>
    <dbReference type="EnsemblBacteria" id="KWX19404">
        <property type="protein sequence ID" value="KWX19404"/>
        <property type="gene ID" value="AFM11_36045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mce4_CUP1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="204" mass="21879" checksum="18201CCDB14277C5" modified="2016-06-08" version="1" fragment="single">ALDGLGDKFGRSIVDGNDILADVNPRMPQIRRDITGLADLGEIYADASPDLWDGLTNAVTTARTLNEQRGNLDQALVAAVGFGNTGGDIFERGGPYLVRGAQDLLPTSALLDEYSPALFCTIRNYHDAAPKFAAQTSNGYSIQLLDSLVGAGNPYVYPDNLPRVNAKGGPEGRPGCWQPITRDLWPAPYLVMDTGASIAPYNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB10</accession>
    <name>A0A132PB10_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_35840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000051">
        <property type="protein sequence ID" value="KWX19447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859988.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19447">
        <property type="protein sequence ID" value="KWX19447"/>
        <property type="gene ID" value="AFM11_35840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6247"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="177"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="379" mass="43074" checksum="7D010C076E4BE0A5" modified="2016-06-08" version="1">MRVVPVSDPGVGEPAVQLVDGQGRVVEDVAAFLRALTVRRFSPNTVRAYAHDLQKLMLFLEEQGLTVQDFTPARAMDFLVTLRRTPSTRKAQRLELAATVDDGRLLSPRTCNRILAAVSSFYEFLITCERYDGRENPILKQADSAALRAAGRWRPPLLNSKKQIPVRRTLRVKTVDSLPRPLPDETYRALILVMRTKRDRALLELMHEGGLRPGEALGLCLEDISYGRRRVTIRHRDSHPKGVRQKSRRERVVDLLEDRALPAINDYVLRERPQDAETDYVFLVGGGGKRRHEPLSYDGMVRMFARAAERAGVRDPWLTPHALRHTHATRMFEGGMRELTLMARLGHASPDSTKIYTRISDHEVAADYRRALESEDSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB28</accession>
    <name>A0A132PB28_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoadipate CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000044">
        <property type="protein sequence ID" value="KWX19516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040851.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19516">
        <property type="protein sequence ID" value="KWX19516"/>
        <property type="gene ID" value="AFM11_35510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5836"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="23887" checksum="FD91A1739C760C3D" modified="2016-06-08" version="1">MSRTAVCAAAHEAVAGIADGATILVGGFGMAGMPTTLIDAIIEQGAAELTIVSNNAGNGDTGLAALLAAGRVAKVICSFPRQADSYVFDRLYRDGMVDLEVVPQGNLAERIRAAGAGIGAFFCPTGVGTPLASGKEIRTIDGRDYVLEYPIRGDVALIAAHLADRAGNLLYRKTARNFGPVMATAATLTVVEVSRVVETGGIDPETVVTPGIFVDRILDLSSIPAARTEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB34</accession>
    <name>A0A132PB34_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859741.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19551">
        <property type="protein sequence ID" value="KWX19551"/>
        <property type="gene ID" value="AFM11_35265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5783"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014862">
        <property type="entry name" value="TrwC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08751">
        <property type="entry name" value="TrwC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1118" mass="119528" checksum="75A58292BE153D9E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBC3</accession>
    <name>A0A132PBC3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_34805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859485.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10950"/>
    <dbReference type="EnsemblBacteria" id="KWX19629">
        <property type="protein sequence ID" value="KWX19629"/>
        <property type="gene ID" value="AFM11_34805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5310"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="14"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="440" mass="48767" checksum="8BFBA45BECB5AF25" modified="2016-06-08" version="1">MTEPGWVAHAIWWQVYPLGFVGAFPADPAPTADEHRLRRVVEWLDHAVELGASGIALGPLFDSRTHGYDTTDHFRIDPRLGDDGDFDHLTAEAHRRGLRVLLDGVFNHVGTDFERYRQALDGGPDHPASAWFRRHGAQSEFATFEGHGELIALNHDNPDVVEYAATVMRHWLARGADGWRLDAAYAVPDRFWARVLPEVRREFPDAWFVGEVIHGDYSATVAAATFDSVTQYELWKAIWSSLNDGNFHELDWALQRHNDFLGAFVPLTFIGNHDVTRIASQLENPRHLEHALVILLTTGGTPSVYAGDESAYRGVKEDRRGGDDAVRPEFGSPSADPTQPGADVLRLHQYLIGLRRRHPWLHTATTSALSLTNTQYVYRADGDGGTLIVALNVDDAPLRLSLPEYGVPSGRVVAGSGAPPPDEVTHPEVAGHGWLIIEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBQ2</accession>
    <name>A0A132PBQ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859389.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19677">
        <property type="protein sequence ID" value="KWX19677"/>
        <property type="gene ID" value="AFM11_34665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5280"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="163" mass="18421" checksum="D33F5EEEB233EFBD" modified="2016-06-08" version="1">MKYTNSIEIALPRDTVAQLLADPAHIPKWLRGMVLHEPVSGIHGQLGTKSRVVMKSGKRTIECTETITRRDPADLHGIPKEAVVHFDREIVGPGMWSVVRDRLTEASRETTLWESESEYRFSNVLMRLVGLLMPGAFRKQSQQHMQGFKAFAEQGKDVREGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC52</accession>
    <name>A0A132PC52_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858736.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02245"/>
    <dbReference type="EnsemblBacteria" id="KWX19898">
        <property type="protein sequence ID" value="KWX19898"/>
        <property type="gene ID" value="AFM11_33505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5034"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="388" mass="43059" checksum="01CE183CBF7F1712" modified="2016-06-08" version="1">MFERLPRDTRRCANTSRRAGTVGVDVKMSGGILGLQRLAGNRATADLLHVQRQPVIEVEGILDPQQVTGAIFYYKQKPKRYTKEVINQIQVAVGTLPKDEMDAADVQAVAEWQRTKGSEFEPHLKVDGMAGPRTLPRMFQGGLGISARITVYVGEMKSILDKWDELKTPEARRLALKAEINKHLGEVGVPDVELTTGEGNQFDSTTWTIFIRASAFKELPADPAERERHTTALTSTLYHEARHAEQAFRIAAMLAGRGLTEGQIYWQTSTKKDVIKEALKPENQLKPGTMEAAIAEGWYDSQNGADSPKTHQVYAELNAAAKAFEAAEAAKEANPTPENQRRYEAAVERFKAAEAAYYDLPQENDAFRISDEIVMKFQALKKASKSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCA7</accession>
    <name>A0A132PCA7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858584.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16965"/>
    <dbReference type="EnsemblBacteria" id="KWX19960">
        <property type="protein sequence ID" value="KWX19960"/>
        <property type="gene ID" value="AFM11_33260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4984"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="421"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="506" mass="54539" checksum="F378A5177C2CC79A" modified="2016-06-08" version="1">MTSARRTVPAVLDRIAVQFSDHDALVSTDRRLTYSQLRDEVRQAAAAMVALGVQPGDRVAIWSPNTWHWVVACLATHYAGGVVVPLNTRYTASEATDILARTAAPLLIAAGKFLGADKTADLDREALPSLRHVVRVPIDEDDGTWDEFVAQSSDLDEVDRRAAAVQPDDVSDILFTSGTTGRSKGVRCAHRQSLDGSAAWAECGQVTSADRYLCINPFFHNFGYKAGILACLQTGATLIPQLTFDPEQAMKAVAEQRITVLPGPPTIYQTLLDHPKRGDYDLSSLRFAVTGAAVVPVVLIERMQNELDIDIVLTAYGLTEAAGFGTMCRPDDDAVTVATTCGRPIADFELRLDDSGEVLLRGPNVMLGYLDDPEATAAAIDADGWLHTGDIGTLDAAGNLTITDRLKDMYICGGFNVYPAEIEQVLARLDGVAESAVIGVPDDRLGEVGKAFVVVKAGAQLDEAAVIAYAREHLANFKVPRSVEFLDMLPRNPGGKVVKPVLRERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCG6</accession>
    <name>A0A132PCG6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_32885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858343.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32330"/>
    <dbReference type="EnsemblBacteria" id="KWX20006">
        <property type="protein sequence ID" value="KWX20006"/>
        <property type="gene ID" value="AFM11_32885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4906"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="254"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="480" mass="51887" checksum="7B5E2064A918BC8E" modified="2016-06-08" version="1">MSTQVAAVDLGATSGRVMVADIDGDRLDMRTVARFSNDPVRLWDGTRNALHWDIPGLYGHVVDGLTRAGRECDHLVGIGVDSWAVDYGLLRDGRLLSQPTHYRDARTERGVELVHGVVGMPELYQRNGIQFLPFNTVYQLAVERAEGMLDLADTVLLVPDLLTYWLTGERVAERTNASTTALLGLDGAWDRELMTRLGLPHALFPDVVDAGSSRGPLLPEVSAQLGLRTEVVSVASHDTASAVAAIPMDAEQAAYISCGTWGLVGVELSSPVATEASRTANFTNEVGADGRIRFLHNVMGMWLLSETLRQYERDGHDVELTDLLERAAHVPAPQEVFDTNDPRFLPPGDMPARIVDWYTERGLQAPADPARVVRAILESLAAAFASAVCTAAELSGVTVRTVHMVGGGSQNELLCQLTADRLGMPLLAGPVEATALGNVLLTARAQGIVSGGLTELRELASRWFPPRRYVPRTSRAAAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCH0</accession>
    <name>A0A132PCH0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fis family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858437.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32200"/>
    <dbReference type="EnsemblBacteria" id="KWX20035">
        <property type="protein sequence ID" value="KWX20035"/>
        <property type="gene ID" value="AFM11_32825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4894"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="1">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="428"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="489" mass="51865" checksum="EF336CF394C2886E" modified="2016-06-08" version="1">MVTVGNILAAKALGLRGVHVCRTDADIRWVATSELPDPAPFLEGGEVLLTTGLETGAWHDEWDEYIGRLAGAAVSAVGLGVGLTHARMPGELVDACRKHGVNLFEVPRRTTFVAISRHVAHLLQEQESIAAREAFKTQRRLISAAAKSDPAAAVVTALAQAVGGAACLLTPDGRVLTGPVGPRRADFPLDEVAADVRRLQAHGLRSAAAQSRPAMSVSVHPIGLRGRPSTYLATTGPTRLSDGQRHAVTTAVAVLGLVDEQQRSRAATRRHARSRAIELLAGNDSRTARLVLELDAPAPTVTERVRFLRASGSESDRRDALPALEHRGILAAPYADELCAVAPPDKAEALGTGLVDAGLQVGIGGAVSLQDGETGYRTAGLALAQTTPTAGMVVWDRVVDGGPLGLIDPDRATAFAESWLSGLDSEQLETLRCFLRHHGSRLKVAEELGLHRNTVRNRLDAIEALLPGKLDDPQTRVSAWIALQSLHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-02-10" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCH1</accession>
    <name>A0A132PCH1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mandelate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_32220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857983.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20041">
        <property type="protein sequence ID" value="KWX20041"/>
        <property type="gene ID" value="AFM11_32220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4772"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047808">
        <property type="term" value="F:D(-)-tartrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034611">
        <property type="entry name" value="D-tartrate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF5">
        <property type="entry name" value="PTHR48080:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00118">
        <property type="entry name" value="D-tartrate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="2">
        <location>
            <begin position="161"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="388" mass="42829" checksum="2EFB33F50B698A89" modified="2016-06-08" version="1">MKILSVHESVVPISSSIRNAWIDFSSMDCSIVAIVSDVMRDGEPVIGYGFNSNGRYSAGEILRRRAIPRLLDADPESLLDQAGNLDPTLAWPIMMNNEKPGGHGERSVAVGVMDMALFDLASKIAGQPLYRYLSERFGDGQPDDSVFVYAAGGYYAPGKTLSDLQDEMRRFLDMGYSVVKMKIGGADLAEDLKRIEAVLEVLDGDGSRLAVDVNGRFDLQTALEYGKAIEPYGLFWYEEVGDPLDYRLNAILSENYRGSIATGENLFSVQDARNLIRYGGMRPDRDYIQVDPALSYGLTEYLRVQEMLKEHGWSSRRCIPHGGHQFSLHIAAALKLGGNESYPGEFQPTGGFADDAVVSDSRVGLTEIPGIGFEGKSAFYKVLRELHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCI2</accession>
    <name>A0A132PCI2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33120</name>
        <name evidence="4" type="ORF">AWC31_17105</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17105"/>
    <dbReference type="EnsemblBacteria" id="KWX19937">
        <property type="protein sequence ID" value="KWX19937"/>
        <property type="gene ID" value="AFM11_33120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18109">
        <property type="protein sequence ID" value="ORX18109"/>
        <property type="gene ID" value="AWC31_17105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4956"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="232"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX18109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="315" mass="34896" checksum="B7FB4FBDDFC986FA" modified="2016-06-08" version="1">MSDLQAAVDEIKAAGRSKPRAGRDPVNQPMIHHWVDAIGDRNPIYVDEEAAKAAGHPGIVAPPAMIQVWTMAGLGQGRPDDDPLSQMMKLFDDAGYVGVVATNCEQTYHRYLQPGEDVTISAELTDVIGPKQTALGEGYFINQKITWQVGDEDVAEMAWRIMKFKPREEQKPAVPEDLDPDKLMRPAASRDTQFFWDGVNAHELRIQKRPDGTLQHPPVPAVWQDKEAPVDYVVASGTGTVFSFVVHHAPKVPGRSLPFVIALVELDEGVRMLGELRNIDPDKVQIGMPVRATYIDFPDSDVSPAWTLYAWEPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD12</accession>
    <name>A0A132PD12_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsE</name>
        <name evidence="8" type="ORF">AFM11_31270</name>
        <name evidence="9" type="ORF">AWC31_25420</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857426.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25420"/>
    <dbReference type="EnsemblBacteria" id="KWX20225">
        <property type="protein sequence ID" value="KWX20225"/>
        <property type="gene ID" value="AFM11_31270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14535">
        <property type="protein sequence ID" value="ORX14535"/>
        <property type="gene ID" value="AWC31_25420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4159"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX14535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="229" mass="25663" checksum="B2C41367E1CC516F" modified="2016-06-08" version="1">MITLDHVTKQYKSSARPALDDVSLKIDKGEFVFLIGPSGSGKSTFMRLLLAAEHPTAGDIRVSKFHVNKLRDRHIPSLRQVIGCVFQDFRLLQQKTVFENVAFALEVIGKRSDVINRVVPDVLEMVGLSGKANRLPSELSGGEQQRVAIARAFVNRPLVLIADEPTGNLDPETSKDIMDLLERINRTGTTVLMATHDHHIVDSMRQRVVELELGRLIRDEQRGVYGMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDB4</accession>
    <name>A0A132PDB4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857098.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26430"/>
    <dbReference type="EnsemblBacteria" id="KWX20328">
        <property type="protein sequence ID" value="KWX20328"/>
        <property type="gene ID" value="AFM11_30710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4044"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="261" mass="27428" checksum="9260E9214C50D47D" modified="2016-06-08" version="1">MSETARRVVVVGAGSGIGGAAAAHFHDRGDHVLAVDLRPNNTPASQHLTCDLRDAHSITALLGEIGGGWDVLAHVAGVPGTAPPADVLRVNYLGMRLMTEGMLPLLRQGGSIIGVASTAALGWEQRIDILTGLLELTAGDDVERWQAGQDPDFPVYTTSKQAAILFAKRIAGPAWSKYGVRVNTVSPGPVETPILADFEQTMGKDVLDMVRSTVGRHATVDDVVPLIAFLASPESRWINGQDIQVDAGFIAAMTGGVPIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDU2</accession>
    <name>A0A132PDU2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31110</name>
        <name evidence="4" type="ORF">AWC31_26820</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857290.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26820"/>
    <dbReference type="EnsemblBacteria" id="KWX20397">
        <property type="protein sequence ID" value="KWX20397"/>
        <property type="gene ID" value="AFM11_31110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14775">
        <property type="protein sequence ID" value="ORX14775"/>
        <property type="gene ID" value="AWC31_26820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4126"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="92"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX14775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="337" mass="37372" checksum="3F4DE5A1D5639AE7" modified="2016-06-08" version="1">MTETKEPGTDFDAPVDAAGMPAPNPHATAEQVEAAMHDSKLAQVLYHDWEAETYDEKWSISYDQRCIDYARGRFDAIVPEEEQRNLPYDRALELGCGTGFFLLNLIQSGVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYEDNTFDLVVGHAVLHHIPDVELSLREVVRILKPGGRFVFAGEPTTVGNRYARELSTLTWHATTNLTKLPWLNGWRRPQAELDESSRAAALEAVVDLHTFDPADLERMATNAGAVEVRTASEEFTAAMLGWPVRTFEAAVPPGRLGWGWAKFAFNSWTTLSWVDANVWRRVVPKGWFYNVMVTGVKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDY0</accession>
    <name>A0A132PDY0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_30585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857052.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20535">
        <property type="protein sequence ID" value="KWX20535"/>
        <property type="gene ID" value="AFM11_30585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4017"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="121"/>
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            <end position="145"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="188"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="226"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="382"/>
        </location>
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            <end position="415"/>
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            <end position="743"/>
        </location>
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            <end position="75"/>
        </location>
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            <end position="773"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KWX20535.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="773" mass="79361" checksum="3DFE71F9A7261DCD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE07</accession>
    <name>A0A132PE07_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20524">
        <property type="protein sequence ID" value="KWX20524"/>
        <property type="gene ID" value="AFM11_30190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3934"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="80" mass="9223" checksum="11BF053FF8E6F257" modified="2016-06-08" version="1">MWVLRHPKGRFFQSEPRDIDHASSSNVTQELNRLVQLGMLDVEHPEDSRRVYYVRTNSPLWDIITAAIEAIDAEAAESGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE56</accession>
    <name>A0A132PE56_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH:ubiquinone oxidoreductase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
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        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KWX20610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25240"/>
    <dbReference type="EnsemblBacteria" id="KWX20610">
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        <property type="gene ID" value="AFM11_29900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3872"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
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        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
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        <property type="entry name" value="NU5C-like"/>
    </dbReference>
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        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
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        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
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        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="135"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="626" mass="65200" checksum="FE2CC76716F4DB4C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE94</accession>
    <name>A0A132PE94_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,5-diketo-D-gluconic acid reductase</fullName>
            <ecNumber evidence="5">1.1.1.274</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dkgA</name>
        <name evidence="5" type="ORF">AFM11_28930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.274" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003889251.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20659">
        <property type="protein sequence ID" value="KWX20659"/>
        <property type="gene ID" value="AFM11_28930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3667"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050580">
        <property type="term" value="F:2,5-didehydrogluconate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="277" mass="29999" checksum="8DBB06BF32ACCF61" modified="2016-06-08" version="1">MTSSSIPTVTLNDDNTMPVLGIGVGELSEADAEQAVLAALSAGYRLIDTAAAYGNEAAVGRAVRKSGVPREEIFVTSKLDVRDQGFKSAQDACRKSVEELGLGYVDLYLIHWPAGEQGKYIDSWGGLMKNKELGDAKSIGVSNFHEEHLSNVIDLSFFTPAVNQIELHPLLNQAHLREVNKGYGIVTQAYSPLGVGRLLDNETVVSVAQAHGKTPAQVLIKWSLQLGNSVITRSRSPEHLAANLEVFDFELTDDQMAALNGLDDGTRYRPDPETYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEI0</accession>
    <name>A0A132PEI0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_29475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043416436.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20735">
        <property type="protein sequence ID" value="KWX20735"/>
        <property type="gene ID" value="AFM11_29475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3786"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="7">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="5">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="190" mass="20118" checksum="4E86B5062AE9CE58" modified="2016-06-08" version="1">MTAILGYARISTTGQDLTAQRNALAAAGVDPERVFTDELSGAVGTARPGLAALLDYARSGDTVVVAAIDRLGRSAAEVTRTIADLDKREIVLRALREGIDTATPTGRAVAAIMATLAELELELGRERRAASREARRSRSLPATKPPKLSAARQEQLCRLAATGEPVDELAAAFGIGRATAYRYLSRSRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEK0</accession>
    <name>A0A132PEK0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20753">
        <property type="protein sequence ID" value="KWX20753"/>
        <property type="gene ID" value="AFM11_28305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3535"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="70" mass="7510" checksum="3C9825614C60B2E2" modified="2016-06-08" version="1">MSHTFGPDSAVFDEDNLVSCAGLVPVMALAEQAGLTRLLDNTIHIRSSRVKSGAANPRSTDESPVRRVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF25</accession>
    <name>A0A132PF25_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855826.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10580"/>
    <dbReference type="EnsemblBacteria" id="KWX20935">
        <property type="protein sequence ID" value="KWX20935"/>
        <property type="gene ID" value="AFM11_28060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3487"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="248" mass="26099" checksum="E8D15B2524557C7F" modified="2016-06-08" version="1">MIVLLPPSETKRAGGDGPPLRLDSLSSPALTPLRETLVDELVGLAADPPACRKALGLSAAQDAEIERNAGLRRAPTMPAINRYTGVLYDALDVESLRGAAAARARARLAVGSALFGLLRADDLVPAYRLSASAKLPGRPGLSTRWRPLLEPVLAELAESELVVDLRSGSYAALGRVPGAVRVQVLAEHPDGHRTVVSHFNKAHKGHLARALVSSRAEPNDTAAVAAVARRAGMRVERHGAELTVVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFB1</accession>
    <name>A0A132PFB1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855923.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10815"/>
    <dbReference type="EnsemblBacteria" id="KWX20964">
        <property type="protein sequence ID" value="KWX20964"/>
        <property type="gene ID" value="AFM11_28265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3527"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="437" mass="46250" checksum="C7B37557C7BFD222" modified="2016-06-08" version="1">MRIVIVGAGPVGLFCAIALADRNHQIAVVDRDGGPPPHGPWVRKGVMQFHHAHTFRSQVVDALCAEMPDVLDDLVARGAEVAVGPNGQTVALLCRRSTFEYALRAAAAAHPNVVVHAGHVDRVVMENGRAVAVASGDNRLAADLIVDASGRASRFTRSLRPPAEGGDCGAVYVTRQYRLHPNAQRGPVNSPIGLSLSYPGYLAIAFLHDNGTFSVTINHDGSDPRLRGLREAGAFETSVLAIPGLGEWVDPNRSHPITPVLPGGRLYNSYRGQLDETGRPVVPGLISVGDAVCTTTPLAGRGVALGLLQARALVSAVERCGVDISSATAEFDAWCVGNIKPWFADHVAADADRIRRWSGGDVDVSRRLPSDLIVAAAAADPGLWAVIEPYAHMTALPDTLLAAEPRARQLYASGWRPDVPPGPSRDDLAAICAERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFF8</accession>
    <name>A0A132PFF8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_27275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855382.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07210"/>
    <dbReference type="EnsemblBacteria" id="KWX21078">
        <property type="protein sequence ID" value="KWX21078"/>
        <property type="gene ID" value="AFM11_27275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3330"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="30"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="324" mass="34857" checksum="29854BCFC62EFFD2" modified="2016-06-08" version="1">MTIAVTGSIATDHLMKFPGKFSEQLLADHLQKVSLSFLVDDLVIHRGGVAGNMAYAIGVLGGDVTLVGAVGKDFDDYRNWLTSHGVDCDHVLISPSAYTARFVCTTDEDMAQIASFYPGAMSEARTISLADLVAKAGKPELVIVGANDPEAMFLHTEECRKLGLAFAADPSQQLARLTGDEIRKLIDGATYLFTNDYEWDLLLQKSGWSEAEVMSQIELRVTTLGEKGVDLVGRDGTFVHVDVVPETHKDDPTGIGDAFRAGFLTGRSAGLNLERSAQLASLVAVLVLEAPGPQEWSWDRDEAVRRLSDAYGAEAGAEIARALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG45</accession>
    <name>A0A132PG45_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36230"/>
    <dbReference type="EnsemblBacteria" id="KWX21316">
        <property type="protein sequence ID" value="KWX21316"/>
        <property type="gene ID" value="AFM11_25665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2997"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="21240" checksum="82F204A4F7B7CB1C" modified="2016-06-08" version="1">MLLRHGETEWSASGRHTGRTDLDLTDTGRYQAKLAAEALAELQLQDPLVVSSPRHRALVTAELAGLTVDEIDPLLAEWDYGDYEGLTTPQIRETEPDWLVWTHGCPGGESVADVSDRADCAVALALSHMENRDVVFVGHGHFSRAMLTRWVELPVADGIRVSMVPASIAVCGFEHGVRQITALGLTAHPNPCLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG94</accession>
    <name>A0A132PG94_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25760</name>
        <name evidence="3" type="ORF">AWC31_36135</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX12043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854515.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36135"/>
    <dbReference type="EnsemblBacteria" id="KWX21333">
        <property type="protein sequence ID" value="KWX21333"/>
        <property type="gene ID" value="AFM11_25760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12043">
        <property type="protein sequence ID" value="ORX12043"/>
        <property type="gene ID" value="AWC31_36135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3016"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038424">
        <property type="entry name" value="H_kinase_PdtaS_GAF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011102">
        <property type="entry name" value="Sig_transdc_His_kinase_HWE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00911">
        <property type="entry name" value="HWE_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="298"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX12043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="499" mass="53321" checksum="37EE8829DDE998BB" modified="2016-06-08" version="1">MSTLGDLLAEHTVLPGNAVDHLHAVVGEWQLLADLSFADYLMWVRRDDGALVCVAQVRPNTAPTVLLADSVGTLAGAEDLPVVTTAFETGAIGRGSDGAQGDSYDAPGLNVEAVPVRHGGRVVAVLTHQTALAARRMASPLEGAYLDCATDLLHMLSEGTFPNVGDLAMSRSSPRVGDGFIRLDEVGDVVFASPNAISAYHRMGLASELDGHNLVTVTRPLISDPFEAQELANHVRDSLAGGSSMRMEVDAGGAAVLLRTLPLVVHGAAVGAAVLIRDVTEVKRRDRALLSKDATIREIHHRVKNNLQTVAALLRLQARRTNNVEAREALIESVRRVSSIALVHDALSMSVDEEVNLDQVVDRILPIMNDVASVDTPIRINREGDLGVLDADRATALIMVITELVQNAIEHAFDTSQPQGCVTIRAERSARWLDVVVHDDGRGLPAGFSLEKSDRLGLQIVRTLVSAELDGSLGMHDVPTGGTDVVLRVPIGRRSRGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGA6</accession>
    <name>A0A132PGA6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854634.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35870"/>
    <dbReference type="EnsemblBacteria" id="KWX21375">
        <property type="protein sequence ID" value="KWX21375"/>
        <property type="gene ID" value="AFM11_26030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3070"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015191">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09107">
        <property type="entry name" value="SelB-wing_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="559" mass="60258" checksum="9E3901F267220CF4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGC7</accession>
    <name>A0A132PGC7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26280</name>
        <name evidence="3" type="ORF">AWC31_23320</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23320"/>
    <dbReference type="EnsemblBacteria" id="KWX21267">
        <property type="protein sequence ID" value="KWX21267"/>
        <property type="gene ID" value="AFM11_26280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15708">
        <property type="protein sequence ID" value="ORX15708"/>
        <property type="gene ID" value="AWC31_23320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3123"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="147" mass="15945" checksum="813CB654E4CC339A" modified="2016-06-08" version="1">MDDLVGELFTVVGRFRRQLRRSTGGGFDGTGLTQSQGELLRLVGRRPGISVREAAAELSLVPNTASTLVSRLVADGMLVRTVDEADRRVGRLRLTPSAQRIADESRAARRAALAAVLAQLDDAQIKDLAKGLDVLTELTRLLHEKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGE0</accession>
    <name>A0A132PGE0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamine synthetase</fullName>
            <ecNumber evidence="7">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_27185</name>
        <name evidence="10" type="ORF">AWC31_07115</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855332.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07115"/>
    <dbReference type="EnsemblBacteria" id="KWX21062">
        <property type="protein sequence ID" value="KWX21062"/>
        <property type="gene ID" value="AFM11_27185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09960">
        <property type="protein sequence ID" value="ORX09960"/>
        <property type="gene ID" value="AWC31_07115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3312"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="8">
        <location>
            <begin position="105"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="4">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX21062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX09960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="478" mass="53575" checksum="BF25311487F575ED" modified="2016-06-08" version="1">MAEKTSDDIFKLIKDENVEYVDIRFCDLPGVVQHFSIPATAFDESVFEDGLAFDGSSVRGFQSIHESDMMLLPDADTARIDPFRAAKTLNLNFFVHDPFTREAYSRDPRNVARKAENYLASTGIADTAYFGAEAEFYIFDSVSFDSKINGTFYEVDSESGWWNTGEPFEADGSANRGYKVRPKGGYFPVAPYDHYVDLRDQMATNLINAGFTLERGHHEVGTAGQAEINYKFNTLLHAADDVLLFKYIIKNTAWQAGKTVTFMPKPLFGDNGSGMHAHQSLWKDGQPLFHDESGYAGLSDTARHYIGGILHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSACVRIPITGNNPKAKRLEFRCPDSSGNPYLAFAAMLMAGLDGIKKKIEPLTPVDKDLYELPPDEAASIPQAPTSLAAVIDKLEEDHEYLTEGGVFTEDLIETWISYKRENEIMPIQIRPHPYEFSLYYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGU1</accession>
    <name>A0A132PGU1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854292.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27700"/>
    <dbReference type="EnsemblBacteria" id="KWX21541">
        <property type="protein sequence ID" value="KWX21541"/>
        <property type="gene ID" value="AFM11_25380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2438"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="410" mass="42961" checksum="9515CC8001AE91B5" modified="2016-06-08" version="1">MAEPVTPPDSTRPLAGVRIIEISSFVAVPLAGMTLAQLGAEVIRVDPIGGAADYRRWPVTEHGDSIYWAGLNKGKRSVAADLRSPEGQQLVSRLIAESGVLITNVAGRQWHSYDTLSALRADLIHVEVSGRADGGTGVDYTVNAGLGFPLVTGPPQLSTPVNHVLPAWDVSCGLYVALAVSAALRHRDASGEGARISIPLENVALATAGNLGFLTEVMVNGTSRERLGNTLFGTYGQNFTSSDGVGFMLVALTGRHFRDLTEVTGTTKAVAALAEALGADFGDEGQRYLHRDALTGLFTLWFSAHTGAEITAALSGTSVLWERYRSFAEVAGDERVTANPLFRELDQPRIGRYLAPGLPVQIGGAYPPAVAAPALGDDTAAVLAEHLGLDPAEIAALTESGTVATGSAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGX4</accession>
    <name>A0A132PGX4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_23855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853454.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24290"/>
    <dbReference type="EnsemblBacteria" id="KWX21576">
        <property type="protein sequence ID" value="KWX21576"/>
        <property type="gene ID" value="AFM11_23855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2129"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="332" mass="35432" checksum="2CA2CF89BACAE3ED" modified="2016-06-08" version="1">MTTMGDVARIAGVSASTVSHVLNGTRKVNTATRLRVEAAIEETGYRRNVVARSLAAGRTHTVGLSISALTNPYFASLVHAVERALSEAGYVLIVGDSHDDVGSEKRVTDSLLDRKVDGMIVAPAAGSERVTIPEITRTGTPLVLIDRGIDIGCDQVGPENFSAARSLTEHLIELGHHQIAVVRGLSGISSTTERFDGYCTALADHGIAVDAALVLDGESNTDVAEREVRSLMSSANRPTALVSLNNAMTIGSLKAVRALGLSIPSDLAFVCYDDFEWSNLFEPRLSAAAQDVETIGAMAVELLLRRIRGEEFAPQQIRIPTTFHHRNSCGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGX8</accession>
    <name>A0A132PGX8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854085.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27215"/>
    <dbReference type="EnsemblBacteria" id="KWX21467">
        <property type="protein sequence ID" value="KWX21467"/>
        <property type="gene ID" value="AFM11_24960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2353"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="233" mass="24393" checksum="022C5F3460DDF1F4" modified="2016-06-08" version="1">MRNDSGIGVLDKAVGVLHTVAESPCGLAELCERTGLPRATAHRLAAGLETHRLLARDGDGRWRLGPALTELAAHVNDPLLAAGAAVLPRLREITGESVQLYRREGLSRVCVVALEPPAGLRDTVPVGTQLPMTAGSGAKVLLAYADAATQQAVLPTAKFTDRTLAEVRKRGWAQSAAEREPGVASVSAPVRDSRGAVIAAVSVSGPIDRMGRRPGARWAADLLAAADALTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH49</accession>
    <name>A0A132PH49_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853725.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23735"/>
    <dbReference type="EnsemblBacteria" id="KWX21660">
        <property type="protein sequence ID" value="KWX21660"/>
        <property type="gene ID" value="AFM11_24390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2238"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="193" mass="21249" checksum="C02F610E74CE9DA1" modified="2016-06-08" version="1">MARIAVILTSTRQDRFADRPAAWVAEHLHRPGVEVDVVDIRDHDLPSFDGPAPLYTPRQYATEAVAAFGRRIDAADAFIVLTGEYNHGYTGVFKNAVDHLYVEWDRKPVAFVGWGNVGGARVVEQLRTISIELGMAPIRPAVHILPDVLVPAMTAPSYDPSLFSSLDAKLDLLVSELLWWSDALTDARTESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH55</accession>
    <name>A0A132PH55_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854279.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27680"/>
    <dbReference type="EnsemblBacteria" id="KWX21537">
        <property type="protein sequence ID" value="KWX21537"/>
        <property type="gene ID" value="AFM11_25360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2434"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="336" mass="34619" checksum="7A1823B31E369754" modified="2016-06-08" version="1">MPVQLRTPELLRPTGSSRWGMAAALAFSLGAILVVTALAGHAELGSAVGLGFVLTAVPELPTTWRPGLSALCVRTLTVVVCAGIVVLCAPYEHLLGAVTVLAAVFGALVPRVGATAGLAVVLIAIDLDVGDLAGTGRLIALVPYVIGAVVVSAAWLAWFGAARLSGLAPDEEPEPRRPDLGHAARVGVAVGCAVAVAALLPADMVGGHWLVTSVLLTIQPSQGQTGMRLAQRLSGNTVGAVIAAVLLGAQPPAPVTIALTVVLFLLAMALRPVNYTWWAITGPPVLLVISEYPELFPWYEGGVRLAMNIGGALIVVLVVFAVPLLTPTLVRLRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHA3</accession>
    <name>A0A132PHA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853848.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23470"/>
    <dbReference type="EnsemblBacteria" id="KWX21701">
        <property type="protein sequence ID" value="KWX21701"/>
        <property type="gene ID" value="AFM11_24650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2291"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="175"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="275" mass="29845" checksum="D51F2E96ABC9642E" modified="2016-06-08" version="1">MTVSALSDRGLAESANITRPIIELRRGGRAPSGSYLYEGEGLITGWHSHEVHQIEYALHGVVEVETDTAHYLLPPQQAAWIPAGLEHQAVMNPDVKTVAVMFDPGLIPGGDRARIIAVSPLIREMMIYALRWPIDRADGDAVSDGFFQTLANLVAEALDHEAPLSLPTSDHPIVAAALAYTKEHLDSVTADEVSRAVSVSERTLRRLFAETLGLSWRTYLLHARMLRAMALLAAPGQSVQATATAVGFESLSAFTRCFAQFSGETPSAYRARASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHC8</accession>
    <name>A0A132PHC8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crotonyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24125"/>
    <dbReference type="EnsemblBacteria" id="KWX21713">
        <property type="protein sequence ID" value="KWX21713"/>
        <property type="gene ID" value="AFM11_24030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2165"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043880">
        <property type="term" value="F:crotonyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08246">
        <property type="entry name" value="crotonyl_coA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010085">
        <property type="entry name" value="Crot_CoA_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01751">
        <property type="entry name" value="crot-CoA-red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="35"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="417" mass="44304" checksum="29B2A7D75197E5CF" modified="2016-06-08" version="1">MSDSSIDVVDIGELPPLGVVPKKMHAEVVRPDRYGDPATAFAHEVVDTPTLGAGEVLVAVMAAGVNYNNVWAARGYPVDQVATRQRRGETEDFHIGGSDASGIVYAVGPGVDSVDIGDEVVVHPGVWDADDRWIAAGRDPMIAPSAKIWGYDTNYGSFGQFARAQAHQILPKAPHLSWAEAAAPTLVGTTAYRMLHGWAGNTIAPDDLVLVWGGSGGLGTQASQLVRAAGGRAIAVVSDDDRGAFAMKYGAIGYINRREFDHWGIPPLVDDAAGQKAWTASARAFGKRIWEIAGSRQDPAIVFEHPGGSTIPTSVFVCQPGGMVVVCAGTTGFDAMVDLRYHWTRQKRLQGSHGTNDEQAIAYNQMVVDGVIDPCVGRVLPMADIARSHAQMGRGEEVFGNTVHLVGASTPDDGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHM1</accession>
    <name>A0A132PHM1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21835">
        <property type="protein sequence ID" value="KWX21835"/>
        <property type="gene ID" value="AFM11_23610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="65" mass="7333" checksum="B78545F741482C74" modified="2016-06-08" version="1">MISLNLHIEIVKHTQNALRFVGTNILLQISFLALRILAGSLRYVFATDFCRLLASLPSSNYGIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHS8</accession>
    <name>A0A132PHS8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854234.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21562">
        <property type="protein sequence ID" value="KWX21562"/>
        <property type="gene ID" value="AFM11_25270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2416"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="221" mass="26006" checksum="15E811B113D74201" modified="2016-06-08" version="1">MKTPPIVSHAEWERARQELLVKEKQLTRARDEVVAQRRRMPWLEIERDYRFDGPDGQASLLDLFHRRRQLIVYRAFFEPGVHGWPDHACPGCSMLADQVAHLAHLNARDTTLVFASRGTQSDIARLKDRMGWAMPWYTITDTFDVDFGVDEWHGTNAFIRDGDRVFRTYFVNNRGDEAMGSTWSYLDITALGRQETWEDSPSGYPQTPPYDWWRWHDDYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHV7</accession>
    <name>A0A132PHV7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphonate metabolism protein PhnI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852667.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08950"/>
    <dbReference type="EnsemblBacteria" id="KWX21901">
        <property type="protein sequence ID" value="KWX21901"/>
        <property type="gene ID" value="AFM11_22260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1802"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019634">
        <property type="term" value="P:organic phosphonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008773">
        <property type="entry name" value="PhnI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05861">
        <property type="entry name" value="PhnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007313">
        <property type="entry name" value="PhnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="35055" checksum="80423993EB2BE4EC" modified="2016-06-08" version="1">MYASMHENPALEAARAIASAPQPRSSINLSVLAEQVCAEAGLWEPAVALRALNQSRGDTAHAVSMLRVWAATQPHADSGTVDTADVALVRRVSSAYPQVPGGQWLGFAPDLLPRQLSWSESESAIPDSPEAQPCAGDAPDRRSTPRVRDLIGGVTMVTPAEDGHSPDPAASVLAPPYTRAALLSMLSRGETGALVAMAAIVLGRRQEAVLVELTVGAAGIRMPHPRTGIGCVVAEVPITEVEVVLDADVDGRPGLAMGWGATLGTVERRAISLALLDAVMQADKELREQLTLDEQTVLAATDGSATAGFVEHLRLPHYAGFTAYLSQAAAKETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIT2</accession>
    <name>A0A132PIT2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argD</name>
        <name evidence="4" type="ORF">AFM11_22325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852687.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08885"/>
    <dbReference type="EnsemblBacteria" id="KWX21912">
        <property type="protein sequence ID" value="KWX21912"/>
        <property type="gene ID" value="AFM11_22325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1815"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="214"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="390" mass="39653" checksum="24700FA869303ECF" modified="2016-06-08" version="1">MTLQDRWEAVMMNNYGTPPLALVSGQGAVVTDADGKEYLDLLGGIAVNLLGHRHPAVIEAVTAQLNTLGHTSNLYATEPGIALAEALVGYLGTAARVFFCNSGTEANEVAFKITRLTGKTNIVAAQGAFHGRTMGSLALTGQPTKQAPFEPLPGNVTHVPYGDAAALRAAVDSDTAAVFLEPIMGEGGVVVPPAGYLVAAREITAEHGALLVLDEVQTGVGRTGSFYAHQHDGITPDIVTLAKGLGGGLPIGACLAVGPAGDLLTPGLHGSTFGGNPVCTAAALGVLKALADEDLIARAGVLGKTLSHGIEELDHPLVGQVRGKGMLQGIVLTAPSAKAVESAARDAGFLVNAAAPDVVRLAPPLVITDGQIESFLTALPAVLDTAVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJH0</accession>
    <name>A0A132PJH0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_19870</name>
        <name evidence="11" type="ORF">AWC31_28645</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000016">
        <property type="protein sequence ID" value="ORX14068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851856.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28645"/>
    <dbReference type="EnsemblBacteria" id="KWX22414">
        <property type="protein sequence ID" value="KWX22414"/>
        <property type="gene ID" value="AFM11_19870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14068">
        <property type="protein sequence ID" value="ORX14068"/>
        <property type="gene ID" value="AWC31_28645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1308"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006469">
        <property type="entry name" value="NifC_ABC_porter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01581">
        <property type="entry name" value="Mo_ABC_porter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="51"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX14068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="264" mass="27432" checksum="7987753E09E96C45" modified="2016-06-08" version="1">MRTSPGLPRWIYLPAALGAAFVVLPLVAMAARVDWPRFWTLISSDTSTAALVLSLKTAAASTVLCLLLGVPLALVLARNDGRLVRLTRPLILLPLVLPPVVGGIALLYAFGRLGLIGRYLEAAGVQIAFTTAAVVLAQTFVSLPFLVISLEGAARTAGSDYEVVAATLGARPGSVWWRVTLPLLGPGLVSGAVLAFARALGEFGATLTFAGSRAGVTRTLPLEVYLQRESDADAAVALSVLLVAVAAVVVIGLGSRRLRAGGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJL6</accession>
    <name>A0A132PJL6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22521">
        <property type="protein sequence ID" value="KWX22521"/>
        <property type="gene ID" value="AFM11_20475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="109" mass="12089" checksum="C851F18D9E0C7D58" modified="2016-06-08" version="1">MSAARRAGLTGQQIEAIAWGFLHSEFTGQIYAIWPMDRRIDAYLLRRGMRAIINDGSAYNRLTERVMANMGRALRAGPVKPSGGHRDGYPQGARRPGSSAEPHRVRPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJQ3</accession>
    <name>A0A132PJQ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">General stress protein CsbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_18795</name>
        <name evidence="5" type="ORF">AWC31_14885</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851523.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_14885"/>
    <dbReference type="EnsemblBacteria" id="KWX22566">
        <property type="protein sequence ID" value="KWX22566"/>
        <property type="gene ID" value="AFM11_18795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17726">
        <property type="protein sequence ID" value="ORX17726"/>
        <property type="gene ID" value="AWC31_14885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1094"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX17726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="57" mass="6108" checksum="93CBF56539FB50EE" modified="2016-06-08" version="1">MGTNDKISNKLDDVAGKAKEGVGRATGDRDTENEGKLDQAKSNLKDAGEKIKDAFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJS5</accession>
    <name>A0A132PJS5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_18925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851565.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15015"/>
    <dbReference type="EnsemblBacteria" id="KWX22585">
        <property type="protein sequence ID" value="KWX22585"/>
        <property type="gene ID" value="AFM11_18925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1119"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="149" mass="15411" checksum="6D000DCBF1159B6E" modified="2016-06-08" version="1">MTAWRDWAPLPLRVFLGGGLILHGGIKLFVPGGHANIAHLVGQLGVPFADFLGWVVGVVEFGGGLGILLGVFFRVATVVNALNVGGLLVLGFIAGGIPEPLPGGDPLPEFREALLILAGVLSLLLSGPGRLALDTKLGGHKKLLTSENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJZ0</accession>
    <name>A0A132PJZ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851697.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15420"/>
    <dbReference type="EnsemblBacteria" id="KWX22651">
        <property type="protein sequence ID" value="KWX22651"/>
        <property type="gene ID" value="AFM11_19335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1200"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="347" mass="39302" checksum="7C56A5C49156E8CA" modified="2016-06-08" version="1">MRFSLFVHMERWDESVSHRELFENLTELSLMAEAGGFSTVWIGEHHAMEYTISPSPMPLLAYLAGQTTTIRLGAGTIIAPFWNPIRAAGECALLDVISNGRMEVGLARGAYQIEFDRMMPGLPASEGGKYLRELVPAVRKLWQGDYAHDGDIWQFPASTSVPKPVQQPMPPMWIAARDPDSHDFAVAQGCNVMVTPLMKGDEEVVDLKRKFDTAVENHPEVARPQLMVLRHTHVHAAEDPDGWRPAAEAISKFYRTFDAWFGNKTTPVNGFLEPSPESKFAERPEFELESLHRTAMIGTPEEVIERLRFYQELGVDEFSFWCDNSLPHDEKRKSLELFIKEVVPAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKB2</accession>
    <name>A0A132PKB2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_20115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851904.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29995"/>
    <dbReference type="EnsemblBacteria" id="KWX22462">
        <property type="protein sequence ID" value="KWX22462"/>
        <property type="gene ID" value="AFM11_20115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1359"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="111" mass="11447" checksum="0F670AF1C1CAA2A0" modified="2016-06-08" version="1">MRKWALLGAAIGTEVTATLSLRASQDHAAWLVLVVAGYLSSFLLLTLVLRAGMAVGVAYGIWGAMGTATTAVLAAVLFGDPFTWPIVAGIGLIIAGVLLVELGSHPREAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKN9</accession>
    <name>A0A132PKN9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851300.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12295"/>
    <dbReference type="EnsemblBacteria" id="KWX22863">
        <property type="protein sequence ID" value="KWX22863"/>
        <property type="gene ID" value="AFM11_18225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1002"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="32453" checksum="3F01AD0CF3D942DD" modified="2016-06-08" version="1">MALSARMPELAAFEVLLAIARTGSLGAAGRQLGLTQQAVSSRLASIEAQTGVQLVRRSTRGSQLTPAGVVVAEWADQLLDVAQRVDAGLAAMRTESHNRLTVAASLTIAEQLMPRWLVSLQADAQRRGIRAPEVILTAANSDQVIAAVRDGSAELGFIESPGTPKGLHSRVVARDELVVVVPPNHKWTRRSAVGAEEINGTPLVSREVGSGTRDALSTALRAALGDGAQQADPAIELSSAAAMRAAVLAGAGPAVMSRLAVEDDLTLGRLRAVPVAELDLRRELRAIWLGGRTPPAGAVRDLLSHIAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKW2</accession>
    <name>A0A132PKW2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_16505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850646.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22978">
        <property type="protein sequence ID" value="KWX22978"/>
        <property type="gene ID" value="AFM11_16505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.650"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025159">
        <property type="entry name" value="AbiEi_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13338">
        <property type="entry name" value="AbiEi_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="311" mass="35063" checksum="EB7F34B097545939" modified="2016-06-08" version="1">MVFDDVLRQQDGVISRRQALDAGLQEHDVRRLLRRKEWARVHPGVYVNHTGPLTWLQRAWAAVLYAAPAALCFESALGDESSPIHVAVTRQRALLAEPAGVRIHHLAHLDERVLWNVRPPRIRYDEAVLDVACRAARELDAIAVLANACQSRRTTARRLLQALDSRERVRRRGWLRAVLVDISEGTCSVLEHGYLVRVERPHCLPRATRQKRSATSVGVCYRDAEYSERLVIELDGRVYHDSATRRDADFERDLDAAVDGRSTVRLSYGQVFDRPCQTAWKVAQVLQRHGIVVPGQSCGPRCGFAGFDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKX1</accession>
    <name>A0A132PKX1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ald_Xan_dh_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850671.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22988">
        <property type="protein sequence ID" value="KWX22988"/>
        <property type="gene ID" value="AFM11_16570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.663"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="795" mass="84884" checksum="99A3D1D88EC46B67" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL93</accession>
    <name>A0A132PL93_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_16380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850607.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19940"/>
    <dbReference type="EnsemblBacteria" id="KWX22957">
        <property type="protein sequence ID" value="KWX22957"/>
        <property type="gene ID" value="AFM11_16380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.624"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="380" mass="42086" checksum="B0CBF8CE6A3DFA43" modified="2016-06-08" version="1">MKRQIYTAEHEAFRETVKEYIERELVPHSEKWEAERIVDRSAYTAAGKYGVIGFNMPEEFGGGGSDDFRFNAIIDEEVAKSGVHGPALSLHNDVVGPYFKELANDEQKKRWLPGIASGELIIAIAMTEPGAGSDLAGIRTSAVRDGDDWIVNGSKTFISSGINCDLCVVVARTDPEAGHKGFTLLVVERGMEGFSRGRKLDKMGLHSQDTSELHFENVRVPNANVLGKEGRGFYHLMTNLPSERLSIAISAIAGARAVWQETLQYAKDRKAFGQPIGSFQHNRFLLAEMETELEVTETYIDRCLQAVVDGELTAVEAAKAKWWATEVAKKVVDNCVQLHGGYGYMMEYRVARAYVDGRIQTIFGGTTEIMKEIIGRDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLK3</accession>
    <name>A0A132PLK3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_17025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850836.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01595"/>
    <dbReference type="EnsemblBacteria" id="KWX23067">
        <property type="protein sequence ID" value="KWX23067"/>
        <property type="gene ID" value="AFM11_17025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.758"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="90"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="189"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="254" mass="28802" checksum="2E6268FAA8892A34" modified="2016-06-08" version="1">MEHGGRRRTARRDRNNELVSRVEQSEICEQEDLATIASQQITTAQPAPVSMAHLEQFTEGDWVEPSDELTGTAVFDATGDKAAMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVFRSVQNYQPGTFEGWLHRITTNLFLDMVRRRGRIRMEALPEDYDRVPADDPNPEQIYHDSRLGADLQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVRSRIHRGRQALRDYLAKHSPETAQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLS2</accession>
    <name>A0A132PLS2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850987.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02010"/>
    <dbReference type="EnsemblBacteria" id="KWX23137">
        <property type="protein sequence ID" value="KWX23137"/>
        <property type="gene ID" value="AFM11_17425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.839"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="168" mass="17759" checksum="56FA6BA893D9186B" modified="2016-06-08" version="1">MTTRTLLLLRHAKSDYPDGVVDHDRPLAQRGVREGALAGDWIRANAPKVDAVLCSTATRTRETLARTGIDAPVEYVERLYDATPGTVIGEINAVQSHFGTEPATVLVIGHEPAMSAVALGLSDGTNAAAAENISLKFPTSAIAVLRPAGPWEDLALGGAELVTFHVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLY0</accession>
    <name>A0A132PLY0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850525.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16885"/>
    <dbReference type="EnsemblBacteria" id="KWX23358">
        <property type="protein sequence ID" value="KWX23358"/>
        <property type="gene ID" value="AFM11_16255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7376"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="267" mass="28065" checksum="543156BE8F91CBFF" modified="2016-06-08" version="1">MTRRVAGKRVLITGAARGMGRSHAVRLAEEGADLILVDICRSLDEIEYPLSSREDLDETARLVEKQGRQAVTHVVDVRDGAALAAAVDDGVARLGGLDAAVANAGVLTAGTWDTTTAEQWRTVVDVNLIGTWNTCAAALPHLIEGGGSLVNISSAAGIKGTPLHTPYTASKHGVVGMSRALANELAAQHVRVNTVHPTGVETGMRPASLHTLIAEQRPDLAPLFGNAIPIVMAEAIDISNAVLFLVSDESRYVTGLEFKVDAGVTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMD1</accession>
    <name>A0A132PMD1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849866.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23496">
        <property type="protein sequence ID" value="KWX23496"/>
        <property type="gene ID" value="AFM11_14555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7020"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="30318" checksum="C77DDF3620E3958C" modified="2016-06-08" version="1">MTGSRLRTFVWNVRYHPKRELWFAWYVMVFFYQLYGVLFFFVTRVQPPPSPAWDTPTVVDWVTGHRFGVLAGFAIVFLITGLCAPMNALLAYSMRRMSVNPAFAYSYLIMYSLSAIPGMLIMAIAMTAAALRTDRDPEIIHWLYEFAFLSFSGTMGVFLIGSLVWMTAVLLDKNRVFPKWFGYLNLCNALTEVVVAPAWIFQRGAFAWNGAIAWWVNMVVFVTYTGVFIVLLRRMIEREDFGTGPLPDLPDPQADEQQIAVEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMI5</accession>
    <name>A0A132PMI5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_14900</name>
        <name evidence="3" type="ORF">AWC31_18000</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849980.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18000"/>
    <dbReference type="EnsemblBacteria" id="KWX23549">
        <property type="protein sequence ID" value="KWX23549"/>
        <property type="gene ID" value="AFM11_14900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17216">
        <property type="protein sequence ID" value="ORX17216"/>
        <property type="gene ID" value="AWC31_18000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7091"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="161" mass="17530" checksum="F6CC7A3067B83A37" modified="2016-06-08" version="1">MVETESQVTELAGELQRVLSKVFSVLRRGDTHKGTAGDLTLAQLSILLTLLDQGPIRMTELAARERVRTPTTTVAIRRLEKLGLVKRSRDPSDLRAVLVDVTPRGLVQHRESLAARRADLAARLAKLSSEDLETLAKALAPLERLAGQEEESAASSAKADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PML0</accession>
    <name>A0A132PML0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849992.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17965"/>
    <dbReference type="EnsemblBacteria" id="KWX23555">
        <property type="protein sequence ID" value="KWX23555"/>
        <property type="gene ID" value="AFM11_14935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7098"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="854"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="918" mass="97907" checksum="E0EABD5EAE4E28F8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMX1</accession>
    <name>A0A132PMX1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="14" type="ORF">AFM11_14885</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849976.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18015"/>
    <dbReference type="EnsemblBacteria" id="KWX23547">
        <property type="protein sequence ID" value="KWX23547"/>
        <property type="gene ID" value="AFM11_14885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7088"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="12">
        <location>
            <begin position="66"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="13">
        <location>
            <begin position="298"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="803"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="725"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="728"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX23547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="953" mass="105929" checksum="07C97DE0127DD58B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMZ2</accession>
    <name>A0A132PMZ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,3-dihydroxybiphenyl 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848964.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02830"/>
    <dbReference type="EnsemblBacteria" id="KWX23634">
        <property type="protein sequence ID" value="KWX23634"/>
        <property type="gene ID" value="AFM11_12570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6604"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="177"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="373" mass="41113" checksum="F838068077163B12" modified="2016-06-08" version="1">MSDGHRYLHSERGALAGEHSGRARDPIIRVADIAWLEFDKPDLVRAEAFARAFGFGVALRDPQELHLRGTTAGSPCVILRRGQHSRFTGLALRAADEVDLLRLADKTGARLQPLPESIGGTAVRLTDPSGIAVKVVAGLHTLPAQTEQTPQVRNTGIADSRINATVRPPRVPARVQRLGHVVLQSTTYLRTLNWYLETFGMIVSDFLFFPGQRDRGPAMSFIRCDRGATPADHHTLALALGPTNRYVHSAYEVSDLDALAAGGEYLSERGYFRSWGIGRHIQGSQLFDYWRDPDGFLVEHFADGDMFDNTVEPGWAPFTASGLAQWGPPVTKDFLDATPRAARHQVTSMLSALRDNNEFDLDRLVGLLKVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN10</accession>
    <name>A0A132PN10_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13015</name>
        <name evidence="3" type="ORF">AWC31_03300</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849183.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03300"/>
    <dbReference type="EnsemblBacteria" id="KWX23705">
        <property type="protein sequence ID" value="KWX23705"/>
        <property type="gene ID" value="AFM11_13015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11164">
        <property type="protein sequence ID" value="ORX11164"/>
        <property type="gene ID" value="AWC31_03300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6696"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="281" mass="30456" checksum="3E43F3B08A025EC9" modified="2016-06-08" version="1">MRPAIKVGLSTASVYPLRTEAAFEYAARLGYDGVELMVWAESVSQDVEAVAAMSARYGVPVLSVHAPCLLISQRVWGANPIPKLERSVRAAEQLGAQTVVVHPPFRWQRRYAEGFTEQVASLEADSDVLVAVENMFPFRADRFYGAGQTSIERMRKRGGRPGPGISAFAPSYDPLDGNHAHYTLDLSHTATAGTDALDMARRMGDGLVHLHLCDGNGASTDEHLVPGRGTQPTAEVCQMLATGNFAGHVILEVTTSGARTASEREALLTESLQFARKHLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN53</accession>
    <name>A0A132PN53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_13355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849346.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03640"/>
    <dbReference type="EnsemblBacteria" id="KWX23760">
        <property type="protein sequence ID" value="KWX23760"/>
        <property type="gene ID" value="AFM11_13355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6765"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="29051" checksum="229FDC43E9F3CD5D" modified="2016-06-08" version="1">MAIGGVLFDIDGVLVTSWQPIDGAAETLRVLEDNQIARSYLTNTTTRTRAQIAELLTAAGMAVAADEVITAAVLTAEYVRDRYPDARCFLVNSGQIGEDMPGVDVVYSSDFTGPQAPDTPDVVLLGGAGPEYSHLTLSWVYDWMAQGVPVVAMHRSTAWNTTDGLRVDTGMYLIGMEETSGRKATAVGKPAPEGFVAAANRLGVDPDEMYMIGDDLNNDVLAAQVVGMTGVLVRTGKFRQSTLDRWAADEFAMQPNFVIDSVADLPELLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNH6</accession>
    <name>A0A132PNH6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_12860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849568.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03145"/>
    <dbReference type="EnsemblBacteria" id="KWX23865">
        <property type="protein sequence ID" value="KWX23865"/>
        <property type="gene ID" value="AFM11_12860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6664"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="PTHR30028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="280" mass="28415" checksum="2BE691975324A2D0" modified="2016-06-08" version="1">MLLDEPTLGAPLIVLCLGMAIAAALIYRLAGLGPPATVPWATLRAGVQLAAVAAILAAAITQLWSSVLVLAVMFTVASLTAARRSQATRGSAWIAMALAAGLLCVLPALLLSGVVPSTGVAVVPIVAIVLGGTMTAVAVAARLALDTLVLRAGEVEAALSLGMSNRDSRLEVIRGAATNALLPNLDSTRTVGLVTLPGAFVGVLLSTGSAAQAGAVQILVLVALLLSQSCAVAITIELIARGRIVRAQNPSPQAGRRRIFGVGSVWSRWGHGTSMGTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNV0</accession>
    <name>A0A132PNV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-oxalomesaconate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848294.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23995">
        <property type="protein sequence ID" value="KWX23995"/>
        <property type="gene ID" value="AFM11_11540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6384"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="352" mass="38927" checksum="4478EE81C5F55EF7" modified="2016-06-08" version="1">MIIDCHGHFTTAPRALGMWRERQIKAFEDSGARVSPDELNITDDEITSAIENGQLKLQVERGTDLTLFSPGAGKMAHHYGDAQTSLVWSQVSNDLIARVCGLFPGRFVGVCQLPQSPGDALASSIRRSAVELERCVAEHGFVGCLLNPDPSDGYWQAPPLTDRIYYPLYEKMVELDVPAMIHVAMSRNPAIQGTCAHYLNGDTAVFMQLCQSDLFTDFPTLRFILPHGGGAVPYHWGRYRGVMLDQGRPSLQEALLHNVFFDTCVYHKRGLELLTDIIPAENVLFASEMIGAVRSVDPETGHRFDDTKALLDSIDTISDDDRQAIYGGNALRVFPRLAAHIAKQDDLKGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP18</accession>
    <name>A0A132PP18_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_12040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848568.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09935"/>
    <dbReference type="EnsemblBacteria" id="KWX24086">
        <property type="protein sequence ID" value="KWX24086"/>
        <property type="gene ID" value="AFM11_12040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6487"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03914">
        <property type="entry name" value="UDG_fam_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="38"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="214" mass="23001" checksum="2A9E4DBEDFAA4AD9" modified="2016-06-08" version="1">MAGAEVFVPDSRDLEVLTTAARGCRGCDLYRDASQTVFGAGARDARMMLIGEQPGDREDRAGAPFVGPAGRVLDDALHAAGIERDSVYLTNAVKHFKFTQAERGKRRIHKTPSRTEVVACRPWLVAELDAVEPEVVVLLGATAAKSVLGNDFRVTQHRGEVLHLPSGVTTGEPELVATVHPSSLLRGPKEDRDIAFDGLVDDLRLAASLCHTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP33</accession>
    <name>A0A132PP33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12125</name>
        <name evidence="3" type="ORF">AWC31_09850</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09850"/>
    <dbReference type="EnsemblBacteria" id="KWX24099">
        <property type="protein sequence ID" value="KWX24099"/>
        <property type="gene ID" value="AFM11_12125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09237">
        <property type="protein sequence ID" value="ORX09237"/>
        <property type="gene ID" value="AWC31_09850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6504"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="30"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="236" mass="25404" checksum="99FAB13305216608" modified="2016-06-08" version="1">MTVSPDIEQGLSQDVSPADTSARTGVRRVLLVWDAPNLDMGLGSILGGRPTAAHRPRFDALGRWLLAYTADLSAASAAEGEPTISLEPEATVFTNIAPGSADVVRPWVEALRNVGFAVFAKPKIDDDSDVDSDMLNHIALRRSEGLAAVLVASADGQAFREPLEEIAREGTPVQVLGFREHASWALASDTLEFVDLEDIPGVFREPLPRIGLDSLPEQGAWLQPFRPLSSLLTSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPC2</accession>
    <name>A0A132PPC2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848572.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09925"/>
    <dbReference type="EnsemblBacteria" id="KWX24180">
        <property type="protein sequence ID" value="KWX24180"/>
        <property type="gene ID" value="AFM11_12050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6489"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="241" mass="24238" checksum="4F2D40136C8FA05B" modified="2016-06-08" version="1">MGRTVVVTGGGTGIGRAIAQRFAVSGDSVVITGRRKAVLEETTATLPGNVVSACFDATDPDAVGGFVETLGAVDVLVNNAGGNRDFDAASPGQTLREVADAWLSNFAANVLSAVIMTTACRDKLASGGAVITLGSIAADQGSGSYGAAKAAVASWNIELSRALGPLGVTANVVSPGYIADTEFFRDKLSGQRTSELIAATATGRAGTPQDIAATVEFLASPAARHLTGQVLAVNGGAWATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPJ2</accession>
    <name>A0A132PPJ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxoglutarate ferredoxin oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_09660</name>
        <name evidence="6" type="ORF">AWC31_05565</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847227.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05565"/>
    <dbReference type="EnsemblBacteria" id="KWX24251">
        <property type="protein sequence ID" value="KWX24251"/>
        <property type="gene ID" value="AFM11_09660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09696">
        <property type="protein sequence ID" value="ORX09696"/>
        <property type="gene ID" value="AWC31_05565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5970"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="27"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="3">
        <location>
            <begin position="265"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="4">
        <location>
            <begin position="516"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="646" mass="68789" checksum="C1AA6D209722DE0E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPK4</accession>
    <name>A0A132PPK4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847297.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05430"/>
    <dbReference type="EnsemblBacteria" id="KWX24276">
        <property type="protein sequence ID" value="KWX24276"/>
        <property type="gene ID" value="AFM11_09795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5997"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="210" mass="21356" checksum="9F58BF1700E72BEF" modified="2016-06-08" version="1">MMTLTFVTGALDAVGYLGLDRIFTGNMTGNIVILGMGVAAEDDLPVVGPLLALGAYVAGAALAGRILREYSGVWPPAVTKLLLGSAGILTAVGVAMAVWDIAGAGPGGIVCAGTIALLMGAQAATARVLAVTDMTTVVVTSTITAYASETLFTPGWAWLKHRRLWAILAIFAGALTGALMMKIHISIPVFTAAAATAAVAVIGHHGWLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPN6</accession>
    <name>A0A132PPN6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30540"/>
    <dbReference type="EnsemblBacteria" id="KWX24167">
        <property type="protein sequence ID" value="KWX24167"/>
        <property type="gene ID" value="AFM11_11355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6348"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_3" evidence="1">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="99" mass="10945" checksum="E0CF31B06B04B021" modified="2016-06-08" version="1">MEDWGPLPEATGEPMATAGKKLWTGDGIREFGIWKCAPGPSRWVFETHESITVLSGRMTVTEDGGEPYEVKAGDSAVFPKGWTGNWDIHDTILKVYTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPS9</accession>
    <name>A0A132PPS9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847507.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24341">
        <property type="protein sequence ID" value="KWX24341"/>
        <property type="gene ID" value="AFM11_10195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6077"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="127" mass="13196" checksum="EB488C461EBC9993" modified="2016-06-08" version="1">MLDTRPDVDAPERTPWHESDWAMVVAGIGGLLVIGALAFAVFMTSHQSTLPVLPHETTTSTLTTASTTRHPLSSSATRPVPVTTSELTQPAIVPPAPEESPVSTSEAATTTMTNPYATTTVANAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ19</accession>
    <name>A0A132PQ19_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_10845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847834.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19360"/>
    <dbReference type="EnsemblBacteria" id="KWX24446">
        <property type="protein sequence ID" value="KWX24446"/>
        <property type="gene ID" value="AFM11_10845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6208"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="158"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="378" mass="40492" checksum="BA6A53903CFF94E4" modified="2016-06-08" version="1">MGIDIQADGRALRVSRRERAIAQMEAYDLDVLVLGRQANVRYISGAPQLWVVGTRPFGPICTFVRATGEIHLNSTWDEGIPEEIPHENLYGLAWNPMTLIGVLQNIKGTDTARRVGTDALTPTFAKLLPMAFPQAELVDGEQAMRDARRIKTPEEIEALRRALRVAEEGLAKASAELTDGTTEQSLAGVLLEAEAAGGVSTPATQDAAWVTSKEHPWRRADGDGTVRDGDLVALSAGVLADGYVGEVARTHYVGEPTDAVRALYRRRDELWDRLLDVCRAGTTTSALLDAYQQAGERLPAMPVAHGLGLGFDPPVVSPDLRATAERDALEDGMVLAVTAYVWEPGVGAVFTRDAVVIGSDGPQVLTHTPSVSGAVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ75</accession>
    <name>A0A132PQ75_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847942.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18705"/>
    <dbReference type="EnsemblBacteria" id="KWX24488">
        <property type="protein sequence ID" value="KWX24488"/>
        <property type="gene ID" value="AFM11_10260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6090"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="251" mass="26474" checksum="7823FFF584054C51" modified="2016-06-08" version="1">MTDSPRRDGSEPTQQLGSGYPVDYPDPAYANQPPYNGVYPAAPNTTRQLPSYPPYGYDPYATGQYGTGYPPPGEPPQEQEPDGREPRMWLWVLAALAVLIVVGLVIALVIANGSRQETVVAPPIAPEPSFSTPSTTPTTTSRAPRPIPVPPPTTAPTGTTTPGATETVTYEVAGEGRAINITYLDTGNMFQTEFNVLLPWSKTVELAEPAGETASVSVLNFGPEVSCTVSVNGVQTQHRTGSGLTICVGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQC7</accession>
    <name>A0A132PQC7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconolaconase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846009.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22065"/>
    <dbReference type="EnsemblBacteria" id="KWX24536">
        <property type="protein sequence ID" value="KWX24536"/>
        <property type="gene ID" value="AFM11_07565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5361"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="32"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="527" mass="54419" checksum="14CAE0D8AA683B91" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQQ5</accession>
    <name>A0A132PQQ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07570</name>
        <name evidence="3" type="ORF">AWC31_22070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846012.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22070"/>
    <dbReference type="EnsemblBacteria" id="KWX24537">
        <property type="protein sequence ID" value="KWX24537"/>
        <property type="gene ID" value="AFM11_07570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16700">
        <property type="protein sequence ID" value="ORX16700"/>
        <property type="gene ID" value="AWC31_22070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5362"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX16700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="245" mass="27382" checksum="02D1C33B584E610D" modified="2016-06-08" version="1">MTVTPAEHRYLQVARTLRKEIVDGVYPVGSQLPTEHELCERFEVSRYTIREALRRLRDDNLVSSRPRAGTLVVPRAATNSYAQDVMSINDLLAFATGAQFTIESNAMVTIDDELAERTGLPVGQQWLAVRGYRQADGDAPPVCRTEYYINRSFAAVGRLLQRHTGPIFPLIEDLFGVSIVEVHQEITAVLVDAELAELLKVEPGSAALQMQRTYTTSDGEVAQVTINTHPSDRFRHAMTMRRVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQQ6</accession>
    <name>A0A132PQQ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-keto-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_08310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846397.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00200"/>
    <dbReference type="EnsemblBacteria" id="KWX24668">
        <property type="protein sequence ID" value="KWX24668"/>
        <property type="gene ID" value="AFM11_08310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5513"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="TPP_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PTHR43452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="201"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="399"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX24668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="560" mass="59200" checksum="17FC570DC459E066" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR51</accession>
    <name>A0A132PR51_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_09125</name>
        <name evidence="2" type="ORF">AWC31_13245</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846802.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13245"/>
    <dbReference type="EnsemblBacteria" id="KWX24803">
        <property type="protein sequence ID" value="KWX24803"/>
        <property type="gene ID" value="AFM11_09125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18287">
        <property type="protein sequence ID" value="ORX18287"/>
        <property type="gene ID" value="AWC31_13245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5674"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="356" mass="37787" checksum="7D93B7B81BA6D9E9" modified="2016-06-08" version="1">MTSGSNRQVAVVGFAHAPHVRRTDGTTNGVEMLMPCFHQLYEELGLQQTDIGFWCSGSSDYLAGRAFSFISAIDSIGAVPPINESHVEMDAAWALYEAYIKILTGEVETALVYGFGKSSAGILRRVLSLQTDPYTVAPLWPDAVSMAGLQARFGLDAGKWTAEEMAQVALDSFAVSERTDSEKPAKTIEELLDRPFFADPLRRHDIAPIADGASAIVLAAGDRARELRENPAWITGFEHRIETPVLGARDLTTSPSTAASAQAATGGDTGSIEVAELYAPFTHQQLILTEAIGLGESTKINPSGGVLAANPMFSAGLERIGFAAQHIFDGSAGRVLAHATSGAALQQNLVAVLEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRD9</accession>
    <name>A0A132PRD9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urea ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Urea ABC transporter ATP-binding subunit UrtE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_05500</name>
        <name evidence="6" type="ORF">AWC31_12875</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845002.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12875"/>
    <dbReference type="EnsemblBacteria" id="KWX24899">
        <property type="protein sequence ID" value="KWX24899"/>
        <property type="gene ID" value="AFM11_05500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18847">
        <property type="protein sequence ID" value="ORX18847"/>
        <property type="gene ID" value="AWC31_12875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4290"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017780">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03410">
        <property type="entry name" value="urea_trans_UrtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX18847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="230" mass="24173" checksum="87FFCC13C4EF6349" modified="2016-06-08" version="1">MLELVDVRTGYGRSEVIHGASIEVPSDGVAAVMGHNGAGKTTLLRAAVGLLKCTAGKVLFEGEDITKLRPSARVARGLAYVPQGQQSFGQLTTAENLQVVADGRKNGKALIDEQLDLFPALKELLTRRAGLLSGGQRQQLAIARALITSPKTLILDEPTEGIQPSVVAEIEQAITALTARGDLGVLLVEQHIGFALESSQRYYILESGRITSSGTGGSASEADVRAAMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRG1</accession>
    <name>A0A132PRG1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845068.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13065"/>
    <dbReference type="EnsemblBacteria" id="KWX24931">
        <property type="protein sequence ID" value="KWX24931"/>
        <property type="gene ID" value="AFM11_05685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4328"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013589">
        <property type="entry name" value="Bac_transglu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08379">
        <property type="entry name" value="Bact_transglu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="184"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="306" mass="33299" checksum="7D985C6ED2622287" modified="2016-06-08" version="1">MTVANTGAATRCYEITHRTVYRYSDDVTSSYGRGFLTPRDLPWQRCLAHELLIDPEAADSSTSRDGYGNLSSYFHVTERHRTLSITSHSVVEVDPPAPDQYTGASAKAPWELARPVGADGALAAEFTMDLQPPEITDAVRDYAAPSFDPGRPLIEVLGDLTSRIFTDFTYRSGSTTVSTQVAEVLQAREGVCQDFARLAIACLRANGLAASYVSGYLATDPPPGKERMIGVDATHAWASVWTPQNQWLALDPTNDQMVDERYIVAGFGRDYADVPPLRGIIYTDSDSSAIEVAVDVAPYEGGLLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRG7</accession>
    <name>A0A132PRG7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_05655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845058.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13030"/>
    <dbReference type="EnsemblBacteria" id="KWX24926">
        <property type="protein sequence ID" value="KWX24926"/>
        <property type="gene ID" value="AFM11_05655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4321"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="272"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="394" mass="40603" checksum="87D2413FBB1FEE6D" modified="2016-06-08" version="1">MTGYAGRDAVIVGAVRTPIGKGKANGALHGVLPADLLAHSLRELIARTGVDPVHVDDVIAGAVTQVGDQAVNIARNALLGAGFPETVPGTTVDRQCGSSQQAISFAAQGVLAGAYDIVIAAGVESMSRVPMGTSVLPGSDPFGLDMAARYPDGLVPQGISAELIAAKWKLSRTQLDEFSAASHEKAARATKDGLFEAELAPIAGLTTDEIIRPGTSVETLAGLKPAFYTEAYATRFPQINWEITPGNSSPLSDGSAAVMITSGETAKRLGLRPLARIHTTTVVGSDPLYMLTGVIPATEKVLARAGLTLSDIDLFEVNEAFAPVVLAWAANTGADLAKTNVNGGAIAIGHPLGASGARIMTTLVNALEQRGARYGLQTMCEGGGMANATIVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRM7</accession>
    <name>A0A132PRM7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845163.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24983">
        <property type="protein sequence ID" value="KWX24983"/>
        <property type="gene ID" value="AFM11_05990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4389"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018702">
        <property type="entry name" value="DUF2207_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09972">
        <property type="entry name" value="DUF2207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="606" mass="65008" checksum="A54CBE074527DB6B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRX4</accession>
    <name>A0A132PRX4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="3 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroK</name>
        <name evidence="12" type="ORF">AFM11_05790</name>
        <name evidence="13" type="ORF">AWC31_11650</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="3 10"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000002">
        <property type="protein sequence ID" value="ORX19218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845099.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11650"/>
    <dbReference type="EnsemblBacteria" id="KWX24947">
        <property type="protein sequence ID" value="KWX24947"/>
        <property type="gene ID" value="AFM11_05790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19218">
        <property type="protein sequence ID" value="ORX19218"/>
        <property type="gene ID" value="AWC31_11650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4349"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="162"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX24947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX19218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="226" mass="24282" checksum="CA8EF251683BFF82" modified="2016-06-08" version="1">MAPKAVLIGLPGSGKSTIGRRLAKALDLTMLDTDAAIEETTGRTIADIFANDGEREFRRIEEEVVRSALETHDGVLSLGGGAVTTPGVREALAGHTVIYLEISAAEGVRRTGGTTVRPLLAGGDRAEKFRALMSQRVPIYRRVATMRINTNRRNPGAVVRTIVSRLENPQPPKTAASKPRRRRRPPWRRGPASDGDGKAGSNGTAKNKPMPTPAALAARNAERHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSD1</accession>
    <name>A0A132PSD1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transketolase</fullName>
            <ecNumber evidence="3 8">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_06255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845840.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29420"/>
    <dbReference type="EnsemblBacteria" id="KWX25249">
        <property type="protein sequence ID" value="KWX25249"/>
        <property type="gene ID" value="AFM11_06255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4444"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="9">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="696" mass="75450" checksum="FDB805B243A93832" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSG6</accession>
    <name>A0A132PSG6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoadipate CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843856.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25298">
        <property type="protein sequence ID" value="KWX25298"/>
        <property type="gene ID" value="AFM11_03125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2496"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="218" mass="22792" checksum="B6B0CCD71D0E1BF5" modified="2016-06-08" version="1">MVTMCDTTAQAVADITDGSTVLIGGFGMAGMPVALIDALIDHGATELTVVSNNAGNGDTGLAALLAAGRVRKVICSFPRQSDSWVFDELYRGGRIELEVVPQGTLAERMRAAGAGIGAFYCPTGVGTLLAAGKETRHIDGRTYILEYPLSGDFALIGAYTADRIGNLLYRKTARNFGPVMATAAATTIVQVHNIVDTGALDPEAVVTPSIYVDKVVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSU6</accession>
    <name>A0A132PSU6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="10" type="ORF">AFM11_06690</name>
        <name evidence="11" type="ORF">AWC31_28985</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845391.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28985"/>
    <dbReference type="EnsemblBacteria" id="KWX25102">
        <property type="protein sequence ID" value="KWX25102"/>
        <property type="gene ID" value="AFM11_06690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13823">
        <property type="protein sequence ID" value="ORX13823"/>
        <property type="gene ID" value="AWC31_28985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4537"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX13823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="223" mass="23457" checksum="9E36D306AFF88E1D" modified="2016-06-08" version="1">MTDETSGPAEPVTDAPGDAESPAPPRRRLRLLLTVAGVVLFLDVVTKVLAVRLLTPGQPVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVIGIVWMGRRLVSPWWAIGLGMILGGATGNLVDRFFRSPGPLRGHVVDFFSVGWWPVFNVADPSVVGGAILLVALSLFGFDFDTVGRRRPDAPSGADAQPADPPAKPAGEVAQTDESSTVGRQAEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSY5</accession>
    <name>A0A132PSY5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysA</name>
        <name evidence="7" type="ORF">AFM11_04165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844399.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20990"/>
    <dbReference type="EnsemblBacteria" id="KWX25458">
        <property type="protein sequence ID" value="KWX25458"/>
        <property type="gene ID" value="AFM11_04165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2710"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="60"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="311"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="303"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="446" mass="47108" checksum="83AA8BC9460E1472" modified="2016-06-08" version="1">MTLLDILPSLRYAATPRLDPAIWPLTTGVDAQGRITVGRVALTDIADEFHTPAYVLDETDFRTRAQRYREALRGTEVVYAGKSLLTTAVARWVAEEGLGLDVCSAGELATALAGGVAPERIVLHGNAKACDDLRNAVDVGVGRIVLDSSMEIAYLAGLARKRQRVLIRVTPGIDVAGHRAVATGVCDQKFGFTLADRQAAQAAARVLATPQLDLVGLHCHIGSQVTDPLLYGEAIRRLITAMADIRHAHGVVLTELNIGGGHGVPYVGGDDALDLGALAGVIDETLDSACAAERFPRPRLVVEPGRAISARAGVTLYRVCAVKAQPGGRTFVAVDGGMSDNPRVGLYGAKYTVALANRHALGPTMRVTVAGRHCEAGDEIVRDVDLPADIHPGDLLAVAGTGAYHHSMASTYNMVGRPPVVAVRDGATRLLVRRETTADLLARDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT52</accession>
    <name>A0A132PT52_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844117.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21520"/>
    <dbReference type="EnsemblBacteria" id="KWX25377">
        <property type="protein sequence ID" value="KWX25377"/>
        <property type="gene ID" value="AFM11_03635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2602"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024014">
        <property type="entry name" value="DMSO2_SphG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04021">
        <property type="entry name" value="LLM_DMSO2_sfnG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="376" mass="42415" checksum="5ED8F43A2801DD80" modified="2016-06-08" version="1">MTTERIADHVKFAYWVPNVSGGLVTSDIEQRTDWNYEYNAKLAQTAENNGFEYALSQVRYEASYGAEYQHESTSFSLALLLATQKLKVIAAVHPGLWQPAVLAKLGATADHLSGGRFAVNVVSGWFKDEFTHLGEPWLEHDERYRRSAEFLQVLRKIWTEDDVDFRGDFYRIHDFTLKPKPLNTPERPNPELFQGGNSTAARRNGGYYADWYFSNGKDFDGLTEQVVDVREHARDANREVKFGLNGFIIARDSEAEAKETLREIVAKANKPAVEGFRSAVQQAGNSTADKKGMWADSSFEDLVQYNDGFRTQLIGTPEQIAERIAAYRKRGVDLILGGFLHFQEEIEYFGAKVLPLVREIEAAEQDSIDAPVLVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT80</accession>
    <name>A0A132PT80_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25515">
        <property type="protein sequence ID" value="KWX25515"/>
        <property type="gene ID" value="AFM11_04545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2788"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="93" mass="10478" checksum="F8E8BD69A991F19D" modified="2016-06-08" version="1">MSSGASATKRETREHTARASGAHVLITEQEVLFGTAAAAPLRRRRPIDIVSRALSSARARWQTSAERKPIRHDRPSRLGYLEHSLMSREMDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTA6</accession>
    <name>A0A132PTA6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF559 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844618.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20385"/>
    <dbReference type="EnsemblBacteria" id="KWX25553">
        <property type="protein sequence ID" value="KWX25553"/>
        <property type="gene ID" value="AFM11_04760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2833"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF559" evidence="1">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="32604" checksum="A58C1F493BA61808" modified="2016-06-08" version="1">MNLDWPFIGSEAVQAGVVKKHQLRSQYSAVFPNVYVPNDVRLELVDRARAAWLWSRRQGVIAGLSASGLHGAEWVDESSPIELLWSNARPPKGLRTYDVLLGDDERTLRCGLPVTSVERTAFDIGRRGRLDDAVARLDALGNATNFKPDEVIAIARRYPGARGVRQLSTALDLYDAGAQSPKETWLRLLVIRAGYPRPATQIPVRSPDRRRRYYLDLGWKAHKLAVEYDGEQHRVDPKQFAYDIIRSEDLEALGWTRVRVTKRHSTGEVLQRLARAWAASLRTDRKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTF9</accession>
    <name>A0A132PTF9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844775.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25628">
        <property type="protein sequence ID" value="KWX25628"/>
        <property type="gene ID" value="AFM11_05215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2926"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="69" mass="7508" checksum="3E2635F625D1403E" modified="2016-06-08" version="1">MGFSGDVPVVTAEAFRRYVENWMMGPGTVTEADGALIHDSYTERFVFPVVGMVGGVPVYAIEGYGNFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTM7</accession>
    <name>A0A132PTM7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844844.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25665">
        <property type="protein sequence ID" value="KWX25665"/>
        <property type="gene ID" value="AFM11_03395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2553"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="63" mass="6643" checksum="F07A2BCC281C5F5F" modified="2016-06-08" version="1">MTDPADRGPLFDGIQIGRPATGALVDAGYRTLADLPADLDELLALHGVGQKAVRVLRQARDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTN0</accession>
    <name>A0A132PTN0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_03795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13502"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844875.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21370"/>
    <dbReference type="EnsemblBacteria" id="KWX25680">
        <property type="protein sequence ID" value="KWX25680"/>
        <property type="gene ID" value="AFM11_03795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2635"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="94"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="557"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX25680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="645" mass="68150" checksum="6247D6720842E7B0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTV6</accession>
    <name>A0A132PTV6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplB</name>
        <name evidence="9" type="ORF">AFM11_00260</name>
        <name evidence="10" type="ORF">AWC31_33370</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842155.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33370"/>
    <dbReference type="EnsemblBacteria" id="KWX25769">
        <property type="protein sequence ID" value="KWX25769"/>
        <property type="gene ID" value="AFM11_00260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11580">
        <property type="protein sequence ID" value="ORX11580"/>
        <property type="gene ID" value="AWC31_33370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.53"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="8">
        <location>
            <begin position="125"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX11580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="278" mass="30427" checksum="AA62921998077699" modified="2016-06-08" version="1">MAIRKYKPTTPGRRGASVSDFAEITRSTPEKSLVRPLHGKGGRNAHGRITTRHKGGGHKRAYRVIDFRRHDKDGVNAKVAHIEYDPNRTANIALLHYLDGEKRYIIAPQGLKQGDVIEQGANADIKPGNNLPLRNIPAGTVIHAVELRPGGGAKLARSAGVSIQLLGKEGTYASLRMPSGEIRRVDVRCRATVGEVGNAEQANINWGKAGRMRWKGKRPTVRGVVMNPVDHPHGGGEGKTSGGRHPVSPWGKPEGRTRKPKKPSDKLIVRRRRTGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTW3</accession>
    <name>A0A132PTW3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_00215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842124.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33325"/>
    <dbReference type="EnsemblBacteria" id="KWX25760">
        <property type="protein sequence ID" value="KWX25760"/>
        <property type="gene ID" value="AFM11_00215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.44"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="221" mass="23339" checksum="3597CBBCE7A1229F" modified="2016-06-08" version="1">MTPGSSDPRPARSRARLLEAATALLRSGGPSAVTVDAVTRAANVARATLYRHFPSGNDLLAAAFRSLIPAAPMPPEGGTLRDRLIATVQAQAELIAEAPITITAMSWLALGGDMEQLPWRASDSQEVRTLRERVAEQYAAPFEAIFDSPDAQAELGPVDRTQAAALLLGPIVLGKLSTLPEFDYSACVRSAVDGFLATHCRAEPPRPAQVVSEANNESAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU21</accession>
    <name>A0A132PU21_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="9" type="ORF">AFM11_00510</name>
        <name evidence="10" type="ORF">AWC31_33625</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842274.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33625"/>
    <dbReference type="EnsemblBacteria" id="KWX25813">
        <property type="protein sequence ID" value="KWX25813"/>
        <property type="gene ID" value="AFM11_00510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11627">
        <property type="protein sequence ID" value="ORX11627"/>
        <property type="gene ID" value="AWC31_33625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.105"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX11627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="181" mass="19874" checksum="DD3EE48EF11C9062" modified="2016-06-08" version="1">MRVVLLGPPGAGKGTQAEKLSEKLGIPQISTGDLFRKNIGDGTPLGVEAKRYLDAGDLVPAELTNRLVEDRIDQEDAAAGFILDGYPRSVEQAGALKDMLAARNTKLDAVLEFQVSEDELLTRLKGRGRADDTDEVIRNRMKVYRDETEPLLEYYRDDLKTVDAVGGLDEVFARALRALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU32</accession>
    <name>A0A132PU32_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_00560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842305.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33675"/>
    <dbReference type="EnsemblBacteria" id="KWX25823">
        <property type="protein sequence ID" value="KWX25823"/>
        <property type="gene ID" value="AFM11_00560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.115"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="127" mass="14583" checksum="96640A84BECAA66A" modified="2016-06-08" version="1">MPAPRWVARANKIGLNRLTQFIAPWAPGWAVVIHRGRKSGRTFRTPLWAFRRPHGYVIALTYGSQADWVRNVLAAGGCELETRRHHYRLTDPRVYRDESAAGMPAFIRFMLRRVIKAPEFLSLELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU71</accession>
    <name>A0A132PU71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842509.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33985"/>
    <dbReference type="EnsemblBacteria" id="KWX25891">
        <property type="protein sequence ID" value="KWX25891"/>
        <property type="gene ID" value="AFM11_00955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.197"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="99"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="423" mass="45155" checksum="A6D06FD276BF784F" modified="2016-06-08" version="1">MTRLPPAKVRAVHSLFVEGQVDAAYLESTPLRKVVVESWRRSLATGVDPDRGGQTAAAVAALAQLRESHPLAPTLPLIRRLLVDDAVDSGVVVAVSAADGTLLWVEGDRVACRKAEAMNFVPGTDWSERTAGTNAPGTALALDRELQIRGSEHFSRVVHPWSCTAVPVHDPTTGALLGAIDLTGGSAVASTQTLALVRATAVAVENQLALLQLTRPVPAQSAEGARLTVLGADRPRWQVTDDDGHPRSSVLTGRHADILVLLIRHPEGLSADHLAMLLDDKDLDVVTIRAEMSRLRRVIGSHYIASRPYRLLAPVASDMGDVFDGLQAGDVPAALSAYTGALLPQSVSPAIGRLRTELTASLREAVLAQSARGDLALLRKWLQLPDGRDDRHAWRMLHDHAQADPVARAQARGHLAGLDSELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUK3</accession>
    <name>A0A132PUK3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_01720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842888.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26000">
        <property type="protein sequence ID" value="KWX26000"/>
        <property type="gene ID" value="AFM11_01720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.354"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX26000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="212" mass="23202" checksum="127B1E25835E518E" modified="2016-06-08" version="1">MGEPVRLDRQRIIDAAFALINEVGLDGLSTHRLAAVLDVKQPALYWHFPTKKALLEALAQEMVDRYHTRPLPKAGEGWREFLFSNARSFRRALLSVRDGARLHAGTRPTAAAVEHPERQIQFLTEAGFSAEAAAYSLIAISRYTVGAVLEQQAESEKPGDIDESAEGLPGLLARLEAAGPDVEFEFGLTALIDGIEGQLATAVSQRGRRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUR1</accession>
    <name>A0A132PUR1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_02065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34845"/>
    <dbReference type="EnsemblBacteria" id="KWX26053">
        <property type="protein sequence ID" value="KWX26053"/>
        <property type="gene ID" value="AFM11_02065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.423"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX26053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="509" mass="53931" checksum="C7A0A86C2D52A936" modified="2016-06-08" version="1">MEPQVETQTAQADREVKHLKKTLGRLDIVFLIVAAVVSIEALGQVSGFGAETFTWALVLAVFFLVPYGLIFAETGAAFTGEGGVYVWCRKAFGRPVAAIASLLTWVTQPVWVGGSMAFIASEAWSTYVMHFEHGSFADYGFKLVFIWLTVLAAIISLRHGKWIPNIGAILKILFLVVFLVTTVIYAVRNGVAGLSASDFAPTIGGLLGVTPLLLFSYLGFESGNSAAGEMKNPARDVPFAIARSAGIAAAAYLLPIFAILIVLPADQITGIGGLMEAVSTVFSVYGSAAPAMLTITGVVFAIVLMTQGSAWMIISDRMQAMAAADGAFFGGFFGRFHPQLGTPVRVNLLSGVVATVFCLVAMQVTGSSAAIFGVVLSISISTFLLSYVITIPAAVRLRTRFPDVPRPFRVPTGDAGFRALGALCFAWVALGSWVAVFPGTLDRLFGLDYDFVETWGVSQLTFEVFTLGTLAVLGILGAVGYLRARPVRAERPVGAPLDGSVAGKEAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV38</accession>
    <name>A0A132PV38_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prevent-host-death protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842979.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26027">
        <property type="protein sequence ID" value="KWX26027"/>
        <property type="gene ID" value="AFM11_01905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.391"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="84" mass="9607" checksum="46B86CCCE1CD43AA" modified="2016-06-08" version="1">MTEEISQRELRNDSGRVLRALDEGKTFVITRNREPVGELRPLRRRRLVDAHVAVETFRHAPAVDAARLRADLDSFTDQDPAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV68</accession>
    <name>A0A132PV68_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Major pilin protein fimA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843065.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34865"/>
    <dbReference type="EnsemblBacteria" id="KWX26057">
        <property type="protein sequence ID" value="KWX26057"/>
        <property type="gene ID" value="AFM11_02085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.427"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010430">
        <property type="entry name" value="DUF1028"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06267">
        <property type="entry name" value="DUF1028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="224" mass="23183" checksum="F420E833E58602D4" modified="2016-06-08" version="1">MTFSLVARDPATGAFGIVICSSSPAVASRCAHCRAGIGVVASQNVTNPALGPLVLDSLAAGSDAEAALKAALAQERYPDYRQLTVVDANGNTAVHSGSNSLGIHTHIEGEQAVAAGNLLADENVIAELLGSYANSAAAVFEEKLLDGLRAALAAGGEAGPVHSAGMLVVEDVPWPVTDLRVDYSDEPIGELAALWRLWQPQKNDYRVRGIDPTQAPSYGVPGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-12-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVM9</accession>
    <name>A0A132PVM9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_00685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family. Enoyl reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843572.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX26217">
        <property type="protein sequence ID" value="KWX26217"/>
        <property type="gene ID" value="AFM11_00685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.140"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="3">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="444" mass="47096" checksum="791A46B88317F82B" modified="2016-06-08" version="1">MSNNTQTATKRIVVIGAAGEMCRVAIDRFAKTAGGKDWKLELYDIRPEALDALAKSLPAGKATVGSFDLFDGAALRKAIEGAALVVLGAGPYIRTAEPVMEVCIEKKVPYLDLDDDEASTRAALALDAQARAAGVPILICCGASPGYTNVMTADAARDMDVVERIDICWVTGDEGPVPFGGAVLDHAIRGFAGPCWTWENGRAVQHQTFLETDVFDVGNSLGDAYRFYECAHPEAVTLPRRWPGADRIRVLGALDPPPTNGIMRGVAVAVQDGKISMDEAIDFINDLLTDKSGSLKVWRHALSGLWGTIRRGEIGVAEVAKFLALSAAKKHPPFRGTNYVRVTGKRDGEPVVSVRRAPVSGPGTPWTTMASLTGSATAAFMVLALDQHRELADLSGVLAPEDWVAPEKFYPALAATGGASLHEVVEAVVTPSTAVTSRASTSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB42</accession>
    <name>A0A132PB42_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000043">
        <property type="protein sequence ID" value="KWX19530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040745.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19530">
        <property type="protein sequence ID" value="KWX19530"/>
        <property type="gene ID" value="AFM11_35355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5802"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="321"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="410" mass="43871" checksum="3CFE00C5D91F27EE" modified="2016-06-08" version="1">MNTTTVIVGSSTGGVRAAQSLRLEGYEGDIVLVGAETELPYDKPPLSKSVLSGKAEESSIRLLTREQAEEASIRLLLGHAATGIDVAGNLLYLQDHEPLHFDNLVIATGASARPSPWGQRPGIHVLRSLDDARKLRADLLKGGELAVIGAGFIGAEAAATARTLGLEVTVIDPMPIPMSRIFNAEIAQLFGELHRNNGVTTIFGTGVEAIEGEHGSFSVRLTNGQTVQAATVLIGIGAVPNDAWLASSGLLVDNGVVLDEFCRAVDAPNVYGVGDVARWRHQKHGADIRIEHWTNAVEQASCVAHNITHPDSPREYTPVEYVWSDQHDWKIQVVGRVGGNADHVLIGDPELHGRFAALYTTDGVELYGAAIVNWPKALLACRRGMGSGIGVQELRDKLELLLEPRPTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBK7</accession>
    <name>A0A132PBK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19713">
        <property type="protein sequence ID" value="KWX19713"/>
        <property type="gene ID" value="AFM11_34280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5198"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="264" mass="29677" checksum="8C76EAAE8F238635" modified="2016-06-08" version="1">MPESCIVKRLAWLPSWALWLLIVCVSATSAYFGSRAFGWSIDWGSIADWAAAGGAFFAALVALRIANQDRELRAIEQEEGREEASKIQARLVQVEATNNSYSPTVHVKVVNFGPLPVLDVDLVAASWIEHPEARWGTNWKWSGPIDRLGPIEPLTHGTSHRILHPRSAQDDETATYWKTATFDVCFAHRDRDVPILNAAATDDRRRPTRYEQLDMDLVIITVHFTTADGLRWQVIVQGGVGDDPVRVQPRSREDRWLARIGLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBM5</accession>
    <name>A0A132PBM5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Tyrosine recombinase XerD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">xerD</name>
        <name evidence="15" type="ORF">AFM11_34420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859243.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11250"/>
    <dbReference type="EnsemblBacteria" id="KWX19735">
        <property type="protein sequence ID" value="KWX19735"/>
        <property type="gene ID" value="AFM11_34420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5228"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01807">
        <property type="entry name" value="Recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="14">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="13">
        <location>
            <begin position="123"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="11">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX19735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="318" mass="34131" checksum="A04D14A58C4943C9" modified="2016-06-08" version="1">MTTSSPLRTALDDQIQGYLDHLTIERGVAANTLSSYRRDLRRYAEHLTQRGIDDLTKVAETDVSDFLVALRRGDPEAGVVALSAVSAARAVVAVRGLHRFAAAEGLTDVDVARAVKPPTPSRRLPKSLTLDEVLALLEAAGGDSEADGPLTLRNRALLELLYSTGARISEAVGLDVDDIDTHARSVLLHGKGGKQRLVPIGRPAVSALDAYLVRGRPDLARRGRGTPAIFLNARGGRLSRQSAWQVLQDAAERAGIASAVSPHTLRHSFATHLLDGGADVRVVQELLGHASVTTTQIYTMVTVHTLREVWAGAHPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBN4</accession>
    <name>A0A132PBN4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859278.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19745">
        <property type="protein sequence ID" value="KWX19745"/>
        <property type="gene ID" value="AFM11_34260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5193"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="84"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="175" mass="19540" checksum="25546D3CEC276919" modified="2016-06-08" version="1">MSTEAIEAATFMPEHSEDLAPVVGFLANHEKRRGKAATPSYALVGVDEHDRIELPRSVHEALTKIVAALHAGKAVTVAPQTMKLTTQQAADLLGVSRPTVVRLITDNVLPAERIGNRHRLLLDDVLTYREQRRTRQYEALAATAVDIDTNDDPEQIRQDLREARRVVAEQRRAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBQ6</accession>
    <name>A0A132PBQ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859006.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02435"/>
    <dbReference type="EnsemblBacteria" id="KWX19765">
        <property type="protein sequence ID" value="KWX19765"/>
        <property type="gene ID" value="AFM11_33985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5134"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="289" mass="30187" checksum="CFCC980A6DB530D4" modified="2016-06-08" version="1">MTASSERVSDEVGRDRGLDAIEDWTTGYVRRHPIASLTTVGDQFVLGGRTLQYLFTDLFTGRFQWQEFIRQGAFMSGTAVLPTILVALPIGVTLSIQFALLAGQVGATSLAGAASGLAVIRQAASLTAAILMAAAVGSAITADLGSRTMREETDAMEVMGVSVVRRLVVPRFAAAVMVGVALTGVVCFVGFLASYLFNVYFQNGAPGSFVATFSSFATTEDMIVALIKAVIFGAIVAVVSCQKGLSTVGGPTGVANSVNAAVVESILVLMVVNVAISQLYIMLFPRVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBY0</accession>
    <name>A0A132PBY0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_33860</name>
        <name evidence="6" type="ORF">AWC31_07525</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858912.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07525"/>
    <dbReference type="EnsemblBacteria" id="KWX19841">
        <property type="protein sequence ID" value="KWX19841"/>
        <property type="gene ID" value="AFM11_33860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10029">
        <property type="protein sequence ID" value="ORX10029"/>
        <property type="gene ID" value="AWC31_07525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5110"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX10029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="98" mass="10111" checksum="61C2D3B2ED42AA36" modified="2016-06-08" version="1">MSDLGPVEQIPVGEGRTFAVDGTQIAVFRLRDGSLRAIDAVCPHKGGPLADGLADDTVVVCPLHGATFDMCSGTEAAGELAVRSYQVTAVDGAIRLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC34</accession>
    <name>A0A132PC34_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858727.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19895">
        <property type="protein sequence ID" value="KWX19895"/>
        <property type="gene ID" value="AFM11_33490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5031"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="92" mass="9857" checksum="08515940CFEDADF9" modified="2016-06-08" version="1">MDNKLTNGLILNRLLDPAQEVNREGITCYGLWTGDDGLTPSLFAESHSHYLVSGSDVIDSGDLAALAFVIAVQRLSFRSRQPGSSIAPVIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC35</accession>
    <name>A0A132PC35_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19893">
        <property type="protein sequence ID" value="KWX19893"/>
        <property type="gene ID" value="AFM11_33480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5029"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="61" mass="7099" checksum="335CF2FA9839B685" modified="2016-06-08" version="1">MQYTSYASGTPYLFMMKVAFGHNDKKIGVYELAERAIVLVDESFERLRVEESDDLTHVYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC82</accession>
    <name>A0A132PC82_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858533.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17060"/>
    <dbReference type="EnsemblBacteria" id="KWX19945">
        <property type="protein sequence ID" value="KWX19945"/>
        <property type="gene ID" value="AFM11_33165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4965"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="259" mass="26342" checksum="EFEDF5ED804250BA" modified="2016-06-08" version="1">MTDTPEPGAINLGLTGKVVLVTGGVRGVGAGISAVFAGQGATVVTCARRPVEGLPYEFHSCDVRDDFAVAALIESVVDKHGRLDVVVNNAGGSPYVPAAEASAKFSTKIIELNLLGPLSVSHHANAVMQNQDGGGTIVNISSVSGHRPTPGTAAYGAAKAGVDNLTSTLAVEWAPKVRVNSVVVGMVETEQSELFYGDAESIAAISKNVPLGRLAKPADIGWAAAFLASDAASYISGASLEVHGGGEPPHYLATTTAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCG8</accession>
    <name>A0A132PCG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_32990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858400.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32435"/>
    <dbReference type="EnsemblBacteria" id="KWX20023">
        <property type="protein sequence ID" value="KWX20023"/>
        <property type="gene ID" value="AFM11_32990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4928"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="205" mass="22383" checksum="74C8D82B8E658312" modified="2016-06-08" version="1">MTPVRPYRGIEAADRLAQRRGQLLEAGLDVLGADGAELTVRAVCQRAGLAARYFYESFNDKNDFIAAVYDWVIADIATSTQAAVAAVPVPEQTTAGMANIVRIIADDPRIGRLLFSTKLSNEVLARKRVEGIGFFAALFGQHAGDTLRVQENDQLRAMGYFAVGGVTHTISAWLSGEIAFTPEQLVDRLRSMLDALAGRPYRNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCH3</accession>
    <name>A0A132PCH3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell motility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX20028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858411.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32465"/>
    <dbReference type="EnsemblBacteria" id="KWX20028">
        <property type="protein sequence ID" value="KWX20028"/>
        <property type="gene ID" value="AFM11_33020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4935"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453169" evidence="1">
        <location>
            <begin position="46"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="103" mass="9866" checksum="10BFAAC1CA9C0B8F" modified="2016-06-08" version="1">MTLRVVPEGLTAASAAVEALTARLAAAHAAAAPVVSTVVPPAADAVSLQTATGFSAHGAQHSALAAHGVEELGRSGVGVAESGASYATGDAMAASSYLIARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCX0</accession>
    <name>A0A132PCX0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857915.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31705"/>
    <dbReference type="EnsemblBacteria" id="KWX20191">
        <property type="protein sequence ID" value="KWX20191"/>
        <property type="gene ID" value="AFM11_32145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4756"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="282" mass="30166" checksum="612860C4CBC62DEF" modified="2016-06-08" version="1">MPAITEWPLQQIETNGIVANTAIVGEGPAILLLHGFPHTWRLWTDVIPALARHHRVIAPDLRGLGASTRPVDGYDAASLATDAEGLLDVLGEPQADVVGIDLGTSPAFLLAMRRPSRVTRLVVMESVLGTLPGAEDFLAGGPPWWFGFHQAPDLAEAVLTGNEASYIGWFLSAGTLGRGVPPDIHRYFVNAYTGRGALRSAFAHYRAMPTTARQIAAATAKSRLTVPTLAIGSHPVGDALARQLRPLADDLTEHVIADCGHIIPLDRPDLLIPLLLRFLSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCZ8</accession>
    <name>A0A132PCZ8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F420_oxidored domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_33865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858915.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19842">
        <property type="protein sequence ID" value="KWX19842"/>
        <property type="gene ID" value="AFM11_33865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5111"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="2">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="213" mass="22051" checksum="0F004F02FE7B5EE6" modified="2016-06-08" version="1">MRYAIIGAGNIGSAVAGHFNRTGTDVALAASRGIDAVRGTAEAIGPHVIPSDVTDALRADIVILAVPFEAVQDLVGSVPDWQGRIIVDATNAIDYRDFSPADLGGRASSDLVAEWAQGGRVVKAFGHTWARVLARDPGDGHGGQRVLFVSGNHPEANSEVAQLISALGFEAVDLGRNDGGGLLQQFGGPLTTKSFISQPISGSSPAEMDLTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD14</accession>
    <name>A0A132PD14_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldedh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_31885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20206">
        <property type="protein sequence ID" value="KWX20206"/>
        <property type="gene ID" value="AFM11_31885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4703"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="8"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="456" mass="48002" checksum="C5A5BE12DDB0ECE4" modified="2016-06-08" version="1">MTARAAGDGRVIGHTFEATPDQLDRATDAAVQAFSQTRRLASFERGEMLRDIADRILADAEGLAATLAAEIGKPIGDARLEVRRTAGAFRMAGEEAERIGGEVMPLDLLPTSRGRWGITRQMPLGPIAAISPFNVPLSLSAHKVAPALAAGCTVVLKPDSRAALTLLRLAGLIVEAGVPAGAVSVLPMSTEVGDRMVTDDRFRMVSFTGSVQAGWDIRSRAGTKKVALELGGNAPVIVDETADVAHAAARTVAAGFKYAGQLCISAQRVFVHRAVATEFVDALTKGAAALKVGDPLDETTQVGPMISVDAADRIRSWIDEAVQGGARLLTGGEGSGAFVTPAVLDQVPDTAQLSCQEAFGPVVVVNTFDDLDAAFAAADGTPYGLQAGYFTRDLHRAWRAYEQLEFGTVVINDAPAFRVDSMPFGGVKKSGLGREGIRWAIADMTEPRLLVLTPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD42</accession>
    <name>A0A132PD42_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857746.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20137">
        <property type="protein sequence ID" value="KWX20137"/>
        <property type="gene ID" value="AFM11_31820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4690"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="249" mass="25920" checksum="F3E9C9BB37E9C20C" modified="2016-06-08" version="1">MSPRPIALITGSSRGIGFGIARGLIAAGYDVVLNGRTENQLRSGKQQLEEIGGTAHVATFDVADADAVQAAVENIESGVGPIEALVNSAGVVTRTPLIDLSLEQWNRTLEVNLSGCFVVSTCVARGMIVRGRGKIVNIGSVQSALSRGGLGAYAASKGALASLTRTMCVEWAGHNIQVNALSPGYVLTDMNAEIRRDETLDAWVVGRTPAARWGTVADVVGPAVWLCSEQAAFVNGQTIYVDGGITAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDB1</accession>
    <name>A0A132PDB1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_30695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857089.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26415"/>
    <dbReference type="EnsemblBacteria" id="KWX20325">
        <property type="protein sequence ID" value="KWX20325"/>
        <property type="gene ID" value="AFM11_30695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4041"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="36"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="512" mass="53764" checksum="E9B3FC2E48A447CE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDC9</accession>
    <name>A0A132PDC9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_31300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857670.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25455"/>
    <dbReference type="EnsemblBacteria" id="KWX20304">
        <property type="protein sequence ID" value="KWX20304"/>
        <property type="gene ID" value="AFM11_31300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4165"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="324" mass="34599" checksum="996340C318487ABF" modified="2016-06-08" version="1">MVGWLDRLQRRSRVAGFLIAVVYKYVDDQGGYLAALITYYAFVSLFPALLLLTTVLGVVLVGRPDLQEQILQSAVAQFPVIGDQLGQPQGLSGGTIGVVIGIAGALYGGLGVGQAVQNAMDTLWAVPRNNRRDPIRARLLSFLLLLVLGTALIATTILAAVGRASASFGIAGRVGIVVVSVLINAGVCLIVFRFATARTVTFRQAAPGAFLAAVIWQLLQWFGAVYVAQIIKTSSATNSVFALVLGMLAFLYLVATTLLLCAEANVVAADHLYPRALLTPFTDNVKLTRGDRKTYTGQAKAQRAKGFQRIDVSFDDRRPKDGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDD0</accession>
    <name>A0A132PDD0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857103.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26440"/>
    <dbReference type="EnsemblBacteria" id="KWX20330">
        <property type="protein sequence ID" value="KWX20330"/>
        <property type="gene ID" value="AFM11_30720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4046"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="456"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="547" mass="58497" checksum="5C2631985EA60AB6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDK9</accession>
    <name>A0A132PDK9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857340.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26895"/>
    <dbReference type="EnsemblBacteria" id="KWX20410">
        <property type="protein sequence ID" value="KWX20410"/>
        <property type="gene ID" value="AFM11_31185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4142"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="247" mass="25701" checksum="6FAAAAD92416A14F" modified="2016-06-08" version="1">MKITVFGATGQIGSKVVELLTESGYDVVAASRQSGADVLTGDGLKEALDGAEVLVDVVNSPSFADDPVMDFFTTSTRNLVEAAKATGVGHYVALSIVNADELPASGYMRAKVAQEKAIVASGLPYTIVRATQFHEFAEAITGSLVVGDEVRVPDARIQLIAAPEVAAEVARAAQTAAINGVVNIGGPEKLSFAEMAQTVLDKQGDDKPVVVDPNATYFGTSVDDNSLVTGDDGKLAGIRFADWIAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDL9</accession>
    <name>A0A132PDL9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyrrolo-quinoline quinone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857299.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26840"/>
    <dbReference type="EnsemblBacteria" id="KWX20431">
        <property type="protein sequence ID" value="KWX20431"/>
        <property type="gene ID" value="AFM11_31130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4130"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453166" evidence="1">
        <location>
            <begin position="33"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="427" mass="44901" checksum="8283F1733D4C9587" modified="2016-06-08" version="1">MIRRYLALAVAALLTGLLAGCENTDSWVEAHAASGWAAQYGDAANSSFTTTPGADNLRLEWSRSAKGDMAAQVALGSGQYLAVNAQSAGGCSLMVWEADNNARQRWCTRLVQGGGWSSPLFDGFDNVYVGQPGAMLSFPPTQWIRWRQPVIGMPTTPRILTDGQLLVITHLGQVLVFDAHRGTVEGTPLDLVSGVDPTDPQRGLGDCQLARSRCPVAAAPAFSAASSTIVLTLWEPGAEAPVLIGLKYRPGQTPLLAREWTSDAVGRGPFASPVLSADGATAYVNGRDEQLWAINTADGSAKWSVPLDYLAQTPPSVSPDGLIVAGGGPDAKLMAVRDEGDRGEVVWTRDDVTPLSTSSRSGGVGYTVAREGGHGQALLVFDSADGRTINTYPLPEATGWPVGVSIAHDRRVVTATSDGQVYGFAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDT4</accession>
    <name>A0A132PDT4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856792.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20454">
        <property type="protein sequence ID" value="KWX20454"/>
        <property type="gene ID" value="AFM11_30205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3937"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024426">
        <property type="entry name" value="DUF2694"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10904">
        <property type="entry name" value="DUF2694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="97" mass="10980" checksum="612FBE053867E3EA" modified="2016-06-08" version="1">MLEATTRVESFEAASRDESVIVRVGRCGQTLAVQLEAPAMELSDDELANRIVRLNTLAYLRSQCALRQEMVANRVEGILPQLPTEQQVRQYQQTIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDU8</accession>
    <name>A0A132PDU8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856972.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00530"/>
    <dbReference type="EnsemblBacteria" id="KWX20505">
        <property type="protein sequence ID" value="KWX20505"/>
        <property type="gene ID" value="AFM11_30525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4005"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="129" mass="15223" checksum="8F15441BD4C4F502" modified="2016-06-08" version="1">MRVRGFGELEAKIMDRIWNHDPESVTVRDVFDELAEERQIAYTTVMSTMDNLYTKGWLERERDGRAYRYWPTLTREQHSAQLMREALDGGGRSELVLSYFIEQIDPQDSDRLRAALRALARRSTRAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE11</accession>
    <name>A0A132PE11_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856475.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24970"/>
    <dbReference type="EnsemblBacteria" id="KWX20565">
        <property type="protein sequence ID" value="KWX20565"/>
        <property type="gene ID" value="AFM11_29630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3818"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="30415" checksum="629666F9251FB201" modified="2016-06-08" version="1">MPTVDLPAGPVAYEDTGGDGPVLVFGHGLLMDGRQWRKVLPLLPGYRCITPTLPMGAHTTPMNDDAVLSEVGMAHILADFLDALGLDDVTLVLNDWGGGQFVISEGRDKRVGKLVLASCTAFDNYPPKPARPAALLCHMPGGGWLLSRMFGTKFFRRSRRAYGAMSKKGLPDSLYDDWFRPAVENSAIRRDLVKFATGAPSRRRLLEMSEQMRTFTRPVLVVWAREDLMMPLEHADRLMALYPDATKIVIDDSWTLIPEDQPEAMAKALRDFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE31</accession>
    <name>A0A132PE31_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856535.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25090"/>
    <dbReference type="EnsemblBacteria" id="KWX20585">
        <property type="protein sequence ID" value="KWX20585"/>
        <property type="gene ID" value="AFM11_29750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3842"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="405" mass="43816" checksum="5D199A986C60CAAA" modified="2016-06-08" version="1">MTDNDIRVIRPLAGVRVLELGNYIAAPTAGRMLADFGAEVIKVERPVTGDELRNWRLYAGTTSMLYRTINRNKKSIVLDLKTEQGRGVVLDLLKHCDVLLENFRPGTLEKWGLGPEQLDEANPNLVITRISAFGQTGPLAQRPGFAAVAEAYGGLRELVGDPDRPPVRTGVSIGDSIAGIYAAFGTVMALFQREHTTVPLEQRIVDVALNEAILSVMESLVPDYLAYGVKRQRVGGRMEGIAPSNAYPCADGTSIIVAGNGDAIYQRYMTTIGRPDLAADPDLQTNAGRWQRRDELDAAIAEWSSRLTRDEALKLLDEAGVPSGPIYTAADICDDEQYESRNMIQHFEVDTGGAEPQSVGFPGIVPVIGGASLPIRSVGPDLGEHTHEVLSNLLGLDDDEIGALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEG1</accession>
    <name>A0A132PEG1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20728">
        <property type="protein sequence ID" value="KWX20728"/>
        <property type="gene ID" value="AFM11_29420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3775"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="68" mass="7396" checksum="E411133978008D55" modified="2016-06-08" version="1">MPAMSDADIAAGRHRDRRAKTARDELFDAPTPPRVTPENDTTPVGGHGHIRQRVTVAIKGLIATIRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEI2</accession>
    <name>A0A132PEI2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040178.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20746">
        <property type="protein sequence ID" value="KWX20746"/>
        <property type="gene ID" value="AFM11_29205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3726"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453029" evidence="1">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="2">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="114" mass="12123" checksum="D4BEC7EBAC6C2442" modified="2016-06-08" version="1">MAMCWAAGLGVATAQAPHAHADPVAYLVNVTVRPGYGFPNADAALGYGYGICDKLSGGEGYGQLIGDLQADFHTADDYQASYLITQSVNELCPALIWRLRNSAAHDWPPPRDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEL2</accession>
    <name>A0A132PEL2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856121.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20776">
        <property type="protein sequence ID" value="KWX20776"/>
        <property type="gene ID" value="AFM11_28445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3567"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045676">
        <property type="entry name" value="DUF6194"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19694">
        <property type="entry name" value="DUF6194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="142" mass="15482" checksum="62B791412CB91667" modified="2016-06-08" version="1">MTIRELIDLISAMDGVLVLQPRAGDGSPEIAWGDVFFYYAPDGVVPRTQPFATIITKDYPDDDSCHLNRPGAFRLNIAAGAGHTTQSEALDDTVLVHPVYGRQGWVAIVNPGPNTSVTAAELLALARRRAEARYRTTGFVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEV7</accession>
    <name>A0A132PEV7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ClpX-type ZB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_27575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855608.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10105"/>
    <dbReference type="EnsemblBacteria" id="KWX20865">
        <property type="protein sequence ID" value="KWX20865"/>
        <property type="gene ID" value="AFM11_27575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3389"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="123" mass="13816" checksum="8EF60A28078C50C8" modified="2016-06-08" version="1">MGKAVSAVMYCSFCGRESRQVDKLISGLGVYICGDCVFKCVAILEDRRDQDMPPLKDREEYSDDELLDEIPRVAATTANVEADLRARVSELRQRGVAWSRIAAALGVTRQSAWERFTHDDKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF29</accession>
    <name>A0A132PF29_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF732 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_28030</name>
        <name evidence="4" type="ORF">AWC31_10550</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855814.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10550"/>
    <dbReference type="EnsemblBacteria" id="KWX20931">
        <property type="protein sequence ID" value="KWX20931"/>
        <property type="gene ID" value="AFM11_28030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08930">
        <property type="protein sequence ID" value="ORX08930"/>
        <property type="gene ID" value="AWC31_10550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3480"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453040" description="DUF732 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="2">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX08930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="112" mass="12205" checksum="1F05A22DE75DE27F" modified="2016-06-08" version="1">MKLAGLAVLGAAAAIAFAAPAHAEIDTDFANELHTYGIYGPRDYNAWIGKLTCKRLHNAVDHNANDSVAFLSKNLDKDSTTAQHWQFLGTAINYYCPDLRHVMEQAAADSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF78</accession>
    <name>A0A132PF78_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855971.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10305"/>
    <dbReference type="EnsemblBacteria" id="KWX20981">
        <property type="protein sequence ID" value="KWX20981"/>
        <property type="gene ID" value="AFM11_27775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3428"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="43"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="213" mass="23931" checksum="6BD58C8A2BFF7FBB" modified="2016-06-08" version="1">MPQLLRVQNFNVSRDGFGAGLNQSFERPFGDADPGDMFAWAGATASWPNRTDPGGSRGLDDYFTRDFAHNIGAEIMGRNKFSPHRGPWRDHEWQGWWGDEPPFHTPVFVMTHHERPSFTLSDTTFHFVNGDPDTVLEQARQAAQGKDVRLGGGATTIRQFLDADLVDSLHVAVSQIEIGAGSRLWESPDELDDRFHHDVVPSPSGVTHHLFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFK8</accession>
    <name>A0A132PFK8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20762">
        <property type="protein sequence ID" value="KWX20762"/>
        <property type="gene ID" value="AFM11_28355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3545"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="29460" checksum="B1A9C685E1437CC8" modified="2016-06-08" version="1">MALVSGLVQPAPARADGQGCPAQVAALDDNQARIAEHNARGGGPGPPEIVIPYNREADQLNAEKDALVASLQACQLAIGKLRDNGPAPKALKPTVLSDLGKAAAAARPQWTSPTPPVKLGDGRVTVPKDHALRPVWDVVKNQVTPLKPYPNVPLQGERRPSVGDSHPSGYTVGSKPNGAPAVSADHIVPKVEILYLPRFLELTPENMWEVLNAASNLQWLPSEVNTRNKNSKSAADMQDVDPDWQKEQVALQDRKRRELTDMIAQLADSQLPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG11</accession>
    <name>A0A132PG11_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854418.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21299">
        <property type="protein sequence ID" value="KWX21299"/>
        <property type="gene ID" value="AFM11_25570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2977"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="88" mass="10024" checksum="35E07AC7B23DF9E5" modified="2016-06-08" version="1">MMDFQWRDYDSASLPSLSDEQLREGIAYYDRRVKEAHAAKVQAIARLKALTTPTALGARSWVEVVSSRLNINHDQARRLLREVALAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG26</accession>
    <name>A0A132PG26_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_28120</name>
        <name evidence="3" type="ORF">AWC31_10665</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855853.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10665"/>
    <dbReference type="EnsemblBacteria" id="KWX20942">
        <property type="protein sequence ID" value="KWX20942"/>
        <property type="gene ID" value="AFM11_28120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08947">
        <property type="protein sequence ID" value="ORX08947"/>
        <property type="gene ID" value="AWC31_10665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3499"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAP_DH_C" evidence="1">
        <location>
            <begin position="146"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX08947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="358" mass="37237" checksum="7C7A8216AFC2484F" modified="2016-06-08" version="1">MVFRVAHIGTGNVGRLALTGLLTNPAYELTTLCVSTESKVGKDAGELAGLDLSTGVTAVADLDAVIAAKPDCAVYCAMGDTRGPEAIADVVRLLAAGINVVGSAPVSLQFPWKLMPGKYIAGIEEAAQAGNASLFITGVDPGFANDLIPFALAGTCQSIEQVRCMEIADYATYDGVTVMFDVMGFGKPLDETPILFQPGVLSIAWGTSIRQLAAGLGIEIDDITEVCEKEPAPEAFDIAAGHVAKGTVAALRFEIRGMVKGEPVIVIEHVTRLRGDLRPDWAQPAQPGGSYRVEIVGEPSYAVDICPTSRKGDHNHAAIVAAAGRIVNAIPDVVAAAPGIRTTLDMPLVTGKGLYGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG66</accession>
    <name>A0A132PG66_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="11" type="ORF">AFM11_25695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854481.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36200"/>
    <dbReference type="EnsemblBacteria" id="KWX21321">
        <property type="protein sequence ID" value="KWX21321"/>
        <property type="gene ID" value="AFM11_25695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3003"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX21321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="146" mass="15737" checksum="6636EC11E5CA1D69" modified="2016-06-08" version="1">MTDRRLLLVNGPNLNLLGTRQPEIYGSTTLADIEHSVTELAAELGFDVRTVQSNHEGELIDAIHAARTDCAGIIINPGAYSHTSVAIPDALTAVERPVVEVHLSNIHRREAFRHHSYVSAVAEVVIAGAGPAGYEYAVRYLAGRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGQ9</accession>
    <name>A0A132PGQ9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="5" type="ORF">AFM11_25210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854210.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27530"/>
    <dbReference type="EnsemblBacteria" id="KWX21511">
        <property type="protein sequence ID" value="KWX21511"/>
        <property type="gene ID" value="AFM11_25210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2403"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="156" mass="16975" checksum="431B7E352B3B3B1C" modified="2016-06-08" version="1">MAVKIKLTRLGKIRNPQYRIAVADSRTRRDGRAIEVIGRYHPKEEPSLIEIDSERAQYWLGVGAQPTEPVLALLKITGDWQKFKGLPGAEGTLKVKEPKPSKLDLFNAALAEAESGGTTEATTPKKKKAPKKDEAKDETAPEAKADEPAAEAASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH22</accession>
    <name>A0A132PH22_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_25190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854198.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27510"/>
    <dbReference type="EnsemblBacteria" id="KWX21507">
        <property type="protein sequence ID" value="KWX21507"/>
        <property type="gene ID" value="AFM11_25190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2399"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="179"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX21507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="537" mass="59072" checksum="6408211BC9399AFE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHF0</accession>
    <name>A0A132PHF0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_23165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853041.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27930"/>
    <dbReference type="EnsemblBacteria" id="KWX21760">
        <property type="protein sequence ID" value="KWX21760"/>
        <property type="gene ID" value="AFM11_23165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1985"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="327" mass="36021" checksum="AE91620738F9E35A" modified="2016-06-08" version="1">MTALLEVTDLVKHFPIKSGVVIDREVARVRAVDGVSLSLNEGETLGLVGESGCGKSTLCRLILQLTQPTSGSVRFDGHELVGRSQRDLRPMRRQMQMIFQDPFASLNPRKRVGQIIGDPIELHGLASGSEARRRVHELLDRVGLQAEHYNRYPHEFSGGQRQRIGIARALALQPKLIIADEPVSALDVSVQAQIINLLKDLQQEFGLSYLFVAHDLGVVRHVSDRVAVMYLGKIVETADADSLYRRPFHPYSGALLSAVPIPDPRRNAARERLVLEGDVPSPIDPPAGCSFHTRCPWCTEVCNVETPALLDLTPGHSAACHHPRNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHH4</accession>
    <name>A0A132PHH4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_23445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853196.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21808">
        <property type="protein sequence ID" value="KWX21808"/>
        <property type="gene ID" value="AFM11_23445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2044"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="131" mass="12735" checksum="3D0AA82CCF927A49" modified="2016-06-08" version="1">MRVTLVRGRLRLVGDSSSSSSVSDRVRGSSVGPDGSGVEDPDVSDGDVPVVPDTSVGNPNSVVTGGLVRVMVGVVVAVEVPDEAGANVGSTNSIGASCGLSALLVSATTPQTTSAITVSAATLAPSTAGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHT0</accession>
    <name>A0A132PHT0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853033.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27910"/>
    <dbReference type="EnsemblBacteria" id="KWX21757">
        <property type="protein sequence ID" value="KWX21757"/>
        <property type="gene ID" value="AFM11_23145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1981"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453364" description="YkuD domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="2">
        <location>
            <begin position="54"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="217" mass="22618" checksum="A36CF548A73E1C24" modified="2016-06-08" version="1">MRRLLVLLCAAVLALMCAPAAVAVNAPWFARAVGSATQVISVVGVGGSKAKMDVWQRGSAGWQPIGIGIPANIGANGMAAKTHDGNMATPMGIFTLDFAFGTAPNPGGGLQYIQVGPDHWWDGDMKSPTYNTMQVCKKAQCPFDTDPASGTENLQIPQYKHAVVMGVNKARVPGNGGAFFVHTTDGGPTAGCVAIEDATLVQIMRWLRPGALIAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHU8</accession>
    <name>A0A132PHU8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_23200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853070.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27965"/>
    <dbReference type="EnsemblBacteria" id="KWX21767">
        <property type="protein sequence ID" value="KWX21767"/>
        <property type="gene ID" value="AFM11_23200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1993"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017743">
        <property type="entry name" value="ADH_phosphonate_catab-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03366">
        <property type="entry name" value="HpnZ_proposed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="340" mass="35065" checksum="B5C43B0501256433" modified="2016-06-08" version="1">MDTLTPRVTLAAVWTGGSEVELQKVEIPELGDGDVLVQVRLATVCGSDLHTVTGRRSAACPSILGHEAVGDVVAAGPRAPVQVGQRVVWSVTVTCGECTRCRSGLTAKCTSVRKVGHEPFDGDWPLSGSYAEQVVLPKGTTIAVVPSTLPDTVAAPAACATATVMATLEAAGEVAGRRVLIGGAGMLGLTAVAACAEAGADVQVVDIDPGRLELATEFGGRAADGGPVDVAIDYTGSTDAVAQALGRLDIGGVLVLAGSVMPGAPLAVDPEAVVRQWLTITGVHNYEPRHLHRAVEFLDRTRDRYPWHSLVEAPVPLDDIASAFCAPPVGKLRTAVAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHX1</accession>
    <name>A0A132PHX1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852738.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08725"/>
    <dbReference type="EnsemblBacteria" id="KWX21935">
        <property type="protein sequence ID" value="KWX21935"/>
        <property type="gene ID" value="AFM11_22485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1847"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="102"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="405" mass="42875" checksum="F3F77B9C56CEEBB4" modified="2016-06-08" version="1">MDDVAVTQTLVLRFADVGIATYATLRVVGDPQRSVTWVIEEPYLTAACDALDNALPDPCGSETPAQAIQRAVASGAFADPGAELDLARTLGAQLIGVAGWQLLADCAASPRAVLFVTPSPRLGRVPWGQLAVPGPDGFRLMELVDVLMAVPPNIVHGPRRPARWAERRDGPAVLVLDPRIPGQRPDSALGSVLGRPSPQTPLARHFSGFTGEQALPAVADAVELFRRTDTDRRWLAEACARAPARLLYVGHASAAEHDAGHADRAALHLAEERPLTAGDVMSVQLSVPPRVGLLACASGGDYRFDEATGLVAAMILGGAQLVTATLWSLPTTAGYRQFAPGPTDSAVDPMADIVVGVDLAHREDDAGVAVNRWQRAQLRRWRAGDVTASPLYWAALATFAVDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHY6</accession>
    <name>A0A132PHY6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853191.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21807">
        <property type="protein sequence ID" value="KWX21807"/>
        <property type="gene ID" value="AFM11_23440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2043"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="143" mass="14981" checksum="50EFCCD5E839FCF6" modified="2016-06-08" version="1">MSNYYSDDEPTQYSQSYGDYEAYPPPTEPLEPEPVPWYHKPAALIGFGALGAVIAALVIYALVQLFSSDTPSTTTTTTTTPTTTSAVAPVAPPPTQTVTETVPQTTTTAVPTTTTTTTTTTTTTTTTTTTTTTTDTTTPEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIA9</accession>
    <name>A0A132PIA9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852955.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08720"/>
    <dbReference type="EnsemblBacteria" id="KWX22043">
        <property type="protein sequence ID" value="KWX22043"/>
        <property type="gene ID" value="AFM11_22490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1848"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="576" mass="63454" checksum="0B001AE256691B11" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIC5</accession>
    <name>A0A132PIC5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor SigI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_21595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852375.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04400"/>
    <dbReference type="EnsemblBacteria" id="KWX22100">
        <property type="protein sequence ID" value="KWX22100"/>
        <property type="gene ID" value="AFM11_21595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1667"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="283" mass="30802" checksum="72DA55632E46BD4D" modified="2016-06-08" version="1">MTDSALVEQAWRDHRPYLVNLAYQMLGDIGEAEDAAQEAFLRLSRAEEQHIDDVRAWLTVVTGRLCLDQVRSARARLERPDAGEAVQTTPAADPDPADRVTLDDQVRAALLTVLDRLSPAERVAFVLHDVFGVPFDEIAESVGRPVGTCRQLARRARLKFAETTPRPAQIEATEHQLVVEKFITACANGDLQALTEVLDPTVWGVATFVGDPAPPPQINHGRERVAPNLLHHLAGGTLVGGAVGEPGVLAFLDRRLVAVLVFTVRGGRIAKIEATVDPSARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PID3</accession>
    <name>A0A132PID3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21675</name>
        <name evidence="2" type="ORF">AWC31_04480</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852395.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04480"/>
    <dbReference type="EnsemblBacteria" id="KWX22110">
        <property type="protein sequence ID" value="KWX22110"/>
        <property type="gene ID" value="AFM11_21675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10552">
        <property type="protein sequence ID" value="ORX10552"/>
        <property type="gene ID" value="AWC31_04480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1683"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="187" mass="19808" checksum="969557DF76872900" modified="2016-06-08" version="1">MLTSVTTIDGFSIAVDVAGPEKGATVVLLSAGHHGPAAYEAVCQRLHTASLRTIVIGPDPRLTAKSVVGILDSLNIKWALLVGDRLGGELAWELAATRLDKFIGLVVVDRGHPRVADPTGVIRDGGCPPVEMNTTALVSNPAARAVAKASQRYVYGDFRLVEMLGRRNAQDSTAQLAAEIVLRTSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIK8</accession>
    <name>A0A132PIK8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-lactamase</fullName>
            <ecNumber evidence="2 5">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_22160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2 5"/>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852564.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04920"/>
    <dbReference type="EnsemblBacteria" id="KWX22198">
        <property type="protein sequence ID" value="KWX22198"/>
        <property type="gene ID" value="AFM11_22160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1781"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023650">
        <property type="entry name" value="Beta-lactam_class-A_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00118">
        <property type="entry name" value="BLACTAMASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00146">
        <property type="entry name" value="BETA_LACTAMASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453289" description="Beta-lactamase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="7">
        <location>
            <begin position="54"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="30969" checksum="33C9BFADBC9A2BA8" modified="2016-06-08" version="1">MTGLSRRNVLIGSLAAVAAVGVSSRTAYAVPVDDQIGELERRHNAVIGIYAVNLDSNRIVSHRADDMFAMCSTFKAYAAGRVLQMVGRDQLSLDNRVFVDPDAIVMNSPVTEPRAGSEMTLGELCAAALQRSDNTAGNLLLKTIDGPAGITAFARSIGDERTRLDRWEVELNSAIPGDPRDTSTPAALAIGYRALLVGDALSPPQRRQLEDWMRANQTSSMRAGLPAGWTTADKTGSGDYGSTNDVGVAYGPAGQRLLLAMMTRSQTDDPKAANLRPLIGELTASVLPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIQ3</accession>
    <name>A0A132PIQ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852604.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04390"/>
    <dbReference type="EnsemblBacteria" id="KWX22216">
        <property type="protein sequence ID" value="KWX22216"/>
        <property type="gene ID" value="AFM11_21585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1665"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="146" mass="15648" checksum="14C5625B9F3319CF" modified="2016-06-08" version="1">MADPRPPRWLKPMNKVMMAVQRLGIRTGPAMVLTVPGRKTGVPRSTPMTPFVHDGGLYTVAGYPGADWAANARAAGAGTLSQGRRSRRVTIVELTPEQSRPVLRSFAVKVPVGVGFAKRSGLVIDGTPDEFEALAGRLTVFRLDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIV0</accession>
    <name>A0A132PIV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_20865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852105.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06280"/>
    <dbReference type="EnsemblBacteria" id="KWX22288">
        <property type="protein sequence ID" value="KWX22288"/>
        <property type="gene ID" value="AFM11_20865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1512"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="282" mass="29901" checksum="2C6B1F6FF2103108" modified="2016-06-08" version="1">MTAPTRGQRKPVVLLRPVPGNSVVHQLWAGTKLLGVAIIGVLLTFYPGWVPIGFVALLALVIARLAHIPRGAVPTIPVWLWIVIALGALTATFAGGAPVIDVGSIEIGLGGLVNFLRLTALAFVLIGLGALVSWTTNVADIAPAVATLGRPLRVFRIPVDDWAVTIALALRAFPMLIDEFRTLYAARRLRPKERAETFRGRIRRLVSDLVDLLAAAVTVALRRADEMGDAITTRGGAGQISAAPSRPKSRDWVAFAILAVVCGTALALELTVLGTSLPRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ01</accession>
    <name>A0A132PJ01_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21125</name>
        <name evidence="3" type="ORF">AWC31_06490</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852198.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22330">
        <property type="protein sequence ID" value="KWX22330"/>
        <property type="gene ID" value="AFM11_21125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09855">
        <property type="protein sequence ID" value="ORX09855"/>
        <property type="gene ID" value="AWC31_06490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1572"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="106" mass="11609" checksum="3037DA9FC41E4006" modified="2016-06-08" version="1">MSYRHQILRNLKFGTLADFVGAEKEKNALRIQAGLTPYAIWSPAFGGLHHLVLEAEFESMAAFEAEHLAAKAIDGIAALNARQLECVIEGTAQDRMQRLSLEAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJC2</accession>
    <name>A0A132PJC2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_20050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851891.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28465"/>
    <dbReference type="EnsemblBacteria" id="KWX22449">
        <property type="protein sequence ID" value="KWX22449"/>
        <property type="gene ID" value="AFM11_20050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1346"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="175"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="429"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="462"/>
            <end position="469"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="637" mass="70449" checksum="FD41A8A8133E19BC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJI0</accession>
    <name>A0A132PJI0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851866.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28595"/>
    <dbReference type="EnsemblBacteria" id="KWX22424">
        <property type="protein sequence ID" value="KWX22424"/>
        <property type="gene ID" value="AFM11_19920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1318"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="134" mass="14407" checksum="F8BCEA8F4A5AE50F" modified="2016-06-08" version="1">MTTEAPEGLGKGFDTELGLTYLELTPDGGRAELKIHDKLLQPWGIVHGGVYCSIVESLASVCGHIWLSENGGGTVVGVNNNTDFLRAIGSGTVTAVSTPIHRGRRQQLWLITITDENDRLVARGQVRLQNMPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK08</accession>
    <name>A0A132PK08_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19495</name>
        <name evidence="6" type="ORF">AWC31_15580</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851756.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15580"/>
    <dbReference type="EnsemblBacteria" id="KWX22678">
        <property type="protein sequence ID" value="KWX22678"/>
        <property type="gene ID" value="AFM11_19495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17843">
        <property type="protein sequence ID" value="ORX17843"/>
        <property type="gene ID" value="AWC31_15580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1232"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024188">
        <property type="entry name" value="GltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043578">
        <property type="entry name" value="GltB_archl_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500061">
        <property type="entry name" value="GOGAT_lg2_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_synthase" evidence="4">
        <location>
            <begin position="82"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX17843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="455" mass="48081" checksum="D6E100C6AF287280" modified="2016-06-08" version="1">MTFTTDDRARLGLRESATFDRPTIAAIQRAAETGIYDIRGWGAKRPLPHFDDLLFLGASMSRYPLEGYRERCGTDVVLGDRNAKHPLHLDIPVTIAGMSFGALSGPAKEALGRGASEAGTSTTTGDGGMTPEERGQSKHLVYQYLPSRYGMNPDDLRKADAIEVVLGQGAKPGGGGMLLGQKISPRVAGMRTLPEGIDQRSACRHPDWTGPDDLTIKINELREITDWEKPIYVKVGATRTYYDVKLAVHAGADVVVVDGMQGGTAATQDVFIEHVGIPTLAAVPQAVQALQELGVHRAGASGACGATGNKGVQLIVSGGIRSGADVAKALALGADAVAIGTAALIALGDNHPRYAHEYEKLGSAAGFYDDFQDGRDPAGISTQDPELAARFDPIEGGRRLANYLRVLTMEAQTIARACGKAHVCHLEPEDLVAVTIEAAAMARVPLAGTNWIPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK13</accession>
    <name>A0A132PK13_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_19295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851681.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15380"/>
    <dbReference type="EnsemblBacteria" id="KWX22643">
        <property type="protein sequence ID" value="KWX22643"/>
        <property type="gene ID" value="AFM11_19295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1192"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020803">
        <property type="entry name" value="PKS_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00828">
        <property type="entry name" value="PKS_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_MT" evidence="3">
        <location>
            <begin position="165"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="437" mass="48340" checksum="DF281A2B131F89B2" modified="2016-06-08" version="1">MTTFRENAAHASDRKLSLAEILEIFAAGQLPLKFTAYDGSSAGPDDATLGLDLKNPRGTTYLATAPGDLGLARAYISGDLDTHGVHPGDPYPLLCALADKMNFKRPPARVLANIVRSIGFEHLVPIAPPPQEALPRWRRVVEGFRHSKTRDAEAIHHHYDVSNTFYEWVLGPSMTYTCACYPTADATLEEAQDNKYRLVFDKLRLQPGDRLLDVGCGWGGMVRYAARHGVKALGVTLSREQATWAQKAIAEEGLGELAEVRHGDYRDIVETGFDAVSSIGLTEHIGVHNYPSYFGFLKSKMRTGALLLNHCITRHDNRTGAAAGGFIDRYVFPDGELTGSGRIITEVQDVGLEVLHEENLRHHYAMTLRDWCANLVEHWDEAVAEVGLPTAKVWGLYMAGSRLGFETNVVQLHQVLAVKLDERGHDGGLPLRPWWEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK43</accession>
    <name>A0A132PK43_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiocyanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_19470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851746.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15555"/>
    <dbReference type="EnsemblBacteria" id="KWX22673">
        <property type="protein sequence ID" value="KWX22673"/>
        <property type="gene ID" value="AFM11_19470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1227"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042262">
        <property type="entry name" value="CN_hydtase_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008990">
        <property type="entry name" value="Elect_transpt_acc-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50090">
        <property type="entry name" value="SSF50090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="113" mass="12685" checksum="A24792649BF99601" modified="2016-06-08" version="1">MADEIATLKHIAERNQVWPRMAAKYGVENPVPPWKSSLDGLCDALDHSACGDQVLTFKERRDEEDALSATVYADLPYPENQLMALAHSLLVRGVIDEGELQRRLEVVRARLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKH8</accession>
    <name>A0A132PKH8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851254.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12145"/>
    <dbReference type="EnsemblBacteria" id="KWX22841">
        <property type="protein sequence ID" value="KWX22841"/>
        <property type="gene ID" value="AFM11_18075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.971"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="2"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="426" mass="45717" checksum="975FC30C6FBB2062" modified="2016-06-08" version="1">MKVAVIGAGVVGVATAHALAERGHEVHVYDRRPQVATDTSASTGGLIAPGHSYTWASPGAPMMLLRSLAGRETSIRVRRADTALARWGLRFLRECTPSRSRANTLAKFELARYSQRLLDEIAHREGLEFNQTDKGVLYLYRSEPEFADAVGRSALLCDHGRQQKALDPEQIAAVEPALRHAAGEFAGAIHDTSDGTGDPHKFSTALAAAARRQGVEFHLSTAIDGLTTDGSTINGMRTADGVVRSDAVVLAAGSASPLLARDIGVYLPVYPAKGYSVTATIKDPDRAPALGGIDERYMVAWSPFGSELRMSATAEFVGYDRSAAPADYARILAAGDRLFPGAIDWTGAHYRTGLRPVTPDGPPLIGLGRHDNLYYNTGHGNVGWTMACGSARMLADLMDGRRPDIDPTPYSPVLRRRHRSHRGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKK7</accession>
    <name>A0A132PKK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18470</name>
        <name evidence="3" type="ORF">AWC31_12425</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851338.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22880">
        <property type="protein sequence ID" value="KWX22880"/>
        <property type="gene ID" value="AFM11_18470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18781">
        <property type="protein sequence ID" value="ORX18781"/>
        <property type="gene ID" value="AWC31_12425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1028"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="124" mass="13695" checksum="90604EE2686E1143" modified="2016-06-08" version="1">MRIGELARRTGVSQRSLRYYEQQGLLASDRTPGGQREYSERAVDRVIRIQELYAAGLTSRTIASLLPCMRDDGGPAPQATPRLLTELSAERTRLDRSIRELITSREVLDSVIAAAADPAAPRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKQ1</accession>
    <name>A0A132PKQ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diol dehydratase reactivation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_18970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15060"/>
    <dbReference type="EnsemblBacteria" id="KWX22592">
        <property type="protein sequence ID" value="KWX22592"/>
        <property type="gene ID" value="AFM11_18970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1128"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030994">
        <property type="entry name" value="DDR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040916">
        <property type="entry name" value="DDR_swiveling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028975">
        <property type="entry name" value="DDRA_swiveling_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08841">
        <property type="entry name" value="DDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18427">
        <property type="entry name" value="DDR_swiveling"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82317">
        <property type="entry name" value="SSF82317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDR_swiveling" evidence="3">
        <location>
            <begin position="104"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DDR" evidence="2">
        <location>
            <begin position="263"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="568" mass="59030" checksum="16BC72C4DBA6DA9E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKU5</accession>
    <name>A0A132PKU5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_16450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850629.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19870"/>
    <dbReference type="EnsemblBacteria" id="KWX22970">
        <property type="protein sequence ID" value="KWX22970"/>
        <property type="gene ID" value="AFM11_16450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.639"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="181" mass="18715" checksum="0785C3C20C6FE5C3" modified="2016-06-08" version="1">MTTNTTELTHTTPVSTMTDTGLLILRVATGATMLQAGLIKAFDFSTAAGFMESSGWRLPKFAAFMVTAAETLGGIGLLFGILTPLAACAVIGAMVDAWAVNVSADAFWSQPFNVPFLVAFAAAALLFTGAGTLSVDHRVFGRSRVSMPLAIGLLAVGVIAAVVTWIALNGVNPIHFTAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL44</accession>
    <name>A0A132PL44_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_17520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05040"/>
    <dbReference type="EnsemblBacteria" id="KWX22907">
        <property type="protein sequence ID" value="KWX22907"/>
        <property type="gene ID" value="AFM11_17520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.859"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="169" mass="18516" checksum="5D0DD950FD675686" modified="2016-06-08" version="1">MFAEKGYDATTVEDIAAAAGVSHMTFFRYFPRKEEVVEYDEYDPLIEDLIAARPADEPPLTAIHRAIRAGLQAILPTDHSALLQRTRLIMANPTLRARNTLAQDETRDLFARALARRAGMQAPDLRCVVQASAALATVAPAITAWAGADRQDLVALIDEAFAALRDAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM90</accession>
    <name>A0A132PM90_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Secretion protein EccB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_14310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849783.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09045"/>
    <dbReference type="EnsemblBacteria" id="KWX23456">
        <property type="protein sequence ID" value="KWX23456"/>
        <property type="gene ID" value="AFM11_14310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6970"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX23456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="480" mass="50908" checksum="B1B0656070A1A8B9" modified="2016-06-08" version="1">MAGFRLTTKVQVSGWRFLLRRVEHAIVRRDTRMFDDPLQFYSRAVFAGIVIAVLICLGAALMAYFKPLGKQGSDTLLVDRNTNQLYVMLPGSSQLRPVYNLTSARLALGNASEPVAVKSEELNRLPKGQSIGIPGAPYATPTGAPASRWSLCDTVAKPDSAAPEVEPSILIRSLSTDMSVGPMRADQGMLVAFEGANWLVTEGGRHSINLADRAVTSAVGIPVTAKATPISEGLFNALPNMGPWQLPQIAAAGAPNTLGLPANLVIGSVFQTATESDPQHYVVLADGVARVNDTTAAALRATNSYGLLEPPSVEASVVAKIAEQVYVSPLPDKPLEVMLRQDSPVLCWSWQREPGDQAPKATVIAGRRLPIPSTAIGSGIDQIDGDAVVYIEGGQFVRLQSPDPRVGESLYYIDPQGVRYGVANDDAAKTLGLSGAVNAPWQVVGLLVEGPVLSKEAALLEHDTLPADPNPRKVEGGQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMX3</accession>
    <name>A0A132PMX3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12925</name>
        <name evidence="3" type="ORF">AWC31_03210</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849139.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03210"/>
    <dbReference type="EnsemblBacteria" id="KWX23689">
        <property type="protein sequence ID" value="KWX23689"/>
        <property type="gene ID" value="AFM11_12925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11148">
        <property type="protein sequence ID" value="ORX11148"/>
        <property type="gene ID" value="AWC31_03210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6677"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="284" mass="33007" checksum="3D609CDBE21CEBA6" modified="2016-06-08" version="1">MTELAEQPQQLDALPLGPESLVWKYFGDNRMYLIGPRPAVLQNMLAELGQGVLDHSTFFSDTAERLKRTIPPIFRTVYGSDDDNAGTQVRDFHHHVKGDMPDGGRYHALDPETYFWAHATFVEQVLYFADTFVKRLTDAEKEQIYLESKTWYRRYGVSDRPMPATYAEFVQYWDRMMDEVAVPHKSARYGVGYVTKGFPCPKAVHPAVWRVIAFVFNPVAAFLTTGGLPPRARDLLELPWTERQERNYQRFAAFWRSRPVNWVWDHLPMSVRYNKFAQKGYARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNE6</accession>
    <name>A0A132PNE6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29805"/>
    <dbReference type="EnsemblBacteria" id="KWX23850">
        <property type="protein sequence ID" value="KWX23850"/>
        <property type="gene ID" value="AFM11_13920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6880"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="194"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="32673" checksum="871F7D541E80340A" modified="2016-06-08" version="1">MKFAQAGSELLLMARSVWDGKRPRTPRTMLSNTGFTAGGVDFRFVSERIAAPTDWCFEEPHHVVVVHRGGRMQSMEIEFERGPSGRTVPQVGDVWVIPAGHRYAALAQGNTVHFCELRIPTALLGDRELMPRIRHRDPLVHQLIERMGSAVGRTDVFARLFTESLAETLRLHLTDQFAVLRATRSAGLSRAARSRLIEYLDDSLDSEITLTTLAELTDMTVADFTKAFTAAFNTTPYQFVLDRRIARAKTMLATTTVSITDISTAVGFSTPSHFATTFKNRVGVTPSDYRRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNL2</accession>
    <name>A0A132PNL2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23920">
        <property type="protein sequence ID" value="KWX23920"/>
        <property type="gene ID" value="AFM11_11110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6299"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="296" mass="31371" checksum="2C00FCEE16D9F003" modified="2016-06-08" version="1">MLVAVDQHGSITAAAKALHMTPSAISQQLKVLSTEAKATIVEALPTGVRCTPAGKLLVSHAIRILDELKQAEHSLAELSGQEIEEIRFACFPAATDSLVPEILRIIATQHPTAALSFDVMRSPVALRALCDGTVDAALVARYPDDPAPGRDLRMVELGNDLLVAAMPTEHPLTHGQSVPLRRLTDIPLLLESSASPFCQLFLTACADAGITPQIRAWSPQANVALDMVAHGVGIALLPAMTIDSIPAGIVAAPLSPVIKRTVTLAFRASTERSRVTDALVSSSREAARTKLSYNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNN7</accession>
    <name>A0A132PNN7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11275</name>
        <name evidence="2" type="ORF">AWC31_30620</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848143.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30620"/>
    <dbReference type="EnsemblBacteria" id="KWX23951">
        <property type="protein sequence ID" value="KWX23951"/>
        <property type="gene ID" value="AFM11_11275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12349">
        <property type="protein sequence ID" value="ORX12349"/>
        <property type="gene ID" value="AWC31_30620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6332"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX12349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="98" mass="11104" checksum="9FB8E537ED31C33B" modified="2016-06-08" version="1">MSSTTEFAELHNLIGDMRRCVTTLASKYGDSPAMRRVVNDAERILNDIERLDIDAEELEMRHGVTRQRQGAEKIAIPDTQYGSDFWQDVADEGLGGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPB2</accession>
    <name>A0A132PPB2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_12210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848651.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09765"/>
    <dbReference type="EnsemblBacteria" id="KWX24114">
        <property type="protein sequence ID" value="KWX24114"/>
        <property type="gene ID" value="AFM11_12210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6521"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="407" mass="41493" checksum="D1C631809866E7F5" modified="2016-06-08" version="1">MTVESPTTASPWTLRVTVQLTVLAAAAFVYVTAEILPVGALPAIAADLDVSEGLVGTLMATYALVAALTTVLLVRVTAHWPRRRTLLLTLVCLTVSQIISALAPNFAVLAGGRVLCALTHGLMWSVIAPIGARLVPPSHAGRATAAVYVGTALALVVGNPLTAALSALWGWRFAVVAVAVTAFAVTLAAWATLPAMPSTQDVAAAPRKHRRNRRLITLSALTLVGVTGHFIAYTFIVVIIRDVVGVHGAHLAWLLAGYGVAGLLAMAAMARPLDHWPKASVVGCLAALAAALTALTGLAVDQRPGLATVLVGALAVVLWGAASTALPPMLQASAMRSAPDDPDGASGLYVAAFQVGIMGGALIGGGIYDHGGLAAMVGTAAALIIVAMSGVLATRGLFRVPYATSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPC4</accession>
    <name>A0A132PPC4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13300</name>
        <name evidence="3" type="ORF">AWC31_03585</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849603.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03585"/>
    <dbReference type="EnsemblBacteria" id="KWX23882">
        <property type="protein sequence ID" value="KWX23882"/>
        <property type="gene ID" value="AFM11_13300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11321">
        <property type="protein sequence ID" value="ORX11321"/>
        <property type="gene ID" value="AWC31_03585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6753"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="128" mass="13855" checksum="043DA2936B0FE6C4" modified="2016-06-08" version="1">MIDHFGINCADFAKAKEFYDAVLGVLGYTRQMDFGVAIGYGKDGHPAFWIADASAGDAAGPNREIHVAFHASGVDAVTEFYETALKLGVESLHAPRLWPEYHPGYFGAFVRDPDGNNVEAVFHGAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPD0</accession>
    <name>A0A132PPD0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_11890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848482.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10080"/>
    <dbReference type="EnsemblBacteria" id="KWX24057">
        <property type="protein sequence ID" value="KWX24057"/>
        <property type="gene ID" value="AFM11_11890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6457"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="252"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="340" mass="36942" checksum="069F7E1ECDD7B70B" modified="2016-06-08" version="1">MLEPATTQAEGFVPLRVKQVVRETSDAVSLVFDRPPGGAAEFRYLPGQFLTLLVHVDGQEHRRCYSMSSSPALDEDLQITVKRDRDGVVSNWLNNTAAPGDELHAAPPQGRFVMREQERDLVAFAGGSGITPVYSLLRSALETTGRGARLFYANRSRDSIIFEKSLAALREGHPDRFTLCHHLDDEKGLVTAEQVETFIAEVADADFYVCGPGPFMDTVKKALLSAGVSADRLHLERFTVAAAPVETATVTEEVTIELDRRSATLAYRPGHTLLQTARMGGLRAPSSCETGSCGTCIAQITEGSARMLNNDALDDDEVADGLVVTCQALPTSRTVKVVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPE6</accession>
    <name>A0A132PPE6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ORF">AFM11_09475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05750"/>
    <dbReference type="EnsemblBacteria" id="KWX24218">
        <property type="protein sequence ID" value="KWX24218"/>
        <property type="gene ID" value="AFM11_09475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5932"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="203" mass="22408" checksum="3905FE7F55C48A06" modified="2016-06-08" version="1">MGGTFDPIHNGHLVAASEVADLFDLDEVVFVPTGQPWQKHDRRVTEAEDRYLMTVIATASNPRFSVSRVDIDRGGPTYTKDTLRDLRDLNADADLYFITGADALASILSWQNWEDLFSMARFVGVSRPGYELDGKHISAALQELPPDALKLVEVPALAISSSDCRRRAEQARPIWYLVPDGVVQYVAKRGLYTADATNAGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPG8</accession>
    <name>A0A132PPG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847185.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05650"/>
    <dbReference type="EnsemblBacteria" id="KWX24238">
        <property type="protein sequence ID" value="KWX24238"/>
        <property type="gene ID" value="AFM11_09575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5952"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025327">
        <property type="entry name" value="DUF4233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14017">
        <property type="entry name" value="DUF4233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="129" mass="13702" checksum="904954971AD9CB79" modified="2016-06-08" version="1">MSTSPTPPDPWKSFRGVMAGTLILEAIVVLLALPVVAVGESGLTWTAGGYLIGLAVVLILMCGVQGRPWAIWANLGIQVVLIAGVVIHGAIGFIGVVFAVVWLLIVYLRAEVKRRQERGLLPGQQPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPJ5</accession>
    <name>A0A132PPJ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_09510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847141.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05715"/>
    <dbReference type="EnsemblBacteria" id="KWX24225">
        <property type="protein sequence ID" value="KWX24225"/>
        <property type="gene ID" value="AFM11_09510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5939"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="PTHR31937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX24225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="200" mass="21052" checksum="1FDA92738CA00A64" modified="2016-06-08" version="1">MVTATRQDALARRIRWLVAATITYNVIEAAIALAEGTRVSSSALIAFGLDSAVEVSSAAVVAWQFAAADPETRERTALRLIAFSFFALAAYVTVDATMSLFGIGEARHSPVGIALATASLLIMPVLSLTQRRAARELGSRSAFADSKQTLLCTYLSAALLVGLLLNALLGWAWADGVAALVIAALAVREGLNAWRGDPCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPM0</accession>
    <name>A0A132PPM0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847203.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24243">
        <property type="protein sequence ID" value="KWX24243"/>
        <property type="gene ID" value="AFM11_09605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5958"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453475" evidence="1">
        <location>
            <begin position="33"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="203" mass="20975" checksum="B15DAFDA713E8B01" modified="2016-06-08" version="1">MNPTRFGVAIGAAVIAASALSGCSKVTEIRDAASNAAEQVVASGTEKITEAVSGNLFTAEGIDAAYAAISEKVGANPMQVVEINIAPGVLTVEAIDPNAPTELNQWSYTSGAVGPSRPIDYDDDTEALQQNLFAITDVPTTAIANAINGAVAASQIPDGKVQTLSIKRNIPFEANVLMFINVEGERSSKQVRADSAGQITDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ15</accession>
    <name>A0A132PQ15_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_10765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847786.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19280"/>
    <dbReference type="EnsemblBacteria" id="KWX24430">
        <property type="protein sequence ID" value="KWX24430"/>
        <property type="gene ID" value="AFM11_10765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6192"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="388" mass="42749" checksum="10EA7CB32FEFF6C7" modified="2016-06-08" version="1">MNFELTEDQELIRKSVAELAGKFDDHYWMTKDQAHEFPQEFYDAIAGGGWLGMTIPEEYGGHGLGITEATILAEEVARSGGGMNAASAIHMSIFGMQPVVVFGSDAMKAETLPRIVNGDLHVCFGVTEPGAGLDTSRITTFAKRDGDSYLVNGRKVWISKALESEKILLLTRTTPRDEAAKPTDGLTLFLTDLDRDHVDIRPINKMGRNAVSSNELFIDDLRVPAEHRIGEEGKGFKYILHGLNPERMLIAAEALGIGRVALDRAVKYANERVVFDRPIGMNQGIQFPLADSLARLDAAELILRKATWLYDNGKPCGREANMAKYLCADAGFAAADRALQTHGGMGYSEEYNISRFFRESRLMKIAPVSQEMILNFLGANVLGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ16</accession>
    <name>A0A132PQ16_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_10750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847780.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19265"/>
    <dbReference type="EnsemblBacteria" id="KWX24428">
        <property type="protein sequence ID" value="KWX24428"/>
        <property type="gene ID" value="AFM11_10750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6189"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="260"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="382" mass="39774" checksum="210F506CC64AA747" modified="2016-06-08" version="1">MRETVIVEAVRTPVGKRNGGLSGMHAADLSALVLNALVERAGISPEIVDDVVWGCVSQVGDQSSNIGRYSVLAAGWPEHIPGTTVNRACGSSQQALDFAVQAVMSGQQDVVVAGGVEVMSRVPLGAARATGQPYGPKVLDRYRDFSFNQGISAELISQKWGFDRTRLDEYSAASHERAAAAQDAGAFETQMITVFPDDGDPVIADEGVRRGTTVEKLAGLKPAFTEDGVIHAGNSSQISDGAAALLVMTAENAVTMGLSPIVRYRAGAVTGADPVLMLTGPIPATEKVLRKAGVGLDEIGVFEVNEAFAPVPLAWLAETGADEAKLNPLGGAIALGHPLGASGAVLMTRMINHMRDKGIRYGLQTMCEGGGTANATIVELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQZ2</accession>
    <name>A0A132PQZ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_08770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846605.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13600"/>
    <dbReference type="EnsemblBacteria" id="KWX24743">
        <property type="protein sequence ID" value="KWX24743"/>
        <property type="gene ID" value="AFM11_08770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5602"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="209" mass="22672" checksum="E355BCCB92D45A81" modified="2016-06-08" version="1">MIEVTAAVTPKGERRRYALVKAAADLLCEGGFDAVRHRAVARRAGLPLASTTYYFSSLDDLIAKAVEYIGTREAEQLQAGVAALSRRRRGAESTADILVDLLVGESPESRITEQLISRYERYIACARQPGLRDIQRRILQQRTDAVVEVVERSGRSVRAELVTALVCAVDGAVVASLVDDGDGPRASARATLIDVIDVLAPVDERAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR40</accession>
    <name>A0A132PR40_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09090</name>
        <name evidence="3" type="ORF">AWC31_13280</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846781.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13280"/>
    <dbReference type="EnsemblBacteria" id="KWX24796">
        <property type="protein sequence ID" value="KWX24796"/>
        <property type="gene ID" value="AFM11_09090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18293">
        <property type="protein sequence ID" value="ORX18293"/>
        <property type="gene ID" value="AWC31_13280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5667"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="266" mass="28608" checksum="B01895704F786E1E" modified="2016-06-08" version="1">MSEAKKEPDALIEQRGHTLILTLNRPEARNALSTEMLSIMVAAWDRVDNDPEIRTCILTGAGGYFCAGMDLKGATKKPPGDSFKDGSYDPSRIDGLLKGRRLTKPLIAAVEGPAIAGGTEILQGTDIRIAGESAKFGISEAKWSLYPMGGSAVRLVRQIPYTIACDLLLTGRHITAAEALSYGLIGYVVPDGTALDKALEIAEVINNNGPLAVQAILKTIRETEGMHENEAFKPDTANGIPVFLSEDAKEGPLAFKEKRAPKFQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR57</accession>
    <name>A0A132PR57_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_08840</name>
        <name evidence="2" type="ORF">AWC31_13530</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846642.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13530"/>
    <dbReference type="EnsemblBacteria" id="KWX24754">
        <property type="protein sequence ID" value="KWX24754"/>
        <property type="gene ID" value="AFM11_08840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18336">
        <property type="protein sequence ID" value="ORX18336"/>
        <property type="gene ID" value="AWC31_13530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5616"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="275" mass="29333" checksum="31CCDBF4E38B6546" modified="2016-06-08" version="1">MPRFEPLPDRRPALVAGASSGIGEATAIKLAANGFPVALGARRMEKLEEIVGKIRADGGEAIAVHLDVTDPDSVKAAVEQTTSELGDIEVLVAGAGDTYFGKLDSISTEQFESQVQIHLIGANRVATAVLPGMIERRRGDLIFVGSDVALRQRPHMGAYGAAKAALVAMVTNYQMELEGTGVRASIVHPGPTKTSMGWSLPAELIGPALEDWAKWGQARHDYFLRAADLARAITFVAETPRGGFIANMELQPEAPLAEVKDRQKLALGEEGMPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRD7</accession>
    <name>A0A132PRD7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="6">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serC</name>
        <name evidence="8" type="ORF">AFM11_07990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="6">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846224.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24590"/>
    <dbReference type="EnsemblBacteria" id="KWX24612">
        <property type="protein sequence ID" value="KWX24612"/>
        <property type="gene ID" value="AFM11_07990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5448"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006272">
        <property type="entry name" value="Pser_aminoTfrase_mycobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01366">
        <property type="entry name" value="serC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="40"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="370" mass="39294" checksum="286FDB592D7AF42B" modified="2016-06-08" version="1">MAELTIPADLKPRDGRFGCGPSKVRPEQLSALAAAGDLFGTSHRQAPVKNLVGRVRDGLRQLFSLPDGYEVILGNGGSTAFWDAAAFGLIDKRSLHLTYGEFSSKFASAVAKNPFIGDPIVVKSDPGTAPEPQSDPSVDVIAWAHNETSTGVAVPVRRPAGSDDALVLIDATSAAGGLPVDITDVDAYYFAPQKNFAGDGGLWLAVMSPAALARIEAIAASDRWVPDFLSLPIAVENSVKNQTYNTPAIATLILLAEQLDWLNGNGGLEWAVKRTADSSQRLYSWAEAASFATPFVTDPALRSQVVGTVDFSDDVDAAAVAKVLRANGIVDTEPYRKLGRNQLRIGMFPAVDPDDVSALTSCVDWVVENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRD8</accession>
    <name>A0A132PRD8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09080</name>
        <name evidence="3" type="ORF">AWC31_13290</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847006.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13290"/>
    <dbReference type="EnsemblBacteria" id="KWX24865">
        <property type="protein sequence ID" value="KWX24865"/>
        <property type="gene ID" value="AFM11_09080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18295">
        <property type="protein sequence ID" value="ORX18295"/>
        <property type="gene ID" value="AWC31_13290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5665"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="9"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="373" mass="39306" checksum="48EF8969DE787331" modified="2016-06-08" version="1">MRTELCDRFGIEYPIFVFTPSEKVAAAVSKAGGLGVLGCVRFNDADDLENVLQWMDANTDGKPYGVDVVMPAKVPTEGTAVDINKLIPQSHRDFVAKTLADLGVPPLPEDEERNEGVLGWLHSVARSHVEVALKHPIKLIANALGSPPNDVIEQAHAAGVPVAALAGSAKHALRHVENGVDIVVAQGHEAGGHTGEIGSMVLWPEIVDALDGKAPVLAAGGIGTGKQVAAALALGASGVWMGSAFLTSAEYDLGHRLPGGTSTIQEALLRAGTADTVRRKIYTGKPARLLKTKWTDAWDAPDAPEPLPMPLQNILVSEAHQRMNESDNPDTVSMPVGQIVGRMNEIRPVADIIGELVAGFEQATKRLDGIAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRG2</accession>
    <name>A0A132PRG2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_05410</name>
        <name evidence="11" type="ORF">AWC31_12785</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844979.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12785"/>
    <dbReference type="EnsemblBacteria" id="KWX24885">
        <property type="protein sequence ID" value="KWX24885"/>
        <property type="gene ID" value="AFM11_05410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18832">
        <property type="protein sequence ID" value="ORX18832"/>
        <property type="gene ID" value="AWC31_12785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4271"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX18832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="118" mass="12934" checksum="B76CAEF1265A447A" modified="2016-06-08" version="1">MDLVIFLPLLIIMGAFMFFASRRQKKAMQATIDLHNSLQIGDRIHTTSGLQGTITGITDDNIDLEIAPGVVTTWMKLAVRDRIESDTDDSYDDDDATPAATELTESTGVTDTDGLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRL8</accession>
    <name>A0A132PRL8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845149.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11785"/>
    <dbReference type="EnsemblBacteria" id="KWX24973">
        <property type="protein sequence ID" value="KWX24973"/>
        <property type="gene ID" value="AFM11_05925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4376"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019283">
        <property type="entry name" value="DUF2330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10092">
        <property type="entry name" value="DUF2330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453528" evidence="2">
        <location>
            <begin position="24"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="351" mass="37793" checksum="EE0B82EA6839D778" modified="2016-06-08" version="1">MLRALLVMVFVGLSANIAAPAWACGCGAYIPDNDDAAVVDERALITWDGTTQDILMSFNVRGGSQKAAWVMPVPTASHVTAGDGAVFEELARLTAPRIEYRDSWWPTFGWLGGFAAAEGGADRAPAGADVSVLGQQRIGPFAITRLAADDPAALADWLADNGFPQPPDLARNIAPYVAEGWEIVAIRLTPDTAEAELTGNLQPLRLSFASGKVVYPMRLSRSAKVPQAVDLYVIAEHRMDPVEYPVAGERPTLEFAGPVAAESVAYTLRPYLESGAYLTRWSDDISRPESIDGDYVFERADSDAAFQKVVHEYRDHGDITGFFLLAGSALAAISTIVAVLIVWVGRARQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRT7</accession>
    <name>A0A132PRT7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ctaB</name>
        <name evidence="8" type="ORF">AFM11_06260</name>
        <name evidence="9" type="ORF">AWC31_29415</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845249.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29415"/>
    <dbReference type="EnsemblBacteria" id="KWX25030">
        <property type="protein sequence ID" value="KWX25030"/>
        <property type="gene ID" value="AFM11_06260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13893">
        <property type="protein sequence ID" value="ORX13893"/>
        <property type="gene ID" value="AWC31_29415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4446"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX13893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="308" mass="33850" checksum="BD3FCDBEA94C70DD" modified="2016-06-08" version="1">MSIRERRLIGEAPSRIRSTFLAYLALTKPRVIELLLVTAIPAMLLADRGTVDPLLILNTLVGGMLAAAGANTLNCVADADIDKVMKRTARRPLARASVPTRHALIFGLVLSVGSFCWLWWTTNLLSGLLAIATILFYVFVYTLLLKRRTSQNVVWGGAAGCMPVMIGWSAVTGTIQWPALVMFAIIFFWTPPHTWALAMRYKDDYKAAGVPMLPAVATERQVTRQILIYTWLTVLTTLVLALATGWLYGAVALLAGAWFLVMAHQLYSGVKRGEPVKPLRLFLQSNNYLAVVFCALAIDSALALPTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRX7</accession>
    <name>A0A132PRX7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_06685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845383.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28990"/>
    <dbReference type="EnsemblBacteria" id="KWX25101">
        <property type="protein sequence ID" value="KWX25101"/>
        <property type="gene ID" value="AFM11_06685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4536"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="9">
        <location>
            <begin position="202"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="3">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604550-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="314" mass="31876" checksum="2E4CB3E45BFC085E" modified="2016-06-08" version="1">MTRAADIVVITTGGTISTSTDSAGVRRPTLHGADLMAGLPTAGNVQVIDLMTVDSALLGPAEWDRIRAAVATAAETADGVVVTHGTDTMEETALWLELTYAGSVPVVLTGAQRGSDAPDSDGPANLRDALVVASSPRARGLGVVVSFAGAVWQPLGMRKRSTSDLAAFTGSRLGTVDRDGLEVSAQKTRPFLGALVAADAPRVDTVATFPGADTAALAGVAAGARGIVLEAMGSGNAGTSLIDGVRRHCRGGVVVAVSTRVPDGPVRPEYGPGRDLVDAGAVVMSRLRPAQARVLLMAALASGRPVAEIVDVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS15</accession>
    <name>A0A132PS15_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_06900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845488.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28750"/>
    <dbReference type="EnsemblBacteria" id="KWX25141">
        <property type="protein sequence ID" value="KWX25141"/>
        <property type="gene ID" value="AFM11_06900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4579"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="390"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="539" mass="56699" checksum="143F845455413DB3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS29</accession>
    <name>A0A132PS29_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06530</name>
        <name evidence="3" type="ORF">AWC31_29145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845336.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29145"/>
    <dbReference type="EnsemblBacteria" id="KWX25074">
        <property type="protein sequence ID" value="KWX25074"/>
        <property type="gene ID" value="AFM11_06530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13850">
        <property type="protein sequence ID" value="ORX13850"/>
        <property type="gene ID" value="AWC31_29145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4500"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="54"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="314" mass="34433" checksum="A947010BD78676A0" modified="2016-06-08" version="1">MTSSRRAVDLPSLKRGEIRDPALTAALRKLELTVRRKLDGVLHGDHLGLIPGPGSEPGESRIYQPGDDVRRMDWSVTARTTQPHVRQMIADRELETWLVVDVSASLDFGTTGCEKRDLAVAAAAAIAFLNSGGGNRIGAIIANGDTMRRVPALSGRVHEQELLRAIATTPKAPTGVRGDLAAAIDALRRPERRRGMAVIISDFLGPINWMRPLRAIAGRHEVLGIEVLDPRDVELPDVGDVILQDTETGVTREFTIDAQLRSDFEQAAAAHREEVARTLRRCDAPLLTLRTDRDWIADVVRFVANRRRGALAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSC1</accession>
    <name>A0A132PSC1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06345</name>
        <name evidence="3" type="ORF">AWC31_29330</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29330"/>
    <dbReference type="EnsemblBacteria" id="KWX25251">
        <property type="protein sequence ID" value="KWX25251"/>
        <property type="gene ID" value="AFM11_06345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13959">
        <property type="protein sequence ID" value="ORX13959"/>
        <property type="gene ID" value="AWC31_29330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4463"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="236" mass="24857" checksum="4378440FAB6B6CEC" modified="2016-06-08" version="1">MPVSDGQTRRAIIQLLLEGPITAGQIGDRLGISAAGVRRHLDALIDAGDAQASAAAAWQHNGRGRPAKRYRLTAAGRAKLGHTYDDLAVAAIRQLREIGGKDAVRTFARRRIDTILAGVTGGSDDVAETADRVADALTKAGYATTTTPVSGPVHGVQICQHHCPISHVAEEFPELCETESEAFAEILGTHVQRLATIVNGDCACTTHVPLDTDNSTDVRGTARPRTTTAINQGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSN8</accession>
    <name>A0A132PSN8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844089.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21570"/>
    <dbReference type="EnsemblBacteria" id="KWX25368">
        <property type="protein sequence ID" value="KWX25368"/>
        <property type="gene ID" value="AFM11_03585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2592"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453554" evidence="1">
        <location>
            <begin position="16"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="64"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="319" mass="33643" checksum="56B11850591A94D2" modified="2016-06-08" version="1">MFSRILRIVFVLAMAATAVACSGNDSRPGGYTLRIGATSVTGTPAGSLGWGDREGILAEQLKAAGVDKIEYSFFQSGSDVVSALFAGAIDVAAVGDNPALRARSRDAKVVLLSLDSINGDAWIVGAKGGPTDIQGLVDKSVTAPQGTIRDRAARQLIDTAGLTGKIQVRDVPTPESIAGLSSGQIDATVVTGASAIELQSKGFPVIDSLSRHGFGSTGTNITLTSFTDQHPEFAGAWQQAVTAVNRDINENFDDYLAWVAETDGTELEFVQKSTRAEEFNTEPFPEVGLNQLEAAYNFLNADGSFDNEYSVREWAGAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSR2</accession>
    <name>A0A132PSR2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844036.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21680"/>
    <dbReference type="EnsemblBacteria" id="KWX25350">
        <property type="protein sequence ID" value="KWX25350"/>
        <property type="gene ID" value="AFM11_03470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2568"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="32370" checksum="FA47AD366EAC72F4" modified="2016-06-08" version="1">MRFTYAEAMTDPTYYIPLAKAAEAAGYHAMTIPDSVAYPFESDSKYPYTPDGNREFLDGKAFIEAFVLASALCAATTTLKFNFFVLKLPIRPPALVAKQAGSLAALFDNRLGLGVGTSPWPEDYELMDVPFAKRGKRMDECIDIIRGLTTGEYFEYHGEFYDIPKTKMTPAPSKPVPILIGGHADAALRRAARCDGWMHGGGSPEELDQLLGRLNKFRQEEPEAARTDDFQIHVISADAFTVDGIKRLEDKGVTDVIVGFRIPYIMGEDTEPLDKKIRNLEWFAENVIAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT19</accession>
    <name>A0A132PT19_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_03885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844247.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21280"/>
    <dbReference type="EnsemblBacteria" id="KWX25414">
        <property type="protein sequence ID" value="KWX25414"/>
        <property type="gene ID" value="AFM11_03885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2655"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="141"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="199" mass="21296" checksum="FD8424B58476E77B" modified="2016-06-08" version="1">MVEVVVQRTKNQLRAALLRKRRGLAQHIRDAEATALRGWLPALVAHGQTVCAYVPVGSEPGSPAMLDTLLNLGVRVLLPIARNDSDGVPMPMQWGTYRPGGLLDAEFGLREPPPPWLPAEAAGEADVILVPALAVDRSGSRLGRGAGFYDRTLGCVAADARLVAVVRDEELLDELPAEPHDVRMTHALTPDGGIVPLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTA5</accession>
    <name>A0A132PTA5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_04745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844613.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20400"/>
    <dbReference type="EnsemblBacteria" id="KWX25550">
        <property type="protein sequence ID" value="KWX25550"/>
        <property type="gene ID" value="AFM11_04745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2830"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="27335" checksum="66E1EC0ECB0F3708" modified="2016-06-08" version="1">MSDFETILVTRTGRVATITLNRPKALNALNSQVMTEVTTAAAELDKDPGVGAIIVTGNEKAFAAGADIKEMAELSFADVYSADFFELWSKFAATRTPTIAAVAGYALGGGCELAMMCDILIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTIDATEAERAGLVSRLVPADSLIDEALAVAETIAGMSLSASRMAKEAVNRAFESSLTEGLLYERRLFHSAFATADQKEGMTAFTEKRAANFTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTE4</accession>
    <name>A0A132PTE4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25590">
        <property type="protein sequence ID" value="KWX25590"/>
        <property type="gene ID" value="AFM11_04980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2877"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="451" mass="46682" checksum="305DF31442D98F82" modified="2016-06-08" version="1">MSALLDDLAGAVSTLVTDPAAMEGYRRDQCLLTEAGRPAAVVIAKALEEVAATVRVARKHRVPLVTRGAGTGLAGAANAIDGCIVLVLSRLDRILAIDPIARSAVVQPGVLNGDLDRAAAAHGLWYAPDPGSRAISTIGGNLATNAGGMCCAKYGVTADHVQQLTAVLGTGETVHTGALTRKNVAGLDLTRLLVGSEGTLGIIVEATVRLRRRPAAVATVAASFPTAQDAIATVLELGDGAAAVELMDRTTVRAVNAATRMNLDEHAGAVMLAQFDGADDTAVGAQAQHCAVLAESRGAEVFHTVDIAEGEALMEARRAAYPALERLGATLLDDVAVGAHRMPALLAQIEQIAARYDVIIGTFGHAADGNLHPTIVFDPADSGQRDRARMAFDDIVAAAIEHGGTISGEHGIGVLKQDMLDRQVGSVELALMHRIKAAFDPDGILNPGRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTR2</accession>
    <name>A0A132PTR2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842027.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33135"/>
    <dbReference type="EnsemblBacteria" id="KWX25729">
        <property type="protein sequence ID" value="KWX25729"/>
        <property type="gene ID" value="AFM11_00030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="312" mass="33757" checksum="598D11274A39F3B5" modified="2016-06-08" version="1">MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPDKGNAIVADTPLELSALVERADLDPNVHVILVSGRGEGFCAGFDLGAYAEGSSSAGGGNPYRDTVLSGKTQAINHLPDQPWDPMIDYQMMSRFVRGFSSLMHADKPTVVKIHGYCVAGGTDIALHADQVIAAADAKIGYPPMRVWGVPAAGLWAHRLGDQRAKRLLFTGDCITGAQAAEWGLAVEAPEPEDLDERTERLVARIAAMPVNQLIMAKLACNSALLQQGVATSQMVSTVFDGIARHTPEGHAFVADAREHGFREAVRHRDEPLGDYGRKTSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTR3</accession>
    <name>A0A132PTR3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842021.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25728">
        <property type="protein sequence ID" value="KWX25728"/>
        <property type="gene ID" value="AFM11_00020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="377" mass="40075" checksum="DDE505D9B3E6B6B5" modified="2016-06-08" version="1">MPAIDAVRPVGGPVWVAWREGTLTRAYELETLVDYLALGNARDVGGSLSRAIKSHLDAARDAAGGKRPELGKRIRLSRNGPLLERAMSNLDAAEAQLLNLAPPSYLAGQLPSLLRHVQRHLRSSDPGRQAMERLAKTLITTDRGSIAPVVEQERDTIVSTVRAASSEALRENVRLRSFRNIVVSTTLVLTVLVIALAIIGYNDPKLIPLCFAPEDANEVTVVCPTAESVPFAPVRAGVDPPEEGAIETGAKVAETAGKWDLAVVALVGLVAAAIASAATLSHVKGSSERYGIPVALAALKLPTGALTAVLGILLMRGQFVPGLNALDTPAQILAWALVFGYAQQIFTRLIDQQGQTVLNSVRSTEDSPAPDHKRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTU6</accession>
    <name>A0A132PTU6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_00210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842121.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33320"/>
    <dbReference type="EnsemblBacteria" id="KWX25759">
        <property type="protein sequence ID" value="KWX25759"/>
        <property type="gene ID" value="AFM11_00210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.43"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="27"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="524" mass="54620" checksum="DE5375DEC6BA1344" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTU9</accession>
    <name>A0A132PTU9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_00150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842077.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33260"/>
    <dbReference type="EnsemblBacteria" id="KWX25750">
        <property type="protein sequence ID" value="KWX25750"/>
        <property type="gene ID" value="AFM11_00150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.31"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="82"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="217"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="334"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="440" mass="46298" checksum="4363DA200E3AB6BD" modified="2016-06-08" version="1">MRNSHDPLTVLSDGELPVAPDPEFAARLRARLESALTLPNRTEGVVMTGTDTAIAELNEPATAASAPRPASAPRPAATSTPRPAAIPYLAVPDARTAIAWYIEALGAVQVGEPIVMDDGRIGHAELAIGGGVLYLADEYPEIGLRAPAPQANSVSLMLHVPDTDAALERARTRGAHVQREPYENYGTRNAAIIDPSGHRWMLSGPATGSATPIQHGDVGYVSVWVPDAARAAAFYGHVLGWTYDAATGQVTNTKQHIGIFSVAGRPTMFCCYAVTDLDGARQAIAAGGGQPGQIQEFDFGTVLDATDPAGTPFAVFEPKAGTPRPELNGAGPGELSYITYEVPDSAAFEAFYSRVLFWTFEPGRIDDGWGVQGSQPMSGMAGGAAAATTVPMWTVADVEAAVERVREAGGTVLQEPAQQPYGFTAMCADDQGGRFYLGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU70</accession>
    <name>A0A132PU70_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00925</name>
        <name evidence="3" type="ORF">AWC31_33955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842498.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33955"/>
    <dbReference type="EnsemblBacteria" id="KWX25886">
        <property type="protein sequence ID" value="KWX25886"/>
        <property type="gene ID" value="AFM11_00925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11687">
        <property type="protein sequence ID" value="ORX11687"/>
        <property type="gene ID" value="AWC31_33955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.191"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="60" mass="5945" checksum="081EA2468D8B68EC" modified="2016-06-08" version="1">MNQKYVVIGLFAGLLLAIAAVTGGLIGFLLALVLGGGGAAIGAHLDGTIDLTALGRRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUE9</accession>
    <name>A0A132PUE9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_03555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844863.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21600"/>
    <dbReference type="EnsemblBacteria" id="KWX25672">
        <property type="protein sequence ID" value="KWX25672"/>
        <property type="gene ID" value="AFM11_03555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2586"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="16"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="309"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="690"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX25672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="773" mass="85598" checksum="4FF40D54B55D2965" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUH5</accession>
    <name>A0A132PUH5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">nnrE</name>
        <name evidence="14" type="synonym">nnrD</name>
        <name evidence="18" type="ORF">AFM11_01150</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
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        <property type="gene ID" value="AFM11_01150"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
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            <end position="66"/>
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            <end position="129"/>
        </location>
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        <location>
            <position position="63"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
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        </location>
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        </ligand>
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        <location>
            <position position="149"/>
        </location>
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            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
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        <location>
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            <dbReference type="ChEBI" id="CHEBI:29103"/>
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            <end position="383"/>
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            <name>AMP</name>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="470" mass="47035" checksum="A6F24C2DF010FAE0" modified="2016-06-08" version="1">MRHYYSADAIREAEAPLLASLPDGALMRRAAYGLATAVGRELRARTGGIAGRRICAVVGSGDNGGDALWAATFLRRRGAAVDAVLLNPDRTHPEALAAFRSAGGHVVQNIGTATDLVIDGVVGISGRGPLRPDAEAVFAANAAPVVAVDIPSGVDVQTGAADGPYVRAAVTVTFGGLKPVHALGECGRVELVDIGLDLAPTDLIGFEAVDVKARWPVPGPRDDKYTQGVTGVLSGSATYPGAAVLSTGAAVAATSGMVRYAGSAAAQVLSHWPEVVAAPSPQEAGRVQAWVVGPGLGTDDTAKAALRFALESDLPVIADADALTLLAADSGPVTDRSAPTVLTPHAGEYQRLAGVPVGADRVAATRDLAERLGVTVLLKGNVTVIAQPGAATYLNPAGQSWAATAGSGDVLSGIIGALLAAGLPSGEAAAAAAFVHARAANLSAADPGPNPAPTSASRILAHVRGAIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUJ2</accession>
    <name>A0A132PUJ2_9MYCO</name>
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        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AFM11_00640</name>
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    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="AFM11_00640"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="133" mass="14652" checksum="B13D1956DE9033C8" modified="2016-06-08" version="1">MTDVLPPDGPPTGTHLVRLARMIGAVIERHLADEDLTLDDWLVLEALGTAPGLTMAELRAQTLTAAPTLTRVVDRLVARALVFREVDADDRRKVRVNLSKRGAALHARLLSTIRPAEQAWFDQHGASAWMVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUW1</accession>
    <name>A0A132PUW1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Primosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843090.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34910"/>
    <dbReference type="EnsemblBacteria" id="KWX26064">
        <property type="protein sequence ID" value="KWX26064"/>
        <property type="gene ID" value="AFM11_02130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.436"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="423" mass="46248" checksum="9C9A5468F7BA0E58" modified="2016-06-08" version="1">MAADIVPVRLGLTKGDLYTLWAPRWRDAGDEWEAFLGKDDDLYAFESVADLAAFVRTNSDNDLTDHPAWEKLTTASAHKFDPSEDRIHDLVGVPEVVADKPTEESVEALHQTLAIVSSIGSVCELAAISKFFNGNPVLGTLGGGIESFTGRSGRKRWAEIEAVIGRGWDGVLDAIDEIVTVPEGIDADAVKKAEAELEEPAPEEDEDDISVEAVAEDSDADDTDEAEETERIADDRAVLGGDEDFWLKVGIDPVRIMTGSGTVYTLRCYLDDEPVFLGRNGRISVFSSERALARYLADEHDHDLSDLATYDDIRTAATDGSLRVDVSDENVYVLSGLADDIADGPDAIDRDQLELAVELLRDVSDYSEDKTVDETLSTDEPLGAFVAYVLDPDKADKPAGPYADAVEQWESLERFVESRLRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAS1</accession>
    <name>A0A132PAS1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000055">
        <property type="protein sequence ID" value="KWX19426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043416443.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000055.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19426">
        <property type="protein sequence ID" value="KWX19426"/>
        <property type="gene ID" value="AFM11_35940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6266"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="137" mass="14778" checksum="DCD70C784DB83C23" modified="2016-06-08" version="1">MNAASKPSGLEVGSTRPLSRAERRAQAARVQPEQTPAAPAAEATSPQPDDENPPPRPASAAPTPNQDQESAELAVRLKPRQRKAKNPFATQLHSGTLARLEWIKARGYVITDTVDDAINTYLDGAGIPRPDHNDRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAS7</accession>
    <name>A0A132PAS7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000052">
        <property type="protein sequence ID" value="KWX19436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067860006.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22500"/>
    <dbReference type="EnsemblBacteria" id="KWX19436">
        <property type="protein sequence ID" value="KWX19436"/>
        <property type="gene ID" value="AFM11_35880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6255"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="36730" checksum="317BA147D0EC4E8D" modified="2016-06-08" version="1">MRARVSAADVARAVGVSPATVSYVMNGRSGVSEQTRARILEVAEELGHISSARADRLRSHQTRVIGLVLTDIANPFYTEIAAGTIDAARARGYEVFLAHTQEDPDTLRSVVDAMIARHVDGVVFTVLHPDDGDVIRALRSAHIPLVQLSRRIERIDADFVGIDDRAAASEMMEHVVGHGYRDIVTIVGPRTSSASAAREEGFVHTAESHGIRSIASHRISTYLSERGGYVAVEQVLARKAIPHVIVCGSDAIALGAISALRAHAINVGEDVAVTGFDGLYPGTSPLVELTTVNQPRREMAEQAIELLTRRIDGAGGSFQSVLRAHQLRIGTTCGCPRNRAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB20</accession>
    <name>A0A132PB20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000043">
        <property type="protein sequence ID" value="KWX19531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040748.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19531">
        <property type="protein sequence ID" value="KWX19531"/>
        <property type="gene ID" value="AFM11_35360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5803"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="15"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="248" mass="26247" checksum="323F6192FAD945E6" modified="2016-06-08" version="1">MRGSQPPVVHEEQRQAIAMACRVLAGRGLADGILGHISARTGENELLVRCRGPKERGLAHTEANDIRLVDLDGNPAAEGELDSGYTVPNELPLHTELLRRRPDINSVVHAHPPQVVAADLAGLAIRPIVGAFDIPGTRLAADGIPVYPRGVLVRNRELAAEMLDAMGDRPVVLLRGHGLTSAAPTMEQAVLQAISVNTLAGLSLQITAAGGQLHDLPGPDMAELPDLGGPFNIATAWRHELARLSVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB84</accession>
    <name>A0A132PB84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859597.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02035"/>
    <dbReference type="EnsemblBacteria" id="KWX19601">
        <property type="protein sequence ID" value="KWX19601"/>
        <property type="gene ID" value="AFM11_34985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5726"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="49"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="414" mass="44854" checksum="762BAAB2A2DA2D14" modified="2016-06-08" version="1">MTMNAKRRRRHDKLAALPGVRAVRRPVSPGSDEQFDLYYVRTGRKSARPVVIIPGGPGVASIQQYRGLRRRAATAGLDVIMVEHRGIGMSRHTDSGSDLPPAAITIDQVVDDVAAALDDAGVRTAVVYGTSYGTYIAAGFGVRHRERVAAMVLDSPLLSTDDIEEMRTAIRDLLWNGCDPQTARIAPKVRRLVADGVFKSSGGQLAGLLYGYGGARLLDRQLDLLLHGHTLVWSALRRMGRLSMRKAPYRNEADLVGRIAFRELNYAGVPDGLPLDPALELGEMASSTKFYEPFDTEPYDLIAEMPKFDWPTVVVSGGRDLTTPPAVAERVASLIPDAVLVRLPSAAHSILDTRERAAFAVMRAIYDDGAEQLPATAPELDALPGRTPVRLLVSAISAATALESMLPVRRSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBC8</accession>
    <name>A0A132PBC8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol acyltransferase/mycolyltransferase Ag85A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34825</name>
        <name evidence="3" type="ORF">AWC31_10970</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859493.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10970"/>
    <dbReference type="EnsemblBacteria" id="KWX19633">
        <property type="protein sequence ID" value="KWX19633"/>
        <property type="gene ID" value="AFM11_34825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08999">
        <property type="protein sequence ID" value="ORX08999"/>
        <property type="gene ID" value="AWC31_10970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5314"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX08999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="339" mass="37032" checksum="6F013400542BCC1F" modified="2016-06-08" version="1">MKFIRKLRGTSNESRAWNGLRRFMVGALAALALPGLIGFAGGSASAGAFSRPGLPVEYLDVFSQAMNRNIRVQFQGGGPHAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSTVMPVGGQSSFYTDWYQPSKGNGQDYTYKWETFLTQELPAWLEANRGVSQTGNAVVGISMAGSAALTYSIYHPQKFIYAGTLSGFLNPSEGWWPMLIGLAMNDAGGYNAESMWGPSTDPAWKRNDPMVNMNQLVANNTRLWIYCGTGTPSDLDAGSSGGNLMAAQFLEGLTLRTNITFRDNYIAAGGTNAVFNFPPNGTHAWNYWGAQLQQMKPDIQRVLGAQSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBE2</accession>
    <name>A0A132PBE2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metabolite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_34850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859499.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10990"/>
    <dbReference type="EnsemblBacteria" id="KWX19636">
        <property type="protein sequence ID" value="KWX19636"/>
        <property type="gene ID" value="AFM11_34850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5319"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="453" mass="47010" checksum="C0AC1F922B8F5D2F" modified="2016-06-08" version="1">MSQAGHLIDDAPLTSFHKKLTLFSSGGPFIDGYALSIIGVALITLEPAMSLSATEIGLIGAASLIGIFVGGGVFGYVTDKVGRHLMYIADLIALAVFSVLSAFATEAWQLILLRFLLGVAIGADYPIATSLLAEFLPKKQRGRLLGAMFVVWAVGAAAAYVVGFLLRDYGPDAWRLLLASPAVFAVITLLARMGTPESPRWLLSKGRVAEADAAIKQAFGPQFGVGDLDQNDGETARTTSFAQVFKRPYLNRTIFVAVFWTAQVIPLFAVYTFAPDLLASFGLEGDANLYGGSLLISLLFVVGGIPGLYLVEKIGRRALLIGSFAVIAVALAIPALIPGIPPVAFFLALAVYALASGASSFLEIVYPNELFPTEVRATAVGVGTAVSRIGSAGGTYLMPLALTALGAGGALGVGAAVTAVGLVVAIFMAPETRGVALTESAAPSPAEEQLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBF2</accession>
    <name>A0A132PBF2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cro/Cl family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_065070328.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19659">
        <property type="protein sequence ID" value="KWX19659"/>
        <property type="gene ID" value="AFM11_34550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5255"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="111" mass="12582" checksum="28B52C70331525B0" modified="2016-06-08" version="1">MKRDVDYQWRLAELMAGNQMHNSTDLIPRLNERGITLSRPQVYRLVHQRPERVSLKLIAALCDIFDCGPDDLVTVTAADARKKAASAGRENVVELNKAIRPKRARILSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBT8</accession>
    <name>A0A132PBT8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000049">
        <property type="protein sequence ID" value="KWX19452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19452">
        <property type="protein sequence ID" value="KWX19452"/>
        <property type="gene ID" value="AFM11_35775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5891"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="81" mass="9019" checksum="BA437F42A141D093" modified="2016-06-08" version="1">MVSFVVRWGPFDHGDEYILPEFGMAPAIFYRRVLVLVRDAPPPAMGESDRQRVIVLCLAKLAALSVPDRTRTRSAGHPPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBW2</accession>
    <name>A0A132PBW2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859068.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02540"/>
    <dbReference type="EnsemblBacteria" id="KWX19784">
        <property type="protein sequence ID" value="KWX19784"/>
        <property type="gene ID" value="AFM11_34090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5155"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="30161" checksum="102C477081A5FE04" modified="2016-06-08" version="1">MPTITTSDNVEIFYKDWGSGQPIVFSHGWPLSADDWDTQMLFFLHHGYRVIAHDRRGHGRSEQVADGHDMDHYADDLAAVVEHLDLHDAIHVGHSTGGGELTHYLARHGQDRAAKAVLISSVPPLMVQTDANPGGLPKSVFDDLQAQLAANRSEFYRALPSGPFYGFNRDGVEPSEAIIANWWRQGMMGGAKAHYDGIVAFSQTDFTEDLKKITIPSLVMHGDDDQIVPYANSGPLSAKLLPNSTLKTYPGFPHGMPTTQAETINADLLEFIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC04</accession>
    <name>A0A132PC04_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_33300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858623.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02415"/>
    <dbReference type="EnsemblBacteria" id="KWX19859">
        <property type="protein sequence ID" value="KWX19859"/>
        <property type="gene ID" value="AFM11_33300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4992"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="192" mass="20593" checksum="98E010320C9AC376" modified="2016-06-08" version="1">MAVHLTRIYTRTGDDGTTGLSDFSRVSKNDARLAAYADCDEANAAIGVAIAMGGPNQQMSAVLRQIQNDLFDAGADLSTPVVENPEHPPLRISQPYIDRLEKWCDEFNEGLPALNSFVLPGGTPLSALLHVARTVARRAERSAWAAIDQHGDSVSVLPAKYLNRLSDLLFILSRAANPDGDVLWKPGGGAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC57</accession>
    <name>A0A132PC57_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858848.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08035"/>
    <dbReference type="EnsemblBacteria" id="KWX19817">
        <property type="protein sequence ID" value="KWX19817"/>
        <property type="gene ID" value="AFM11_33720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5080"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="264" mass="28160" checksum="AB5CF75AA63D7CA0" modified="2016-06-08" version="1">MTILVTGATGNIGRRIVDELITLGATDIRALTKNPAKANLPAGVSVLTGFLGDLDSLDGVFDGVERMYLAPYPPTLDATLERIKQAGVGYVVALSGGAHWTEHADAVRASGLPHTQLGPGEFIDNFTIWAEQIKQTGTVREPYPSVVEAPISMDDIARVAARLLVEPAHHGEMLDLTGPEALSRAEIARQIGVGIGRPVAFEQCARDEAEATLRPIMGDAAAWYLDAVSANEEPQRANQLVAELTGTPAMSVAQWAARNAEQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC72</accession>
    <name>A0A132PC72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33110</name>
        <name evidence="2" type="ORF">AWC31_17115</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858499.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17115"/>
    <dbReference type="EnsemblBacteria" id="KWX19935">
        <property type="protein sequence ID" value="KWX19935"/>
        <property type="gene ID" value="AFM11_33110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18111">
        <property type="protein sequence ID" value="ORX18111"/>
        <property type="gene ID" value="AWC31_17115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4954"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="385" mass="40661" checksum="9FA993E217A0B621" modified="2016-06-08" version="1">MLSGKAAIAGIGATDFSKNSGRSELRLAAEAVLDALDDAGLSPSDVDGLVTFTMDSNLETAVARSTGIGDLKFFSQIGYGGGAAAATVQQAALAVATGVAEVVVAYRAFNERSEFRFGQVMTGLTTNADSRGVEYSWSYPHGLSTPAASVAMIAQRYMHEYGATSADFGAVSVADRKHAANNPKAHFYGKPITIEDHQNSRWIAEPLRLLDCCQETDGGVAIVVTTPERAKDLKHRPAIIEAAAQGAGADQFTMYSYYRDELGLPEMGLVGRQLWEQSGLSPADIQTAVLYDHFTPYTLIQLEELGFCGKGEAKDFIADGAIEIGGRLPINTHGGQLGEAYIHGMNGIAEGVRQLRGSSVNQVDNVEHVLVTAGTGVPTSGLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCA1</accession>
    <name>A0A132PCA1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylylsulfate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858602.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16940"/>
    <dbReference type="EnsemblBacteria" id="KWX19965">
        <property type="protein sequence ID" value="KWX19965"/>
        <property type="gene ID" value="AFM11_33290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4990"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="169" mass="18264" checksum="30F588F09E306C22" modified="2016-06-08" version="1">MVSEAVFIGGRSGSGKTSVGFEVHAKLSAAGVAHCLIDGDFLDMAYPAPQEHNLAERNLAAMWQNYRELGYHRMLYTNTASVLPEEIKRLSAAIGGNPKITAILLTCTDATARKRLSQREIGSALERHLTSSKEMSARLQAGADAAHRIATDDRTVAEIAADIIRISGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCL7</accession>
    <name>A0A132PCL7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein mbtH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33040</name>
        <name evidence="3" type="ORF">AWC31_17185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX18177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858605.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17185"/>
    <dbReference type="EnsemblBacteria" id="KWX19967">
        <property type="protein sequence ID" value="KWX19967"/>
        <property type="gene ID" value="AFM11_33040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18177">
        <property type="protein sequence ID" value="ORX18177"/>
        <property type="gene ID" value="AWC31_17185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4939"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="72" mass="8456" checksum="A8D72CE3E09C4D36" modified="2016-06-08" version="1">MSINPFDDDNGTFYVLINDEEQHSLWPTFSDVPAGWRVVFGEADRAACLDYIEKNWPDIRPKSLRDRLARER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCT5</accession>
    <name>A0A132PCT5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_31840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857755.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20140">
        <property type="protein sequence ID" value="KWX20140"/>
        <property type="gene ID" value="AFM11_31840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4694"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="284"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="450" mass="47352" checksum="418007A73CA936CC" modified="2016-06-08" version="1">MTEVETELSRFVAETNWDALPEAIRHRVTDIWADTVANALAGRRAANTPAVERLAARLTGPGDSVIIGGGSSSMTGAALINGFQITAFTMCDVYRPALCHITPEVVPVVLALADDGRNLLVGLAVGLELTARLGLGLDYPTFRGRGWHAPGVIGTIGAAAAGARVLGLDHRQIRAAMGLGASQASGTFAALGTAAVKFHQARGAVSGLWAALFAADGLGGSQRGLTHPDGGVLTTYTDGGRPDLILDGLGERWELEQISLRRWPAASSLQSLVAGLLDFTDVGTESVRSAQLELPPSSYAMCAEMGWEDELSAMQSARYVTAAVLADRRCWTEQFSAERRVDPAINRFASGVSVRQGTDLPPSGVRIRLTRTDGTVVETTRDTAPGEPSDPLTRPQIIDKLQAAAVTTPVSGGDLVRVVYATDGCDGASVRAALCAPTAERSEREYAQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD29</accession>
    <name>A0A132PD29_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_31315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857441.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25470"/>
    <dbReference type="EnsemblBacteria" id="KWX20230">
        <property type="protein sequence ID" value="KWX20230"/>
        <property type="gene ID" value="AFM11_31315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4169"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="220" mass="23989" checksum="502BADB354DFD29B" modified="2016-06-08" version="1">MSGKRKAGPNTVDAELILDTAAVLIERDGVAGFSMRGLAERLGVAVTSIYWHVGGRDKLFDSLVDRLLGEMANLPMDGTGPLERIASLARTQRRLLIERQHLLALAHERDRTPTLFLPVQQRLAAQLAELGISGTDAALALRAVEVHVISSAVMQFSAVRGPAHQEEDPSLWTAEWPDQELVEALQSPTDYDAVFEYGLDALLVSLRGRRIVKAGRSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD67</accession>
    <name>A0A132PD67_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857704.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26270"/>
    <dbReference type="EnsemblBacteria" id="KWX20288">
        <property type="protein sequence ID" value="KWX20288"/>
        <property type="gene ID" value="AFM11_31655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4235"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="230" mass="25175" checksum="1F2769ACD7A1522F" modified="2016-06-08" version="1">MVADDGTLLHVGVTGAGPDVVVLSGGPGCVHYLEDDALAPRGMRAWFPEPRGVALSAGGPHDLAQAVADLESVRRSQRIDRWVVVGHSWGSDLAVRYALDHPDRVASVVGVAGHGLHKDRTWSQAYEAARHLEADLQIPWEPAIHAALTASFVQWIHEPDLLRRLADSDVPMTFLAAEHDIRPSWPLRQLAALVRHGRFEEIPDVGHNLWSTDPDVWVDYVTKACLGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDE3</accession>
    <name>A0A132PDE3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_30880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857166.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26600"/>
    <dbReference type="EnsemblBacteria" id="KWX20358">
        <property type="protein sequence ID" value="KWX20358"/>
        <property type="gene ID" value="AFM11_30880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4078"/>
    <dbReference type="UniPathway" id="UPA00670"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="177"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="322" mass="36108" checksum="DE0533CB9FD8619B" modified="2016-06-08" version="1">MTSDMTELQRERGMGGLGTERAREVRRISLAGLDTRRADIADELWSAATDIGFFQVVDHGIDLDDVGRAFAMAEAFFALPDDVKARRPKRFNSGWESLTQIRPSVGTPDQKESYQVSLSDMDGLWPTAEELAGFRETMLDFEHKCWALAMELLSLFADKLGFDRDFFTRAHDPSSATYQSTLRLLHYFAVPADADLDGMWRAGAHTDFDCLTLLFQRAGQGGLQVCPGKESAEQEWTPIEPSDDVITCNIGDMLMRWSDDALPSNFHRVRSPGPDEHRGARYSIAFFAQANSEVTIAGPHRKYPPISAKDYLQQRITANFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDK6</accession>
    <name>A0A132PDK6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_30775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857375.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26495"/>
    <dbReference type="EnsemblBacteria" id="KWX20421">
        <property type="protein sequence ID" value="KWX20421"/>
        <property type="gene ID" value="AFM11_30775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4056"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="209"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="613"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="696" mass="75132" checksum="9F5421EA4DE1215A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDR8</accession>
    <name>A0A132PDR8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856874.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20475">
        <property type="protein sequence ID" value="KWX20475"/>
        <property type="gene ID" value="AFM11_30340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3966"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="123" mass="12664" checksum="986408B41EC19C62" modified="2016-06-08" version="1">MSKSPVQVDDETCCPPGALLGEPLTAAEAIDMAVKLKALADPVRLQLFSAIASHAGGEACVCDISVGVEVSQPTVSHHLKVLRDAGLLTSERRASWVYYAVVPDALASLAVLLGAEITAGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDS6</accession>
    <name>A0A132PDS6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856913.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20485">
        <property type="protein sequence ID" value="KWX20485"/>
        <property type="gene ID" value="AFM11_30410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3982"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="248" mass="26336" checksum="68B1B1619DD00A18" modified="2016-06-08" version="1">MGKGARTRGPKRGSPVTRMTTGRPWGSVAAVAAVVVFAGAVFGYIYVRSGDQRERQAALAPFAPSAANQDPSLQIPGIVVKSYRGADHVAPTQRVAYDGNPPYGGPHDAAWAACDGVVYSVPIRAENAVHSLEHGAVWIAYHPDKIVGTDLEGLRGRARGNNYVFMSPVPTMNSPVSLQSWGHQLTLDDANDERIDQFISALRTNRFTHPEVGATCAPLGPGRFDPANPPPFDPTPHGPDAVPVDGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEF6</accession>
    <name>A0A132PEF6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856603.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25225"/>
    <dbReference type="EnsemblBacteria" id="KWX20607">
        <property type="protein sequence ID" value="KWX20607"/>
        <property type="gene ID" value="AFM11_29885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3869"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="255" mass="27003" checksum="38EFFD3E7F0DA157" modified="2016-06-08" version="1">MTILLTADHGAVRVVTMNRPEARNALGAELIEALYTALDAADADEAVRAVVLTGTDPAFCAGVDLKQAQSLGLEYFERFQTHNCITKTGQMRTPIIGAINGATFTGGLEMALGCDFLIASEHAVFADTHARVGILPGGGMTARLPHVVGAAMARRLSMTGEVVDAMRAERLGLVTEVIPHSQLMERALELAGQIAEVPGPIMAGLKEIYVRGTDPVISPALAAEREIAGAQKRDFDALGDQYRAVAQRNKNQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF94</accession>
    <name>A0A132PF94_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF222 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21008">
        <property type="protein sequence ID" value="KWX21008"/>
        <property type="gene ID" value="AFM11_26825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3236"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF222" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="26676" checksum="7342AA9FD5170658" modified="2016-06-08" version="1" fragment="single">LNAEARAVVEPLLAKYAAPGMCNPDDPAPCVTGVPSEEAVEADTRTAAQRNHDALVAIGRHALMSGELGSHSGLPVSLIVTTTLAELEAGAGIAVTAGGSKLPIPDLIRLAAHAWHYLAVFDDATLVPLYFGRTKRIATPAQRLVLFARDRGCTRPGCTAGGYRCQAHHAQHDWTVGGQTNIDELALSCGPDNRLVTKGKWTTTMRNGRCQRTPPPLLDTGQARTNGYHHPQTYLTDNNAEDDETNCQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFM2</accession>
    <name>A0A132PFM2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27370</name>
        <name evidence="2" type="ORF">AWC31_07305</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855583.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07305"/>
    <dbReference type="EnsemblBacteria" id="KWX21146">
        <property type="protein sequence ID" value="KWX21146"/>
        <property type="gene ID" value="AFM11_27370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10332">
        <property type="protein sequence ID" value="ORX10332"/>
        <property type="gene ID" value="AWC31_07305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3348"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="145" mass="16173" checksum="59B57830CEDE8539" modified="2016-06-08" version="1">MADKTAQTIYIDADPSTVMDVIADIGSYPDWVAEYKETEVLETDDEGYPKTARLVLDAAVLKDTMVLAYDWPADRTSVTWSLVSSSLLRSLQGAYRLKPKGSGTDVTYELSVDLIIPMIGLLKRKAERRLTDTALKDLKKRVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFM4</accession>
    <name>A0A132PFM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855589.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07370"/>
    <dbReference type="EnsemblBacteria" id="KWX21148">
        <property type="protein sequence ID" value="KWX21148"/>
        <property type="gene ID" value="AFM11_27435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3361"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="198" mass="21895" checksum="47AF4BF4E40E23E6" modified="2016-06-08" version="1">MAAYLIDLSPDDMQRRLPDALRVYVDAMRYPRGTEEQRAALWLEHTRRSGWKAVAAIDIAGPNSAPTSTDLATAPLLGVAYGYCGAPDQWWQQQVVAGLRRVGASPARISELMTSYFELTELHIDPRAQGHGLGEALARRLLAGRGESHVLLSTPEINGEANRAWKLYRRLGFTDVIRGYHFAGDPRAFAILGRSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFZ0</accession>
    <name>A0A132PFZ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_27830</name>
        <name evidence="5" type="ORF">AWC31_10360</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX08900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855979.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10360"/>
    <dbReference type="EnsemblBacteria" id="KWX20902">
        <property type="protein sequence ID" value="KWX20902"/>
        <property type="gene ID" value="AFM11_27830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX08900">
        <property type="protein sequence ID" value="ORX08900"/>
        <property type="gene ID" value="AWC31_10360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3440"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="13"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX08900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="337" mass="34365" checksum="293A1B61AF062234" modified="2016-06-08" version="1">MSTHRAVHVQSTGGALELADAQTVPPERGQVRVAVAACGVCGTDRAIVNGGFPGVSFPLTPGHEIAGTVAETGPGVDEFAVGDRVAIGWFGGACGKCIPCRKGLFIHCENGQIPSLHYPGGYAESVTAPANALARIPDELSFAEAAPMGCAGVTTYNALRHTHALPGDLVAVLGVGGLGHLGVQFANAMGFDTVAIARGPDKEADARALGARHYIDSRAEDVSAQLQKLGGAAVVLATAGNSQAMADTVGGLAPRGELVAVGVATDPLAISPAQLIQPALSISGHPSGTARDVEETMRFAVVSGVRAMIEERPLADAADAYAAMEEGRARYRMVLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG24</accession>
    <name>A0A132PG24_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NrdH-redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25565</name>
        <name evidence="3" type="ORF">AWC31_24715</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854415.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24715"/>
    <dbReference type="EnsemblBacteria" id="KWX21298">
        <property type="protein sequence ID" value="KWX21298"/>
        <property type="gene ID" value="AFM11_25565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14416">
        <property type="protein sequence ID" value="ORX14416"/>
        <property type="gene ID" value="AWC31_24715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2976"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011915">
        <property type="entry name" value="GlrX_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02200">
        <property type="entry name" value="GlrX_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX14416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="82" mass="8614" checksum="F49EDF719166CBEA" modified="2016-06-08" version="1">MTASSTALTMYTTTWCGYCSRLKTALKAEGIPYTEIDIEADPSAAEFVGSVNGGNHVVPTVKFADGSTLTNPSIKQVKAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGB1</accession>
    <name>A0A132PGB1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854692.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35760"/>
    <dbReference type="EnsemblBacteria" id="KWX21389">
        <property type="protein sequence ID" value="KWX21389"/>
        <property type="gene ID" value="AFM11_26135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3092"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="33119" checksum="A07494E7334AC0D8" modified="2016-06-08" version="1">MTEEGLRPLVVVTVTYSPGPHLDRFLASLSLATERPVTVIMADNGSTDGAPEEAEQRYPNVRLLRTGANLGYGSAVNRAAAEISPDTDCAEFFVVANPDVQWGPHSIDLLLEAADRWPHAGAFGPLIRDPDGSVYPSARHQPSLVRGGMHAVVGPFWKSNPWTAAYRQEREEPSERPVGWLSGSCLLLRRAAFDAIDGFDERYFMYMEDVDLGDRLGRAGWANIYVPSAEVLHYKGHSTGRDPARNLAAHHRSTYTFLADRYPAVWQAPLRWTIRGALAVRAGLVVGKSRRMQSKRGALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGG2</accession>
    <name>A0A132PGG2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_27295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855395.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07230"/>
    <dbReference type="EnsemblBacteria" id="KWX21082">
        <property type="protein sequence ID" value="KWX21082"/>
        <property type="gene ID" value="AFM11_27295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3334"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="295" mass="30636" checksum="8E45E868D55E7B70" modified="2016-06-08" version="1">MSGPNPPGPDGSGSDLPDQQPGKHSAPEEPTQVAGTDPNTGETEFYSQAYSAPESEQFTSGPYVPAEPGLYDYDSYDPVTELVDQPPPPRWPWVVGVTAIIAAIALVASVAVLVTRDDDTTNLATPQPSTTTSAPPFQDEITTTTPPPPPPPPPPTSEEPPPPPPETVTVTEPPPPPPPPPSSEAPPPPPATTTTPPPTTTTAPAGPRQVTYSVTGTKAPGDIITITYVDGNGNRRTLRNVYIPWTFTMTPISNSDVGSVEASSLFLVSRLNCSITASDGTVLSSNANNSAQTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGL9</accession>
    <name>A0A132PGL9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,5-diketo-D-gluconic acid reductase</fullName>
            <ecNumber evidence="5">1.1.1.274</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dkgA</name>
        <name evidence="5" type="ORF">AFM11_25065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.274" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854137.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27385"/>
    <dbReference type="EnsemblBacteria" id="KWX21485">
        <property type="protein sequence ID" value="KWX21485"/>
        <property type="gene ID" value="AFM11_25065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2374"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050580">
        <property type="term" value="F:2,5-didehydrogluconate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="30"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="283" mass="29994" checksum="4E3734139B6F2CD3" modified="2016-06-08" version="1">MTSSHGQAAAIPTVTLNDDNTMPVVGLGVGELSDAEAERSVSVALEAGYRLIDTAAAYGNEAGVGRAIAASGLPRDEIFVTTKLATSDQGFQSSQDAARASLERLGLDYVDLYLIHWPGGDTSKYVDSWGGLMKAKEDGVARSIGVSNFSADDLSTIVHLTFFTPAVNQIELHPLLNQAELRAANAEHNIATEAYGPLGVGRLLDNPAVTAVAEAHGKTPAQVLIRWSVQLGNIVIPRSANPDRIASNLNVFDFELTEDEMASLNGLDEGTRFRPDPATYTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGS0</accession>
    <name>A0A132PGS0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_24930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854329.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27185"/>
    <dbReference type="EnsemblBacteria" id="KWX21464">
        <property type="protein sequence ID" value="KWX21464"/>
        <property type="gene ID" value="AFM11_24930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2347"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX21464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="397" mass="40930" checksum="A078EE23A068468A" modified="2016-06-08" version="1">MSVSSISTIRRWSMLGIALTATTCANVFINGAAFLIPTLHTERGLDLAKAGLLSAMPSFGLVITLIAWGYLVDRVGERIVLTVGSALTAAAAFAAASAESLVAVGVFLLLGGMAAASSNSASGRVVVGWFPPEQRGLAMGIRQTATPLGVGLGALVIPRVAESHGASTALLFPAVVCVLSAVVCAIGVLDPPRPPRHEAPREHLANPYRGSSVLWRIHAVSVLLVIPQGMVWTFTLVWLMSDRGWSASSAGALVTVAQLLGAAGRIAAGRWSDVVGQRLRPIRTIALGAAATMALLAFTDWLDSPISIALIVIASVITVSDNGLAFTAIAEIAGPFWSGRALGTQNTTQHLATASSSPLFGALIGVAGYPAAFAVCALLPLLAVPLVPPDEGLRDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH20</accession>
    <name>A0A132PH20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_24380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21658">
        <property type="protein sequence ID" value="KWX21658"/>
        <property type="gene ID" value="AFM11_24380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2236"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="219"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="381" mass="39506" checksum="AD7487F1A0F6AF35" modified="2016-06-08" version="1">MVEFAFTDEQVQLRAAVRRFCGENFDEQTVRTLMESEPRFDPKVWARLGTELGVLGLAVPEADGGAGGTLVDQAIAVEELGAVLACGPVFGTVFLAIPALVAASASPVRDKLLGALAEGTRTAAFAVPDRAGAFDAALVTVTAGDGTLTGTVERVVDGDAADVVLVAATGPDGVALYAVDASDVQRTPLVTLDLTRPQANLEFTHAPAQLLAGPDEAERVITQALQVASALLAAEQVGAAQHLLDLSVAYAKSRLQFGRPIGSFQAVKHRLADCLVDLEHARSTAYHAVWALTDGTDDPALAASIAQATASAALAKVAADTIQVHGGIGFTWEHQAHLYLKRATTDAALLGSAEAHRSRVAELVLDGAEADRVPHIATGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH70</accession>
    <name>A0A132PH70_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_24640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853841.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23480"/>
    <dbReference type="EnsemblBacteria" id="KWX21699">
        <property type="protein sequence ID" value="KWX21699"/>
        <property type="gene ID" value="AFM11_24640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2289"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453074" description="Cytochrome bc1 complex Rieske iron-sulfur subunit" evidence="11">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="36"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX21699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="139" mass="13569" checksum="2E52C9388226017B" modified="2016-06-08" version="1">MFLSRRHALVGAGITLAAGTVAGCATYGKPPAETSPPAAAPAPAAPGASVIAKTADVPVGSGVIVGDVVITQPTAGDFQGFSSVCTHAGCTVSEVVGASINCPCHGSSFNLDGTVAKGPAKRPLESKQVAVQGDSITLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH71</accession>
    <name>A0A132PH71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853773.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23620"/>
    <dbReference type="EnsemblBacteria" id="KWX21676">
        <property type="protein sequence ID" value="KWX21676"/>
        <property type="gene ID" value="AFM11_24500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2261"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="1">
        <location>
            <begin position="263"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="515" mass="54273" checksum="6B25F23B9BCA3F73" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PH79</accession>
    <name>A0A132PH79_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853764.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23640"/>
    <dbReference type="EnsemblBacteria" id="KWX21673">
        <property type="protein sequence ID" value="KWX21673"/>
        <property type="gene ID" value="AFM11_24480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2257"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="149" mass="16601" checksum="40E98C821E72612F" modified="2016-06-08" version="1">MGRKNVETLQCSVARSLAVLGERWTILILREALLGTTRFADFQTRLGIGADMLSDRLATLVDYGVMTKTSYQEPGQRARPEYRLTPAGRELHVLVGALQQWGDRHLPRPEGPTVELKARRTDRPVHVAFIDDLGYEVPSDDVAAMLTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHZ0</accession>
    <name>A0A132PHZ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_23155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853389.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27920"/>
    <dbReference type="EnsemblBacteria" id="KWX21874">
        <property type="protein sequence ID" value="KWX21874"/>
        <property type="gene ID" value="AFM11_23155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1983"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="449"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="503" mass="53804" checksum="5CADAA51310AEC62" modified="2016-06-08" version="1">MTSLWLADRAERPLPPEPLDEINRSADVVVVGAGITGLITAVLLARAGKDVLVLEAHTAGAGTTGNTTAKISLLQGTKMSSILKKHGPKIAKQYVEGNLEGQQWLVGHCEAHGLSVQREAAYTYAQSEDGVRLARNELEACRTAGLDVEWIDGNDAEVPFPFHGGVRLADQAQFNPMPLLDSLIVELDERGGRLAQGVRVQRVSDDGGGLKLHVRTNAGAEFDVLASRCVLATGIPILDRGGFFARLSPNRSYCMAFRVPGNLTRGMYISADSPTRSVRYAPTPDGDRLIVGGAGHLVGRRANAAQSVQELASWAKVHWPGAMQTHYWSAQDYSPVDELPYVGPILPGHEKIFVATGFDKWGMTNGTAAALALSSQILGGRMDWATAFASWSPHELSGIPAAMKVNLEVGLNLAKGWITPVTRIGSHVPDDGGVVSGPPWHMEACSVIDGVEHRVSPVCPHLGGIVNWNDADESWECPLHGSRFAPDGTLLEGPATRNLTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI11</accession>
    <name>A0A132PI11_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_22530</name>
        <name evidence="4" type="ORF">AWC31_08680</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852755.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08680"/>
    <dbReference type="EnsemblBacteria" id="KWX21943">
        <property type="protein sequence ID" value="KWX21943"/>
        <property type="gene ID" value="AFM11_22530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10228">
        <property type="protein sequence ID" value="ORX10228"/>
        <property type="gene ID" value="AWC31_08680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1857"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX10228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="284" mass="31162" checksum="C0C01FA2ED1DFFA8" modified="2016-06-08" version="1">MPLPQLADILATLDLAGSGDNTFVATQLDNANHHIVGGHIAAQALMAASRTAPGRLPHSVHVYLLRAGDARYPVDMEVVNLRDGGALSTRQVRAQQGGEVLLEALVSLTAPVEAMDYHQPLPDVPAPEALAPVEDQLSAYADEHHGFWVRPQWIARRYVDAPPRLAMDMPDPPQHTRMWWRPTEPVTDDPLVNCCLLTYVTGTTMLETSVTMRRTTQIDSFSALIDHAVWFHRPADLSDWVLSDQVSPSGIGGRGLATGTMYNRAGQLVCTATQEIYFGRDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI85</accession>
    <name>A0A132PI85_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsf</name>
        <name evidence="10" type="ORF">AFM11_21310</name>
        <name evidence="11" type="ORF">AWC31_04125</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852284.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04125"/>
    <dbReference type="EnsemblBacteria" id="KWX22056">
        <property type="protein sequence ID" value="KWX22056"/>
        <property type="gene ID" value="AFM11_21310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10496">
        <property type="protein sequence ID" value="ORX10496"/>
        <property type="gene ID" value="AWC31_04125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1609"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="9">
        <location>
            <begin position="67"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX10496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="271" mass="28911" checksum="CF445F3352DF4E8F" modified="2016-06-08" version="1">MANYTAADVKRLRELTGAGMLDSKNALVEADGDFDKAVELLRIKGAKDVGKRAERATAEGLVAAKDGALIELNSETDFVAKNAEFQALADQVVAAAAASKAADVDALKAAKAGDTTVEQAIADLSAKIGEKLELRRVAYFDGQVETYLHKRAADLPPAVGVLVEYTGDSQEAAHAVALQIAALKAKYLTREDVPEDIVANERRIAEETAKEEGKPEQALPKIVEGRVTGFYKDVVLLDQPSVSDSKKTVKALLDEAGVTVTRFVRFEVGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIP6</accession>
    <name>A0A132PIP6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="5">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">truB</name>
        <name evidence="9" type="ORF">AFM11_22070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04875"/>
    <dbReference type="EnsemblBacteria" id="KWX22181">
        <property type="protein sequence ID" value="KWX22181"/>
        <property type="gene ID" value="AFM11_22070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1762"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015225">
        <property type="entry name" value="tRNA_psdUridine_synth_fam2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09142">
        <property type="entry name" value="TruB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="6">
        <location>
            <begin position="42"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="8">
        <location>
            <begin position="195"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C" evidence="7">
        <location>
            <begin position="251"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="311" mass="32793" checksum="3833BCFF8C87D70E" modified="2016-06-08" version="1">MVGARRRDADGDRAVKVAPEPGLVIVDKPAGMTSHDVVGRCRRLFGTRKVGHAGTLDPMATGVLVIGIERATKILGLLTATDKSYAATIRFGRTTTTEDAEGEVVEDVSAAAVTDAQIESAVAALRGDIAQVPSAVSAIKVGGQRAYKLAREGQAVELAARPVRIDRFEVLAVRREGEFVDVDVEVDCSSGTYIRALARDAGAALGVGGHLTALRRTKVGRYGLDEARTLDGLAEQARLSYSLDEACLLGFPRRDLTADEAEDTRHGRALKPAGIDGVYAATAPDGQVIALLQDGSARTKNVVVLRPATLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIV4</accession>
    <name>A0A132PIV4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="7" type="ORF">AFM11_22140</name>
        <name evidence="8" type="ORF">AWC31_04900</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_036437013.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04900"/>
    <dbReference type="EnsemblBacteria" id="KWX22194">
        <property type="protein sequence ID" value="KWX22194"/>
        <property type="gene ID" value="AFM11_22140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10626">
        <property type="protein sequence ID" value="ORX10626"/>
        <property type="gene ID" value="AWC31_04900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1776"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX10626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="89" mass="10334" checksum="04905B6015819071" modified="2016-06-08" version="1">MALTAEQKKEILGSYGLHETDTGSPEAQVALLTKRISDLTEHLKVHKHDHHSRRGLLLLVGRRRRLLKYVAQVDVERYRSLIERLGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIV8</accession>
    <name>A0A132PIV8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_20870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06285"/>
    <dbReference type="EnsemblBacteria" id="KWX22289">
        <property type="protein sequence ID" value="KWX22289"/>
        <property type="gene ID" value="AFM11_20870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1513"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="273" mass="28652" checksum="412226BAEE3B67D3" modified="2016-06-08" version="1">MFAPACSAGPLGDSTRPQAPQSEAGYAPAPAAPPPTGGGPGLKEAPQPADSNRDVVKTASMTITAADTTDSADKAVSITTDAGGRVDSRSEDAGTSSGRARIALVLRVPVAKLDATLDEFKKLGTVDTVEIRAEDVTSQRVDLDARITALQTSVDRLLGIMRDARDPDALIKAEEALSQRQADLDSLRAQRKQLGDQIDYSTVNLELIAEQVGGPTEQYHGFFGQVERGWDGLVAVASGAVMLFGLMLPWLVALVVVGAIGYAVIRLVTSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJA5</accession>
    <name>A0A132PJA5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inosine-5-monophosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.205</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_19945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851871.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28570"/>
    <dbReference type="EnsemblBacteria" id="KWX22429">
        <property type="protein sequence ID" value="KWX22429"/>
        <property type="gene ID" value="AFM11_19945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1323"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005991">
        <property type="entry name" value="IMP_DH-rel1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01303">
        <property type="entry name" value="IMP_DH_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="95"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="478" mass="49600" checksum="0D6CC2C9A2F8C2EF" modified="2016-06-08" version="1">MRFLDGHTPPYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVEFVKSRDLVVDTPVTLGPDDSVSDATALLHKRAHGAAVVVFEGRPIGLVTEASCVGVDRFARVRDVALSDFVTAPVGTDPREVFDLLEHAPIDVAVMTEPDGTLAGVLTRTAAIRTGIYAPAVDAAGRLRIAAAVGINGDVAAKARALAEAGVDLLVIDTAHGHQLKMLDAIKAVASLDLGLPVAAGNVVSAEGTRDLISAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGAHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLHDRDDRPYKESYGMASKRAVAARTAGDSAFDRARKALFEEGISSSRMGLDPTRGGVEDLLDHITSGVRSTCTYVGASNLAELHEKVVLGVQSAAGFAEGHPLPSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-02-10" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJK4</accession>
    <name>A0A132PJK4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851959.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22515">
        <property type="protein sequence ID" value="KWX22515"/>
        <property type="gene ID" value="AFM11_20435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1421"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016796">
        <property type="entry name" value="UCP021774"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021774">
        <property type="entry name" value="UCP021774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="129" mass="13926" checksum="D52246300EE08BAE" modified="2016-06-08" version="1">MSYALSTRLHTTFDDAVFRTREALVAQGFGVLTEIDMKATLKTKLGEDMEDYLILGACNPPLAHRAVIADRQIGLLLPCNVVVRADGDSVIVDAMDPQVMVQVSDKPGLREVADEAAAKLRAAIDSLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJR1</accession>
    <name>A0A132PJR1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phenyloxazoline synthase MbtB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mycobactin synthetase protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_20655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family. MbtB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852032.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06070"/>
    <dbReference type="EnsemblBacteria" id="KWX22252">
        <property type="protein sequence ID" value="KWX22252"/>
        <property type="gene ID" value="AFM11_20655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1468"/>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="949"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1463" mass="158147" checksum="88AC42E36A82C21B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJV6</accession>
    <name>A0A132PJV6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851473.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22460"/>
    <dbReference type="EnsemblBacteria" id="KWX22544">
        <property type="protein sequence ID" value="KWX22544"/>
        <property type="gene ID" value="AFM11_18635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1064"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="470" mass="50269" checksum="5FCCBBC4DB4440F2" modified="2016-06-08" version="1">MNSRANSGSRDLHLELRTVIEPGSRTAREQLIQALRDGIRSGRLATGTVLPPSRTLAVDLGLARNTVAEAYAELVAEGWLASRQGAGTWVARSAVTPPARRPRRTTIVPKHNLMPGSPDVAEFPRTAWLASTRRALLNAPVSALRMGDPRGHAELREALAEYLGRVRGVRTTPDSIVICAGVRDGVELLGKVFGTTRPIAVEAYGLFIFRDAWAAMGIKTTPIRIDEQGAVVGDLDGLDTPAALLTPAHQSPFGMALHPARRTAAVEWARRTGGYVIDDDYDGEFRYDRQPIGALQALDPERVIYLGSASKAMAQTLRVGWMVLPEALIDPVIAAAGGQQYHVNAITSLTLADFIGTGGYDRHVRRMRNRYRRRRDALVAALDGFDVDIGGLAAGVNMLLTLPDGAEPEVLHRAGEAGIALNGLAIMRHPMADPALPNPDGVLVGIGGPAEHAFGPAVDALVGVVAEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJX7</accession>
    <name>A0A132PJX7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative phenylalanine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pat</name>
        <name evidence="5" type="ORF">AFM11_18770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the transamination reaction in phenylalanine biosynthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851519.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22305"/>
    <dbReference type="EnsemblBacteria" id="KWX22564">
        <property type="protein sequence ID" value="KWX22564"/>
        <property type="gene ID" value="AFM11_18770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1091"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01513">
        <property type="entry name" value="Phe_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024892">
        <property type="entry name" value="Pat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="25"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="348" mass="37851" checksum="18204B417041EF88" modified="2016-06-08" version="1">MSIRLRPEMADLPAYTPGKTVPGAIKIASNETVHGPLPSVRDAIVKATENINRYPDNGYQDLREHLAKHVNFAPENISVGCGSVSLCQQLIQITSTVGDEVLFAWRSFEIYPLQVRTAGATGVQVALRDHTHDLDAMLAAITDRTRLIFVCNPNNPTSTVVNPDELARFVAAVPPHILIVLDEAYVEYIRDGMAPDSFGLVRAHPNVVVLRTFSKAYGLAGLRVGYAVADPDIVTALGKVYVPFSATSISQAAAIACLDAADELLTRTDAVVAERTRVSTALREAGYELPPSQANFVWLPLAERTLDFVARAADSRIVVRPYGEDGVRVTIGAPHENDALLEFAQRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK36</accession>
    <name>A0A132PK36_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851793.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22710">
        <property type="protein sequence ID" value="KWX22710"/>
        <property type="gene ID" value="AFM11_18660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1069"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="314"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="426" mass="46144" checksum="F2476C97044A1AC0" modified="2016-06-08" version="1">MFENLFDIDPGASEHELRALVEKYELLKPALAAAQARATALWDAKRRAREAADGVPAAKRGKGLAAEVALARREAPKKGDQYLGLAKALVHEMPHTLAALEAGMLSEWRATLIVRESACLDVEDRRRLDVELCADTTRLQGWGNSRVKAEARKIAARLDAAAVVERAAKAAADRRVWIRPAPDTMAYVTVLLPVARAVAVYAACKNAADTTYDDRSRGQIMADTVYERVTGRPADVAEPVAVKLVITDETLFGGSPVPAHISGYGPVPAEVARKLVADAVGDERSKTTLQRLYRHPSSGALVAMESRARLFPKGLAEFIALRDDTCRTPYCDAPIRHTDHAEPSARGGATSAANGEGLCERCNYTKESVGWQVHTFDENGVHTAFFVTPTGAVYRSTAPPLPGAREEFECPTELMLAIEFARPHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK72</accession>
    <name>A0A132PK72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_18940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15030"/>
    <dbReference type="EnsemblBacteria" id="KWX22587">
        <property type="protein sequence ID" value="KWX22587"/>
        <property type="gene ID" value="AFM11_18940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1122"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="156" mass="17584" checksum="4C83353699707ADD" modified="2016-06-08" version="1">MTSQGPELNRATPLNEAALLQYNNRMLDALFRQSPAGPIPDGDTRGTLLAWPGTWLTKPLALLVRIIVWQGKVLDRREAVLRNKVTPFGLRLVKARLSVADSWVDGGDCVLIDYSKTSWLARMVRDEIRLVSPGLYLGVVWLWRKRVGWFAIRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKF5</accession>
    <name>A0A132PKF5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_18010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851227.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12080"/>
    <dbReference type="EnsemblBacteria" id="KWX22829">
        <property type="protein sequence ID" value="KWX22829"/>
        <property type="gene ID" value="AFM11_18010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.958"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="29785" checksum="E3417D7012A23F64" modified="2016-06-08" version="1">MTENSADSARLRDVAEQLATEAAEFVRRRRGEVFGAASGAPESSEAGDGAGPIRSKSTPTDPVTIVDTETERWLRERLAVLRPGEHVLGEEEGGEEDGRDGLSWVIDPIDGTVNFVYGIPAYSVSIAVQRDGRSVAGAVANVAAGEVFSAALGHGAQVRRGDVSTPLRCSAADDLSMTLVGTGFSYVADKRRRQAQVLAEILPVVRDVRRFGSCALDLCMVAAGQLDAYYEEGVNVWDWAAGALIAAEAGATVWLPTGSGPGRLGACAPGVADALRAALAGAGMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKR6</accession>
    <name>A0A132PKR6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22939">
        <property type="protein sequence ID" value="KWX22939"/>
        <property type="gene ID" value="AFM11_18485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1031"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453358" description="NMT1 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="359" mass="39005" checksum="16ED0CED7D42DB27" modified="2016-06-08" version="1">MVKKTVRQALVMLVGVILVVGSAACSGSNDVAGPPGDVSDPNNPVYFKYADNPSFDLVYLADRLGYFENAGIKPKYVGAVDANQLIPLTDTGDLDFSTRMASLTISAINGGADLKIIAASNRTLPDAPHMNYFVRKDSGITPDSLDKLEGKTIAMNGFGACAEYVTKQYLTSKGVNVDAIKWVPTPDAQSEQAVETGGADLAIIHAPFSGHALNNPRLVSLFSDFDLDGGASGSQPYTGNGDFIRRYPAQTEEFVKILGKTQSWVNRNPDQARQFIADRVGQDVKDITRYAYVNNAIIDRQQIQYWIDTLEKFGQLPEGKLTADDVATNKYNPYSDSDELIDTQADNQVDLTELAKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKV2</accession>
    <name>A0A132PKV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_16455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850631.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19865"/>
    <dbReference type="EnsemblBacteria" id="KWX22971">
        <property type="protein sequence ID" value="KWX22971"/>
        <property type="gene ID" value="AFM11_16455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.640"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="211"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="752" mass="79520" checksum="8089FB33EDDC8820" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKZ7</accession>
    <name>A0A132PKZ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850744.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01330"/>
    <dbReference type="EnsemblBacteria" id="KWX23020">
        <property type="protein sequence ID" value="KWX23020"/>
        <property type="gene ID" value="AFM11_16760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.705"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="3">
        <location>
            <begin position="16"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="136"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="4">
        <location>
            <begin position="239"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="407" mass="43833" checksum="833168B02542B36C" modified="2016-06-08" version="1">MVATHTSTKTRTPEAFLDELSGAVDEIRAGAHDRDRNRRYAIDEIERLRGIGFWALTTPVEFGGLGFDQEVLTQAIIAVASADGSLGQIPQNHFSTVERLRLSPSPQRTRFLTAISSGAFFGNAAAEPGERPPGASETTVLQRNGTWTLSGRKVYSTGALLADLITVIARGDDGRPHTVVIPRTTPGVEIHDDWDSFGQRTTGSGTVEFHDVTVEATQILAPLPGTRAQYRHSGLNHVVHAAIDVGLAEGALQEALALARKVHAGRGAEHREFRDDTIGVAALGELRITAWTARRAVESAARQLTKLTDNSGLSAVLEAFYEVAQAKVVAARAALAVTSALFDIGGASSTKPALGLDRYWRDARTHTLHDAVRWKPYAVGKWLIDESVADPWTLAHPLRPLAALADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL20</accession>
    <name>A0A132PL20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_16610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850683.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01180"/>
    <dbReference type="EnsemblBacteria" id="KWX22993">
        <property type="protein sequence ID" value="KWX22993"/>
        <property type="gene ID" value="AFM11_16610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.671"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="576" mass="58625" checksum="CA130313756560FA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL80</accession>
    <name>A0A132PL80_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_17205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850901.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01770"/>
    <dbReference type="EnsemblBacteria" id="KWX23098">
        <property type="protein sequence ID" value="KWX23098"/>
        <property type="gene ID" value="AFM11_17205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.794"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="194" mass="21093" checksum="52249CA7D1B6E192" modified="2016-06-08" version="1">MARDWLAAKRTEVAADAILDAADELFTRQDAATVGMHEIASAAGCSRATLYRYFENREALYTAYVHREARRLYQEVSEQVGGVTDPAQRLIEGVVTALRAVRESPALSSWFATAQPPIGGEMAEHSEVIRALVEGFVRSLGADGTDDGIGRRARWLVRVMVSLLVFPGGDEADERAMLSEFVAPLVVPAAQATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLB4</accession>
    <name>A0A132PLB4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetate permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Cation acetate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_16600</name>
        <name evidence="8" type="ORF">AWC31_01170</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851004.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01170"/>
    <dbReference type="EnsemblBacteria" id="KWX23145">
        <property type="protein sequence ID" value="KWX23145"/>
        <property type="gene ID" value="AFM11_16600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13395">
        <property type="protein sequence ID" value="ORX13395"/>
        <property type="gene ID" value="AWC31_01170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.669"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX13395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="543" mass="55885" checksum="6A2B5C1B37142783" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLD0</accession>
    <name>A0A132PLD0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-alpha-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_17805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851161.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22802">
        <property type="protein sequence ID" value="KWX22802"/>
        <property type="gene ID" value="AFM11_17805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.916"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="26028" checksum="19D947920CC201E9" modified="2016-06-08" version="1">MTADSNGLSGVVAVVTGGARGLGEAFARHIVGRGGSVVIADVLDDEGTRLAGELGASARYVHLDVTDPAQWSATVEVTRGEFGTLTGLVNNAGVSTGQFIEHEPVEHFRAVLEVNLVGVFNGMQAVIAPMRAAGGGSIVNISSAAGLFGLALTAGYGASKWGVRGLSKVAAVELGTDGIRVNSVHPGMTYTPMTAQVGITPGAGNYPNTPMGRVGMPDEIAGAVGYLLSDAAAYVTGAEIAVDGGWTAGPTVKYVMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLZ7</accession>
    <name>A0A132PLZ7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucarate dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gudD</name>
        <name evidence="14" type="ORF">AFM11_15415</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30612"/>
            <dbReference type="ChEBI" id="CHEBI:42819"/>
            <dbReference type="EC" id="4.2.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate acid metabolism; D-glucarate degradation; 2,5-dioxopentanoate from D-glucarate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.40" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850550.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16360"/>
    <dbReference type="EnsemblBacteria" id="KWX23370">
        <property type="protein sequence ID" value="KWX23370"/>
        <property type="gene ID" value="AFM11_15415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7198"/>
    <dbReference type="UniPathway" id="UPA00564">
        <property type="reaction ID" value="UER00627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008872">
        <property type="term" value="F:glucarate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042838">
        <property type="term" value="P:D-glucarate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03323">
        <property type="entry name" value="D-glucarate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017653">
        <property type="entry name" value="Glucarate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034598">
        <property type="entry name" value="GlucD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00005">
        <property type="entry name" value="glucarate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03247">
        <property type="entry name" value="glucar-dehydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="13">
        <location>
            <begin position="188"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="238"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="342"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR617653-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR617653-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR617653-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX23370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="449" mass="48437" checksum="9A1DD5826786A8C3" modified="2016-06-08" version="1">MSTKTATPVVTGMTVIPIAGHDSMLLNLSGAHGPYFTRNLLVLKDSDGNTGVGEVPGGEAIRRTLDDARPLVEGRSIGEYHAVLASIRRQFADRDSAGRGAQTFDLRVTVHAVTAVESALLDLLGKHLGVPVAALLGDGQQRDRVQALGYLFFVGDRNRTDLPYQSAADEPAGADDWMRIRHDEALSPEAVVRLAEAARARYGFRDFKLKGGVLPAAEEAKAVTALAERFPDARITLDPNGGWLLADAIDTCRQLTDVLAYAEDPVGPEGTFSGREVMAEFKRATGLPTATNMIATDWREMGHAIRGGAVDIPLADPHFWTMSGSVRVAQLCDAWGLTWGSHSNNHFDVSLAMFTHVAAAAPGAITAIDTHWIWQDGQRITKQPYRIVDGYLDVPATPGLGVELDDERVAAAHELYLAKGLGARDDAAAMQYLIPGWKFDSKRPALQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM14</accession>
    <name>A0A132PM14_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23379">
        <property type="protein sequence ID" value="KWX23379"/>
        <property type="gene ID" value="AFM11_15820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7290"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="74" mass="8875" checksum="23C6BC08FC2CC7AE" modified="2016-06-08" version="1">MAEHGGRFADHDWNPWFVLIPITFWTLVIVGIVYLLRRFRGRQGERTLRDAYAKGEVNEAEYRERLAVLRETRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM24</accession>
    <name>A0A132PM24_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09495"/>
    <dbReference type="EnsemblBacteria" id="KWX23400">
        <property type="protein sequence ID" value="KWX23400"/>
        <property type="gene ID" value="AFM11_13975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6898"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="229" mass="24845" checksum="453279CB3CB68D39" modified="2016-06-08" version="1">MRLVSASQRVVAGLKDKIFAGDLPPGQKLPSEAELIEEFGVSRTVVREAVTRLRAEGLVETFQGRGSFVLAVPEPTSFTVESAAIRTHHDVLDMIDFRLGIECEAAALAAARIDDRGGEAVRAALDEFVDAAPEDAVEADFRFHRAVAAVSGNRFYLDLLDSLGPMMIMLPRTRLGDTHSITDAAHAERVRREHGEVAAAVIAGDPDLARAAMRLHLGNTRRRLDAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM62</accession>
    <name>A0A132PM62_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ORF">AFM11_15870</name>
        <name evidence="10" type="ORF">AWC31_16445</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850378.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16445"/>
    <dbReference type="EnsemblBacteria" id="KWX23287">
        <property type="protein sequence ID" value="KWX23287"/>
        <property type="gene ID" value="AFM11_15870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17991">
        <property type="protein sequence ID" value="ORX17991"/>
        <property type="gene ID" value="AWC31_16445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7299"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="195"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="616"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="718"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="203"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX17991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="778" mass="84263" checksum="C3A520909158804F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMI0</accession>
    <name>A0A132PMI0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_14755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849936.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18145"/>
    <dbReference type="EnsemblBacteria" id="KWX23525">
        <property type="protein sequence ID" value="KWX23525"/>
        <property type="gene ID" value="AFM11_14755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7060"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="162"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="297" mass="31464" checksum="AAF62226B5F2018F" modified="2016-06-08" version="1">MQLGLVGLGKMGFNMRERLRAGGHEVIGYDPRPEVTDVANLAELAAALTAPRVVWVMVPSGTITHSTIAELADVLSPGDLVIDGGNSRYTEDGPHAKLLGDKGISFIDAGVSGGVWGLTEGYGLMVGGSDADVARVMPIFDTLRPPGDLADGFVHAGPVGAGHYAKMVHNGIEYGLMHAYAEGYELLAAEDLINDPQAVIQAWSNGTVVRSWLQELLAKALKEDPGFAEISGYTEDSGEGRWTVEEAIAHRVPMPVIAASLFARFASRQDDSPTMKAVSALRNQFGGHAVKRISESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMS5</accession>
    <name>A0A132PMS5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848982.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02880"/>
    <dbReference type="EnsemblBacteria" id="KWX23640">
        <property type="protein sequence ID" value="KWX23640"/>
        <property type="gene ID" value="AFM11_12600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6610"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="124" mass="12662" checksum="7C3CA856D328C652" modified="2016-06-08" version="1">MPNSSPATQAEACCPPGALLREPLSAPAAADIAVKLKALADPVRLQLFSAVASHAGGEACVCDISVGLDVSQPTVSHHLKVLRDAGLLTSERRASWVYYAVVPEALASLSVLLGAVSDTAEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNE2</accession>
    <name>A0A132PNE2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_13690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849475.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23813">
        <property type="protein sequence ID" value="KWX23813"/>
        <property type="gene ID" value="AFM11_13690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6834"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="7">
        <location>
            <begin position="79"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="8">
        <location>
            <begin position="228"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="362" mass="38586" checksum="A1DED5F160C23554" modified="2016-06-08" version="1">MGINVAGMSRYCTIAGVHGVLPPYRYTQEEVTETLLDLPGYAEHEEIVRSLHKSAKVNSRYLVRPIEEYARLSDFGETNNLFIEHATDLGCEALSGALDEAGLRPEDVDLIVTTTVTGAVVPSLDARIAGRLGLRPDVRRIPIFGLGCVAGAAGIARLNDYLRGAPDKVAVLVSVELCSLTRKHHPSMPTLVAGALFGDGASAVVAVGEQRAQELDPSGPDVLDSRSHLYPDSLHAMGWDIGTQGFEIVLSAEVPAFVGRYLGDDVTGFLGDHGLTVGDVGAWVSHPGGPKVIEAIIDTLELPTDALDLTWQSLAEVGNLSSSSVLHVLRDTIRKRPPAGSPGVLMAMGPGFCSELVLLRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNJ0</accession>
    <name>A0A132PNJ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xanthine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_11015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848007.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31240"/>
    <dbReference type="EnsemblBacteria" id="KWX23909">
        <property type="protein sequence ID" value="KWX23909"/>
        <property type="gene ID" value="AFM11_11015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6279"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017588">
        <property type="entry name" value="UacT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03173">
        <property type="entry name" value="pbuX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="OHCU_decarbox" evidence="9">
        <location>
            <begin position="462"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX23909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="634" mass="67294" checksum="C325F3FF7334C784" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNK5</accession>
    <name>A0A132PNK5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_13650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849627.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03895"/>
    <dbReference type="EnsemblBacteria" id="KWX23895">
        <property type="protein sequence ID" value="KWX23895"/>
        <property type="gene ID" value="AFM11_13650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6826"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="222" mass="24306" checksum="550BE2B50800BE4D" modified="2016-06-08" version="1">MSGDAPSLLRLEKTSLREQALSALRRAITTGQLQPGTHLVETDLSEALQISRGTLREAMRQLQQEGLISAGARGRLSVRHLDTKEIKDIFDVRAALESLAASALARREDRAAAVAELRVAVADMERWAASNLEDRIEADLKFHRTMCHLSGNETLLHSWSSLEGSIRMSIMYAGVERALKNMDAKRHLEIVEAIESGDEAAAAATVREHMCTAASVLVDGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNK6</accession>
    <name>A0A132PNK6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_11150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848068.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30750"/>
    <dbReference type="EnsemblBacteria" id="KWX23926">
        <property type="protein sequence ID" value="KWX23926"/>
        <property type="gene ID" value="AFM11_11150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6307"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="341" mass="34862" checksum="944AA9122332012F" modified="2016-06-08" version="1">MRAVVVDNAGAIHVDTRPDPTLPGPDGAIVQVEAASICGSDLHFLEGHYPMAEPVSLGHEAVGTIVETGSEVAKFQKGNRVLVSSVAGCGRCAGCATHDPIKCVQGPQIFGSGILGGAQAELLAVPAADFQLLAMPDGIDTQQALLLTDNLATGWAAAKRADIPIGGTVAVIGLGAVGMCALRSALTLGAATVFAVDPVEARRKRAEAWGATGITAPSARPIREATGGLGADAVIDAVGTDTSINDALDAVRTGGTVSIVGVHDLQPYPLPALACLLRSLTIRLTTAPVQQTWPELIPLLQAGRLDVDGIFTDTLPLDEATAGYAAAMSRSGEHLKVRLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPB1</accession>
    <name>A0A132PPB1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxS</name>
        <name evidence="6" type="ORF">AFM11_11405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30490"/>
    <dbReference type="EnsemblBacteria" id="KWX24170">
        <property type="protein sequence ID" value="KWX24170"/>
        <property type="gene ID" value="AFM11_11405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6358"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="5">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="282" mass="29975" checksum="A1FF928D0D2B55A8" modified="2016-06-08" version="1">MAEMLKGGVIMDVVTPEQARIAEGAGAVAVMALERVPADIRAQGGVARMSDPDMIEAIIDAVTIPVMAKARIGHFVEAQILQSLGIDYIDESEVLTPADYTHHIDKWHFTAPFVCGATNLGEALRRITEGAAMIRSKGEAGTGDISNATTHMRHIGAEIRRLTTLRDDELYVAAKELQAPYELVAEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSGDPAQRAAAIVKATTFHDDPDVLAKVSRNLGQAMVGINVDDIPTPHRLAQRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPC3</accession>
    <name>A0A132PPC3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fructosamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fructosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848766.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09595"/>
    <dbReference type="EnsemblBacteria" id="KWX24143">
        <property type="protein sequence ID" value="KWX24143"/>
        <property type="gene ID" value="AFM11_12385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6556"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="PTHR12149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="255" mass="27517" checksum="BD939BD30E496A95" modified="2016-06-08" version="1">MDEFVKRNPAAPPGFFDAEAAGLRWLAVDGGAECVRVLAHDATSLTLQRLKSVAPSAEAARDLGQRLAVTHDAGAPTFGVGPDGYDGQGFFGPMAHPLPMSLAGRDSWGEFYAEERLRPMARLAAPSMSDATRKAVDAVIELCSTGRFDDDDAPCRLHGDLWSGNVMWTPSGVVLIDPAAHAGHRETDLAMLDLFGCPHLGEILAGYQSIRRLRDGWRDRIGLHQLYPLLAHVVLFGGGYAREVDAIAGRLVKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPF8</accession>
    <name>A0A132PPF8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_11100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31155"/>
    <dbReference type="EnsemblBacteria" id="KWX24164">
        <property type="protein sequence ID" value="KWX24164"/>
        <property type="gene ID" value="AFM11_11100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6296"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="28"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="348" mass="36043" checksum="BDFE5A7E9C039BA9" modified="2016-06-08" version="1">MLNPGWSPGHTAEPRQTDEIRRFHETLPGYAVTPLVPLPTVAGALGLAAVMVKDESLRLGLPAFKMLGASWAVHRALRSADRARPRLITATDGNHGRAVARMGALLNVPATIIVPQGVSERAIELIRSEGADVRVLEVAYDDAVRQAAALADADPDALLVQDTSWPGYEDIPQWIVDGYSTLFDEAADQVAAVGADVDLIVVPAGVGSLAHAAVTFGRSRTHCRVVAVEPVVADCLRASLAAGALTTVPTGQTSMAGLNCGTPSYLAWPDLQKGLAGAVAVDDRQAEQAMATLAELGVDAGPCGAASLAALRILAAEPARSRLGLRTDATVLLLNTEGSSAAGQSASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPI3</accession>
    <name>A0A132PPI3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_09690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847919.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05535"/>
    <dbReference type="EnsemblBacteria" id="KWX24256">
        <property type="protein sequence ID" value="KWX24256"/>
        <property type="gene ID" value="AFM11_09690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5976"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="139"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="330" mass="35088" checksum="2A6BF4A494D7B4A2" modified="2016-06-08" version="1">MTGLRIGVLGASRIAEKAIVGPAQELGHRLVAVAARDPRRAAAFAEKYGVERVLGSYAEVIEDTEVDVVYNPLANALHAPWNAAAVAAGKPVLSEKPFARNRSEAAAVAQAAETAGVTVFEGFHYYFHPVTQRAFALAESGELGRLTHVEVRMAMPCPADDDPRWSLDLAGGALMDLGCYGMHVMRALGRRDIDGLGGEPSVVRARAEERTPGVDASCDVDLAFPGGCTGLSANSMVAEDYSFTIHIAGTDGDALVHDFIRPNDDDRLTVRSAAGTRVERLGTRASYTYQLQAFADHVQHGAPLPFGLTDALANMAYVDAAYRAAGLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ21</accession>
    <name>A0A132PQ21_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_09930</name>
        <name evidence="6" type="ORF">AWC31_05295</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847363.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05295"/>
    <dbReference type="EnsemblBacteria" id="KWX24297">
        <property type="protein sequence ID" value="KWX24297"/>
        <property type="gene ID" value="AFM11_09930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09651">
        <property type="protein sequence ID" value="ORX09651"/>
        <property type="gene ID" value="AWC31_05295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6022"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="4">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="159" mass="17021" checksum="6DC60B33E50D3821" modified="2016-06-08" version="1">MRVYLGADHAGLEFKKTIIEHLEKTGHEPIDCGAYSYDADDDYPAFCIAAAEKTVADPGSLGIVLGGSGNGEQIAANKVPGARCALAWSVETAKLAREHNNAQLIGIGGRMHTTEEALAIVDAFLSTPWSEAERHQRRIDIMAEYERTHVAPPVPGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQG4</accession>
    <name>A0A132PQG4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YtkA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846137.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24425"/>
    <dbReference type="EnsemblBacteria" id="KWX24580">
        <property type="protein sequence ID" value="KWX24580"/>
        <property type="gene ID" value="AFM11_07815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5414"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032693">
        <property type="entry name" value="YtkA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13115">
        <property type="entry name" value="YtkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453196" description="YtkA domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="YtkA" evidence="2">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="135" mass="13886" checksum="2D40481ED0586C73" modified="2016-06-08" version="1">MSRQRLLVTTVVVVAVAAGVGWLLWPTSAAPSAAAVTAGPYQVRLIGDPPKVGTGPVTVEITGSGDEAPTPDTVSFEPAMPQMGHATTPVVATAEGDGRYRGDVDLSMPGQWELTVRITSGTQTHNAVFSVTTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQP5</accession>
    <name>A0A132PQP5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846322.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00100"/>
    <dbReference type="EnsemblBacteria" id="KWX24643">
        <property type="protein sequence ID" value="KWX24643"/>
        <property type="gene ID" value="AFM11_08175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5486"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="396"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="608" mass="68143" checksum="6541C32FADED0FE0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQQ7</accession>
    <name>A0A132PQQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846298.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00055"/>
    <dbReference type="EnsemblBacteria" id="KWX24635">
        <property type="protein sequence ID" value="KWX24635"/>
        <property type="gene ID" value="AFM11_08130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5477"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="503" mass="56366" checksum="BD1F9719534E69E9" modified="2016-06-08" version="1">MSQPSAQSAQVACPVHAEASLHPPRWAPTPVRWQHTEVGYLKSWWLAMKAIRAGYRHTIYEYATELPGQDDIVVARTPLAKFVVVRNPDIARHVLVSNQDNYAKNAEYDLLAVAFGRGLVTDLNDELWQRNRRLVQPLFAKRQVDTFAPQMTAACVAAADRWDRILASGRPVDIAAEMNYVTMDIIARTMFGIELTGKLAEQMRTDFARLLTLFGYGFLLGVARPLRWGADKMSSPRLAINALRRGAWVIAPRARWGLSRIERFIDQLIADHRSGKIERTDNLLALLIAAEDPETGYRYTDLEIRDEVMTFLGAGFETTAAALAWTWYLLSQNPEARQRLGRELDDVLGGREPTADDVDNLPWTQAVVAEAMRVYPPIMGVARMAKGDDILGDYPIKAGTSVAILMHSMHHNARVWGNPHDFNPSRFLKENLDGAQRRAQMPFGAGKRMCIASGFANFEATLIIASLAQRFELDLVPGQRLRRELTFTGGPDGELLMTLRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQS8</accession>
    <name>A0A132PQS8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_08460</name>
        <name evidence="4" type="ORF">AWC31_00315</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000001">
        <property type="protein sequence ID" value="ORX19337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846464.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24691">
        <property type="protein sequence ID" value="KWX24691"/>
        <property type="gene ID" value="AFM11_08460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19337">
        <property type="protein sequence ID" value="ORX19337"/>
        <property type="gene ID" value="AWC31_00315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5540"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453248" evidence="2">
        <location>
            <begin position="29"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX19337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="142" mass="14018" checksum="500ED081F49883F2" modified="2016-06-08" version="1">MKKLVVAGAGAAIAFGAAGLFGAGIAAAAPDVVGQTYEDAASAIEDDGGEPKVAVTVGSKLSQDECVVTNAWDAPFVRDAGDEYEHADGEVMLSLNCDGGYASATNPGASLASPAGREAKAAADEAAAAEEEELAEASTPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRA6</accession>
    <name>A0A132PRA6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24435"/>
    <dbReference type="EnsemblBacteria" id="KWX24582">
        <property type="protein sequence ID" value="KWX24582"/>
        <property type="gene ID" value="AFM11_07825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5416"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453561" evidence="2">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="176" mass="18614" checksum="DC30722072B225B8" modified="2016-06-08" version="1">MKLRAVLAMLCAGVTLAIGAAPAAAADPLDYVVHTEHVQVGPYPVTVGFTVWPLRAMQSLDFTFEPEGGIAGKSGTIATIAPDGGTDVDRLARHPRNRDVWGLDVQSLNSSGTWTLRFTIDGPQGEGTGDLTVDVLKQPGPPLPLSWAIGLIPLTLTLVFFGVVWARTGRRSDAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRD4</accession>
    <name>A0A132PRD4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="11" type="ORF">AFM11_05415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844981.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12790"/>
    <dbReference type="EnsemblBacteria" id="KWX24886">
        <property type="protein sequence ID" value="KWX24886"/>
        <property type="gene ID" value="AFM11_05415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4272"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="164"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX24886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="628" mass="64550" checksum="CFDD7843489FBEC7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRE5</accession>
    <name>A0A132PRE5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urea ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_05505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845005.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12880"/>
    <dbReference type="EnsemblBacteria" id="KWX24900">
        <property type="protein sequence ID" value="KWX24900"/>
        <property type="gene ID" value="AFM11_05505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4291"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017781">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03411">
        <property type="entry name" value="urea_trans_UrtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="26"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="271" mass="28735" checksum="E4AE6D6D8CC35657" modified="2016-06-08" version="1">MTEVEASTAGKEPVEGGNVGMGTQYLEVRGLIVEFDGFKAVSDVDLTLFQGDLRFLIGPNGAGKTTVIDAITGLVPASGSVNKSGVELLGKKVHQIARRGVGRTFQTASVFEQLTVLQNLDIAAGAGRSVWTLMRKRKGVLPVIEQALHTIGLTHLADKPAGILAHGQKQWLEIGMLLVQNADVLLLDEPVAGMSTEEREETGNLLRRIGAERTVVVVEHDMDFMRAFATSVTVLARGQVIAEGSVAEVQANPKVQEVYLGTAAAGVEGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRI0</accession>
    <name>A0A132PRI0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05740</name>
        <name evidence="2" type="ORF">AWC31_11600</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000002">
        <property type="protein sequence ID" value="ORX19209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845084.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11600"/>
    <dbReference type="EnsemblBacteria" id="KWX24939">
        <property type="protein sequence ID" value="KWX24939"/>
        <property type="gene ID" value="AFM11_05740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX19209">
        <property type="protein sequence ID" value="ORX19209"/>
        <property type="gene ID" value="AWC31_11600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4339"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX19209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="210" mass="23038" checksum="71BDCF88894292E8" modified="2016-06-08" version="1">MFARSTTITAHDGPDQRAINAGIAHIRDEVMPALDAVAGCVGLSLMVDRESGRCIATSAWRSEEAMHASAPILAPIRHRAVEVFEGSATVDEWEIAVVHREQYTGPGACVRATWLRARPEQFDRAIEFYRNSVLPSLEELEGFCSASLMLDRSSGRAVSSATFDSAAAMERNRDQARSLRTARLRDLGADQLDVGEFELVLAHLRVPEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRK0</accession>
    <name>A0A132PRK0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_05825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845112.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24953">
        <property type="protein sequence ID" value="KWX24953"/>
        <property type="gene ID" value="AFM11_05825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4356"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="295" mass="31661" checksum="809830A6E4A36F76" modified="2016-06-08" version="1">MDLRSVECFIRVAETLHFGRAATDLHLSQPALSQRIRTLERDVGATLLDRDRRGVRLTAAGLAFLAPARAMLAHGEHAIDVARRAEQGLHGRLRLGFTVVASYTRLPRAVQRFRSTFPDITIDLVEFNSPAVEEALDRGEIDVGVLHPPLARTHLRCRELPDEPLVLALPTDHPLCGHTTIGFGDLAGEALLAAPRSVGPVLFDKLVGCFRSAGVEPDIVQEATPVTTLAGLVAAGAGIGFVTRGVAAASRPGVVFREVVGAPGVPMAIAWTGPKPPPTARRFLDVVDEVWRDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRQ0</accession>
    <name>A0A132PRQ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_06180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845222.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29495"/>
    <dbReference type="EnsemblBacteria" id="KWX25016">
        <property type="protein sequence ID" value="KWX25016"/>
        <property type="gene ID" value="AFM11_06180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4428"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="61"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="316" mass="33511" checksum="9EABBDD205D43E6B" modified="2016-06-08" version="1">MRSITGKSHTDLLLYVAQCYYEQGRTQEDIGSELHLTRWKVGRLLDEARGAGLVEIRIVHPQARRTDVEVEMRSRFGLRECVVVPGPETPDTAGRHIATAAANYLKSNSSWLTTLGVSWGNTLQQIAAVLPAGWTSGIEVIQANGGVSRSVHPTKAANIVTGIAHSGNGRATLLPVPAIVERIETRDALYAEGFVEDVLSRARRAEALLFSLGALGPTSVLVESGAVTPAELAQLESAGACGDILAHYITETGEIAYDDIDRRTVGLSLDDVKNANCAIAVAAGARKVPVVNGALNSGLCSVLITDEPTALAVLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRU8</accession>
    <name>A0A132PRU8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_06315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845263.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29360"/>
    <dbReference type="EnsemblBacteria" id="KWX25040">
        <property type="protein sequence ID" value="KWX25040"/>
        <property type="gene ID" value="AFM11_06315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4457"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="245" mass="25795" checksum="3E75E7511480FB39" modified="2016-06-08" version="1">MSEELRVLAVEAAQRGAAVCLRQLGEPVSAETKTAAGDVVTAVDRSAEEAVRAVLLSARPDDSVLGEELAEHVGAGPLQWVIDPLDGTTNFTRRIPYFATSVAVRTVADGRWLAGAVSAPALGMTWSAAKNLGAIVDSGDGRERLPLPHVATTARLVGTGLSYDPGHRRRQLRELGALMTEYTDMRRFGAAAVDLCLVAQGSLDAFVEDDLGVHDWAAGALIAEEAGAEVRRPAGRDGGVSARWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS71</accession>
    <name>A0A132PS71_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome C oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_07010</name>
        <name evidence="9" type="ORF">AWC31_17705</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845530.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17705"/>
    <dbReference type="EnsemblBacteria" id="KWX25160">
        <property type="protein sequence ID" value="KWX25160"/>
        <property type="gene ID" value="AFM11_07010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17527">
        <property type="protein sequence ID" value="ORX17527"/>
        <property type="gene ID" value="AWC31_17705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4601"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX17527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="349" mass="38044" checksum="36259ADDC673303E" modified="2016-06-08" version="1">MGLQELWFILLAVLFLGFFILEGFDFGVGMLMSFFGRAAQQRGEDSEPYRRAALNTIGPVWDGNEVWLITAGGAMFAAFPEMYATVFSGLYLPLLAILCAMIVRIVAIEWRGKIDDPGWRRWADSGIAIGSFVPAILWGVAFAGLVRGMPVDADKQMHLSIGDVLNAYTLLGGLATGALFALHGAVFVALKTSGAIRSDAFRFAGLLAIPATVLVAGFGLWTQLAYGKSWTWYVLAVAVIAQIAAVTRVYSRRGEGWAFAYTTIVVAAAVILLFGSLFPNLVPSSLNPDWSLTIYNGSSSPYTLKIMTWAALIFAPLVVVYQGWTYWVFSKRISAERIPDPIGLTRRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSJ2</accession>
    <name>A0A132PSJ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_05560</name>
        <name evidence="8" type="ORF">AWC31_12935</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845788.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12935"/>
    <dbReference type="EnsemblBacteria" id="KWX25234">
        <property type="protein sequence ID" value="KWX25234"/>
        <property type="gene ID" value="AFM11_05560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18918">
        <property type="protein sequence ID" value="ORX18918"/>
        <property type="gene ID" value="AWC31_12935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4302"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="53"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX18918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="338" mass="37252" checksum="DFDBB0D15E6DD30B" modified="2016-06-08" version="1">MRWDRQAVKVDDGALPGLQRVGFVRSVRSPQFEGITFHEVLCKSALNKVPAASALPFRFTVNGYRGCSHACRYCFARPTHEYLDLDCGTDFDSQIVVKTNVAEVLRRELRRPSWTHETVALGTNTDPYQRAEGRYGLMPGIIGALADSYTPFSILTKGTLLRRDLGLIAEASRRVDVSIAVSLAIGEADLHHDIEPGTPTPQARLGLITAIREAGLDCHVMVAPVLPYLTDSADQLDALLGRIAAAGATGVTVFGLHLRGSTRGWFMSWLARSHPELTWRYRELYRRGAYLPAEYRDALRARVQPLIRAHGLAAGPRAMSPAPVLGERAPEPVQQTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSK0</accession>
    <name>A0A132PSK0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845565.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17670"/>
    <dbReference type="EnsemblBacteria" id="KWX25167">
        <property type="protein sequence ID" value="KWX25167"/>
        <property type="gene ID" value="AFM11_07045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4608"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045975">
        <property type="entry name" value="DUF5931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19354">
        <property type="entry name" value="DUF5931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5931" evidence="2">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="380" mass="40115" checksum="C3BA74762B84F4B3" modified="2016-06-08" version="1">MQPRPDPVTPLWRAAQVFRLLSCIYALGFQIAVNGDLERPALGWVLCAVLIAWSIACAVAYLKGFGRRTAWVIAEIAVVVVLMLSTEIVATDQWVADNQSWPTTLWATNATISAALQFGPVGGMATGLAVMATAAALKGYVSVNLGRNATIVIELAVGLAVGMAAQTARRAHAELERVARLAAALEERERLSRRVHDGAIQVLALVSRKGREIGGETAQLAELAGEQERALRRLVSATDAEAGSDSGPLTDIGAMLRTRASDRVSISLPAEPVLLEHSTATELFAAAENALDNVAAHAGADACAFVLLEDLGDSVTLSIRDDGAGIPDGRLAEAERQGRLGISKSIVGRMDWLGGSAQLTTGPDCGTEWELTVPRPRKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSM0</accession>
    <name>A0A132PSM0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_03205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843887.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21890"/>
    <dbReference type="EnsemblBacteria" id="KWX25310">
        <property type="protein sequence ID" value="KWX25310"/>
        <property type="gene ID" value="AFM11_03205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2516"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="145"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="358" mass="37515" checksum="55FE19AF9641D91B" modified="2016-06-08" version="1">MAIKVAAIGTGNVGRHALKQLITDPAYELTGVWVSSAAKAGKDAGELAGLDVSTGILATDDLDAVLTTGPECAVYTAMADNRLPDALEDYRRILAAGINVVGSSAVFLQYPWQVLPDELVTPIEEAAKAGAASLFVNGIDPGFANDLLPLALAGTCQQVEQIRCMEIVDYATYDSATVMFDVMGFGKSLDETPMLLQPGVLSLAWGSVVRQLAAGLGIELEAVTEEHTRVPAPEDFEIAAGHIPKGTTAAMRFEVRGMRDGKAAVVLEHVTRLRDDLCPDWPQPAQEGGSYRIELTGEPSYALDLCLSSPNGDHNHAGLVATAARVVNAIPAVVAAAPGIRTTLDLPLITGKGLYAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSM1</accession>
    <name>A0A132PSM1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_06215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845837.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29460"/>
    <dbReference type="EnsemblBacteria" id="KWX25022">
        <property type="protein sequence ID" value="KWX25022"/>
        <property type="gene ID" value="AFM11_06215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4435"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453599" evidence="6">
        <location>
            <begin position="24"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="80"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="296" mass="31039" checksum="8D8525A3955ECBDE" modified="2016-06-08" version="1">MLVVALFAVMLAMALLPGNGVRALLGRDATETQVRAREAELGLDRPVVVRFWEWLSGLVRGDFGTTLRGEPVGDLLAAKVPNSLVLTGVALLVTVVVATLLAVYWTSGERPVFRRIASVGTIVVIALPEFVVATIAILVFALALDVLPAVTVQDSAGAPRDPSMYILPVIALALPQIGWNTRVFVAAIREARSLPYVHAAELDGVGEAALFVRYIAPRALPTMIASLATTVGMIVGGSVVVESLFNFPGVGAVVAGSVNTRDVNVVAAVVACTGVVILLMLLLADATRAWAKARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSP3</accession>
    <name>A0A132PSP3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844015.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25343">
        <property type="protein sequence ID" value="KWX25343"/>
        <property type="gene ID" value="AFM11_03425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2559"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="45"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="252"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="338" mass="36604" checksum="C4E5162CDF5B5C31" modified="2016-06-08" version="1">MTTAETAPVEVSAVVERALFEMKHVVVGQDRMLERLLVGLLANGHILLEGVPGIAKTLAVRTVATVVGGRFHRLQFTPDLMPADILGTRVWRPSSETFEIELGPIFGNLILADEINRAPAKVQSALLEAMAERQVSIGGRSFALPTPFLVLATQNPIETDGVYQLPEAQRDRFLLKVDLTHPNELEEMAILARMGAKPPQPRTLVTTDDVVAMQRATEDVFVHHAVAHYIVRLVMATREPAGYGVGSIAGLLEYGVSPRGSLGLLSASRALALLRGRDYVLPGDVAEIAPDVLAHRLVLTFDAIADGVDPRQVIAEVLDRVPAPQIAPRHAELDEMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSP5</accession>
    <name>A0A132PSP5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="5" type="ORF">AFM11_03235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843902.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21850"/>
    <dbReference type="EnsemblBacteria" id="KWX25315">
        <property type="protein sequence ID" value="KWX25315"/>
        <property type="gene ID" value="AFM11_03235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2522"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00789">
        <property type="entry name" value="KU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="52"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="297" mass="33567" checksum="889E7CC19877BC9A" modified="2016-06-08" version="1">MRSIWKGSIAFGLVNVPVKVYSATEDHDIKFHQVHAKDNGRIRYKRVCEVCGEVVEYRDINKAFESDDGQMVVITDEDIATLPEERSREIEVVEFVPAEQLDPMLYDKSYFLEPDSKSSKSYVLLAKTLAETDRIAIVHFSLRNKTRLAALRVKDFSKRDVMMIHTLLWPDEIRDPDFPVLDKEVQIKPAELKMAGQVVESMTDDFKPDEFRDDYQEQLHELVQAKLEGGEAFAVEEQQPAELDETEDVSDLLAKLEASVKARRGGKEDSKPAKKAPAKKAAAKKAPAKKAAAKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT05</accession>
    <name>A0A132PT05_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Immunogenic protein MPT63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_04230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844435.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20925"/>
    <dbReference type="EnsemblBacteria" id="KWX25469">
        <property type="protein sequence ID" value="KWX25469"/>
        <property type="gene ID" value="AFM11_04230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2723"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015250">
        <property type="entry name" value="MPT63-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09167">
        <property type="entry name" value="DUF1942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453611" evidence="3">
        <location>
            <begin position="37"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1942" evidence="4">
        <location>
            <begin position="38"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="337" mass="32092" checksum="564638B805B80526" modified="2016-06-08" version="1">MNALKIANARTALAAAAIAAAGILASAPVALGDASAVTTATLGSQAKLDNGNVIQGWTVTDLKPSTDAIPYDVRGTLWEVTATDEAIQGSVTPIVSNFNLRGAGGENYRALFQVATPQGVNPATIPQGQKTSGKIYFDVTGAQPTSVVYNAGGRDLLAWDKPAAPAPAPAQSGSRPATSAATPATAAPAAAAEAEGAEATPAPAAAEATPAPAGTEAVPAGAGTRATDLPAATAATPVGTETAPAPAGAEATPAPVAHGTPVAEGAPAPAAVPAGAGNAATAVPPAEVAPVPAGTETVPAAPADPALVPAGVQPTTTVVPVPPAPGTAPASNHGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTM4</accession>
    <name>A0A132PTM4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein LpqT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844897.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21020"/>
    <dbReference type="EnsemblBacteria" id="KWX25691">
        <property type="protein sequence ID" value="KWX25691"/>
        <property type="gene ID" value="AFM11_04135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2705"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019674">
        <property type="entry name" value="Lipoprotein_LpqN/LpqT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10738">
        <property type="entry name" value="Lpp-LpqN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="210" mass="22840" checksum="9938F3ED3CB44DB0" modified="2016-06-08" version="1">MTAVGATAAVLLTGCGAETPDYQSIWTTTTTTTSSSDAPPVPLWQYLENSGVVGEPVAPEDIPDLTITMPTPPGWHPYNNPNLAPRTRMIAKGDTYPTAMLLVFKLHGDFDVPQALKDHGYADAQLSENFKQLNASTDDWRGFPSAMIEGSYDLNGRRMQSYNRVVIPTTVEAPPQRYLIQLTVTTYADEAEAQAADIESIISGFTVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTR8</accession>
    <name>A0A132PTR8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04070</name>
        <name evidence="4" type="ORF">AWC31_21085</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844347.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21085"/>
    <dbReference type="EnsemblBacteria" id="KWX25442">
        <property type="protein sequence ID" value="KWX25442"/>
        <property type="gene ID" value="AFM11_04070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16532">
        <property type="protein sequence ID" value="ORX16532"/>
        <property type="gene ID" value="AWC31_21085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2692"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="22"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="2">
        <location>
            <begin position="444"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX16532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="545" mass="58646" checksum="4586B18A8BFC0E4D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTZ0</accession>
    <name>A0A132PTZ0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844556.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20560"/>
    <dbReference type="EnsemblBacteria" id="KWX25522">
        <property type="protein sequence ID" value="KWX25522"/>
        <property type="gene ID" value="AFM11_04585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2796"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="149" mass="16120" checksum="E39B0DFFAC526208" modified="2016-06-08" version="1">MSIRPALNTALPEAYKSVLALNDQCEKAAADAGLNPLTVELVRIRASQLNGCAFCLRMHVRDALEKGESTDRIAVIPAWRETSYFTAEECAALAIAEEITHIADRATAQSDAERLSALTAAQIAALRWVAVVINAFNRIAISSHYKVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU83</accession>
    <name>A0A132PU83_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Propanediol utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842531.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34020"/>
    <dbReference type="EnsemblBacteria" id="KWX25898">
        <property type="protein sequence ID" value="KWX25898"/>
        <property type="gene ID" value="AFM11_00990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.204"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010254">
        <property type="entry name" value="B12-dep_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003208">
        <property type="entry name" value="Dehydtase/Dehydtase_re"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02288">
        <property type="entry name" value="Dehydratase_MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52968">
        <property type="entry name" value="SSF52968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="190" mass="20600" checksum="38E5B9589B9815F5" modified="2016-06-08" version="1">MSDRTLAFTGETTAEPGKRSDEVVLAISPAFADFFSQTIIGLSHADVIRQILAGIEEQEVGARCIRVRHSSDLAVVAHTAAKLSGSGIGIGILSRGTSMIHQRDLPRLSSLELFPQSPLMTLETYRSIGSNAAQYAKGESPEPVPTLNDQMARPRWQAKAALLHLKETEQIRKNAKPVEVIPQFSEAVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUC5</accession>
    <name>A0A132PUC5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peripla_BP_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25652">
        <property type="protein sequence ID" value="KWX25652"/>
        <property type="gene ID" value="AFM11_03055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2480"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="316" mass="33155" checksum="8094B4C011864181" modified="2016-06-08" version="1">MGVGACGAERTKDPDAAKEIVLLTVSQTCDYCAKHTETFKAAMAAAGVNLRVVVNEFNAADQAQQVNQAISTRPDAMVVWPADSRAIIPSLVRIKKAGIPVVVSNSYPQTTDTTLWTAYTGPNDVANGEAAARAMVETFKAKGFGDSGNIVALLGPPGAPPSIDRLKGFQAEIAKLAPGITVVGTQPGNWDQTLSTTASASLFTQYRGDKLRGMYSEADNMMAGAVVALQRQGIDPSTLAMVGHNCSIEGYNNIESGLQSATVLQSPIEDANLAANATLAILRGEKVDNIQHLVPRPVTRSNLDICTAAVGKDDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUD9</accession>
    <name>A0A132PUD9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_00375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842211.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33490"/>
    <dbReference type="EnsemblBacteria" id="KWX25787">
        <property type="protein sequence ID" value="KWX25787"/>
        <property type="gene ID" value="AFM11_00375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.76"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="299"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="480"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="555" mass="60288" checksum="8C78C2E67E803454" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUK8</accession>
    <name>A0A132PUK8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843013.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34750"/>
    <dbReference type="EnsemblBacteria" id="KWX26038">
        <property type="protein sequence ID" value="KWX26038"/>
        <property type="gene ID" value="AFM11_01970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.403"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="195" mass="21740" checksum="B189A501C313DEDA" modified="2016-06-08" version="1">MTPRIAPLPPKQAGLMTRMMYSFAKRKFGEVPEPFTVAAHHPRLLIANAAHEGLLESGSKKLPANVRELAVFWTARTVGCSWCVDFGSMLMRLDNLDVDRLKSIDDYATSPLFTDDERAAIAYADAMTKDPHTITDEQVADLRRRFGDDGVIELTYQIGTENMRARMYSALGITEQGFNSGDACRVPWADQPEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUV6</accession>
    <name>A0A132PUV6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-hydroxyacetophenone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_01305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842690.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34340"/>
    <dbReference type="EnsemblBacteria" id="KWX25947">
        <property type="protein sequence ID" value="KWX25947"/>
        <property type="gene ID" value="AFM11_01305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.267"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="504" mass="55927" checksum="9D031EBB42A4224D" modified="2016-06-08" version="1">MHTYDTLIVGAGFTGIGTAIKLTEAGVDDFVILDRSDRVGGTWRDNTYPGAACDIPSLLYSFSFVKNPDWSRAYSPADEICRHIEDMVDSFDLRRHIQFGVEVNGLAFDETDGVWTVKTTGRKRFRARTVVLASGPLPDHKWPDIRGLDTYEGHKIHSARWDHDYDFTDKRVAVIGTGASAVQIIPELVKTAGFVKVFQRTPGWVIPRLDIATPPAARTLFSKVPAAQQLARQILFWGHEASATAMVWDTPLTGLVARLGKAHLNRQVKDPWLRRQLTPDFTPGCKRMLVSSDYYPALQRDNCKLIDWPIATMSPVGIRTSDGIEHHLDAVVFATGYDVHLTGPPYPVTGLGGRSLADEWSGGAQAYKSINAHGYPNLFLMTGPNSGPGHNSLLVYVEGQIDYAVTAITTILRNNLRYLDVRADVQQRYNARLQKRLTKTTWMSGCSSWYLTADGFNASMYPGFATQYLRQMRDFRFGDYDAAVRGVSDTASAQDTPVAITSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV25</accession>
    <name>A0A132PV25_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secretion protein EccC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_00890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842474.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33925"/>
    <dbReference type="EnsemblBacteria" id="KWX25882">
        <property type="protein sequence ID" value="KWX25882"/>
        <property type="gene ID" value="AFM11_00890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.184"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="410"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="736"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="433"/>
            <end position="440"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="754"/>
            <end position="761"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="1040"/>
            <end position="1047"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1243" mass="132755" checksum="A1CCE601385484F5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV82</accession>
    <name>A0A132PV82_9MYCO</name>
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        <submittedName>
            <fullName evidence="8">Photosystem I reaction center subunit VIII</fullName>
        </submittedName>
    </protein>
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    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
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        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="AFM11_01560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.319"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="40"/>
            <end position="109"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
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            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KWX26251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="451" mass="50395" checksum="BBA1E4F2E7130B38" modified="2016-06-08" version="1">MSEFLRNAASDLAGGVISPRIFNDPDLYERELARIFARCWCFVAHESEIPEPGDYVLRYIGQDQFIVVRDEDGLIHVLFNKCTHRGSTVCRVEKGNTSHFRCPYHSWVFKNTGEWSGAPYRKSAYKKLDAGNWGLAAAPHVDSVHGLVFAALDPDALTLDEYLGDMRWYLDVLLGLNDSGMTAIGEPHRWRVPANWKSGAENFMADAYHVPSLHRSAEDVGMFPRIETGGAGPQGVSRHVYFEHGHGMIVNNGFLPPPWHTSGYPPEIADTFQLDRLTPLQRQFVENHSATTFLIFPNFGLVRVPAAPHPDAPPMVFTHLRQWQPVGPDGIVNWNWTLGWKTAPAGLNEDAYVAGLSMHGPAGILEQDDTVVWGGAPQAGKSVFAREYGMRFNFQLGLDGMSDYAEDSEWQYPGIATTTALGEAPQRAFYRRWLREMTIPEEERAAKGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB08</accession>
    <name>A0A132PB08_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35535</name>
        <name evidence="3" type="ORF">AWC31_02715</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ORX11067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="KWX19484">
        <property type="protein sequence ID" value="KWX19484"/>
        <property type="gene ID" value="AFM11_35535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11067">
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        <property type="gene ID" value="AWC31_02715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5842"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453134" evidence="1">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="85" mass="8916" checksum="798FAF60EC0BFD4C" modified="2016-06-08" version="1">MLFSGLVAGVLLAGCSPAVTGGDTTCEDFLGQDEKTQNDAVAKMLKDEKGTDAAQLEITGTRLSVQTFCQTAGKQESKIKEAPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB33</accession>
    <name>A0A132PB33_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859728.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19545">
        <property type="protein sequence ID" value="KWX19545"/>
        <property type="gene ID" value="AFM11_35230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5777"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="135" mass="14616" checksum="D6FCB96B026C230D" modified="2016-06-08" version="1">MNAASKPTGLQVGSTRPLSRAERRAQAARVTADETTADETAPAAPEPQNTDTQPAPVVTPPGSEQEAQPAEPVRLKARQRKVKSPFATQLHAGTLARLEWIKAHGYVITDTVDEAINRYLDDAGIPKPDRNDRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBL4</accession>
    <name>A0A132PBL4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859207.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19725">
        <property type="protein sequence ID" value="KWX19725"/>
        <property type="gene ID" value="AFM11_34345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5213"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="71" mass="8095" checksum="EC2190F946B04552" modified="2016-06-08" version="1">MSRLGAVEQAARKERYAAIRRCRYCDPVGWRLQPDGEPIDPAVRCTHSPPAPVRDITEPIHQPDLFSEPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBV5</accession>
    <name>A0A132PBV5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mannan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_33940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000036">
        <property type="protein sequence ID" value="KWX19796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858978.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32510"/>
    <dbReference type="EnsemblBacteria" id="KWX19796">
        <property type="protein sequence ID" value="KWX19796"/>
        <property type="gene ID" value="AFM11_33940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5125"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021992">
        <property type="entry name" value="MVL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12151">
        <property type="entry name" value="MVL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453149" evidence="1">
        <location>
            <begin position="24"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="MVL" evidence="3">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="2">
        <location>
            <begin position="149"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="264" mass="28796" checksum="16F100A5F669DD24" modified="2016-06-08" version="1">MRRTMVGAVAVAVAFATAPSAAASAPTFCDELGGNWDGQFCTTSVVSERKAVRNIKMALPGDLVDNPVIREYLTNLMNNWRNAAKKMVQDSFGEQHFEVFHRGAAMSVVFHEIYSGTFGTDALAHPNAPILSDAYRTFTFAGGRQLQLADLFKPDVDHRAEIPRLGAPFIVAALNAAPPPHQPGTYPFTPDRWTPDKVYSGGYKAWALTPDELILYMPDYPVGRDSPIDFTPGLMQWSMDGGTVQAHIPLSALSPILRPEFGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBY9</accession>
    <name>A0A132PBY9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33850</name>
        <name evidence="2" type="ORF">AWC31_07535</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858906.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07535"/>
    <dbReference type="EnsemblBacteria" id="KWX19839">
        <property type="protein sequence ID" value="KWX19839"/>
        <property type="gene ID" value="AFM11_33850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10031">
        <property type="protein sequence ID" value="ORX10031"/>
        <property type="gene ID" value="AWC31_07535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5108"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="118" mass="12585" checksum="22AAFEFB9D1F0044" modified="2016-06-08" version="1">MSDGSNPRFLQGAFEFEGNGLDKPALIDESLRYVVPPGAVTQPVYFRGGNSTDEMVTVVLYRDGTPMRYFPIAAKGATHVALRVVEDLLGDTVLELFIAAPAACTGSVVVDLGLVEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC06</accession>
    <name>A0A132PC06_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">AFM11_33320</name>
        <name evidence="11" type="ORF">AWC31_02395</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858635.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02395"/>
    <dbReference type="EnsemblBacteria" id="KWX19863">
        <property type="protein sequence ID" value="KWX19863"/>
        <property type="gene ID" value="AFM11_33320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13389">
        <property type="protein sequence ID" value="ORX13389"/>
        <property type="gene ID" value="AWC31_02395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4996"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX19863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="307" mass="33361" checksum="10F7AFCE017D805F" modified="2016-06-08" version="1">MAATLRELRGRIRSAGSIKKITKAQELIATSRIAKAQARVEAARPYATEITNMLTELAGASALDHPLLVEREAPKRAGVLVVSSDRGLCGAYNANVLRRTEELFSLLRDEGKTPVLYVVGRKALGYFSFRQRTVTESWTGFSERPTYEDAKTIADTLVTAFMSGADDEGDDAGADGILGVDELHIVFTEFRSMLSQTAVARRIAPMEVEYVGEAETGPHTLYSFEPDPETLFDALLPRYVATRVYAALLEAAASESASRRRAMKSATDNADDLIKALTLAANRERQAQITQEISEIVGGANALADAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC67</accession>
    <name>A0A132PC67_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858800.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02230"/>
    <dbReference type="EnsemblBacteria" id="KWX19919">
        <property type="protein sequence ID" value="KWX19919"/>
        <property type="gene ID" value="AFM11_33520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5037"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="31423" checksum="DD8FF8D6734C25F4" modified="2016-06-08" version="1">MTMPVMEPQLDAATLRAWAHVIDGGPFSSLCWGERIAFDNPDSLTLLGALAAWTDRVRLVTTVVVPQLHDPVMLAKGLATGDLLSGGRLTVGIGIGGREEDYRAVGADPATQTRQGLAERVAVMKRVWAGEKVTDSTLPVGPPPVQTGGPPLQIGTIGPKTVQDAAAWADGVAGTTLDLDLDKQAELFDIARAAWAEAGKPKPHLATSFWFALGAPDEARAQVHRHLRRYMNWIPAEYVDAMAPITGWAGSEDELVEVLGKFEDIGTDEVHLIPTSANIDQLRRVADVVKIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCA0</accession>
    <name>A0A132PCA0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000033">
        <property type="protein sequence ID" value="KWX19948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858542.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17045"/>
    <dbReference type="EnsemblBacteria" id="KWX19948">
        <property type="protein sequence ID" value="KWX19948"/>
        <property type="gene ID" value="AFM11_33180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4968"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="249" mass="27201" checksum="998BA57D148E3B60" modified="2016-06-08" version="1">MMSVSRAEVCAVACAELFRDAGEIMVSPMTTIVSVGARLARLTFSPDILLTDGEARLIADTPAIGAAAAIEGWMPFGRVFETLAWGRRHVVMGANQIDRYGNQNLSAFGPLQHPTRQMFGVRGAPGNTINHATSYWVGNHSKRVFCDSVDVVSGIGWDKVDPGNSAYRFVNVYRVVTNLGVFDFNGPDHQMRAVSLHPGVEAEQVAENTSFEVHGLADAETTRLATEDELKLLREVIDPKSLRDKEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCS4</accession>
    <name>A0A132PCS4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857750.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20138">
        <property type="protein sequence ID" value="KWX20138"/>
        <property type="gene ID" value="AFM11_31825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4691"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="324" mass="34820" checksum="419E1F9AF5395EDF" modified="2016-06-08" version="1">MTAEPERYPEQRLRAATVRSRLMLEVASTLAGDPDWPAHEVRVDMRAPGGERWSASLSGSDGTDAVDAVLERRSTFAIVNPATAITSALLRRPGTTGNELAAIATVPSYDQLGLAVPAGLGVHTLSDLVEAQPTLTVSLRGNRPNHLVHQVIDDVLAAAGTSLDDLRSWGGVVRYDDGLPHKATRMGLLRDGVVDAIFDEGIYNWAEPAVEAGLRLLSIPDDVIAKLSVIGYRPGVLTTQRFPTLDADVPTIDFSGFLIFTRTDTDDSTVRRFCTALLAARDRIGWQGGATLPLERMCADAIDAPVPIAFHPAAAEVWRANNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD72</accession>
    <name>A0A132PD72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857596.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26215"/>
    <dbReference type="EnsemblBacteria" id="KWX20279">
        <property type="protein sequence ID" value="KWX20279"/>
        <property type="gene ID" value="AFM11_31600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4224"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="27652" checksum="247A3021EE895201" modified="2016-06-08" version="1">MTAPHLDAAGRSPVTLAKSPSWWDPGSECTIVVAEPGMERELWSEYVRGAERNYRKHGVERALDMEALHTGTDTALFCVGINDAGRVVGGLRAKGPYQKTEECHAVVEWSGQAGLDAVRKMVADRLPFGVVEMKTAWVCDDPDQSRALTDTLARMPLHSMTLLNTQFAMATAAAYVLKRWLSSGGVLAAKIPATPYPDERYQTKMMWWDRRTFANHADPKQLSSYFTEAQRVGPRMDDNDDTDTSTAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD95</accession>
    <name>A0A132PD95_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_31645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857619.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26260"/>
    <dbReference type="EnsemblBacteria" id="KWX20286">
        <property type="protein sequence ID" value="KWX20286"/>
        <property type="gene ID" value="AFM11_31645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4233"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="243"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="397" mass="43575" checksum="823418A2BF15BE08" modified="2016-06-08" version="1">MTRLAQTLGLTEFQTEIVSTVRQFVDKEIIPAAQELEHSDTYPQAIVDQMKEMGLFGLMIPEEYGGLGESLLTYALCVEELARGWMSVSGVINTHFIVAYMIRQHGTDDQKQKFLPRMATGETRGAFSMSEPELGSDVAAIRTRATKQADGDYVIDGQKMWLTNGGSSTLVAALVRTDEGADKPHRNLTAFLVEKPTGFGEVVPGLVIPGKLDKLGYKGIDTTELIFDGYHASADDVLGGVTGQGFFQMMDGVEVGRVNVSARACGVGIRAFELAVRYAQQRQTFGKPIAEHQAVAFQLAEMATKVEAAHLMMVNAARLKDSGERNDVAAGMAKYLASEFCSEVTQQSFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKNIISKRLLADYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDD4</accession>
    <name>A0A132PDD4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_30825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857148.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26545"/>
    <dbReference type="EnsemblBacteria" id="KWX20348">
        <property type="protein sequence ID" value="KWX20348"/>
        <property type="gene ID" value="AFM11_30825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4066"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="88"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="428" mass="47900" checksum="86FE6A9550627811" modified="2016-06-08" version="1">MNKDDMILISVDDHIVEPPDMFANHLPKKYVDEAPRLVHNPDGSDTWQFRDIVIPNVALNAVAGRPKEEYGLEPQGLDEIRKGCYNVDERVKDMNAGGILGSICFPSFPGFAGRLFATEDPEFSLALVQAYNDWHIDEWCGAYPARFIPMALPVIWDAEACADEVRRVSKKGVHALTFTENPAAMGYPSFHDDYWTPLWKALCDTNTVLNVHIGSSGKLAITAPDAPLDVMITLQPMNIVQAAADLLWSKPIKDYPDLKIGLSEGGTGWIPYFLERVDRTYEMHSTWTHQNFGGKLPSEVFRDHFLTCFISDPVGVALRNKIGIDNICWEADYPHSDSMWPGAPEELWEVLTENNVPDDEINKMTYENAMRWYSFDPFSHISREQATVGALREAAEGHDVSIRALSHHEKGTRGDALHAAARGNSGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDE7</accession>
    <name>A0A132PDE7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_31405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857491.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25560"/>
    <dbReference type="EnsemblBacteria" id="KWX20247">
        <property type="protein sequence ID" value="KWX20247"/>
        <property type="gene ID" value="AFM11_31405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4187"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="64"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="26455" checksum="37B28FF4E172610E" modified="2016-06-08" version="1">MIQAVDRALRILTVLGGGRRMSLGEIAAAIELAPSTVHGLVRTLLAHGMVQQELDSGRYRLGPATLRLGNVYLDTLELRSRVTIWAENLARRTGCAVRTGVLLFDEVVVVAHEPRPDGTRQMPEVGIVIPAHASALGKALLAFQAERPPVTSLRSMTGETMTDPAALADQLVQVRATGIATEAEEAVLGECSAAAAVFGTTAEAVGAISLVVPAARWPLEPDALDALRDTARTISRELGAPVWPPRPDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDJ5</accession>
    <name>A0A132PDJ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1,4-alpha-glucan branching protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_31165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857319.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26875"/>
    <dbReference type="EnsemblBacteria" id="KWX20406">
        <property type="protein sequence ID" value="KWX20406"/>
        <property type="gene ID" value="AFM11_31165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4137"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037090">
        <property type="entry name" value="57_glycoside_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015293">
        <property type="entry name" value="BE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040042">
        <property type="entry name" value="Branching_enz_MT3115-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41695">
        <property type="entry name" value="PTHR41695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09210">
        <property type="entry name" value="DUF1957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="4">
        <location>
            <begin position="15"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1957" evidence="5">
        <location>
            <begin position="431"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="515" mass="57199" checksum="4C9D51094CBBFC84" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDN9</accession>
    <name>A0A132PDN9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20451">
        <property type="protein sequence ID" value="KWX20451"/>
        <property type="gene ID" value="AFM11_30170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3930"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="181" mass="19753" checksum="0A366F90EF588597" modified="2016-06-08" version="1">MSLNKLLAYAPPAKAAQAALVMARATLNEPDVPEKTQQIAQQLIELGEDDLAERIRIRREQAVAADLRAMLSGAETGQATTPADTDDEGDEGLAVDVVELQPLVATEDVHFETEPPVGESTKRPAAQGIRAEGLGRLNRASLDRQQSAAIRDWARRRGMRVSTRQQIPADVVDKFIRDHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDP7</accession>
    <name>A0A132PDP7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_30875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857164.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26595"/>
    <dbReference type="EnsemblBacteria" id="KWX20357">
        <property type="protein sequence ID" value="KWX20357"/>
        <property type="gene ID" value="AFM11_30875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4077"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="253" mass="25461" checksum="299C96876EA54A45" modified="2016-06-08" version="1">MTFADIALLFVAGIAGGLAGSIAGLASVATYPALLLVGLPPVTANVTNTVAMVFNGIGSVWGSRPELAGQGAWLKRIIPIAVIGGAAGAALLLCTPAEGFEKVVPFLLAFASVAILLPRKEHREARVASHRDHVIKVLVEAGAIFLITIYGGYFGAAAGVLLLALLLRAGGATLPHANAGKNVLLGVANSVAALAFAVFAPVHWAAVAPLGVGCLIGSRLGPIVVRHAPATPLRVLIGAAGVTLAVKLALDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDQ1</accession>
    <name>A0A132PDQ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857187.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26630"/>
    <dbReference type="EnsemblBacteria" id="KWX20424">
        <property type="protein sequence ID" value="KWX20424"/>
        <property type="gene ID" value="AFM11_30910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4084"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="412" mass="43176" checksum="A11EC342830D57A9" modified="2016-06-08" version="1">MKGQSPKQVSLLAGATLIDGSVVDVELGRDGDHAVVTRVTPAAADRDDEATVDLRGYLLMTAPAEPHAHLDKALSWDTLRPQLTDLHGAIASWRQGSAAFDEESFRDRAATAALALVRNGTTAVRTHVDILPTGDPLRGVRAVAAVREQLRHLIDIEIVALLKDYSGADLLHAALDAGADLVGGSPHSTADPHAELGRLLDVAELRGVGADLHTDEFLVGDHHTIAQYAQRARDWPVDRIRTASHCTRLGTMTADELAGLLPRVAEAGIGVVANPITNLYLQGRDHPVATPRGLTAIAALREAGVPVAAGADNVRDPFNPLGRSDALETAALAVIAGHVHPEVAIAMVTDDARRVMGLPAAGPRAGARAEMLAVRGAGLLEVLATAPADRVVIHDGAVVSVSETRTWTACTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDX7</accession>
    <name>A0A132PDX7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_30440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20531">
        <property type="protein sequence ID" value="KWX20531"/>
        <property type="gene ID" value="AFM11_30440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3988"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="194" mass="20765" checksum="23DC078B62E36C75" modified="2016-06-08" version="1">MVARFTRRTALTAAGVGALVGVGYALSRAVDPGPPAIRLTDDGNGGDGGMMGPGMMGGATQADMGIYMEMFRRHNEIRRVVEEIPGGVRTTTESDAPELVAQLQAHLSSMYHHLEQGAEVMCMSASLPTLFRRADGYRRQLTFTANGVIAEETAEDAELVRSIRDHAREVTGFVDKGMPAMMEGMMGGGMMGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PED5</accession>
    <name>A0A132PED5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20690">
        <property type="protein sequence ID" value="KWX20690"/>
        <property type="gene ID" value="AFM11_29140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3712"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="395" mass="43875" checksum="EF2532CA5E95714A" modified="2016-06-08" version="1">MFLKWASDQGIGSLDSLTADDWSNFVSWVRDAYPDTTPQSRNSRLAAVRVLLAQYGALSYEFGQALAQRYSEINENVHPDHYTASELQQIRSAATRALRTAWRRIEPNWALAQRPKESVPAEQRARWEALQALLRAPHKSLRKEDGHALGVLDQHRNVQMEEARCLLFLATNEGLAAYGAIVAATGENSSTTSRRRTPSTAASAGSESITIFTSERDKRRRSGGKSLMAENAAVTSPLGKLLQLVMDCTAPARHSAHLNPEALLDSHAGAHQSVKDSSSESLILFMRRNGALVNSVSHVPKSLDWMPSGLHLDLRRLHRTYLTRVAQHPVDNRYLTWIDAYILKDPKRIQELEDIHRAAQQKALDAVRGLAVRLLTEEEAAKEGLNTAPTAKGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEE1</accession>
    <name>A0A132PEE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040655.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20706">
        <property type="protein sequence ID" value="KWX20706"/>
        <property type="gene ID" value="AFM11_29255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3736"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="256" mass="26647" checksum="06AA2EA68170133E" modified="2016-06-08" version="1">MMASRVLLTPMRGVGDFFAMSLDTFVQMFRPPFAWREYLSQTWFVARVSMLPALMLTLPYSVLLVFIFSILLTEFGAADFSGTGAAIGTVNQIGPIVTVLVVSGAGATAMCADLGARTIREEVDALRVMGINPIQALVVPRVLAATTVSLALASTVILVGLTGAFFFVVSIQHVSPGAFVAGLTVLTGAADVVVSLTKAMLFGLAAGLIACYKGISVGGGPAGVGNAVNETVVFTFMVLFAINVIVTAVGIQFTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEF9</accession>
    <name>A0A132PEF9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_29300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040638.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20713">
        <property type="protein sequence ID" value="KWX20713"/>
        <property type="gene ID" value="AFM11_29300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3748"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="238"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="395" mass="43179" checksum="CC3F6C3114D17899" modified="2016-06-08" version="1">MTTPALDQLTDAQQELVERAHLIAGTELRPHAAEWDRRQEFPERSYQILRENGFTGLTVPTEYGGRGLGVFEACLVLEELAVGCMASALTIQMQLNGPPRVIARMGSEQQRQQYLPEVVDGTRRFAVAMTEPQAGSDGTALATTLAPDGDDFRLTGAKCHITGALQAHTFLVFCRAPETNGPDGIGAVLVDADVEGLAPIETEEKMGGRGVAEGVLRFTDAPVRRDQVILEPRPGSKEGASFLIRQFNPERCGNAAMSIGVARAALEDAVEYAKEREQFGRPILEFQGIQWKIADMATELDAARLLLWRAARTDVAGFPGIRETAMAKLYANEAAVRVCNEAIQLLGHKGYLTRYPMERYFRDVRGMGIGGGTTEILRNMIAAEVTGVRTSQRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEJ8</accession>
    <name>A0A132PEJ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25190"/>
    <dbReference type="EnsemblBacteria" id="KWX20647">
        <property type="protein sequence ID" value="KWX20647"/>
        <property type="gene ID" value="AFM11_29850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3862"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025597">
        <property type="entry name" value="DUF4345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14248">
        <property type="entry name" value="DUF4345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="119" mass="12278" checksum="5933F2ABAF22450C" modified="2016-06-08" version="1">MAVIVVVGVFFLGMGVYALAAPQAMLRPFDYTLKTGASRAEVRGVYGGFGLAISAVLVYAAATPGDIRTGILVTVGAALAGMAVGRSVSAVVDERTAFYPNWFYCLVEVVGAAALIWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEN0</accession>
    <name>A0A132PEN0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_28560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856171.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32825"/>
    <dbReference type="EnsemblBacteria" id="KWX20790">
        <property type="protein sequence ID" value="KWX20790"/>
        <property type="gene ID" value="AFM11_28560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3591"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453034" evidence="2">
        <location>
            <begin position="30"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="3">
        <location>
            <begin position="494"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="776" mass="82114" checksum="56D6F21D1945824B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEN4</accession>
    <name>A0A132PEN4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_29125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040129.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20687">
        <property type="protein sequence ID" value="KWX20687"/>
        <property type="gene ID" value="AFM11_29125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3708"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="135"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="378" mass="41084" checksum="FFE0EAB33409F633" modified="2016-06-08" version="1">MILPAVTASAELPDLPVDVVERIRSAAIDSQSPGTRRAYASAWRRFEWWCRRNGHQSLPAHPTVIAAYLVDAAETVDERGVRAYSTQSVGKWTAAIADRHRRAGLEPNPASHELVRQTMSGVKRQYASRGDRPRMPRTPLLTDDVMLLVTAARAQATGWVSEVYERRDSALLLMGFAGAFRRSELSALTGGDVELHAADGVHVYVRRSKTDQEGQGAVYPLPRTKDPLRCPACAFVRWAQVVSAFDDGGKDAVIRLVSDSPEFGSRHVCRSRAPKLAPRLPLFRSIRPGGKIANSALSGAGVHAVIRRRALRAGCDPEAVERLGGHSLRAGFVTQAAGAGADHHSIMRQTGRRTPAMVTRYVRESAPLIGNAVTVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF02</accession>
    <name>A0A132PF02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856359.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20854">
        <property type="protein sequence ID" value="KWX20854"/>
        <property type="gene ID" value="AFM11_28565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3592"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="76" mass="8314" checksum="D7F736DA6CA0BB85" modified="2016-06-08" version="1">MPADLGPDPVIADLLSGASLRELAHARDDLERAQERYDNAVLAGRKAGLSWGEIGEILGVSKQKLHSRYRSRDLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PF15</accession>
    <name>A0A132PF15_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855769.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10460"/>
    <dbReference type="EnsemblBacteria" id="KWX20920">
        <property type="protein sequence ID" value="KWX20920"/>
        <property type="gene ID" value="AFM11_27940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3462"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="260" mass="28207" checksum="D419496B3F42B9BC" modified="2016-06-08" version="1">MGILFGFAPWIIYWVLVGNVPFLVAVLVALVAAIATFVISRISGNPGRTLEIGALATFVVLTVVTLVLSQDVMERWMQPLSNVGIFLVALVGALIGKPFVQEFAAAGQPPGVVESDLFKRIVTILTWIWVAAFAGMTISSAIPPLVQGDATILDTKTPLSFICYWVIPFTLLGLAALASRILPDRMTAGMNDIVRKTTFVAYSEAAIDELYYLAQEHANREVGAGQEAYDVRVGGSGTPLLGDESRMSWPSTYKVRDRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFH2</accession>
    <name>A0A132PFH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06785"/>
    <dbReference type="EnsemblBacteria" id="KWX21024">
        <property type="protein sequence ID" value="KWX21024"/>
        <property type="gene ID" value="AFM11_26935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3261"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="104"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="537" mass="56220" checksum="27CDBBEB735FF403" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFS3</accession>
    <name>A0A132PFS3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26510</name>
        <name evidence="3" type="ORF">AWC31_22825</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854962.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22825"/>
    <dbReference type="EnsemblBacteria" id="KWX21209">
        <property type="protein sequence ID" value="KWX21209"/>
        <property type="gene ID" value="AFM11_26510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15423">
        <property type="protein sequence ID" value="ORX15423"/>
        <property type="gene ID" value="AWC31_22825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3172"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX15423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="143" mass="15387" checksum="733627167E458DE5" modified="2016-06-08" version="1">MRADLGVDTIVTLLAAGLIFLLALILGIWKYRQMATSENHLAHPYVDIAHRAALLYSFATLLVAVFVELSAWPTWVNLAAAMVLVFFFVIAIVSYIEHGAKQDTTNQFGQPSFGLHAGMVALIVGEVGGFAVLLAGFVAAQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFU4</accession>
    <name>A0A132PFU4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Copper resistance protein CopC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_26550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854982.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22785"/>
    <dbReference type="EnsemblBacteria" id="KWX21216">
        <property type="protein sequence ID" value="KWX21216"/>
        <property type="gene ID" value="AFM11_26550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3180"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453217" evidence="4">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="5">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="168" mass="17109" checksum="FE17AA30974A5C1F" modified="2016-06-08" version="1">MRRLLAMTLTTLALAASALAGAGTASAHATRTGADPAEHAKLTESPQRVSATFNEQLQKAFAAMTVVGPDGNLWSDGEPQVEGAVVSVGVRPLGPAGTYNVNYRVTSADGHVVSGSWAFELTVEGTGTPGPAAAAPSSSDEGLPVWPFVLAAVVIVGGGAWWAVRRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFV7</accession>
    <name>A0A132PFV7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854978.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21215">
        <property type="protein sequence ID" value="KWX21215"/>
        <property type="gene ID" value="AFM11_26540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3178"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="163" mass="15838" checksum="12A6130CEC724FE3" modified="2016-06-08" version="1">MAEQPDQPAEKPDTPAGSAPAGPSGAGDDSAAATPPAPATPPAKKAPAKKAPAKKAPAKKAPAKAAKKAPAKKAPAKKAPAKKAPAKKAPADIPPPEVLTAAAEETAAQAKSTVAAAGNPVSGPAPVPLETPAQSRLPLAAAVAVGLLAILLVVVTRRHSTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG02</accession>
    <name>A0A132PG02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_27090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855558.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06935"/>
    <dbReference type="EnsemblBacteria" id="KWX21137">
        <property type="protein sequence ID" value="KWX21137"/>
        <property type="gene ID" value="AFM11_27090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3292"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="352"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="518" mass="54598" checksum="3F37248C68C51782" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGI3</accession>
    <name>A0A132PGI3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-seryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5">2.9.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenocysteine synthase</fullName>
            <shortName evidence="5">Sec synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">selA</name>
        <name evidence="8" type="ORF">AFM11_26025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22728"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SelA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.1" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854631.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35875"/>
    <dbReference type="EnsemblBacteria" id="KWX21374">
        <property type="protein sequence ID" value="KWX21374"/>
        <property type="gene ID" value="AFM11_26025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3069"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004125">
        <property type="term" value="F:L-seryl-tRNASec selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00423">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004534">
        <property type="entry name" value="SelA_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025862">
        <property type="entry name" value="SelA_trans_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12390">
        <property type="entry name" value="Se-cys_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00474">
        <property type="entry name" value="selA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Se-cys_synth_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX21374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="425" mass="43722" checksum="1272A6EEB457C1CC" modified="2016-06-08" version="1">MTDPRRRVPRSDTLLADPRLAEAERTLGRALVKTVIAEAQQKARSGEIAPDRVADVAVAALPSSASSLRPVINATGVVVHTNLGRAPLSTAAIDAVVTASGATDVEFDLQTGRRARRGRGAMAALARAVPTAGGVHVVNNNAAALLLTAMTLAPGKEMIVSRGELIEIGDGFRLPALMESTGSRIREVGTTNRTHLRDYADAIGPDTGFVLKVHPSNYAMTGFTSSVPVAELATLDAPLVVDIGSGLLTPHPLLPDEPDATTVLGDGADLVTASGDKLLGGPQAGLLFGGAELIERLRRHPAARALRVDKMTLAALEATLTGPPPPVAEALRVDVESLRIRAARLAARLPDADAVDCIAAVGGGGAPGVALPSAAVSLPEAYAAPLRMGTPAVVGRLENGRCLLDLRTVAEADDDTLAHAVLACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGL0</accession>
    <name>A0A132PGL0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855546.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21132">
        <property type="protein sequence ID" value="KWX21132"/>
        <property type="gene ID" value="AFM11_27015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3276"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046282">
        <property type="entry name" value="DUF6319"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19844">
        <property type="entry name" value="DUF6319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="122" mass="12542" checksum="F28DBE576FA3028D" modified="2016-06-08" version="1">MHTDSSTDSGTSDAPAPAAETPKRATAKKAAGKRTKTLELTLTVTGTADGEWTAELKQGSTYLARNLAVAAAAVSRAAKELHEDLSTPIDAVIEEARAQQAAKVAALEAELEAAKKALADLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGU4</accession>
    <name>A0A132PGU4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_25450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854321.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27810"/>
    <dbReference type="EnsemblBacteria" id="KWX21550">
        <property type="protein sequence ID" value="KWX21550"/>
        <property type="gene ID" value="AFM11_25450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2453"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043641">
        <property type="entry name" value="PPE-PPW_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18878">
        <property type="entry name" value="PPE-PPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PPE" evidence="4">
        <location>
            <begin position="8"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PPE-PPW" evidence="5">
        <location>
            <begin position="459"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="519" mass="52759" checksum="CAE87BDDB608720C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHF4</accession>
    <name>A0A132PHF4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mycobactin import ATP-binding/permease protein IrtA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFM11_24610</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a heterodimer with IrtB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. Siderophore-Fe(3+) uptake transporter (SIUT) (TC 3.A.1.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853824.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23510"/>
    <dbReference type="EnsemblBacteria" id="KWX21694">
        <property type="protein sequence ID" value="KWX21694"/>
        <property type="gene ID" value="AFM11_24610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2283"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="15"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="303"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="617"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="244"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="650"/>
            <end position="657"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KWX21694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="863" mass="93239" checksum="C1B45F9BCC0AE480" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHM3</accession>
    <name>A0A132PHM3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-lactamase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_23465</name>
        <name evidence="2" type="ORF">AWC31_28190</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000017">
        <property type="protein sequence ID" value="KWX21811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX15011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853204.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28190"/>
    <dbReference type="EnsemblBacteria" id="KWX21811">
        <property type="protein sequence ID" value="KWX21811"/>
        <property type="gene ID" value="AFM11_23465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15011">
        <property type="protein sequence ID" value="ORX15011"/>
        <property type="gene ID" value="AWC31_28190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2048"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX15011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="238" mass="25525" checksum="5A189DB2657AFBDF" modified="2016-06-08" version="1">MDTTVDEIAPDIYRLSTWVPGITEHGFTFNQFLLTGDEPFLFHTGMRHLFGSVSAAIERVLPVEKLRWISFGHLEADECGAMNELLAAAPNAEVIHGPLAIMLSLADLCDRPPVAAPDGVHDIGGHRLRFIATPHIPHNWEAGLWFDETTSTLLAGDLFTHTGRCPALTESDCVAPALDAEGLFHATGLTTNLVPTLNELAERNPTTLAIMHGASYHGDGAAQLRALADGYAGLLGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHV9</accession>
    <name>A0A132PHV9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23940</name>
        <name evidence="4" type="ORF">AWC31_24215</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853503.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24215"/>
    <dbReference type="EnsemblBacteria" id="KWX21592">
        <property type="protein sequence ID" value="KWX21592"/>
        <property type="gene ID" value="AFM11_23940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15655">
        <property type="protein sequence ID" value="ORX15655"/>
        <property type="gene ID" value="AWC31_24215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2146"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="2">
        <location>
            <begin position="11"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX15655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="262" mass="27968" checksum="3DD14A780B028F3C" modified="2016-06-08" version="1">MNHHHVHHFDMGLWLLFLAYIVSVTGSVVGLACTRCGARAATERDRLRWLLMAAIAIGGVGIWLMHFIAMLGFAIPNSVVRYHLGWTVASAVLAIAAVFAGLVTIGRTFDLRRLIAGGVITGLAVALMHYTGMWAMQIQGTIAYDKFLVALSFLIAVVAATAALWFTLVLKSPVLRFAAGLVMGVAVVGMHYTGMAAVRVTVDRTVPVPGGPEAFSFLFPVFVIGLLALVIPITAIMLASDRNTDDTDAEARAVAATGGRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI38</accession>
    <name>A0A132PI38_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_22715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852816.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08490"/>
    <dbReference type="EnsemblBacteria" id="KWX21973">
        <property type="protein sequence ID" value="KWX21973"/>
        <property type="gene ID" value="AFM11_22715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1895"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453310" evidence="2">
        <location>
            <begin position="25"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="46"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="340" mass="35801" checksum="043A996943CD02A4" modified="2016-06-08" version="1">MSASSRRFAALLLVAGLLTGCVSRQDNSAPQQAPATVPLSELAGVTLQIGDQKGGTEALLRAAGALDDLPYRVAFSTFTSGPPQIEAATAGKIDFAITGNTPPIFGAASNAKVKVVSAYDGGGFGDQILVHADSPIQTVAGLRGKSIAIAKGSSAHGHTLVQLSRAGLSPADVKLVFLQPADALSAFTQRRVDVWAVWDPYTAQAEKELPVRSIARATGVTNGAGFGVASDAALADPKRNTALADLLVRYAKAVRWANDHRDQWVSRYAAEVGLDPAVATVAQGRSLRLPTDLSDQLIASEQEMADLFAQSGQIAAAPEFANWVDRRFTDQLRPLYLNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI50</accession>
    <name>A0A132PI50_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22480</name>
        <name evidence="3" type="ORF">AWC31_08730</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852736.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21934">
        <property type="protein sequence ID" value="KWX21934"/>
        <property type="gene ID" value="AFM11_22480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10236">
        <property type="protein sequence ID" value="ORX10236"/>
        <property type="gene ID" value="AWC31_08730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1846"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453271" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX10236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="150" mass="16006" checksum="7092F088DAFBAF83" modified="2016-06-08" version="1">MTDAMMITALCLLCGGAASAVLAAARRTRCARPDDEATERLATIEELVAEFDLMLIRKGLLTSTQLALIRNGIRSRGIVTGMRPTGAMREDFREVELDLMVSRPGGGQFPAHQTALIPASSLRKVTPGSVIDTYFRPGDESAIAVCVSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIN7</accession>
    <name>A0A132PIN7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04775"/>
    <dbReference type="EnsemblBacteria" id="KWX22228">
        <property type="protein sequence ID" value="KWX22228"/>
        <property type="gene ID" value="AFM11_21970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1742"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="31"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="197"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="331" mass="34988" checksum="52451239F9D52D13" modified="2016-06-08" version="1">MTTTDRTTDIVPGVRVNAHQAADLLSEASSVSVVCHVYPDADTIGAGLALAQVLEGAGKQVEVAFAAPAELPESLQTLPGGHLLVAPETMRDDADLVVTVDIPSVNRLGALRDLAEDGRPVLVIDHHASNQLFGSANYVDPTADSTTMLVAELLDAWGKPIDEQVAHCLYAGLTTDTGSFRWATARAHRLAARLVELGVDNAAISRTLLDTHPFAWLPMLSRVLASARLLPDAVDGRGFVYAVVAHSEWASARPEEVESIVDIVRTTQQAEVAAVFKEIEPMHWSVSMRAKSVNLAQIASSFGGGGHPHAAGYSATGRADDVVQALTQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ27</accession>
    <name>A0A132PJ27_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852233.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06605"/>
    <dbReference type="EnsemblBacteria" id="KWX22346">
        <property type="protein sequence ID" value="KWX22346"/>
        <property type="gene ID" value="AFM11_21240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1594"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="244" mass="25239" checksum="0CDD4C3CEA89AB77" modified="2016-06-08" version="1">MTLDGKVALVTGASSGLGAAVAQLFAARGASVFGIARDAERMAAVFDDVPGGKYASVDISSSEACGQAVARCVEEFGRLDTLINVAGFHQMRHTLSVTDDDWDKDLAVNLNGPFFLCRAALPHLFDGGSIVNVASIAGIEGEVYSAGYCAAKHGLVGLTRALAIEFTSNRLRVNAVCPGGMLTPQTTEFAAPDNADWNLIMRIAAPRGMMDVADVAKTIAFLASDDAAAVHGAVYVVDAGKTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJC9</accession>
    <name>A0A132PJC9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_20915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852122.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06335"/>
    <dbReference type="EnsemblBacteria" id="KWX22297">
        <property type="protein sequence ID" value="KWX22297"/>
        <property type="gene ID" value="AFM11_20915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1524"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="252"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="509" mass="54970" checksum="F4D3EB36619AB9E6" modified="2016-06-08" version="1">MTAQRQVDADFLGLPRFELADAALSAAVAAGASYADLRIHRITTELIQLRDGELETSVITREIGLAVRVIVDGTWGFASHAELDATVAAATARRAVEVATTLSQLNGERIELAPEPVYTDVTWVSEYGIDPFTVAAADKIAVLDDYSGRLLAADGVDHVSAGMHAVKEQTFYADTFGSSITQQRVRVLPTLEAVSVDSAAGSFETMRTLAPPTARGWEAVADDGVWDWTSELAELPSLLAEKTKAPTVVAGPTDLVIDPSNLWLTIHESIGHATEYDRAIGYEAAYAGTSFATPDKLGTMRYGSEVMNVTADRTVEFGLATVGFDDEGVRAQSWDLVRDGIFVGYQLDRVFALRIGRGLGEARSNGCSYADSPHHMPIQRMANVSLQPGPDDLSTEDLISRVADGLYIVGDKSWSIDMQRYNFQFTGQRFYRIRDGRLDGQVRDVAYQATTTDFWGSMEAVGGPSTWRLGGAFNCGKAQPGQVAPVSHGCPSALFRGVNVLNTRTEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJP6</accession>
    <name>A0A132PJP6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_18680</name>
        <name evidence="7" type="ORF">AWC31_22415</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851490.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22415"/>
    <dbReference type="EnsemblBacteria" id="KWX22551">
        <property type="protein sequence ID" value="KWX22551"/>
        <property type="gene ID" value="AFM11_18680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15352">
        <property type="protein sequence ID" value="ORX15352"/>
        <property type="gene ID" value="AWC31_22415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1073"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX15352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="264" mass="28763" checksum="FD7A4036B45D0FB5" modified="2016-06-08" version="1">MSDPHISTRDAWVEFPIFDAKSRSLKKAFLGKAGGAIGRNESNVVVIEALRDITMSLEMGDRVGLVGHNGAGKSTLLRLLSGIYEPTRGSATVTGRVAPVFDLGVGMDPEISGFENIIIRGLFLGQTRKQMLARVDEIADFTELGDYLSMPLRTYSAGMRVRLALGVVTSIDPEILLLDEGIGAVDAEFLKKAQTRLQDLVERSGILVFASHSNEFLARLCKTAMWIDHGTIKMTGGIEDVVRAYEGDDAARHVREVLEETARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJS9</accession>
    <name>A0A132PJS9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_18765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851517.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22310"/>
    <dbReference type="EnsemblBacteria" id="KWX22563">
        <property type="protein sequence ID" value="KWX22563"/>
        <property type="gene ID" value="AFM11_18765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1090"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025568">
        <property type="entry name" value="DUF4334"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025951">
        <property type="entry name" value="GXWXG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14232">
        <property type="entry name" value="DUF4334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14231">
        <property type="entry name" value="GXWXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXWXG" evidence="1">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4334" evidence="2">
        <location>
            <begin position="94"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="153" mass="17198" checksum="7DCB159D97EA724D" modified="2016-06-08" version="1">MADARATFDDFTKREGQIPDAELDALWAVLTPVSIDFMIGEWQGGEFQTGHKANGFMKRLNWFGKTFNSPSDAKPLVCLDADGNKFSNTEAMNGEASLWLEEFRGEVTATMVYDGRPVHDHFKKVDDNTVMGIMNGKGAVVDGRYLYFYLQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK09</accession>
    <name>A0A132PK09_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_21285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852244.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06660"/>
    <dbReference type="EnsemblBacteria" id="KWX22352">
        <property type="protein sequence ID" value="KWX22352"/>
        <property type="gene ID" value="AFM11_21285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1603"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="588" mass="59959" checksum="49373152F48F513D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK21</accession>
    <name>A0A132PK21_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 17">Aspartokinase</fullName>
            <ecNumber evidence="7 17">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFM11_19545</name>
        <name evidence="21" type="ORF">AWC31_15615</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7 17"/>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851769.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15615"/>
    <dbReference type="EnsemblBacteria" id="KWX22686">
        <property type="protein sequence ID" value="KWX22686"/>
        <property type="gene ID" value="AFM11_19545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17849">
        <property type="protein sequence ID" value="ORX17849"/>
        <property type="gene ID" value="AWC31_15615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1242"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="12 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="267"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KWX22686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORX17849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="421" mass="44436" checksum="A854FDE91D47676A" modified="2016-06-08" version="1">MALVVQKYGGSSVSDAERIRRVAERIVETKKAGNDVVVVVSAMGDTTDDLLDLARQVSPAPPPREMDMLLTAGERISNALVAMAIESLGAQARSFTGSQAGIVTTGTHGNAKIIDVTPGRLRDALDEGVIVLVAGFQGVSQDSKDVTTMGRGGSDTTAVALAAALNADVCEIYTDVDGIFTADPRIVPNARHLDTVSFEEMLEMAACGAKVLMLRCVEYARRYNVPIHVRSSYSDKPGTIVKGSIEDIPMEDAILTGVAHDRSEAKVTVVGLPDVPGYAAQVFRAVAEADVNIDMVLQNISKIEDGKTDITFTCSRESGPGAVEKLTALKEEIGFSQVLYDDHIGKVSLVGAGMRSHPGVTATFCEALAEVGVNIDLISTSEIRISVLIKDTELDKAVAALHEAFGLGSDDEAVVYGGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK32</accession>
    <name>A0A132PK32_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-TFIIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851479.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22445"/>
    <dbReference type="EnsemblBacteria" id="KWX22547">
        <property type="protein sequence ID" value="KWX22547"/>
        <property type="gene ID" value="AFM11_18650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1067"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="113" mass="12560" checksum="7564CF423C6DFB70" modified="2016-06-08" version="1">MSIPPYEPPKTPPTHGVGNNLLCPKCAGVMKTYERNGIHLEQCDTCRGIFLDFGELEALTQMENRFVQSAPPPPPPHSGYGQSYGHANYGPGWGHRGNKHYRKQGFGRLFFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKR0</accession>
    <name>A0A132PKR0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851237.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12105"/>
    <dbReference type="EnsemblBacteria" id="KWX22834">
        <property type="protein sequence ID" value="KWX22834"/>
        <property type="gene ID" value="AFM11_18035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.963"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022183">
        <property type="entry name" value="DUF3710"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12502">
        <property type="entry name" value="DUF3710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="255" mass="26874" checksum="FB7E0825BFDFB23B" modified="2016-06-08" version="1">MAFGKRKSNETTSDQGSDTPGNERIEPAVTDETDEDFDGPFDIEDFDDAAVAAQGRLDLGSVLIPMPDGGQVQVELNEAGAPSAVWVVTPNGRFTIAAYAAPKSAGLWREVAGELADSLRKDAASVAIQDGPWGREVVGAGNGGVVRFIGVDGYRWMVRCVVNGSPETIDALAEEARESLADTVIRRGDTPMPVRTPLQVQLPEPMAAQLRAAAQAAAQQGQQQAPPQEQPPAEPAARRSAQGSAMQQLRTITGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKV5</accession>
    <name>A0A132PKV5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_16545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850661.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22985">
        <property type="protein sequence ID" value="KWX22985"/>
        <property type="gene ID" value="AFM11_16545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.658"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="242" mass="26608" checksum="30B4C2807A7E7C79" modified="2016-06-08" version="1">MTTPSSFAAPGGKPPTATPPETVTEFVVEQLRDRIVLGQIQPGQKLSVYSLAEEFGVSRVPLREAVRQLEAECLVDNLPRRGTVVRPLNIADITDAYQIFERIEVIAAQRAATGGDASIAKEMRYWLDTMSALTEQGVPEASEQMLHAHRAFHFAMFRGGGEGVLQRHLRMLWNTCERYVIKSHTPERRVAAAREHDEIARQIEARDPDAVAEALAVHIHASMAATMASLRAMGIAESATPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PL15</accession>
    <name>A0A132PL15_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01440"/>
    <dbReference type="EnsemblBacteria" id="KWX23040">
        <property type="protein sequence ID" value="KWX23040"/>
        <property type="gene ID" value="AFM11_16870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.727"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="285" mass="29817" checksum="27AA23FE610A1C07" modified="2016-06-08" version="1">MGRVTYPPRGDQPWNRPGSAPSPFDDATIQFARSALPSPEPPAPPKRRGLKILVSAAVVLVLVVAGLGAAEWYARDRAKSIVAATLQCLMGDTSTVQLASMPPFLWQHFTGDYTVIDIQTAGKQIREAKGMRFDIAIRNLRLEDGPGSAGTMGSLDADVTWPADGIKESIQSAIPVLGQLVTDVTSNPDDGTLELNSVLASVTVKPEVSAKGGLALQIVDATGPGMGAISDLQPMLDDFLASQTDNFPLGVHADSVAVEKNGVVAHFSTENAALPAGGEDDCFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLD4</accession>
    <name>A0A132PLD4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tellurium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_17390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23161">
        <property type="protein sequence ID" value="KWX23161"/>
        <property type="gene ID" value="AFM11_17390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.832"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2510" evidence="2">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="300" mass="31701" checksum="33F615BA2994C9DC" modified="2016-06-08" version="1">MNGPRPGSWLPDPEGRYEYRWWDGQAWTDQVSHQGQVGRAPLGGPPPGSGTPASPAASEQRQHQPQHQAQPQPQGGDGFAGITGDLIDGRFSEKESAAIANQNDRMLRVRLGEPFMARQGSMVAYQGNVDFAFEGGGASKFLKKALTGEGLPLMRCQGQGDVFLADQANYVHLLHLTNSGLSISGKNVLAFSSSLDWNIERVKGGSIATGGLFNTTLRGSGWVALTTDGPPVVLNAGEAPTFADTNAVVAWSSHLQTQLKTSFKAGALIGRGSGEALQVAFHGNGFVIVQPSEGLTIPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLD5</accession>
    <name>A0A132PLD5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Citrate (Pro-3S)-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_17065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851027.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01635"/>
    <dbReference type="EnsemblBacteria" id="KWX23156">
        <property type="protein sequence ID" value="KWX23156"/>
        <property type="gene ID" value="AFM11_17065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.766"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="9"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX23156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="318" mass="34177" checksum="4BD2AB5219A15E13" modified="2016-06-08" version="1">MDNTYRPRRTCLSVPGSSAKMIEKAKTLPADEVFLDLEDAVAPDAKAQARTQVAVALAEDGWAGQLRGVRVNDWTTPWTYSDVIEVVSTAGAALDLIVLPKVTDVAHVHALDLLLSQLETTHGLPVGRIGIEAQIENAQGLTNVDAIAAGPRVQALVLGPADMMASLNMRTLVVGEQPDGYDVGDAHHHVLMRILIAARTHGINAIDGPYLKVRDTDAFRRVAGRSAALGYDGKWVLHPDQIEAGNEIFSPRQADYDHAELILDAYEWHTSQAGGARGAVMLGDEMIDEASRKMALVIAGKGRAAGMSRQAEPFRPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLI3</accession>
    <name>A0A132PLI3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01475"/>
    <dbReference type="EnsemblBacteria" id="KWX23047">
        <property type="protein sequence ID" value="KWX23047"/>
        <property type="gene ID" value="AFM11_16905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.734"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043796">
        <property type="entry name" value="ESX-1_EspA/EspE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18879">
        <property type="entry name" value="EspA_EspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EspA_EspE" evidence="2">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="526" mass="56206" checksum="E4D7E4DD200473CE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLX1</accession>
    <name>A0A132PLX1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin biosynthesis protein CobW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850485.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16760"/>
    <dbReference type="EnsemblBacteria" id="KWX23339">
        <property type="protein sequence ID" value="KWX23339"/>
        <property type="gene ID" value="AFM11_16155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7356"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="256"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="378" mass="41210" checksum="76AB26C89B10F53E" modified="2016-06-08" version="1">MPDLLPVTVLSGFLGAGKTTLLNHILANRDGKRVAVIVNDMSEVNIDAALVAGQGHLDRTEEKLVELTNGCICCTLREDLVEAVSALARQNRFDQLVIESTGISEPMPVAATFSWEFEDGFSLGALARLDTLVTVVDASTFLTELARGEALAEREMTAGPGDARSVADLLVDQVEFADVILLNKTDLVTAERLGAVEAVVRRLNPTARLLHTDHGVVGLDEVLDTGRFDPIAAAEAPGWDEEIAVGHTPETEEYGIGSMTFRADRPFHPHRLAQVLDNVRGLLRSKGFCWIATRPSIAAIWSQAGPNLVIEPAQFWSSTEFEPSQEIVFIGIRIDRDRLDAQLRSALLTDAELAAGEQAWLRYPDPLPAWNVTHSHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM26</accession>
    <name>A0A132PM26_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850274.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16230"/>
    <dbReference type="EnsemblBacteria" id="KWX23237">
        <property type="protein sequence ID" value="KWX23237"/>
        <property type="gene ID" value="AFM11_15555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7227"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="416" mass="41806" checksum="F84DB301D1E9747C" modified="2016-06-08" version="1">MTDGGGPPATGPITRSSVARVGVATAITAICGYAVLYLAARNLEPEGFSVFGVFWGAFGLVTGAANGLLQEATREVRSARHIDLTTSPRTHPMRIAAMVGVVSALVIAGSSPLWGAHVFAESQALSVALLSVGLAGFCLHATLLGMLAGVNRWTEYGALMVTDAAIRVAVAAATFVLGWGLVGFLWATVAGAASWLIMLIASPAARMAAQLVTAGGTTTFLRGAAHSIAAAGASAILVMGFPVLLKATSADLGAAGGVVILAVTLTRAPLLVPLTAMQGNLIAHFVDQRSTRLRALVAPAAVVAALGAVGVVGAGLVGPWLLRVGFGDEYRADGALLAWLTAAAVAIAMLTLTGAAAVAAALHRAYALGWVIATVTAVGLLLLPLGLETRTVVALLCGPLVGIAVHLGALARLSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM50</accession>
    <name>A0A132PM50_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="4">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_14070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849701.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09410"/>
    <dbReference type="EnsemblBacteria" id="KWX23416">
        <property type="protein sequence ID" value="KWX23416"/>
        <property type="gene ID" value="AFM11_14070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6918"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008746">
        <property type="term" value="F:NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000203">
        <property type="entry name" value="NADP_transhydrogenase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_N" evidence="13">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="12">
        <location>
            <begin position="146"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX23416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="511" mass="52464" checksum="A156544CAAC4F2DA" modified="2016-06-08" version="1">MIIGIPRESLPGETRVAATPQTVGQLIKLGYTVVVESGAGAASSFADGAYVDAGADIGTSDQTWASDVVLKVNAPDDSEIKSLRDGATLVGLISPALKPELVEKLSTRPITVLAMDAVPRISRAQSLDVLSSMANIAGYRAVVEAAHTFGRFFTGQVTAAGKVPPAKVLVVGAGVAGLAAIGAAGSLGAIVKATDPRPEVADQVASLGGEYVSVDPAAAEVSATGYAKEMGEDYKAREAQLYAELAKDVDIIITTALIPGKPAPRIITAEMVASMKPGSVIVDMAAANGGNVEGTVKDQAIVTDNGVTIIGYTDLAGRLPAQASQLYGTNLVNLLKLLTPEKDGQLTLDFDDVVQRSVTVVRDGQTTWPPPPVQVSAAPAAQPAAAAPAVKEEKPPMSTGRRLGITFAVAAAIFALIAISPAALQVHLTVFALAIVIGYYVIGNVHHALHTPLMSVTNAISGIIVVGALLQIGHGDIAITSLAFVAILLASINVFGGFAVTRRMLAMFSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMH3</accession>
    <name>A0A132PMH3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_14815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849957.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18085"/>
    <dbReference type="EnsemblBacteria" id="KWX23536">
        <property type="protein sequence ID" value="KWX23536"/>
        <property type="gene ID" value="AFM11_14815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7074"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="110" mass="11680" checksum="4A6EA8022E40DF18" modified="2016-06-08" version="1">MSQDSATVAVTDDSFSADVLTSSKPVLVDFWATWCGPCKMIAPVLEEIASEKADQLTVAKIDVDANPATARDFQVVSIPTMILFKDGAPVKRIVGAKGKAALLRELSDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMK4</accession>
    <name>A0A132PMK4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14130</name>
        <name evidence="2" type="ORF">AWC31_09270</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849724.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23427">
        <property type="protein sequence ID" value="KWX23427"/>
        <property type="gene ID" value="AFM11_14130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09136">
        <property type="protein sequence ID" value="ORX09136"/>
        <property type="gene ID" value="AWC31_09270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX09136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="102" mass="10717" checksum="2566EFC27F21477F" modified="2016-06-08" version="1">MRRVDEPAEARRADAFAALAGDERLEGDRDDVDREVDRADADLVDVPDDPDDALPSSVCPSRARSLSWCTRSAAPPTVSNTGHSMSPAVPTAAIVTAAAAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMQ4</accession>
    <name>A0A132PMQ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Twin-arginine translocation pathway</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850053.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17720"/>
    <dbReference type="EnsemblBacteria" id="KWX23583">
        <property type="protein sequence ID" value="KWX23583"/>
        <property type="gene ID" value="AFM11_15125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7137"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453465" evidence="1">
        <location>
            <begin position="32"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="252" mass="26498" checksum="3E79D84DD6B758E3" modified="2016-06-08" version="1">MQVSRRDALRYATALAGLGVAAGIGAPAASAAAPTLIDFAMRQIPAQDIRAAGHAGVINYVSTSRPGSSFGAKPITLPYARELTAAGLIIVSNYQYGKPGGTAPSDFTRGYAGGVADARTAWQLHTAAGGGRSAPIFFSVDDDIDQNTWNNVALPWFRGINSVIGVQRTGIYAGIRPCQWAIADGVIGRSSTPGRAWVWQTRSWSGGQIHPAAVLYQRIIDTASNPGPVVGGIRVDVNDVLAQDCGQWNKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN41</accession>
    <name>A0A132PN41_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849334.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03620"/>
    <dbReference type="EnsemblBacteria" id="KWX23756">
        <property type="protein sequence ID" value="KWX23756"/>
        <property type="gene ID" value="AFM11_13335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6761"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="307" mass="33209" checksum="C04479640801FF6F" modified="2016-06-08" version="1">MTKWTTASIPDQTGRIAVVTGANTGLGLETAKALAAKGAHVVLAVRNLDKGKAAIDWIARTVSESDLELQQLDLGSLESVRTAAAEIKDKHDRIDLLINNAGVMTPPKQTTADGFELQFGTNHLGHFALTGLLLDRLLPVTGSRIVTVSSTGHRFAPGIRFDDLQWERSYNRLQAYGQSKLANLLFTYELQRRLTGHQTTALAAHPGGSDTELARHLPRAFQVALPAARVLFQDAAMGALPTLRAATDPGALGGQYYGPDGFAEQRGYPKLVLSNQRSYDLDLQRRLWTVSEELTGVTFPVLQGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN78</accession>
    <name>A0A132PN78_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_13555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849429.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03800"/>
    <dbReference type="EnsemblBacteria" id="KWX23791">
        <property type="protein sequence ID" value="KWX23791"/>
        <property type="gene ID" value="AFM11_13555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6806"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="284" mass="29642" checksum="F0C54861A9584DA6" modified="2016-06-08" version="1">MPTLLQLKSFLAVVDDGGFTAAGRRLNLSQPAVSRAVASLENELGLPLLRRHRDGVSLTAAGDRAVVHARHAVQHMEAMRLEVAALAGELTGTLRVASLPFATGTAVAPWLRVFRDAHPRVTVHLLEGSEPEIRSWLDRGAADVGVVSLPAPEFETALLGVNEMVAVLPAGHRLAGLDAITYADLAGEPFIRSTGGCSAVFTPVAEKVGVALGADFEAHEMTAVIDMVRSGLGLSILPELPGPVPGIVTRPLVPATTRTLALAAPATAGPPARAFLRQVAARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNJ9</accession>
    <name>A0A132PNJ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848929.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02765"/>
    <dbReference type="EnsemblBacteria" id="KWX23622">
        <property type="protein sequence ID" value="KWX23622"/>
        <property type="gene ID" value="AFM11_12505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6591"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="127" mass="14099" checksum="C750BF98ADCB8800" modified="2016-06-08" version="1">MEILASRMLIRPVDYPKSLEFYRDGIGLAIAREYGAGTVFYAGQSLIEIAGHHSPTESGSFPGALWLQVRDVYATQAELESRGVPITRAATQEPWGLHEMHVIDPDGVTLIFVQVPATHPLRRDVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNK0</accession>
    <name>A0A132PNK0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849537.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23844">
        <property type="protein sequence ID" value="KWX23844"/>
        <property type="gene ID" value="AFM11_13880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6872"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="157" mass="17370" checksum="C40EDACAB95BF8E4" modified="2016-06-08" version="1">MNTDEYLYFLDRAFGGMLAALTELGDQRANEAPPLTGANSPWAITYHCTQVAEYWIGHLIGGRSSDRDRAAEFTARGSIDELTRTVEEVKDQLRRDLSDFDPSAPLRNTPPADYEGPSRALTPIGVLLHVLEELAQHHGQVELTRDVLVRPTVGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNY7</accession>
    <name>A0A132PNY7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30265"/>
    <dbReference type="EnsemblBacteria" id="KWX24035">
        <property type="protein sequence ID" value="KWX24035"/>
        <property type="gene ID" value="AFM11_11765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6431"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="548" mass="55706" checksum="B43E81A64B9E87D4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPB0</accession>
    <name>A0A132PPB0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_11865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30185"/>
    <dbReference type="EnsemblBacteria" id="KWX24178">
        <property type="protein sequence ID" value="KWX24178"/>
        <property type="gene ID" value="AFM11_11865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6452"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="12"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="474" mass="50106" checksum="17EE859D34E98E2B" modified="2016-06-08" version="1">MEADWSLDGDHSHQIEVVSPHTEQPIARVAASLPADVDAAVAAARAAVDRGPWPRLPPDERIAALRRLADVYSQRREQMAQLISAEIGAPISFAKRAQVGLPTMMMSAFCDVAETYPWHESRPGFFGADVRIRREPVGVVAAIVPWNMPQFLIVTKLVPALIAGCAVVLKPAPESPLDALLLAEMIEQIGLPEGVVTVVPGDAAVGAHLASHPGVDKVSFTGSSSAGRAVATACAANLTKVSLELGGKSAAIVLDDADPEMVAAGVRSASLSNSGQICNALTRIVVPAAREEEFVDALAARMSALKVGDPADPATELGPLVSRRQQQRVRDYIELGRREGARLVVGGTDLPAGLDTGWYVQPTLFAAADNSMRIAREEIFGPVLTVIPYEDERDAIAIANDSDYGLAGSVWTADTDRGVRIAEQVRTGTFGVNQGYTMDPFAPFGGVKDSGYGRELGREGLDGYVETKSIAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPH6</accession>
    <name>A0A132PPH6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein</fullName>
            <ecNumber evidence="3">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848118.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30665"/>
    <dbReference type="EnsemblBacteria" id="KWX23942">
        <property type="protein sequence ID" value="KWX23942"/>
        <property type="gene ID" value="AFM11_11230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6323"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="281"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="281"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="386" mass="41321" checksum="43551FF252215C3A" modified="2016-06-08" version="1">MSEPDWAPLTGFRVAVTSSRRADELSALLRRRGATVTSAAAITMVPLPDDDELRSHTESLIDLPPDIVVATTGIGFRGWIAAADGWGLANELTDALGKARIVSRGPKATGALRAAGLPEEWSPESESSREVVRYLVEHGVVGQRIAVQLHGATDEWDPFPEFLDELREAGAEVVPIRVYRWHPAPADGDFDQLVAGIAERRFDAVSFTSAPAVASVLMRATEMGIADRVVSALRTDVHAMCVGPVTARPLVRLGVPTSAPERMRLGALARHITDELPLLQSRTVRVAGHVLEIRGTCVLVDGVVKSLSPAAMATIRALAHRPGAVVSRFDLLGALPGSGTDTHAVETAVLRLRTALGDKNIVSTVVKRGYRLAVDDSEMKDMARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPH9</accession>
    <name>A0A132PPH9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Resuscitation-promoting factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_09645</name>
        <name evidence="5" type="ORF">AWC31_05580</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847219.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05580"/>
    <dbReference type="EnsemblBacteria" id="KWX24248">
        <property type="protein sequence ID" value="KWX24248"/>
        <property type="gene ID" value="AFM11_09645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09699">
        <property type="protein sequence ID" value="ORX09699"/>
        <property type="gene ID" value="AWC31_05580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5967"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453178" evidence="2">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylas" evidence="3">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX09699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="107" mass="10984" checksum="6CE17CBD857BEDC6" modified="2016-06-08" version="1">MKNIRKTFGLGIIAGALAVAPVALGAGTANADSVNWDAVAACESGGNWSINTGNGYYGGLQFNLGTWRSHGGSGMPHQASRAEQIRVAEKVLNTQGIGAWPVCGQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPN3</accession>
    <name>A0A132PPN3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_09670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847233.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05555"/>
    <dbReference type="EnsemblBacteria" id="KWX24253">
        <property type="protein sequence ID" value="KWX24253"/>
        <property type="gene ID" value="AFM11_09670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5972"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="334" mass="36393" checksum="977F3A9AE275BDE5" modified="2016-06-08" version="1">MAHRYKVREIAQQCGLSEATVDRVLNNRPGVRENTRDEVRQAIADLDKQRAQLRLNGRRYLIDVVMQTPQRFSDAFRAAVEAELPAFAPAMLRARFHLWESGSTAQMVDTLTRIRSSHGVVLKAADEPEVAEAVDHLVASGVPVVTYATDIPTSSRCAYVGIDNHGAGVTAAYLIEQWLGPAPSGVLITVSRTVFRGEGEREVGFRSGLRASGRPVVEVTDSDGIDATNEGLVLDALQRHPSVEAVYSPGGGNLATVSAFDKLGRTCKVFVAHDLDADNRRLLRDGRISVVLHNDLRADARLAMRLILQQHGALPAETVRPAPIQVITPYNLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPZ4</accession>
    <name>A0A132PPZ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_12200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848645.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09775"/>
    <dbReference type="EnsemblBacteria" id="KWX24112">
        <property type="protein sequence ID" value="KWX24112"/>
        <property type="gene ID" value="AFM11_12200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6519"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M13_N" evidence="9">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13" evidence="8">
        <location>
            <begin position="450"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX24112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="658" mass="73358" checksum="F28025822CDA7B16" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ02</accession>
    <name>A0A132PQ02_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_12260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848672.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09720"/>
    <dbReference type="EnsemblBacteria" id="KWX24122">
        <property type="protein sequence ID" value="KWX24122"/>
        <property type="gene ID" value="AFM11_12260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6531"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027595">
        <property type="entry name" value="CHP04338"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04338">
        <property type="entry name" value="HEXXH_Rv0185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="157" mass="17124" checksum="46449A87EFFFFB33" modified="2016-06-08" version="1">MTAKDAQRARVYAAEQFVRTMFDRAAQHSSRAIDFFGTSLTLPPEARFASVESVQRYVDDVLARVGAAPVTVRARRGTTAAHYELVDGAAVIAVPERDTTWALRELVVLHELAHHLCSEGPPHGPAFVATYCELCATVMGPEVGLVLRMVYAKEGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ04</accession>
    <name>A0A132PQ04_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prokaryotic cytochrome C oxidase subunit IV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_10470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847637.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18905"/>
    <dbReference type="EnsemblBacteria" id="KWX24383">
        <property type="protein sequence ID" value="KWX24383"/>
        <property type="gene ID" value="AFM11_10470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6134"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="85" mass="9366" checksum="5A22438E863597C7" modified="2016-06-08" version="1">MNVIRRITVVWATLCVVTVVSWWLGHGAAVASVPITVSVVALAAIKCRLIIREFMEVRTAPAWLRFGTDAWLAALSATVLAIYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ44</accession>
    <name>A0A132PQ44_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_10780</name>
        <name evidence="9" type="ORF">AWC31_19295</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX16984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847795.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19295"/>
    <dbReference type="EnsemblBacteria" id="KWX24433">
        <property type="protein sequence ID" value="KWX24433"/>
        <property type="gene ID" value="AFM11_10780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16984">
        <property type="protein sequence ID" value="ORX16984"/>
        <property type="gene ID" value="AWC31_19295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6195"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="47"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX16984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="445" mass="51420" checksum="CF7798C759B34712" modified="2016-06-08" version="1">MAFFPKPAAGSWTENWPELGTGPVNYEDSIDPEHWKLEQQAIFRKTWLQMGRVELIPKKGSYITRELPSVGPGTSIIIVNDGDQIRAFYNLCRHRGNKLVWNDYPGEEVSGSCRQFVCKYHAWRYNLKGDLTFIQQEQEFFDVDKADYPLKPVRCEVWEGFIFVNFDDDAVSLEEYLGEFGQGLKGYPFHEMTEHYSYRSEIKANWKLFIDAFVEFYHAPILHMKQAEKEEAEKLAKFGFEALHYDIKGDHSMISSWGGMSPPKDLKMVKPIERILHSGLFGPWDRPDIKGILPDELPPAINPGRHKTWGQDSFEFFPNFTLLFWVPGWYLTYNYWPTGVDTHIFEADLYFVPPKNLRERLSQELAAVTFKEYAFQDANTLEATQTQIGTRAVLDFPLCDQEILLRHLHHTAHKYVDRYKESLANGNGSANGAAHTKTTKDPANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ74</accession>
    <name>A0A132PQ74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24357">
        <property type="protein sequence ID" value="KWX24357"/>
        <property type="gene ID" value="AFM11_10315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6100"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="557" mass="58007" checksum="7F2C0DB7A5D835C3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ93</accession>
    <name>A0A132PQ93_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847890.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24465">
        <property type="protein sequence ID" value="KWX24465"/>
        <property type="gene ID" value="AFM11_10965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6234"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="279" mass="31543" checksum="D37B95DF68C6E214" modified="2016-06-08" version="1">MDKQALAEFLRRRREMLRPGDVGLTDGPRRRTHGLRREEVAHLAGMSTDYYTRLEQQRAPQPSLQIAAALARALRLTQDETDHLFLLVGHNAPARFQRSEHVSPALMRVLDRLYDSAALVQTDLVETLAMNPLAIALLGDQTRHTGLAHSGVYRWFMDPAERLRFPVEAHERHGRAQAARLRAALTSGSDTARAAAIRDELQEHSPEFTRMWDLQQVAHRYDDTTTILHPELGRIDVDGQVLFTDNRAQTLVVLTARHGTESHTKLELLSVIGHQKLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQD2</accession>
    <name>A0A132PQD2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_07595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846024.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22095"/>
    <dbReference type="EnsemblBacteria" id="KWX24541">
        <property type="protein sequence ID" value="KWX24541"/>
        <property type="gene ID" value="AFM11_07595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5367"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="243" mass="27262" checksum="5BE9E13967CC19D4" modified="2016-06-08" version="1">MKLPTFSPSRGGSRDTVARPSASGLDEHMEASQRAQRQADKWLISGSLLIGTAALGIFGLPLFLRGVWLLRKAQRDGLSVRPMLVTLIGYLVIIDAAINTVGWALDLVANHTILARILLNGWGAMFDAGYFWHYNELWLGGSSGPGEKAMEVGMILTVFTMRIAAAIGFLQMKRWGHQWMIITCWMGIVIWCLYVFNMTMFADVRFAGVVLPVVGWWLYDIFYITPFLAIPYLHSVNREIFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQY2</accession>
    <name>A0A132PQY2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetoin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846415.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00230"/>
    <dbReference type="EnsemblBacteria" id="KWX24674">
        <property type="protein sequence ID" value="KWX24674"/>
        <property type="gene ID" value="AFM11_08340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5519"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="283" mass="30268" checksum="97BDA74F2D7A9874" modified="2016-06-08" version="1">MSKRRTISGRTIVISGAASGIGRALAQRLSAHSCPVAISDVDEGGLKETEAGLRGPVLARVLDVRDADAQRDFAAEVADWAPQPIGAVFNNAGVAVSSSVLDSVPEDDNWLWDINFHGVVNGTRAFLPVLVKQDEGAIVNTSSVFGLVGMPNQSAYCSAKFAVRGFTDSLRQELRGTGVTAINVHPGGINTNIVRNARFRRDPEGRGRSHEQMADEFAAITMTQPGKAAEIIHRGVEAGKARILVGPDAYVFDALARIAPTRYYDVMSMAMTRLRRRAAAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR07</accession>
    <name>A0A132PR07_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_09865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847330.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24482">
        <property type="protein sequence ID" value="KWX24482"/>
        <property type="gene ID" value="AFM11_09865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6011"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX24482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="213" mass="23078" checksum="C2167438BB4D387B" modified="2016-06-08" version="1">MAPKLNRDVIARTGLDLLGEHGLDGLSMRILATALGVQAPTLYWHVKNKRELLDMMADVIAGEIGERLRPRRPDESAHDWLAEVARAIRAALLAYRDGARVFVGSATPSARPANELALRELQAAGFDLDAAARAVLTLLHYVTGSTIEEQARRGLDYDDNPYRNAYLLNAKHFPLGAQVRDVLFNPDADASFEAGLTVVLAGISATLGPRADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR54</accession>
    <name>A0A132PR54_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_07545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845997.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22045"/>
    <dbReference type="EnsemblBacteria" id="KWX24532">
        <property type="protein sequence ID" value="KWX24532"/>
        <property type="gene ID" value="AFM11_07545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5357"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="616" mass="68958" checksum="8415A3BD3DCF8A7B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRF0</accession>
    <name>A0A132PRF0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFM11_05535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845016.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12910"/>
    <dbReference type="EnsemblBacteria" id="KWX24906">
        <property type="protein sequence ID" value="KWX24906"/>
        <property type="gene ID" value="AFM11_05535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4297"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="11">
        <location>
            <begin position="49"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Fumerase_C" evidence="12">
        <location>
            <begin position="331"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KWX24906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="549" mass="59184" checksum="1F56EAA6A5922FB8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRL2</accession>
    <name>A0A132PRL2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05525</name>
        <name evidence="3" type="ORF">AWC31_12900</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845012.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12900"/>
    <dbReference type="EnsemblBacteria" id="KWX24904">
        <property type="protein sequence ID" value="KWX24904"/>
        <property type="gene ID" value="AFM11_05525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18852">
        <property type="protein sequence ID" value="ORX18852"/>
        <property type="gene ID" value="AWC31_12900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4295"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016793">
        <property type="entry name" value="UCP021591"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021591">
        <property type="entry name" value="UCP021591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453230" evidence="1">
        <location>
            <begin position="32"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="144" mass="15464" checksum="CE821525E8684191" modified="2016-06-08" version="1">MTNMRKVTTTVGAAVVLAAAGMAVSNATSYAEPEAGGHQVRYTLTTGAPYDFDLYYLATQPPSKEAYDADPYAFLQKAEVNVVPEAPWVFETTLADPQWAIFTVASTTHGGRGAPNAHCEIAVDGQVAVQNDHPYSPRCQLGQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS04</accession>
    <name>A0A132PS04_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845460.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28835"/>
    <dbReference type="EnsemblBacteria" id="KWX25126">
        <property type="protein sequence ID" value="KWX25126"/>
        <property type="gene ID" value="AFM11_06815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4562"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="131" mass="13861" checksum="285DEF8518DE789D" modified="2016-06-08" version="1">MFSTGAVRYLVADVDRAVGFYTQHLGFELLRQPAPAFAAIASGSLTLWLSGPGSSGARPLTDGQAQTPGGFNRIVLEVEDLDSAIGELHGRGIEFRNGLEVGPGGRQIQLSDPDGNPIELFEPAKVRTPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS16</accession>
    <name>A0A132PS16_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_06830</name>
        <name evidence="3" type="ORF">AWC31_28820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000017">
        <property type="protein sequence ID" value="ORX13795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845467.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28820"/>
    <dbReference type="EnsemblBacteria" id="KWX25129">
        <property type="protein sequence ID" value="KWX25129"/>
        <property type="gene ID" value="AFM11_06830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13795">
        <property type="protein sequence ID" value="ORX13795"/>
        <property type="gene ID" value="AWC31_28820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4565"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="230" mass="25400" checksum="3A525F8160C78C50" modified="2016-06-08" version="1">MPYGNTAHEVLAVVFQVRDLSSRQPTLNVLLWQRALEPERGKWSLPGGRLGDDEDLTSSVRRQLAEKVDLRELAHLEQLAVFSDPARIPGVRTIASTFLGLVPSPATPALPSDTRWHNVNDLPPMAFDHAPMVEHARTRLAAKLSYTNIGFALAPKEFAISTLRDIYSAALGYQVDATNLQRVLERRNVITRTGTTARSGRSGGRPAALYGFTESRYRVTDEFAALRPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS92</accession>
    <name>A0A132PS92_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_07200</name>
        <name evidence="7" type="ORF">AWC31_17515</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000007">
        <property type="protein sequence ID" value="ORX17495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845664.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17515"/>
    <dbReference type="EnsemblBacteria" id="KWX25193">
        <property type="protein sequence ID" value="KWX25193"/>
        <property type="gene ID" value="AFM11_07200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17495">
        <property type="protein sequence ID" value="ORX17495"/>
        <property type="gene ID" value="AWC31_17515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4640"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX17495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="295" mass="32380" checksum="D038A6117FE8381D" modified="2016-06-08" version="1">MASKLSFSRPELLPGQKRWSIGAVAADVGLVFWFVFSLFPIFWMLMLALKNAEQQTTTYFSFSPTWSNFATVLSDKGTQMTSVDFKASLLTSLLNCGGAVIVSLVIGIPAAYAAGRWQYKGSNDLMFQMLSFRFAPELMVIVPLFVIYNQIGLFDTKVGMIWVLQLVTMPLVVWILRSYFQDLPEDLEQAALLDGYTRRRAFVMVALPIVRPGIAAAALLAFIFAWNNYVFPLILADSNAGTVTVAITKFLGGGGQAYYNLTAAAAIIAALPPLILALTIQRYLVRGLSFGAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSB5</accession>
    <name>A0A132PSB5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_05405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845774.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12780"/>
    <dbReference type="EnsemblBacteria" id="KWX25229">
        <property type="protein sequence ID" value="KWX25229"/>
        <property type="gene ID" value="AFM11_05405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4270"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009448">
        <property type="term" value="P:gamma-aminobutyric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004632">
        <property type="entry name" value="4NH2But_aminotransferase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00700">
        <property type="entry name" value="GABAtrnsam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="446" mass="47371" checksum="B4CF13EED7C299F2" modified="2016-06-08" version="1">MSHLEQSRHLATAIPGPNSQALIDRKTTAVARGVGTTMPVYAARAGGGIVEDVDGNRLIDLGSGIAVTTIGNASPRVVEAVRAQAGDFTHTCFMVTPYEEYVAVCEHLNRLTPVRGEKRSALFNSGSEAVENAVKIARSHTRKPAVVAFDHAYHGRTNLTMALTAKVMPYKHGFGPFAPEVYRAPLSYPFRDAEFGKELATDGELAARRAISVIDKQIGADNLAAVIIEPIQGEGGFIVPADGFLPALLDWCRRNDVVFIADEVQTGFARTGAMFACEHEGIDPDLIVTAKGIADGLPLSAVTGRAEIMDSPHVSGLGGTYGGNPLACAAALATIETIESDGLVARARQIEQLMKDRLGRLQAEDDRIGDVRGRGAMIAVELVKPGTTEPDAELTKALCTGAHTAGVIVLSCGTYGNVLRFLPPLTISDELLIEGLDVLELILRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSG8</accession>
    <name>A0A132PSG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25301">
        <property type="protein sequence ID" value="KWX25301"/>
        <property type="gene ID" value="AFM11_03145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="96" mass="10566" checksum="76BE2F52BCECE901" modified="2016-06-08" version="1">MERARRCSHGFRPSHRGTVSVPTSAPMSPSSSRTGSPPWPWRRPSPDTDPRRIASGPGHSRQHHLRLTLNSRIVIPKPSSPTACPTVSSVRCQHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSG9</accession>
    <name>A0A132PSG9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFM11_06020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845815.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29640"/>
    <dbReference type="EnsemblBacteria" id="KWX25245">
        <property type="protein sequence ID" value="KWX25245"/>
        <property type="gene ID" value="AFM11_06020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4395"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="262"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX25245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="327" mass="34138" checksum="3E0EDC44249CE28C" modified="2016-06-08" version="1">MRLAIEQAERVKGSTYPNPPVGAVILDPDGQVAGIGGTQPAGGPHAEVMALRDAGHRAAGGTAVVTLEPCNHHGRTPPCVDALVTAGISRVVYAVGDPNPVAAGGAARMADAGIEVTAGLLADEVSRGPLREWLHKQRTGLPHVTWKFATSVDGRSAAADGSSQWITSEAARADVHRRRAVAEAIVVGTGTVFFDDPALTARLPDGTLADRQPLRVVVGEREVSSDSKVLNDDSRTMVIRTHDPHEVIRSLADRTDVLVEGGPTLAGAFLRAGVVNRILAYVAPILLGGPITAVDDVGVLSIAHAQRWRFDGIEAIGPDVLLSLVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSV5</accession>
    <name>A0A132PSV5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_03995</name>
        <name evidence="9" type="ORF">AWC31_21160</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844312.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21160"/>
    <dbReference type="EnsemblBacteria" id="KWX25431">
        <property type="protein sequence ID" value="KWX25431"/>
        <property type="gene ID" value="AFM11_03995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16543">
        <property type="protein sequence ID" value="ORX16543"/>
        <property type="gene ID" value="AWC31_21160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2677"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01110">
        <property type="entry name" value="HTH_SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010211">
        <property type="entry name" value="Redox-sen_tscrpt-act_SoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30204:SF0">
        <property type="entry name" value="PTHR30204:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01950">
        <property type="entry name" value="SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX16543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="143" mass="16012" checksum="C088163F80294B79" modified="2016-06-08" version="1">MDMHELTPGEMAQRSGVAVSALHFYEREGLITSRRTSGNQRRYARETLRRVAFIRMSQRLGIPLARIREALATLPTDRVPTSKDWARLSAGWRQDLDDRILHLQRLRDNLTGCIGCGCLSLKTCLLTNPGDVLAEQGPGAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT03</accession>
    <name>A0A132PT03_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844383.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21025"/>
    <dbReference type="EnsemblBacteria" id="KWX25453">
        <property type="protein sequence ID" value="KWX25453"/>
        <property type="gene ID" value="AFM11_04130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2704"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="292" mass="31363" checksum="1D043A3BAEEB3BE9" modified="2016-06-08" version="1">MTEWTSADLPSFTGRSVVVTGANSGLGLITARELARVGAKVIVAVRNLDKGTAAAATMTGGTVEVRKLDLQDLASVHEFADTVETVDVLVNNAGIMAVPLSRTADGFESQIGTNHLGHFALTNLLLPKVSDRVVTVSSLMHWIGVISLRDLNWKSRPYSAWLAYGQSKLANLMFTSELQRRLSASGSQVRAVAAHPGYSATNLQGHTGSRFGSRMAEAGNRFMATEPEFGARQTLYAVSQDVPGDSFIGPRFGQFGPTQPVGRSPLAKRTETQKALWDLSEQLTGVSYPLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTD6</accession>
    <name>A0A132PTD6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_03215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843893.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21880"/>
    <dbReference type="EnsemblBacteria" id="KWX25312">
        <property type="protein sequence ID" value="KWX25312"/>
        <property type="gene ID" value="AFM11_03215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2518"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="340"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="490" mass="53740" checksum="4ACF5D3836F20478" modified="2016-06-08" version="1">MFEELDDAALAAGIEHETRAAAASDSRRLQMIAELIGRRVAEQDDELLHWACDYWDSAAGEVAAAMNVGHRAASREMLIAVALQERFPRVAALYAQGRLSSRLISTVTWRTRLIEDAETLQIMDAALVDRVVEWGPLSVEKLEQSIDALIERHDPEALRRTRTVARDRDVCFGKPDDATGTVSLYGRLLATDRAAFENRLAHMISGVCEDDPRTLGQRRSDAMGVLGAGGDRLKCQCGKSDCPAADVVDARAANTVVYVLAEPAALDAEPDPYLSGDDESNPIPRDEPPRPAKKPASAVIIGGGVVPTPLLAQLIACGAKVRELAQPCGEPEPRYRPSTGLAAFVRMRDMTCMFPGCDRPAVNCDIDHSVPYPAGATHPSNTKCLCRTHHLLKTFWDGWSDRQLPDGTVVWTTPSGRTYTKKPASRLFFPHWDTTTAALPPPRGRTVATDRGVMMPRRALTRAQREARQIKAERALNRAYLAERNKPPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTH1</accession>
    <name>A0A132PTH1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844783.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25631">
        <property type="protein sequence ID" value="KWX25631"/>
        <property type="gene ID" value="AFM11_05240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2933"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="576" mass="62437" checksum="AC1423FA6DF5B9D8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTP9</accession>
    <name>A0A132PTP9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844300.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25685">
        <property type="protein sequence ID" value="KWX25685"/>
        <property type="gene ID" value="AFM11_03975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2673"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453625" evidence="1">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="83" mass="8664" checksum="01CE9315A5504EFD" modified="2016-06-08" version="1">MYELAVAALTGSALSALTLGFPAETLAAPSGIGSAQDTVNELEQDGYRVVLYKMGPAPLDRCTVDSVRPGEAVTQTVYLTARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU04</accession>
    <name>A0A132PU04_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_00365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842205.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33480"/>
    <dbReference type="EnsemblBacteria" id="KWX25785">
        <property type="protein sequence ID" value="KWX25785"/>
        <property type="gene ID" value="AFM11_00365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.73"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="524" mass="54354" checksum="E11CFAAB1A42BEC9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU29</accession>
    <name>A0A132PU29_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">AFM11_00285</name>
        <name evidence="7" type="ORF">AWC31_33395</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842167.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33395"/>
    <dbReference type="EnsemblBacteria" id="KWX25774">
        <property type="protein sequence ID" value="KWX25774"/>
        <property type="gene ID" value="AFM11_00285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11585">
        <property type="protein sequence ID" value="ORX11585"/>
        <property type="gene ID" value="AWC31_33395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.58"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX11585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="77" mass="8790" checksum="F31CD14554A47947" modified="2016-06-08" version="1">MAVGTTPGELRELTDDELKDKLRESKEELFNLRFQMATGQLSNNRRLRTVRQEIARVYTVLRERELGLASGPVGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU79</accession>
    <name>A0A132PU79_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ethanolamine ammonia-lyase large subunit</fullName>
            <shortName evidence="1">EAL large subunit</shortName>
            <ecNumber evidence="1">4.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eutB</name>
        <name evidence="2" type="ORF">AFM11_01010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ethanolamine = acetaldehyde + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15313"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="EC" id="4.3.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
        <text evidence="1">Binds between the large and small subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine degradation; ethanolamine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EutB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.7" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842539.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34040"/>
    <dbReference type="EnsemblBacteria" id="KWX25901">
        <property type="protein sequence ID" value="KWX25901"/>
        <property type="gene ID" value="AFM11_01010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.208"/>
    <dbReference type="UniPathway" id="UPA00560"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008851">
        <property type="term" value="F:ethanolamine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00861">
        <property type="entry name" value="EutB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010628">
        <property type="entry name" value="EutB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044939">
        <property type="entry name" value="EutB_dom_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044941">
        <property type="entry name" value="EutB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39329">
        <property type="entry name" value="PTHR39329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06751">
        <property type="entry name" value="EutB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018788">
        <property type="entry name" value="EutB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="471" mass="50069" checksum="BFF5357E627D3411" modified="2016-06-08" version="1">MKYRQQVSGVTYTFDGLVEVMAKATPLRSGDQLAGCAAEHDGERAAAAWVLADLPLDTFLNEEVVPYDTDEVTRLIFDSHDRQAFSPVSHLTVGGFRDWLLETASHDHSAEQFAAVAPGLTPEMVAAVSKIMRNQDLIAVSAAAQVTAALRTTIGAPGTLATRLQPNHPTDDPRGIAAAVLDGLLLGCGDAVIGINPATDSPQATADLLYLLDSIRTRYDIPAQSCVLSHITTTIGLIEAGAPVDLVFQSIAGTEGANSAFGVNLQLLREGRDAARSLNRGTVGDNVMYLETGQGSALSSGAHLGVGGKPVDQQTLETRAYAVARDLQPLLVNTVVGFIGPEYLYDGKQIIRAGLEDHFCGKLLGLPMGVDVCYTNHAEADQNDMDTLLTLLAAAGVAFVITVPGADDVMLGYQSLSFHDVLVTRRTLGLRPAPEFEAWLRSVGMVDDTGRLTPFDLERSVLRSLTSAEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUK7</accession>
    <name>A0A132PUK7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosomal subunit interface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_01675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842871.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25995">
        <property type="protein sequence ID" value="KWX25995"/>
        <property type="gene ID" value="AFM11_01675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.345"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08881">
        <property type="entry name" value="RHO_alpha_C_NDO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043266">
        <property type="entry name" value="RHO_NdoB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="44"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX25995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="441" mass="49237" checksum="E6FF6D79A081BA81" modified="2016-06-08" version="1">MIVAVDADYLHSLVNWKEGKIGPEIFVSDEIYRLEQERIFGRSWLFLAHDSMIPNPHDFFATYMGGDPVLVTRQPDGSVKAFLNVCRHRGMRVCRAEEGNARSFMCTYHGWTYDSAGKLVGVPNLDDAYDNKLSLPDNGLVQVAQIASYKGLIFGNFDPDAPPLDEYLGALKFYIDGWVDHAEGGIEILPGAIKWTINANWKLAAEQFAGDTYHATTSHLSSLLAFGPGFDAKDGAHVSLREGHGESFLFERHTRFSDDPLGQYNENKRRIARERVGDRADMVANFNAFPNFAGLPGSANIRVWHPKGPTKFEIWSFTVVEKDAPEEAKRAQQISASFTEGAAGVVETDDGENWGMIGGVLEQGYQARKMEWNYEMGLGSERDNLQFPGEYHDSFFGEAGQRGFYRRWLDFMTAEAWPVIPPEERSVALPAVAMSDVAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUM2</accession>
    <name>A0A132PUM2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="5 16">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFM11_01985</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 16"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843022.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34765"/>
    <dbReference type="EnsemblBacteria" id="KWX26041">
        <property type="protein sequence ID" value="KWX26041"/>
        <property type="gene ID" value="AFM11_01985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.406"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 16" id="KW-0274">FAD</keyword>
    <keyword evidence="9 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0813">Transport</keyword>
    <keyword evidence="8 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="17">
        <location>
            <begin position="8"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="18">
        <location>
            <begin position="455"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="15">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KWX26041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="584" mass="64554" checksum="2784C1B60A4BB1A5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUM9</accession>
    <name>A0A132PUM9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enamine deaminase RidA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Endoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_02090</name>
        <name evidence="2" type="ORF">AWC31_34870</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843067.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34870"/>
    <dbReference type="EnsemblBacteria" id="KWX26058">
        <property type="protein sequence ID" value="KWX26058"/>
        <property type="gene ID" value="AFM11_02090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11835">
        <property type="protein sequence ID" value="ORX11835"/>
        <property type="gene ID" value="AWC31_34870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.428"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX26058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX11835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="145" mass="15953" checksum="21C260F1B2441FF6" modified="2016-06-08" version="1">MPDIAAPTHTRIRPFNTKDTYPEQNLDNDLCQAVVAGGVVYLRGQIGQDLETRESVGIGDVAAQTEKAMSNIAMLLDEAGSSLRDIVKVTVYLTDIRYRETVYRIMGRWLKGVYPVSTGLVVEALARPEWLVEIDATAVISEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUW8</accession>
    <name>A0A132PUW8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843292.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35275"/>
    <dbReference type="EnsemblBacteria" id="KWX26126">
        <property type="protein sequence ID" value="KWX26126"/>
        <property type="gene ID" value="AFM11_02495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.511"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025492">
        <property type="entry name" value="DUF4383"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14325">
        <property type="entry name" value="DUF4383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="165" mass="17073" checksum="12F4A339E4361371" modified="2016-06-08" version="1">MTTPNPRSPGRTTRATPVQVAALVVGATFLLVGILGFIPGITSDYGDMSFAGHHSHAMLLGVFAVSVLHNVVHLLFGVAGLLMARTAGAARAFLIGGGIIYAVLWLYGLVIDRDSAANFIPVNTADNWLHFGLALIMILLGVALGRQTASTTTHGLGTGAPGTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PVJ6</accession>
    <name>A0A132PVJ6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH:flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_02060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843052.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34840"/>
    <dbReference type="EnsemblBacteria" id="KWX26052">
        <property type="protein sequence ID" value="KWX26052"/>
        <property type="gene ID" value="AFM11_02060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.422"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02929">
        <property type="entry name" value="TMADH_HD_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037348">
        <property type="entry name" value="TMADH/HD_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="9"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="389"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX26052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="708" mass="77776" checksum="6D90A4592CAAB4C0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAS5</accession>
    <name>A0A132PAS5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000054">
        <property type="protein sequence ID" value="KWX19430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067860035.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29815"/>
    <dbReference type="EnsemblBacteria" id="KWX19430">
        <property type="protein sequence ID" value="KWX19430"/>
        <property type="gene ID" value="AFM11_35925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6262"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="30739" checksum="7F2BB0A2F8B762DD" modified="2016-06-08" version="1">MDNIRAKTIAITGAARGIGYATAKALLARGARVVIGDRDVALQESAVVELTKLGQVSGYPLDVTDRESFATFLDKARTDGGGHIDVLINNAGVMPVGPFLEQSEQSIRSNIEVNVYGVLTGCQLALPDMVKRRSGHIINIASLSGLIPLPGQVVYVGAKYAVVGLSTALADEMAPHGVDVSVIMPPFTNTDLIAGTKSGGAIKPVEPEEIAAAIVKTLNKPKTHVSVPPPLRFTAQAAQMLPPKGRRWLNKKLGLDNVFLEFDAAKRKSYEDRAQAALGVIDSDGKNSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB04</accession>
    <name>A0A132PB04_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureG</name>
        <name evidence="6" type="ORF">AFM11_35615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859847.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02635"/>
    <dbReference type="EnsemblBacteria" id="KWX19498">
        <property type="protein sequence ID" value="KWX19498"/>
        <property type="gene ID" value="AFM11_35615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5859"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="10"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="205" mass="21759" checksum="4F45E744C390C837" modified="2016-06-08" version="1">MTTALKAARIGIGGPVGSGKTALVEALLAGFALRGRSVSVITNDLVTVEDAERIRRSGLIDPRRVRAVEAGGCPHTVIREDPSLNMAAADALEAEFPDTEMILLESGGDNLASTFSRDLVDYWLFVIDVAGGDDIPRKRGPGVLRCDLLVINKVDLAPHVGVDLALMCKEADEVRCGRPVVAISARGGQGVDVVMDVLERDVLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB87</accession>
    <name>A0A132PB87_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Immunogenic protein MPT63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_35075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000041">
        <property type="protein sequence ID" value="KWX19564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859695.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19564">
        <property type="protein sequence ID" value="KWX19564"/>
        <property type="gene ID" value="AFM11_35075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5743"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015250">
        <property type="entry name" value="MPT63-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09167">
        <property type="entry name" value="DUF1942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007452992" evidence="2">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1942" evidence="3">
        <location>
            <begin position="33"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="189" mass="19520" checksum="BAA472BC72029F3D" modified="2016-06-08" version="1">MRIVRRVVVATAALLGMMLLGAPAAGAAQQCPHKLGSTQQLVDADGAVVQEWTLTDLRPSSDPAPGYPLAGRLWEATVSVRAVNGTVTPVIPGFEAMGTDHRSYPVLWQLASPAGIPAATLAEGATATGKVYFDVTGADPAAVIYTRGGARPAMMWCDMAAMAPMMAMPMDDCPCCGPDCACCAGKPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBF8</accession>
    <name>A0A132PBF8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859350.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19665">
        <property type="protein sequence ID" value="KWX19665"/>
        <property type="gene ID" value="AFM11_34585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5262"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="366" mass="40321" checksum="99C68FA41E1C6C88" modified="2016-06-08" version="1">MTVDMSLAARIRAYSAASTALAAHSDHTLRELVDAATPIGTGIGGQSALLEVVGTPVFVKRVPLTDLERQPEHVRSTANVFDMPPFCHYGVGLVGSPGFGAWRELAVHIMTTNWVLAAEYEGFPLMYHWRVLPGATPLPHELADIDRAVAYWDGEIQVRRRIEALRDSSASIALFLEYIPQNLRGWLTAQIEAGDEDAERGCAMVERALAAGTTFMNSRGLLHLDAHFENILTDGRRLYFSDFGLAVFSGFDLSPEEVAFFGRNQSYDRGYTASYLVNLLVANLYGFGWEDREAHTAVVRTLVESKQPEGIPRAAAAIMVRHAPIAAAMTAFIRAFQRASRSAAYPDQEIRQLLDGQGNSAIWHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBG1</accession>
    <name>A0A132PBG1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859539.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02125"/>
    <dbReference type="EnsemblBacteria" id="KWX19587">
        <property type="protein sequence ID" value="KWX19587"/>
        <property type="gene ID" value="AFM11_34900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5709"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="36"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="338" mass="37362" checksum="5FC3B9682830C97B" modified="2016-06-08" version="1">MVRPAAEELPAALETIARQRVPGAAQARVKNWCPSPGGFSTETFLFELDGLDDGGSLGLVFRRPPEFQILPDYDLRRQYLVMQRLAPSPIPVPTVRWIDAEGDALGTQYLVMDRIDDVVGVSDVPPYHGAGIFAETDDAGRAALWNGCVDMIAAVHRLDPQKYRLGFLGKSTPAALRDFLRYAIGWAYGDKPIHPTFRRALDWLDNHLYTPDRVGLCWGDSRMSNVLYRPDLSPAAALDWEIAYLGDQAADLSWLLMTDWVSSPLPDNAPAPGTPSREETIDRYERAVGHEIGNIAFGDVTAPLLLAVALIRLNHRFDLPGVDLADICARRIDFVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBH3</accession>
    <name>A0A132PBH3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_34590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19666">
        <property type="protein sequence ID" value="KWX19666"/>
        <property type="gene ID" value="AFM11_34590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5264"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="160" mass="18133" checksum="16E0CB331F9A7935" modified="2016-06-08" version="1">MPAELHDVILDFRWDIERLHALDLPTCTVAASDLAWHLDLPFWSVRGVQFQISPTEVAANPALHQKHWQRTLAAELRYPLDAYLRWDGQIVVLDGIHRLLKASLMDRTDIPVRVLAPHQFGAIAVLQPLDTIPTDHAAEEFLTRTPVTQDASPTPLRRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBW6</accession>
    <name>A0A132PBW6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ORF">AFM11_33770</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858871.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07985"/>
    <dbReference type="EnsemblBacteria" id="KWX19825">
        <property type="protein sequence ID" value="KWX19825"/>
        <property type="gene ID" value="AFM11_33770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5091"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KWX19825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="276" mass="29537" checksum="66B6254F668DA67A" modified="2016-06-08" version="1">MSWLQVIVLSIVQGLTEFLPVSSSGHLAITSRVFFDDDAGASFTAVTQLGTEAAVMVYFAKDIGRIAKAWCTGLFDAARRNADYRLGWFVIIGTIPIAVFGLLFKDEIRTGARNLWLVASALIVFSAVIAAAEYFGRQTRHVEQLTLRDSVIVGLAQCLALVPGVSRSGATISAGLFLGLDRELAARFGFLLAIPAVFASGLFSLPDAFHPVGEGMSASGPQLLIATLIAFVVGFAAIAWFLRFLVSHSMYWFVGYRILLGTVVLVLLGTGVVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBW8</accession>
    <name>A0A132PBW8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_35640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000046">
        <property type="protein sequence ID" value="KWX19482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31555"/>
    <dbReference type="EnsemblBacteria" id="KWX19482">
        <property type="protein sequence ID" value="KWX19482"/>
        <property type="gene ID" value="AFM11_35640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5863"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX19482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="401" mass="44534" checksum="BD682072146DFBFD" modified="2016-06-08" version="1">MNMRFIFMSEGETVPGHTHEHRYRELVDEVLLAEEVGFDAFGTSEQHVAIGTATTSAPEVIYPYLMALTKRIRFMHLVTLLPTRINHALRVAERLATEDILSSGRVELGVGRGNTTLALRAFEVEPSENKAQLIEGLEVIRRALHNDVFSYVGEHYKIPPRSLVPKAIQHPYPPISMAAGSPESVRKAAELGIGAIVGGFYLGFEFVESMLRIYDEALDGATHTYPLQAQKLVAVGGGMHCAETRAEAVKWARSLKETVALSTDAYERLSKLSADYQYMGAVRNVDFDDERYMFEDSSGFIVGDPDDCAAQVQRFADLGADAIVMRIDGLPHKELMKSIEFFGKYVIPRFKNPRAVVRPADAILADIRTARPAHYAELEAFEESKSQSNSHKSVVTVGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC07</accession>
    <name>A0A132PC07_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33305</name>
        <name evidence="2" type="ORF">AWC31_02410</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858626.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02410"/>
    <dbReference type="EnsemblBacteria" id="KWX19860">
        <property type="protein sequence ID" value="KWX19860"/>
        <property type="gene ID" value="AFM11_33305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13392">
        <property type="protein sequence ID" value="ORX13392"/>
        <property type="gene ID" value="AWC31_02410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4993"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019675">
        <property type="entry name" value="DUF2550"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10739">
        <property type="entry name" value="DUF2550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX13392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="148" mass="16923" checksum="E788A7E01C21B592" modified="2016-06-08" version="1">MSASMIAMVALVGVLLLLVIALCYRLWKLRQVGGTAAILRDFPAVGGHGWRHGVMRYRGGEAGFYRLSSIRWWPDRRLSRRGLEVVSRRSPRGDEFDIMTDQIVILELRDTGSERRQGYEIALDRGALTAFTSWLESRPSPRARRRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC09</accession>
    <name>A0A132PC09_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ORF">AFM11_33295</name>
        <name evidence="10" type="ORF">AWC31_02420</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858620.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02420"/>
    <dbReference type="EnsemblBacteria" id="KWX19858">
        <property type="protein sequence ID" value="KWX19858"/>
        <property type="gene ID" value="AFM11_33295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13394">
        <property type="protein sequence ID" value="ORX13394"/>
        <property type="gene ID" value="AWC31_02420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4991"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX19858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX13394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="417" mass="43962" checksum="07270DB050151D2E" modified="2016-06-08" version="1">MSERFVVTGGNRLSGEVAVGGAKNSVLKLMAASLLAEGTSTITNCPDILDVPLMAEVLRGLGATVELDGQTVRITSPDEPKYDADFAAVRQFRASVCVLGPLVGRCKKAKVALPGGDAIGSRPLDMHQAGLRQLGATCNIEHGCVVAEADHLRGAEIQLEFPSVGATENILMAAVLAEGVTTIHNAAREPDVVDLCAMLNQMGAQVSGAGTSTLTITGVDRLYPTEHRVIGDRIVAATWGIAAAMTRGDISVTGVDPQHLQLVLHKLHDAGATVTQNDDGFRVVQYERPKAVNVATLPFPGFPTDLQPMAIGLASVADGTSMITENVFEARFRFVEEMIRLGADARTDGHHAVVRGIPQLSSAPVWSSDIRAGAGLVLAGLVADGDTEVHDVFHIDRGYPLFVENLVSLGAEIERVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCL3</accession>
    <name>A0A132PCL3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alkyl hydroperoxide reductase AhpD</fullName>
            <ecNumber evidence="6">1.11.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alkylhydroperoxidase AhpD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ahpD</name>
        <name evidence="8" type="ORF">AFM11_32490</name>
        <name evidence="9" type="ORF">AWC31_19625</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="Rhea" id="RHEA-COMP:16355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.11.1.28"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AhpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.28" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX17040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858115.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19625"/>
    <dbReference type="EnsemblBacteria" id="KWX20081">
        <property type="protein sequence ID" value="KWX20081"/>
        <property type="gene ID" value="AFM11_32490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17040">
        <property type="protein sequence ID" value="ORX17040"/>
        <property type="gene ID" value="AWC31_19625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4826"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008785">
        <property type="term" value="F:alkyl hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032843">
        <property type="term" value="F:hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01676">
        <property type="entry name" value="AhpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004674">
        <property type="entry name" value="AhpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00777">
        <property type="entry name" value="ahpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="7">
        <location>
            <begin position="97"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with AhpC); in linked form" evidence="6">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX17040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="177" mass="18953" checksum="29F83DA23CF58D08" modified="2016-06-08" version="1">MSIDNIKEALPEYAKDLKLNFGSIVKSTELTEQQLWGALVATAAATKSQQLLREISEDALDVLSAEAYHAALGAASIMGMNNVFYRTKGQLDGRYDDLRAGLRMNIIANPGVEKADFELWSLAVSAINGCGHCLAAHETVLRDAEVSRSTIFEAIRLASIVSGVAQALLTAETLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCN9</accession>
    <name>A0A132PCN9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ORF">AFM11_32555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858141.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19690"/>
    <dbReference type="EnsemblBacteria" id="KWX20089">
        <property type="protein sequence ID" value="KWX20089"/>
        <property type="gene ID" value="AFM11_32555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4839"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="274" mass="28899" checksum="E1CBB46102FAACB2" modified="2016-06-08" version="1">MTDQLAPIGIFDSGVGGLTVARAIIDQLPDEDMVYVGDTGNGPYGPLTIPEIRAHSLAIGDDLVSRGVKALVIACNTASSACLRDARERYSPVPVIEVILPAVRRAVAATRNGRIGVIGTAATIASGAYQDAFTAARDTEVIGVACPRFVDFVERGVTSGRQVLGLAEGYLEPLQRAEVDTLVLGCTHYPMLSGLIQLAMGDNVTLVSSAEETAKDLLRVLTELDLLRPHETGPARRVFEATGDPEAFTALAARFLGPSLDGVRPVRRHAGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCQ1</accession>
    <name>A0A132PCQ1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_32440</name>
        <name evidence="2" type="ORF">AWC31_19565</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000009">
        <property type="protein sequence ID" value="ORX17033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858095.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19565"/>
    <dbReference type="EnsemblBacteria" id="KWX20074">
        <property type="protein sequence ID" value="KWX20074"/>
        <property type="gene ID" value="AFM11_32440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17033">
        <property type="protein sequence ID" value="ORX17033"/>
        <property type="gene ID" value="AWC31_19565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4816"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX17033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="245" mass="24983" checksum="99442D98236DF976" modified="2016-06-08" version="1">MAGVVVTGAASGIGRASAAALIADGRRVALWDIAPDVRSVAEEFGMPWAVVDVCDTEALSAAVDEAAGALDGIDGLVHAAGRVIPEPVGAYTQESWDAVLDVNLRAQALLMQLLLPHLQKSASDGAAPAVVGISSIEGLSANPFIPAYCASKAGLLGMTRSMAAQLGPLGIRVNAVCPGFIQTPMLQIALDVEEVRVGFEQAAPLGRLGQPDEVAAAVAFLMSPKASFVTGTYLVVDGGVTSRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCQ4</accession>
    <name>A0A132PCQ4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_32470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19605"/>
    <dbReference type="EnsemblBacteria" id="KWX20118">
        <property type="protein sequence ID" value="KWX20118"/>
        <property type="gene ID" value="AFM11_32470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4822"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CHK" evidence="1">
        <location>
            <begin position="98"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="337" mass="36895" checksum="1F54E9FBCC6AACD0" modified="2016-06-08" version="1">MTAALSGHHPDAVVDAVRIAMRDDGTNRRARLAVTYSSGNGPATVFAKAVDPDHKILIKMTSGLLHEPRLFNCGVDLPLEHPTVYAAPIDEADEDFLLVMEDLTARGADPRDATRPLTVDEAASGVRGLARMHGKYWGKRLSDNPALGWLEPFLPWDGMEIAPLPAALERLGDDAPDEVMALTIEGLIDEIWKPYIRSLTRSPQTLLHGDPHIGNTYLLPSGEVGFLDWQVARRGNWSLDLGYFLQGALTIADRRSSEQALLVEYRDALGLPADELPSMDEIWLRYRASVAHGLTLWLCTASAGELWQRPDIALALAQRYSAAYADLQTAAAIADIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD25</accession>
    <name>A0A132PD25_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857438.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25460"/>
    <dbReference type="EnsemblBacteria" id="KWX20229">
        <property type="protein sequence ID" value="KWX20229"/>
        <property type="gene ID" value="AFM11_31305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4166"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="318" mass="34524" checksum="DDA8E41D69EC7BF8" modified="2016-06-08" version="1">MSVGERRAGVSLTNLDEPLAPDAGATKRNLVDYLDGVAEYLLPVLADRPLTVLRILRGQKPFIQKNIPKYTPEWVPRVPIWAEASKREIHYPVCNDRRTLLWLANQRAVEYHPALGLADDIYRPTHLVLDLDPPAGGDFSGVVAVAYLVRQALADCGLAGAVKTSGSRGLHVFVPIDAGSPVDDVAAATRALAARTEALDPSIATTAFIVEDRHGKVFVDSTRSGGATVAAAYSPRLRPGLPVSFPVEWAELKHVKPTDFTVHTALDALAGRRSWSDSMPAPQRLPSDLIQQGHTIPVARVAAMHEGKRRARARRAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDT2</accession>
    <name>A0A132PDT2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857262.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26760"/>
    <dbReference type="EnsemblBacteria" id="KWX20387">
        <property type="protein sequence ID" value="KWX20387"/>
        <property type="gene ID" value="AFM11_31050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4113"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021784">
        <property type="entry name" value="DUF3349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11829">
        <property type="entry name" value="DUF3349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="108" mass="11578" checksum="96BA87BEC3875A48" modified="2016-06-08" version="1">MTTQSLVISILNWLRAGYPEGVPGDDRVPLLALLRATPLTDEQVKEVVRNLTADRSTALVDGSIDHDEIAAFIAEVSHHDAGPENINRVAAKLAAAGWPLAGVERETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE22</accession>
    <name>A0A132PE22_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856519.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25050"/>
    <dbReference type="EnsemblBacteria" id="KWX20580">
        <property type="protein sequence ID" value="KWX20580"/>
        <property type="gene ID" value="AFM11_29710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3834"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009448">
        <property type="term" value="P:gamma-aminobutyric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004632">
        <property type="entry name" value="4NH2But_aminotransferase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00700">
        <property type="entry name" value="GABAtrnsam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="450" mass="46807" checksum="349A4EDF599A0D6E" modified="2016-06-08" version="1">MTASLVGGPALQQVRRVRTDIPGPRSLELAERRAAALPAGLASAAGVYVAAAGGGVVVDVDDNSFIDLGSGIAVTTVGNAAPAVVSKAAAQLAQYTHTCFLATPYEPYIEVAEALNRLAPGDHEKRTALFNTGSEAVENAVKYARAATGRPAVVVFDHAFHGRSLLTMTMTAKNQPYKHGFGPFAPEVYRAPMAYPYRWPSGPENCAAEAFSQFTQLVDAQLGADAVACVVVEPIQGEGGFIVPADGFLAKVADFCRDRGILLVADEVQTGIARAGAWFACEHEGLVPDLITTAKGLAGGMPLAAVTGRADIMDAAHAGGIGGTYSGNPVACAAALGVFEEIEAGGLIERARAIGDLMVRQLREIAATTDVIGDIRGRGAMIAAELVQPGTREPNREAVAALTRHCQDNGVLTLTAGTFGNVLRFLPPLTISDDLLAEAFEVVRDGFANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEA2</accession>
    <name>A0A132PEA2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_31745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857664.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26370"/>
    <dbReference type="EnsemblBacteria" id="KWX20302">
        <property type="protein sequence ID" value="KWX20302"/>
        <property type="gene ID" value="AFM11_31745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4253"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="197"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="347" mass="36827" checksum="02D1F9178CD52999" modified="2016-06-08" version="1">MDRFELRRLDYSLTEDHVDLQTAYKQFFKTHCSIDTVRAAEPSGFDKSLWERLCAMGATTMALPESVGGDGATLVDLTLVAEEIGRSLAPVPWIDHVVAARLLAALGGMESEDILNGTQLVAFDPQQVAPAGTRLIPAGSIADHIIVRDDSDVVRLTFGTRPAKVDNIGKLPMAWVDPAAADSRTIVASGPDALAAYQRALDEWRLLTAAALVGLVEETMTIAAEFAKTRYTLGVPISTLQAISHPLANMAITVEGGRGLSRRAAWFLDNEPDERPELAPSAFVFMAEEASKAATMAVHIQGGLGVSAEAAATAYLVRARGWALAGGDPAATAVHIAGIVAARESKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEK1</accession>
    <name>A0A132PEK1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011331218.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20751">
        <property type="protein sequence ID" value="KWX20751"/>
        <property type="gene ID" value="AFM11_29400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3771"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="288" mass="30180" checksum="F7F1FA145FE3FF05" modified="2016-06-08" version="1">MSQSSSLQGVQVVSLAINLPGPLAAARLRALGATVTKIEPPAGDPLRAVAPTWYDELTVGQRVVTLDLKDPADRAVAARELSRADLMLTAMRPSALVKLGLDELTAANPHLSHIEIVGHDGIAAEQPGHDLTYQALHGTLQPPTMPTVPVADLLGAERAVSAALLALRVAAESGVGHRERVVLEQAAADAGAAVRHGLMGAGAPLGGAHPGYRIYSSSDGHVALAALEPHFWERARAGLGVEGTQEELEQTFLSKPTREWEEVAKRLDIPLIGIRDSAPRNSAQGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEY2</accession>
    <name>A0A132PEY2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_29555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856434.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20552">
        <property type="protein sequence ID" value="KWX20552"/>
        <property type="gene ID" value="AFM11_29555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3802"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="408" mass="45412" checksum="C2FC465C76D6ACAE" modified="2016-06-08" version="1">MSSKGLGVVQRRILDMLARNMNDPMQDWNSGFASWTPIIELAGPTANRAEVESMRRAAVKLADIGMIDVTEIPRQVYSDALQQRIERSVLAARLPLQGEIRRQWEAERAIRGVPDVIDRVDGERRRLNVQIPKESIRSLFLEMVYVGDGDDVTPAPVTTLATGTGFFCRVDGSDFLVTARHNLSGRHWETKEYLSKGHPVAPTHIRIGLRATPPPGGYSLNDAQRIMLYQLALTDDDGPLWREHPTYRDDMDVAVLPMRLPGDDNVLVVPWEPQTAEVADANNKLWVTQDITIVGYPYGLKSGELPLWARGTIASEPSFLYTYNDRELPLFLSDARTRPGQSGSPVLLFRPPGTLVVTDKGEVAITKGTQSKLLGVYTGRVNADSDLGFVWRIGEVWTICRRGVRGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEY8</accession>
    <name>A0A132PEY8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855985.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10390"/>
    <dbReference type="EnsemblBacteria" id="KWX20909">
        <property type="protein sequence ID" value="KWX20909"/>
        <property type="gene ID" value="AFM11_27870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3448"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="110" mass="12409" checksum="3E2CF421003212A4" modified="2016-06-08" version="1">MVEDQVLDRAYSALADPTRRWLLKTLREGDARISDLAAPLPMTFAGVSRHIGVLESAGLVQREIRGREHWLSLKPDGLTMAQQWINEQTDFWSTRADALAARLRRKGQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEY9</accession>
    <name>A0A132PEY9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_27690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855667.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20883">
        <property type="protein sequence ID" value="KWX20883"/>
        <property type="gene ID" value="AFM11_27690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3412"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="170" mass="18415" checksum="2E23BBCA10331280" modified="2016-06-08" version="1">MILSKVRDPRLVTIRRGGTLTDSDHCLLALWAASCAEHVLHLFESARPDDLRPRQAIEQIRAWVRGEVTMMQARAAGGHAMGAARDLRGAPRHAAYAAGQAGAVAHVAAHDLGAAAYAIKAVRAAAPDDGEAAGRLECRWQHAQLPEAIRELVLDDQPLRNDICWSVFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFE5</accession>
    <name>A0A132PFE5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACP S-malonyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06830"/>
    <dbReference type="EnsemblBacteria" id="KWX21033">
        <property type="protein sequence ID" value="KWX21033"/>
        <property type="gene ID" value="AFM11_26980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3270"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="302" mass="30783" checksum="0CEA3E9C145DA761" modified="2016-06-08" version="1">MLALLAPGQGSQTPGMLAPWLELAGAADRLATWSQISGLDLTRLGTTATAEEITDTAVTQPLVVAATLLAHEELTRRGLVNQADVVAAGHSVGEIAAYAIAGVISADDAVKLAATRGAEMAKACAIEPTGMSAVLGGDEAEVLARLESLDLVPANRNAAGQIVAAGAVAALEKLAEDPPAKARVRQLATAGAFHTHYMASALDGYAAAAQSVTTAEPTATLLSNADGQPVSSAADAMEKLVAQLTKPVRWDLCTATLRERAVTGIVEFPPAGTLVGIAKRELKGTPTRAVKSPADLDGLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFF2</accession>
    <name>A0A132PFF2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855300.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06970"/>
    <dbReference type="EnsemblBacteria" id="KWX21051">
        <property type="protein sequence ID" value="KWX21051"/>
        <property type="gene ID" value="AFM11_27120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3299"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="261" mass="27357" checksum="1CC06DC92CE88E9E" modified="2016-06-08" version="1">MTEPTYEAITFEQSGAIARITLNRPDAANGMNHTMTRELADAARRCDTVGTKVVVLTGSGRFFCAGGDLKAFSTVPARGQFIKGVADDLHRAISSFARMDAVLITAVNGTAAGAGFSLAVTGDLVLAAESASFTMAYTKVGLTPDGSSSYYLPRLVGMRRAQELMLTNRTLSAAEAQDWGLVTEVVADADLAERAGKLAEQLAGGSAGSNGAVKTLLLSSLKNSLEEQMEAEGRLIAARADSADGREGVDAFLAKRRPEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFW5</accession>
    <name>A0A132PFW5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diacylglycerol acyltransferase/mycolyltransferase Ag85A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_26745</name>
        <name evidence="4" type="ORF">AWC31_22590</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855078.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22590"/>
    <dbReference type="EnsemblBacteria" id="KWX21249">
        <property type="protein sequence ID" value="KWX21249"/>
        <property type="gene ID" value="AFM11_26745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15383">
        <property type="protein sequence ID" value="ORX15383"/>
        <property type="gene ID" value="AWC31_22590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3220"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453301" evidence="2">
        <location>
            <begin position="24"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX21249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX15383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="333" mass="35444" checksum="3B82AC59A298527D" modified="2016-06-08" version="1">MKFVGKMRGAAAGLSRRLTVAAAIAAVLPGLVGVVGGSATAGAWSRPGLPVEYLEVPSAAMGRNIKVEFQSGGPGAPALYLLDGMRAREDQSGWDIELPTFEWFLNSGISVVMPVGGQSSFYADWYKPACGSKDGGCKTYKWETFLTQELPAWLSANRDVKPTGSAVVGLSMAGSSALMLALRHPQQFIYAGSLSGTLNPSEGWWPTLIGVSMGDAGGYKAEDMWGKSDDPAWKANDPTENVAALANSGIRLWVYCGNGKPGELGGTDMPAKFLEGFVCRTNSTFQEKYIEAGGRNAVFNFPQSGTHNWAYWGQQLQAMKPDLQRVLGATPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFY0</accession>
    <name>A0A132PFY0_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ORF">AFM11_26375</name>
        <name evidence="7" type="ORF">AWC31_22940</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854892.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22940"/>
    <dbReference type="EnsemblBacteria" id="KWX21184">
        <property type="protein sequence ID" value="KWX21184"/>
        <property type="gene ID" value="AFM11_26375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15444">
        <property type="protein sequence ID" value="ORX15444"/>
        <property type="gene ID" value="AWC31_22940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3143"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX21184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX15444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="171" mass="19429" checksum="D6683733AE087B37" modified="2016-06-08" version="1">MSNYSTAILAGGCFWGMQDLIRKQPGVVSTRVGYTGGRNDHPTYRNHPGHAEAIEIVYDPAQTDYRALLEFFFQIHDPTTKDRQGNDVGTSYRSAIFYLDDEQKRIALDTIADVDASGLWPGKVVTEVTPASDFWEAEPEHQDYLLRYPNGYTCHFPRPGWKLPRRETASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFY4</accession>
    <name>A0A132PFY4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">katG</name>
        <name evidence="12" type="ORF">AFM11_26810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855105.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22525"/>
    <dbReference type="EnsemblBacteria" id="KWX21258">
        <property type="protein sequence ID" value="KWX21258"/>
        <property type="gene ID" value="AFM11_26810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3233"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="140"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-106)" evidence="8">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX21258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="734" mass="81052" checksum="414C49E71E50F373" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG30</accession>
    <name>A0A132PG30_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_26270</name>
        <name evidence="11" type="ORF">AWC31_23330</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000013">
        <property type="protein sequence ID" value="ORX15509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854837.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23330"/>
    <dbReference type="EnsemblBacteria" id="KWX21167">
        <property type="protein sequence ID" value="KWX21167"/>
        <property type="gene ID" value="AFM11_26270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX15509">
        <property type="protein sequence ID" value="ORX15509"/>
        <property type="gene ID" value="AWC31_23330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3121"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="36"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX21167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX15509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="273" mass="29691" checksum="6264C10AB012AF04" modified="2016-06-08" version="1">MSVESTARTQLVYAPRGWRRLRGLVLRMGAFALVELQKLRHDRTELFTRLVQPALWLLIFGQTFSRLHLVDTGGLPYLTFLAPGIIAQSALFISIFYGIQIIWDRDAGILAKLMVTPAPASALVTGKAFAAGVRSVVQVLGVVVLAYLMGIAMTVNPLRILAAMGVVVLGSAFFACLSMTLAGLVRKRDRMMGIGQAITMPLFFASNALYPVDIMPGWLRWLSAVNPLSYEVNALRGLLIGTPTNWLLDITVLVVAAVAGVAVASTLLRRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG69</accession>
    <name>A0A132PG69_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854478.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36205"/>
    <dbReference type="EnsemblBacteria" id="KWX21320">
        <property type="protein sequence ID" value="KWX21320"/>
        <property type="gene ID" value="AFM11_25690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3002"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="125" mass="13115" checksum="53C8FBA91A0D96DB" modified="2016-06-08" version="1">MIQPPAVRYAGFLTAAEGVAAFVMAVVLVVRAVGGADQHIVSGYGTAIWFVLIGGGVLAGGWALITGRRWGRGIAVLTNLLLLPVAWYVVTSHHIVYGVMVGLLAVVTLGLLFSPSAVEWLTSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGC2</accession>
    <name>A0A132PGC2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855271.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21042">
        <property type="protein sequence ID" value="KWX21042"/>
        <property type="gene ID" value="AFM11_27035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3280"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453251" evidence="1">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="165" mass="17506" checksum="8C4A4CFCC9022044" modified="2016-06-08" version="1">MKNLILAVAVSTAIGFALGGMKASGPAPVVAAPPIPTPGVYDVTESTAASAWAPYAWTLSDCGKECLHVLSHSSDTQWELDLAWSATADGNRGAWVGERTNPGMACLVGTPQAYQTGPFAMKYIIRPDLTGFVNMKFSQDNPSCSGETDMRSRELALRRAPAVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGJ8</accession>
    <name>A0A132PGJ8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853989.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27015"/>
    <dbReference type="EnsemblBacteria" id="KWX21433">
        <property type="protein sequence ID" value="KWX21433"/>
        <property type="gene ID" value="AFM11_24760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2313"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="228" mass="24667" checksum="804718046F310919" modified="2016-06-08" version="1">MDSETKPWEGVIPAEDLASFAREFDKEDRPLTAGTRPAVLVIDMTRAFVDSTYSTGWSETGYPAVDATAELLTAARAAGVPIFFTKAYPEADHQPLPAERGRWKLNAAPAALPEGTPPGDVIADKLAPQPDEIVINKGGKPSGFFGTPLASYLIHAGCDTTIVTGMTTSGCVRATVLDAFQYNFHVIVPHECTADRSQISHKVNLFDMHMKYADVIGVRQTINYLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGN4</accession>
    <name>A0A132PGN4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_25070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854139.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27390"/>
    <dbReference type="EnsemblBacteria" id="KWX21486">
        <property type="protein sequence ID" value="KWX21486"/>
        <property type="gene ID" value="AFM11_25070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2375"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="19"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="275" mass="30395" checksum="A01F4CDBA213D035" modified="2016-06-08" version="1">MNPRVTLNDGNSIPQVGLGVWQTPAEDTERAVTAALQAGYRHIDTAAAYQNETETGRAIANSGVPREDIFLVTKLWNSDQGYDTTLAAFDASLERLGVDYLDLYLIHWPMPAKNTFIDTFKAFAHLHDQQRVRSIGVSNFEPEHLNILIDATGIVPAVNQIELHPLMPQQELRDVHAKLGIATEAWSPLGQGSLLSDPVITGIADRHGKTPAQVLIRWHIHLGNIVIPKSVNPERIVSNFDVFDFDLSEEDMTSIASLENGTRLGPDPRTFNFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHC4</accession>
    <name>A0A132PHC4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853945.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21740">
        <property type="protein sequence ID" value="KWX21740"/>
        <property type="gene ID" value="AFM11_24585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2278"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453346" evidence="1">
        <location>
            <begin position="30"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="101" mass="9651" checksum="30EFD7955A4FCE9C" modified="2016-06-08" version="1">MLTIRKLLGSVFVAGAAAAIAAGPTAALLADAPATFTDLTGTNQVVLATPSGSGDAGGGGGCDSGPNWHGCGGWNPAQGGWGHGCINGICGGWDGQRGWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI31</accession>
    <name>A0A132PI31_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ectoine dioxygenase</fullName>
            <ecNumber evidence="6">1.14.11.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ectoine hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_22950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-ectoine + O2 = 5-hydroxyectoine + CO2 + succinate</text>
            <dbReference type="Rhea" id="RHEA:45740"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58515"/>
            <dbReference type="ChEBI" id="CHEBI:85413"/>
            <dbReference type="EC" id="1.14.11.55"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. EctD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.55" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852898.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08255"/>
    <dbReference type="EnsemblBacteria" id="KWX22018">
        <property type="protein sequence ID" value="KWX22018"/>
        <property type="gene ID" value="AFM11_22950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1943"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012774">
        <property type="entry name" value="EctD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02408">
        <property type="entry name" value="ectoine_ThpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX22018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="296" mass="32479" checksum="630259BFAF5EC540" modified="2016-06-08" version="1">MSASLALEDPYPTRLDHAIAPIPRQDPTVWGSATDGPLDQDHLDRMSAQGYLIRPDTVADDQLPSLRHELDRIAADLEPGDPRVIREPGGSIRSIFEPHLLSELVAEVVRLDTVLPVARQLLGSDVYIHQARINLMPGFTGTGFYWHSDFETWHAEDGMPAIRAVSCSIALTHNYPYNGSLMVIPGSHQTFYPCVGATPEDNHDTSLVVQSIGVPDETTLTKAVDQHGIDQFTGPPGSALWFDANLLHGSGSNITPLPRSNIFLVFNSVENKLEEPYAAPRRRPEYLAARCATSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIG8</accession>
    <name>A0A132PIG8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldolase_II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852446.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04620"/>
    <dbReference type="EnsemblBacteria" id="KWX22136">
        <property type="protein sequence ID" value="KWX22136"/>
        <property type="gene ID" value="AFM11_21815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1711"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="6"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="238" mass="25550" checksum="84A3EDB7B3C33671" modified="2016-06-08" version="1">MNDLRGVVATACRMLAHQGLAADVLGHVSVRLDADRILLRCRGPADRGLLFTVPDDIRVVHLDGRVDVAGGYAVPNEVHIHTELFRARPDVQAIVHAHPSDVMVADLAGLEPRQVFGAYNIPASRLAYRGVPVYPRAVLIRTPELGRAVAAAVGESAACILRGHGIVTAGESVEQATMCALDLAELSRITAEIKRLGGAPEPLPDKDRDELPDLGASFNDSSRWRHYASRLEIAGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ16</accession>
    <name>A0A132PJ16_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852213.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06545"/>
    <dbReference type="EnsemblBacteria" id="KWX22336">
        <property type="protein sequence ID" value="KWX22336"/>
        <property type="gene ID" value="AFM11_21180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1583"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="258" mass="27052" checksum="30CCF854D399FE9D" modified="2016-06-08" version="1">MTAEIHPTSWAQAVDELVDPGAVVVAGGTGVQPWLTTSGATPHALVHLRTIREAWDVEPLADGLRLGAMVSVDHPLFASWFGDEGAAWFATPAVRRRATVLGNAMSPMGPRELGPILVATGARILVSAGGAEADWKSVEQAMGQWVSLRKLAMTIELCRPERISYRRVSARTRMSRVEVGVCAAIGPGCGAALVVQSGGAVHRLTGAATSSDRADFVAAACDALVALPRSAEVDGEIIAMVTGLAERVHRDLHGPRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ61</accession>
    <name>A0A132PJ61_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06550"/>
    <dbReference type="EnsemblBacteria" id="KWX22375">
        <property type="protein sequence ID" value="KWX22375"/>
        <property type="gene ID" value="AFM11_21185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="151" mass="15164" checksum="96CB49604A0460D2" modified="2016-06-08" version="1">MGGTASLWDVLEQAGMAPPFGCGTGHCGACTVLIDGVPSPSCVVPSGALPNTAVNTVATAALRELVDALAAEGAVQCGFCSPGMVVTLSWAVCRAAAEHRVLTATEVREQLVGHLCRCTGYQSIVAATVATSRNLQTVSRAAAPGSALGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJC4</accession>
    <name>A0A132PJC4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Molybdenum ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_19865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851855.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28650"/>
    <dbReference type="EnsemblBacteria" id="KWX22413">
        <property type="protein sequence ID" value="KWX22413"/>
        <property type="gene ID" value="AFM11_19865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1307"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="8">
        <location>
            <begin position="291"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX22413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="361" mass="37935" checksum="EE758066CD5C852C" modified="2016-06-08" version="1">MTQRLQVRAVVEQRGLDIDFDVAAGEVLAVLGANGAGKSTTLHVIAGLIDPDAGRVRVGDRVLTDTAAGVQIATHDRRVGLLLQDPLLFPHLSVEANVAFGPRSMRRSSRTAARDSAQRWLAEVDAAELAGRRPRQLSGGQAQRVALARALAADPDVLLLDEPLTGLDVAAASAMRKVLRRVLTRESRCAVLITHDLLDVLTLADRVLVLESGKIVENGSTATVLATPRSHFAARFAGVNLIGGTAAEGGVLTTAWNAHWHGTPADDVMAGTRAVAVFAPSAVAVYRDEPHGSPRNTIAVTVAELDSRGPGIRVRADEQPDGAPGLAADITAESAAELRLAPGERVFFSVKAQEVAVHPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJE1</accession>
    <name>A0A132PJE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851912.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22469">
        <property type="protein sequence ID" value="KWX22469"/>
        <property type="gene ID" value="AFM11_20165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1368"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="291" mass="30695" checksum="23A0A64C00BA2034" modified="2016-06-08" version="1">MKYAVVAPVAAGVTADPVWMSTFARHTEACGFESIVVVEHTVLMAEYSSVYPYDTSGRVELSADCPVPDPLDLLAFLAGQTTRLGLATGVLVLPNHHPVVLAKRAATVDALSGGRLRLAVGTGWLKEEIEACGAAFASRGRRADEQIAVLRTLWADQPAGAEFHGEFFDFAHAMSYPKPARPIPIHIGGHSRAAARRAGRLGDGFQPLGVAGAELDELLAVMRAEADETGRDPSALELSLGHLVTKIDADRAGRLADLGADRLVLAMPPLGDIAEACDTLSACARRLGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJF8</accession>
    <name>A0A132PJF8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_21090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852187.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06455"/>
    <dbReference type="EnsemblBacteria" id="KWX22327">
        <property type="protein sequence ID" value="KWX22327"/>
        <property type="gene ID" value="AFM11_21090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1565"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="69"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="428"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="461"/>
            <end position="468"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="641" mass="71815" checksum="36367FE9A3C80F6F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJS2</accession>
    <name>A0A132PJS2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_19025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22599">
        <property type="protein sequence ID" value="KWX22599"/>
        <property type="gene ID" value="AFM11_19025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1139"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="407" mass="41373" checksum="8CECCC97A8B83AE6" modified="2016-06-08" version="1">MKTAPDPGLHNTTVWFMAFAAALGTATIYPLQPAIADVGASLDISLSEVGLALAFGPLGYLVGLAVLVPLVDRFPPRYVLAAQFGMLACALVANAAAGTTWLLGLTVGLVGAGSAVGAQLSSVAGRFAATSRRATVLGIVTAGISAGIIGGRIVGGWLTEVFGWRGTLLVFAVLCVAFSLFALSVLPGAPGNITTGYLAVLRGMPGLYLRFPALRLAAGRGALWFFAFCAVWSGIAVALAQPPFSYSAEQIGLFAVAGLLGMVATRVAGSWTDRVGARIVILVGLVIAGLSAAMLAWCLSNTVATLIGLALFDAGLFAAQVANQSTVLAIEPAAPARFNSAYMVVYFIGGSLGTAFGAAAVGWLGWPGTATVTVAMIAAAMVLTAVPTKRDVRETAAQSSLMPHGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJX0</accession>
    <name>A0A132PJX0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851603.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15160"/>
    <dbReference type="EnsemblBacteria" id="KWX22603">
        <property type="protein sequence ID" value="KWX22603"/>
        <property type="gene ID" value="AFM11_19060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1145"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1801" evidence="2">
        <location>
            <begin position="36"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="135" mass="15590" checksum="84C741D4C59FBE09" modified="2016-06-08" version="1">MTEPKLLSGGNPQIPKDEGDGPVRDYISAMPDWKHQVGKRLDKLIVRTVPGVHKAVKWNQPFYGHKDEGWFLSFRCYTNYVQVQFLKGASLNPMPPKSSKHPEVRYLDIREDDELDEEQLRSWIEQASKLPGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK12</accession>
    <name>A0A132PK12_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_20515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851972.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22527">
        <property type="protein sequence ID" value="KWX22527"/>
        <property type="gene ID" value="AFM11_20515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1440"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="88" mass="10097" checksum="CDA2D3D642A1503E" modified="2016-06-08" version="1">MARWRARRSRWRARRLERGAKIIVLTDNPHKRVTIVPACHIDSLDGEKNFFEDGDSLVGMVIEGGTVEYDAADRTYIVRLCGEWHAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKA5</accession>
    <name>A0A132PKA5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851647.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15265"/>
    <dbReference type="EnsemblBacteria" id="KWX22627">
        <property type="protein sequence ID" value="KWX22627"/>
        <property type="gene ID" value="AFM11_19195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1173"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="199" mass="22125" checksum="D05E368E2B28E67F" modified="2016-06-08" version="1">MAGDRRGAPGSLTADDWLQAGYELLATDGLRALKIERLCEQIGATRGSFYWHFTDMKGYRSALVASWNSFLENDRRSLAEIEHLPPRERLSKMMEALVSPQHWTLERAMREWARSDDVAAANIRAADHRVLVAVSKAYLDYGFSPEEARLRAESTFAAGIGMLHLIDSTAQLATSDRHERFLDLMLGTTGRAGSQPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKA7</accession>
    <name>A0A132PKA7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase</fullName>
            <ecNumber evidence="1">3.5.1.118</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtC</name>
        <name evidence="3" type="ORF">AFM11_19590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide</text>
            <dbReference type="Rhea" id="RHEA:42684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="ChEBI" id="CHEBI:82706"/>
            <dbReference type="EC" id="3.5.1.118"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.118" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851776.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15660"/>
    <dbReference type="EnsemblBacteria" id="KWX22694">
        <property type="protein sequence ID" value="KWX22694"/>
        <property type="gene ID" value="AFM11_19590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1251"/>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02036">
        <property type="entry name" value="EgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017808">
        <property type="entry name" value="EgtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032889">
        <property type="entry name" value="EgtC_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03442">
        <property type="entry name" value="TIGR03442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="24725" checksum="BC2DB7150743538C" modified="2016-06-08" version="1">MCRHLGWLGEPRSVASLVLEPPQALLVQSYAPRRQKHGLMNADGWGAGFFSPDLPTPARWRSDKPLWGDASFASVAPALRSGCIVAAVRSATIGMPIEPSASAPFSDGQWLLSHNGLVDRAVLPLTARAESAVDSAVLAALIFERGLDALGDTIVEVGGRDPNARLNILAANGSRMLATTWGDTLSLLRCSDGVVLASEPYDDDPGWQDIPDRHLVHVQDSHVELTPLKGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKC7</accession>
    <name>A0A132PKC7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein AFM11_19315</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19315</name>
        <name evidence="4" type="ORF">AWC31_15400</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851689.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15400"/>
    <dbReference type="EnsemblBacteria" id="KWX22647">
        <property type="protein sequence ID" value="KWX22647"/>
        <property type="gene ID" value="AFM11_19315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17810">
        <property type="protein sequence ID" value="ORX17810"/>
        <property type="gene ID" value="AWC31_15400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1196"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX17810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="110" mass="11102" checksum="6D72F3F593A85485" modified="2016-06-08" version="1">MQPGGTPDMSALLAQAQQVQQQLMEAQEALANSEVQGQAGGGLVQVTVKGSGEVVAVRIDPKVVDPNDVETLQDLIVGALADASKQVTILAQSRLGPLAGGLSGFGIPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKD8</accession>
    <name>A0A132PKD8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFM11_17830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851167.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22806">
        <property type="protein sequence ID" value="KWX22806"/>
        <property type="gene ID" value="AFM11_17830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.920"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="308"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KWX22806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="484" mass="54260" checksum="9DDFD440773177B8" modified="2016-06-08" version="1">MRRLKGEDNSFLAWESETQPQHTIKAVVMDPAQGHEPITFESVKATLPGLVDHIEPLQWQLHMPRVGFGRPWWRARSGLDMDYHVQRVTAAAPGGDRELAATIAALCRSVLDRNRPAWQMFYVDGLSDGRIALVLKIHHAVADGSASLRLLELIYSADPATRLPAPRRIPLPDERRPRARTWYRLVLRHQFAALTRFPGIVSRTVAVTKTIRRRQQAGLPGYAEAFTAPPAPFNEPLTADRRFAYHACDLAEIRAVAKAFDVTINDVFLAICSGALRAHLHDDRALPDEPLTAVVPVSMRPPGCEADWGNQVARWNIDFATHIADPVQRLNAIAGATRIARDVQAERDAWLQHDWMEYWPLFWVYSRVLPILGARVKRRPMFSLIASNMRGPQRRLHWDGAPVERLISSGPLVFPMGLNFTGWSYLDEMVISVLCCGDQLSDPGRITDAMAGVLDELSTRAGSLPVQAVEQRDRQPRTGVHVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKF9</accession>
    <name>A0A132PKF9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_19490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15575"/>
    <dbReference type="EnsemblBacteria" id="KWX22677">
        <property type="protein sequence ID" value="KWX22677"/>
        <property type="gene ID" value="AFM11_19490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1231"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="394" mass="41768" checksum="E24045A2646FA4DC" modified="2016-06-08" version="1">MNTADVVIVGGGLEGAAAAWALSQRGVTDVLVAERNTVGSGMTGKSSGIVRCHYGVSSLAAMAAVGLEVFERADEIFGDDIGFRQTGYVVGVGEPNVDALRKSLAAQREVGVQTEEIDKSEVAELWPWADLSPFAAFGWEARGGYGDAYQTAQAFAMSARTAGVRIRQGCNVTDLLIDGDKVTGVRLADGTEVSARTVVVATGAWTRPFLEPYGVDVPIRVVREQIVTISPGLQIGKVPVFSDLVSLQYVRPELGGEILFGNSDLAHCEETDPDNYLNRATDDFVDLTVEKVSGRFPGLPNASITGSYAGCYDVTPDWNPVISATGVDGLVVAAGFSGHGFKIAPAVGRLVADLVIDGRSGDPRIPETDFRLSRFAEDNLLKSPYPYVGAGEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKG5</accession>
    <name>A0A132PKG5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_18065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851250.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12135"/>
    <dbReference type="EnsemblBacteria" id="KWX22839">
        <property type="protein sequence ID" value="KWX22839"/>
        <property type="gene ID" value="AFM11_18065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.969"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="665" mass="72273" checksum="D4A7F650FD8332ED" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKJ5</accession>
    <name>A0A132PKJ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_18260</name>
        <name evidence="6" type="ORF">AWC31_12330</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851311.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12330"/>
    <dbReference type="EnsemblBacteria" id="KWX22869">
        <property type="protein sequence ID" value="KWX22869"/>
        <property type="gene ID" value="AFM11_18260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18768">
        <property type="protein sequence ID" value="ORX18768"/>
        <property type="gene ID" value="AWC31_12330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1009"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX18768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="196" mass="21723" checksum="7DB2F2DF26230C27" modified="2016-06-08" version="1">MTETTTRDRLVTEAMRLFSEQGYRATSVAQIEAAAGLAAGSGALYHHFKSKESLLEAGIDRQLDRRRAMHDIRAMFAGLGDLRTELTLLGRYLLNVIDEESQLLQIAARTPSDRSSRLNDAYAALVDGLYTELDDWIHGWVADLEPAQSRTIATVGINALLGKRATAMFFQAADTPDDEYLTEWTTMLAARITPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKS3</accession>
    <name>A0A132PKS3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_19115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851620.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15185"/>
    <dbReference type="EnsemblBacteria" id="KWX22612">
        <property type="protein sequence ID" value="KWX22612"/>
        <property type="gene ID" value="AFM11_19115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1157"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07970">
        <property type="entry name" value="OBF_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044117">
        <property type="entry name" value="OBF_LigC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="14"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_ligase_A_C" evidence="4">
        <location>
            <begin position="224"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="361" mass="40541" checksum="444783DA514C7B05" modified="2016-06-08" version="1">MEPVDLPVQPPIEPMLAKAQVKVPDEAGVWSYEPKWDGFRALVFRDGDDVVLQSRNGKDLGRYFPELLDALRDELVDRCVLDGEIVVPREIGGRIRLDWESLSQRVHPAASRIKMLSEQTPAHFIGFDALATGDRSLVGEPFRVRRAALAEAVKNKQWCHVTRTTEDPELGTQWLKTFEGAGLDGVIAKRLDGPYLPGKREMVKVKHHRDADCVAIGYRIHKSGEGIGSILLGLYRADGELQMVGGAASFTAKDRLKLLADLEPLREGDEVREGDPSRWNSAADKRWIPVRPEKVCEVAYDQMEGNTEHGAGLPATSGHGQRFRHAVKFLRWRPDREPSSCTFDQLDTPLNYDLYDVLEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKW6</accession>
    <name>A0A132PKW6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851374.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12590"/>
    <dbReference type="EnsemblBacteria" id="KWX22894">
        <property type="protein sequence ID" value="KWX22894"/>
        <property type="gene ID" value="AFM11_18565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1049"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="22"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="337" mass="36461" checksum="8E32DA2C4C41961B" modified="2016-06-08" version="1">MSVALPSTDHRQLGANGPVVSPIGLGFMSFRTGAGPEDEKQAKELVDTAIDLGVTLFDTADVYGPEFSEILLGKAIRGRRDSLVIATKFGNALDRDTNPDARALDGRPEYVRTAIEGSLRRLGIDHVDLYYQHRVDPEVPIEDTVGALKELVDAGKIRYIGLSEPGPQTLRRAHAVHPIAAIQNEWSLFTRDIENDTAPIARELGIGIVPYSPLGRGWLTGRVRTTADVKGVQSRHPRFGADVFDRNRALADNVAAVAAEIGVQPSQVALAWVLSRGRDVVPIPGTRHAEYLRENVGALSVELTAEHLERLDTIAEGVGGHRSIRPEHLGTEAPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKW7</accession>
    <name>A0A132PKW7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_16580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850675.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22990">
        <property type="protein sequence ID" value="KWX22990"/>
        <property type="gene ID" value="AFM11_16580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.665"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="43"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX22990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="409" mass="46195" checksum="19F0EEB98F79731D" modified="2016-06-08" version="1">MTGVKERLSSPLITDDWKVSGQIYRDPAIFAREMATVYARTWVYVGHESEIPSNGDYKTAHIGLQPVIVSRSSDDDTINVMFNRCRHRGSAVCQQEFGNANFFRCAYHGWTYTSAGKLTGVPFDDGYGTDFNKEEMGLAHVAQVDTYRGFIFATLSPTTPALHSYLGNARKYLDFISDLSPEGIELSSHAHKLVFRGNWKLQIENTIDPYHFSFTHQSWLDILRERNGKSSPWVKNVKTNRSWRGIDLGGGHAVHEYGDPTAEKDTHGIAIGELIPFNLNVFPSLAFVGAHLRLVVPRSANETWVYLYPIFPRGADEQTRNRILRDHESFYGPAGHGSADDIEVGFDRVTAGLEATASPADWTLMTRGLEREEIDPETGIRVGRSTDEVPQRAYLRRWLQLIEDRDDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKY6</accession>
    <name>A0A132PKY6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dxs</name>
        <name evidence="12" type="ORF">AFM11_18110</name>
        <name evidence="13" type="ORF">AWC31_12180</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851266.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12180"/>
    <dbReference type="EnsemblBacteria" id="KWX22847">
        <property type="protein sequence ID" value="KWX22847"/>
        <property type="gene ID" value="AFM11_18110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18745">
        <property type="protein sequence ID" value="ORX18745"/>
        <property type="gene ID" value="AWC31_12180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.979"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX22847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX18745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="637" mass="67749" checksum="45CBA8E4A898C684" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLJ3</accession>
    <name>A0A132PLJ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850817.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01545"/>
    <dbReference type="EnsemblBacteria" id="KWX23057">
        <property type="protein sequence ID" value="KWX23057"/>
        <property type="gene ID" value="AFM11_16975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.748"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025196">
        <property type="entry name" value="DUF4126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13548">
        <property type="entry name" value="DUF4126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4126" evidence="2">
        <location>
            <begin position="3"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="206" mass="21271" checksum="C13F856444C154E9" modified="2016-06-08" version="1">MELLTGFGLATAAGLNAYIPLLALGLLSRFTDLVALPAGWAWLENGWVMAIVAVLLVVEVVADKIPALDTVNDTIQTFVRPTAGGIVFGSGTASQTAAVTDPGAFAQSGQWVPVAIGVVTALAVSLTKSAVRPAANVASAGMAAPVLSTVEDVTSVGLVFVAILVPVLVLVALLALAWGVFRLWRWRRRRAEAKTAAPAAGVDSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLW1</accession>
    <name>A0A132PLW1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_16150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850483.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16755"/>
    <dbReference type="EnsemblBacteria" id="KWX23338">
        <property type="protein sequence ID" value="KWX23338"/>
        <property type="gene ID" value="AFM11_16150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7355"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453443" evidence="1">
        <location>
            <begin position="32"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="388" mass="41024" checksum="6AA026F4A1D31AFF" modified="2016-06-08" version="1">MQKPLAAVGGLFLAAALAGCGSGGQTDTADAPSEPIVEPLVVTYDGGLYVLDGDNLEVKSTIPLDGFLRVNPAGDDAHVLVSTDQGFRVLDASAGQLTDTTFEASEPGHVVPHGERTALFADGSGDITVFDPHDLEGGKPETQTLKSTKPHHGVAVVLSDGSWVRSEGDPDERTGAVAFDSGQAEIARNTECPGLHGETVVEGETVVLGCENGVLTYSDRAFTKIAAPGEYGRVGNLRGHEESPVALGDFKVDPDAELERPNQFALIDTTTNQLRLVTLPQSVSYSFRSLARGPHAEALILGTDGKLYVIDPSTGDTTKTIAVTGQWTEPDDWQQPRPTVFTRGHDVYVTDPATKQLHLVDVESGEVTKSVTLEQTPNELSGAVGHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLZ2</accession>
    <name>A0A132PLZ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OHCU decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850546.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16380"/>
    <dbReference type="EnsemblBacteria" id="KWX23368">
        <property type="protein sequence ID" value="KWX23368"/>
        <property type="gene ID" value="AFM11_15370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7189"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="2">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="OHCU_decarbox" evidence="2">
        <location>
            <begin position="81"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="158" mass="18049" checksum="9F43B87AD9202AC2" modified="2016-06-08" version="1">MHQGMGLEAYNALPMRRAVHAVYECCYSVPLAADLARGRPYADHESLFRQADTLLFSLGEDSIDGVLQAYPLFGCRWAHRPDATAQLETAMADYRRRFGFSFVMYTADCDADTVLACIADRLHNDHETERKVVRNELARINRVRLERMLGPEGGFYNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM41</accession>
    <name>A0A132PM41_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mandelate racemase/muconate lactonizing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_13970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849667.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09500"/>
    <dbReference type="EnsemblBacteria" id="KWX23399">
        <property type="protein sequence ID" value="KWX23399"/>
        <property type="gene ID" value="AFM11_13970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6897"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033978">
        <property type="entry name" value="L-talarate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00134">
        <property type="entry name" value="L-talarate/galactarate_dehydra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="6">
        <location>
            <begin position="153"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="59"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Increases basicity of active site His" evidence="5">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR633978-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633978-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR633978-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR633978-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX23399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="372" mass="41044" checksum="AE2349E15B2B3FCE" modified="2016-06-08" version="1">MSDRIRHLTLSHVVLPLPNPVSDAKVLTGRQKPLTETVLLFVEVATEDGHEGMGFSYSKRAGGPAQYTHLAEIAEVAIGHDPSDIDRIYQSLLWAGASVGRSGVATQAIAALDVALWDLKARRAGLPLAKLLGAHRDSCRVYNTSGGFLQASVDEIKDKATASRESGIGGIKIKVGQPDWKTDLERVAALREHLGDNPLMVDANQQWDRARARRMCRELEQYDLIWIEEPLDAWDAVGHADLSRAFDTPIATGEMLTSVPEHMALIDAGYRGIVQPDAPRIGGITPFLRFATLASHAGLALAPHYAMEIHLHLAAAYPTEPWVEHFEWLNPLFNERIEIRDGRMWLPERAGLGFTLSDQMRALTKERAEFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMA9</accession>
    <name>A0A132PMA9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_16145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850481.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16750"/>
    <dbReference type="EnsemblBacteria" id="KWX23337">
        <property type="protein sequence ID" value="KWX23337"/>
        <property type="gene ID" value="AFM11_16145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7354"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453452" evidence="4">
        <location>
            <begin position="24"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="302" mass="31809" checksum="9931552701178420" modified="2016-06-08" version="1">MIRRWVTAGICLVALLLAACSTPDSVGGRPEIAVTTTILGDVVRQVVGDAADVKVLMKPNADPHSSSLSAADAAQLNSSDLIVYNGLGLEESMQRHVDAAAENGVPTLAVGEHVEPLQFSESEHSGPDPHFWTDPQRMVLAVDAIADRVAELPGIDGAAITANAARYRDELTALSDSMTERFAAIPAERRKLVTNHHVLGYLADRFGFTVIGAVIPSGTTLASPSASDLESLAGAIRTAGVPAIFVDSSQPDRLARVLAEQAGMQVNVVSLYSESLSEPGSPADTYLGMMRANTETIVKQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMB6</accession>
    <name>A0A132PMB6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_14460</name>
        <name evidence="5" type="ORF">AWC31_18365</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849830.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18365"/>
    <dbReference type="EnsemblBacteria" id="KWX23478">
        <property type="protein sequence ID" value="KWX23478"/>
        <property type="gene ID" value="AFM11_14460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17276">
        <property type="protein sequence ID" value="ORX17276"/>
        <property type="gene ID" value="AWC31_18365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7000"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="83"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX17276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="155" mass="17169" checksum="64984C35AFDC1816" modified="2016-06-08" version="1">MQGLVLQLTRVGFLLLLWLFIWSVLRILRTDIYAPTGAVMVRRGLALRGSLLPNRQRRHVARQLVVTDGALAGTRITLGNQPVLIGRADDSTLVLTDDYASTRHARLSPRGSEWYVEDLGSTNGTYLDRAKVTTAVRVPIGTPVRIGKTVIELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMF2</accession>
    <name>A0A132PMF2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_14700</name>
        <name evidence="2" type="ORF">AWC31_18200</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849915.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23516">
        <property type="protein sequence ID" value="KWX23516"/>
        <property type="gene ID" value="AFM11_14700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17249">
        <property type="protein sequence ID" value="ORX17249"/>
        <property type="gene ID" value="AWC31_18200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7049"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX17249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="99" mass="10750" checksum="E0193CA021B2763A" modified="2016-06-08" version="1">MSFDGSTIKYDFAQNHGFLDALDSGLGDARALQDEVNNVFNVLYSVYEGEGAQALQLTHKQLAGLMEQAVQDMVVGNTRGRDQQDLMAALDRANAADLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMI4</accession>
    <name>A0A132PMI4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline-rich antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849974.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18020"/>
    <dbReference type="EnsemblBacteria" id="KWX23546">
        <property type="protein sequence ID" value="KWX23546"/>
        <property type="gene ID" value="AFM11_14880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7087"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019674">
        <property type="entry name" value="Lipoprotein_LpqN/LpqT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10738">
        <property type="entry name" value="Lpp-LpqN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453460" evidence="2">
        <location>
            <begin position="33"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="295" mass="29704" checksum="6A7099237AE81273" modified="2016-06-08" version="1">MIESARRWRVLAAGAAVGLAGVVGLAGNTASAEPLFPLPPGPAAPSPATVTQTVTVAPAAAPVAPAAAGAIPAAPAPVAVPVAAPQTITPASSGTLAEFFKAKGVKMEPQVSHDFRALNIVLPLPAGWTKVPDPNVPDAFAVIADRTSTDLYTPNAQVVVYKLVGNFDPKEAISHGYIDSQQQLGWRTTDMSLADFNGFPSAFIEGSYNSGSQMLNTSRRHVIATSGPDRYLVSLSVNYSAANQGVSASAEAADAIVSGFRVGAPAPAAPPAPAPAAPPAAPGLPGLPQLLGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMS8</accession>
    <name>A0A132PMS8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenic transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_12605</name>
        <name evidence="6" type="ORF">AWC31_02885</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848985.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02885"/>
    <dbReference type="EnsemblBacteria" id="KWX23641">
        <property type="protein sequence ID" value="KWX23641"/>
        <property type="gene ID" value="AFM11_12605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11095">
        <property type="protein sequence ID" value="ORX11095"/>
        <property type="gene ID" value="AWC31_02885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6611"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX11095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="362" mass="39309" checksum="9CA5414D5024DC2B" modified="2016-06-08" version="1">MTSTATTPAQAVVGKLSTLDRFLPVWIGAAMIIGLLLGRWVPGLNTSLERIEIDGVSLPIALGLLIMMYPVLAKVRYDRLDTVTGDRKLLLSSLVLNWVLGPALMFALAWLLLPDLPEYRTGLIIVGLARCIAMVIIWNDLACGDREAAAVLVALNSIFQVAMFAVLGWFYLSVLPGWLGLEQTTIDTSPWQIAKSVLIFLGIPLVAGYLSRRIGEKSKGREWYESTFLPRIGPWALYGLLFTIVILFALQGDQITNNPWDVVRIALPLLAYFALMWGGGYLLGTVLGLGYERTTTLAFTAAGNNFELAIAVAIATYGATSGQALAGVVGPLIEVPVLVALVYVSLALRKRFTSTQPQRSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN72</accession>
    <name>A0A132PN72_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_13315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849325.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23753">
        <property type="protein sequence ID" value="KWX23753"/>
        <property type="gene ID" value="AFM11_13315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6756"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX23753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="290" mass="32485" checksum="C58DF464865B198D" modified="2016-06-08" version="1">MHTIRWPFLAAEALDAGLLTFRELRRFHAGIYPGVWAPRGVELSTKQRAHAAWLWSRREGVIACLSASAVLGAEWVDVSTPAELIHTNRRPPPLLTVYTDTLLPAEVCTISGLPVTTPARTAFDLGRRLELEAGVQRIDALMNATDVKVNEIEAVIAGHPGIRGLRQLRETLLLVDGGAESPYESLTRLLLLKAGFPRPETQIRVLDEYGCVVARIDMGWRRYKVGVEFEGAHHWTDPRQRSRDAERFTRLPELGWTDFKLTSGMLHNDPQRFLDRVAAALIAKGCPKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN89</accession>
    <name>A0A132PN89_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_13455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849389.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03740"/>
    <dbReference type="EnsemblBacteria" id="KWX23775">
        <property type="protein sequence ID" value="KWX23775"/>
        <property type="gene ID" value="AFM11_13455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6785"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX23775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="179" mass="19914" checksum="8E904FD5F5A22CAB" modified="2016-06-08" version="1">MRRLVLRAWVLCFLIMVWTLLWGNVSAANLISGLAIALLITVLLPLPAVPVEGKLHPLSLAKLVALVGYYLVLSSIQVAWLAVRPGPPPLTAVLRAHMPLKSDLVLALAVNIMNLTPGNIVLEIDQSRRMLYVHVLDVGSERSVNRFYRQVDQFQRLLVAAFERESDWQPSSDKEVDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNS9</accession>
    <name>A0A132PNS9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX23999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23999">
        <property type="protein sequence ID" value="KWX23999"/>
        <property type="gene ID" value="AFM11_11565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6390"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453447" evidence="1">
        <location>
            <begin position="23"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="354" mass="38289" checksum="48662A59402651DB" modified="2016-06-08" version="1">MKRFRRTSRLIAPFVAITVVLAACGGPPPVPDTKNLDELYQAAKAEGEVVWFAPKPEAQMQPAIEAFKKKYPGIEVKYTNKKAPDLVTQLNVEQAAERVTFDVSNAGGLTVLPSQPMAAKVDWSNYEVPSEQIFAHDFVYVWAVPKVWAYNTNVITAGDAPNSWDALLEPRWNGGRVSVESRGSFMTVWLLDPALGSGPGLDYAARLAEQAPHYTENTTQAHTLIVSGQTPVGTDLINLVLEDKAKGAPVAVAPVSPTNANKSYLFVPEGAPHPAAGRLLTAFLASKEGQAALVDTYNSIIPTDTDCTEAATNRVIGALCDAGVEWYSETDISQYEQFSEFFPEVEDALGTSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNT1</accession>
    <name>A0A132PNT1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_13000</name>
        <name evidence="3" type="ORF">AWC31_03285</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000031">
        <property type="protein sequence ID" value="ORX11161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014876915.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03285"/>
    <dbReference type="EnsemblBacteria" id="KWX23702">
        <property type="protein sequence ID" value="KWX23702"/>
        <property type="gene ID" value="AFM11_13000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11161">
        <property type="protein sequence ID" value="ORX11161"/>
        <property type="gene ID" value="AWC31_03285"/>
    </dbReference>
    <dbReference type="GeneID" id="66739111"/>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6693"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX11161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="75" mass="8175" checksum="5A182856839A48D6" modified="2016-06-08" version="1">MTSMNGPSARDAGDGQPRAQFLTVAEVASLMRVSKMTVYRLVHNGELPAVRVGRSFRVHAKAVHDLLETSYFDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PP74</accession>
    <name>A0A132PP74_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_12095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848591.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09880"/>
    <dbReference type="EnsemblBacteria" id="KWX24093">
        <property type="protein sequence ID" value="KWX24093"/>
        <property type="gene ID" value="AFM11_12095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6498"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="417"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="506" mass="55725" checksum="3837F4A57B481F49" modified="2016-06-08" version="1">MQIREHAKASPDKPAIILYPSGTVVTFGELEARANRLAHYFREHGLREGDVVAILMENNEHIHAVMWAARRSGLYYVPINTHLTPAEAAYIVDNSGAKAIVGSAALTDVLSGLGSELPNGLPDILLIADGDLDGWQRYPQAVADQPDTPIDDEMDGDLLQYSSGTTGRPKGIKRELPHVPPSETPGMMAALVGFWMHPDAVYLSPAPLYHTAPSVWSMQVQAGGITTVVLEKFDAEGALDAIQKHGVTHGQFVPVMFTRMLKLPESVRNSYDLSSLQRVMHAAAPCPVEIKKQMIDWWGTIVDEYYASSEAIGATLITAEEWLTHPGSVGKAMTSVVHILDEDGNELPPGQAGEIYFEGGQDFEYLNDAEKTASSRDSHGWKTVGDIGYVDEDGYLYLTDRRHHMIISGGVNIYPQEAENMLVVHPKVMDAAVFGVPDDEMGQSVKGVVQTVDPSDATPEFAEELLSWLRERLSHYKCPRSISFEEQLPRTDTGKLYKQELIKKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPE7</accession>
    <name>A0A132PPE7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ethanolamine utilization protein EutN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_11995</name>
        <name evidence="2" type="ORF">AWC31_09980</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848544.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09980"/>
    <dbReference type="EnsemblBacteria" id="KWX24077">
        <property type="protein sequence ID" value="KWX24077"/>
        <property type="gene ID" value="AFM11_11995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09258">
        <property type="protein sequence ID" value="ORX09258"/>
        <property type="gene ID" value="AWC31_09980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6478"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01614">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004992">
        <property type="entry name" value="EutN_CcmL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036677">
        <property type="entry name" value="EutN_CcmL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36539">
        <property type="entry name" value="PTHR36539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03319">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159133">
        <property type="entry name" value="SSF159133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51932">
        <property type="entry name" value="BMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX09258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="83" mass="8524" checksum="C58442A71A21E69D" modified="2016-06-08" version="1">MISATVTGNVWSTRRIDGVPAGAFLEVEIDGSGSRMIAFDVLGSGVGEHVLIAQGSVAASWFTGTPPPIDALIIGSIDNNPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPW2</accession>
    <name>A0A132PPW2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_10205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847512.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18650"/>
    <dbReference type="EnsemblBacteria" id="KWX24343">
        <property type="protein sequence ID" value="KWX24343"/>
        <property type="gene ID" value="AFM11_10205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6079"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX24343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="250" mass="25614" checksum="DD78F3B54E49C284" modified="2016-06-08" version="1">MSESVLVDLVDRVAVLTVNDPDRRNAVTFEMSAALRAAVEAAEANSDVHAVIVTGAGKAFCAGADLTALGAATEEGLRKIYDGFLAVAHCSLPTIAAVNGPAVGAGLNLALAADVRIAGPAALFDPRFQKLGIHPGGGATWMLQRAVGPQVARASLLFGMRFDAEAAVRHGLALSVADDPVAAARELAAGPAGAPREVVLATKASMRATANPGVVDSDQHRIAVDTELGPQARSIESPEFAQRLAAAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ43</accession>
    <name>A0A132PQ43_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847673.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24394">
        <property type="protein sequence ID" value="KWX24394"/>
        <property type="gene ID" value="AFM11_10540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6148"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="117"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="341" mass="36833" checksum="A8F1CE85A9BC17E5" modified="2016-06-08" version="1">MTRGRSTFLKFGAFAIVMAVLTAFLFMTFSEYRGGTYSSYSAVFKDASRLEAGDSVRVAGVRVGTVKSVSLQPDKSVLVEFDTDRSVALTTGTNAAVRYLNLVGDRYLELLDTPDSTRLLAAGSQIPVDRTQSALDLDLLLGGLRPVIQGLNPQDVNALTSSLVNIFQGQGDTLDSLMSKTSSFSNTLGDNNEVIQQLIDNLNQVVGTLNKDGDKFSATIDRLEKLVSGLSEDRDPIGEAITSIDNGTASMASLLTQARPPLAGTVDQLNRLAPLLDDNKAVLDRGLQKGPDNYRKMARLGAYGSWIMYYVCGVSLRVTDLQGRTAVFPWIKQEGGRCAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQ97</accession>
    <name>A0A132PQ97_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ribokinase</fullName>
            <shortName evidence="6">RK</shortName>
            <ecNumber evidence="2 6">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rbsK</name>
        <name evidence="8" type="ORF">AFM11_09495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 6"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847133.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05730"/>
    <dbReference type="EnsemblBacteria" id="KWX24222">
        <property type="protein sequence ID" value="KWX24222"/>
        <property type="gene ID" value="AFM11_09495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5936"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="7">
        <location>
            <begin position="5"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX24222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="286" mass="28436" checksum="EEE1B111FB397140" modified="2016-06-08" version="1">MAASRVCVVGSINADLTFAVRTLPRPGQTVLASSLVSAPGGKGGNQAVAAARAGGNVALVAAVGEDAAAESLRAHLRSNGVNQDAVVSLPGPSGSAVIVVDAAGENSIVVAPGSNSLLEVDSAAARSAICDADVVLLQLEIPATTAIAAARLARAAGAVVMLNASPAGTAAHHLLALSHSVDVVVVNETEAAEWHWPVKHLVITRGSKGASYLGEDERFDVPAPMVRAVDTAGAGDVFAGVLAAGWRSGYEDALRRACAAGALATLVRGAGDCAPNAADIDAVLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQE1</accession>
    <name>A0A132PQE1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846037.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22115"/>
    <dbReference type="EnsemblBacteria" id="KWX24546">
        <property type="protein sequence ID" value="KWX24546"/>
        <property type="gene ID" value="AFM11_07620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5373"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="232" mass="26362" checksum="68DC0E6B876FF0A9" modified="2016-06-08" version="1">MTATTASGKESVSLDEHHEQSRLAQRRADKWMIAGAALMGMWAPGLIGFPIFMRGVWLQRQALRAGYSVRPMIVTLIGYLVLIDGMLNSLGWALDLVANHTLINRVLMVGWGAMFDAGYFWHYNELWIGGAAGPGEKSMVFGMIVTVFAMRCAAAIGFLQMKRWGHQWMIITCWMGVLIWCLYVFNMTMFADVRFAGVVFPVIGWWLYDIFYITPFLAIPYLHTVNREIFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQL6</accession>
    <name>A0A132PQL6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_07900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846174.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24500"/>
    <dbReference type="EnsemblBacteria" id="KWX24595">
        <property type="protein sequence ID" value="KWX24595"/>
        <property type="gene ID" value="AFM11_07900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5430"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="518" mass="54562" checksum="C922A0EEC23B6386" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQM5</accession>
    <name>A0A132PQM5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_10860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847984.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19375"/>
    <dbReference type="EnsemblBacteria" id="KWX24507">
        <property type="protein sequence ID" value="KWX24507"/>
        <property type="gene ID" value="AFM11_10860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6211"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="405" mass="45133" checksum="2DB6AB1E39A0B4DD" modified="2016-06-08" version="1">MTETLTHTEIPDYPMERDARCPFAPPPPMLGNPKGLFRVRIWNGDTPWLITGHEEARTLFSDSRVSVDDRRSGFPHWNEHMLATVDKRPRSVFTSDAEEHTRFRRMLSKPFTFRRVEGLRPAIQKITDDCIDEILAGPQPADIVAKLALPVPTVVISEMLGVPYADHEFFQEHANAGLARYAAADAMQKGAMSLHQYLIDLVEEKQANPAEDAVSDLAERVTAGEISVKEAAQLGTGLLIAGHETTANMIGIGVLALLENPEQAEFLRNAEDPKVIANAVEELMRYLSIIQTGQRRVAIEDIEIGGETIRAGEGIIIDLAPANWDAKAYPEPDKLDLSRDAGQQLGFGYGRHQCVGQQLARAELQIVFHTLLRRIPTLRLAIPLEDVPFKHDRLAYGVYELPVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQQ9</accession>
    <name>A0A132PQQ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_10465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847634.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18900"/>
    <dbReference type="EnsemblBacteria" id="KWX24382">
        <property type="protein sequence ID" value="KWX24382"/>
        <property type="gene ID" value="AFM11_10465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6133"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="254"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="381" mass="40696" checksum="7A8B305F240E51C4" modified="2016-06-08" version="1">MTNDVAIIGVGIHPFGRFDKTAMQMGAEAIQGALADAKLEWKDIQFGFGGSYEVSNPDAVTRLVGLTGITFTNVFNACATAASAIQQTADTIRLGKYDIGIAIGLDKHPRGAFTDDPAKLALPQWYAENGQFVTTKFFGMKANHYIHKHNISQETLARVANKNFRNGALNPNAFRRKEISVDEILNSTVLNYPLTQYMFCAPDEGAAAVIMCRADIAHRYTDKPVYVRASEIRTRTFGAYEVHATSAPLDEDASPTVYAAKAAYEAAGIGPEDVDIAQLQDTDAGAEVIHMAETGLCADGEQEKLLADGATEIHGSIPVNTDGGLIANGEPIGASGLRQMHELVRQLRGEAGDRQVPGNPRVGLAQVYGAPGTASATILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQV5</accession>
    <name>A0A132PQV5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846537.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13755"/>
    <dbReference type="EnsemblBacteria" id="KWX24719">
        <property type="protein sequence ID" value="KWX24719"/>
        <property type="gene ID" value="AFM11_08615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5574"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024031">
        <property type="entry name" value="MSMEG_5819/OxyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04023">
        <property type="entry name" value="PPOX_MSMEG_5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="140" mass="15633" checksum="2CA36BF065197C39" modified="2016-06-08" version="1">MTFKPHEIAYLNEADLGRLATVQPDGTLQNSPVGFSYNEQLGTIDVAGYRMSHSQKYRNIAHNNRVAFVVDDITSRDPWRVRCLEIRGTAEQAQVPVTTGKGGDELDSAIIRITPQRIISFGIDDQESEPHQLVPDIRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQX4</accession>
    <name>A0A132PQX4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847825.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19340"/>
    <dbReference type="EnsemblBacteria" id="KWX24442">
        <property type="protein sequence ID" value="KWX24442"/>
        <property type="gene ID" value="AFM11_10825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6204"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="281" mass="29491" checksum="DDD5F4D069BBEC21" modified="2016-06-08" version="1">MSGRVEGKVAFVTGAARGQGRSHAVRLAQEGADIIALDICGPVRPGVETAIPASTSDDLAETANLIKGLDRRVVTAEVDVRDADAVKAAVDSGVEQLGRLDIIVANAGIGNGGDVLHETSQLDWDEMIDINLSGVWKSVKAGVPHLIAGGRGGSIVLTSSVGGLKAYPHCGNYVAAKHGVVGLMRGFAVELGQHNIRVNTVHPTHVATPMLHNEGTFKMFRPDLENPGPDDMAPICQMFHTLPIPWVEAVDISNAVLFLASDEARYITGVTLPVDAGSCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR28</accession>
    <name>A0A132PR28_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mammalian cell entry protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_08980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846718.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13390"/>
    <dbReference type="EnsemblBacteria" id="KWX24779">
        <property type="protein sequence ID" value="KWX24779"/>
        <property type="gene ID" value="AFM11_08980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5646"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="574" mass="59976" checksum="30BD14D4CDE3C32A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRE7</accession>
    <name>A0A132PRE7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_05665</name>
        <name evidence="2" type="ORF">AWC31_13040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845062.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13040"/>
    <dbReference type="EnsemblBacteria" id="KWX24928">
        <property type="protein sequence ID" value="KWX24928"/>
        <property type="gene ID" value="AFM11_05665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18875">
        <property type="protein sequence ID" value="ORX18875"/>
        <property type="gene ID" value="AWC31_13040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4323"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX18875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="129" mass="13945" checksum="A3CA49B76F1A41B0" modified="2016-06-08" version="1">MADWGDVARIAADLPETGEPTPRTWRVRKKLVVWERPLRKADYAALGADAPDGDILGARVADEGVKFALIADNPAVYFTTPHFDGYPIVLVRLAAIGVDELTELITEAWLAQAPKTLVKAYLADAADSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRQ7</accession>
    <name>A0A132PRQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845261.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29370"/>
    <dbReference type="EnsemblBacteria" id="KWX25038">
        <property type="protein sequence ID" value="KWX25038"/>
        <property type="gene ID" value="AFM11_06305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4455"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="285"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="495" mass="52120" checksum="708E11BFAEAA527A" modified="2016-06-08" version="1">MPEFTIGVDIGTTGTKTVLVNVGEARIVAQASRDTRLHADAPGHAEADPAQWLDNVHIGIREVLAQSGVPPREVGALATTGMVPAVVPVDHAGSPVRRAMLQNDARATAEIEQLKAASDAEAVLAATGSAITQQSVAPTAMWLRRHEPETWNATTHLVGSYDWVLMALGATPHVELNWAIESGLGTVEGVRFDPMFEAADLKADLVPRVLAPGARAGALSRDAAEATGLPAGLPLIVGGADHVLSAYAAGVNTPGDWLVKLGGAGDILAASDSPVIDARLYLDAHPVPGRWLPNGCMATSGSLIRWFQTLSGGVDLIALDEEAASRAPAEVLCLPYFLGEKSPLHDPDLRGAFVGLDLAHTRADMYRSVLEAIAFGFKHHTEVFTSIGVPLQRALVTNGGSRSVLWKQILADVLDTPLSPIVGHPGASLGAAVVAAVGIGLLDDWDSTGPFRTLGDPVTPDRRNTDRYAQAYAEWRTLGDVLTPVSHRIARKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRR7</accession>
    <name>A0A132PRR7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_08700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846573.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13670"/>
    <dbReference type="EnsemblBacteria" id="KWX24732">
        <property type="protein sequence ID" value="KWX24732"/>
        <property type="gene ID" value="AFM11_08700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5590"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="UCP036654"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="PTHR43260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036654">
        <property type="entry name" value="UCP036654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="5"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="547" mass="59129" checksum="B286227FE73ECCF7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS45</accession>
    <name>A0A132PS45_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_07070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17645"/>
    <dbReference type="EnsemblBacteria" id="KWX25171">
        <property type="protein sequence ID" value="KWX25171"/>
        <property type="gene ID" value="AFM11_07070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4613"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453287" evidence="3">
        <location>
            <begin position="35"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="297" mass="28730" checksum="8DADA0F7423E277B" modified="2016-06-08" version="1">MSVDRTWMRNTAIGCAIACGAMVAGPGVAGTAVASADLFGIDLDILDIFDHKDKKKKSDHGAKVGAQQNGGSKKTGGPGNAGPKKAARPDPGGASQSAASADRAPESANAPESVTFGGAGQSPPAAVSGGGGGGGGVPTNSNIGRAPNLAPVPTTPSSRGIVIRATPPAAPAPVAPVAPAPVVLPPVPIALPPLPAAPSGGGAPSAPAVPSPNAPAVEPPSAPPLASNPSAPQVIPDSFRIGYADYLRTASTSDLLFAVLPGVAGLALLTAAGGAIGFRQARAAQTLPSPQIARFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS48</accession>
    <name>A0A132PS48_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_08690</name>
        <name evidence="3" type="ORF">AWC31_13680</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000005">
        <property type="protein sequence ID" value="ORX18573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846979.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13680"/>
    <dbReference type="EnsemblBacteria" id="KWX24852">
        <property type="protein sequence ID" value="KWX24852"/>
        <property type="gene ID" value="AFM11_08690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18573">
        <property type="protein sequence ID" value="ORX18573"/>
        <property type="gene ID" value="AWC31_13680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5588"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453538" evidence="1">
        <location>
            <begin position="24"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="220" mass="23686" checksum="7848BC3FA41A0DFD" modified="2016-06-08" version="1">MRLIWAMSLAALAWAAAPGLAWSEPIDCPPMCDRIPASAWIASSDVPLNREYRWPGLAGLAVTTTSPRFRFEEDCGLPLLPGDSREYAVTARAAVSQPEGQWQLQVQVMHWRGETWRGGETAMSAVSVAAGALRACQLTRPGSSPSITTDEPGRLAAVITFGGERVLRQYLLADPDNSTVVELAMWSTTPPAVAWPTVADSQVLDAMARPLCSAYVGSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS49</accession>
    <name>A0A132PS49_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845225.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29490"/>
    <dbReference type="EnsemblBacteria" id="KWX25017">
        <property type="protein sequence ID" value="KWX25017"/>
        <property type="gene ID" value="AFM11_06185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4429"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="261"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="519" mass="55211" checksum="E42057B4C6FF4D43" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSA3</accession>
    <name>A0A132PSA3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845765.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17330"/>
    <dbReference type="EnsemblBacteria" id="KWX25226">
        <property type="protein sequence ID" value="KWX25226"/>
        <property type="gene ID" value="AFM11_07390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4678"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023907">
        <property type="entry name" value="Non-F420_Flavin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03885">
        <property type="entry name" value="flavin_revert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="327" mass="36121" checksum="A6B24C41333D0589" modified="2016-06-08" version="1">MTVIGFHCSHEQISPAQLLLDVQHAEQAGFTAAMSSDHFSPWSERQGESGFAWSFLGAALATTHLPFGVVNAPGQRYHPAIVAQAIATLAQMFPGRFWAALGSGEASNERVTGEAWPRKEVRDQRLVECVDVIRRLLSGEEVSHDGHVHVNRARLWTLPDTVPDLVGPAVTPETAARHAAWADGLVTVNQSKDTLRKVLDAYREAGGRGPARLQIHLSWAPTEGQALAIAHDQWRSNVFSPPICWDLESVDAFDAVSEYVTPDQVKKSVNVSGDLGRHRQWLHEYIEQGWDELYLHFVGQQQRGFIDAFGENVLPEFSPTAPQEVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSL1</accession>
    <name>A0A132PSL1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose-6-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_03220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843895.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21875"/>
    <dbReference type="EnsemblBacteria" id="KWX25313">
        <property type="protein sequence ID" value="KWX25313"/>
        <property type="gene ID" value="AFM11_03220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2519"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="155" mass="17268" checksum="0C34F55E2789CFB8" modified="2016-06-08" version="1">MNDHAHDFFGDIFQRYFRPAVDEYPGMGAALVHRLMTSTDDVQDRLAEARHAALAWSREERSPAGITSELFVITQCGLMYAAGFGDSRHRHYYLATPAALFDPFVDQVEGVQLHPGEVVAVDRRCCNDLAAAHPMDAALSRILDEHEALRVNVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSS6</accession>
    <name>A0A132PSS6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_06575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845345.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29100"/>
    <dbReference type="EnsemblBacteria" id="KWX25082">
        <property type="protein sequence ID" value="KWX25082"/>
        <property type="gene ID" value="AFM11_06575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4510"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="247" mass="25829" checksum="E7C645D660F452C9" modified="2016-06-08" version="1">MKAVVSTLRTVRAAVITTASQLSTRRILALLAGIVILVAVALLVPLPTAMQLRDWATSVGPWFPLAFLGAHIVVTVFPFPRTAFTLAAGLLFGPATGVALAVVASTVSAVLALLLIRAAGLQLNRLVSHPRVESLDARLRQRGWPVVLSTRMIPAVPFSVLNYAAGASAVRVVPYTLATVVGLLPGTAAVVILGDALTGNVSPMLFVVSLCTAALGVAGLVFEVRSHRREQRKNRAADAPAEEAFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSU1</accession>
    <name>A0A132PSU1_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_03895</name>
        <name evidence="10" type="ORF">AWC31_21270</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844253.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21270"/>
    <dbReference type="EnsemblBacteria" id="KWX25416">
        <property type="protein sequence ID" value="KWX25416"/>
        <property type="gene ID" value="AFM11_03895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16561">
        <property type="protein sequence ID" value="ORX16561"/>
        <property type="gene ID" value="AWC31_21270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2657"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="185"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX25416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX16561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="417" mass="43741" checksum="EF5971E93EC44488" modified="2016-06-08" version="1">MRSVEEQQARVAAAAVAPRPVRVAIAESQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVLGVGDADSEDGSGEISLPVMGAIEAGARTPSRLQPRQAARVQTGAPMPTLADAVLPLRWTDGGQNRVRVLRGVRSGAYVRRTGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRDRVLVHPRPRLSVMCVGGELVDVSRTPGTGQVYDVNSYALAAAGRDAGAEVNRVGIISTDPGELRETVEGQVNRNEIVVIAGAVGGAAAESVRTVLSELGDMEVTRIAMHPGSVQGFGQLGRDRVPVFLLPANPVSALVVFEVMVRPLIRLSLGKRQPMRRIVQARTLAPISSVPGRKGYLRGQLMRDQDTGEYLVQALGGAPGASTHLLATLAEANCLVVVPSEVEEVRTGETVDVAFLAQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSZ6</accession>
    <name>A0A132PSZ6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="4" type="ORF">AFM11_06960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845516.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28690"/>
    <dbReference type="EnsemblBacteria" id="KWX25152">
        <property type="protein sequence ID" value="KWX25152"/>
        <property type="gene ID" value="AFM11_06960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4591"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="538"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="799" mass="84545" checksum="D0BE43E40AA066F5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTD0</accession>
    <name>A0A132PTD0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844650.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20295"/>
    <dbReference type="EnsemblBacteria" id="KWX25570">
        <property type="protein sequence ID" value="KWX25570"/>
        <property type="gene ID" value="AFM11_04850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2851"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="135" mass="13706" checksum="EC71918D90FCA4DA" modified="2016-06-08" version="1">MTAIVTPPLSDSTDSLLRFALRADATLCAGVGLLVAMAADPLARVSGLSATAGWIAGAALVGYGALLYVLAALPDIRKVGVAVVIGNVAFAVTTVTAIVADWLPLSEIGADLVLSFVAATAALAWLQYRGVRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTK2</accession>
    <name>A0A132PTK2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_03440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21710"/>
    <dbReference type="EnsemblBacteria" id="KWX25668">
        <property type="protein sequence ID" value="KWX25668"/>
        <property type="gene ID" value="AFM11_03440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2562"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453582" evidence="1">
        <location>
            <begin position="33"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="255" mass="24739" checksum="3A4CC7C02CA547B9" modified="2016-06-08" version="1">MPPTPAQPPVRAPRRALLVTACLVAGAVAGAGAGLMAGGADVATVIRQQPPAAAGSSAVPDAQAAAAALLPSVVDIRAGNSRGSGFVIDDQGRVMTNNHVVQGYSRVSVAYADGRESAARVVGTDPATDIAVLEVAGSAPAAAALGTSSALRIGQPVIAVGAPLGLSSSVTAGIVSATDRTARLGGQPALPMVQTDASINPGNSGGPLANLQGQVIGVNTALATVGGAEAGNIGIGFAVPIDRAIDVARQIIAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTM8</accession>
    <name>A0A132PTM8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20820"/>
    <dbReference type="EnsemblBacteria" id="KWX25699">
        <property type="protein sequence ID" value="KWX25699"/>
        <property type="gene ID" value="AFM11_04350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2747"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="95" mass="10548" checksum="009D59647CE79190" modified="2016-06-08" version="1">MWAPRLPYMAVIEHTGRKSGKSFRTPVMAFVGDGTVSVVLNYGTQSDWVRNVQAASWAGVVHRGKHYRLTEPRILPGESPHQKARLVATLAPPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU19</accession>
    <name>A0A132PU19_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_00235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842136.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33345"/>
    <dbReference type="EnsemblBacteria" id="KWX25764">
        <property type="protein sequence ID" value="KWX25764"/>
        <property type="gene ID" value="AFM11_00235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.48"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="156" mass="17023" checksum="BB7ECC08934EA85A" modified="2016-06-08" version="1">MQQSTTYRAWQQLSGKPLGTRLFSAAAMARVPYFASIVPHVVRMEPGLAEVKVPKWFFIYNHLHTVHAIASCNAAEMAMGMLMEATVPTTHRWIPKAMNVSYLAKATTSLRATATLSAPDFSTITEGADIVVPVSVTDRHGAEVVHADITTWVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU23</accession>
    <name>A0A132PU23_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_00545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842296.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33660"/>
    <dbReference type="EnsemblBacteria" id="KWX25820">
        <property type="protein sequence ID" value="KWX25820"/>
        <property type="gene ID" value="AFM11_00545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.112"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="22"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX25820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="37274" checksum="B61DF8E56D7F2BE2" modified="2016-06-08" version="1">MASPRGALLDAVSALPQAVNPLALSLNECPFPPLPAVRSALSTSNDAVNRYPEFLPERLRSLIAGHDGIGEDQVVIGVGATGVIMQVLHAVTSPGDTMVMSSPTFDGYPIFAQMARLRSVTVPLDRHGHHDLDAMAEAATHARVVVVCRPHNPTGTVEPAADIERFLARVPADTVVLLDEAYVEFLAAEHRIDGPSLVTRFGNVVVVRTFSKAYGLAGLRIGYGFCAPELGRQLWTMQLPFGIGLTAMVAVAASYDAESQLRQRIRMIAAERRYLQMRLRALGVYTTDGQANFIYLPADHAPWREVFDGTGLQVRHYVDGGVRITIGSRQSTRAVLWAVRAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU57</accession>
    <name>A0A132PU57_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Type VII secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFM11_00875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842465.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33910"/>
    <dbReference type="EnsemblBacteria" id="KWX25879">
        <property type="protein sequence ID" value="KWX25879"/>
        <property type="gene ID" value="AFM11_00875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.181"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KWX25879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="468" mass="48449" checksum="46017F744B83F2B1" modified="2016-06-08" version="1">MARQPATRLQLSGHRFLLRRTAHALVRGDARMLDDPLRAQAIAFTAGGVLAVVAITACAVLALVRPGGELADAPILLARNSGALYVRIGDTIHPVPNLASARLVVGAAADPVPVSDDALARARRGPQVGIPGAPTQIDSPLSIDESAWAVCDIAEPVSTTLVVGALSDRVAPLRHGQALLVAPRGEPAATTYLLFDGWRAAVDLRDLAVTRALRLDGLKPTGVSRALLDSVPEAPAIRAPAIAGAGLPGPAALRGVDVGSVVRVRRAGDTDEFYVVLAGGVQRVGRVAADLIRFTVAQPAAEPPVVSAQAIARVPVVEDLAVARVPQWVDAHARPVLCAGWDPRQPSAETNTTLYAGDSLPETGLRLAQADEAGPAIDRVDIPAGRSALVRATGIDGGIGVAGPRYLLNDLGVLFGIHDDTAAEHLGLTRPAVLAPWPMLAMLPRGPELSRDAASVAHDGLTSRGWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUD3</accession>
    <name>A0A132PUD3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842744.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25958">
        <property type="protein sequence ID" value="KWX25958"/>
        <property type="gene ID" value="AFM11_01385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.284"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="31"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="148" mass="16155" checksum="FB9A72733EE0EAE3" modified="2016-06-08" version="1">MSDGPVGAEREATEILHRFYAAETAYLQSEPKDFSAMAAVLHPDCVMHQPSSLPYGGSWQGHDGFRRWMAAFGAVWSTLVVADPTLLVSGADVIFVRSTVHATARTSGAELSWPLLQMVTVRDGLILEMRPFYWDTAAIVEALGTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUI6</accession>
    <name>A0A132PUI6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzene 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842873.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25996">
        <property type="protein sequence ID" value="KWX25996"/>
        <property type="gene ID" value="AFM11_01680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.346"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00667">
        <property type="entry name" value="ring_hydroxylating_dioxygenases_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000391">
        <property type="entry name" value="Rng_hydr_dOase-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41534">
        <property type="entry name" value="PTHR41534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00866">
        <property type="entry name" value="Ring_hydroxyl_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="188" mass="22202" checksum="E6CF8B3818547C8F" modified="2016-06-08" version="1">MSVGEMIQPTGVADLEQVLLQHRVEQFLYREAQLLDHWQWASWLELFAEDVLYWMPVRRNRLRRQRGQDEVPDGIEMAHFYDDFSSLQMRVNQMHSGTHWAEDPPSRCRHLVTNVILRPRSESTGQAVEYDVWSNFLVYRNRLESETDIWAGERRDVLRGTATGFKIARRTILLDQNVVQSKNLSVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUN9</accession>
    <name>A0A132PUN9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="12" type="ORF">AFM11_02165</name>
        <name evidence="13" type="ORF">AWC31_34945</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000030">
        <property type="protein sequence ID" value="ORX11846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843104.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34945"/>
    <dbReference type="EnsemblBacteria" id="KWX26069">
        <property type="protein sequence ID" value="KWX26069"/>
        <property type="gene ID" value="AFM11_02165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX11846">
        <property type="protein sequence ID" value="ORX11846"/>
        <property type="gene ID" value="AWC31_34945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.444"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="129"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX26069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX11846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="207" mass="22055" checksum="AB01B6D31442F63C" modified="2016-06-08" version="1">MDVRVVDHPLAAARLTTLRDERTDNAAFRAALRDLTLMLVYEATRDAACEQIPVRTPLVETTGSRLANPPLLVPVLRAGLGMVDQAHALIPEAQVGFVGVARNEETHQPTPYLASLPDDLSSRSVFVLDPMLATGGSMAHTIGLLRERNAVDITAVCVVCAPEGIAALEAVAPDMRLITATVDEGLNEIAYIVPGLGDAGDRQFGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV70</accession>
    <name>A0A132PV70_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_01400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34370"/>
    <dbReference type="EnsemblBacteria" id="KWX26241">
        <property type="protein sequence ID" value="KWX26241"/>
        <property type="gene ID" value="AFM11_01400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.287"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S53" evidence="4">
        <location>
            <begin position="149"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX26241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="517" mass="54129" checksum="6417025451233E8C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAP9</accession>
    <name>A0A132PAP9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_36010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000067">
        <property type="protein sequence ID" value="KWX19411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19411">
        <property type="protein sequence ID" value="KWX19411"/>
        <property type="gene ID" value="AFM11_36010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="13"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="234" mass="25642" checksum="BC69028BB95E82EB" modified="2016-06-08" version="1" fragment="single">MWEAPVIRQRTSVGLDVHARSVFGCGFDAETGQVLERRLTPDHGEIIAWIRSLPPPVMVAYEAGPTGFGLARALTAAGIEVVVAAPSKLQRPAGDRVKTDARDARHLARLVHLGEVVGVQVPSPEREAARDLVRAREDCRGDLMAARLRLSHMLLRHGIVYYGGNAWTGKHELWLRAQRFTTPGLQDAYDSAFDAMLANADRRDRLDAAITQMAADSEFTPVVTRLGCIRGIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAV3</accession>
    <name>A0A132PAV3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35710</name>
        <name evidence="3" type="ORF">AWC31_12670</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000047">
        <property type="protein sequence ID" value="KWX19461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000004">
        <property type="protein sequence ID" value="ORX18909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859938.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12670"/>
    <dbReference type="EnsemblBacteria" id="KWX19461">
        <property type="protein sequence ID" value="KWX19461"/>
        <property type="gene ID" value="AFM11_35710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX18909">
        <property type="protein sequence ID" value="ORX18909"/>
        <property type="gene ID" value="AWC31_12670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5878"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013434">
        <property type="entry name" value="CHP02611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019099">
        <property type="entry name" value="Uncharacterised_PGPGW_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09656">
        <property type="entry name" value="PGPGW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02611">
        <property type="entry name" value="TIGR02611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX18909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="139" mass="15413" checksum="C8BC77369CF0369E" modified="2016-06-08" version="1">MNISEAKRAWASWRDRLRERRMVNFAYRIVVGVVGTVVLCAGIIAIPYPGPGWAIVFLGLAILATEFRFAQVALHHVRLRYDAVMEWFGRQHIAVKALSAAFTALVVVVSLWGLGALYFMGDLVGFEPPWLKSPLGIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB96</accession>
    <name>A0A132PB96_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_34895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000040">
        <property type="protein sequence ID" value="KWX19586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859536.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02130"/>
    <dbReference type="EnsemblBacteria" id="KWX19586">
        <property type="protein sequence ID" value="KWX19586"/>
        <property type="gene ID" value="AFM11_34895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5708"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX19586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="443" mass="46557" checksum="A5F8720532D8C58F" modified="2016-06-08" version="1">MALLVAGALFMEILDATIITPAIPLIASSFGVDAVDVNVAISAYLVTVAVLIPASGWMADRFGIRRVFIAAIAVFTLASVGCALSASLPMLVGMRVLQGVGGAMMVPVGRLAVLRYSDKSDLVRAIALLTWPALAAPILAPVLGGAIATLGSWRWIFAVNIPIGLIGFLLALRLIRGDPAATSRSLDWPGLLALGSGIAAALIALENVRVSGTDWLLVGLCWVGAVVLLSAAVWRLLRAQNPLVQLRVLKVRTLRITVQAGSLYRMVITAVPFLLPLQFQLEFGWTPFAAGLMVAALFAGNLTIKPLTTPMMRRIGIRNVLLMNGIASVGCFGLLAMLQPGMPVTVMAVVLYVSGALRSIGFTAYNSLAFSDVDGDQLTHANTLNASVQELAAGLGIAISALLLSQLTSYSATFLVLGAFLAFTLIETLRLPRNAGAHVSGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBG8</accession>
    <name>A0A132PBG8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allantoicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_34635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000038">
        <property type="protein sequence ID" value="KWX19673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859374.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22205"/>
    <dbReference type="EnsemblBacteria" id="KWX19673">
        <property type="protein sequence ID" value="KWX19673"/>
        <property type="gene ID" value="AFM11_34635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5274"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="64"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="455" mass="49020" checksum="59784D46311FEAED" modified="2016-06-08" version="1">MTADAPEQSNRPDYDLVVRGERTLTTAGIVAREIGIRDGRVVAIEPLGSGLTGAEIIQLTDEQVMIPGLVDTHVHVNEPGRTEWEGFDSATRAAAAGGVTTLIDMPLNSIPPTVNVEALNAKRAAASGKTHIDVGFWGGAIPGNTGDLRALHDDGVFGFKCFLLHSGVDEFPHLDADEMEKDMAVLAGFDSMMIVHAEDSRAIDRAPSAEGDRYERFLASRPRGAENVAIAEVIERARWTGVRAHILHLSSSDALPMLATAKRDGVKITVETCPHYLTLLAEEIPNGATAFKCCPPIREASNRELLWQGLLDGTIDCIVSDHSPSTVDLKDVENGDFGVAWGGVASLQLGLSLIWTEAKRRGIPLTQVLEWMAAKPAELAGLNNKGKIALGYDADFAIFEPESAQVVDVHKLHHKNPISPYDGRALAGVVTGTWLRGKKIDFKTPQGRMLRRGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBX4</accession>
    <name>A0A132PBX4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_33815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HipA Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000035">
        <property type="protein sequence ID" value="KWX19833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858891.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19833">
        <property type="protein sequence ID" value="KWX19833"/>
        <property type="gene ID" value="AFM11_33815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5099"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012893">
        <property type="entry name" value="HipA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017508">
        <property type="entry name" value="HipA_N1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13657">
        <property type="entry name" value="Couple_hipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07804">
        <property type="entry name" value="HipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03071">
        <property type="entry name" value="couple_hipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Couple_hipA" evidence="4">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HipA_C" evidence="3">
        <location>
            <begin position="157"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="408" mass="44458" checksum="454D35A9176BF72D" modified="2016-06-08" version="1">MMDRIGLDLREVTKADVYIGDVLAGHLTRERGDDVSFDYVAEESGEGRVRDRSVSWSLLRSGEYPVITTGGAVPPFFAGLLPEGVRLGVVTSSTKTSADDHLTLLLAIGADTVGDIRVFPAGAAPLLPLPLFEPERDNDFHAVFAKLTGSVEADPVGLAGVQPKVSAAMMSTPTQTRAGPAILKLNPAGFPLLVENEHFFMRMASACGLRTAQTTLLRDRHGHSALLVSRFDRLGPRRIPQEDACQVADLYPASKYRIKTETALTKLADACGRGGGSRVIALVELLKVVVFSWLIGNGDLHGKNMSIYNPDGLWQPTPAYDLLCTQPYTGWNDPMALSLYGRANRLTRSNFIEAGERLGIRQRATNNIIDAMIEAATAWPDRCGEIGFDDRQTERLAQLLRTRLDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC28</accession>
    <name>A0A132PC28_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_33385</name>
        <name evidence="7" type="ORF">AWC31_02330</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858672.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02330"/>
    <dbReference type="EnsemblBacteria" id="KWX19876">
        <property type="protein sequence ID" value="KWX19876"/>
        <property type="gene ID" value="AFM11_33385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13376">
        <property type="protein sequence ID" value="ORX13376"/>
        <property type="gene ID" value="AWC31_02330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5009"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX13376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="214" mass="23427" checksum="A3950BA75A8319CE" modified="2016-06-08" version="1">MYLSEPHDQEPPELTSTTTPRSVRDRLIDAAEVCLRTKGIRATTVSEVAEAAGVSRGWLYRHFPDKVTLLGAAIVRLNEAYWSEAHAMLEQFDGLDQKIAAGIRHGRTAYDDPGALLMKLRVEEPDEFAACAGAGVQGLVPDLAEFWSRYLVAARDAGEIHPDTDIAEASEWVARVLLTFATVPGEQLDAGDFDAVLTHLRRYVMPGLKADPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC46</accession>
    <name>A0A132PC46_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_33515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858742.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02235"/>
    <dbReference type="EnsemblBacteria" id="KWX19900">
        <property type="protein sequence ID" value="KWX19900"/>
        <property type="gene ID" value="AFM11_33515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5036"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="223" mass="25760" checksum="2D95CBD160488308" modified="2016-06-08" version="1">MAATPLPPIVSRTEWEEQRAKLLVREKELTRMKDAVSAARRRLPMVEITENYVFDTESGPLSLLDLFDGRRQLIVQHFMFGPDWDQGCDGCSMMADHIGPLSHLHAKDTSFVLVSRAPMGKLLAFRDRMGWALPWVSSGATTFNEDFHVTVDGEERHAISVFLRDGARVFHTWSTYNRGEEPFMVVFDLLDLTPYGRQETWEDSPKGWPQQPPYEWMRLHDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCJ3</accession>
    <name>A0A132PCJ3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_34215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000037">
        <property type="protein sequence ID" value="KWX19702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859140.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19702">
        <property type="protein sequence ID" value="KWX19702"/>
        <property type="gene ID" value="AFM11_34215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5181"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="173" mass="19234" checksum="B14943B7E6343D8A" modified="2016-06-08" version="1">MSHSPSGRCDAELIDGAVITIRPLTSGDSGRVVTLYQSLTDEERYLRFFTVYPAHLRRWACSLTEQSADQYAIGAFASKELLGVANYVRCSERDHAEAAVVVAHDEQFRGIGTALLNQLGKIAKRSGIRYFVAEVLTENQSMMHVISESGWPCSRRRDGSVLHIELDLDDVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCP3</accession>
    <name>A0A132PCP3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_32540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858132.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19675"/>
    <dbReference type="EnsemblBacteria" id="KWX20086">
        <property type="protein sequence ID" value="KWX20086"/>
        <property type="gene ID" value="AFM11_32540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4836"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="203" mass="21036" checksum="A0B537C94A8E4EE8" modified="2016-06-08" version="1">MTQLLVASRNPKKLAELRRVLDAAGVSGLELLSLADVAPFDEAPETGATFEENAEAKARDGYVATGIACVADDSGISVDALNGMPGVLSARWSGVHGDDAANTRLLLAQLSDVPSERRGAAFVSACALVSASGSVVVRGEWPGTVTREPRGDGGFGYDPVFLPEGSTRTAAELTPAEKDAASHRGRALALLVPALRELAARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCT4</accession>
    <name>A0A132PCT4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_31915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857793.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20151">
        <property type="protein sequence ID" value="KWX20151"/>
        <property type="gene ID" value="AFM11_31915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4709"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="377" mass="41127" checksum="F6F95CB654A87CDB" modified="2016-06-08" version="1">MLEITNLVKTFDGDKQPNTKDAARVRAIDDVSIHVKEGELFTLLGPSGCGKTTTLRSVAGLERPDSGTIKVADRVMFNSTGAKAFHMPTNERGLGMVFQSYAIWPHMKVFDNVAFPLQVLPRRKRPSKKTIAEKVERVLATMELAHLAGRQATKLSGGQQQRLALARALVTEPPLLLLDEPLSNLDAKLRESLRFELKRLQHDLGITSIYVTHDQIEALALSSRIAVMRSGKIMQLAPPRDIYERPANRFVAEFIGTSNFVNGTVTGREDNHLVVETGHGRLMVASELSIGIGESVILAARPEAVTLIDEPPTVSGPNQLTGSIVTRSFLGDAVDHIVRVGDQDIRARCEPSVSYAPETKVTLHVAPASLTLVPIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD11</accession>
    <name>A0A132PD11_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel protein MscS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_31260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857420.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25410"/>
    <dbReference type="EnsemblBacteria" id="KWX20223">
        <property type="protein sequence ID" value="KWX20223"/>
        <property type="gene ID" value="AFM11_31260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4157"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX20223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="335" mass="36163" checksum="E43D960B47002BFC" modified="2016-06-08" version="1">MTINTLASNWAATTLAFPMAERWHDFWHGEIGAWILTKGLRIALLLIGALLAARFINWAAQRVVRRIDAEYEESDQLVRSESAKHRQALASVISWVSVALLFVIVLVEVTDVLAVPIASLVAPAAVLGAALGFGAQRIVQDLLAGFFIITEKQYGFGDLVRLTIGAANEAEGTVEDVTLRVTKLRSSEGEMYTVPNGQIVKALNLSKDWARSVVDIPVPVGADLNLVNDVLNEVAEKAAEDRELSKLVLDKPQLMGVESIGVDTVNLRMVARTLPGKQFEVGRRLRVRVVRALRRAGIVTASDGSVAAAGDIVHPVAVAEVQKAAPPAASEEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD33</accession>
    <name>A0A132PD33_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prmC</name>
        <name evidence="9" type="ORF">AFM11_33365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858659.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02350"/>
    <dbReference type="EnsemblBacteria" id="KWX19872">
        <property type="protein sequence ID" value="KWX19872"/>
        <property type="gene ID" value="AFM11_33365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5005"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="115"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="189"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX19872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="285" mass="29811" checksum="DF3E72EEECAA07C0" modified="2016-06-08" version="1">MTSMRQAIEAATATLEAAGVGSPRIDAELLAAHAAGTDRGRLILLDDPGPDVLQTFHDLVAARSRRVPLQHLIGTAAFGPLTLAVGPGVFIPRPETESLLEWAVNWVDAHDLPRGAVIVDLCTGSGALALALARHRPDARVIAVDDSPAALEYARRNTAGTTVEVLAADVTAPGLLPELDGAVDLVVSNPPYIPDEAELEPEVADHDPAHALFGGPDGMAVIGPLVRLAARWLRDGGACAVEHDDTTSHRTVAAFADDGSFGDVTAHRDLAGRPRFVTATRIGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD46</accession>
    <name>A0A132PD46_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_31345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857459.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25500"/>
    <dbReference type="EnsemblBacteria" id="KWX20236">
        <property type="protein sequence ID" value="KWX20236"/>
        <property type="gene ID" value="AFM11_31345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4175"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="319" mass="33422" checksum="994E0189F7A3E9CF" modified="2016-06-08" version="1">MPTPPQRPGQPGWRGQGRPPSDPATRRLPRAGRPEPPTEQLRARYRPPDAATEKIARPRPPEAATEKLTRPAASSLRGGQRRNRQTIILVVVIALAAVVGGLAAAELYARHRAGNLLVAVAECVVQDSASVSFGVNPPFLWQHITGHYTNISVDTGGARVQAAEGMTADVTLEDIRLQGTADSKGTIGSLNATLAWTAAGIKDTVAANLPGVGSLVTGVSTDPAAGTISLEAAGDTRITAQPVVAEGDLNLQVLDVTGPFSKETVQTALNELTTKLNDNYPLGIHADSVAVTESGVVGKFSSQDAQIPNDDSEPCFERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD57</accession>
    <name>A0A132PD57_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857602.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26235"/>
    <dbReference type="EnsemblBacteria" id="KWX20281">
        <property type="protein sequence ID" value="KWX20281"/>
        <property type="gene ID" value="AFM11_31620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4228"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="33"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="316" mass="33007" checksum="5128E95A8E7E4930" modified="2016-06-08" version="1">MKPDDLTFYSEGEQCSAWHFPGVGDGFAGAAGRPVVVMAHGFGGTKDSGLQPFAERFSAAGLDVLAFDYRGFGASEGSPRQSVSVDRQLADYAAAVSAAQRLPGVDAARVVLSGSSFSGSHVLRTAARCNDVAGVIAMTPLTSGLAASRAAVAHRDVGSALRWTLVGLKSRVAVARGGAPTLMPLAAPPGEPGALALDGAYESYLSIAGPTWRNEVDAGIGMELIRIRTAAAAKSLKCPVLVQIADFDRFVPADSVVKTAVQARAQVHHYPCDHFDVWPGHDWFDTAVEDQLRFLTRSLAGASRRVGTQIAADAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD78</accession>
    <name>A0A132PD78_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_31615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857599.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26230"/>
    <dbReference type="EnsemblBacteria" id="KWX20280">
        <property type="protein sequence ID" value="KWX20280"/>
        <property type="gene ID" value="AFM11_31615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4227"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="442" mass="49053" checksum="E8C1F5347409D407" modified="2016-06-08" version="1">MSQQSPPRTAIIGAGISGLTAGKMLKDYRVPYTTFENSDRIGGNWAFGNPNGHSSAYRSLHIDTSKHRLSFKDFPMPEHYPSFPHHSDIKAYLDAYADAFGLLDNIEFNNGVVHVSRADGGGWEIEDQAGARRRFDLLVVANGHHWDPRLPDFPGTFTGQTIHSHHYIDPTSPLELTGKRILIVGIGNSAADITVELSSKALQNQVTLSTRSSAWIVPKYIAGQPGDKFFRTTPYLPLSWQRKAAQLIAPMLGTDPTAYGLPAPNHKLFEAHPTQSVELPLRLGSGDVTPKPNVTRLDGDTVHFEDGTSGVFDAIVYATGYNITFPFFDPDVVSAPDNHIRLYKRMFKPGIEDLVFIGFAQAIPTLFPFVECQSRLLAAYAVGRYALPSVAEMERVIDADQQLHAGHCTDRPRHTQQVDYFYYEHDIQKRELPAGARRAKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDL1</accession>
    <name>A0A132PDL1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_31225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857363.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26935"/>
    <dbReference type="EnsemblBacteria" id="KWX20418">
        <property type="protein sequence ID" value="KWX20418"/>
        <property type="gene ID" value="AFM11_31225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4150"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="106" mass="11929" checksum="31D7C5AB52FF084A" modified="2016-06-08" version="1">MTAVDERAPLFDALGDPNRLRIVTRLCDGGPCSTAQLTEVIAVSRQAATKHLLLMEAVGLVSSHRQGRERIWEIRPEPLAEASDYLTALSRRWDRAIDRLRAYVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDL6</accession>
    <name>A0A132PDL6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_30705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857095.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26425"/>
    <dbReference type="EnsemblBacteria" id="KWX20327">
        <property type="protein sequence ID" value="KWX20327"/>
        <property type="gene ID" value="AFM11_30705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4043"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="406" mass="45917" checksum="94EDA2B901B48981" modified="2016-06-08" version="1">MESQVQDSPKESVREAADNLLRDPYPIFARHRAEHGVFRGSVMDWSKTPASMLPEHQYAAVSFDAVNTVFRDGKTFNSKIYDSTIGLFIGPSILAMEGKTHRDHRNLVSAAFKARSLQRWEPEIVRPICEALVDEFISAGSADLVRDYTFEFPTRVISKLLGLPEEDLPWFRQRAVELISYTVKYKRAFEASAALKDYFLTQIELRRSKPTDDIIGDLVTAEIDGEKLTDEAIYSFLRLLLPAGLETTYRSSGNLLYLLLTHPEQFTAVQNDHELIGQAIEEGLRYETPLTTVQRSANQDTVLEGVELPAGAVIDVCIGSANRDEKRWERAEEFDIFRKRVPHITFAAGEHTCMGLHLARMETRVAMESLLNRVTDIRLVTDDDPHIFGQPFRSPTAIPVTFEPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDZ2</accession>
    <name>A0A132PDZ2_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sigma70_r4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_30145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000027">
        <property type="protein sequence ID" value="KWX20447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856774.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20447">
        <property type="protein sequence ID" value="KWX20447"/>
        <property type="gene ID" value="AFM11_30145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3924"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4" evidence="1">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="358" mass="40146" checksum="9FF0568FD200C48F" modified="2016-06-08" version="1">MACRQPLSPPPLVHPSDVDPFCVWLDELACDVAPVHELVSSMIRRYSRDGYERSILTARFGLEGQDRATLQEIGDQHGISRERVRQLVDRSVMRVAGRALKSAEDIDARDSLTERYGPAADVEALVRRLTLEACATETGSLTKSFAVLKLRLTGHRVADTKQLANEVRSRVVRVRNRLRELERVERKAVVADGYATSHLQRWLSHVEWPADTTMSPRPIPGHATRRIDVDEEGHGATFLDKLGREAAWDSRFESRLLRILNDSSLVETFQEQPVRVPYQWGGHARSYYPDVVAQLRDGRTVLIEAKPIYEVGYAVNQDKFAAGRGFAHSQGWGWLVWTDRYGIRPAITAITADGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE17</accession>
    <name>A0A132PE17_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_29705</name>
        <name evidence="10" type="ORF">AWC31_25045</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000015">
        <property type="protein sequence ID" value="ORX14469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856516.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25045"/>
    <dbReference type="EnsemblBacteria" id="KWX20579">
        <property type="protein sequence ID" value="KWX20579"/>
        <property type="gene ID" value="AFM11_29705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX14469">
        <property type="protein sequence ID" value="ORX14469"/>
        <property type="gene ID" value="AWC31_25045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3833"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="27"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="141"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="243"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX20579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX14469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="397" mass="42979" checksum="47E98882ED34D296" modified="2016-06-08" version="1">MTATTAPAKKATYAPLELFDTDRLLDEDERDIAATVRKFVDTQLKPNVEQWFESATLPKELGKEFGKLGVLGMHLEGYGCAGTNAVSYGLACMELEAGDSGFRSFVSVQGSLSMFSIHRYGSEEQKNEWLPRLATGDAIGCFGLTEPDFGSNPAGMRTRARRDGSDWVLNGTKMWITNGNLADVATVWAQTDDGIRGFLVPTDTPGFTANEIHRKLSLRASVTSELVLDNVRLPASAQLPLAEGLSAPLSCLNEARFGIVFGSLGAARDSLETAIAYAQSREVFDRPLSSFQLSQEKLANMTVELGKGMLLAIHLGRIKDAEGVRPEQVSLGKLNNVREALAIARECRTLLGGSGITLEYSPLRHANNLESVLTYEGTSEMHLLSIGKALTGQAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEI3</accession>
    <name>A0A132PEI3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_29435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040994.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20731">
        <property type="protein sequence ID" value="KWX20731"/>
        <property type="gene ID" value="AFM11_29435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="342"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX20731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="651" mass="71631" checksum="CEF344460EAEBEB3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEJ9</accession>
    <name>A0A132PEJ9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_29315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000025">
        <property type="protein sequence ID" value="KWX20714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_047040635.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20714">
        <property type="protein sequence ID" value="KWX20714"/>
        <property type="gene ID" value="AFM11_29315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3751"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="270" mass="27849" checksum="24D0CD20B4907591" modified="2016-06-08" version="1">MSEPEVLFDRPRPGVAVLTLNRPGARNSLGWQTWHQLGEAIDEVAADDNCRAVVLTGAGGTFSAGGDVKTSPARGAGLGAPAARLLVGQRVLDTLLKLPKPVLAAVEGPAVGAGWSLALACDLVVAARDAVFAAPFVARGLVPDCGAAWFLTRALGRHRAAALLLSGERLTAPQAAGAGLVSQLAEPGAALTVATDLAATLARGPAEALRLTKGMIRGALDVPLERFLELEWLSATLDLTGPDAAEGRAAFVEKRDPDFSKIRRSADEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEP8</accession>
    <name>A0A132PEP8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_28670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000024">
        <property type="protein sequence ID" value="KWX20805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856217.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32900"/>
    <dbReference type="EnsemblBacteria" id="KWX20805">
        <property type="protein sequence ID" value="KWX20805"/>
        <property type="gene ID" value="AFM11_28670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3615"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="236" mass="23896" checksum="02E7AB674580B176" modified="2016-06-08" version="1">MSSLVSYALNGSVATVTLDDGKVNALSPAMQTDINAALDQAAQAAGSGEVKALVLAGNSRVFSGGFDLSVFASGDTESALGMLAGGFELAVRCLTFPVPVIMAATGPAIAMGSFLLLSGDHRVGSPKSRCQANEVAIGMTLPVAAIEIMRMRLTRAAFQRGISMAATFAGDAAIAGGWLDEIVEQGDVLTRAQEVAAEAAATLHTTAHVASKLKARADAVTAIRAGIDGLATEFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PEU9</accession>
    <name>A0A132PEU9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFM11_27605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000023">
        <property type="protein sequence ID" value="KWX20869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10135"/>
    <dbReference type="EnsemblBacteria" id="KWX20869">
        <property type="protein sequence ID" value="KWX20869"/>
        <property type="gene ID" value="AFM11_27605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3395"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="149"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX20869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="361" mass="39262" checksum="7A389070DC696BFB" modified="2016-06-08" version="1">MSLRLKLTLSYAGFLMLAGALLLAAVWVFLLRYVPDRMMIIPGSTDIEFPNDVFPIRSRLLHVFAPRAAAVMAFLLVFGLVGGWLLAGRMLAPLTRITAATRLASKGSLSHRIRLPGRKDELRELADAFDTMLERLEAHVAEQQRFAANASHELRTPLAITQTLLDVARQDRTRDTGELIERLHVVNTRAIDLTEALLLLSRADQRSFAREPVDVSLIAEEAAETLLPLAERHGVTLEISADFAPTTGSPALLLQLATNLLHNAIVHNLPQSGTAWVRTGVRANSVVLTVENTGEKLSPQLVSTLVEPFQRGAERIHADHDGVGLGLAIVNSIAQAHDGTLTLEPRPAGGLCITVELPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFB8</accession>
    <name>A0A132PFB8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_27005</name>
        <name evidence="6" type="ORF">AWC31_06855</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855259.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06855"/>
    <dbReference type="EnsemblBacteria" id="KWX21038">
        <property type="protein sequence ID" value="KWX21038"/>
        <property type="gene ID" value="AFM11_27005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09918">
        <property type="protein sequence ID" value="ORX09918"/>
        <property type="gene ID" value="AWC31_06855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3275"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX09918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="153" mass="16741" checksum="F731EE7D4C827F9C" modified="2016-06-08" version="1">MLAVGSSAPDFTLRDQNGRPVTLSGYRGSKDVLLVFFPLAFTGVCEGELGEIRDNLPDYENDDSAVVAISVGPPPTHRIWSIESGFTFPVLSDFWPHGAVTQAYGVFNDDAGYPNRGTFVVDRTGIIRFAEMMDPGQVRDQKVWTQALAALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFG0</accession>
    <name>A0A132PFG0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Darcynin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27180</name>
        <name evidence="3" type="ORF">AWC31_07030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the darcynin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855328.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21061">
        <property type="protein sequence ID" value="KWX21061"/>
        <property type="gene ID" value="AFM11_27180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09944">
        <property type="protein sequence ID" value="ORX09944"/>
        <property type="gene ID" value="AWC31_07030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3311"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031409">
        <property type="entry name" value="Darcynin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17074">
        <property type="entry name" value="Darcynin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="108" mass="12958" checksum="B391538632AB6674" modified="2016-06-08" version="1">MFTVFMLVKTNPEWLGFPVAKRFDELTRHLQPILERHPEVKFRWYDTEFYTARVTDLLLWETTDPHEYELAVEELRETPFWDRYFTIVEILPGVANAYADNYGRSPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFH5</accession>
    <name>A0A132PFH5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-phosphate glycerol 3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_27385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855437.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_07320"/>
    <dbReference type="EnsemblBacteria" id="KWX21096">
        <property type="protein sequence ID" value="KWX21096"/>
        <property type="gene ID" value="AFM11_27385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3351"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="241" mass="26679" checksum="F5A08562105B599F" modified="2016-06-08" version="1">MWYWLFKFIFMGPLLSLLGRPKVTGLEHVPASGAVILASNHLAVADSFYLPLVVSRRITFLAKAEYFTGTGIKGWFTRWFYTVAGQVPIDRTDADSAQSALTTAERILSEGKLLGMYPEGTRSPDGRLYKGKTGLARLALQTGVPVIPVAMIGTDVVNPPGSKMWRFGRVEVRFGKPMDFSRFDGLAGNRFIERAVIDEVMYELMRLSEQEYVDLYAADVKENAENADAKPASRMPQTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFQ7</accession>
    <name>A0A132PFQ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_26340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854869.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_23250"/>
    <dbReference type="EnsemblBacteria" id="KWX21178">
        <property type="protein sequence ID" value="KWX21178"/>
        <property type="gene ID" value="AFM11_26340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3135"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="220"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="415" mass="45258" checksum="393A4DEA204A97E0" modified="2016-06-08" version="1">MRIALLSYRSKTHCGGQGVYVRHLSRGLAELGHDVEVFSGQPYPEGLDPRVTLTKVPSLDLYREPDPFRVPRPSEIRDRIDALELLTMWTAGFPEPRTFTMRVARILAERRDEFDVVHDNQSLGSDLLKIAGLGLPVVATVHHPITRDRVVDVAAAKWWRKPLVRRWYGFAEMQKKVARQIPELLTVSSSSAADIAEDFGVAPGQLHIVPLGVNTELFKPAEQRVSGRIIAIASADVPLKGISHLLHAVSRLRVERNLDVQLVSKLEPNGPTEKLIAELGISDIVHSSSGLTDEELAGLLASAEVACIPSLYEGFSLPAVEAMASGTPIVASRAGALPEVVGPDGECARLVRPADVDELTAVLGQLLDSPLERRRLGAAGRQRALDVFSWESVAAQTVSVYELARERMGKKVGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFT1</accession>
    <name>A0A132PFT1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_27055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000022">
        <property type="protein sequence ID" value="KWX21134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06900"/>
    <dbReference type="EnsemblBacteria" id="KWX21134">
        <property type="protein sequence ID" value="KWX21134"/>
        <property type="gene ID" value="AFM11_27055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3285"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="149" mass="16079" checksum="12D25D4AEE835525" modified="2016-06-08" version="1">MAEKMFAHQISERGLADAVRVTSAGTGSWHAGDGADARACLVLTEHGYPSGHRAAQVDDDHLSADLVVALGRNHARILADLGVQPERLRMLRSFDPRSGAHTPDVEDPYYGTRDDFEAVFTVIEAALPGLHDWVDAALAARDEPRGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PFV1</accession>
    <name>A0A132PFV1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_26185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854784.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21154">
        <property type="protein sequence ID" value="KWX21154"/>
        <property type="gene ID" value="AFM11_26185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3103"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="53"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="310" mass="33840" checksum="1E67A926DF90416D" modified="2016-06-08" version="1">MNTVRDFDAYARFLPPQYRAEPLIEPTSTWWPWRGRTVHIARAAVPDSDIRALVLHGAGGYSGALWPFAAFAAAEGADVLVPDLPLYGDTVVPRPASVRYDDWVELLCDLVRAECERDDRPLIVFGASMGGLLGYEVAARTRLVTHVVATCLLDPADPAARRAASRISRLGGVAPGLMRVAEPVMGGLRVPIRWLVKMTAMSGNRELSRLCATDPKGGGIRVPLGFLSSWLNFAHTAPETFDAAPVTLVHPGADRWTPPALSIRFLDRIAAPTQLVMLENCGHYPVEEPGLSQLVSALRRVREQALDQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PG38</accession>
    <name>A0A132PG38_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_26570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000021">
        <property type="protein sequence ID" value="KWX21273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067855146.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22765"/>
    <dbReference type="EnsemblBacteria" id="KWX21273">
        <property type="protein sequence ID" value="KWX21273"/>
        <property type="gene ID" value="AFM11_26570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3184"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453221" evidence="3">
        <location>
            <begin position="31"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="383" mass="38353" checksum="D580529C27AF32E8" modified="2016-06-08" version="1">MRSRLRVAASTCLVISGLFIAGLGGALAFADPDRGGGQRPSTGTDGGGPRGNGHDGDHDHTHGHGHDGEHGDDDDGNGPTRPSHGGTKPTKPTKPTKEPTKTDHPTKTDEPSGSPQPSGSGTVTNTNTATSQSHTPTEPTTEPSTEYPTTQTTSGTSVTSSATTTSRTTTTTDPTTTEPTTTDPTTTEPTTTDPSTTSRTTSATTTIVIGETGGGGGGGGAVPPEIRQPRPPAMQLPEVAAPLPAPAGPGLAAAAGAVPPPPIVMPVVVPPVVVPPILPPGNPDDNDSSSGPDRQPEVTATLKQQQPTSGGPLAVGYDAAVPPASFRVGYTDYLRTAGVFEIAAVAVPGVAGILGLTGLGGFVGYRQAKAALSARNGTNRFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGA8</accession>
    <name>A0A132PGA8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_25820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21343">
        <property type="protein sequence ID" value="KWX21343"/>
        <property type="gene ID" value="AFM11_25820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3028"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="71" mass="7852" checksum="9FC0B0A9F7EC7B2A" modified="2016-06-08" version="1">MRCRKRDAVTARRQIEGIDVPVVPAGSRGTVLTTTMLGRPKRVFFAVSDGWGLKRFQVTVRPGDVQVADQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGB8</accession>
    <name>A0A132PGB8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_25650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000020">
        <property type="protein sequence ID" value="KWX21314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854460.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_36245"/>
    <dbReference type="EnsemblBacteria" id="KWX21314">
        <property type="protein sequence ID" value="KWX21314"/>
        <property type="gene ID" value="AFM11_25650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2994"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="405" mass="42141" checksum="01A4CEEF60DA00CE" modified="2016-06-08" version="1">MVKPERRTRGDMVAAAAIVVVVAVAAGLIWWTSDARATISRPAASPVPYLTPADQVPAGLQQLWATPSPKTTAPVVAGGAVVTGDGRTVDGRDPVSGAVLWSYARDVELCGVTSVYQYAVAVYPDVRGCGQVSTIDGKTGRRGPARTGYSDPEVRLASDGVTVLSAGDSRLELWRSDMVRMLSYGALDARIKPDVPASPVCRKLSAAASSSAVSVLESCPKQKDVRLTLLRPADEEDTPEVRYVELPGVTDDSGAQVIAVSETTTAVYVPTPRPTVNIIDETGATVASTLLAKPAAPQSTTTKAGDLITWWTGDSVLVFSASGLRYKFTVTPSGPHVPVGPATLMAGRLLVPVDDGYDVFDPATGTGERHIAVAREPSVSPVVPAVAGSTVLEQRGTELVALGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGM5</accession>
    <name>A0A132PGM5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_24925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854077.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27180"/>
    <dbReference type="EnsemblBacteria" id="KWX21463">
        <property type="protein sequence ID" value="KWX21463"/>
        <property type="gene ID" value="AFM11_24925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2346"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="191" mass="20436" checksum="4DD4008D4DE7D034" modified="2016-06-08" version="1">MTDQFATLTRQCWLFVIGSSFFAVATAPGFPALAGAGATNVLCFIGSWFFTTAAWMQLALADRTRGTEWWSAQTQFVGTLMFNVSTGTSVWVHAVLAERRFVWAPDATGSSAFLVSGVLAIFAVGMWAPKSVDWQAAWINLAGCVAFGVSALAAFVRKTGVTVDERLANFGTFLGALCFLTAALLLRPRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGP3</accession>
    <name>A0A132PGP3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_24765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067853991.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27020"/>
    <dbReference type="EnsemblBacteria" id="KWX21434">
        <property type="protein sequence ID" value="KWX21434"/>
        <property type="gene ID" value="AFM11_24765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2314"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="257" mass="27080" checksum="45D9044C3BB4A44A" modified="2016-06-08" version="1">MDLRLADRAFLVTGGTRGIGLATTRLLLDEGASVMVAARTPASIAKASADLGEQTRLGFVQADLREANSGRVVVKAAVDRFGRLDGVVNNASAFSIDHGHPQRADWADLFELKLLGYETVLQAALDSFGDDGSVVNISGIASKRYWPESPHVSAVNSAVEALTRHYAAALAGRRIRVNTVVPGTTATDRYRGRVHRLQQRDGLDAAEAKRVVDASVPLGRPVEPEEIAAAVVFLLSEVSASTTGATLVVDGGAVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PGR1</accession>
    <name>A0A132PGR1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_24875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000019">
        <property type="protein sequence ID" value="KWX21454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067854052.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_27130"/>
    <dbReference type="EnsemblBacteria" id="KWX21454">
        <property type="protein sequence ID" value="KWX21454"/>
        <property type="gene ID" value="AFM11_24875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2336"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX21454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="235" mass="25370" checksum="D6153806B5C98022" modified="2016-06-08" version="1">MNIRHDVPAAFDAGAAAYDGLVDANPGYHDHLRLSARRMALPDGGRGMRLLDAGCGTGASTAALLAAAPHAEIVAVDGSAGMLAQARAKDWPKSVSFIQSYVEQLAANGVHGPFDGIFAAYLVRNLADPDTVLRTFRDLLRPGSTLAVHEYSVRDSRSARMMWNLVSTAIIIPMGRIRTGDAALYRYLRDSVNGFDGVSEFLNRLRQNGFVNTRSATVSGWQRGVVHTFLAESPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHA6</accession>
    <name>A0A132PHA6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_24320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000018">
        <property type="protein sequence ID" value="KWX21729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX21729">
        <property type="protein sequence ID" value="KWX21729"/>
        <property type="gene ID" value="AFM11_24320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2223"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX21729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="154" mass="16707" checksum="C7291A4868B17636" modified="2016-06-08" version="1">MPDIAAAAGVGRTTVHRYFPDREYLIYQATLDSIAMVNQLAVDVAADQGPAREAMHRVINAMVSIGDRVVFLFGDPAVMRNIAPDDHPDDAPLMDLIKRGQAEGVFSSELSATWIEHTLFALVLKGCQDAAAGELARHVVAPTIIRTFEHGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PHX7</accession>
    <name>A0A132PHX7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Dihydrodipicoline synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_22395</name>
        <name evidence="2" type="ORF">AWC31_08815</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX10248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852710.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08815"/>
    <dbReference type="EnsemblBacteria" id="KWX21921">
        <property type="protein sequence ID" value="KWX21921"/>
        <property type="gene ID" value="AFM11_22395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10248">
        <property type="protein sequence ID" value="ORX10248"/>
        <property type="gene ID" value="AWC31_08815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1829"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX21921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX10248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="297" mass="30678" checksum="2B61A8FAD361D09B" modified="2016-06-08" version="1">MNTVLAHGLWGVLATPFDEHLDIDLESLRNEVASFSGDGCDGLVALGVFGEAASLEPAEADAVAQTVATATDLPYVLGLSERDPDAVVAQAQRLLGAVSRPPAALMAQIGDANPAVAAESLRRLHDATGIGVLIQDYPVVSGVSVTDEQVVALVRACPFAVGVKSETPPTSAAIAHLAPRLDVPVFGGLGGVGLLDELAAGSAGAMTGFSHPAVLAAVLRAYRDGGFAAAREVFAPWLPLANFEGQLRVGLAIRKEVLRRRGVIAGSRVRRPAMPLPASLVGLLDQHLATLPHHASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI71</accession>
    <name>A0A132PI71_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4333 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_22870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852871.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08330"/>
    <dbReference type="EnsemblBacteria" id="KWX22003">
        <property type="protein sequence ID" value="KWX22003"/>
        <property type="gene ID" value="AFM11_22870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1927"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025637">
        <property type="entry name" value="DUF4333"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14230">
        <property type="entry name" value="DUF4333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4333" evidence="3">
        <location>
            <begin position="176"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX22003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="266" mass="28276" checksum="2FA1A4F042B21A7E" modified="2016-06-08" version="1">MSGPQGSDPSQPWPGQQPEPGRDQPSGGEAWQPPAGGSDDPTTHTPAWQPPAYTQQPQQQYPQYQQPSQPGYGQQPQQPQYPSTEQFGQQQGYPGQYGQPGQAGQPGQPGQYGQPGQYGQPGQYGQQPQYGQPGQFGQPGQFGQYTPPGAADGSKRSLGVIGGIVGGLVALVIIAVAVTAFWLPGWAVTTQLDINKAQSGVQQILTDETNGYGAKNVKDVKCNDGENPTVKKGDTFTCEVSIDGTKRQVTVTFQNDDGTYEVGRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PI75</accession>
    <name>A0A132PI75_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glutaminase</fullName>
            <ecNumber evidence="3 5">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glsA</name>
        <name evidence="6" type="ORF">AFM11_22575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3 5"/>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852959.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22046">
        <property type="protein sequence ID" value="KWX22046"/>
        <property type="gene ID" value="AFM11_22575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1865"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX22046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="297" mass="31266" checksum="75AE2CA674AAF660" modified="2016-06-08" version="1">MRDYLLAAQERGREAARTGHVSRQVPALADVAATRFAMAVATVDGAHAHIGDSDTGFSIQSVSKLFALCALLRHDPDAWTEVGWGPTDAGYGSVADLERNHWRPRNPFVNPGALVVTDRLLMHTGDAVNATIELIRCGHPGAPVYSDSLVAQSEMVADHRNSAIAHVLAEHGRLINDIDRILPQYFAQCAITASVQTIARAGLFLADRTGGHVVLDAATVRRVNAVLLTSGMYGAAGDIAYRIGLPAKSGIGGGVLAVMPGRGTVCVWSPPLDGDGNSAGGVTAIEEFARLAGWSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIC0</accession>
    <name>A0A132PIC0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX21937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08710"/>
    <dbReference type="EnsemblBacteria" id="KWX21937">
        <property type="protein sequence ID" value="KWX21937"/>
        <property type="gene ID" value="AFM11_22500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1850"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX21937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="108" mass="11723" checksum="5C72F5A5E4559329" modified="2016-06-08" version="1">MTEQPEQSAESDETVVEGEVVPPATGPIPTPTSHSPETGYTPAGVPTFESVREKIETRYGTSIGASELAADTPEGRAVEEQYDARQRAAAERLEQIRQSMRDDDSEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIG0</accession>
    <name>A0A132PIG0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08665"/>
    <dbReference type="EnsemblBacteria" id="KWX22044">
        <property type="protein sequence ID" value="KWX22044"/>
        <property type="gene ID" value="AFM11_22540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1858"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="261" mass="29454" checksum="0EC755D33A4DD9A4" modified="2016-06-08" version="1">MSAQPTAYPDVATRDDWLAARKKLLAREREVTHLRDAVNAERRRLPMVKVEKDYVFEGPDGEVRLLDMFEGRSQLYIHHFMWIDANDAGCPSCTAAADLTFTEKDRALLHAKDVTFACVSRAPYSSIARYRDQHGWTFPWYSSCDGDFTYDYHVTLDPARAPIEYNYKSLDDLHAAGFSDDDLHGDWPGASVFLRRGDEVFHTYSAYARGLDHSSVGYPFLDLTPYGRQEPWEDSPAGWPQGGIAAGMPVAGPADECNHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PII2</accession>
    <name>A0A132PII2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852401.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04495"/>
    <dbReference type="EnsemblBacteria" id="KWX22113">
        <property type="protein sequence ID" value="KWX22113"/>
        <property type="gene ID" value="AFM11_21690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1686"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="120"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="455" mass="50014" checksum="8DC816AB793EFE7F" modified="2016-06-08" version="1">MSPNPGMLAQADLEQMVAAGEIDTVIVAFCDMQGRLTGKRVSARLFVEEVAAHGAECCNYLLAVDVDMNTVDGYAVSSWETGYGDMVMTPDFATLRLIPWLPGTALVMADLSWLDGNPVTVAPRSILNRQIDRLAERGLVPFVGTELEFMVFDNTFREAWANGYRDLTPATDYNVDYAMLASTRMEPLLRDIRLGMEGAGMYCEGVKGECNRGQQEIAFRYDHARVTCDNHTIYRNGAKEIADQHGKSLTFMAKFDEREGNSCHIHISLRGEDGSAVFADESAPLGMSAMFRSFIAGQLATLRELTLFYAPNINSYKRFVDGSFAPTAVAWGMDNRTCAMRVVGHGHGMRVECRAPGGDVNQYLAVSALIAGGLYGIERELELPDALPGNAYTSGAQRLPTTLAEAAELFEKSEVARAAFGDDVVEHYLNNARVELTAFNAAVTDWERVRGFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIL0</accession>
    <name>A0A132PIL0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein lppK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_23020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852925.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08190"/>
    <dbReference type="EnsemblBacteria" id="KWX22027">
        <property type="protein sequence ID" value="KWX22027"/>
        <property type="gene ID" value="AFM11_23020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1955"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453379" evidence="2">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="179" mass="18589" checksum="0D920DE64949DC8F" modified="2016-06-08" version="1">MIRSRIAVLSAATVTVAALGLSGCGNDDRPAATPATSPTASELMPPPPPPADPLPAPDALTGVLYRLADVNVPGAEKVNLVEQSTPDDAAALDKFGRALVDNGFTPLSFEATDLAWSQTEPGNVVATINVSTAGDEPSRRFSFPMEFTQSGPDWQLTRHTADLLLEMGASAAPSPTPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIN4</accession>
    <name>A0A132PIN4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase</fullName>
            <shortName evidence="7">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pnp</name>
        <name evidence="10" type="ORF">AFM11_22150</name>
        <name evidence="11" type="ORF">AWC31_04910</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="7"/>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852560.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04910"/>
    <dbReference type="EnsemblBacteria" id="KWX22196">
        <property type="protein sequence ID" value="KWX22196"/>
        <property type="gene ID" value="AFM11_22150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10628">
        <property type="protein sequence ID" value="ORX10628"/>
        <property type="gene ID" value="AWC31_04910"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1779"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014069">
        <property type="entry name" value="GPSI/PNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02696">
        <property type="entry name" value="pppGpp_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="660"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KWX22196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX10628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="757" mass="80780" checksum="744FC28D8A7DE1D8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIR6</accession>
    <name>A0A132PIR6_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Alanine dehydrogenase</fullName>
            <ecNumber evidence="3 6">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFM11_22175</name>
        <name evidence="13" type="ORF">AWC31_04935</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reductive amination of pyruvate to L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000032">
        <property type="protein sequence ID" value="ORX10633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852570.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04935"/>
    <dbReference type="EnsemblBacteria" id="KWX22201">
        <property type="protein sequence ID" value="KWX22201"/>
        <property type="gene ID" value="AFM11_22175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX10633">
        <property type="protein sequence ID" value="ORX10633"/>
        <property type="gene ID" value="AWC31_04935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1784"/>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="10">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX22201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX10633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="371" mass="38756" checksum="F35D42360AFA6795" modified="2016-06-08" version="1">MLVGIPTEIKNNEYRVAITPAGVAELTRRGHDVIIQAGAGEGSAIADNDFKAAGAEIVTSADQVWADAELLLKVKEPIEAEYSRMRKGQTLFTYLHLAASKPCTDALLASGTTSIAYETVQTADGALPLLAPMSEVAGRLSAQVGSYHLMRTQGGRGVLMGGVPGVAPAEVVVIGGGVAGYNAARIAKGMGAHVTVFDLNINTLRKIDNENSGSIETRYSSSLELEEAVKKADLVIGAVLIPGAKAPKLVTNSTVAHMKSGAVLVDIAIDQGGCFEDSRPTTHDDPTFKVHDTVFYCVANMPGAVPRTSTFALTNATMPYVLKLADKGWQAACAADPALAKGLSTHEGGLLSEQVAKDLDLPFTDPAPFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIU5</accession>
    <name>A0A132PIU5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose 5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_21720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000015">
        <property type="protein sequence ID" value="KWX22223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852617.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_04525"/>
    <dbReference type="EnsemblBacteria" id="KWX22223">
        <property type="protein sequence ID" value="KWX22223"/>
        <property type="gene ID" value="AFM11_21720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1692"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="157" mass="16982" checksum="6A9DCD14742EF02E" modified="2016-06-08" version="1">MRIAIAADHNAVAMKSRLTTWLTERGHHVDDRGVHDAAETADYPPLCADIGAVVVDGSHDFGVVLGGSGCGEQIAANKIRGVRAVLCHCVFTAEIARAHNNANVLVMGAKVVAPDLAERILDVWLTTRFKGGRHQLRLDQISALETRELQQVRTSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PIV7</accession>
    <name>A0A132PIV7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20550</name>
        <name evidence="3" type="ORF">AWC31_05965</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851991.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05965"/>
    <dbReference type="EnsemblBacteria" id="KWX22233">
        <property type="protein sequence ID" value="KWX22233"/>
        <property type="gene ID" value="AFM11_20550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09765">
        <property type="protein sequence ID" value="ORX09765"/>
        <property type="gene ID" value="AWC31_05965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1447"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="74" mass="7813" checksum="7CCCE1A3708B5B2D" modified="2016-06-08" version="1">MGAILSWWDGVELWLTGLPFVVQTAVVMPVVLALAYGAAVVLDGALGQGTAGIRRLRRAGADESDELAEAMRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ19</accession>
    <name>A0A132PJ19_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_22915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000016">
        <property type="protein sequence ID" value="KWX22012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852889.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_08285"/>
    <dbReference type="EnsemblBacteria" id="KWX22012">
        <property type="protein sequence ID" value="KWX22012"/>
        <property type="gene ID" value="AFM11_22915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1936"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="292" mass="32036" checksum="A9DEB69FC235ED65" modified="2016-06-08" version="1">MSSRSSRSAPVDGFRLAFDRHGISGGPAVILLHGWPGNRRDHRHVVPLLTDIADVVVPDLRGFGGSDKHAVSVQHFYSASAQAASVVGLINELGLDDVVLAGYDVGSRVAQSVARMHPHLVKALVLSPPLPGAGDRVLSPHAMHEFWYQAFHQLPIADRMIDGNPDAVREYLRHFWDHWSGPSFQVSEDDLDRLVADYALPGAFTASLGWYRAGAGTVAQSLTELPPGRAVKIHASTDVLWPQHDPLFPPEWADRLEHYFVDVRLHKVNGAGHFTPVECPEEFAALIRRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ28</accession>
    <name>A0A132PJ28_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852265.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06475"/>
    <dbReference type="EnsemblBacteria" id="KWX22368">
        <property type="protein sequence ID" value="KWX22368"/>
        <property type="gene ID" value="AFM11_21110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1569"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="170" mass="18013" checksum="A0A80F31015EA27D" modified="2016-06-08" version="1">MLIRRATPDDRSALRDVHNAAFASDAATQSVEATLVDQLGAAGDSIPALSLVAEIDGAVVGHVLGSRAQLDGRPSLALGPLGVLPTHQRHGVGSALMHAVLAAADALGFPEAVLLGDPAYYCRFGFRPAPPLGVRPPVKEWAEHFQIRTLTSWTPDRQGTFRYAPAFDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ38</accession>
    <name>A0A132PJ38_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_21270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852278.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06635"/>
    <dbReference type="EnsemblBacteria" id="KWX22378">
        <property type="protein sequence ID" value="KWX22378"/>
        <property type="gene ID" value="AFM11_21270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1600"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4185" evidence="1">
        <location>
            <begin position="16"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="350" mass="38816" checksum="0F966BEE7DB3C474" modified="2016-06-08" version="1">MPLRNGKVCDLTGPGLTDRFGVTCTDLGASVLAPNGKLVSVFGDTFSGRRVGEGDWRSPVVLIGTGDANHEIVYERAGGPDPLYARQLWHYVHNASGWRRNAISTVIPSDLLRVGDSLYLHAIVNRGFGNVIWTEIWRSDDCGVSWERFGSKFPAGLHGSHAQCWSWDHDPDDGWVYVASTGFQRDKGIILMRVRPGRIGDPESYWSWGHTDAGWEWGRRATPITPAAERWGELSFRRVAPGKWVLGGFFASKYALGYRVIDSPLANLHTTPVQTPIAGSTWENEDHAQNRVAQLYGGYVLPGSRFDIDGGVGLVVSQWHTNSGWPYRAMQFKARLKDTSEPQPVDPVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJ47</accession>
    <name>A0A132PJ47_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_21130</name>
        <name evidence="2" type="ORF">AWC31_06495</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000014">
        <property type="protein sequence ID" value="KWX22331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067852200.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_06495"/>
    <dbReference type="EnsemblBacteria" id="KWX22331">
        <property type="protein sequence ID" value="KWX22331"/>
        <property type="gene ID" value="AFM11_21130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09856">
        <property type="protein sequence ID" value="ORX09856"/>
        <property type="gene ID" value="AWC31_06495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1573"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX22331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX09856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="213" mass="23029" checksum="426FC134CD6BA7CC" modified="2016-06-08" version="1">MTLPATRWYQWHAQYDDLHSPDTDRLEVVQELIIAALDRAPAGPLTAVSACAGQARDLLPVLIHHPRGRDVRARMVELDPLNASFLTAALGSTDLVGVEVVIADAGTTDAYIGAVPADLVLLCGVFANIELDDAQRTVDAATALCRPGGIVVWSSYGAQLAHADEVVALFEDRAFERMALRRSAEREFVVASHRYVGPQRSLPAHARFFGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJD7</accession>
    <name>A0A132PJD7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851887.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28485"/>
    <dbReference type="EnsemblBacteria" id="KWX22445">
        <property type="protein sequence ID" value="KWX22445"/>
        <property type="gene ID" value="AFM11_20030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1342"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="299" mass="30770" checksum="428D7675EE7F9C3C" modified="2016-06-08" version="1">MSLLGGYESGAGLNHHEADAPKRIPVPSLLRSLLSDHLDPGYAAAAAERESTGRARPRVWEWGWQILAALAIATVFAVAAAQAQTAAPAAREAQHALAGRVRAAEAGADKASAERGALVDQVDAERRARLGMDEDGQQLLSSLDTANIAAAAVPMIGPGLTVTVTDPGVSKDLSDVSKQRVAGSQQVILDRDLQLVVNSLWASGAEAISVGGVRVGAGVTIRQAGGGILVDNQPITSPYVIVAIGPPNGMSDAFDRSPGLQRLRLLETSYGVGVNVSAGDGLDVPAVGVRDVNFAKQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJN4</accession>
    <name>A0A132PJN4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_20190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851917.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_11525"/>
    <dbReference type="EnsemblBacteria" id="KWX22474">
        <property type="protein sequence ID" value="KWX22474"/>
        <property type="gene ID" value="AFM11_20190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1373"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="9"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="256" mass="27727" checksum="D312208F6F938EAA" modified="2016-06-08" version="1">MRSFTRYVALGDSQTEGLWDGDDTVGLMGFADRLALELDGHYPGLGYANLAVRGHRISDVLSDQLPQALSMRPDLVTICIGMNDVTRPGRSFNRALDDLDRIYAALSASGATVVTTTFPDITQILPVGRLLGKRVLHINAAITAAADRYGFRLVDLYSAASMREAETWSPDRVHGSAKGHMLFAAAAAEALGLPGSSHDWAHAGGAAEPQSFRSRAYSQALWTQNMLMPWIWRHLRGRSAGAGRAPRRPVLLSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJP9</accession>
    <name>A0A132PJP9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_20125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000013">
        <property type="protein sequence ID" value="KWX22533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851979.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_29985"/>
    <dbReference type="EnsemblBacteria" id="KWX22533">
        <property type="protein sequence ID" value="KWX22533"/>
        <property type="gene ID" value="AFM11_20125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1360"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX22533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="412" mass="41867" checksum="D41E141D96897CB3" modified="2016-06-08" version="1">MPPRPALGQRESVDLRRARIAVAALFLTNGAIFANLLPRYPEIKTDLGLSNAVYGAAVSAFSGGALVAGLTAGVLIRRFRSSRVAVIGTIALGTFVVTAGLAASPVMFAAALFIAGACDAVVDVAQNAHGLRLQRDYGRSIINSLHAVWAVGAIVGGLTGAATIALGVPRGIHLAAIAVVFSVVVLVAYRYLLPGPDHDDHPAALAPAGTKAGPRVYLTLLALVVIAIAGATVEDAGSSWATLYLRDTLHAPPAVAVFGYIALVGFMFVGRLVGDRMVDRFGEATVVRVGGLITAAGMGAALAFPSIAGSIAGFAAAGLGVATLIPAAMHAADQLPGLRPGTGLTAVTWLMRIGFFGAPLLVGMIADAAGLRVGLVVVPIVGVLVMLLAGVLRRAPSVGGAGDLDREHTRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJW1</accession>
    <name>A0A132PJW1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_18975</name>
        <name evidence="3" type="ORF">AWC31_15065</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000006">
        <property type="protein sequence ID" value="ORX17756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851581.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22593">
        <property type="protein sequence ID" value="KWX22593"/>
        <property type="gene ID" value="AFM11_18975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17756">
        <property type="protein sequence ID" value="ORX17756"/>
        <property type="gene ID" value="AWC31_15065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1129"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453333" evidence="1">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX22593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX17756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="78" mass="7951" checksum="A52FC3B24BA4D948" modified="2016-06-08" version="1">MKMPLKFIAPWLAAAAIGGAVAFAPVASAADTNTHSQVSGTDPLVPVGTDPVIPYRLGYVDSNHDEANTTGGGVDLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PJW6</accession>
    <name>A0A132PJW6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851675.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22640">
        <property type="protein sequence ID" value="KWX22640"/>
        <property type="gene ID" value="AFM11_19265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1187"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="272" mass="29492" checksum="B48885777CAD2BC5" modified="2016-06-08" version="1">MGRTVAVIWHASFSIVAAGLYFFFVIPRWPELMGQTSPTVGLVLRIVTGVLIGLAALPVVFTLQRTQRPEFGTPQLALRLRSWSIVLHVLAGLLIVGTAISEIWLSLDTAGQWLFGIYGAAAAMALLGVFGFYLAFVAELPPPPPKPLKVREAGERRGRGKTDEKTEADDEPADEADKDEAEKPEADETEDTVDADETEEKPAEVTAEEADDPAEKTAETADDTAEDDGTDESSASDEDKNSNGKLRNRRPSNKGGNSRLRWRSRGGVAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PK39</accession>
    <name>A0A132PK39_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_19660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000012">
        <property type="protein sequence ID" value="KWX22706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067851789.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15725"/>
    <dbReference type="EnsemblBacteria" id="KWX22706">
        <property type="protein sequence ID" value="KWX22706"/>
        <property type="gene ID" value="AFM11_19660"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1266"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="47"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="225" mass="24177" checksum="7E618C263AD0CD87" modified="2016-06-08" version="1">MTSQDVLDWDGAYRGESGFEGPPPWNIGEPQPELAALHQAGKFRSDVLDAGCGHAELSLALAADGYTVVGMDLSPTAIAAANRAAQERNLSTASFVQGDITSFTGYDGRFNTVIDSTLFHSLPIEGREGYLSSIHRASAPGASYFVLVFAKGAFPSEMEVKPNEVTEEELRAAVSKHWEIDDIRPAFIHANAIAIPDAPFDPPPHGVDEKGRIKFPAFLLTAHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PKR4</accession>
    <name>A0A132PKR4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_18490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000011">
        <property type="protein sequence ID" value="KWX22940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_12490"/>
    <dbReference type="EnsemblBacteria" id="KWX22940">
        <property type="protein sequence ID" value="KWX22940"/>
        <property type="gene ID" value="AFM11_18490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.1032"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX22940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="265" mass="29205" checksum="E8887912E09B265F" modified="2016-06-08" version="1">MVAHQVRKTFPPRKTGRVRSDELTVLTDFELAIPDGEFLALLGPSGCGKSTFLNILAGLETLSGGEVLVSGEPLAGVNRDIGVVFQGYALYPWRSVLANVEAGLEIRGVPKAERRRTATQLLDKVGLGEFLHSYPHQLSGGMRQRVAIVRALAYDPSVLVMDEPFAALDANTRELLQLELLRIWGLSQADGAKRKTVLFVTHSVDEAIFLADRVAIMTARPGRVKATIDIDLPRPRTEEIRNSPEFVEIRRTVSEILREEVRGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLF6</accession>
    <name>A0A132PLF6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_15210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850147.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_15830"/>
    <dbReference type="EnsemblBacteria" id="KWX23176">
        <property type="protein sequence ID" value="KWX23176"/>
        <property type="gene ID" value="AFM11_15210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7154"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025646">
        <property type="entry name" value="DUF4350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14258">
        <property type="entry name" value="DUF4350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453396" evidence="1">
        <location>
            <begin position="23"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4350" evidence="2">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="370" mass="39151" checksum="EBB4145D0107F68B" modified="2016-06-08" version="1">MRQRMRTARWVILGLVAIVVVAAVGTYLTAPRPGGRMDAESTSPDGARALVTLLRDHDVEVITAATAEDAHRAAQPGSLVVAAQTLFLSSDEQLAQLADAPGDLLLIEPVTKTREALAPHLKAGEASAFGGGEPDCELAEANRAGEAQFGLTDTFEAAGDVPVTRCYGGAVARYHDEGRTVTVVGTAEFMSNSGLLKQGNAALAMNLAGTAPRVIWYAPQRFEGETSASATLSDLMPDQVRWIVYQLVLVVALLAVWQVRRIGPLVAESLPVVVRASETVEGRGRLYRSHRARDRAADALRTATLQRLLPRLGLTAAAEPPAVVAAVAARCGGDNGSLGHLLFGPPPTTDSELVHLAHQLDDIERQVAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLV0</accession>
    <name>A0A132PLV0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_16595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX22992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850681.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX22992">
        <property type="protein sequence ID" value="KWX22992"/>
        <property type="gene ID" value="AFM11_16595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.668"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="322"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX22992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="403" mass="42957" checksum="6379AD0D580C9532" modified="2016-06-08" version="1">MTDVGRIALIGGGIAAASAAQELRRQGFDGAITLLTRELDAPYHRPPITKALLSDPAHDVQFASLDWWSDHDIEVRTRSAVSALDVGAHVVTLTNKQTLDYDKALIATGAMVRRLAIEGSALPGIHYLRTPANAHKLREEAAVAERIVLVGGSFIAVEVAASMTAQGRQCTLVMQENLCLERTFGPTVGTFVDELLRRRGVEIIGRSDVAAFMGTDVLSGVRTAGGAEIPCDLAVVGVGAVPDAKLATKAGLQIGESGGVRCDSQLRTSHPDVYAAGDVCEYYSVAHGRQLRVEHERHAAAQGVTAALNMIGAGRDHAEVPYFWTDIADWARLEYVGAARHWDEEVVTGSPEDGVFTVWYLDGGRLVAALTNGRSDDLDLARSILTAGPDDKVCARTLIGQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PLZ5</accession>
    <name>A0A132PLZ5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_16245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000009">
        <property type="protein sequence ID" value="KWX23356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850521.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_16850"/>
    <dbReference type="EnsemblBacteria" id="KWX23356">
        <property type="protein sequence ID" value="KWX23356"/>
        <property type="gene ID" value="AFM11_16245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7374"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="427" mass="47552" checksum="DAD7B1EDF142A163" modified="2016-06-08" version="1">MTDLASVDYFSDPAITQDPYEYFDYLRSQGPVFAEPHHGVVAVTGYQEVMAAFKDTDSFSAVNAIGGPFPPLPFEPEGDDISAQIEAHRHEFPIFEHMVVMDPPEHERARSLLSRLLTPRRLKENEDYMWQLADRQLDEFIANGRCEFLSEYAKPFATLAITDLLGVPEEDRAEFRLALGAGKQPGSRVGALDGEPVGLNPLQYLDDKFSAYIAERRREPRADVLGGMASATYPDGSTPELLEVVRPATFLFAAGQETVTKLLSAAVQTLGERPEYQQLLRDKPELIPAFIEEALRTQSPTKVDFRLARKTTTLGGVHIKAGTVLMLCLGAANRDPRKFPQPNEFDIERPNVREHIAFGRGIHTCAGAPLARVEGVITVHRLLDRMRDITISEDAHGPAGKRHYAYEPTFLLRGLTELHIEFTPVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PM61</accession>
    <name>A0A132PM61_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_17290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000010">
        <property type="protein sequence ID" value="KWX23112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850935.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_01855"/>
    <dbReference type="EnsemblBacteria" id="KWX23112">
        <property type="protein sequence ID" value="KWX23112"/>
        <property type="gene ID" value="AFM11_17290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.811"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="155" mass="16660" checksum="BEDFFF7A6300862C" modified="2016-06-08" version="1">MSVKPIPEGYTSLTPFICVDGAAAAIEFYERVFGAKVVERMDGPDGTVAHAELDFGAGRLQLGDPQEAFQIAAPTPGAAATHSIGLYCPDVDDVVTRAEQAGATIREPAQTFVTGDRFASILDPFGQRWTVMTRVEDLSAEERERRVAEWAASNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMA1</accession>
    <name>A0A132PMA1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_13945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849657.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX23394">
        <property type="protein sequence ID" value="KWX23394"/>
        <property type="gene ID" value="AFM11_13945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6892"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="437"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX23394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="547" mass="58648" checksum="B5E21A702604E879" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMT2</accession>
    <name>A0A132PMT2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase AAA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Type VII secretion AAA-ATPase EccA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_14650</name>
        <name evidence="6" type="ORF">AWC31_18250</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000008">
        <property type="protein sequence ID" value="ORX17257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849893.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18250"/>
    <dbReference type="EnsemblBacteria" id="KWX23507">
        <property type="protein sequence ID" value="KWX23507"/>
        <property type="gene ID" value="AFM11_14650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX17257">
        <property type="protein sequence ID" value="ORX17257"/>
        <property type="gene ID" value="AWC31_18250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7039"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023835">
        <property type="entry name" value="T7SS_EccA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03922">
        <property type="entry name" value="T7SS_EccA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="353"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX23507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX17257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="611" mass="67908" checksum="E6D4F5ABEF6FDD3F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PMT4</accession>
    <name>A0A132PMT4_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_15065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067850114.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17775"/>
    <dbReference type="EnsemblBacteria" id="KWX23574">
        <property type="protein sequence ID" value="KWX23574"/>
        <property type="gene ID" value="AFM11_15065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.7124"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX23574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="186" mass="20050" checksum="313B715C19719AD1" modified="2016-06-08" version="1">MTQSIPTATNVDHVSWSVQDLDAAVSFCVEVLGGQEILRAGPFSDPSGDWMSTHFDVDARASASLAYVRLGATQVVEFIQWTATNRKEEWPLNSDVGASHLAIHVGDIDQAMRYLKEHGCSACGGPVLLEGVPHAGVTILYVRTPIGLLLELVSRPAHDLPYESATEARLLAPTQEWSNGQSAPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN25</accession>
    <name>A0A132PN25_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_14405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000008">
        <property type="protein sequence ID" value="KWX23597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18415"/>
    <dbReference type="EnsemblBacteria" id="KWX23597">
        <property type="protein sequence ID" value="KWX23597"/>
        <property type="gene ID" value="AFM11_14405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6989"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012042">
        <property type="entry name" value="NeuTTM/CthTTM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40114">
        <property type="entry name" value="PTHR40114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016487">
        <property type="entry name" value="CYTH_UCP016487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="132" mass="14441" checksum="29339E39D13CE76E" modified="2016-06-08" version="1">MVLKQGYLAVAADGSETRVRSTDDASFELTVKSAGDLVRGESTIPITREMFEALWPKSEGARIEKTRLRIPHGPHTIELDVYAGTLDGLVVAEVEFTDEADAATFAVPEWFALDVTSDKAYKNKNLATKGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PN48</accession>
    <name>A0A132PN48_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_12950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000007">
        <property type="protein sequence ID" value="KWX23694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067849153.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_03235"/>
    <dbReference type="EnsemblBacteria" id="KWX23694">
        <property type="protein sequence ID" value="KWX23694"/>
        <property type="gene ID" value="AFM11_12950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6682"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX23694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="147" mass="15864" checksum="54CB2053310C96F4" modified="2016-06-08" version="1">MTEPVTEQRREPGERPGPRPEDVDTGFWLWAVALPLLVIGYLLDVVTGARGDQRLLLIVFSVMFMVVLASIVGAFLVLLRQGYRWARTLLTSGGAVSVVHAVSSLLSGDRPAAVAVAYAVTAIVGSVLIVGGIYLLHRKDANGYFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNW9</accession>
    <name>A0A132PNW9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30360"/>
    <dbReference type="EnsemblBacteria" id="KWX24015">
        <property type="protein sequence ID" value="KWX24015"/>
        <property type="gene ID" value="AFM11_11665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6410"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="324" mass="34700" checksum="0FEF8DBF082D98BA" modified="2016-06-08" version="1">MSLLAGCGSSAGKTTTSSGGDTAGYPVAVENCGRTVTVKAPPQRAVSINQPATELLLTLGLADRMVGSASWSDEVRPELAAENAKVPVLSRDFPSFERVLKEKPDFVYATFDWSFTDEGVAPRDRFESLGVPTYQSSSECGGQDAAQQRPLTLDDMYAEIADVAKIFGVQDRADQLISSLRARKATAADGLKADGVTVMWWYAGTKTPYIAGCCGAPGIITTELGARNAFADNRQLWPEISWEAILERDPDVLILADLTRGDDGDSAAAKIRFLETDPAAKRLTAVRERRWIVLPGTAMDPSLRNVDAIETVAAGLRTLGVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PNY5</accession>
    <name>A0A132PNY5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_11830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848448.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30215"/>
    <dbReference type="EnsemblBacteria" id="KWX24046">
        <property type="protein sequence ID" value="KWX24046"/>
        <property type="gene ID" value="AFM11_11830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6445"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="50"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="453"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX24046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="538" mass="58260" checksum="68D11F604302EDBE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPA5</accession>
    <name>A0A132PPA5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_11800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848863.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_30245"/>
    <dbReference type="EnsemblBacteria" id="KWX24176">
        <property type="protein sequence ID" value="KWX24176"/>
        <property type="gene ID" value="AFM11_11800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6439"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="68"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="174" mass="19000" checksum="C214BE697693B844" modified="2016-06-08" version="1">MSKTVYYTASSLDGYIVDDNDSLDWLLTRNIDQGGPFGYDDFIKTIGALAMGSATYEWIVKNDPDGWTYDQPTWVLTHRPQIIVEGHPVQVFEGDITELHPKLVSAAAGKDVWVVGGGEIAAQFVAAGLIDEMIVSYTPCSLGAGSRVLPIRSEWVLAESAVNGDFVCARWTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPB8</accession>
    <name>A0A132PPB8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_12270</name>
        <name evidence="3" type="ORF">AWC31_09710</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000034">
        <property type="protein sequence ID" value="ORX09211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848681.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_09710"/>
    <dbReference type="EnsemblBacteria" id="KWX24124">
        <property type="protein sequence ID" value="KWX24124"/>
        <property type="gene ID" value="AFM11_12270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09211">
        <property type="protein sequence ID" value="ORX09211"/>
        <property type="gene ID" value="AWC31_09710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6533"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453175" evidence="1">
        <location>
            <begin position="22"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="325" mass="34050" checksum="47866F99C020C2E6" modified="2016-06-08" version="1">MKKIAVALFSVLVLAACGSQEAEKPAGWSDNDVSFDADGLTIHGTYRHEGKQGPAALLISESGPTDRNGDNKVVGPIGNMRQLAETLSDKGVASLRYDKVGTGKTGLGPYEQKPTDVTSAVYTTGAAAALRYLADQPDTDDGRLSVYAVGEGAIHAMTLAGAGDPKVHSLGLFQPLPGRYLDIITNRVRTDGNPEALTTWLAAVEQIRTKGTLPPNLPQGLSAIVNPGNLSAVVEADKIDPLELAAKLPDGMPVLLTCSDVDKQATCEAERPLIDALGHTALTVVELKGVNHILRDDPTDSIANYSKPAPLSPQVVDALAGFVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPI9</accession>
    <name>A0A132PPI9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09450</name>
        <name evidence="3" type="ORF">AWC31_05775</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000033">
        <property type="protein sequence ID" value="ORX09735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847114.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05775"/>
    <dbReference type="EnsemblBacteria" id="KWX24213">
        <property type="protein sequence ID" value="KWX24213"/>
        <property type="gene ID" value="AFM11_09450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09735">
        <property type="protein sequence ID" value="ORX09735"/>
        <property type="gene ID" value="AWC31_05775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5927"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX09735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="106" mass="11513" checksum="B4C41B154766DD7C" modified="2016-06-08" version="1">MSASASAVLDALGDKTRRSILEKLADGPVAVGVLADQLPISRPAVSQHLRVLKDADLVVESIAGTRRLYRVNEAGLVALRDYLDRFWVQALAGFKEVVERQEGDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPS5</accession>
    <name>A0A132PPS5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Myo-inositol 2-dehydrogenase</fullName>
            <shortName evidence="1">MI 2-dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iolG</name>
        <name evidence="4" type="ORF">AFM11_09785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose</text>
            <dbReference type="Rhea" id="RHEA:16949"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17811"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.18" evidence="1"/>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847291.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05440"/>
    <dbReference type="EnsemblBacteria" id="KWX24274">
        <property type="protein sequence ID" value="KWX24274"/>
        <property type="gene ID" value="AFM11_09785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5995"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01671">
        <property type="entry name" value="IolG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023794">
        <property type="entry name" value="MI/DCI_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="137"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX24274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="343" mass="36644" checksum="BE5D6B685ED0EAC7" modified="2016-06-08" version="1">MSDLRVAVLGVGIMGADHVSRLTSRISGATVTVVNDFITEKAEQIAAGIPGCRVIGDPLDAIADADVDAVVLATPGPTHDKQLLACLEHRKPVLCEKPLTTDVESSLEVVRREAELGTRLIQVGFMRRFDPEYMQLKSLLDAEEFGTPLVLHCVHRNPAVPPSFDSSMIVKDSLVHEVDVTRFLFDEEITSIQILRPAPNPGAPVGIQDPQIAIMRTASGKHVDVELFVTTGVGYEVRTELVGENGSAFIGLDVGLIRKGAPGTWGGQITPGFRERFGLAYDIEFQRWVDAVRAGAATGDYTDGPTAWDGYAAAAVCAAGVESLNSGDRVEVSMVDRAAIPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPT3</accession>
    <name>A0A132PPT3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847553.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX24356">
        <property type="protein sequence ID" value="KWX24356"/>
        <property type="gene ID" value="AFM11_10300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6097"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="91" mass="9489" checksum="C24FAD0E2C7194B9" modified="2016-06-08" version="1">MANELEVNVDGLRIAAAASEIDAATIAPATTYRNTSVRPSSVGISAIEAAVASVRRRQIRRISGQAIDLREGADSYDSADEVGADAITKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPU2</accession>
    <name>A0A132PPU2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847145.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_05705"/>
    <dbReference type="EnsemblBacteria" id="KWX24227">
        <property type="protein sequence ID" value="KWX24227"/>
        <property type="gene ID" value="AFM11_09520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5941"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="179" mass="19618" checksum="410C24042EE74752" modified="2016-06-08" version="1">MSDTAVVVVDMLNSYQHEDAELLAPNVARIIDPLVNLIKAARERDDVDLIYVNDNYGDFTAQFSDIVESALDGERPDLVRPILPEDGCLLLTKVRHSVFYATALDYLLGRLGTERVILAGQVTEQCILYSALDAYVRHFDVVVPADAVAHIDAGLGEAALEMMRRNMSADVVPAAECLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPV2</accession>
    <name>A0A132PPV2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_11970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000006">
        <property type="protein sequence ID" value="KWX24072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067848529.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10005"/>
    <dbReference type="EnsemblBacteria" id="KWX24072">
        <property type="protein sequence ID" value="KWX24072"/>
        <property type="gene ID" value="AFM11_11970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6473"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="511" mass="54521" checksum="FFDCC48E8E468CBB" modified="2016-06-08" version="1">MTDQAVAGSENAAHDVQRLKRNAVGTVGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAGYIVATIVLGLFAIGYATMAKHITATGAFYGFISHGLGRIVGMASGALITMAYVVFEASLIGIFAFFFQNLFLSQLGIHIHWIVPALLMLAANAILTYFDVNLTAKVLGVFLVTEIVMLALGALAVLFKGGGPDGFAVAETLNPIGAFTPAAGIAGASAGLGLFFAFWSWVGFESTAMYGEESRDPKRIIPRATMLSVLGVGLFYVFVSWMAIAGTGPRQSVELAQDAATSSEIFFGPVRGTYGEWAITVFNILLVTGSFACGMAFHNCASRYLYALGREGLSVGLQKTIGATHPKHGSPYIASFVQSGITLVIVLAFLFAGMDPYVHMYTLLAILGTMAILIVQSLCAFSVISYFHIRKNHPVSKHWFKTLVAPGLGGIGMLYVVYLLWQHRDTAAGTASGTLLFQLTPWIVVGLFIFGAAMATYFKLRDPRRYELIGRIVYEDAEIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PPW8</accession>
    <name>A0A132PPW8_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoisovalerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_10215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067847518.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18660"/>
    <dbReference type="EnsemblBacteria" id="KWX24345">
        <property type="protein sequence ID" value="KWX24345"/>
        <property type="gene ID" value="AFM11_10215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6081"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="31"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="352" mass="38472" checksum="FF2A9620072F4713" modified="2016-06-08" version="1">MTQIIDRPAAQGDSPEPWGPILTQVPVARELTMVQAINQALHDAMAADDRVLVFGEDVATLGGVFRVTDGVTETFGTERCFDTPLAESAIIGIAVGFAIRGFVPVPEIQFDGFSYPAFDQIASHLAKYRMRTHGDVDMPVTVRIPSFGGIGAVEHHSESTESYWLHTAGLKVVVPSTPSDAYWLLRQSITSPDPVMFLEPKRRYWAKEPVDTDTPGLPIGRAAVRRTGTDVTVLTYGGLVATALNAAELAAERGWRMEVVDLRSLNPLDFDTVADSIRRTGRAVVMHEGPRTLGFGAELAARISEELFYDLEAPVLRATGFDTPYPPARLEKVWLPGVDRLLDCVERAMGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQB1</accession>
    <name>A0A132PQB1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_10075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000005">
        <property type="protein sequence ID" value="KWX24485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_18560"/>
    <dbReference type="EnsemblBacteria" id="KWX24485">
        <property type="protein sequence ID" value="KWX24485"/>
        <property type="gene ID" value="AFM11_10075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.6051"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="120" mass="13735" checksum="54B1AE0FE78570EE" modified="2016-06-08" version="1">MYQHINHATMVTILEEARIPFLREPFGEEITTIGLLIAEVNIVYKGQLRLVDSPLQVTMWSKRVRAVDFTIGYEVRSVSAAPDSKPSVIAETQLAAVHIEEQRLQRLSPTQRAYLEHHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQF5</accession>
    <name>A0A132PQF5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_07560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846006.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_22060"/>
    <dbReference type="EnsemblBacteria" id="KWX24535">
        <property type="protein sequence ID" value="KWX24535"/>
        <property type="gene ID" value="AFM11_07560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5360"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX24535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="281" mass="28919" checksum="47F6CFF1B3CD701B" modified="2016-06-08" version="1">MDNPLNLDGRIVVVSGAGGGGIGTTVTRMAAEAGATVVAVSRSQDNLDTHVGPLADKGLAVISVAADASTDEGIATVLDVVRRTDGNLYGLVNVAGGAAPSTWMPSTRVSRADWRDLFTANLETMFFMSQAVAAEIRAGGNPGSIVSVSSISGMNTAPFHVAYGTAKAAIVAATRTMAAELAAAGIRVNAVAPGVTETAASATYVDADPERDRRAIAMGRRGTPEEQAGAILFLLSDLSSYITGQTLLVDGGLNLRWTHLGGDNTSLFLKDENFRAAITRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PQQ3</accession>
    <name>A0A132PQQ3_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol maleylpyruvate isomerase N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846200.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24545"/>
    <dbReference type="EnsemblBacteria" id="KWX24604">
        <property type="protein sequence ID" value="KWX24604"/>
        <property type="gene ID" value="AFM11_07945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5439"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="202" mass="20833" checksum="C36B1DFF8E4682A6" modified="2016-06-08" version="1">MTADVFASAAHAFARLVRALPADLFDGPGLGEWDLRALVGHTSRSLVTVSTYLHSPAAEATLAGPVEYYVAIRDFMSEAGAEAIVERGRQAGRDLGDDPVAAVEQLVEQALSDIDGVGDPPITVIGGYGIRLSDYLQTRIFELAVHSLDIARATGVAAHLPADVLAAATTLAAGIGVALGDGETVLLALTGRAGLPESFSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PR84</accession>
    <name>A0A132PR84_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_08825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846633.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13545"/>
    <dbReference type="EnsemblBacteria" id="KWX24858">
        <property type="protein sequence ID" value="KWX24858"/>
        <property type="gene ID" value="AFM11_08825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5613"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026460">
        <property type="entry name" value="Aldehyde_dehydrogenase_Rv0768"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04284">
        <property type="entry name" value="aldehy_Rv0768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="23"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="489" mass="51435" checksum="AB53391BDCF39D35" modified="2016-06-08" version="1">MPVLADRQSQLLIDGKLVAGGGGVFETVNPATEEVLGVAADANVEDMGNAIEAARRAFDDTDWSTNTELRVRCLRQLRDALRENIEELRELTIAEVGAPRMLTAGAQLEGPIDDLAFSADTAEKYEWRTDLGHATPQGIPTNRVVAREAVGVVGAITPWNFPHQINLAKVGPALAAGNTLILKPAPDTPWAAAAVGQIIAEQTDFPPGVVNIVTSSDHSVGALLSKDPRVDMVSFTGSTATGRAVMTDAALTIKKVFLELGGKSAFLVLDDADLAGACSMAAFTVAMHAGQGCAITTRLVVPRARYDEAVEAAAATLGSIKPGDPNSKRTVCGPLISARQRDRVQSYLDLAIDEGGRFACGGGRPADLDTGFYIEPTVIAGLDNNARVSREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVFSGDDERAQAVAARMRVGTVNVNGGIWYSADAPFGGYKQSGVGREMGLAGFEEYTEIKTIATLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRH5</accession>
    <name>A0A132PRH5_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_09095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13275"/>
    <dbReference type="EnsemblBacteria" id="KWX24797">
        <property type="protein sequence ID" value="KWX24797"/>
        <property type="gene ID" value="AFM11_09095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5668"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX24797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="190" mass="20374" checksum="A1A693DDCB1E158C" modified="2016-06-08" version="1">MSGMLADKARGLATCLMHEQPDRLSHLTGVAARCEALSAAVPPAAVDALVAAGWLHDIGYLPVLGRTGFHPLDGALYLREHGWRDDICALVAHHSGSRFVARVRGLDESLGVFEFVEDESSDVLTVADNTALQDGSFITVSERLREKLARHGPNSPGALANPARDDYIRAASARVRSRLAGHGRSDPYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PRJ2</accession>
    <name>A0A132PRJ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_08275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000004">
        <property type="protein sequence ID" value="KWX24662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067846378.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_00165"/>
    <dbReference type="EnsemblBacteria" id="KWX24662">
        <property type="protein sequence ID" value="KWX24662"/>
        <property type="gene ID" value="AFM11_08275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5506"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="PTHR30618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX24662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="517" mass="55198" checksum="E9E45F3DE8764BD8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PS87</accession>
    <name>A0A132PS87_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisC</name>
        <name evidence="5" type="ORF">AFM11_06865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845474.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_28785"/>
    <dbReference type="EnsemblBacteria" id="KWX25134">
        <property type="protein sequence ID" value="KWX25134"/>
        <property type="gene ID" value="AFM11_06865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4572"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="33"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX25134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="377" mass="40179" checksum="4F747816665BBB22" modified="2016-06-08" version="1">MTGSKDVTLADLPLRDNLRGKSPYGAPQLQVPVRLNTNENPHPPTQALVDDVAASVREAAAELHRYPDRDAVALRTDLAAYLTAATGTHLTVDNLWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIISDGTQTEWLQAARSDDFGLDVDVAIAAIKDRRPDVVFVTSPNNPSGQSIPLDDLRRVLDAMAGGILIVDEAYGEFSSQPSAVALLDEYPAKLVVSRTMSKAFAFAGGRLGYLAAAPAVIDALLLVRLPYHLSVLTQAAARAALRHADETLGSVAKLAAERDRVSAELARLGFRVIPSDANFVLFGEFTDAPATWQRYLDDGVLIRDVGIPGYLRVTIGLAEENDAFLATSAEVAKTELNSPVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSA6</accession>
    <name>A0A132PSA6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_07260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX25203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845694.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_17455"/>
    <dbReference type="EnsemblBacteria" id="KWX25203">
        <property type="protein sequence ID" value="KWX25203"/>
        <property type="gene ID" value="AFM11_07260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4652"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="81"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="325" mass="34845" checksum="9BEF5FC19521CA89" modified="2016-06-08" version="1">MRLKNRFTEKFRILHPVVLAPMDYVADWRLANAVSQAGGLGILGGGYGDEIWLKEQFDHVSGAEIGVGFITWSMERQPGLLDMVIEQRPAAVFLSFSDPAPHAPAIKAARIPLMCQVHDIEQVRHAIEVGADVIVAQGGEAGGHGTAARSTFTLIPEVADLLARESPEVMLLAAGGIGDGRGLAAALALGADGAVVGTRFWAAAEAAIPQAAQARALGATGDETIRQNAFDIVRDKPWPAPYTGRVLRNDFLRRWHGDEPGLRDDLARRREEFRAAVESRNYDIANVIVGEAIGQITAVESAESIIDHMVTAAADILGRSVPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSB8</accession>
    <name>A0A132PSB8_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_05635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="LGTW01000003">
        <property type="protein sequence ID" value="KWX24922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067845050.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_13010"/>
    <dbReference type="EnsemblBacteria" id="KWX24922">
        <property type="protein sequence ID" value="KWX24922"/>
        <property type="gene ID" value="AFM11_05635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4317"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="170"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX24922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="295" mass="30906" checksum="D2B7507E42D3EA78" modified="2016-06-08" version="1">MNSPIAVIGPGAIGSTVAAFLHAAGRPVLLCGRTPRDRVEVRPDGRDPIVIPGPVHTDPAGVAGPVDVVFLAVKDTQNEQAGAWLAQLCGEHTVVCALQNGVEQVERVGRFCPGSQVVPAAVWVSSETQPDGWIWVRTATRLVLPDTASAAVIAQTLRGTDITVELDSDFSTAAWHKLLVNAVVGFMVLTGRRAGMFRRDDVAALARRYLDECLAVARADGAALGDGVPDEILTMLSSGPADVTTSMLTDREAGRPLEWDIRNGVIARKAAVYGLPTPVSDVVVPLLAAASDGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSG1</accession>
    <name>A0A132PSG1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-chlorohydroxyquinol-1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFM11_03090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843842.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25291">
        <property type="protein sequence ID" value="KWX25291"/>
        <property type="gene ID" value="AFM11_03090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2488"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="7">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KWX25291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="293" mass="32161" checksum="683C2F2C6237E4DC" modified="2016-06-08" version="1">MAEDLNADRLTEAVADSFDDTADPRLRQVLQSLTRHLHAFINEVELTYEEWEAGVDFLTRTGKTCTETRQEFILLSDVLGASMLVETLNDVHTPEATASTVLGPFHMIDSPRRGLGEHISPQSAGQLCVVHGHVRDSRGAAIAAALVDVWQANADGFYDVQQPGVQDEGNGRALLTTDESGRFYFQSVVPSYYPIPTDGPVGELLSATGRHEFRPAHIHFIVTAPGYRELTTHIFVNDSKYMDSDAVFAVKESLVRDFVARPAGTPNPCGISEGFVEAQIDLVLHYDGMESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSW9</accession>
    <name>A0A132PSW9_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="8">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">metG</name>
        <name evidence="12" type="ORF">AFM11_04040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="8"/>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844337.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_21115"/>
    <dbReference type="EnsemblBacteria" id="KWX25439">
        <property type="protein sequence ID" value="KWX25439"/>
        <property type="gene ID" value="AFM11_04040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2686"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="10">
        <location>
            <begin position="6"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="11">
        <location>
            <begin position="377"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="302"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KWX25439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="516" mass="57850" checksum="44B14228EF512A29" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PSZ7</accession>
    <name>A0A132PSZ7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_04210</name>
        <name evidence="4" type="ORF">AWC31_20945</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844427.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20945"/>
    <dbReference type="EnsemblBacteria" id="KWX25466">
        <property type="protein sequence ID" value="KWX25466"/>
        <property type="gene ID" value="AFM11_04210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16507">
        <property type="protein sequence ID" value="ORX16507"/>
        <property type="gene ID" value="AWC31_20945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2719"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX16507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="220" mass="23251" checksum="8F213991E7E8CD9D" modified="2016-06-08" version="1">MPDPKRRSPASRPGGPGKSGKSNRPRPAQARRRVTDNRPAQIEQAPDEAVTKAIAVQAQQQAELQSEQRFGSAARRAAILAAVVCVLTLTIAGPVRTYFAQRTEMKQLKASEEQLRAQIAELEQQKVKLADPVYIAAQARERLGFVMPGDTPYQVQLPPTAAVPAEPGVPGAPGSTVPAGQPWYTSLWHTIADQPHGVTSAVPPAPPPAGPPPPTPAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT65</accession>
    <name>A0A132PT65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844574.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25531">
        <property type="protein sequence ID" value="KWX25531"/>
        <property type="gene ID" value="AFM11_04630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2805"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453571" evidence="1">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="104" mass="11011" checksum="9B28B1C37E3F3AF5" modified="2016-06-08" version="1">MRVSIVMLAASGAAVGTILAPAGHASAESPIVTIGQLEAQGFSVNIDRVGSAPLDQCIVTSVRNPQTQTKLIRVERIGKNGKRDFDLIPVVVRRTITVSLDCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PT90</accession>
    <name>A0A132PT90_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_04795</name>
        <name evidence="7" type="ORF">AWC31_20350</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000010">
        <property type="protein sequence ID" value="ORX16408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844629.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20350"/>
    <dbReference type="EnsemblBacteria" id="KWX25559">
        <property type="protein sequence ID" value="KWX25559"/>
        <property type="gene ID" value="AFM11_04795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX16408">
        <property type="protein sequence ID" value="ORX16408"/>
        <property type="gene ID" value="AWC31_20350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2840"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX25559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX16408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="386" mass="40656" checksum="D240BDB802D16E3E" modified="2016-06-08" version="1">MSEQRKWHGLATKAIHAGYRPDPGTGAVNTPIYASSTFAQDGVGGLRGGFEYARTGNPTRQALEAALAAVEEAAYGRAFASGMAATDCALRAVLRPGDHVVIPNDAYGGTFRLIDKVFSQWGITHTPVPLSDLDAVRSALTSRTRMIWVETPTNPLLTIADISGIVQIASTSGVKVLVDNTFASPALQQPLLHGADIVLHSTTKYLGGHSDVVGGALLTNDEELDAAFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMRQHSENAALIAEFLEGHPAVETVLYPGLASHPNHNVAARQMTGFGGMVSVRLKGGQRAARELCSRTELFILAESLGGVESLIEYPGAMTHASTAGSQLEVPDDLVRLSVGIEHAADLLADIEQALSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTE7</accession>
    <name>A0A132PTE7_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_04995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844702.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25593">
        <property type="protein sequence ID" value="KWX25593"/>
        <property type="gene ID" value="AFM11_04995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2880"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="228"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="394" mass="42456" checksum="1D2360501BFF58E3" modified="2016-06-08" version="1">MPLTQPWPPTAATTLPADHQRAALVGRVFRADVGGPSVVTVRDGELVDITATFPTMRDLAEHPDPADAVGCATGERIGPLADALATTPPEYASPQQNRLLSPIDLQCVKAAGVTFVASMLERMIEERSRGDAEKAEHFRRHIVELTGAHLADIAPGSAAAARIKELLVAEDAWSQYLEVGIGPDAEIFTKTAPMSSVGTAVDIGVHPRSTWNNPEPEVVLLVSSTRRIVGATLGNDVNLRDFEGRSALLLTKAKDNNASCAIGPFVRLFDDGFDLDTVRNCDVELRVHGRDGFVLDGRSSMKQISRDPEELVAQLTATHQYPDGAVLFLGTMFAPTDDRDAPGQGFTHHVDDLVTISSPTLGTLVNRVRTSDQVAPWTFGTADLFRNLATRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTF0</accession>
    <name>A0A132PTF0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_05145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067844753.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_20095"/>
    <dbReference type="EnsemblBacteria" id="KWX25618">
        <property type="protein sequence ID" value="KWX25618"/>
        <property type="gene ID" value="AFM11_05145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2910"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="186" mass="20152" checksum="BA4B3C26726C09C5" modified="2016-06-08" version="1">MGTAPYGVRLLVGAAVTALEETRKLPQTILTYPMTVASQAANIVMHVQQNLAELVIKGDETLEQLFPPKDEQAEWATFDEDLEDDEPAAGNTPDGERRTEGRFALYSSGEPESANSEPETPAEPAEAPAIVEELGYESLTLAQLRARLSSLRVADLEALLAFEEAGRARAPFVTLLANRITRATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PTT5</accession>
    <name>A0A132PTT5_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_00125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842069.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33235"/>
    <dbReference type="EnsemblBacteria" id="KWX25746">
        <property type="protein sequence ID" value="KWX25746"/>
        <property type="gene ID" value="AFM11_00125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.26"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX25746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="501" mass="52689" checksum="C3878611C2CDA7B9" modified="2016-06-08" version="1">MSAPATSLTGQMLRRRPVIGAPVAHGASDHLKRSIGTFQLTLFGVGATVGTGIFIVLQQAVPEAGPAVLVSFVLAGVAAGLSAICYAEMASAVPVSGSTYSYAYTTMGEFVAMGVAACLLLEYGVSMSATAIGWGGYLNQLLDNLFGFRLPHALTAAPWGEEPGIMNLPATILIFMCALLLIRGASESALVNTVMVILKLAVLGLFIAVAFTAFTTDHFAGFWDKGFVGITAAASTIFFTFIGLDAVSTAGDEVKNPQKTMPRAIIGALIVVTSVYVLVAFAGLGTQSADEFGSEEQAEAGLSVMLTNILHGQTWASTILAAGAVISIFSVTLVVMYGQTRILFAMGRDGLLPSMFAKVNPRSMTPVNNTIIVAVVTGTLAGFVPLDYLWDLVSIGTLIAFVVVSVGVIILRVREPDLPRSFKVPGYPVTPILSVAACLFVLYGLPAITWLWFGLWVSAVLLFYLVWSRHHSALNDGGDGYIPGAAAGEDDVMTTRPEDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PU53</accession>
    <name>A0A132PU53_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fluoroquinolone transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_00630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067842341.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_33740"/>
    <dbReference type="EnsemblBacteria" id="KWX25835">
        <property type="protein sequence ID" value="KWX25835"/>
        <property type="gene ID" value="AFM11_00630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.129"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX25835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="237" mass="25952" checksum="489540460923731E" modified="2016-06-08" version="1">MTRLLSAVRLEVMVQYRQKFLHAGFFSGLMWLAVLLPMPHSLRPVAEPYALIGDIAIIGFFFIGGSVFFEKQERTLGAVISTPLRFWEYLTAKLAVLLAISLIVAIVVVIISSGTAYRPVPMVLGVVLGTLLMLMVGFISSLPFTSVTDWFLFSVIPLAAMLVPPILHHSGLWPNPALYVVPTQGPMLLLGAAFGQVTLSAWQVVYAVGYPVLCLAVLWRAAHALFGHYVIERSGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUH2</accession>
    <name>A0A132PUH2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFM11_01630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX25991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25991">
        <property type="protein sequence ID" value="KWX25991"/>
        <property type="gene ID" value="AFM11_01630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.336"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453603" evidence="2">
        <location>
            <begin position="28"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KWX25991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="317" mass="33141" checksum="1B2E777CE7224BA6" modified="2016-06-08" version="1">MRAPLRLGLYVAALVAIFVAGFVGARAFIPADESASWKRQTEATQMDHGAHHGGHNGSASSADVPGLSIERSGYQIRDVAAPDVVGEDGTLSFRLTGPGGVALTEYDTAHDKDLHLIVVRSDGAEFRHVHPHYDGDGRWSMPWRWNAAGSYRIFADAVPSDLGSNVTLSSTTSVAGNLVPRPLPPESAVATVGDITVTLDGSLGVGATSTLTFTVTRAGQPVQTLEPYLGAYGHLVALRTGDLGYLHVHPMGEPGDGITQPGPDIEFMAAAPTDGTYLLYLDFKVDGQVHTAEFTVTAAPGIATAGSPEPEHSGAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUI4</accession>
    <name>A0A132PUI4_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_04420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000002">
        <property type="protein sequence ID" value="KWX25702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX25702">
        <property type="protein sequence ID" value="KWX25702"/>
        <property type="gene ID" value="AFM11_04420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.2760"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX25702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="325" mass="35454" checksum="4FFFDC4DCC592B05" modified="2016-06-08" version="1">MVSSTGCGPFRQENPMETSLPSAKFGLRVTDGELRFWTGAPCPGTTGVTLEFSNPQTDDATLELSTPSYDEGLMPGVELEHLTLDGPYPGFSVKQPLPQGFDWHTAQRLDLLVYGPPNSQGIGIDFAPIATEISEHSAEHPEDTYYFPDIGWLSPAEVAAKDGKEFMTVCTPDPARDEAVAATVGVRVTDGTLRFWTGTPCPFDSGVVLTFQPGQVETTLKNTELDPDFEHLNLGEPAPQFTVTRPLPNDFDWRTAKSVLFRLVKTDTATNRANQLVWSKTTELATPIAESAQHPADTYYFEGHGWLSPAEVAAKDGSIQTICDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PUS2</accession>
    <name>A0A132PUS2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843087.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34905"/>
    <dbReference type="EnsemblBacteria" id="KWX26063">
        <property type="protein sequence ID" value="KWX26063"/>
        <property type="gene ID" value="AFM11_02125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.435"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="489" mass="51488" checksum="4651B7395EC56A52" modified="2016-06-08" version="1">MPAARGAERNRIPVDDSLTFGTATDLAAALRRRDVSAREVLAAHLGQIDRRNAAVNAVVSLDVDGAERAAAEADRRCAAGEPLGRLHGLPIAFKDTHATAGMRTTFGSPLHSNWIPQTDDEIVRRIQDAGAVRLGKTNVPEFAAGSHSFNPIFGTTRNPYAIDRSAGGSSGGAAAALASGMQPIADGSDMGGSLRNPASFCNVVGLRPTPGRVPDPGAAWAYPNLATAGPMARTVADVALLLSVIAGPHRDDPTSLSDDPAAFATLNPADLKGLRVAWAPTLGDRIPVDAEVLAPLESAAAVFADLGAHVEPACPDLDGADATFRTLRAVEFDAMWGDQLDATPEAFKADLAWNIREGRARTARDIGRALAELTRLQRAACAFFDTYDVLLAPVSQVAPFDADQLWPTEVAGMPQHTYLDWMASCYLITTLGVPAISVPAGFTSDGLPVGLQIVTRARTEQMLLAVAAAFEEATGHGRRRPVLTLECRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV04</accession>
    <name>A0A132PV04_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_02640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843364.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_35415"/>
    <dbReference type="EnsemblBacteria" id="KWX26150">
        <property type="protein sequence ID" value="KWX26150"/>
        <property type="gene ID" value="AFM11_02640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.541"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="144" mass="15385" checksum="2B8E6594CBC4DFD2" modified="2016-06-08" version="1">MPTISVAKRATPIPGDGNDRAQFSSRWLWPTTAMVSATGELDAANAAEFTDYGLEHVRTDGKLVLDLSAVTFFGAACFASLHTVNVRCVGENVDWVLIPSKAVSRVLRICDPDAALPTSSDATAALSSLRTEPRPLQLVAKEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PV99</accession>
    <name>A0A132PV99_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_01455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000001">
        <property type="protein sequence ID" value="KWX26243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067843622.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_34425"/>
    <dbReference type="EnsemblBacteria" id="KWX26243">
        <property type="protein sequence ID" value="KWX26243"/>
        <property type="gene ID" value="AFM11_01455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.298"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="150"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX26243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="296" mass="31303" checksum="07B8E47D6C2949F8" modified="2016-06-08" version="1">MKLVVGYLATPGGADALALAVRFARTLDAEVEICIVLPPDTRLPGLVPKGGYEDVLADQAKGWLNEALAKVPDDVVAHGHLSFDESFTDGLIREAVRLEALAIVVGGSGGGLVGSYSLGSVVNELLHSSPLPVAVAPRGTRDSKVERVREVTCAIGQRKGSDLLLDTAVRASRAAGTPLRLVSLVALDPTFGSLRSDDDAVREHALAHAQETLETAKSELPEGFPVTSTIVNGPTVEAAVNKLEWHDGDVIMVGSSRLSAPRRIFLGSTAAKMLRVLDVPMVVVPRDELKDGEERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PAZ2</accession>
    <name>A0A132PAZ2_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_35555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000045">
        <property type="protein sequence ID" value="KWX19501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859857.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_02695"/>
    <dbReference type="EnsemblBacteria" id="KWX19501">
        <property type="protein sequence ID" value="KWX19501"/>
        <property type="gene ID" value="AFM11_35555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5847"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453162" evidence="3">
        <location>
            <begin position="22"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="85"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX19501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="534" mass="58854" checksum="B73279B50D588784" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB37</accession>
    <name>A0A132PB37_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_35220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19543">
        <property type="protein sequence ID" value="KWX19543"/>
        <property type="gene ID" value="AFM11_35220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5774"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="91" mass="10017" checksum="13F4C4EC39D9FC72" modified="2016-06-08" version="1">MTEDDGGTGGVDRSSPAPLRQRPAPGALDDRDEPSPEDDWSIDDLEDWPFADPSVDVARLWESLIESEADIAAGRTFGEDEIRTDYGLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB62</accession>
    <name>A0A132PB62_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19550">
        <property type="protein sequence ID" value="KWX19550"/>
        <property type="gene ID" value="AFM11_35260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="65" mass="7599" checksum="B009AF64BDC1671B" modified="2016-06-08" version="1">MAFYVRVQSKRVDQYDDEHDLIVHDSGIIEVKHDGQQVMLYSPAHWTEVKPGIYEKTPARVTTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PB65</accession>
    <name>A0A132PB65_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_35305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000042">
        <property type="protein sequence ID" value="KWX19558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859782.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19558">
        <property type="protein sequence ID" value="KWX19558"/>
        <property type="gene ID" value="AFM11_35305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5791"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX19558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="134" mass="14485" checksum="49B5900BC0B678AB" modified="2016-06-08" version="1">MAIDEVQQSKTKPTQHPAFRRFAILVLALAAIAGLTGLVQPGLGQPAVAQAFTFQGPDRVGFGRAVVLFSREETRAIGQSKLKLPGTNPAFIAFNIASAGIAGIARNYYDRGLCSAYAWSVRPWDNQGFMSRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PBF3</accession>
    <name>A0A132PBF3_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Bacterioferritin</fullName>
            <ecNumber evidence="5">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFM11_34755</name>
        <name evidence="10" type="ORF">AWC31_10900</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the bacterioferritin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="5"/>
    <dbReference type="EMBL" id="LGTW01000039">
        <property type="protein sequence ID" value="KWX19646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000035">
        <property type="protein sequence ID" value="ORX09074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067859523.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_10900"/>
    <dbReference type="EnsemblBacteria" id="KWX19646">
        <property type="protein sequence ID" value="KWX19646"/>
        <property type="gene ID" value="AFM11_34755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX09074">
        <property type="protein sequence ID" value="ORX09074"/>
        <property type="gene ID" value="AWC31_10900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5299"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00907">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00754">
        <property type="entry name" value="bfr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00549">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0409">Iron storage</keyword>
    <keyword evidence="5 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="8">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002560-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KWX19646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX09074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="159" mass="18359" checksum="EC49E83A063C9F89" modified="2016-06-08" version="1">MQGDPEVLKLLNEQLTSELTAINQYFLHSKMQDNWGFTELAEHTRSESFEEMRHAEAITDRILLLDGLPNYQRLFSLRVGQTLREQFEADLAIEYEVVARLKPGILMCREKQDAVSANLFEGILKDEEGHIDYLETQLELMDKLGEQLYAAQCVSRPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PC47</accession>
    <name>A0A132PC47_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_33510</name>
        <name evidence="3" type="ORF">AWC31_02240</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000034">
        <property type="protein sequence ID" value="KWX19899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000023">
        <property type="protein sequence ID" value="ORX13361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858739.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19899">
        <property type="protein sequence ID" value="KWX19899"/>
        <property type="gene ID" value="AFM11_33510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX13361">
        <property type="protein sequence ID" value="ORX13361"/>
        <property type="gene ID" value="AWC31_02240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.5035"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007453135" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX19899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX13361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="73" mass="7807" checksum="E3E9B840A596727E" modified="2016-06-08" version="1">MNFVKKIATTAATVGALGFAAVGIGAGQANADEPWWWEPVPPPGHFVPSPGHISHLPFVPPPGHWDKPGKWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PCV1</accession>
    <name>A0A132PCV1_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31980</name>
        <name evidence="2" type="ORF">AWC31_31915</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CDC_01</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2016-01" db="EMBL/GenBank/DDBJ databases">
            <title>The new phylogeny of the genus Mycobacterium.</title>
            <authorList>
                <person name="Tarcisio F."/>
                <person name="Conor M."/>
                <person name="Antonella G."/>
                <person name="Elisabetta G."/>
                <person name="Giulia F.S."/>
                <person name="Sara T."/>
                <person name="Anna F."/>
                <person name="Clotilde B."/>
                <person name="Roberto B."/>
                <person name="Veronica D.S."/>
                <person name="Fabio R."/>
                <person name="Monica P."/>
                <person name="Olivier J."/>
                <person name="Enrico T."/>
                <person name="Nicola S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 700010</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LQQA01000029">
        <property type="protein sequence ID" value="ORX12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857827.1">
        <property type="nucleotide sequence ID" value="NZ_LQQA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_31915"/>
    <dbReference type="EnsemblBacteria" id="KWX20163">
        <property type="protein sequence ID" value="KWX20163"/>
        <property type="gene ID" value="AFM11_31980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ORX12567">
        <property type="protein sequence ID" value="ORX12567"/>
        <property type="gene ID" value="AWC31_31915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4722"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193964">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193964"/>
        </source>
    </evidence>
    <sequence length="229" mass="24017" checksum="98F1CB2A6157E3AC" modified="2016-06-08" version="1">MGVVYLVRHGQARAQAYGAAARSRADGGLTDLGRAQATSTGKALAARVDSITAAISGDLARQEETLECVLRAAAHEGTPVSNPHWNEYDMDAILGGGQLATTGAGRELQSSVDAALHDWTTPQGLPYSVAESYEDYQRRCALALQSVSELAGPGQTVVAVSSSGTIAQILAQIWDLPASSWIRLSRTMINASITKLIVGSTGVSVVSVNEHAHLDIPDATGARAMMTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD09</accession>
    <name>A0A132PD09_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-3-methyladenine glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFM11_32675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CDC_01</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000031">
        <property type="protein sequence ID" value="KWX20107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858194.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_19810"/>
    <dbReference type="EnsemblBacteria" id="KWX20107">
        <property type="protein sequence ID" value="KWX20107"/>
        <property type="gene ID" value="AFM11_32675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4863"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="87"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX20107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="496" mass="54067" checksum="354BE28B80D6B938" modified="2016-06-08" version="1">MHEDFDRCYRAVQSKDARFDGWFVTAVLTTGIYCRPSCPVRPPFAKNMRFYPTAAAAQAAGFRACKRCRPDASPGSPEWNMRGDVVARCMRLIADGTVDREGVTGLAARVGYTTRQLQRILQAELGANPLALARAQRSQTARVLIETTELPFSDVAFAAGFASIRQFNDTIRAVCDMPPSELRRRARTRIAMDDTASPGMLSLRLPVRSPFAYEGLFGHLAASAVPGVEEVRDGIYRRTLRLPHGNGIVGLEPQPDHVRCQLVLDDFRDLSAAIARCRRLLDLDADPEAVVDALGADTDLSAVVAKAPGQRIPRTVDEAELALRVVIGQQVSIKAARTHAGRLAAAYGSAVRDEQGGLTHVFPSVADLAEVDPSHLAMPESRKRTVRAMVSALAEDALVLDPGCDWHRAREQLLALPGVGPWTAEVIALRGLGDPDAFPATDLGVKLAAEQLGLPTEPGALIAHSTRWRPWRAYATQHLWTTLDHAVNHWPPNANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD20</accession>
    <name>A0A132PD20_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_31330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857449.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25485"/>
    <dbReference type="EnsemblBacteria" id="KWX20233">
        <property type="protein sequence ID" value="KWX20233"/>
        <property type="gene ID" value="AFM11_31330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4172"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KWX20233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="205" mass="22787" checksum="81BA7D2C1440DACB" modified="2016-06-08" version="1">MARRRGWDGRPPSSDEEATARIVDAAVKLISETGSDVSIADVAASLGVIRQTVYRYFPTADSLMHAAALASVDGFFDRLAEAVRGITDPAEAMTEGVVFTLEEVTRTPHLGILLSEPYLHSHSGNLASDEAQTFGMRMLTRFDVDWDKYGYDEPAQRELVEFTLRVMMSFFVAPNESTRSRDELRRFIRRWLGGAILAQPVDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PD24</accession>
    <name>A0A132PD24_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_32210</name>
        <name evidence="6" type="ORF">AFM11_35630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000046">
        <property type="protein sequence ID" value="KWX19481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LGTW01000030">
        <property type="protein sequence ID" value="KWX20216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX19481">
        <property type="protein sequence ID" value="KWX19481"/>
        <property type="gene ID" value="AFM11_35630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KWX20216">
        <property type="protein sequence ID" value="KWX20216"/>
        <property type="gene ID" value="AFM11_32210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KWX19481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="84" mass="8500" checksum="85126B4EB8126FC1" modified="2016-06-08" version="1" fragment="single">MNSPVLLGFLTTMALIAAIGAQNAFVLRQGIRREHVVPVIAVCTISDLILIAAGIAGVGALITAHPDAVTVAKFGGAAFLIGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDB0</accession>
    <name>A0A132PDB0_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFM11_31635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000029">
        <property type="protein sequence ID" value="KWX20284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857611.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26250"/>
    <dbReference type="EnsemblBacteria" id="KWX20284">
        <property type="protein sequence ID" value="KWX20284"/>
        <property type="gene ID" value="AFM11_31635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4231"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KWX20284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="246" mass="25503" checksum="5B7C8CFC23E27B12" modified="2016-06-08" version="1">MSLLTGQTAVVTGGAQGLGLAIAKRFIAEGARVVLGDLNLDATEAAAQELGGAEVATAVRCDVTSASDVQALVDAAVQSFGGLDIMVNNAGITRDATLRKMTEEQFDQVIAVHLKGTWNGTKSAAAIMRENKRGAIVNMSSISGKVGLIGQTNYSAAKAGIVGMTKASAKELAHLGVRVNAIQPGLIRSAMTEAMPQRIWDQKLAEVPMGRAGEPDEVAKVALFLASDLSSYMTGTVLEVTGGRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDE6</accession>
    <name>A0A132PDE6_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_32810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000032">
        <property type="protein sequence ID" value="KWX19992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067858309.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_32185"/>
    <dbReference type="EnsemblBacteria" id="KWX19992">
        <property type="protein sequence ID" value="KWX19992"/>
        <property type="gene ID" value="AFM11_32810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4891"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="3">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="124"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX19992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="376" mass="40861" checksum="5AA475B3D9CC4706" modified="2016-06-08" version="1">MDFSTVELSPDDQAFQRELRDFLAATVTDEVLARDRETGENFDEGVHLALGSAGYLAADYRSAADGGFSAVRRRIWELEIGRAHTPWFHWGTTAMVAHTVEQFASAELVDEVLPGVLAGRLRLCLGYTEPEGGSDVATCKTRAVRDGEDWTINGSKMFTSNAHNAQYVFLVTNTDPGAPKHKSLTMFLVPLDAPGVEIQGIRTVDGDRTNITYYSDVRVADRYRVGEVNGGWAVLRGALDVEHGTFERDSAGLQKIATMTEHITLMAEAVDRVAAAVPDDEAARYRLGRGIARMEAAMSTPQMYGRVAIAQTMRDVSPDLMDILGPAGSLTDGVEYIFRLAGPTGIYGGTLEVFRNMIAQHGLGLGKPNYSPPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDE9</accession>
    <name>A0A132PDE9_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFM11_30685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CDC_01</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000028">
        <property type="protein sequence ID" value="KWX20324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067857086.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_26405"/>
    <dbReference type="EnsemblBacteria" id="KWX20324">
        <property type="protein sequence ID" value="KWX20324"/>
        <property type="gene ID" value="AFM11_30685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.4038"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="249"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KWX20324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="382" mass="40406" checksum="3FA6CEC69A845EE4" modified="2016-06-08" version="1">MTNDVAIIGVGIHPFGRFEGKSAMQMGVDAIFAAVADAGVEWKDIGAATGGSWTVANPDAIVGMVGLSGIPFTNVFNACATAASATKACADGIRLGDYDIGIAVGLDKHPRGAFTEDPALVGMPSWYAENGQYLTTQFFGMKANRYLHDHNISQRTLARVAAKNFRNGALNPNAFRRKPISEDDILNSTMLNYPLTQYMFCAPDEGAAAVIMCRADIAHRYTDKPVYLKAVEVRTRRYGAYEVNTTCAPVEEDVAPTVYAARAAFEKSGVAPEDVDIVQLQDTDAGAEIIHMAECGFCADGDQEKLLADGATEIGGSLPVNTDGGLIANGEPIGASGLRQIHELVRQLRGEAGDRQVPGEPKVGFAQLYGAPGTAGATVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PDY7</accession>
    <name>A0A132PDY7_9MYCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0182 protein AFM11_29505</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFM11_29505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CDC_01</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0182 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856414.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_24845"/>
    <dbReference type="EnsemblBacteria" id="KWX20545">
        <property type="protein sequence ID" value="KWX20545"/>
        <property type="gene ID" value="AFM11_29505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3792"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="903"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="937"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KWX20545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="1005" mass="109222" checksum="6A148075F9068E0F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE79</accession>
    <name>A0A132PE79_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFM11_29835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI Taxonomy" id="59750"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycolicibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome sequence of Mycobacterium wolinskyi.</title>
            <authorList>
                <person name="de Man T.J."/>
                <person name="Perry K.A."/>
                <person name="Coulliette A.D."/>
                <person name="Jensen B."/>
                <person name="Toney N.C."/>
                <person name="Limbago B.M."/>
                <person name="Noble-Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CDC_01</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGTW01000026">
        <property type="protein sequence ID" value="KWX20646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_067856723.1">
        <property type="nucleotide sequence ID" value="NZ_LGTW01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="59750.AWC31_25175"/>
    <dbReference type="EnsemblBacteria" id="KWX20646">
        <property type="protein sequence ID" value="KWX20646"/>
        <property type="gene ID" value="AFM11_29835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|59750.3.peg.3859"/>
    <dbReference type="Proteomes" id="UP000070612">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019919">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03617">
        <property type="entry name" value="F420_MSMEG_2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KWX20646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070612"/>
        </source>
    </evidence>
    <sequence length="323" mass="34673" checksum="A2936139F8194ADF" modified="2016-06-08" version="1">MTALFGPMDAIERAQALREAGASGVFTFEGPHDVFAPLTLAATVGGLDLMTNVAIAFPRNPIHLAHQAIDHQLLSGGRFTLGLGTQIRTQIEKRFGADFDRPVARMSELIGALRAIFAAWQTGERLDFRGEFYRHTLMTPTFSPGTNPYGPPPIYVGALGPRLTRATAELADGLLVMPFGSKRFLNEVTMPAVRAGLAAANRDPDAFAVVPEIIVSVGDDHDAARRLLAFYGSTPAYRPVLEVHGWGELQPELNALSKQGRWLEMGSLIDDKVLHTIAACGSPAEIATHIADRVAGVSDRICLYQPGPIAVDSLAQIVDALAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A132PE88</accession>
    <name>A0A132PE88_9MYCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFM11_29735</name>
        <name evidence="6" type="ORF">AWC31_25075</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mycolicibacterium wolinskyi</name>
        <dbReference type="NCBI T